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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CANX-RUFY1 (FusionGDB2 ID:HG821TG80230)

Fusion Gene Summary for CANX-RUFY1

check button Fusion gene summary
Fusion gene informationFusion gene name: CANX-RUFY1
Fusion gene ID: hg821tg80230
HgeneTgene
Gene symbol

CANX

RUFY1

Gene ID

821

80230

Gene namecalnexinRUN and FYVE domain containing 1
SynonymsCNX|IP90|P90RABIP4|ZFYVE12
Cytomap('CANX')('RUFY1')

5q35.3

5q35.3

Type of geneprotein-codingprotein-coding
Descriptioncalnexinepididymis secretory sperm binding proteinmajor histocompatibility complex class I antigen-binding protein p88RUN and FYVE domain-containing protein 1FYVE-finger protein EIP1la-binding protein 1rab4-interacting proteinzinc finger FYVE domain-containing protein 12
Modification date2020031320200327
UniProtAcc

P27824

.
Ensembl transtripts involved in fusion geneENST00000247461, ENST00000415618, 
ENST00000452673, ENST00000503126, 
ENST00000504734, ENST00000512607, 
Fusion gene scores* DoF score15 X 16 X 11=26407 X 10 X 6=420
# samples 2110
** MAII scorelog2(21/2640*10)=-3.65207669657969
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CANX [Title/Abstract] AND RUFY1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCANX(179155785)-RUFY1(179023563), # samples:2
Anticipated loss of major functional domain due to fusion event.CANX-RUFY1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CANX-RUFY1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CANX-RUFY1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CANX-RUFY1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CANX-RUFY1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CANX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RUFY1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-2F-A9KO-01ACANXchr5

179136060

+RUFY1chr5

179020479

+
ChimerDB4BRCATCGA-E2-A15E-01ACANXchr5

179155785

+RUFY1chr5

179023563

+
ChimerDB4BRCATCGA-E2-A15E-06ACANXchr5

179155785

+RUFY1chr5

179023563

+
ChimerDB4TGCTTCGA-2G-AAKMCANXchr5

179137066

+RUFY1chr5

179036377

+


Top

Fusion Gene ORF analysis for CANX-RUFY1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000247461ENST00000319449CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3CDSENST00000415618ENST00000319449CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3CDSENST00000452673ENST00000319449CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3CDSENST00000503126ENST00000319449CANXchr5

179136060

+RUFY1chr5

179020479

+
3UTR-3CDSENST00000503126ENST00000319449CANXchr5

179137066

+RUFY1chr5

179036377

+
3UTR-3CDSENST00000504734ENST00000319449CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3UTRENST00000247461ENST00000377001CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3UTRENST00000247461ENST00000393438CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3UTRENST00000247461ENST00000437570CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3UTRENST00000415618ENST00000377001CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3UTRENST00000415618ENST00000393438CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3UTRENST00000415618ENST00000437570CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3UTRENST00000452673ENST00000377001CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3UTRENST00000452673ENST00000393438CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3UTRENST00000452673ENST00000437570CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3UTRENST00000503126ENST00000377001CANXchr5

179136060

+RUFY1chr5

179020479

+
3UTR-3UTRENST00000503126ENST00000377001CANXchr5

179137066

+RUFY1chr5

179036377

+
3UTR-3UTRENST00000503126ENST00000393438CANXchr5

179136060

+RUFY1chr5

179020479

+
3UTR-3UTRENST00000503126ENST00000393438CANXchr5

179137066

+RUFY1chr5

179036377

+
3UTR-3UTRENST00000503126ENST00000437570CANXchr5

179136060

+RUFY1chr5

179020479

+
3UTR-3UTRENST00000503126ENST00000437570CANXchr5

179137066

+RUFY1chr5

179036377

+
3UTR-3UTRENST00000503126ENST00000508797CANXchr5

179137066

+RUFY1chr5

179036377

+
3UTR-3UTRENST00000504734ENST00000377001CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3UTRENST00000504734ENST00000393438CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-3UTRENST00000504734ENST00000437570CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-intronENST00000247461ENST00000508797CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-intronENST00000415618ENST00000508797CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-intronENST00000452673ENST00000508797CANXchr5

179155785

+RUFY1chr5

179023563

+
3UTR-intronENST00000503126ENST00000508797CANXchr5

179136060

+RUFY1chr5

179020479

+
3UTR-intronENST00000504734ENST00000508797CANXchr5

179155785

+RUFY1chr5

179023563

+
5CDS-3UTRENST00000247461ENST00000377001CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000247461ENST00000377001CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000247461ENST00000393438CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000247461ENST00000393438CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000247461ENST00000437570CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000247461ENST00000437570CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000247461ENST00000508797CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000415618ENST00000377001CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000415618ENST00000377001CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000415618ENST00000393438CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000415618ENST00000393438CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000415618ENST00000437570CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000415618ENST00000437570CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000415618ENST00000508797CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000452673ENST00000377001CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000452673ENST00000377001CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000452673ENST00000393438CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000452673ENST00000393438CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000452673ENST00000437570CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000452673ENST00000437570CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000452673ENST00000508797CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000504734ENST00000377001CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000504734ENST00000377001CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000504734ENST00000393438CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000504734ENST00000393438CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000504734ENST00000437570CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000504734ENST00000437570CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000504734ENST00000508797CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000512607ENST00000377001CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000512607ENST00000377001CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000512607ENST00000393438CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000512607ENST00000393438CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000512607ENST00000437570CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-3UTRENST00000512607ENST00000437570CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-3UTRENST00000512607ENST00000508797CANXchr5

179137066

+RUFY1chr5

179036377

+
5CDS-intronENST00000247461ENST00000508797CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-intronENST00000415618ENST00000508797CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-intronENST00000452673ENST00000508797CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-intronENST00000504734ENST00000508797CANXchr5

179136060

+RUFY1chr5

179020479

+
5CDS-intronENST00000512607ENST00000508797CANXchr5

179136060

+RUFY1chr5

179020479

+
Frame-shiftENST00000247461ENST00000319449CANXchr5

179137066

+RUFY1chr5

179036377

+
Frame-shiftENST00000415618ENST00000319449CANXchr5

179137066

+RUFY1chr5

179036377

+
Frame-shiftENST00000452673ENST00000319449CANXchr5

179137066

+RUFY1chr5

179036377

+
Frame-shiftENST00000504734ENST00000319449CANXchr5

179137066

+RUFY1chr5

179036377

+
Frame-shiftENST00000512607ENST00000319449CANXchr5

179137066

+RUFY1chr5

179036377

+
In-frameENST00000247461ENST00000319449CANXchr5

179136060

+RUFY1chr5

179020479

+
In-frameENST00000415618ENST00000319449CANXchr5

179136060

+RUFY1chr5

179020479

+
In-frameENST00000452673ENST00000319449CANXchr5

179136060

+RUFY1chr5

179020479

+
In-frameENST00000504734ENST00000319449CANXchr5

179136060

+RUFY1chr5

179020479

+
In-frameENST00000512607ENST00000319449CANXchr5

179136060

+RUFY1chr5

179020479

+
intron-3CDSENST00000503126ENST00000319449CANXchr5

179155785

+RUFY1chr5

179023563

+
intron-3CDSENST00000512607ENST00000319449CANXchr5

179155785

+RUFY1chr5

179023563

+
intron-3UTRENST00000503126ENST00000377001CANXchr5

179155785

+RUFY1chr5

179023563

+
intron-3UTRENST00000503126ENST00000393438CANXchr5

179155785

+RUFY1chr5

179023563

+
intron-3UTRENST00000503126ENST00000437570CANXchr5

179155785

+RUFY1chr5

179023563

+
intron-3UTRENST00000512607ENST00000377001CANXchr5

179155785

+RUFY1chr5

179023563

+
intron-3UTRENST00000512607ENST00000393438CANXchr5

179155785

+RUFY1chr5

179023563

+
intron-3UTRENST00000512607ENST00000437570CANXchr5

179155785

+RUFY1chr5

179023563

+
intron-intronENST00000503126ENST00000508797CANXchr5

179155785

+RUFY1chr5

179023563

+
intron-intronENST00000512607ENST00000508797CANXchr5

179155785

+RUFY1chr5

179023563

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000504734CANXchr5179136060+ENST00000319449RUFY1chr5179020479+2107718371599520
ENST00000415618CANXchr5179136060+ENST00000319449RUFY1chr5179020479+2097708271589520
ENST00000452673CANXchr5179136060+ENST00000319449RUFY1chr5179020479+20646751471556469
ENST00000247461CANXchr5179136060+ENST00000319449RUFY1chr5179020479+21177282001609469
ENST00000512607CANXchr5179136060+ENST00000319449RUFY1chr5179020479+19765872661468400

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000504734ENST00000319449CANXchr5179136060+RUFY1chr5179020479+0.0018210040.99817896
ENST00000415618ENST00000319449CANXchr5179136060+RUFY1chr5179020479+0.0018750710.9981249
ENST00000452673ENST00000319449CANXchr5179136060+RUFY1chr5179020479+0.0032309810.9967691
ENST00000247461ENST00000319449CANXchr5179136060+RUFY1chr5179020479+0.0036015610.99639845
ENST00000512607ENST00000319449CANXchr5179136060+RUFY1chr5179020479+0.0037432810.9962567

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Fusion Genomic Features for CANX-RUFY1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CANXchr5179136060+RUFY1chr5179020478+3.75E-131
CANXchr5179137066+RUFY1chr5179036376+1.11E-081
CANXchr5179136060+RUFY1chr5179020478+3.75E-131
CANXchr5179137066+RUFY1chr5179036376+1.11E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CANX-RUFY1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:179155785/chr5:179023563)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CANX

P27824

.
FUNCTION: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRUFY1chr5:179136060chr5:179020479ENST00000393438918321_374307601.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY1chr5:179136060chr5:179020479ENST00000393438918405_617307601.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY1chr5:179136060chr5:179020479ENST00000437570817321_374307601.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY1chr5:179136060chr5:179020479ENST00000437570817405_617307601.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY1chr5:179136060chr5:179020479ENST00000319449918642_700415709.0Zinc fingerFYVE-type
TgeneRUFY1chr5:179136060chr5:179020479ENST000003770011019642_700463522.0Zinc fingerFYVE-type
TgeneRUFY1chr5:179136060chr5:179020479ENST00000393438918642_700307601.0Zinc fingerFYVE-type
TgeneRUFY1chr5:179136060chr5:179020479ENST00000437570817642_700307601.0Zinc fingerFYVE-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+615276_409176593.0RegionP domain (Extended arm)
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+615278_345176593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+615348_405176593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+615276_409176593.0RegionP domain (Extended arm)
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+615278_345176593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+615348_405176593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+615276_409176593.0RegionP domain (Extended arm)
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+615278_345176593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+615348_405176593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+615278_290176593.0RepeatNote=1-1
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+615295_307176593.0RepeatNote=1-2
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+615314_326176593.0RepeatNote=1-3
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+615333_345176593.0RepeatNote=1-4
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+615348_358176593.0RepeatNote=2-1
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+615367_377176593.0RepeatNote=2-2
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+615381_391176593.0RepeatNote=2-3
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+615395_405176593.0RepeatNote=2-4
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+615278_290176593.0RepeatNote=1-1
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+615295_307176593.0RepeatNote=1-2
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+615314_326176593.0RepeatNote=1-3
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+615333_345176593.0RepeatNote=1-4
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+615348_358176593.0RepeatNote=2-1
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+615367_377176593.0RepeatNote=2-2
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+615381_391176593.0RepeatNote=2-3
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+615395_405176593.0RepeatNote=2-4
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+615278_290176593.0RepeatNote=1-1
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+615295_307176593.0RepeatNote=1-2
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+615314_326176593.0RepeatNote=1-3
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+615333_345176593.0RepeatNote=1-4
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+615348_358176593.0RepeatNote=2-1
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+615367_377176593.0RepeatNote=2-2
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+615381_391176593.0RepeatNote=2-3
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+615395_405176593.0RepeatNote=2-4
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+61521_481176593.0Topological domainLumenal
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+61521_481176593.0Topological domainLumenal
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+61521_481176593.0Topological domainLumenal
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+615482_502176593.0TransmembraneHelical
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+615482_502176593.0TransmembraneHelical
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+615482_502176593.0TransmembraneHelical
TgeneRUFY1chr5:179136060chr5:179020479ENST00000319449918321_374415709.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY1chr5:179136060chr5:179020479ENST00000319449918405_617415709.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY1chr5:179136060chr5:179020479ENST000003770011019321_374463522.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY1chr5:179136060chr5:179020479ENST000003770011019405_617463522.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY1chr5:179136060chr5:179020479ENST00000319449918139_271415709.0DomainRUN
TgeneRUFY1chr5:179136060chr5:179020479ENST000003770011019139_271463522.0DomainRUN
TgeneRUFY1chr5:179136060chr5:179020479ENST00000393438918139_271307601.0DomainRUN
TgeneRUFY1chr5:179136060chr5:179020479ENST00000437570817139_271307601.0DomainRUN


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Fusion Gene Sequence for CANX-RUFY1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12805_12805_1_CANX-RUFY1_CANX_chr5_179136060_ENST00000247461_RUFY1_chr5_179020479_ENST00000319449_length(transcript)=2117nt_BP=728nt
ACTCAGGGGCCAGGGGCGGGCACAGGGCCGGGCTTCGTGCGGTGGGGCTCGCTCGCGCGGCAGCGGTGGCCGAGGCCTCTTGGTTCTGCG
GCACGTGACGGTCGGGCCGCCTCCGCCTCTCTCTTTACTGCGGCGCGGGGCAAGGTGTGCGGGCGGGAAGGGGCACGGGCACCCCCGCGG
TCCCCGGGAGGCTAGAGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTGGTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGAC
ATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAGGTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTT
CATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTTGCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGA
TTTTATCCAAAGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGATGGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGC
TTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATCTCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCA
AGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGTGGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAAC
TCAACCTGGAACTGGAAAAAGAACTGGAGTTACAAATTGGAATGAAAACCGAAATGGAAATTGCAATGAAGTTACTGGAAAAGGACACCC
ACGAGAAGCAGGACACACTAGTTGCCCTCCGCCAGCAGCTGGAAGAAGTCAAAGCGATTAATTTACAGATGTTTCACAAAGCTCAGAATG
CAGAGAGCAGTTTGCAGCAGAAGAATGAAGCCATCACATCCTTTGAAGGAAAAACCAACCAAGTTATGTCCAGCATGAAACAAATGGAAG
AAAGGTTGCAGCACTCGGAGCGGGCGAGGCAGGGGGCTGAGGAGCGGAGCCACAAGCTGCAGCAGGAGCTGGGCGGGAGGATCGGCGCCC
TGCAGCTGCAGCTCTCCCAGCTGCACGAGCAATGCTCAAGCCTGGAGAAAGAATTGAAATCAGAAAAAGAGCAAAGACAGGCTCTTCAGC
GCGAATTACAGCACGAGAAAGACACTTCCTCTCTACTCAGGATGGAGCTGCAACAAGTGGAAGGACTGAAAAAGGAGTTGCGGGAGCTTC
AGGACGAGAAGGCAGAGCTGCAGAAGATCTGCGAGGAGCAGGAACAAGCCCTCCAGGAAATGGGCCTGCACCTCAGCCAGTCCAAGCTGA
AGATGGAAGATATAAAAGAAGTGAACCAGGCACTGAAGGGCCACGCCTGGCTGAAAGATGACGAAGCGACACACTGTAGGCAGTGTGAGA
AGGAGTTCTCCATTTCCCGGAGAAAGCACCACTGCCGGAACTGTGGCCACATCTTCTGCAACACCTGCTCCAGCAACGAGCTGGCCCTGC
CCTCCTACCCCAAGCCGGTGCGAGTGTGCGACAGCTGCCACACCCTGCTCCTGCAGCGCTGCTCCTCCACGGCCTCCTGAACGTCCGTCC
TCAGGAGCACAGCCTCACGGACAGTGCCAAACCCTGTGGGTCTCCAGGGGCTTGGGAAATGTGTTCTTTCCCAAGAGTATCAAAGGAAAG
AATCAAATTTCTTGCCCGGTCACTGGCACTCCAGAAGACAGCGTGCCGGAACCGGCAGCTCTCACCTTTCTGTGACTTGTTCGGAATTAA
CTCCTCTGGATGGAAACTTCCATCTTACTTGGTTACATCACGGCTCTGGTTCAGATACAACTTCATGATTTTGCTACTATCATTTTTCAC
TTTTCAAAGAATTTAACCTATTTTACAGCAGTTCAGTTCTGCTAGTGAGTAGTTTTCCTCTCCTACCTTCCTTCTAAAAACCTGATTCAT
GCACAGCGTTTGACACACATGGAGTCTGCCAGTGTGCCTTCTCTGCTTCAGACAAGAGATCTGCCATTTCATGCCCTTGTGACTACCTAT
CATTGGCCCTGCAATAAAATCATTTATTTTTCACTCTGGTGCGTGCA

>12805_12805_1_CANX-RUFY1_CANX_chr5_179136060_ENST00000247461_RUFY1_chr5_179020479_ENST00000319449_length(amino acids)=469AA_BP=176
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKK
DDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLELEK
ELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSE
RARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAEL
QKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPV
RVCDSCHTLLLQRCSSTAS

--------------------------------------------------------------
>12805_12805_2_CANX-RUFY1_CANX_chr5_179136060_ENST00000415618_RUFY1_chr5_179020479_ENST00000319449_length(transcript)=2097nt_BP=708nt
AATCCGGCCAGGCGCTCGCGCTGGGTTCTGCTCACGCCCGTAGGGGCCCGCGTTCGCTGCAACGGGCCCTTCCTGATGGCCGATCGTCGG
ACTCCTACCCCTTTTGCCGGCTGCCGTTTGCCCCGTCAGCGAAGGGCGCGCGATGCGTCCCAAGTCTCGGCTCCAGGAACCAGACGGATC
ATGGAAGGGAAGTGGTTGCTGTGTATGTTACTGGTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGACATGATGATGATGTGATTGAT
ATTGAGGATGACCTTGACGATGTCATTGAAGAGGTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTTCATCTCCCAAGGTTACTTAC
AAAGCTCCAGTTCCAACAGGGGAAGTATATTTTGCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGATTTTATCCAAAGCCAAGAAA
GACGATACCGATGATGAAATTGCCAAATATGATGGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGCTTCCAGGTGATAAAGGACTT
GTGTTGATGTCTCGGGCCAAGCATCATGCCATCTCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCAAGCCTCTCATTGTTCAGTAT
GAGGTTAATTTCCAAAATGGAATAGAATGTGGTGGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAACTCAACCTGGAACTGGAAAAA
GAACTGGAGTTACAAATTGGAATGAAAACCGAAATGGAAATTGCAATGAAGTTACTGGAAAAGGACACCCACGAGAAGCAGGACACACTA
GTTGCCCTCCGCCAGCAGCTGGAAGAAGTCAAAGCGATTAATTTACAGATGTTTCACAAAGCTCAGAATGCAGAGAGCAGTTTGCAGCAG
AAGAATGAAGCCATCACATCCTTTGAAGGAAAAACCAACCAAGTTATGTCCAGCATGAAACAAATGGAAGAAAGGTTGCAGCACTCGGAG
CGGGCGAGGCAGGGGGCTGAGGAGCGGAGCCACAAGCTGCAGCAGGAGCTGGGCGGGAGGATCGGCGCCCTGCAGCTGCAGCTCTCCCAG
CTGCACGAGCAATGCTCAAGCCTGGAGAAAGAATTGAAATCAGAAAAAGAGCAAAGACAGGCTCTTCAGCGCGAATTACAGCACGAGAAA
GACACTTCCTCTCTACTCAGGATGGAGCTGCAACAAGTGGAAGGACTGAAAAAGGAGTTGCGGGAGCTTCAGGACGAGAAGGCAGAGCTG
CAGAAGATCTGCGAGGAGCAGGAACAAGCCCTCCAGGAAATGGGCCTGCACCTCAGCCAGTCCAAGCTGAAGATGGAAGATATAAAAGAA
GTGAACCAGGCACTGAAGGGCCACGCCTGGCTGAAAGATGACGAAGCGACACACTGTAGGCAGTGTGAGAAGGAGTTCTCCATTTCCCGG
AGAAAGCACCACTGCCGGAACTGTGGCCACATCTTCTGCAACACCTGCTCCAGCAACGAGCTGGCCCTGCCCTCCTACCCCAAGCCGGTG
CGAGTGTGCGACAGCTGCCACACCCTGCTCCTGCAGCGCTGCTCCTCCACGGCCTCCTGAACGTCCGTCCTCAGGAGCACAGCCTCACGG
ACAGTGCCAAACCCTGTGGGTCTCCAGGGGCTTGGGAAATGTGTTCTTTCCCAAGAGTATCAAAGGAAAGAATCAAATTTCTTGCCCGGT
CACTGGCACTCCAGAAGACAGCGTGCCGGAACCGGCAGCTCTCACCTTTCTGTGACTTGTTCGGAATTAACTCCTCTGGATGGAAACTTC
CATCTTACTTGGTTACATCACGGCTCTGGTTCAGATACAACTTCATGATTTTGCTACTATCATTTTTCACTTTTCAAAGAATTTAACCTA
TTTTACAGCAGTTCAGTTCTGCTAGTGAGTAGTTTTCCTCTCCTACCTTCCTTCTAAAAACCTGATTCATGCACAGCGTTTGACACACAT
GGAGTCTGCCAGTGTGCCTTCTCTGCTTCAGACAAGAGATCTGCCATTTCATGCCCTTGTGACTACCTATCATTGGCCCTGCAATAAAAT
CATTTATTTTTCACTCTGGTGCGTGCA

>12805_12805_2_CANX-RUFY1_CANX_chr5_179136060_ENST00000415618_RUFY1_chr5_179020479_ENST00000319449_length(amino acids)=520AA_BP=227
MLTPVGARVRCNGPFLMADRRTPTPFAGCRLPRQRRARDASQVSAPGTRRIMEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVI
EEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHH
AISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEE
VKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE
KELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHA
WLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS

--------------------------------------------------------------
>12805_12805_3_CANX-RUFY1_CANX_chr5_179136060_ENST00000452673_RUFY1_chr5_179020479_ENST00000319449_length(transcript)=2064nt_BP=675nt
ACTCAGGGGCCAGGGGCGGGCACAGGGCCGGGCTTCGTGCGGTGGGGCTCGCTCGCGCGGCAGCGGTGGCCGAGGCCTCTTGGTTCTGCG
GCACGTGACGGTCGGGCCGCCTCCGCCTCTCTCTTTACTGCGGCGCGGGGCAAGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTG
GTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGACATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAG
GTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTTCATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTT
GCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGATTTTATCCAAAGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGAT
GGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGCTTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATC
TCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCAAGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGT
GGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAACTCAACCTGGAACTGGAAAAAGAACTGGAGTTACAAATTGGAATGAAAACCGAA
ATGGAAATTGCAATGAAGTTACTGGAAAAGGACACCCACGAGAAGCAGGACACACTAGTTGCCCTCCGCCAGCAGCTGGAAGAAGTCAAA
GCGATTAATTTACAGATGTTTCACAAAGCTCAGAATGCAGAGAGCAGTTTGCAGCAGAAGAATGAAGCCATCACATCCTTTGAAGGAAAA
ACCAACCAAGTTATGTCCAGCATGAAACAAATGGAAGAAAGGTTGCAGCACTCGGAGCGGGCGAGGCAGGGGGCTGAGGAGCGGAGCCAC
AAGCTGCAGCAGGAGCTGGGCGGGAGGATCGGCGCCCTGCAGCTGCAGCTCTCCCAGCTGCACGAGCAATGCTCAAGCCTGGAGAAAGAA
TTGAAATCAGAAAAAGAGCAAAGACAGGCTCTTCAGCGCGAATTACAGCACGAGAAAGACACTTCCTCTCTACTCAGGATGGAGCTGCAA
CAAGTGGAAGGACTGAAAAAGGAGTTGCGGGAGCTTCAGGACGAGAAGGCAGAGCTGCAGAAGATCTGCGAGGAGCAGGAACAAGCCCTC
CAGGAAATGGGCCTGCACCTCAGCCAGTCCAAGCTGAAGATGGAAGATATAAAAGAAGTGAACCAGGCACTGAAGGGCCACGCCTGGCTG
AAAGATGACGAAGCGACACACTGTAGGCAGTGTGAGAAGGAGTTCTCCATTTCCCGGAGAAAGCACCACTGCCGGAACTGTGGCCACATC
TTCTGCAACACCTGCTCCAGCAACGAGCTGGCCCTGCCCTCCTACCCCAAGCCGGTGCGAGTGTGCGACAGCTGCCACACCCTGCTCCTG
CAGCGCTGCTCCTCCACGGCCTCCTGAACGTCCGTCCTCAGGAGCACAGCCTCACGGACAGTGCCAAACCCTGTGGGTCTCCAGGGGCTT
GGGAAATGTGTTCTTTCCCAAGAGTATCAAAGGAAAGAATCAAATTTCTTGCCCGGTCACTGGCACTCCAGAAGACAGCGTGCCGGAACC
GGCAGCTCTCACCTTTCTGTGACTTGTTCGGAATTAACTCCTCTGGATGGAAACTTCCATCTTACTTGGTTACATCACGGCTCTGGTTCA
GATACAACTTCATGATTTTGCTACTATCATTTTTCACTTTTCAAAGAATTTAACCTATTTTACAGCAGTTCAGTTCTGCTAGTGAGTAGT
TTTCCTCTCCTACCTTCCTTCTAAAAACCTGATTCATGCACAGCGTTTGACACACATGGAGTCTGCCAGTGTGCCTTCTCTGCTTCAGAC
AAGAGATCTGCCATTTCATGCCCTTGTGACTACCTATCATTGGCCCTGCAATAAAATCATTTATTTTTCACTCTGGTGCGTGCA

>12805_12805_3_CANX-RUFY1_CANX_chr5_179136060_ENST00000452673_RUFY1_chr5_179020479_ENST00000319449_length(amino acids)=469AA_BP=176
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKK
DDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLELEK
ELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSE
RARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAEL
QKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPV
RVCDSCHTLLLQRCSSTAS

--------------------------------------------------------------
>12805_12805_4_CANX-RUFY1_CANX_chr5_179136060_ENST00000504734_RUFY1_chr5_179020479_ENST00000319449_length(transcript)=2107nt_BP=718nt
AGTGCACGCCAATCCGGCCAGGCGCTCGCGCTGGGTTCTGCTCACGCCCGTAGGGGCCCGCGTTCGCTGCAACGGGCCCTTCCTGATGGC
CGATCGTCGGACTCCTACCCCTTTTGCCGGCTGCCGTTTGCCCCGTCAGCGAAGGGCGCGCGATGCGTCCCAAGTCTCGGCTCCAGGAAC
CAGACGGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTGGTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGACATGATGATGA
TGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAGGTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTTCATCTCCCAA
GGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTTGCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGATTTTATCCAA
AGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGATGGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGCTTCCAGGTGA
TAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATCTCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCAAGCCTCTCAT
TGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGTGGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAACTCAACCTGGA
ACTGGAAAAAGAACTGGAGTTACAAATTGGAATGAAAACCGAAATGGAAATTGCAATGAAGTTACTGGAAAAGGACACCCACGAGAAGCA
GGACACACTAGTTGCCCTCCGCCAGCAGCTGGAAGAAGTCAAAGCGATTAATTTACAGATGTTTCACAAAGCTCAGAATGCAGAGAGCAG
TTTGCAGCAGAAGAATGAAGCCATCACATCCTTTGAAGGAAAAACCAACCAAGTTATGTCCAGCATGAAACAAATGGAAGAAAGGTTGCA
GCACTCGGAGCGGGCGAGGCAGGGGGCTGAGGAGCGGAGCCACAAGCTGCAGCAGGAGCTGGGCGGGAGGATCGGCGCCCTGCAGCTGCA
GCTCTCCCAGCTGCACGAGCAATGCTCAAGCCTGGAGAAAGAATTGAAATCAGAAAAAGAGCAAAGACAGGCTCTTCAGCGCGAATTACA
GCACGAGAAAGACACTTCCTCTCTACTCAGGATGGAGCTGCAACAAGTGGAAGGACTGAAAAAGGAGTTGCGGGAGCTTCAGGACGAGAA
GGCAGAGCTGCAGAAGATCTGCGAGGAGCAGGAACAAGCCCTCCAGGAAATGGGCCTGCACCTCAGCCAGTCCAAGCTGAAGATGGAAGA
TATAAAAGAAGTGAACCAGGCACTGAAGGGCCACGCCTGGCTGAAAGATGACGAAGCGACACACTGTAGGCAGTGTGAGAAGGAGTTCTC
CATTTCCCGGAGAAAGCACCACTGCCGGAACTGTGGCCACATCTTCTGCAACACCTGCTCCAGCAACGAGCTGGCCCTGCCCTCCTACCC
CAAGCCGGTGCGAGTGTGCGACAGCTGCCACACCCTGCTCCTGCAGCGCTGCTCCTCCACGGCCTCCTGAACGTCCGTCCTCAGGAGCAC
AGCCTCACGGACAGTGCCAAACCCTGTGGGTCTCCAGGGGCTTGGGAAATGTGTTCTTTCCCAAGAGTATCAAAGGAAAGAATCAAATTT
CTTGCCCGGTCACTGGCACTCCAGAAGACAGCGTGCCGGAACCGGCAGCTCTCACCTTTCTGTGACTTGTTCGGAATTAACTCCTCTGGA
TGGAAACTTCCATCTTACTTGGTTACATCACGGCTCTGGTTCAGATACAACTTCATGATTTTGCTACTATCATTTTTCACTTTTCAAAGA
ATTTAACCTATTTTACAGCAGTTCAGTTCTGCTAGTGAGTAGTTTTCCTCTCCTACCTTCCTTCTAAAAACCTGATTCATGCACAGCGTT
TGACACACATGGAGTCTGCCAGTGTGCCTTCTCTGCTTCAGACAAGAGATCTGCCATTTCATGCCCTTGTGACTACCTATCATTGGCCCT
GCAATAAAATCATTTATTTTTCACTCTGGTGCGTGCA

>12805_12805_4_CANX-RUFY1_CANX_chr5_179136060_ENST00000504734_RUFY1_chr5_179020479_ENST00000319449_length(amino acids)=520AA_BP=227
MLTPVGARVRCNGPFLMADRRTPTPFAGCRLPRQRRARDASQVSAPGTRRIMEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVI
EEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHH
AISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEE
VKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE
KELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHA
WLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS

--------------------------------------------------------------
>12805_12805_5_CANX-RUFY1_CANX_chr5_179136060_ENST00000512607_RUFY1_chr5_179020479_ENST00000319449_length(transcript)=1976nt_BP=587nt
GTTCTGCGGCACGTGACGGTCGGGCCGCCTCCGCCTCTCTCTTTACTGCGGCGCGGGGCAAGGTGTGCGGGCGGGAAGGGGCACGGGCAC
CCCCGCGGTCCCCGGGAGGCTAGAGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTGGTGCTTGGAACTGCTATTGTTGAGGCTCA
TGATGGACATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAGGTAGAAGACTCAAAACCAGATACCACTGC
TCCTCCTTCATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTTGCTGATTCTTTTGACAGAGGAACTCTGTC
AGGGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGCTTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCA
TCTCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCAAGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTG
GTGGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAACTCAACCTGGAACTGGAAAAAGAACTGGAGTTACAAATTGGAATGAAAACCG
AAATGGAAATTGCAATGAAGTTACTGGAAAAGGACACCCACGAGAAGCAGGACACACTAGTTGCCCTCCGCCAGCAGCTGGAAGAAGTCA
AAGCGATTAATTTACAGATGTTTCACAAAGCTCAGAATGCAGAGAGCAGTTTGCAGCAGAAGAATGAAGCCATCACATCCTTTGAAGGAA
AAACCAACCAAGTTATGTCCAGCATGAAACAAATGGAAGAAAGGTTGCAGCACTCGGAGCGGGCGAGGCAGGGGGCTGAGGAGCGGAGCC
ACAAGCTGCAGCAGGAGCTGGGCGGGAGGATCGGCGCCCTGCAGCTGCAGCTCTCCCAGCTGCACGAGCAATGCTCAAGCCTGGAGAAAG
AATTGAAATCAGAAAAAGAGCAAAGACAGGCTCTTCAGCGCGAATTACAGCACGAGAAAGACACTTCCTCTCTACTCAGGATGGAGCTGC
AACAAGTGGAAGGACTGAAAAAGGAGTTGCGGGAGCTTCAGGACGAGAAGGCAGAGCTGCAGAAGATCTGCGAGGAGCAGGAACAAGCCC
TCCAGGAAATGGGCCTGCACCTCAGCCAGTCCAAGCTGAAGATGGAAGATATAAAAGAAGTGAACCAGGCACTGAAGGGCCACGCCTGGC
TGAAAGATGACGAAGCGACACACTGTAGGCAGTGTGAGAAGGAGTTCTCCATTTCCCGGAGAAAGCACCACTGCCGGAACTGTGGCCACA
TCTTCTGCAACACCTGCTCCAGCAACGAGCTGGCCCTGCCCTCCTACCCCAAGCCGGTGCGAGTGTGCGACAGCTGCCACACCCTGCTCC
TGCAGCGCTGCTCCTCCACGGCCTCCTGAACGTCCGTCCTCAGGAGCACAGCCTCACGGACAGTGCCAAACCCTGTGGGTCTCCAGGGGC
TTGGGAAATGTGTTCTTTCCCAAGAGTATCAAAGGAAAGAATCAAATTTCTTGCCCGGTCACTGGCACTCCAGAAGACAGCGTGCCGGAA
CCGGCAGCTCTCACCTTTCTGTGACTTGTTCGGAATTAACTCCTCTGGATGGAAACTTCCATCTTACTTGGTTACATCACGGCTCTGGTT
CAGATACAACTTCATGATTTTGCTACTATCATTTTTCACTTTTCAAAGAATTTAACCTATTTTACAGCAGTTCAGTTCTGCTAGTGAGTA
GTTTTCCTCTCCTACCTTCCTTCTAAAAACCTGATTCATGCACAGCGTTTGACACACATGGAGTCTGCCAGTGTGCCTTCTCTGCTTCAG
ACAAGAGATCTGCCATTTCATGCCCTTGTGACTACCTATCATTGGCCCTGCAATAAAATCATTTATTTTTCACTCTGGTGCGTGCA

>12805_12805_5_CANX-RUFY1_CANX_chr5_179136060_ENST00000512607_RUFY1_chr5_179020479_ENST00000319449_length(amino acids)=400AA_BP=107
MLLLHLPRLLTKLQFQQGKYILLILLTEELCQGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIE
CGGAYVKLLSKTPELNLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFE
GKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRME
LQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCG
HIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS

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Fusion Gene PPI Analysis for CANX-RUFY1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRUFY1chr5:179136060chr5:179020479ENST00000319449918615_625415.0709.0RAB4
TgeneRUFY1chr5:179136060chr5:179020479ENST000003770011019615_625463.3333333333333522.0RAB4
TgeneRUFY1chr5:179136060chr5:179020479ENST00000393438918615_625307.0601.0RAB4
TgeneRUFY1chr5:179136060chr5:179020479ENST00000437570817615_625307.0601.0RAB4


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCANXchr5:179136060chr5:179020479ENST00000247461+615326_359176.0593.0PPIB
HgeneCANXchr5:179136060chr5:179020479ENST00000452673+615326_359176.0593.0PPIB
HgeneCANXchr5:179136060chr5:179020479ENST00000504734+615326_359176.0593.0PPIB


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CANX-RUFY1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCANXP27824DB00031TenecteplaseBiotechApproved
HgeneCANXP27824DB11348Calcium PhosphateLigandSmall moleculeApproved
HgeneCANXP27824DB13999Moroctocog alfaChaperoneBiotechApproved
HgeneCANXP27824DB14481Calcium phosphate dihydrateSmall moleculeApproved
HgeneCANXP27824DB00025Antihemophilic factor, human recombinantChaperoneBiotechApproved|Investigational
HgeneCANXP27824DB11093Calcium citrateLigandSmall moleculeApproved|Investigational
HgeneCANXP27824DB13998Lonoctocog alfaChaperoneBiotechApproved|Investigational

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Related Diseases for CANX-RUFY1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCANXC0019193Hepatitis, Toxic1CTD_human
HgeneCANXC0151744Myocardial Ischemia1CTD_human
HgeneCANXC0860207Drug-Induced Liver Disease1CTD_human
HgeneCANXC1262760Hepatitis, Drug-Induced1CTD_human
HgeneCANXC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneCANXC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneCANXC4279912Chemically-Induced Liver Toxicity1CTD_human