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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAPN2-SH2D1B (FusionGDB2 ID:HG824TG117157)

Fusion Gene Summary for CAPN2-SH2D1B

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPN2-SH2D1B
Fusion gene ID: hg824tg117157
HgeneTgene
Gene symbol

CAPN2

SH2D1B

Gene ID

824

117157

Gene namecalpain 2SH2 domain containing 1B
SynonymsCANP2|CANPL2|CANPml|mCANPEAT2
Cytomap('CAPN2')('SH2D1B')

1q41

1q23.3

Type of geneprotein-codingprotein-coding
Descriptioncalpain-2 catalytic subunitCANP 2M-calpaincalcium-activated neutral proteinase 2calpain 2, (m/II) large subunitcalpain 2, large [catalytic] subunitcalpain 2, large subunitcalpain M-typecalpain, large polypeptide L2millimolar-calpainSH2 domain-containing protein 1BEAT-2EWS/FLI1-activated transcript 2SH2 domain-containing molecule EAT2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000474026, ENST00000295006, 
ENST00000433674, 
Fusion gene scores* DoF score11 X 9 X 5=4954 X 4 X 3=48
# samples 114
** MAII scorelog2(11/495*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPN2 [Title/Abstract] AND SH2D1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAPN2(223954118)-SH2D1B(162368877), # samples:2
Anticipated loss of major functional domain due to fusion event.CAPN2-SH2D1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPN2-SH2D1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPN2-SH2D1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPN2-SH2D1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAPN2

GO:0051603

proteolysis involved in cellular protein catabolic process

12150984


check buttonFusion gene breakpoints across CAPN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SH2D1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A182-06ACAPN2chr1

223954118

+SH2D1Bchr1

162368877

-


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Fusion Gene ORF analysis for CAPN2-SH2D1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000474026ENST00000367929CAPN2chr1

223954118

+SH2D1Bchr1

162368877

-
3UTR-intronENST00000474026ENST00000359567CAPN2chr1

223954118

+SH2D1Bchr1

162368877

-
3UTR-intronENST00000474026ENST00000493550CAPN2chr1

223954118

+SH2D1Bchr1

162368877

-
5CDS-intronENST00000295006ENST00000359567CAPN2chr1

223954118

+SH2D1Bchr1

162368877

-
5CDS-intronENST00000295006ENST00000493550CAPN2chr1

223954118

+SH2D1Bchr1

162368877

-
5CDS-intronENST00000433674ENST00000359567CAPN2chr1

223954118

+SH2D1Bchr1

162368877

-
5CDS-intronENST00000433674ENST00000493550CAPN2chr1

223954118

+SH2D1Bchr1

162368877

-
In-frameENST00000295006ENST00000367929CAPN2chr1

223954118

+SH2D1Bchr1

162368877

-
In-frameENST00000433674ENST00000367929CAPN2chr1

223954118

+SH2D1Bchr1

162368877

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000433674CAPN2chr1223954118+ENST00000367929SH2D1Bchr1162368877-392217072271696489
ENST00000295006CAPN2chr1223954118+ENST00000367929SH2D1Bchr1162368877-422920143092003564

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000433674ENST00000367929CAPN2chr1223954118+SH2D1Bchr1162368877-0.0007984730.9992016
ENST00000295006ENST00000367929CAPN2chr1223954118+SH2D1Bchr1162368877-0.0006674860.9993325

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Fusion Genomic Features for CAPN2-SH2D1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CAPN2-SH2D1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:223954118/chr1:162368877)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSH2D1Bchr1:223954118chr1:162368877ENST00000359567035_101078.0DomainSH2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAPN2chr1:223954118chr1:162368877ENST00000295006+121585_5960701.0Calcium bindingNote=1
HgeneCAPN2chr1:223954118chr1:162368877ENST00000295006+121615_6260701.0Calcium bindingNote=2
HgeneCAPN2chr1:223954118chr1:162368877ENST00000433674+121585_5960623.0Calcium bindingNote=1
HgeneCAPN2chr1:223954118chr1:162368877ENST00000433674+121615_6260623.0Calcium bindingNote=2
HgeneCAPN2chr1:223954118chr1:162368877ENST00000295006+12145_3440701.0DomainCalpain catalytic
HgeneCAPN2chr1:223954118chr1:162368877ENST00000295006+121572_6050701.0DomainEF-hand 1
HgeneCAPN2chr1:223954118chr1:162368877ENST00000295006+121602_6370701.0DomainEF-hand 2
HgeneCAPN2chr1:223954118chr1:162368877ENST00000295006+121667_7000701.0DomainEF-hand 3
HgeneCAPN2chr1:223954118chr1:162368877ENST00000433674+12145_3440623.0DomainCalpain catalytic
HgeneCAPN2chr1:223954118chr1:162368877ENST00000433674+121572_6050623.0DomainEF-hand 1
HgeneCAPN2chr1:223954118chr1:162368877ENST00000433674+121602_6370623.0DomainEF-hand 2
HgeneCAPN2chr1:223954118chr1:162368877ENST00000433674+121667_7000623.0DomainEF-hand 3
HgeneCAPN2chr1:223954118chr1:162368877ENST00000295006+121345_5140701.0RegionNote=Domain III
HgeneCAPN2chr1:223954118chr1:162368877ENST00000295006+121515_5290701.0RegionNote=Linker
HgeneCAPN2chr1:223954118chr1:162368877ENST00000295006+121530_7000701.0RegionNote=Domain IV
HgeneCAPN2chr1:223954118chr1:162368877ENST00000433674+121345_5140623.0RegionNote=Domain III
HgeneCAPN2chr1:223954118chr1:162368877ENST00000433674+121515_5290623.0RegionNote=Linker
HgeneCAPN2chr1:223954118chr1:162368877ENST00000433674+121530_7000623.0RegionNote=Domain IV
TgeneSH2D1Bchr1:223954118chr1:162368877ENST00000367929145_10166133.0DomainSH2


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Fusion Gene Sequence for CAPN2-SH2D1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12877_12877_1_CAPN2-SH2D1B_CAPN2_chr1_223954118_ENST00000295006_SH2D1B_chr1_162368877_ENST00000367929_length(transcript)=4229nt_BP=2014nt
CCTCCCCGGCGCCGGGCCGCGCCATCCCGGGAGCTGTCCGCAGATGGCAGCACCGGCCCCGGGTCGCGGCGTTCCCGGCGCTCGGCAGGC
CGCAGGATGGCCTGGTCCCGGGCCGGGAGCCCAGCAGGCCGGGAGCGGCTGAGGCCACACCCCGCGGGCCGGGCCGCTTCCCTCCGGTGA
ATCATCGCTCGCAGCGGCGGCGCCCGCAGTGGCCGCAGCAGCGCGCCGGGCCCTGGCCGCGCCCCAGCCGAGCGCAGCGCGGAGTCGCCC
CGACCTTTCTCTGCGCAGTACGGCCGCCGGGACCGCAGCATGGCGGGCATCGCGGCCAAGCTGGCGAAGGACCGGGAGGCGGCCGAGGGG
CTGGGCTCCCACGACAGGGCCATCAAGTACCTCAACCAGGACTACGAGGCGCTGCGGAACGAGTGCCTGGAGGCCGGGACGCTCTTCCAG
GACCCGTCCTTCCCGGCCATCCCCTCGGCCCTGGGCTTCAAGGAGTTGGGGCCCTACTCCAGCAAAACCCGGGGCATCGAGTGGAAGCGC
CCCACGGAGATCTGCGCTGACCCCCAGTTTATCATTGGAGGAGCCACCCGCACAGACATCTGCCAAGGAGCCCTGGGTGACTGCTGGCTG
CTGGCAGCCATTGCCTCCCTCACCTTGAATGAAGAAATCCTGGCTCGAGTCGTCCCCCTAAACCAGAGCTTCCAGGAAAACTATGCAGGG
ATCTTTCACTTCCAGTTCTGGCAATACGGCGAGTGGGTGGAGGTGGTGGTGGATGACAGGCTGCCCACCAAGGACGGGGAGCTGCTCTTT
GTGCATTCAGCCGAAGGGAGCGAGTTCTGGAGCGCCCTGCTGGAGAAGGCATACGCCAAGATCAACGGATGCTATGAAGCGCTATCAGGG
GGTGCCACCACTGAGGGCTTCGAAGACTTCACCGGAGGCATTGCTGAGTGGTATGAGTTGAAGAAGCCCCCTCCCAACCTGTTCAAGATC
ATCCAGAAAGCTCTGCAAAAAGGCTCTCTCCTTGGCTGCTCCATCGACATCACCAGCGCCGCGGACTCGGAGGCCATCACGTTTCAGAAG
CTGGTGAAGGGGCACGCGTACTCGGTCACCGGAGCCGAGGAGGTTGAAAGTAACGGAAGCCTACAGAAACTGATCCGCATCCGAAATCCC
TGGGGAGAAGTGGAGTGGACAGGGCGGTGGAATGACAACTGCCCAAGCTGGAACACTATAGACCCAGAGGAGAGGGAAAGGCTGACCAGA
CGGCATGAAGATGGAGAATTCTGGATGTCTTTCAGTGACTTCCTGAGGCACTATTCCCGCCTGGAGATCTGTAACCTGACCCCAGACACT
CTCACCAGCGATACCTACAAGAAGTGGAAACTCACCAAAATGGATGGGAACTGGAGGCGGGGCTCCACCGCGGGAGGTTGCAGGAACTAC
CCGAACACATTCTGGATGAACCCTCAGTACCTGATCAAGCTGGAGGAGGAGGATGAGGACGAGGAGGATGGGGAGAGCGGCTGCACCTTC
CTGGTGGGGCTCATTCAGAAGCACCGACGGCGGCAGAGGAAGATGGGCGAGGACATGCACACCATCGGCTTTGGCATCTATGAGGTTCCA
GAGGAGTTAAGTGGGCAGACCAACATCCACCTCAGCAAAAACTTCTTCCTGACGAATCGCGCCAGGGAGCGCTCAGACACCTTCATCAAC
CTCCGGGAGGTGCTCAACCGCTTCAAGCTGCCGCCAGGAGAGTACATTCTCGTGCCTTCCACCTTCGAACCCAACAAGGATGGGGATTTC
TGCATCCGGGTCTTTTCTGAAAAGAAAGCTGACTACCAAGCTGTCGATGATGAAATCGAGGCCAATCTTGAAGAGTTCGACATCAGCGAG
GATGACATTGATGATGGATTCAGGAGACTGTTTGCCCAGTTGGCAGGAGAGGATGCGGAGATCTCTGCCTTTGAGCTGCAGACCATCCTG
AGAAGGGTTCTAGCAAAGCGTTGACATGCTAGATACTGCAGAAGGTTCTCCAAAACAGGTCTTTCCAAGCCTAAAGGAACTGATCTCCAA
ATTTGAAAAACCAAATCAGGGGATGGTGGTTCACCTTTTAAAGCCAATAAAGAGAACCAGCCCCAGCTTGAGATGGAGAGGATTGAAATT
AGAGTTGGAAACATTTGTGAACAGTAACAGCGATTATGTGGATGTCTTGCCTTGAAGATAAGGCTGCCGGACAAAGCAAGTTGAAGAGAT
GAGTAACAGTTCTCACTGATGACCCACTTCTGCAGGCATAGGTCCAGAGCACCAAACTCTAGTGGACAATTCAGACTCTCCTGGTTGTGT
AACTGAAGATGTTCTGCCCACCAGCACCAGAGGTCACTCTCCACATCCCCGCCTCCCAGACATATACCAGGAGCAATTTCAAAACCCTCT
CCAGTTTCACTCTTCTTTCTTGGAATGGGACAGCCTGAACATTTTCCCTTTGACTTGTTAAAGGTACCACCCTACATCATGGTTGACACC
CTCCTTTGGACCATGCAGTCAGAGGGGCAGCTTTATACAGAGGAGGGGCACACTTGTCTGTGAGTTTGAAGCCCTGAGTTCCAGTCCTGT
GGCTGTGTGACTTTGAACACGTTTCTGCCCATCTCCAGGTCTTAGTTTCTTTGTCTCTGTGGTTGGGTGGGATGATAAACATTGCCCCAG
TCTCTCTGTTGAGCCTGCTTGTGTCAGGTGAAGGTGAGGGATCGGGAGTGATGGAGATGCATACAGATCAGCACCTTCTCTGTACCTGCT
GGACCCCCATGTGCACCCTTCTCCCTCCAGCCTGGGCTACTCTCCTCCTGGTTCTTTCTAATCTTAAACTTCCTGGTGAGCATTGCCCCA
GCCACACTTTCTCCCTGGTTTTGCTTAATTCCACTTATGCATCAGTCATTTCAACAGCATGAATGTGGTTCTGTACAGTGATGTATGTGG
AGATTTCTAAAATATTCTATGTGTGATTTCTGTTCCCAACTAGGTTCTAAGTGCCATCAAAGCACGGTTGGGTCTCCCTTGTATCTTCCA
CAGTGTGTAGAAATTTGTGCTGCCCAGAGCTGTGCCTAGTTCATAGAAACTGACTGGAAGCACATTGCTGAGGGAGGTTTGTTGAATTGG
TTTTTAAGGTTTACTGAAATTGATTTGCTGAATTTTTCTGCTAGTTCAAAATGTGAATTAGGACCTGGTCAGTTTGAAATATACCAAATT
CTATGCCCTTTCTCTTACCTATCATCAAATTGTAGTAATGTATTTCACCCCACTGGACTTATCTTCAGAGTTTTAAAAGAGAGGAGCTCT
CGACTTAGAGGTAATATGAACAGATGAACAGACACTGTGGCTGGAGCCCCAAAGTGTGGAGCATTGTGAGATTTGGGGTCACAGCAATTT
ATGGCTACTATTCCCTGGGTCTGGTAGGTAGGACAAATGTCCTCTTTTACTTTTCAAAACTGGCTTAGGTATTCATGGACCTTGATTCTT
CTATATACATTTTATAATAAATACGTGAAATTGCTTAAAACCTCTTTTTGGAATTTTTAATGAACTTGCAACAAATTTGTAAATAGGAGA
GAACTGACGTTCTTGTGATGTTTTCCCATGCATAAACATGCCACATCCATGTTCTTGGGTCATCTTTTTTGCCCTTTCATGGAGTCATAA
ATTTTCCCAACTGAAGTCTTGTATATTCTGTTAGATTAATTCCTATTTCTAGTTGCTGTAAATGATATCTTATGTTTTATTACATTTCTA
ATAGGATATGGTGTTGGTGAAATGTTAACCCTCTCATTAGATCTACTAGTTTACCTGTTGATTCTATTGTGTTTTCTATGTAAATGATTT
TGTCAGCTATAAATAATAACATTTTATTTTCTCTTTCCTTGCAATACCTATGCTCATTTATTTTTTATGTTTACCCATTGGTTAGGGCCT
CCTGTATACATTAAACAGTTCATAGTCATGATAGTGAGTATTCTTACACTGTTCCCAGTATTACAGGGAATGCTTAGAAATTTTCTTTAT
TTAAACATTATGTTTGTTGTAGCCTTGTTAAAGGCTATTTTATAATTTTTACTAGAAATATTTTGACATTTATTGTGATTTTTTTCTATC
TCTAATCTATTGAGATAGTCACATTCCTTTTGTCTTCACTCCATTATAAAGGTAAGTTACCTTAATAAAATTGTTGATATCATTTCATC

>12877_12877_1_CAPN2-SH2D1B_CAPN2_chr1_223954118_ENST00000295006_SH2D1B_chr1_162368877_ENST00000367929_length(amino acids)=564AA_BP=
MAGIAAKLAKDREAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIG
GATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL
LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGAE
EVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTK
MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSK
NFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQ
LAGEDAEISAFELQTILRRVLAKR

--------------------------------------------------------------
>12877_12877_2_CAPN2-SH2D1B_CAPN2_chr1_223954118_ENST00000433674_SH2D1B_chr1_162368877_ENST00000367929_length(transcript)=3922nt_BP=1707nt
ACTCAGACTCTGATGGCTCTGTAGCTAACTGGCCCATCCTCAGAGACTAACGCAAAGGAACGAATTTCCAGGATGTTCGACTATGTGGAG
AAAACAAAAAAAAAGCAAAGAAAAAAATATTTTTAAAGAAAGAAAGAAGGCCAGGTGCAGTGGTTCACGCCTGTAATCCCAACACTTTGG
GAGGCCGAGGCAGACAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGAGATCTGCGCTGACCCCCAGTTTATCATTG
GAGGAGCCACCCGCACAGACATCTGCCAAGGAGCCCTGGGTGACTGCTGGCTGCTGGCAGCCATTGCCTCCCTCACCTTGAATGAAGAAA
TCCTGGCTCGAGTCGTCCCCCTAAACCAGAGCTTCCAGGAAAACTATGCAGGGATCTTTCACTTCCAGTTCTGGCAATACGGCGAGTGGG
TGGAGGTGGTGGTGGATGACAGGCTGCCCACCAAGGACGGGGAGCTGCTCTTTGTGCATTCAGCCGAAGGGAGCGAGTTCTGGAGCGCCC
TGCTGGAGAAGGCATACGCCAAGATCAACGGATGCTATGAAGCGCTATCAGGGGGTGCCACCACTGAGGGCTTCGAAGACTTCACCGGAG
GCATTGCTGAGTGGTATGAGTTGAAGAAGCCCCCTCCCAACCTGTTCAAGATCATCCAGAAAGCTCTGCAAAAAGGCTCTCTCCTTGGCT
GCTCCATCGACATCACCAGCGCCGCGGACTCGGAGGCCATCACGTTTCAGAAGCTGGTGAAGGGGCACGCGTACTCGGTCACCGGAGCCG
AGGAGGTTGAAAGTAACGGAAGCCTACAGAAACTGATCCGCATCCGAAATCCCTGGGGAGAAGTGGAGTGGACAGGGCGGTGGAATGACA
ACTGCCCAAGCTGGAACACTATAGACCCAGAGGAGAGGGAAAGGCTGACCAGACGGCATGAAGATGGAGAATTCTGGATGTCTTTCAGTG
ACTTCCTGAGGCACTATTCCCGCCTGGAGATCTGTAACCTGACCCCAGACACTCTCACCAGCGATACCTACAAGAAGTGGAAACTCACCA
AAATGGATGGGAACTGGAGGCGGGGCTCCACCGCGGGAGGTTGCAGGAACTACCCGAACACATTCTGGATGAACCCTCAGTACCTGATCA
AGCTGGAGGAGGAGGATGAGGACGAGGAGGATGGGGAGAGCGGCTGCACCTTCCTGGTGGGGCTCATTCAGAAGCACCGACGGCGGCAGA
GGAAGATGGGCGAGGACATGCACACCATCGGCTTTGGCATCTATGAGGTTCCAGAGGAGTTAAGTGGGCAGACCAACATCCACCTCAGCA
AAAACTTCTTCCTGACGAATCGCGCCAGGGAGCGCTCAGACACCTTCATCAACCTCCGGGAGGTGCTCAACCGCTTCAAGCTGCCGCCAG
GAGAGTACATTCTCGTGCCTTCCACCTTCGAACCCAACAAGGATGGGGATTTCTGCATCCGGGTCTTTTCTGAAAAGAAAGCTGACTACC
AAGCTGTCGATGATGAAATCGAGGCCAATCTTGAAGAGTTCGACATCAGCGAGGATGACATTGATGATGGATTCAGGAGACTGTTTGCCC
AGTTGGCAGGAGAGGATGCGGAGATCTCTGCCTTTGAGCTGCAGACCATCCTGAGAAGGGTTCTAGCAAAGCGTTGACATGCTAGATACT
GCAGAAGGTTCTCCAAAACAGGTCTTTCCAAGCCTAAAGGAACTGATCTCCAAATTTGAAAAACCAAATCAGGGGATGGTGGTTCACCTT
TTAAAGCCAATAAAGAGAACCAGCCCCAGCTTGAGATGGAGAGGATTGAAATTAGAGTTGGAAACATTTGTGAACAGTAACAGCGATTAT
GTGGATGTCTTGCCTTGAAGATAAGGCTGCCGGACAAAGCAAGTTGAAGAGATGAGTAACAGTTCTCACTGATGACCCACTTCTGCAGGC
ATAGGTCCAGAGCACCAAACTCTAGTGGACAATTCAGACTCTCCTGGTTGTGTAACTGAAGATGTTCTGCCCACCAGCACCAGAGGTCAC
TCTCCACATCCCCGCCTCCCAGACATATACCAGGAGCAATTTCAAAACCCTCTCCAGTTTCACTCTTCTTTCTTGGAATGGGACAGCCTG
AACATTTTCCCTTTGACTTGTTAAAGGTACCACCCTACATCATGGTTGACACCCTCCTTTGGACCATGCAGTCAGAGGGGCAGCTTTATA
CAGAGGAGGGGCACACTTGTCTGTGAGTTTGAAGCCCTGAGTTCCAGTCCTGTGGCTGTGTGACTTTGAACACGTTTCTGCCCATCTCCA
GGTCTTAGTTTCTTTGTCTCTGTGGTTGGGTGGGATGATAAACATTGCCCCAGTCTCTCTGTTGAGCCTGCTTGTGTCAGGTGAAGGTGA
GGGATCGGGAGTGATGGAGATGCATACAGATCAGCACCTTCTCTGTACCTGCTGGACCCCCATGTGCACCCTTCTCCCTCCAGCCTGGGC
TACTCTCCTCCTGGTTCTTTCTAATCTTAAACTTCCTGGTGAGCATTGCCCCAGCCACACTTTCTCCCTGGTTTTGCTTAATTCCACTTA
TGCATCAGTCATTTCAACAGCATGAATGTGGTTCTGTACAGTGATGTATGTGGAGATTTCTAAAATATTCTATGTGTGATTTCTGTTCCC
AACTAGGTTCTAAGTGCCATCAAAGCACGGTTGGGTCTCCCTTGTATCTTCCACAGTGTGTAGAAATTTGTGCTGCCCAGAGCTGTGCCT
AGTTCATAGAAACTGACTGGAAGCACATTGCTGAGGGAGGTTTGTTGAATTGGTTTTTAAGGTTTACTGAAATTGATTTGCTGAATTTTT
CTGCTAGTTCAAAATGTGAATTAGGACCTGGTCAGTTTGAAATATACCAAATTCTATGCCCTTTCTCTTACCTATCATCAAATTGTAGTA
ATGTATTTCACCCCACTGGACTTATCTTCAGAGTTTTAAAAGAGAGGAGCTCTCGACTTAGAGGTAATATGAACAGATGAACAGACACTG
TGGCTGGAGCCCCAAAGTGTGGAGCATTGTGAGATTTGGGGTCACAGCAATTTATGGCTACTATTCCCTGGGTCTGGTAGGTAGGACAAA
TGTCCTCTTTTACTTTTCAAAACTGGCTTAGGTATTCATGGACCTTGATTCTTCTATATACATTTTATAATAAATACGTGAAATTGCTTA
AAACCTCTTTTTGGAATTTTTAATGAACTTGCAACAAATTTGTAAATAGGAGAGAACTGACGTTCTTGTGATGTTTTCCCATGCATAAAC
ATGCCACATCCATGTTCTTGGGTCATCTTTTTTGCCCTTTCATGGAGTCATAAATTTTCCCAACTGAAGTCTTGTATATTCTGTTAGATT
AATTCCTATTTCTAGTTGCTGTAAATGATATCTTATGTTTTATTACATTTCTAATAGGATATGGTGTTGGTGAAATGTTAACCCTCTCAT
TAGATCTACTAGTTTACCTGTTGATTCTATTGTGTTTTCTATGTAAATGATTTTGTCAGCTATAAATAATAACATTTTATTTTCTCTTTC
CTTGCAATACCTATGCTCATTTATTTTTTATGTTTACCCATTGGTTAGGGCCTCCTGTATACATTAAACAGTTCATAGTCATGATAGTGA
GTATTCTTACACTGTTCCCAGTATTACAGGGAATGCTTAGAAATTTTCTTTATTTAAACATTATGTTTGTTGTAGCCTTGTTAAAGGCTA
TTTTATAATTTTTACTAGAAATATTTTGACATTTATTGTGATTTTTTTCTATCTCTAATCTATTGAGATAGTCACATTCCTTTTGTCTTC
ACTCCATTATAAAGGTAAGTTACCTTAATAAAATTGTTGATATCATTTCATC

>12877_12877_2_CAPN2-SH2D1B_CAPN2_chr1_223954118_ENST00000433674_SH2D1B_chr1_162368877_ENST00000367929_length(amino acids)=489AA_BP=
MANMEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGEL
LFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITF
QKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTP
DTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYE
VPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDI
SEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKR

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Fusion Gene PPI Analysis for CAPN2-SH2D1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAPN2-SH2D1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAPN2-SH2D1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCAPN2C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneCAPN2C0026998Acute Myeloid Leukemia, M11CTD_human
HgeneCAPN2C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human