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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAPNS1-MTA2 (FusionGDB2 ID:HG826TG9219)

Fusion Gene Summary for CAPNS1-MTA2

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPNS1-MTA2
Fusion gene ID: hg826tg9219
HgeneTgene
Gene symbol

CAPNS1

MTA2

Gene ID

826

9219

Gene namecalpain small subunit 1metastasis associated 1 family member 2
SynonymsCALPAIN4|CANP|CANPS|CAPN4|CDPS|CSS1MTA1L1|PID
Cytomap('CAPNS1')('MTA2')

19q13.12

11q12.3

Type of geneprotein-codingprotein-coding
Descriptioncalpain small subunit 1CANP small subunitcalcium-activated neutral proteinase small subunitcalcium-dependent protease small subunit 1calcium-dependent protease, small subunitcalpain 4, small subunit (30K)calpain regulatory subunitcalpain, small polmetastasis-associated protein MTA2MTA1-L1 proteinmetastasis -associated gene 1-like 1metastasis associated gene family, member 2metastasis-associated 1-like 1metastasis-associated protein 2p53 target protein in deacetylase complex
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000587718, ENST00000246533, 
ENST00000588815, ENST00000588780, 
ENST00000589146, ENST00000590874, 
Fusion gene scores* DoF score29 X 25 X 9=65254 X 4 X 3=48
# samples 314
** MAII scorelog2(31/6525*10)=-4.39563778107037
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPNS1 [Title/Abstract] AND MTA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAPNS1(36641254)-MTA2(62363809), # samples:1
Anticipated loss of major functional domain due to fusion event.CAPNS1-MTA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPNS1-MTA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPNS1-MTA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPNS1-MTA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPNS1-MTA2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CAPNS1-MTA2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CAPNS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MTA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5506-01ACAPNS1chr19

36641254

-MTA2chr11

62363809

-


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Fusion Gene ORF analysis for CAPNS1-MTA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000587718ENST00000278823CAPNS1chr19

36641254

-MTA2chr11

62363809

-
Frame-shiftENST00000587718ENST00000524902CAPNS1chr19

36641254

-MTA2chr11

62363809

-
Frame-shiftENST00000587718ENST00000527204CAPNS1chr19

36641254

-MTA2chr11

62363809

-
In-frameENST00000246533ENST00000278823CAPNS1chr19

36641254

-MTA2chr11

62363809

-
In-frameENST00000246533ENST00000524902CAPNS1chr19

36641254

-MTA2chr11

62363809

-
In-frameENST00000246533ENST00000527204CAPNS1chr19

36641254

-MTA2chr11

62363809

-
In-frameENST00000588815ENST00000278823CAPNS1chr19

36641254

-MTA2chr11

62363809

-
In-frameENST00000588815ENST00000524902CAPNS1chr19

36641254

-MTA2chr11

62363809

-
In-frameENST00000588815ENST00000527204CAPNS1chr19

36641254

-MTA2chr11

62363809

-
intron-3CDSENST00000588780ENST00000278823CAPNS1chr19

36641254

-MTA2chr11

62363809

-
intron-3CDSENST00000588780ENST00000524902CAPNS1chr19

36641254

-MTA2chr11

62363809

-
intron-3CDSENST00000588780ENST00000527204CAPNS1chr19

36641254

-MTA2chr11

62363809

-
intron-3CDSENST00000589146ENST00000278823CAPNS1chr19

36641254

-MTA2chr11

62363809

-
intron-3CDSENST00000589146ENST00000524902CAPNS1chr19

36641254

-MTA2chr11

62363809

-
intron-3CDSENST00000589146ENST00000527204CAPNS1chr19

36641254

-MTA2chr11

62363809

-
intron-3CDSENST00000590874ENST00000278823CAPNS1chr19

36641254

-MTA2chr11

62363809

-
intron-3CDSENST00000590874ENST00000524902CAPNS1chr19

36641254

-MTA2chr11

62363809

-
intron-3CDSENST00000590874ENST00000527204CAPNS1chr19

36641254

-MTA2chr11

62363809

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000246533CAPNS1chr1936641254-ENST00000278823MTA2chr1162363809-3629191818612967368
ENST00000246533CAPNS1chr1936641254-ENST00000524902MTA2chr1162363809-3628191818612967368
ENST00000246533CAPNS1chr1936641254-ENST00000527204MTA2chr1162363809-3001191818612967368
ENST00000588815CAPNS1chr1936641254-ENST00000278823MTA2chr1162363809-3182147114142520368
ENST00000588815CAPNS1chr1936641254-ENST00000524902MTA2chr1162363809-3181147114142520368
ENST00000588815CAPNS1chr1936641254-ENST00000527204MTA2chr1162363809-2554147114142520368

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000246533ENST00000278823CAPNS1chr1936641254-MTA2chr1162363809-0.0213156230.97868437
ENST00000246533ENST00000524902CAPNS1chr1936641254-MTA2chr1162363809-0.0211266630.9788734
ENST00000246533ENST00000527204CAPNS1chr1936641254-MTA2chr1162363809-0.0308647250.9691353
ENST00000588815ENST00000278823CAPNS1chr1936641254-MTA2chr1162363809-0.0185160880.98148394
ENST00000588815ENST00000524902CAPNS1chr1936641254-MTA2chr1162363809-0.0183607840.98163927
ENST00000588815ENST00000527204CAPNS1chr1936641254-MTA2chr1162363809-0.0219482350.9780517

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Fusion Genomic Features for CAPNS1-MTA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CAPNS1-MTA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:36641254/chr11:62363809)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000246533-1111108_119440269.0Calcium binding1
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000246533-1111152_163440269.0Calcium binding2
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000246533-1111182_193440269.0Calcium binding3
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000587718-1010108_119497323.0Calcium binding1
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000587718-1010152_163497323.0Calcium binding2
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000587718-1010182_193497323.0Calcium binding3
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000588815-1111108_119440269.0Calcium binding1
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000588815-1111152_163440269.0Calcium binding2
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000588815-1111182_193440269.0Calcium binding3
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000246533-111110_26440269.0Compositional biasNote=Poly-Gly
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000246533-11111_66440269.0Compositional biasNote=Gly-rich (hydrophobic)
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000246533-111135_56440269.0Compositional biasNote=Poly-Gly
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000246533-111178_83440269.0Compositional biasNote=Poly-Pro
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000587718-101010_26497323.0Compositional biasNote=Poly-Gly
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000587718-10101_66497323.0Compositional biasNote=Gly-rich (hydrophobic)
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000587718-101035_56497323.0Compositional biasNote=Poly-Gly
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000587718-101078_83497323.0Compositional biasNote=Poly-Pro
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000588815-111110_26440269.0Compositional biasNote=Poly-Gly
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000588815-11111_66440269.0Compositional biasNote=Gly-rich (hydrophobic)
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000588815-111135_56440269.0Compositional biasNote=Poly-Gly
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000588815-111178_83440269.0Compositional biasNote=Poly-Pro
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000246533-1111139_172440269.0DomainEF-hand 2
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000246533-1111169_204440269.0DomainEF-hand 3
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000246533-1111205_233440269.0DomainEF-hand 4
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000246533-1111234_268440269.0DomainEF-hand 5
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000246533-111191_125440269.0DomainEF-hand 1%3B atypical
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000587718-1010139_172497323.0DomainEF-hand 2
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000587718-1010169_204497323.0DomainEF-hand 3
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000587718-1010205_233497323.0DomainEF-hand 4
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000587718-1010234_268497323.0DomainEF-hand 5
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000587718-101091_125497323.0DomainEF-hand 1%3B atypical
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000588815-1111139_172440269.0DomainEF-hand 2
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000588815-1111169_204440269.0DomainEF-hand 3
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000588815-1111205_233440269.0DomainEF-hand 4
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000588815-1111234_268440269.0DomainEF-hand 5
HgeneCAPNS1chr19:36641254chr11:62363809ENST00000588815-111191_125440269.0DomainEF-hand 1%3B atypical
TgeneMTA2chr19:36641254chr11:62363809ENST00000278823918367_394319669.0Zinc fingerNote=GATA-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMTA2chr19:36641254chr11:62363809ENST00000278823918145_256319669.0DomainELM2
TgeneMTA2chr19:36641254chr11:62363809ENST000002788239181_144319669.0DomainBAH
TgeneMTA2chr19:36641254chr11:62363809ENST00000278823918263_315319669.0DomainSANT


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Fusion Gene Sequence for CAPNS1-MTA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12923_12923_1_CAPNS1-MTA2_CAPNS1_chr19_36641254_ENST00000246533_MTA2_chr11_62363809_ENST00000278823_length(transcript)=3629nt_BP=1918nt
TGCCATCCGGGCTGCTGCAGGCACTGGGAAAGGCAATCCAGCCTCAATCCTCGCCACAGACACGGGCGACTGTCCCCCAGCGTGTGAGTC
AAACCATACTCCAGGCCTCCAGGAGGTGTTTGTCGCGACAACACCTGCAGAGGGCCCGTGCGGAGTCCCTTAGTGAGCGGACCGAAAACC
GCCACCCTGGAAGGATATTGGCATGCCCTAGGGTGAAAATTCACACTACGACACTCGGGGGGTGGGTCCCCTCCGAGTTCTCGTCCGCGG
GTGCCTCCACCCAGACCTGAGGGGTGTCGGGAAGACCCCCGCCTACCGAGTCAGGGCGGGATTAAGACCTCCGGCGCTGGAAACGCGTAG
GGCGGGGCCCAGACCTGGATCCAGCTAGCCGGGCGGTGTGGGGTGCGCATGCGCAATGTCCGCTTCGGCTCTAGGACCGCGCGGGCGACA
GCAGGGCCGCGGTGCAGTGTCCGACCCGAGAGTTGCGGCCTGAGTCACCGGCCCCGCCCTCCGGAGCCGGACGCTGCGGGAGGCCCGGGA
GCGGCAGTGGAACCGACTCCCAGAACTCCGGACGTGTGCGGCGCAGTGAGTCGCAGCCATGTTCCTGGTTAACTCGTTCTTGAAGGGCGG
CGGCGGCGGCGGCGGGGGAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATCAGCGGGGCCGGGGGCGGCGGCGG
CGGCGGCGGCGGCGGCGGCGGTGGTGGAGGCGGCGGTGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCAGCGA
GGCGGCTGCGCAGTACAACCCGGAGCCCCCGCCCCCACGCACACATTACTCCAACATTGAGGCCAACGAGAGTGAGGAGGTCCGGCAGTT
CCGGAGACTCTTTGCCCAGCTGGCTGGAGATGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACGACA
CCCTGATCTGAAGACTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCCGTGATGGATAGCGACACCACAGGCAAGCTGGGCTT
TGAGGAATTCAAGTACTTGTGGAACAACATCAAAAGGTGGCAGGCCATATACAAACAGTTCGACACTGACCGATCAGGGACCATTTGCAG
TAGTGAACTCCCAGGTGCCTTTGAGGCAGCAGGGTTCCACCTGAATGAGCATCTCTATAACATGATCATCCGACGCTACTCAGATGAAAG
TGGGAACATGGATTTTGACAACTTCATCAGCTGCTTGGTCAGGCTGGACGCCATGTTCCGTGCCTTCAAATCTCTTGACAAAGATGGCAC
TGGACAAATCCAGGTGAACATCCAGGAGTGGCTGCAGCTGACTATGTATTCCTGAACTGGAGCCCCAGACCCGCCCCCTCACTGCCTTGC
TATAGGAGTCACCTGGAGCCTCGGTCTCTCCCAGGGCCGATCCTGTCTGCAGTCACATCTTTGTGGGGCCTGCTGACCCACAAGCTTTTG
TTCTCTCAGTACTTGTTACCCAGCTTCTCAACATCCAGGGCCCAATTTGCCCTGCCTGGAGTTCCCCCTGGCTCTAGGACACTCTAACAA
GCTCTGTCCACGGGTCTCCCCATTCCCACCAGGCCCTGCACACACCCACTCCGTAACCTCTCCCCTGTACCTGTGCCAAGCCTAGCACTT
GTGATGCCTCCATGCCCCGAGGGCCCTCTCTCAGTTCTGGGAGGATGACTCCAGTCCCTGCACGCCCTGGCACACCCTTCACGGTTGCTA
CCCAGGCGGCCAAGCTCCAGACCGTGCCAGACCCAGGTGCCCCAGTGCCTTTGTCTATATTCTGCTCCCAGCCTGCCAGGCCCAGGAGGA
AATAAACATGCCCCAGTTGCTGATCTCTAAAAGGTTGAAAGCTGCTGAAGCAGACAGCAAACTGAAACAGGTCTACATTCCCACCTACAC
TAAGCCAAACCCTAACCAGATCATTTCTGTGGGTTCAAAACCTGGCATGAATGGGGCTGGATTTCAGAAGGGCCTGACTTGTGAGAGTTG
CCACACCACACAGTCTGCTCAGTGGTATGCCTGGGGCCCACCTAACATGCAGTGCCGCCTCTGTGCTTCCTGTTGGATCTACTGGAAGAA
GTATGGGGGACTGAAGACCCCAACTCAGCTTGAGGGGGCCACTCGGGGCACCACGGAGCCACACTCAAGGGGTCATTTATCCAGACCTGA
AGCTCAAAGTCTCTCTCCTTACACAACCAGCGCCAACAGGGCCAAGCTACTGGCTAAGAACAGACAAACTTTCCTGCTTCAGACCACAAA
GCTGACCCGTCTTGCCAGACGCATGTGCAGGGACCTATTACAGCCAAGGAGGGCCGCCCGACGGCCTTATGCTCCTATCAATGCCAATGC
CATCAAAGCAGAGTGCTCCATTCGACTTCCTAAGGCCGCCAAGACTCCATTGAAGATTCACCCTCTGGTGCGGCTGCCCCTGGCAACTAT
CGTCAAAGATCTGGTGGCCCAGGCACCCCTGAAACCAAAAACACCTCGGGGTACCAAGACACCGATCAACAGAAACCAGCTGTCCCAGAA
CCGGGGACTGGGGGGCATTATGGTGAAACGGGCCTATGAGACTATGGCAGGGGCAGGGGTTCCTTTCTCTGCCAATGGAAGGCCTCTGGC
TTCAGGGATTCGTTCAAGCTCACAGCCAGCAGCCAAGCGTCAGAAACTAAACCCAGCTGATGCCCCCAATCCTGTGGTGTTTGTGGCCAC
AAAGGATACCAGGGCCCTACGGAAGGCTCTGACCCATCTGGAAATGCGGCGAGCTGCTCGCCGACCCAACTTGCCCCTGAAGGTGAAGCC
AACGCTGATTGCAGTGCGGCCCCCTGTCCCTCTACCTGCACCCTCACATCCTGCCAGCACCAATGAGCCTATTGTCCTGGAGGACTGAGC
ACCTGTGGGGAAGGGAGGTGGGCTGAGAGGTAGAGGGTGGATGCCCAGGGCACCCAAACCTCCCTTCCCTTTCGTGTCGAAGGGAGTGAG
GAGTGAATTAAGGAAGAGAGCAAGTGAGTGTGTGTCCCTGGAGGGGTTGGGCGCCCTCTGGTGTTACCACCTCGAGACTTGTCTCATGCC
TCCATGCTTGCCGATGGAGGACAGACTGCAGGAACTTGGCCCATGTGGGAACCTAGCCTGTTTTGGGGGGTAGGACCCACAGATGTCTTG
GACAGTTTTGGGGGGAGGGTTTTTTAATTTTTTAAAAATTTTGCCTCCCTTTGTGAAAGGGGATGGGGAGGGGAAGAGTAAACAGATAAC
AGGTGGTGGTACCTGGTTGGGGGAGGGGGGCGTGCACTGCCATGTCTTTTTTTTTTTTTTTTTTTTTTTTTTTCCTAATTGGGGGTTTCT
CTTTCTGTCCGGTGTCCGGACTTTCCTAATTGGAGTTTGAGGCCCCTAAGCTGGCATCAACCCCAGGCCACGCTCGCTCTTTCCTTCCCT
CCCCTCCCCCTCTGCCTTTTGTACGCCAGTTCTCAGAAATAAAGATCTTTTGTCCGTTTTTTTAACCTCGGATTCTGTAATTGGTTCTTA
TAGTAACAAATAAAAAGCTGTTTTCTTCA

>12923_12923_1_CAPNS1-MTA2_CAPNS1_chr19_36641254_ENST00000246533_MTA2_chr11_62363809_ENST00000278823_length(amino acids)=368AA_BP=19
MLPACQAQEEINMPQLLISKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMNGAGFQKGLTCESCHTTQSAQWYAWGPPNMQCRL
CASCWIYWKKYGGLKTPTQLEGATRGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAAR
RPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDLVAQAPLKPKTPRGTKTPINRNQLSQNRGLGGIMVKRAYETMAGAGV
PFSANGRPLASGIRSSSQPAAKRQKLNPADAPNPVVFVATKDTRALRKALTHLEMRRAARRPNLPLKVKPTLIAVRPPVPLPAPSHPAST
NEPIVLED

--------------------------------------------------------------
>12923_12923_2_CAPNS1-MTA2_CAPNS1_chr19_36641254_ENST00000246533_MTA2_chr11_62363809_ENST00000524902_length(transcript)=3628nt_BP=1918nt
TGCCATCCGGGCTGCTGCAGGCACTGGGAAAGGCAATCCAGCCTCAATCCTCGCCACAGACACGGGCGACTGTCCCCCAGCGTGTGAGTC
AAACCATACTCCAGGCCTCCAGGAGGTGTTTGTCGCGACAACACCTGCAGAGGGCCCGTGCGGAGTCCCTTAGTGAGCGGACCGAAAACC
GCCACCCTGGAAGGATATTGGCATGCCCTAGGGTGAAAATTCACACTACGACACTCGGGGGGTGGGTCCCCTCCGAGTTCTCGTCCGCGG
GTGCCTCCACCCAGACCTGAGGGGTGTCGGGAAGACCCCCGCCTACCGAGTCAGGGCGGGATTAAGACCTCCGGCGCTGGAAACGCGTAG
GGCGGGGCCCAGACCTGGATCCAGCTAGCCGGGCGGTGTGGGGTGCGCATGCGCAATGTCCGCTTCGGCTCTAGGACCGCGCGGGCGACA
GCAGGGCCGCGGTGCAGTGTCCGACCCGAGAGTTGCGGCCTGAGTCACCGGCCCCGCCCTCCGGAGCCGGACGCTGCGGGAGGCCCGGGA
GCGGCAGTGGAACCGACTCCCAGAACTCCGGACGTGTGCGGCGCAGTGAGTCGCAGCCATGTTCCTGGTTAACTCGTTCTTGAAGGGCGG
CGGCGGCGGCGGCGGGGGAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATCAGCGGGGCCGGGGGCGGCGGCGG
CGGCGGCGGCGGCGGCGGCGGTGGTGGAGGCGGCGGTGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCAGCGA
GGCGGCTGCGCAGTACAACCCGGAGCCCCCGCCCCCACGCACACATTACTCCAACATTGAGGCCAACGAGAGTGAGGAGGTCCGGCAGTT
CCGGAGACTCTTTGCCCAGCTGGCTGGAGATGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACGACA
CCCTGATCTGAAGACTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCCGTGATGGATAGCGACACCACAGGCAAGCTGGGCTT
TGAGGAATTCAAGTACTTGTGGAACAACATCAAAAGGTGGCAGGCCATATACAAACAGTTCGACACTGACCGATCAGGGACCATTTGCAG
TAGTGAACTCCCAGGTGCCTTTGAGGCAGCAGGGTTCCACCTGAATGAGCATCTCTATAACATGATCATCCGACGCTACTCAGATGAAAG
TGGGAACATGGATTTTGACAACTTCATCAGCTGCTTGGTCAGGCTGGACGCCATGTTCCGTGCCTTCAAATCTCTTGACAAAGATGGCAC
TGGACAAATCCAGGTGAACATCCAGGAGTGGCTGCAGCTGACTATGTATTCCTGAACTGGAGCCCCAGACCCGCCCCCTCACTGCCTTGC
TATAGGAGTCACCTGGAGCCTCGGTCTCTCCCAGGGCCGATCCTGTCTGCAGTCACATCTTTGTGGGGCCTGCTGACCCACAAGCTTTTG
TTCTCTCAGTACTTGTTACCCAGCTTCTCAACATCCAGGGCCCAATTTGCCCTGCCTGGAGTTCCCCCTGGCTCTAGGACACTCTAACAA
GCTCTGTCCACGGGTCTCCCCATTCCCACCAGGCCCTGCACACACCCACTCCGTAACCTCTCCCCTGTACCTGTGCCAAGCCTAGCACTT
GTGATGCCTCCATGCCCCGAGGGCCCTCTCTCAGTTCTGGGAGGATGACTCCAGTCCCTGCACGCCCTGGCACACCCTTCACGGTTGCTA
CCCAGGCGGCCAAGCTCCAGACCGTGCCAGACCCAGGTGCCCCAGTGCCTTTGTCTATATTCTGCTCCCAGCCTGCCAGGCCCAGGAGGA
AATAAACATGCCCCAGTTGCTGATCTCTAAAAGGTTGAAAGCTGCTGAAGCAGACAGCAAACTGAAACAGGTCTACATTCCCACCTACAC
TAAGCCAAACCCTAACCAGATCATTTCTGTGGGTTCAAAACCTGGCATGAATGGGGCTGGATTTCAGAAGGGCCTGACTTGTGAGAGTTG
CCACACCACACAGTCTGCTCAGTGGTATGCCTGGGGCCCACCTAACATGCAGTGCCGCCTCTGTGCTTCCTGTTGGATCTACTGGAAGAA
GTATGGGGGACTGAAGACCCCAACTCAGCTTGAGGGGGCCACTCGGGGCACCACGGAGCCACACTCAAGGGGTCATTTATCCAGACCTGA
AGCTCAAAGTCTCTCTCCTTACACAACCAGCGCCAACAGGGCCAAGCTACTGGCTAAGAACAGACAAACTTTCCTGCTTCAGACCACAAA
GCTGACCCGTCTTGCCAGACGCATGTGCAGGGACCTATTACAGCCAAGGAGGGCCGCCCGACGGCCTTATGCTCCTATCAATGCCAATGC
CATCAAAGCAGAGTGCTCCATTCGACTTCCTAAGGCCGCCAAGACTCCATTGAAGATTCACCCTCTGGTGCGGCTGCCCCTGGCAACTAT
CGTCAAAGATCTGGTGGCCCAGGCACCCCTGAAACCAAAAACACCTCGGGGTACCAAGACACCGATCAACAGAAACCAGCTGTCCCAGAA
CCGGGGACTGGGGGGCATTATGGTGAAACGGGCCTATGAGACTATGGCAGGGGCAGGGGTTCCTTTCTCTGCCAATGGAAGGCCTCTGGC
TTCAGGGATTCGTTCAAGCTCACAGCCAGCAGCCAAGCGTCAGAAACTAAACCCAGCTGATGCCCCCAATCCTGTGGTGTTTGTGGCCAC
AAAGGATACCAGGGCCCTACGGAAGGCTCTGACCCATCTGGAAATGCGGCGAGCTGCTCGCCGACCCAACTTGCCCCTGAAGGTGAAGCC
AACGCTGATTGCAGTGCGGCCCCCTGTCCCTCTACCTGCACCCTCACATCCTGCCAGCACCAATGAGCCTATTGTCCTGGAGGACTGAGC
ACCTGTGGGGAAGGGAGGTGGGCTGAGAGGTAGAGGGTGGATGCCCAGGGCACCCAAACCTCCCTTCCCTTTCGTGTCGAAGGGAGTGAG
GAGTGAATTAAGGAAGAGAGCAAGTGAGTGTGTGTCCCTGGAGGGGTTGGGCGCCCTCTGGTGTTACCACCTCGAGACTTGTCTCATGCC
TCCATGCTTGCCGATGGAGGACAGACTGCAGGAACTTGGCCCATGTGGGAACCTAGCCTGTTTTGGGGGGTAGGACCCACAGATGTCTTG
GACAGTTTTGGGGGGAGGGTTTTTTAATTTTTTAAAAATTTTGCCTCCCTTTGTGAAAGGGGATGGGGAGGGGAAGAGTAAACAGATAAC
AGGTGGTGGTACCTGGTTGGGGGAGGGGGGCGTGCACTGCCATGTCTTTTTTTTTTTTTTTTTTTTTTTTTTTCCTAATTGGGGGTTTCT
CTTTCTGTCCGGTGTCCGGACTTTCCTAATTGGAGTTTGAGGCCCCTAAGCTGGCATCAACCCCAGGCCACGCTCGCTCTTTCCTTCCCT
CCCCTCCCCCTCTGCCTTTTGTACGCCAGTTCTCAGAAATAAAGATCTTTTGTCCGTTTTTTTAACCTCGGATTCTGTAATTGGTTCTTA
TAGTAACAAATAAAAAGCTGTTTTCTTC

>12923_12923_2_CAPNS1-MTA2_CAPNS1_chr19_36641254_ENST00000246533_MTA2_chr11_62363809_ENST00000524902_length(amino acids)=368AA_BP=19
MLPACQAQEEINMPQLLISKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMNGAGFQKGLTCESCHTTQSAQWYAWGPPNMQCRL
CASCWIYWKKYGGLKTPTQLEGATRGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAAR
RPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDLVAQAPLKPKTPRGTKTPINRNQLSQNRGLGGIMVKRAYETMAGAGV
PFSANGRPLASGIRSSSQPAAKRQKLNPADAPNPVVFVATKDTRALRKALTHLEMRRAARRPNLPLKVKPTLIAVRPPVPLPAPSHPAST
NEPIVLED

--------------------------------------------------------------
>12923_12923_3_CAPNS1-MTA2_CAPNS1_chr19_36641254_ENST00000246533_MTA2_chr11_62363809_ENST00000527204_length(transcript)=3001nt_BP=1918nt
TGCCATCCGGGCTGCTGCAGGCACTGGGAAAGGCAATCCAGCCTCAATCCTCGCCACAGACACGGGCGACTGTCCCCCAGCGTGTGAGTC
AAACCATACTCCAGGCCTCCAGGAGGTGTTTGTCGCGACAACACCTGCAGAGGGCCCGTGCGGAGTCCCTTAGTGAGCGGACCGAAAACC
GCCACCCTGGAAGGATATTGGCATGCCCTAGGGTGAAAATTCACACTACGACACTCGGGGGGTGGGTCCCCTCCGAGTTCTCGTCCGCGG
GTGCCTCCACCCAGACCTGAGGGGTGTCGGGAAGACCCCCGCCTACCGAGTCAGGGCGGGATTAAGACCTCCGGCGCTGGAAACGCGTAG
GGCGGGGCCCAGACCTGGATCCAGCTAGCCGGGCGGTGTGGGGTGCGCATGCGCAATGTCCGCTTCGGCTCTAGGACCGCGCGGGCGACA
GCAGGGCCGCGGTGCAGTGTCCGACCCGAGAGTTGCGGCCTGAGTCACCGGCCCCGCCCTCCGGAGCCGGACGCTGCGGGAGGCCCGGGA
GCGGCAGTGGAACCGACTCCCAGAACTCCGGACGTGTGCGGCGCAGTGAGTCGCAGCCATGTTCCTGGTTAACTCGTTCTTGAAGGGCGG
CGGCGGCGGCGGCGGGGGAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATCAGCGGGGCCGGGGGCGGCGGCGG
CGGCGGCGGCGGCGGCGGCGGTGGTGGAGGCGGCGGTGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCAGCGA
GGCGGCTGCGCAGTACAACCCGGAGCCCCCGCCCCCACGCACACATTACTCCAACATTGAGGCCAACGAGAGTGAGGAGGTCCGGCAGTT
CCGGAGACTCTTTGCCCAGCTGGCTGGAGATGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACGACA
CCCTGATCTGAAGACTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCCGTGATGGATAGCGACACCACAGGCAAGCTGGGCTT
TGAGGAATTCAAGTACTTGTGGAACAACATCAAAAGGTGGCAGGCCATATACAAACAGTTCGACACTGACCGATCAGGGACCATTTGCAG
TAGTGAACTCCCAGGTGCCTTTGAGGCAGCAGGGTTCCACCTGAATGAGCATCTCTATAACATGATCATCCGACGCTACTCAGATGAAAG
TGGGAACATGGATTTTGACAACTTCATCAGCTGCTTGGTCAGGCTGGACGCCATGTTCCGTGCCTTCAAATCTCTTGACAAAGATGGCAC
TGGACAAATCCAGGTGAACATCCAGGAGTGGCTGCAGCTGACTATGTATTCCTGAACTGGAGCCCCAGACCCGCCCCCTCACTGCCTTGC
TATAGGAGTCACCTGGAGCCTCGGTCTCTCCCAGGGCCGATCCTGTCTGCAGTCACATCTTTGTGGGGCCTGCTGACCCACAAGCTTTTG
TTCTCTCAGTACTTGTTACCCAGCTTCTCAACATCCAGGGCCCAATTTGCCCTGCCTGGAGTTCCCCCTGGCTCTAGGACACTCTAACAA
GCTCTGTCCACGGGTCTCCCCATTCCCACCAGGCCCTGCACACACCCACTCCGTAACCTCTCCCCTGTACCTGTGCCAAGCCTAGCACTT
GTGATGCCTCCATGCCCCGAGGGCCCTCTCTCAGTTCTGGGAGGATGACTCCAGTCCCTGCACGCCCTGGCACACCCTTCACGGTTGCTA
CCCAGGCGGCCAAGCTCCAGACCGTGCCAGACCCAGGTGCCCCAGTGCCTTTGTCTATATTCTGCTCCCAGCCTGCCAGGCCCAGGAGGA
AATAAACATGCCCCAGTTGCTGATCTCTAAAAGGTTGAAAGCTGCTGAAGCAGACAGCAAACTGAAACAGGTCTACATTCCCACCTACAC
TAAGCCAAACCCTAACCAGATCATTTCTGTGGGTTCAAAACCTGGCATGAATGGGGCTGGATTTCAGAAGGGCCTGACTTGTGAGAGTTG
CCACACCACACAGTCTGCTCAGTGGTATGCCTGGGGCCCACCTAACATGCAGTGCCGCCTCTGTGCTTCCTGTTGGATCTACTGGAAGAA
GTATGGGGGACTGAAGACCCCAACTCAGCTTGAGGGGGCCACTCGGGGCACCACGGAGCCACACTCAAGGGGTCATTTATCCAGACCTGA
AGCTCAAAGTCTCTCTCCTTACACAACCAGCGCCAACAGGGCCAAGCTACTGGCTAAGAACAGACAAACTTTCCTGCTTCAGACCACAAA
GCTGACCCGTCTTGCCAGACGCATGTGCAGGGACCTATTACAGCCAAGGAGGGCCGCCCGACGGCCTTATGCTCCTATCAATGCCAATGC
CATCAAAGCAGAGTGCTCCATTCGACTTCCTAAGGCCGCCAAGACTCCATTGAAGATTCACCCTCTGGTGCGGCTGCCCCTGGCAACTAT
CGTCAAAGATCTGGTGGCCCAGGCACCCCTGAAACCAAAAACACCTCGGGGTACCAAGACACCGATCAACAGAAACCAGCTGTCCCAGAA
CCGGGGACTGGGGGGCATTATGGTGAAACGGGCCTATGAGACTATGGCAGGGGCAGGGGTTCCTTTCTCTGCCAATGGAAGGCCTCTGGC
TTCAGGGATTCGTTCAAGCTCACAGCCAGCAGCCAAGCGTCAGAAACTAAACCCAGCTGATGCCCCCAATCCTGTGGTGTTTGTGGCCAC
AAAGGATACCAGGGCCCTACGGAAGGCTCTGACCCATCTGGAAATGCGGCGAGCTGCTCGCCGACCCAACTTGCCCCTGAAGGTGAAGCC
AACGCTGATTGCAGTGCGGCCCCCTGTCCCTCTACCTGCACCCTCACATCCTGCCAGCACCAATGAGCCTATTGTCCTGGAGGACTGAGC
ACCTGTGGGGAAGGGAGGTGGGCTGAGAGGT

>12923_12923_3_CAPNS1-MTA2_CAPNS1_chr19_36641254_ENST00000246533_MTA2_chr11_62363809_ENST00000527204_length(amino acids)=368AA_BP=19
MLPACQAQEEINMPQLLISKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMNGAGFQKGLTCESCHTTQSAQWYAWGPPNMQCRL
CASCWIYWKKYGGLKTPTQLEGATRGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAAR
RPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDLVAQAPLKPKTPRGTKTPINRNQLSQNRGLGGIMVKRAYETMAGAGV
PFSANGRPLASGIRSSSQPAAKRQKLNPADAPNPVVFVATKDTRALRKALTHLEMRRAARRPNLPLKVKPTLIAVRPPVPLPAPSHPAST
NEPIVLED

--------------------------------------------------------------
>12923_12923_4_CAPNS1-MTA2_CAPNS1_chr19_36641254_ENST00000588815_MTA2_chr11_62363809_ENST00000278823_length(transcript)=3182nt_BP=1471nt
CCGACTCCCAGAACTCCGGACGTGTGCGGCGGTAAGCGCCCGGCCCGTACCCCCTCCGCACCCCGCAACTCCGACTTTGGCGGCCCCCAG
ACCCGGCGAAACCGTGAAGTCTCGGCCTCAGGAGCCCCCCAGATCCATGTGAGTCGCAGCCATGTTCCTGGTTAACTCGTTCTTGAAGGG
CGGCGGCGGCGGCGGCGGGGGAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATCAGCGGGGCCGGGGGCGGCGG
CGGCGGCGGCGGCGGCGGCGGCGGTGGTGGAGGCGGCGGTGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCAG
CGAGGCGGCTGCGCAGTACAACCCGGAGCCCCCGCCCCCACGCACACATTACTCCAACATTGAGGCCAACGAGAGTGAGGAGGTCCGGCA
GTTCCGGAGACTCTTTGCCCAGCTGGCTGGAGATGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACG
ACACCCTGATCTGAAGACTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCCGTGATGGATAGCGACACCACAGGCAAGCTGGG
CTTTGAGGAATTCAAGTACTTGTGGAACAACATCAAAAGGTGGCAGGCCATATACAAACAGTTCGACACTGACCGATCAGGGACCATTTG
CAGTAGTGAACTCCCAGGTGCCTTTGAGGCAGCAGGGTTCCACCTGAATGAGCATCTCTATAACATGATCATCCGACGCTACTCAGATGA
AAGTGGGAACATGGATTTTGACAACTTCATCAGCTGCTTGGTCAGGCTGGACGCCATGTTCCGTGCCTTCAAATCTCTTGACAAAGATGG
CACTGGACAAATCCAGGTGAACATCCAGGAGTGGCTGCAGCTGACTATGTATTCCTGAACTGGAGCCCCAGACCCGCCCCCTCACTGCCT
TGCTATAGGAGTCACCTGGAGCCTCGGTCTCTCCCAGGGCCGATCCTGTCTGCAGTCACATCTTTGTGGGGCCTGCTGACCCACAAGCTT
TTGTTCTCTCAGTACTTGTTACCCAGCTTCTCAACATCCAGGGCCCAATTTGCCCTGCCTGGAGTTCCCCCTGGCTCTAGGACACTCTAA
CAAGCTCTGTCCACGGGTCTCCCCATTCCCACCAGGCCCTGCACACACCCACTCCGTAACCTCTCCCCTGTACCTGTGCCAAGCCTAGCA
CTTGTGATGCCTCCATGCCCCGAGGGCCCTCTCTCAGTTCTGGGAGGATGACTCCAGTCCCTGCACGCCCTGGCACACCCTTCACGGTTG
CTACCCAGGCGGCCAAGCTCCAGACCGTGCCAGACCCAGGTGCCCCAGTGCCTTTGTCTATATTCTGCTCCCAGCCTGCCAGGCCCAGGA
GGAAATAAACATGCCCCAGTTGCTGATCTCTAAAAGGTTGAAAGCTGCTGAAGCAGACAGCAAACTGAAACAGGTCTACATTCCCACCTA
CACTAAGCCAAACCCTAACCAGATCATTTCTGTGGGTTCAAAACCTGGCATGAATGGGGCTGGATTTCAGAAGGGCCTGACTTGTGAGAG
TTGCCACACCACACAGTCTGCTCAGTGGTATGCCTGGGGCCCACCTAACATGCAGTGCCGCCTCTGTGCTTCCTGTTGGATCTACTGGAA
GAAGTATGGGGGACTGAAGACCCCAACTCAGCTTGAGGGGGCCACTCGGGGCACCACGGAGCCACACTCAAGGGGTCATTTATCCAGACC
TGAAGCTCAAAGTCTCTCTCCTTACACAACCAGCGCCAACAGGGCCAAGCTACTGGCTAAGAACAGACAAACTTTCCTGCTTCAGACCAC
AAAGCTGACCCGTCTTGCCAGACGCATGTGCAGGGACCTATTACAGCCAAGGAGGGCCGCCCGACGGCCTTATGCTCCTATCAATGCCAA
TGCCATCAAAGCAGAGTGCTCCATTCGACTTCCTAAGGCCGCCAAGACTCCATTGAAGATTCACCCTCTGGTGCGGCTGCCCCTGGCAAC
TATCGTCAAAGATCTGGTGGCCCAGGCACCCCTGAAACCAAAAACACCTCGGGGTACCAAGACACCGATCAACAGAAACCAGCTGTCCCA
GAACCGGGGACTGGGGGGCATTATGGTGAAACGGGCCTATGAGACTATGGCAGGGGCAGGGGTTCCTTTCTCTGCCAATGGAAGGCCTCT
GGCTTCAGGGATTCGTTCAAGCTCACAGCCAGCAGCCAAGCGTCAGAAACTAAACCCAGCTGATGCCCCCAATCCTGTGGTGTTTGTGGC
CACAAAGGATACCAGGGCCCTACGGAAGGCTCTGACCCATCTGGAAATGCGGCGAGCTGCTCGCCGACCCAACTTGCCCCTGAAGGTGAA
GCCAACGCTGATTGCAGTGCGGCCCCCTGTCCCTCTACCTGCACCCTCACATCCTGCCAGCACCAATGAGCCTATTGTCCTGGAGGACTG
AGCACCTGTGGGGAAGGGAGGTGGGCTGAGAGGTAGAGGGTGGATGCCCAGGGCACCCAAACCTCCCTTCCCTTTCGTGTCGAAGGGAGT
GAGGAGTGAATTAAGGAAGAGAGCAAGTGAGTGTGTGTCCCTGGAGGGGTTGGGCGCCCTCTGGTGTTACCACCTCGAGACTTGTCTCAT
GCCTCCATGCTTGCCGATGGAGGACAGACTGCAGGAACTTGGCCCATGTGGGAACCTAGCCTGTTTTGGGGGGTAGGACCCACAGATGTC
TTGGACAGTTTTGGGGGGAGGGTTTTTTAATTTTTTAAAAATTTTGCCTCCCTTTGTGAAAGGGGATGGGGAGGGGAAGAGTAAACAGAT
AACAGGTGGTGGTACCTGGTTGGGGGAGGGGGGCGTGCACTGCCATGTCTTTTTTTTTTTTTTTTTTTTTTTTTTTCCTAATTGGGGGTT
TCTCTTTCTGTCCGGTGTCCGGACTTTCCTAATTGGAGTTTGAGGCCCCTAAGCTGGCATCAACCCCAGGCCACGCTCGCTCTTTCCTTC
CCTCCCCTCCCCCTCTGCCTTTTGTACGCCAGTTCTCAGAAATAAAGATCTTTTGTCCGTTTTTTTAACCTCGGATTCTGTAATTGGTTC
TTATAGTAACAAATAAAAAGCTGTTTTCTTCA

>12923_12923_4_CAPNS1-MTA2_CAPNS1_chr19_36641254_ENST00000588815_MTA2_chr11_62363809_ENST00000278823_length(amino acids)=368AA_BP=19
MLPACQAQEEINMPQLLISKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMNGAGFQKGLTCESCHTTQSAQWYAWGPPNMQCRL
CASCWIYWKKYGGLKTPTQLEGATRGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAAR
RPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDLVAQAPLKPKTPRGTKTPINRNQLSQNRGLGGIMVKRAYETMAGAGV
PFSANGRPLASGIRSSSQPAAKRQKLNPADAPNPVVFVATKDTRALRKALTHLEMRRAARRPNLPLKVKPTLIAVRPPVPLPAPSHPAST
NEPIVLED

--------------------------------------------------------------
>12923_12923_5_CAPNS1-MTA2_CAPNS1_chr19_36641254_ENST00000588815_MTA2_chr11_62363809_ENST00000524902_length(transcript)=3181nt_BP=1471nt
CCGACTCCCAGAACTCCGGACGTGTGCGGCGGTAAGCGCCCGGCCCGTACCCCCTCCGCACCCCGCAACTCCGACTTTGGCGGCCCCCAG
ACCCGGCGAAACCGTGAAGTCTCGGCCTCAGGAGCCCCCCAGATCCATGTGAGTCGCAGCCATGTTCCTGGTTAACTCGTTCTTGAAGGG
CGGCGGCGGCGGCGGCGGGGGAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATCAGCGGGGCCGGGGGCGGCGG
CGGCGGCGGCGGCGGCGGCGGCGGTGGTGGAGGCGGCGGTGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCAG
CGAGGCGGCTGCGCAGTACAACCCGGAGCCCCCGCCCCCACGCACACATTACTCCAACATTGAGGCCAACGAGAGTGAGGAGGTCCGGCA
GTTCCGGAGACTCTTTGCCCAGCTGGCTGGAGATGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACG
ACACCCTGATCTGAAGACTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCCGTGATGGATAGCGACACCACAGGCAAGCTGGG
CTTTGAGGAATTCAAGTACTTGTGGAACAACATCAAAAGGTGGCAGGCCATATACAAACAGTTCGACACTGACCGATCAGGGACCATTTG
CAGTAGTGAACTCCCAGGTGCCTTTGAGGCAGCAGGGTTCCACCTGAATGAGCATCTCTATAACATGATCATCCGACGCTACTCAGATGA
AAGTGGGAACATGGATTTTGACAACTTCATCAGCTGCTTGGTCAGGCTGGACGCCATGTTCCGTGCCTTCAAATCTCTTGACAAAGATGG
CACTGGACAAATCCAGGTGAACATCCAGGAGTGGCTGCAGCTGACTATGTATTCCTGAACTGGAGCCCCAGACCCGCCCCCTCACTGCCT
TGCTATAGGAGTCACCTGGAGCCTCGGTCTCTCCCAGGGCCGATCCTGTCTGCAGTCACATCTTTGTGGGGCCTGCTGACCCACAAGCTT
TTGTTCTCTCAGTACTTGTTACCCAGCTTCTCAACATCCAGGGCCCAATTTGCCCTGCCTGGAGTTCCCCCTGGCTCTAGGACACTCTAA
CAAGCTCTGTCCACGGGTCTCCCCATTCCCACCAGGCCCTGCACACACCCACTCCGTAACCTCTCCCCTGTACCTGTGCCAAGCCTAGCA
CTTGTGATGCCTCCATGCCCCGAGGGCCCTCTCTCAGTTCTGGGAGGATGACTCCAGTCCCTGCACGCCCTGGCACACCCTTCACGGTTG
CTACCCAGGCGGCCAAGCTCCAGACCGTGCCAGACCCAGGTGCCCCAGTGCCTTTGTCTATATTCTGCTCCCAGCCTGCCAGGCCCAGGA
GGAAATAAACATGCCCCAGTTGCTGATCTCTAAAAGGTTGAAAGCTGCTGAAGCAGACAGCAAACTGAAACAGGTCTACATTCCCACCTA
CACTAAGCCAAACCCTAACCAGATCATTTCTGTGGGTTCAAAACCTGGCATGAATGGGGCTGGATTTCAGAAGGGCCTGACTTGTGAGAG
TTGCCACACCACACAGTCTGCTCAGTGGTATGCCTGGGGCCCACCTAACATGCAGTGCCGCCTCTGTGCTTCCTGTTGGATCTACTGGAA
GAAGTATGGGGGACTGAAGACCCCAACTCAGCTTGAGGGGGCCACTCGGGGCACCACGGAGCCACACTCAAGGGGTCATTTATCCAGACC
TGAAGCTCAAAGTCTCTCTCCTTACACAACCAGCGCCAACAGGGCCAAGCTACTGGCTAAGAACAGACAAACTTTCCTGCTTCAGACCAC
AAAGCTGACCCGTCTTGCCAGACGCATGTGCAGGGACCTATTACAGCCAAGGAGGGCCGCCCGACGGCCTTATGCTCCTATCAATGCCAA
TGCCATCAAAGCAGAGTGCTCCATTCGACTTCCTAAGGCCGCCAAGACTCCATTGAAGATTCACCCTCTGGTGCGGCTGCCCCTGGCAAC
TATCGTCAAAGATCTGGTGGCCCAGGCACCCCTGAAACCAAAAACACCTCGGGGTACCAAGACACCGATCAACAGAAACCAGCTGTCCCA
GAACCGGGGACTGGGGGGCATTATGGTGAAACGGGCCTATGAGACTATGGCAGGGGCAGGGGTTCCTTTCTCTGCCAATGGAAGGCCTCT
GGCTTCAGGGATTCGTTCAAGCTCACAGCCAGCAGCCAAGCGTCAGAAACTAAACCCAGCTGATGCCCCCAATCCTGTGGTGTTTGTGGC
CACAAAGGATACCAGGGCCCTACGGAAGGCTCTGACCCATCTGGAAATGCGGCGAGCTGCTCGCCGACCCAACTTGCCCCTGAAGGTGAA
GCCAACGCTGATTGCAGTGCGGCCCCCTGTCCCTCTACCTGCACCCTCACATCCTGCCAGCACCAATGAGCCTATTGTCCTGGAGGACTG
AGCACCTGTGGGGAAGGGAGGTGGGCTGAGAGGTAGAGGGTGGATGCCCAGGGCACCCAAACCTCCCTTCCCTTTCGTGTCGAAGGGAGT
GAGGAGTGAATTAAGGAAGAGAGCAAGTGAGTGTGTGTCCCTGGAGGGGTTGGGCGCCCTCTGGTGTTACCACCTCGAGACTTGTCTCAT
GCCTCCATGCTTGCCGATGGAGGACAGACTGCAGGAACTTGGCCCATGTGGGAACCTAGCCTGTTTTGGGGGGTAGGACCCACAGATGTC
TTGGACAGTTTTGGGGGGAGGGTTTTTTAATTTTTTAAAAATTTTGCCTCCCTTTGTGAAAGGGGATGGGGAGGGGAAGAGTAAACAGAT
AACAGGTGGTGGTACCTGGTTGGGGGAGGGGGGCGTGCACTGCCATGTCTTTTTTTTTTTTTTTTTTTTTTTTTTTCCTAATTGGGGGTT
TCTCTTTCTGTCCGGTGTCCGGACTTTCCTAATTGGAGTTTGAGGCCCCTAAGCTGGCATCAACCCCAGGCCACGCTCGCTCTTTCCTTC
CCTCCCCTCCCCCTCTGCCTTTTGTACGCCAGTTCTCAGAAATAAAGATCTTTTGTCCGTTTTTTTAACCTCGGATTCTGTAATTGGTTC
TTATAGTAACAAATAAAAAGCTGTTTTCTTC

>12923_12923_5_CAPNS1-MTA2_CAPNS1_chr19_36641254_ENST00000588815_MTA2_chr11_62363809_ENST00000524902_length(amino acids)=368AA_BP=19
MLPACQAQEEINMPQLLISKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMNGAGFQKGLTCESCHTTQSAQWYAWGPPNMQCRL
CASCWIYWKKYGGLKTPTQLEGATRGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAAR
RPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDLVAQAPLKPKTPRGTKTPINRNQLSQNRGLGGIMVKRAYETMAGAGV
PFSANGRPLASGIRSSSQPAAKRQKLNPADAPNPVVFVATKDTRALRKALTHLEMRRAARRPNLPLKVKPTLIAVRPPVPLPAPSHPAST
NEPIVLED

--------------------------------------------------------------
>12923_12923_6_CAPNS1-MTA2_CAPNS1_chr19_36641254_ENST00000588815_MTA2_chr11_62363809_ENST00000527204_length(transcript)=2554nt_BP=1471nt
CCGACTCCCAGAACTCCGGACGTGTGCGGCGGTAAGCGCCCGGCCCGTACCCCCTCCGCACCCCGCAACTCCGACTTTGGCGGCCCCCAG
ACCCGGCGAAACCGTGAAGTCTCGGCCTCAGGAGCCCCCCAGATCCATGTGAGTCGCAGCCATGTTCCTGGTTAACTCGTTCTTGAAGGG
CGGCGGCGGCGGCGGCGGGGGAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATCAGCGGGGCCGGGGGCGGCGG
CGGCGGCGGCGGCGGCGGCGGCGGTGGTGGAGGCGGCGGTGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCAG
CGAGGCGGCTGCGCAGTACAACCCGGAGCCCCCGCCCCCACGCACACATTACTCCAACATTGAGGCCAACGAGAGTGAGGAGGTCCGGCA
GTTCCGGAGACTCTTTGCCCAGCTGGCTGGAGATGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACG
ACACCCTGATCTGAAGACTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCCGTGATGGATAGCGACACCACAGGCAAGCTGGG
CTTTGAGGAATTCAAGTACTTGTGGAACAACATCAAAAGGTGGCAGGCCATATACAAACAGTTCGACACTGACCGATCAGGGACCATTTG
CAGTAGTGAACTCCCAGGTGCCTTTGAGGCAGCAGGGTTCCACCTGAATGAGCATCTCTATAACATGATCATCCGACGCTACTCAGATGA
AAGTGGGAACATGGATTTTGACAACTTCATCAGCTGCTTGGTCAGGCTGGACGCCATGTTCCGTGCCTTCAAATCTCTTGACAAAGATGG
CACTGGACAAATCCAGGTGAACATCCAGGAGTGGCTGCAGCTGACTATGTATTCCTGAACTGGAGCCCCAGACCCGCCCCCTCACTGCCT
TGCTATAGGAGTCACCTGGAGCCTCGGTCTCTCCCAGGGCCGATCCTGTCTGCAGTCACATCTTTGTGGGGCCTGCTGACCCACAAGCTT
TTGTTCTCTCAGTACTTGTTACCCAGCTTCTCAACATCCAGGGCCCAATTTGCCCTGCCTGGAGTTCCCCCTGGCTCTAGGACACTCTAA
CAAGCTCTGTCCACGGGTCTCCCCATTCCCACCAGGCCCTGCACACACCCACTCCGTAACCTCTCCCCTGTACCTGTGCCAAGCCTAGCA
CTTGTGATGCCTCCATGCCCCGAGGGCCCTCTCTCAGTTCTGGGAGGATGACTCCAGTCCCTGCACGCCCTGGCACACCCTTCACGGTTG
CTACCCAGGCGGCCAAGCTCCAGACCGTGCCAGACCCAGGTGCCCCAGTGCCTTTGTCTATATTCTGCTCCCAGCCTGCCAGGCCCAGGA
GGAAATAAACATGCCCCAGTTGCTGATCTCTAAAAGGTTGAAAGCTGCTGAAGCAGACAGCAAACTGAAACAGGTCTACATTCCCACCTA
CACTAAGCCAAACCCTAACCAGATCATTTCTGTGGGTTCAAAACCTGGCATGAATGGGGCTGGATTTCAGAAGGGCCTGACTTGTGAGAG
TTGCCACACCACACAGTCTGCTCAGTGGTATGCCTGGGGCCCACCTAACATGCAGTGCCGCCTCTGTGCTTCCTGTTGGATCTACTGGAA
GAAGTATGGGGGACTGAAGACCCCAACTCAGCTTGAGGGGGCCACTCGGGGCACCACGGAGCCACACTCAAGGGGTCATTTATCCAGACC
TGAAGCTCAAAGTCTCTCTCCTTACACAACCAGCGCCAACAGGGCCAAGCTACTGGCTAAGAACAGACAAACTTTCCTGCTTCAGACCAC
AAAGCTGACCCGTCTTGCCAGACGCATGTGCAGGGACCTATTACAGCCAAGGAGGGCCGCCCGACGGCCTTATGCTCCTATCAATGCCAA
TGCCATCAAAGCAGAGTGCTCCATTCGACTTCCTAAGGCCGCCAAGACTCCATTGAAGATTCACCCTCTGGTGCGGCTGCCCCTGGCAAC
TATCGTCAAAGATCTGGTGGCCCAGGCACCCCTGAAACCAAAAACACCTCGGGGTACCAAGACACCGATCAACAGAAACCAGCTGTCCCA
GAACCGGGGACTGGGGGGCATTATGGTGAAACGGGCCTATGAGACTATGGCAGGGGCAGGGGTTCCTTTCTCTGCCAATGGAAGGCCTCT
GGCTTCAGGGATTCGTTCAAGCTCACAGCCAGCAGCCAAGCGTCAGAAACTAAACCCAGCTGATGCCCCCAATCCTGTGGTGTTTGTGGC
CACAAAGGATACCAGGGCCCTACGGAAGGCTCTGACCCATCTGGAAATGCGGCGAGCTGCTCGCCGACCCAACTTGCCCCTGAAGGTGAA
GCCAACGCTGATTGCAGTGCGGCCCCCTGTCCCTCTACCTGCACCCTCACATCCTGCCAGCACCAATGAGCCTATTGTCCTGGAGGACTG
AGCACCTGTGGGGAAGGGAGGTGGGCTGAGAGGT

>12923_12923_6_CAPNS1-MTA2_CAPNS1_chr19_36641254_ENST00000588815_MTA2_chr11_62363809_ENST00000527204_length(amino acids)=368AA_BP=19
MLPACQAQEEINMPQLLISKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMNGAGFQKGLTCESCHTTQSAQWYAWGPPNMQCRL
CASCWIYWKKYGGLKTPTQLEGATRGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAAR
RPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDLVAQAPLKPKTPRGTKTPINRNQLSQNRGLGGIMVKRAYETMAGAGV
PFSANGRPLASGIRSSSQPAAKRQKLNPADAPNPVVFVATKDTRALRKALTHLEMRRAARRPNLPLKVKPTLIAVRPPVPLPAPSHPAST
NEPIVLED

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Fusion Gene PPI Analysis for CAPNS1-MTA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAPNS1-MTA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAPNS1-MTA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCAPNS1C0033578Prostatic Neoplasms1CTD_human
HgeneCAPNS1C0376358Malignant neoplasm of prostate1CTD_human
TgeneC0014175Endometriosis1CTD_human
TgeneC0269102Endometrioma1CTD_human