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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARID1A-BEND5 (FusionGDB2 ID:HG8289TG79656)

Fusion Gene Summary for ARID1A-BEND5

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID1A-BEND5
Fusion gene ID: hg8289tg79656
HgeneTgene
Gene symbol

ARID1A

BEND5

Gene ID

8289

79656

Gene nameAT-rich interaction domain 1ABEN domain containing 5
SynonymsB120|BAF250|BAF250a|BM029|C1orf4|CSS2|ELD|MRD14|OSA1|P270|SMARCF1|hELD|hOSA1C1orf165
Cytomap('ARID1A')('BEND5')

1p36.11

1p33

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 1AARID domain-containing protein 1AAT rich interactive domain 1A (SWI-like)BRG1-associated factor 250aOSA1 nuclear proteinSWI-like proteinSWI/SNF complex protein p270SWI/SNF-related, matrix-associated, BEN domain-containing protein 5
Modification date2020032920200327
UniProtAcc

O14497

.
Ensembl transtripts involved in fusion geneENST00000324856, ENST00000457599, 
ENST00000374152, ENST00000540690, 
Fusion gene scores* DoF score29 X 19 X 15=82654 X 5 X 4=80
# samples 457
** MAII scorelog2(45/8265*10)=-4.19901791296264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/80*10)=-0.192645077942396
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARID1A [Title/Abstract] AND BEND5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARID1A(27024031)-BEND5(49202124), # samples:3
Anticipated loss of major functional domain due to fusion event.ARID1A-BEND5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID1A-BEND5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID1A-BEND5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID1A-BEND5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARID1A

GO:0006337

nucleosome disassembly

8895581

HgeneARID1A

GO:0006338

chromatin remodeling

11726552

HgeneARID1A

GO:0030520

intracellular estrogen receptor signaling pathway

12200431

HgeneARID1A

GO:0030521

androgen receptor signaling pathway

12200431

HgeneARID1A

GO:0042921

glucocorticoid receptor signaling pathway

12200431

HgeneARID1A

GO:0045893

positive regulation of transcription, DNA-templated

12200431

TgeneBEND5

GO:0045892

negative regulation of transcription, DNA-templated

23468431


check buttonFusion gene breakpoints across ARID1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BEND5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-28-2514-01AARID1Achr1

27022592

+BEND5chr1

49202123

-
ChimerDB4GBMTCGA-28-2514-01AARID1Achr1

27024031

-BEND5chr1

49202124

-
ChimerDB4GBMTCGA-28-2514-01AARID1Achr1

27024031

+BEND5chr1

49202124

-
ChimerDB4GBMTCGA-28-2514ARID1Achr1

27024031

+BEND5chr1

49202124

-


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Fusion Gene ORF analysis for ARID1A-BEND5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000324856ENST00000476096ARID1Achr1

27024031

+BEND5chr1

49202124

-
5CDS-intronENST00000457599ENST00000476096ARID1Achr1

27024031

+BEND5chr1

49202124

-
5UTR-3CDSENST00000324856ENST00000371833ARID1Achr1

27022592

+BEND5chr1

49202123

-
5UTR-intronENST00000324856ENST00000476096ARID1Achr1

27022592

+BEND5chr1

49202123

-
In-frameENST00000324856ENST00000371833ARID1Achr1

27024031

+BEND5chr1

49202124

-
In-frameENST00000457599ENST00000371833ARID1Achr1

27024031

+BEND5chr1

49202124

-
intron-3CDSENST00000374152ENST00000371833ARID1Achr1

27022592

+BEND5chr1

49202123

-
intron-3CDSENST00000374152ENST00000371833ARID1Achr1

27024031

+BEND5chr1

49202124

-
intron-3CDSENST00000457599ENST00000371833ARID1Achr1

27022592

+BEND5chr1

49202123

-
intron-3CDSENST00000540690ENST00000371833ARID1Achr1

27022592

+BEND5chr1

49202123

-
intron-3CDSENST00000540690ENST00000371833ARID1Achr1

27024031

+BEND5chr1

49202124

-
intron-intronENST00000374152ENST00000476096ARID1Achr1

27022592

+BEND5chr1

49202123

-
intron-intronENST00000374152ENST00000476096ARID1Achr1

27024031

+BEND5chr1

49202124

-
intron-intronENST00000457599ENST00000476096ARID1Achr1

27022592

+BEND5chr1

49202123

-
intron-intronENST00000540690ENST00000476096ARID1Achr1

27022592

+BEND5chr1

49202123

-
intron-intronENST00000540690ENST00000476096ARID1Achr1

27024031

+BEND5chr1

49202124

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000324856ARID1Achr127024031+ENST00000371833BEND5chr149202124-224315083711879502
ENST00000457599ARID1Achr127024031+ENST00000371833BEND5chr149202124-1872113701508502

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000324856ENST00000371833ARID1Achr127024031+BEND5chr149202124-0.0124146390.9875853
ENST00000457599ENST00000371833ARID1Achr127024031+BEND5chr149202124-0.0121983050.98780173

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Fusion Genomic Features for ARID1A-BEND5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARID1A-BEND5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:27024031/chr1:49202124)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARID1A

O14497

.
FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+120295_2993792286.0MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+120295_2993792069.0MotifNote=LXXLL
TgeneBEND5chr1:27024031chr1:49202124ENST0000037183336302_408298422.0DomainBEN

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+1201327_14043792286.0Compositional biasNote=Gln-rich
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+120479_4823792286.0Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+120561_5673792286.0Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+120998_10013792286.0Compositional biasNote=Poly-Ser
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+1191327_140401903.0Compositional biasNote=Gln-rich
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+119479_48201903.0Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+119561_56701903.0Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+119998_100101903.0Compositional biasNote=Poly-Ser
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+1201327_14043792069.0Compositional biasNote=Gln-rich
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+120479_4823792069.0Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+120561_5673792069.0Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+120998_10013792069.0Compositional biasNote=Poly-Ser
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+1201017_11083792286.0DomainARID
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+1191017_110801903.0DomainARID
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+1201017_11083792069.0DomainARID
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+1201368_13873792286.0MotifNuclear localization signal
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+1201709_17133792286.0MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+1201967_19713792286.0MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+1202085_20893792286.0MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+1191368_138701903.0MotifNuclear localization signal
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+1191709_171301903.0MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+1191967_197101903.0MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+1192085_208901903.0MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+119295_29901903.0MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+1201368_13873792069.0MotifNuclear localization signal
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+1201709_17133792069.0MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+1201967_19713792069.0MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+1202085_20893792069.0MotifNote=LXXLL
TgeneBEND5chr1:27024031chr1:49202124ENST0000037183336180_243298422.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for ARID1A-BEND5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6371_6371_1_ARID1A-BEND5_ARID1A_chr1_27024031_ENST00000324856_BEND5_chr1_49202124_ENST00000371833_length(transcript)=2243nt_BP=1508nt
GAAAGCGGAGAGTCACAGCGGGGCCAGGCCCTGGGGAGCGGAGCCTCCACCGCCCCCCTCATTCCCAGGCAAGGGCTTGGGGGGAATGAG
CCGGGAGAGCCGGGTCCCGAGCCTACAGAGCCGGGAGCAGCTGAGCCGCCGGCGCCTCGGCCGCCGCCGCCGCCTCCTCCTCCTCCGCCG
CCGCCAGCCCGGAGCCTGAGCCGGCGGGGCGGGGGGGAGAGGAGCGAGCGCAGCGCAGCAGCGGAGCCCCGCGAGGCCCGCCCGGGCGGG
TGGGGAGGGCAGCCCGGGGGACTGGGCCCCGGGGCGGGGTGGGAGGGGGGGAGAAGACGAAGACAGGGCCGGGTCTCTCCGCGGACGAGA
CAGCGGGGATCATGGCCGCGCAGGTCGCCCCCGCCGCCGCCAGCAGCCTGGGCAACCCGCCGCCGCCGCCGCCCTCGGAGCTGAAGAAAG
CCGAGCAGCAGCAGCGGGAGGAGGCGGGGGGCGAGGCGGCGGCGGCGGCAGCGGCCGAGCGCGGGGAAATGAAGGCAGCCGCCGGGCAGG
AAAGCGAGGGCCCCGCCGTGGGGCCGCCGCAGCCGCTGGGAAAGGAGCTGCAGGACGGGGCCGAGAGCAATGGGGGTGGCGGCGGCGGCG
GAGCCGGCAGCGGCGGCGGGCCCGGCGCGGAGCCGGACCTGAAGAACTCGAACGGGAACGCGGGCCCTAGGCCCGCCCTGAACAATAACC
TCACGGAGCCGCCCGGCGGCGGCGGTGGCGGCAGCAGCGATGGGGTGGGGGCGCCTCCTCACTCAGCCGCGGCCGCCTTGCCGCCCCCAG
CCTACGGCTTCGGGCAACCCTACGGCCGGAGCCCGTCTGCCGTCGCCGCCGCCGCGGCCGCCGTCTTCCACCAACAACATGGCGGACAAC
AAAGCCCTGGCCTGGCAGCGCTGCAGAGCGGCGGCGGCGGGGGCCTGGAGCCCTACGCGGGGCCCCAGCAGAACTCTCACGACCACGGCT
TCCCCAACCACCAGTACAACTCCTACTACCCCAACCGCAGCGCCTACCCCCCGCCCGCCCCGGCCTACGCGCTGAGCTCCCCGAGAGGTG
GCACTCCGGGCTCCGGCGCGGCGGCGGCTGCCGGCTCCAAGCCGCCTCCCTCCTCCAGCGCCTCCGCCTCCTCGTCGTCTTCGTCCTTCG
CTCAGCAGCGCTTCGGGGCCATGGGGGGAGGCGGCCCCTCCGCGGCCGGCGGGGGAACTCCCCAGCCCACCGCCACCCCCACCCTCAACC
AACTGCTCACGTCGCCCAGCTCGGCCCGGGGCTACCAGGGCTACCCCGGGGGCGACTACAGTGGCGGGCCCCAGGACGGGGGCGCCGGCA
AGGGCCCGGCGGACATGGCCTCGCAGTGTTGGGGGGCTGCGGCGGCGGCAGCTGCGGCGGCGGCCGCCTCGGGAGGGGCCCAACAAAGGA
GCCACCACGCGCCCATGAGCCCCGGGAGCAGCGGCGGCGGGGGGCAGCCGCTCGCCCGGACCCCTCAGGTCCATCTGGGAAGCGGGATTT
GGGTTGATGAGGAGAAATGGCACCAGCTACAAGTAACCCAAGGAGATTCCAAGTACACGAAGAACTTGGCAGTTATGATTTGGGGAACAG
ATGTTCTGAAAAACAGAAGCGTCACAGGCGTCGCCACAAAAAAAAAGAAAGATGCAGTCCCTAAACCACCCCTCTCGCCTCACAAACTAA
GCATCGTCAGAGAGTGTTTGTATGACAGAATAGCACAAGAAACTGTGGATGAAACTGAAATTGCACAGAGACTCTCCAAAGTCAACAAGT
ACATCTGTGAAAAAATCATGGATATCAATAAATCCTGTAAAAATGAAGAACGAAGGGAAGCAAAATACAATTTGCAATAAACTTTGGATT
TTTCATAAAGCTTTCGTGTTTTCCTTGTGTGGCATGTGATTTGCGAGCGATGGTGCCGTCCAAATCAGACCCCACCGTGCATGGTGGTGT
GTGTGCAGGGATCCATCGGGTTCTGGGGTCAGCGGCTTGTTCTGAATGTGGACACTCCAAAGACGACAGATGGCTTTGCTGAGACTCAGG
AGCAGCCTGGCACTGGTGTCCTTCTGGGAATGGGGAAAACACTCTTCTTGGAGGGGGATAAGGTTGCCTGAGTTGCCTGTCACTTGACTG

>6371_6371_1_ARID1A-BEND5_ARID1A_chr1_27024031_ENST00000324856_BEND5_chr1_49202124_ENST00000371833_length(amino acids)=502AA_BP=378
MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGS
GGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPG
LAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQR
FGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHA
PMSPGSSGGGGQPLARTPQVHLGSGIWVDEEKWHQLQVTQGDSKYTKNLAVMIWGTDVLKNRSVTGVATKKKKDAVPKPPLSPHKLSIVR

--------------------------------------------------------------
>6371_6371_2_ARID1A-BEND5_ARID1A_chr1_27024031_ENST00000457599_BEND5_chr1_49202124_ENST00000371833_length(transcript)=1872nt_BP=1137nt
ATGGCCGCGCAGGTCGCCCCCGCCGCCGCCAGCAGCCTGGGCAACCCGCCGCCGCCGCCGCCCTCGGAGCTGAAGAAAGCCGAGCAGCAG
CAGCGGGAGGAGGCGGGGGGCGAGGCGGCGGCGGCGGCAGCGGCCGAGCGCGGGGAAATGAAGGCAGCCGCCGGGCAGGAAAGCGAGGGC
CCCGCCGTGGGGCCGCCGCAGCCGCTGGGAAAGGAGCTGCAGGACGGGGCCGAGAGCAATGGGGGTGGCGGCGGCGGCGGAGCCGGCAGC
GGCGGCGGGCCCGGCGCGGAGCCGGACCTGAAGAACTCGAACGGGAACGCGGGCCCTAGGCCCGCCCTGAACAATAACCTCACGGAGCCG
CCCGGCGGCGGCGGTGGCGGCAGCAGCGATGGGGTGGGGGCGCCTCCTCACTCAGCCGCGGCCGCCTTGCCGCCCCCAGCCTACGGCTTC
GGGCAACCCTACGGCCGGAGCCCGTCTGCCGTCGCCGCCGCCGCGGCCGCCGTCTTCCACCAACAACATGGCGGACAACAAAGCCCTGGC
CTGGCAGCGCTGCAGAGCGGCGGCGGCGGGGGCCTGGAGCCCTACGCGGGGCCCCAGCAGAACTCTCACGACCACGGCTTCCCCAACCAC
CAGTACAACTCCTACTACCCCAACCGCAGCGCCTACCCCCCGCCCGCCCCGGCCTACGCGCTGAGCTCCCCGAGAGGTGGCACTCCGGGC
TCCGGCGCGGCGGCGGCTGCCGGCTCCAAGCCGCCTCCCTCCTCCAGCGCCTCCGCCTCCTCGTCGTCTTCGTCCTTCGCTCAGCAGCGC
TTCGGGGCCATGGGGGGAGGCGGCCCCTCCGCGGCCGGCGGGGGAACTCCCCAGCCCACCGCCACCCCCACCCTCAACCAACTGCTCACG
TCGCCCAGCTCGGCCCGGGGCTACCAGGGCTACCCCGGGGGCGACTACAGTGGCGGGCCCCAGGACGGGGGCGCCGGCAAGGGCCCGGCG
GACATGGCCTCGCAGTGTTGGGGGGCTGCGGCGGCGGCAGCTGCGGCGGCGGCCGCCTCGGGAGGGGCCCAACAAAGGAGCCACCACGCG
CCCATGAGCCCCGGGAGCAGCGGCGGCGGGGGGCAGCCGCTCGCCCGGACCCCTCAGGTCCATCTGGGAAGCGGGATTTGGGTTGATGAG
GAGAAATGGCACCAGCTACAAGTAACCCAAGGAGATTCCAAGTACACGAAGAACTTGGCAGTTATGATTTGGGGAACAGATGTTCTGAAA
AACAGAAGCGTCACAGGCGTCGCCACAAAAAAAAAGAAAGATGCAGTCCCTAAACCACCCCTCTCGCCTCACAAACTAAGCATCGTCAGA
GAGTGTTTGTATGACAGAATAGCACAAGAAACTGTGGATGAAACTGAAATTGCACAGAGACTCTCCAAAGTCAACAAGTACATCTGTGAA
AAAATCATGGATATCAATAAATCCTGTAAAAATGAAGAACGAAGGGAAGCAAAATACAATTTGCAATAAACTTTGGATTTTTCATAAAGC
TTTCGTGTTTTCCTTGTGTGGCATGTGATTTGCGAGCGATGGTGCCGTCCAAATCAGACCCCACCGTGCATGGTGGTGTGTGTGCAGGGA
TCCATCGGGTTCTGGGGTCAGCGGCTTGTTCTGAATGTGGACACTCCAAAGACGACAGATGGCTTTGCTGAGACTCAGGAGCAGCCTGGC
ACTGGTGTCCTTCTGGGAATGGGGAAAACACTCTTCTTGGAGGGGGATAAGGTTGCCTGAGTTGCCTGTCACTTGACTGGGGTTTGAATG

>6371_6371_2_ARID1A-BEND5_ARID1A_chr1_27024031_ENST00000457599_BEND5_chr1_49202124_ENST00000371833_length(amino acids)=502AA_BP=378
MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGS
GGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPG
LAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQR
FGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHA
PMSPGSSGGGGQPLARTPQVHLGSGIWVDEEKWHQLQVTQGDSKYTKNLAVMIWGTDVLKNRSVTGVATKKKKDAVPKPPLSPHKLSIVR

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Fusion Gene PPI Analysis for ARID1A-BEND5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARID1A-BEND5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARID1A-BEND5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARID1AC0024623Malignant neoplasm of stomach3CTD_human
HgeneARID1AC0038356Stomach Neoplasms3CTD_human
HgeneARID1AC1708349Hereditary Diffuse Gastric Cancer3CTD_human
HgeneARID1AC2239176Liver carcinoma3CTD_human
HgeneARID1AC0033578Prostatic Neoplasms2CTD_human
HgeneARID1AC0376358Malignant neoplasm of prostate2CTD_human
HgeneARID1AC0001418Adenocarcinoma1CTD_human
HgeneARID1AC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneARID1AC0005695Bladder Neoplasm1CTD_human
HgeneARID1AC0006413Burkitt Lymphoma1CTD_human
HgeneARID1AC0007138Carcinoma, Transitional Cell1CTD_human
HgeneARID1AC0009402Colorectal Carcinoma1CTD_human
HgeneARID1AC0009404Colorectal Neoplasms1CTD_human
HgeneARID1AC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneARID1AC0014170Endometrial Neoplasms1CTD_human
HgeneARID1AC0027708Nephroblastoma1CTD_human
HgeneARID1AC0027819Neuroblastoma1CTD_human
HgeneARID1AC0036920Sezary Syndrome1CTD_human
HgeneARID1AC0079772T-Cell Lymphoma1CTD_human
HgeneARID1AC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneARID1AC0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneARID1AC0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneARID1AC0205643Carcinoma, Cribriform1CTD_human
HgeneARID1AC0205644Carcinoma, Granular Cell1CTD_human
HgeneARID1AC0205645Adenocarcinoma, Tubular1CTD_human
HgeneARID1AC0206656Embryonal Rhabdomyosarcoma1CTD_human
HgeneARID1AC0206698Cholangiocarcinoma1CTD_human
HgeneARID1AC0265338Coffin-Siris syndrome1CTD_human;GENOMICS_ENGLAND
HgeneARID1AC0279628Adenocarcinoma Of Esophagus1CTD_human
HgeneARID1AC0343640African Burkitt's lymphoma1CTD_human
HgeneARID1AC0345905Intrahepatic Cholangiocarcinoma1CTD_human
HgeneARID1AC0376407Granulomatous Slack Skin1CTD_human
HgeneARID1AC0476089Endometrial Carcinoma1CTD_human
HgeneARID1AC0920269Microsatellite Instability1CTD_human
HgeneARID1AC1721098Replication Error Phenotype1CTD_human
HgeneARID1AC2930471Bilateral Wilms Tumor1CTD_human
HgeneARID1AC2931822Nasopharyngeal carcinoma1CTD_human
HgeneARID1AC3805278Extrahepatic Cholangiocarcinoma1CTD_human
HgeneARID1AC4721444Burkitt Leukemia1CTD_human