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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAPZA1-CLCC1 (FusionGDB2 ID:HG829TG23155)

Fusion Gene Summary for CAPZA1-CLCC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPZA1-CLCC1
Fusion gene ID: hg829tg23155
HgeneTgene
Gene symbol

CAPZA1

CLCC1

Gene ID

829

23155

Gene namecapping actin protein of muscle Z-line subunit alpha 1chloride channel CLIC like 1
SynonymsCAPPA1|CAPZ|CAZ1MCLC
Cytomap('CAPZA1')('CLCC1')

1p13.2

1p13.3

Type of geneprotein-codingprotein-coding
DescriptionF-actin-capping protein subunit alpha-1Cap ZcapZ alpha-1capping actin protein of muscle Z-line alpha subunit 1capping protein (actin filament) muscle Z-line, alpha 1chloride channel CLIC-like protein 1Mid-1-related chloride channel protein 1
Modification date2020032720200313
UniProtAcc

P52907

.
Ensembl transtripts involved in fusion geneENST00000476936, ENST00000263168, 
Fusion gene scores* DoF score15 X 8 X 7=8402 X 2 X 2=8
# samples 152
** MAII scorelog2(15/840*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: CAPZA1 [Title/Abstract] AND CLCC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAPZA1(113162505)-CLCC1(109490340), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CAPZA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CLCC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A891CAPZA1chr1

113162505

+CLCC1chr1

109490340

-


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Fusion Gene ORF analysis for CAPZA1-CLCC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000476936ENST00000356970CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
3UTR-3CDSENST00000476936ENST00000369968CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
3UTR-3CDSENST00000476936ENST00000369969CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
3UTR-3CDSENST00000476936ENST00000369971CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
3UTR-3CDSENST00000476936ENST00000369976CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
3UTR-3CDSENST00000476936ENST00000415331CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
3UTR-intronENST00000476936ENST00000302500CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
3UTR-intronENST00000476936ENST00000348264CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
3UTR-intronENST00000476936ENST00000369970CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
3UTR-intronENST00000476936ENST00000482889CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
5CDS-intronENST00000263168ENST00000302500CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
5CDS-intronENST00000263168ENST00000348264CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
5CDS-intronENST00000263168ENST00000369970CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
5CDS-intronENST00000263168ENST00000482889CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
In-frameENST00000263168ENST00000356970CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
In-frameENST00000263168ENST00000369968CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
In-frameENST00000263168ENST00000369969CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
In-frameENST00000263168ENST00000369971CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
In-frameENST00000263168ENST00000369976CAPZA1chr1

113162505

+CLCC1chr1

109490340

-
In-frameENST00000263168ENST00000415331CAPZA1chr1

113162505

+CLCC1chr1

109490340

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263168CAPZA1chr1113162505+ENST00000369968CLCC1chr1109490340-46207115581580340
ENST00000263168CAPZA1chr1113162505+ENST00000369969CLCC1chr1109490340-48127115581772404
ENST00000263168CAPZA1chr1113162505+ENST00000356970CLCC1chr1109490340-51757115582135525
ENST00000263168CAPZA1chr1113162505+ENST00000415331CLCC1chr1109490340-50257115581985475
ENST00000263168CAPZA1chr1113162505+ENST00000369971CLCC1chr1109490340-51757115582135525
ENST00000263168CAPZA1chr1113162505+ENST00000369976CLCC1chr1109490340-26867115581268236

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263168ENST00000369968CAPZA1chr1113162505+CLCC1chr1109490340-0.0007854610.99921453
ENST00000263168ENST00000369969CAPZA1chr1113162505+CLCC1chr1109490340-0.0008559340.9991441
ENST00000263168ENST00000356970CAPZA1chr1113162505+CLCC1chr1109490340-0.0002791560.9997209
ENST00000263168ENST00000415331CAPZA1chr1113162505+CLCC1chr1109490340-0.0007880360.9992119
ENST00000263168ENST00000369971CAPZA1chr1113162505+CLCC1chr1109490340-0.0002791560.9997209
ENST00000263168ENST00000369976CAPZA1chr1113162505+CLCC1chr1109490340-0.0018091270.9981908

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Fusion Genomic Features for CAPZA1-CLCC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CAPZA1-CLCC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:113162505/chr1:109490340)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPZA1

P52907

.
FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. {ECO:0000269|PubMed:22891260}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCLCC1chr1:113162505chr1:109490340ENST0000030250018185_20577431.0TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST0000030250018217_23777431.0TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST0000030250018330_35077431.0TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST0000034826416185_20577367.0TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST0000034826416217_23777367.0TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST0000034826416330_35077367.0TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST00000356970212185_205771577.0TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST00000356970212217_237771577.0TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST00000356970212330_350771577.0TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST0000036996817185_205771393.6666666666667TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST0000036996817217_237771393.6666666666667TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST0000036996817330_350771393.6666666666667TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST0000036996919185_205771457.6666666666667TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST0000036996919217_237771457.6666666666667TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST0000036996919330_350771457.6666666666667TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST00000369970111185_20577699.3333333333334TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST00000369970111217_23777699.3333333333334TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST00000369970111330_35077699.3333333333334TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST00000369971212185_205771569.6666666666667TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST00000369971212217_237771569.6666666666667TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST00000369971212330_350771569.6666666666667TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST00000415331212185_205771516.3333333333333TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST00000415331212217_237771516.3333333333333TransmembraneHelical
TgeneCLCC1chr1:113162505chr1:109490340ENST00000415331212330_350771516.3333333333333TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CAPZA1-CLCC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12961_12961_1_CAPZA1-CLCC1_CAPZA1_chr1_113162505_ENST00000263168_CLCC1_chr1_109490340_ENST00000356970_length(transcript)=5175nt_BP=711nt
GGGAATCCTGGGATAGTGGCGGACCTGAAGTTGGCCTCTGTGAAGGCTGAGTCCTGGGGAACCGGGACCGAGAAGATTTCGAAGGTGGAG
GAGCGTGTCTCAAGATTGGGGCTACCTGTTCTTTCGTGGGGCAGGGAAGGGGCGGACAGCAGCGCCTATTCTGGAGGAACTGGACTGAGA
TGTGACCCCGAAGTGTTACCGCTTCCAAACGAAATGAGGGTCACCTTTCACACCGCCCCCCCCCCGGGGTTGGAAAAGCCACCGATCGTT
CCAGCTGCCGAGCAGCTCTTAAAGCTTTGGATTCGGCTGTCGTGGAGATAACGGGCACCAGAAAAACTTGTAGGAGTAGCAACAGCTATT
TGGTCGGATGGAGGCCAGAAGCCAAGAATAATCGAAACACGCTGCCAGCGCCCATTAGATGGATGGGAAATGAGTGTAACTCATTGGGAA
AGATATTAGACTTCAAATCACCTAAGGCAAACCCTACTTCCTGGGGCGCGGGCGCGGGCGCTGGCGTTAGGAGACGTCACTCCCGCGCAT
AACTGACATGGGGCCCTCTTGGTCGGCGTTTCCGGGCGGGTCCTTCCGACGGCCGCCGCGGTGATTCCATCACTCGGCTTTCTTCCCGGC
CTGCCTCGCGCCCGTAGCCGGGCTGGGCCAGAACAGCCCAAGATGGCCGACTTCGATGATCGTGTGTCGGATGAGGAGAAGATTGATGAG
TGTGAAAAGAAAAAGAGGGAAGACTATGAAAGTCAAAGCAATCCTGTTTTTAGGAGATACTTAAATAAGATTTTAATTGAAGCTGGAAAG
CTTGGACTTCCTGATGAAAACAAAGGCGATATGCATTATGATGCTGAGATTATCCTTAAAAGAGAAACTTTGTTAGAAATACAGAAGTTT
CTCAATGGAGAAGACTGGAAACCAGGTGCCTTGGATGATGCACTAAGTGATATTTTAATTAATTTTAAGTTTCATGATTTTGAAACATGG
AAGTGGCGATTCGAAGATTCCTTTGGAGTGGATCCATATAATGTGTTAATGGTACTTCTTTGTCTGCTCTGCATCGTGGTTTTAGTGGCT
ACTGAGCTGTGGACATATGTACGTTGGTACACTCAGTTGAGACGTGTTTTAATCATCAGCTTTCTGTTCAGTTTGGGATGGAATTGGATG
TATTTATATAAGCTAGCTTTTGCACAGCATCAGGCTGAAGTCGCCAAGATGGAGCCATTAAACAATGTGTGTGCCAAAAAGATGGACTGG
ACTGGAAGTATCTGGGAATGGTTTAGAAGTTCATGGACCTATAAGGATGACCCATGCCAAAAATACTATGAGCTCTTACTAGTCAACCCT
ATTTGGTTGGTCCCACCAACAAAGGCACTTGCAGTTACATTCACCACATTTGTAACGGAGCCATTGAAGCATATTGGAAAAGGAACTGGG
GAATTTATTAAAGCACTCATGAAGGAAATTCCAGCGCTGCTTCATCTTCCAGTGCTGATAATTATGGCATTAGCCATCCTGAGTTTCTGC
TATGGTGCTGGAAAATCAGTTCATGTGCTGAGACATATAGGCGGTCCTGAGAGCGAACCTCCCCAGGCACTTCGGCCACGGGATAGAAGA
CGGCAGGAGGAAATTGATTATAGACCTGATGGTGGAGCAGGTGATGCCGATTTCCATTATAGGGGCCAAATGGGCCCCACTGAGCAAGGC
CCTTATGCCAAAACGTATGAGGGTAGAAGAGAGATTTTGAGAGAGAGAGATGTTGACTTGAGATTTCAGACTGGCAACAAGAGCCCTGAA
GTGCTCCGGGCATTTGATGTACCAGACGCAGAGGCACGAGAGCATCCCACGGTGGTACCCAGTCATAAATCACCTGTTTTGGATACAAAG
CCCAAGGAGACAGGTGGAATCCTGGGGGAAGGCACACCGAAAGAAAGCAGTACTGAAAGCAGCCAGTCGGCCAAGCCTGTCTCTGGCCAA
GACACATCAGGGAATACAGAAGGTTCACCCGCAGCGGAAAAGGCCCAGCTCAAGTCTGAAGCCGCAGGCAGCCCAGACCAAGGCAGCACA
TACAGCCCCGCAAGAGGTGTGGCTGGACCACGTGGACAGGATCCGGTCAGCAGCCCCTGTGGCTAGAGGAACACCAGCACAAACGACAGC
CTCAAGTCTCCTTCGAGCTTTATATCCATTTGGGGATGAAGTCTACTTTGACAGCTAGCAAGGCGACATGCAACTGTTGTTGAATGATGA
CAGCAATTCAGGAAAGACTTAAATATGAAAGCAAATTGAACACATCGGGTGTTTGTTATCAGAAAAGAGATGAGATGAGATAAGACTTGT
TTATTGACTAGCCAATATGTCATTAAAATTAAGGTTTATATTGTGAAGCTTTTTTGAAATTTTACTTTTTTTTGAGAGTTTTGCTCTGTC
ACCCAGGCTGGAGTGAGGTGGTACAATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGAGATTCTCCTGCCTCAGTCTCCCGAGT
AGCTAGGATTACAGATGTGCATCACCATGCCTGGCTAATTTTTGTATTTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGCTGGTC
TCGAACTCCTGACCTCAAGTGACCCGCCCTTGTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATTGTGCCCAGCCTATATAGT
GTGAAGCTTTTAGGAAAATCAGAACAGGGTAGACAGCTGTTAAAAACAATGTTTAAATGGAATAATGTTGAATGTTTACAGGCTGTAAGA
ACTATTGTATACACAAAATAATACACAAAGTTTGTACTTTGTGTACAAATACAAATTTGTACTTTGTGTACAAATAATACAAAAAGTTTG
TATACACAAACTTTTTACGTTGTGGTTTGGTATATTGTCTTAACTGAATTTTCTTATAAGAACCCCATGAAACTTACCTGAGTTTTTAAA
ATGCTATCCAGGACATCATACCTTATAGTATACATGAAACATAATGTAATCCAGGTTGTAATTTAGAACTTTTTTTTTTTTTTTAGCTGA
GCACTTAATGTAATTAATTCCAGGTTATGACTCTTAAAAAACATTGGCCATTAGAGAAATAGTTCTATTTGCCCATCCAAATCACCTGAA
TGACTTTTTGAAAGAATAGGGGTCCACATCCCCAGATCCCATCCCAGCTGTGCACAGTCTGAAGCAAGCAGAGTGAAACAAGTTGGCAAC
TTGTTCCAAGCGTGGGCCTTTGCAGTCTGTGATCCAGTGTTACTCCAGGTCCCAGTCTGTCCCATACTTGTCTTTTGCTACAGTTAGTTA
GTTACTTTGTTATCATCCCCTTGTAAACTGCCTTCAATATCTGGGATAAGGAAGACAAAGCTTAATGACAACTAAGGTTCTAGCTGACAT
CTTTCTTTCATATTTAATTTTTGTGAGTTTTCATCTGTTTTCTGTTTGTTTATGTGTCCTAGGTTCTTGACCTAACCACATGGGTTTTGT
TTTTTGTTTTTATATTAGAACTTAGAAAAGTTTGTTTTACAGCAGTATTATGGAACAGAAGAGACCATTTTAAATAATTTTTTTAAACAG
CCCAAAACACACAAAAGATACTTGTTTTCTAGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACGATCATAGCTCAGT
GCAGCCTCCACCTCCTGGGCTCAAGTGGTCCTCCTGCCTCAGCCTCTTAAGCAGTTGGGACTACAGGTGTGTGCCAGCATGCTTGCTGTT
TTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCACTCAGGCTGGAGTCCAGTGGCTTGGTCTCAGCTCACTGCAATCTCTGCCTCCCAGG
GGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGAAACTACAGGCGCATGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTA
GAGACAGGGTTTCACTATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAAGTGATCCGCCCGCTTCGGCCTCCCAAAGTGCTGGGATT
ACAGGTGTGAGCCACTGCGCCTGGCTGCTGATTTATTTTTCATAGACACGGGGGTCTATGTTGCCCAGGTTGGTCTTGAACTCCTAGCCT
CAAGCGATCCTCCTGCCTCAGCCTCCCAATGTGCTGGGATTACAGGAATGAGCCACCATGCCCAGCCCAAGAAGTAGAGTTTCTTTTATA
CTGACTTTGGCCTAAAAAAACAGATTTTCATGGAGGAAAAAAAAACCTAGATTTTTAGTAAGACTATTTTATATACTTTTTTACATTGAT
CAAGTACATTATTTTTACCAAACAACATTGTTTCCCACTACATCCATGGTTATGTATAAAAAAACGCCATTGTCAATTAAGATGTTAAAA
AATTATTTCCATAAGAGTATTAAATTCTAATCTATGATTCACTTAACTTCCTACTTTATAAACACTAGGTAAAGTAATCTCACAAGCTGC
CAAAGAACACATCCCAAGCAGTAATCACAGACGATGAAGCACCTTACAGGACCCCTCCACCCTCAAACGCGCATGTCCAGAGAAGTATTA
ATGCCTTAATAGACTACTGAAGGTTAACTATTTACATCATTCTAAAAATATTTTAAGCTGTATTACAGTGCTATAAATTCTCCTTTTAAG
GAAAAAAGTAATAGATTGTTTCCTTACCGTGTTTGAAAGGAAAAAAAATAAATCCATAGTAACTAATGGTCTGCCGATTTTTTCCCTGAA
TTTTTAAACTCCAACAAAGCATTATTTTGCAAAAAGTCCTTTAGCCCAAAGTCAGTGTCTCTGTTTTGATCTCTTTGTAAAAGAACTCTC
TGTTCATCCATTCTCTTTCCCTGGGACCGTAAAATAAGGCTGAAAAAGTCTTCATCTGGTACTGTCGGACCCTTTGTGGTAGCAGGTGGT
GGAGCACATCTTTGATCATCTAATCTGGATCCCTAGAAGTTTATGAGAGAGATTAAAAGACATACTGTGGGAAAGAAAGCACCAAGCTAT
GTTAAATCTCTCAGTCACAACAAGAAAACGCAGTTGTAAACTTTTATTTGGGGCTTCTCAGAAATTAATCTTTGTTTTTATATTGTTCTC

>12961_12961_1_CAPZA1-CLCC1_CAPZA1_chr1_113162505_ENST00000263168_CLCC1_chr1_109490340_ENST00000356970_length(amino acids)=525AA_BP=51
MVGVSGRVLPTAAAVIPSLGFLPGLPRARSRAGPEQPKMADFDDRVSDEEKIDECEKKKREDYESQSNPVFRRYLNKILIEAGKLGLPDE
NKGDMHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINFKFHDFETWKWRFEDSFGVDPYNVLMVLLCLLCIVVLVATELWTY
VRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQHQAEVAKMEPLNNVCAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPP
TKALAVTFTTFVTEPLKHIGKGTGEFIKALMKEIPALLHLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEID
YRPDGGAGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGG

--------------------------------------------------------------
>12961_12961_2_CAPZA1-CLCC1_CAPZA1_chr1_113162505_ENST00000263168_CLCC1_chr1_109490340_ENST00000369968_length(transcript)=4620nt_BP=711nt
GGGAATCCTGGGATAGTGGCGGACCTGAAGTTGGCCTCTGTGAAGGCTGAGTCCTGGGGAACCGGGACCGAGAAGATTTCGAAGGTGGAG
GAGCGTGTCTCAAGATTGGGGCTACCTGTTCTTTCGTGGGGCAGGGAAGGGGCGGACAGCAGCGCCTATTCTGGAGGAACTGGACTGAGA
TGTGACCCCGAAGTGTTACCGCTTCCAAACGAAATGAGGGTCACCTTTCACACCGCCCCCCCCCCGGGGTTGGAAAAGCCACCGATCGTT
CCAGCTGCCGAGCAGCTCTTAAAGCTTTGGATTCGGCTGTCGTGGAGATAACGGGCACCAGAAAAACTTGTAGGAGTAGCAACAGCTATT
TGGTCGGATGGAGGCCAGAAGCCAAGAATAATCGAAACACGCTGCCAGCGCCCATTAGATGGATGGGAAATGAGTGTAACTCATTGGGAA
AGATATTAGACTTCAAATCACCTAAGGCAAACCCTACTTCCTGGGGCGCGGGCGCGGGCGCTGGCGTTAGGAGACGTCACTCCCGCGCAT
AACTGACATGGGGCCCTCTTGGTCGGCGTTTCCGGGCGGGTCCTTCCGACGGCCGCCGCGGTGATTCCATCACTCGGCTTTCTTCCCGGC
CTGCCTCGCGCCCGTAGCCGGGCTGGGCCAGAACAGCCCAAGATGGCCGACTTCGATGATCGTGTGTCGGATGAGGAGAAGATTGATGAG
TGTGAAAAGAAAAAGAGGGAAGACTATGAAAGTCAAAGCAATCCTGTTTTTAGGAGATACTTAAATAAGATTTTAATTGAAGCTGGAAAG
CTTGGACTTGCACTTGCAGTTACATTCACCACATTTGTAACGGAGCCATTGAAGCATATTGGAAAAGGAACTGGGGAATTTATTAAAGCA
CTCATGAAGGAAATTCCAGCGCTGCTTCATCTTCCAGTGCTGATAATTATGGCATTAGCCATCCTGAGTTTCTGCTATGGTGCTGGAAAA
TCAGTTCATGTGCTGAGACATATAGGCGGTCCTGAGAGCGAACCTCCCCAGGCACTTCGGCCACGGGATAGAAGACGGCAGGAGGAAATT
GATTATAGACCTGATGGTGGAGCAGGTGATGCCGATTTCCATTATAGGGGCCAAATGGGCCCCACTGAGCAAGGCCCTTATGCCAAAACG
TATGAGGGTAGAAGAGAGATTTTGAGAGAGAGAGATGTTGACTTGAGATTTCAGACTGGCAACAAGAGCCCTGAAGTGCTCCGGGCATTT
GATGTACCAGACGCAGAGGCACGAGAGCATCCCACGGTGGTACCCAGTCATAAATCACCTGTTTTGGATACAAAGCCCAAGGAGACAGGT
GGAATCCTGGGGGAAGGCACACCGAAAGAAAGCAGTACTGAAAGCAGCCAGTCGGCCAAGCCTGTCTCTGGCCAAGACACATCAGGGAAT
ACAGAAGGTTCACCCGCAGCGGAAAAGGCCCAGCTCAAGTCTGAAGCCGCAGGCAGCCCAGACCAAGGCAGCACATACAGCCCCGCAAGA
GGTGTGGCTGGACCACGTGGACAGGATCCGGTCAGCAGCCCCTGTGGCTAGAGGAACACCAGCACAAACGACAGCCTCAAGTCTCCTTCG
AGCTTTATATCCATTTGGGGATGAAGTCTACTTTGACAGCTAGCAAGGCGACATGCAACTGTTGTTGAATGATGACAGCAATTCAGGAAA
GACTTAAATATGAAAGCAAATTGAACACATCGGGTGTTTGTTATCAGAAAAGAGATGAGATGAGATAAGACTTGTTTATTGACTAGCCAA
TATGTCATTAAAATTAAGGTTTATATTGTGAAGCTTTTTTGAAATTTTACTTTTTTTTGAGAGTTTTGCTCTGTCACCCAGGCTGGAGTG
AGGTGGTACAATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGAGATTCTCCTGCCTCAGTCTCCCGAGTAGCTAGGATTACAGA
TGTGCATCACCATGCCTGGCTAATTTTTGTATTTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCT
CAAGTGACCCGCCCTTGTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATTGTGCCCAGCCTATATAGTGTGAAGCTTTTAGGA
AAATCAGAACAGGGTAGACAGCTGTTAAAAACAATGTTTAAATGGAATAATGTTGAATGTTTACAGGCTGTAAGAACTATTGTATACACA
AAATAATACACAAAGTTTGTACTTTGTGTACAAATACAAATTTGTACTTTGTGTACAAATAATACAAAAAGTTTGTATACACAAACTTTT
TACGTTGTGGTTTGGTATATTGTCTTAACTGAATTTTCTTATAAGAACCCCATGAAACTTACCTGAGTTTTTAAAATGCTATCCAGGACA
TCATACCTTATAGTATACATGAAACATAATGTAATCCAGGTTGTAATTTAGAACTTTTTTTTTTTTTTTAGCTGAGCACTTAATGTAATT
AATTCCAGGTTATGACTCTTAAAAAACATTGGCCATTAGAGAAATAGTTCTATTTGCCCATCCAAATCACCTGAATGACTTTTTGAAAGA
ATAGGGGTCCACATCCCCAGATCCCATCCCAGCTGTGCACAGTCTGAAGCAAGCAGAGTGAAACAAGTTGGCAACTTGTTCCAAGCGTGG
GCCTTTGCAGTCTGTGATCCAGTGTTACTCCAGGTCCCAGTCTGTCCCATACTTGTCTTTTGCTACAGTTAGTTAGTTACTTTGTTATCA
TCCCCTTGTAAACTGCCTTCAATATCTGGGATAAGGAAGACAAAGCTTAATGACAACTAAGGTTCTAGCTGACATCTTTCTTTCATATTT
AATTTTTGTGAGTTTTCATCTGTTTTCTGTTTGTTTATGTGTCCTAGGTTCTTGACCTAACCACATGGGTTTTGTTTTTTGTTTTTATAT
TAGAACTTAGAAAAGTTTGTTTTACAGCAGTATTATGGAACAGAAGAGACCATTTTAAATAATTTTTTTAAACAGCCCAAAACACACAAA
AGATACTTGTTTTCTAGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACGATCATAGCTCAGTGCAGCCTCCACCTCC
TGGGCTCAAGTGGTCCTCCTGCCTCAGCCTCTTAAGCAGTTGGGACTACAGGTGTGTGCCAGCATGCTTGCTGTTTTTTTTTTTTTTGAG
ACAGAGTCTTGCTCTGTCACTCAGGCTGGAGTCCAGTGGCTTGGTCTCAGCTCACTGCAATCTCTGCCTCCCAGGGGTTCAAGTGATTCT
CCTGCCTCAGCCTCCCAAGTAGCTGAAACTACAGGCGCATGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCAC
TATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAAGTGATCCGCCCGCTTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCAC
TGCGCCTGGCTGCTGATTTATTTTTCATAGACACGGGGGTCTATGTTGCCCAGGTTGGTCTTGAACTCCTAGCCTCAAGCGATCCTCCTG
CCTCAGCCTCCCAATGTGCTGGGATTACAGGAATGAGCCACCATGCCCAGCCCAAGAAGTAGAGTTTCTTTTATACTGACTTTGGCCTAA
AAAAACAGATTTTCATGGAGGAAAAAAAAACCTAGATTTTTAGTAAGACTATTTTATATACTTTTTTACATTGATCAAGTACATTATTTT
TACCAAACAACATTGTTTCCCACTACATCCATGGTTATGTATAAAAAAACGCCATTGTCAATTAAGATGTTAAAAAATTATTTCCATAAG
AGTATTAAATTCTAATCTATGATTCACTTAACTTCCTACTTTATAAACACTAGGTAAAGTAATCTCACAAGCTGCCAAAGAACACATCCC
AAGCAGTAATCACAGACGATGAAGCACCTTACAGGACCCCTCCACCCTCAAACGCGCATGTCCAGAGAAGTATTAATGCCTTAATAGACT
ACTGAAGGTTAACTATTTACATCATTCTAAAAATATTTTAAGCTGTATTACAGTGCTATAAATTCTCCTTTTAAGGAAAAAAGTAATAGA
TTGTTTCCTTACCGTGTTTGAAAGGAAAAAAAATAAATCCATAGTAACTAATGGTCTGCCGATTTTTTCCCTGAATTTTTAAACTCCAAC
AAAGCATTATTTTGCAAAAAGTCCTTTAGCCCAAAGTCAGTGTCTCTGTTTTGATCTCTTTGTAAAAGAACTCTCTGTTCATCCATTCTC
TTTCCCTGGGACCGTAAAATAAGGCTGAAAAAGTCTTCATCTGGTACTGTCGGACCCTTTGTGGTAGCAGGTGGTGGAGCACATCTTTGA
TCATCTAATCTGGATCCCTAGAAGTTTATGAGAGAGATTAAAAGACATACTGTGGGAAAGAAAGCACCAAGCTATGTTAAATCTCTCAGT
CACAACAAGAAAACGCAGTTGTAAACTTTTATTTGGGGCTTCTCAGAAATTAATCTTTGTTTTTATATTGTTCTCTTTAGTTCCCAGCCT

>12961_12961_2_CAPZA1-CLCC1_CAPZA1_chr1_113162505_ENST00000263168_CLCC1_chr1_109490340_ENST00000369968_length(amino acids)=340AA_BP=51
MVGVSGRVLPTAAAVIPSLGFLPGLPRARSRAGPEQPKMADFDDRVSDEEKIDECEKKKREDYESQSNPVFRRYLNKILIEAGKLGLALA
VTFTTFVTEPLKHIGKGTGEFIKALMKEIPALLHLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDG
GAGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEG

--------------------------------------------------------------
>12961_12961_3_CAPZA1-CLCC1_CAPZA1_chr1_113162505_ENST00000263168_CLCC1_chr1_109490340_ENST00000369969_length(transcript)=4812nt_BP=711nt
GGGAATCCTGGGATAGTGGCGGACCTGAAGTTGGCCTCTGTGAAGGCTGAGTCCTGGGGAACCGGGACCGAGAAGATTTCGAAGGTGGAG
GAGCGTGTCTCAAGATTGGGGCTACCTGTTCTTTCGTGGGGCAGGGAAGGGGCGGACAGCAGCGCCTATTCTGGAGGAACTGGACTGAGA
TGTGACCCCGAAGTGTTACCGCTTCCAAACGAAATGAGGGTCACCTTTCACACCGCCCCCCCCCCGGGGTTGGAAAAGCCACCGATCGTT
CCAGCTGCCGAGCAGCTCTTAAAGCTTTGGATTCGGCTGTCGTGGAGATAACGGGCACCAGAAAAACTTGTAGGAGTAGCAACAGCTATT
TGGTCGGATGGAGGCCAGAAGCCAAGAATAATCGAAACACGCTGCCAGCGCCCATTAGATGGATGGGAAATGAGTGTAACTCATTGGGAA
AGATATTAGACTTCAAATCACCTAAGGCAAACCCTACTTCCTGGGGCGCGGGCGCGGGCGCTGGCGTTAGGAGACGTCACTCCCGCGCAT
AACTGACATGGGGCCCTCTTGGTCGGCGTTTCCGGGCGGGTCCTTCCGACGGCCGCCGCGGTGATTCCATCACTCGGCTTTCTTCCCGGC
CTGCCTCGCGCCCGTAGCCGGGCTGGGCCAGAACAGCCCAAGATGGCCGACTTCGATGATCGTGTGTCGGATGAGGAGAAGATTGATGAG
TGTGAAAAGAAAAAGAGGGAAGACTATGAAAGTCAAAGCAATCCTGTTTTTAGGAGATACTTAAATAAGATTTTAATTGAAGCTGGAAAG
CTTGGACTTCTAGCTTTTGCACAGCATCAGGCTGAAGTCGCCAAGATGGAGCCATTAAACAATGTGTGTGCCAAAAAGATGGACTGGACT
GGAAGTATCTGGGAATGGTTTAGAAGTTCATGGACCTATAAGGATGACCCATGCCAAAAATACTATGAGCTCTTACTAGTCAACCCTATT
TGGTTGGTCCCACCAACAAAGGCACTTGCAGTTACATTCACCACATTTGTAACGGAGCCATTGAAGCATATTGGAAAAGGAACTGGGGAA
TTTATTAAAGCACTCATGAAGGAAATTCCAGCGCTGCTTCATCTTCCAGTGCTGATAATTATGGCATTAGCCATCCTGAGTTTCTGCTAT
GGTGCTGGAAAATCAGTTCATGTGCTGAGACATATAGGCGGTCCTGAGAGCGAACCTCCCCAGGCACTTCGGCCACGGGATAGAAGACGG
CAGGAGGAAATTGATTATAGACCTGATGGTGGAGCAGGTGATGCCGATTTCCATTATAGGGGCCAAATGGGCCCCACTGAGCAAGGCCCT
TATGCCAAAACGTATGAGGGTAGAAGAGAGATTTTGAGAGAGAGAGATGTTGACTTGAGATTTCAGACTGGCAACAAGAGCCCTGAAGTG
CTCCGGGCATTTGATGTACCAGACGCAGAGGCACGAGAGCATCCCACGGTGGTACCCAGTCATAAATCACCTGTTTTGGATACAAAGCCC
AAGGAGACAGGTGGAATCCTGGGGGAAGGCACACCGAAAGAAAGCAGTACTGAAAGCAGCCAGTCGGCCAAGCCTGTCTCTGGCCAAGAC
ACATCAGGGAATACAGAAGGTTCACCCGCAGCGGAAAAGGCCCAGCTCAAGTCTGAAGCCGCAGGCAGCCCAGACCAAGGCAGCACATAC
AGCCCCGCAAGAGGTGTGGCTGGACCACGTGGACAGGATCCGGTCAGCAGCCCCTGTGGCTAGAGGAACACCAGCACAAACGACAGCCTC
AAGTCTCCTTCGAGCTTTATATCCATTTGGGGATGAAGTCTACTTTGACAGCTAGCAAGGCGACATGCAACTGTTGTTGAATGATGACAG
CAATTCAGGAAAGACTTAAATATGAAAGCAAATTGAACACATCGGGTGTTTGTTATCAGAAAAGAGATGAGATGAGATAAGACTTGTTTA
TTGACTAGCCAATATGTCATTAAAATTAAGGTTTATATTGTGAAGCTTTTTTGAAATTTTACTTTTTTTTGAGAGTTTTGCTCTGTCACC
CAGGCTGGAGTGAGGTGGTACAATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGAGATTCTCCTGCCTCAGTCTCCCGAGTAGC
TAGGATTACAGATGTGCATCACCATGCCTGGCTAATTTTTGTATTTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGCTGGTCTCG
AACTCCTGACCTCAAGTGACCCGCCCTTGTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATTGTGCCCAGCCTATATAGTGTG
AAGCTTTTAGGAAAATCAGAACAGGGTAGACAGCTGTTAAAAACAATGTTTAAATGGAATAATGTTGAATGTTTACAGGCTGTAAGAACT
ATTGTATACACAAAATAATACACAAAGTTTGTACTTTGTGTACAAATACAAATTTGTACTTTGTGTACAAATAATACAAAAAGTTTGTAT
ACACAAACTTTTTACGTTGTGGTTTGGTATATTGTCTTAACTGAATTTTCTTATAAGAACCCCATGAAACTTACCTGAGTTTTTAAAATG
CTATCCAGGACATCATACCTTATAGTATACATGAAACATAATGTAATCCAGGTTGTAATTTAGAACTTTTTTTTTTTTTTTAGCTGAGCA
CTTAATGTAATTAATTCCAGGTTATGACTCTTAAAAAACATTGGCCATTAGAGAAATAGTTCTATTTGCCCATCCAAATCACCTGAATGA
CTTTTTGAAAGAATAGGGGTCCACATCCCCAGATCCCATCCCAGCTGTGCACAGTCTGAAGCAAGCAGAGTGAAACAAGTTGGCAACTTG
TTCCAAGCGTGGGCCTTTGCAGTCTGTGATCCAGTGTTACTCCAGGTCCCAGTCTGTCCCATACTTGTCTTTTGCTACAGTTAGTTAGTT
ACTTTGTTATCATCCCCTTGTAAACTGCCTTCAATATCTGGGATAAGGAAGACAAAGCTTAATGACAACTAAGGTTCTAGCTGACATCTT
TCTTTCATATTTAATTTTTGTGAGTTTTCATCTGTTTTCTGTTTGTTTATGTGTCCTAGGTTCTTGACCTAACCACATGGGTTTTGTTTT
TTGTTTTTATATTAGAACTTAGAAAAGTTTGTTTTACAGCAGTATTATGGAACAGAAGAGACCATTTTAAATAATTTTTTTAAACAGCCC
AAAACACACAAAAGATACTTGTTTTCTAGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACGATCATAGCTCAGTGCA
GCCTCCACCTCCTGGGCTCAAGTGGTCCTCCTGCCTCAGCCTCTTAAGCAGTTGGGACTACAGGTGTGTGCCAGCATGCTTGCTGTTTTT
TTTTTTTTTGAGACAGAGTCTTGCTCTGTCACTCAGGCTGGAGTCCAGTGGCTTGGTCTCAGCTCACTGCAATCTCTGCCTCCCAGGGGT
TCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGAAACTACAGGCGCATGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAG
ACAGGGTTTCACTATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAAGTGATCCGCCCGCTTCGGCCTCCCAAAGTGCTGGGATTACA
GGTGTGAGCCACTGCGCCTGGCTGCTGATTTATTTTTCATAGACACGGGGGTCTATGTTGCCCAGGTTGGTCTTGAACTCCTAGCCTCAA
GCGATCCTCCTGCCTCAGCCTCCCAATGTGCTGGGATTACAGGAATGAGCCACCATGCCCAGCCCAAGAAGTAGAGTTTCTTTTATACTG
ACTTTGGCCTAAAAAAACAGATTTTCATGGAGGAAAAAAAAACCTAGATTTTTAGTAAGACTATTTTATATACTTTTTTACATTGATCAA
GTACATTATTTTTACCAAACAACATTGTTTCCCACTACATCCATGGTTATGTATAAAAAAACGCCATTGTCAATTAAGATGTTAAAAAAT
TATTTCCATAAGAGTATTAAATTCTAATCTATGATTCACTTAACTTCCTACTTTATAAACACTAGGTAAAGTAATCTCACAAGCTGCCAA
AGAACACATCCCAAGCAGTAATCACAGACGATGAAGCACCTTACAGGACCCCTCCACCCTCAAACGCGCATGTCCAGAGAAGTATTAATG
CCTTAATAGACTACTGAAGGTTAACTATTTACATCATTCTAAAAATATTTTAAGCTGTATTACAGTGCTATAAATTCTCCTTTTAAGGAA
AAAAGTAATAGATTGTTTCCTTACCGTGTTTGAAAGGAAAAAAAATAAATCCATAGTAACTAATGGTCTGCCGATTTTTTCCCTGAATTT
TTAAACTCCAACAAAGCATTATTTTGCAAAAAGTCCTTTAGCCCAAAGTCAGTGTCTCTGTTTTGATCTCTTTGTAAAAGAACTCTCTGT
TCATCCATTCTCTTTCCCTGGGACCGTAAAATAAGGCTGAAAAAGTCTTCATCTGGTACTGTCGGACCCTTTGTGGTAGCAGGTGGTGGA
GCACATCTTTGATCATCTAATCTGGATCCCTAGAAGTTTATGAGAGAGATTAAAAGACATACTGTGGGAAAGAAAGCACCAAGCTATGTT
AAATCTCTCAGTCACAACAAGAAAACGCAGTTGTAAACTTTTATTTGGGGCTTCTCAGAAATTAATCTTTGTTTTTATATTGTTCTCTTT

>12961_12961_3_CAPZA1-CLCC1_CAPZA1_chr1_113162505_ENST00000263168_CLCC1_chr1_109490340_ENST00000369969_length(amino acids)=404AA_BP=51
MVGVSGRVLPTAAAVIPSLGFLPGLPRARSRAGPEQPKMADFDDRVSDEEKIDECEKKKREDYESQSNPVFRRYLNKILIEAGKLGLLAF
AQHQAEVAKMEPLNNVCAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTTFVTEPLKHIGKGTGEFIKALM
KEIPALLHLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYAKTYE
GRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQSAKPVSGQDTSGNTE

--------------------------------------------------------------
>12961_12961_4_CAPZA1-CLCC1_CAPZA1_chr1_113162505_ENST00000263168_CLCC1_chr1_109490340_ENST00000369971_length(transcript)=5175nt_BP=711nt
GGGAATCCTGGGATAGTGGCGGACCTGAAGTTGGCCTCTGTGAAGGCTGAGTCCTGGGGAACCGGGACCGAGAAGATTTCGAAGGTGGAG
GAGCGTGTCTCAAGATTGGGGCTACCTGTTCTTTCGTGGGGCAGGGAAGGGGCGGACAGCAGCGCCTATTCTGGAGGAACTGGACTGAGA
TGTGACCCCGAAGTGTTACCGCTTCCAAACGAAATGAGGGTCACCTTTCACACCGCCCCCCCCCCGGGGTTGGAAAAGCCACCGATCGTT
CCAGCTGCCGAGCAGCTCTTAAAGCTTTGGATTCGGCTGTCGTGGAGATAACGGGCACCAGAAAAACTTGTAGGAGTAGCAACAGCTATT
TGGTCGGATGGAGGCCAGAAGCCAAGAATAATCGAAACACGCTGCCAGCGCCCATTAGATGGATGGGAAATGAGTGTAACTCATTGGGAA
AGATATTAGACTTCAAATCACCTAAGGCAAACCCTACTTCCTGGGGCGCGGGCGCGGGCGCTGGCGTTAGGAGACGTCACTCCCGCGCAT
AACTGACATGGGGCCCTCTTGGTCGGCGTTTCCGGGCGGGTCCTTCCGACGGCCGCCGCGGTGATTCCATCACTCGGCTTTCTTCCCGGC
CTGCCTCGCGCCCGTAGCCGGGCTGGGCCAGAACAGCCCAAGATGGCCGACTTCGATGATCGTGTGTCGGATGAGGAGAAGATTGATGAG
TGTGAAAAGAAAAAGAGGGAAGACTATGAAAGTCAAAGCAATCCTGTTTTTAGGAGATACTTAAATAAGATTTTAATTGAAGCTGGAAAG
CTTGGACTTCCTGATGAAAACAAAGGCGATATGCATTATGATGCTGAGATTATCCTTAAAAGAGAAACTTTGTTAGAAATACAGAAGTTT
CTCAATGGAGAAGACTGGAAACCAGGTGCCTTGGATGATGCACTAAGTGATATTTTAATTAATTTTAAGTTTCATGATTTTGAAACATGG
AAGTGGCGATTCGAAGATTCCTTTGGAGTGGATCCATATAATGTGTTAATGGTACTTCTTTGTCTGCTCTGCATCGTGGTTTTAGTGGCT
ACTGAGCTGTGGACATATGTACGTTGGTACACTCAGTTGAGACGTGTTTTAATCATCAGCTTTCTGTTCAGTTTGGGATGGAATTGGATG
TATTTATATAAGCTAGCTTTTGCACAGCATCAGGCTGAAGTCGCCAAGATGGAGCCATTAAACAATGTGTGTGCCAAAAAGATGGACTGG
ACTGGAAGTATCTGGGAATGGTTTAGAAGTTCATGGACCTATAAGGATGACCCATGCCAAAAATACTATGAGCTCTTACTAGTCAACCCT
ATTTGGTTGGTCCCACCAACAAAGGCACTTGCAGTTACATTCACCACATTTGTAACGGAGCCATTGAAGCATATTGGAAAAGGAACTGGG
GAATTTATTAAAGCACTCATGAAGGAAATTCCAGCGCTGCTTCATCTTCCAGTGCTGATAATTATGGCATTAGCCATCCTGAGTTTCTGC
TATGGTGCTGGAAAATCAGTTCATGTGCTGAGACATATAGGCGGTCCTGAGAGCGAACCTCCCCAGGCACTTCGGCCACGGGATAGAAGA
CGGCAGGAGGAAATTGATTATAGACCTGATGGTGGAGCAGGTGATGCCGATTTCCATTATAGGGGCCAAATGGGCCCCACTGAGCAAGGC
CCTTATGCCAAAACGTATGAGGGTAGAAGAGAGATTTTGAGAGAGAGAGATGTTGACTTGAGATTTCAGACTGGCAACAAGAGCCCTGAA
GTGCTCCGGGCATTTGATGTACCAGACGCAGAGGCACGAGAGCATCCCACGGTGGTACCCAGTCATAAATCACCTGTTTTGGATACAAAG
CCCAAGGAGACAGGTGGAATCCTGGGGGAAGGCACACCGAAAGAAAGCAGTACTGAAAGCAGCCAGTCGGCCAAGCCTGTCTCTGGCCAA
GACACATCAGGGAATACAGAAGGTTCACCCGCAGCGGAAAAGGCCCAGCTCAAGTCTGAAGCCGCAGGCAGCCCAGACCAAGGCAGCACA
TACAGCCCCGCAAGAGGTGTGGCTGGACCACGTGGACAGGATCCGGTCAGCAGCCCCTGTGGCTAGAGGAACACCAGCACAAACGACAGC
CTCAAGTCTCCTTCGAGCTTTATATCCATTTGGGGATGAAGTCTACTTTGACAGCTAGCAAGGCGACATGCAACTGTTGTTGAATGATGA
CAGCAATTCAGGAAAGACTTAAATATGAAAGCAAATTGAACACATCGGGTGTTTGTTATCAGAAAAGAGATGAGATGAGATAAGACTTGT
TTATTGACTAGCCAATATGTCATTAAAATTAAGGTTTATATTGTGAAGCTTTTTTGAAATTTTACTTTTTTTTGAGAGTTTTGCTCTGTC
ACCCAGGCTGGAGTGAGGTGGTACAATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGAGATTCTCCTGCCTCAGTCTCCCGAGT
AGCTAGGATTACAGATGTGCATCACCATGCCTGGCTAATTTTTGTATTTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGCTGGTC
TCGAACTCCTGACCTCAAGTGACCCGCCCTTGTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATTGTGCCCAGCCTATATAGT
GTGAAGCTTTTAGGAAAATCAGAACAGGGTAGACAGCTGTTAAAAACAATGTTTAAATGGAATAATGTTGAATGTTTACAGGCTGTAAGA
ACTATTGTATACACAAAATAATACACAAAGTTTGTACTTTGTGTACAAATACAAATTTGTACTTTGTGTACAAATAATACAAAAAGTTTG
TATACACAAACTTTTTACGTTGTGGTTTGGTATATTGTCTTAACTGAATTTTCTTATAAGAACCCCATGAAACTTACCTGAGTTTTTAAA
ATGCTATCCAGGACATCATACCTTATAGTATACATGAAACATAATGTAATCCAGGTTGTAATTTAGAACTTTTTTTTTTTTTTTAGCTGA
GCACTTAATGTAATTAATTCCAGGTTATGACTCTTAAAAAACATTGGCCATTAGAGAAATAGTTCTATTTGCCCATCCAAATCACCTGAA
TGACTTTTTGAAAGAATAGGGGTCCACATCCCCAGATCCCATCCCAGCTGTGCACAGTCTGAAGCAAGCAGAGTGAAACAAGTTGGCAAC
TTGTTCCAAGCGTGGGCCTTTGCAGTCTGTGATCCAGTGTTACTCCAGGTCCCAGTCTGTCCCATACTTGTCTTTTGCTACAGTTAGTTA
GTTACTTTGTTATCATCCCCTTGTAAACTGCCTTCAATATCTGGGATAAGGAAGACAAAGCTTAATGACAACTAAGGTTCTAGCTGACAT
CTTTCTTTCATATTTAATTTTTGTGAGTTTTCATCTGTTTTCTGTTTGTTTATGTGTCCTAGGTTCTTGACCTAACCACATGGGTTTTGT
TTTTTGTTTTTATATTAGAACTTAGAAAAGTTTGTTTTACAGCAGTATTATGGAACAGAAGAGACCATTTTAAATAATTTTTTTAAACAG
CCCAAAACACACAAAAGATACTTGTTTTCTAGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACGATCATAGCTCAGT
GCAGCCTCCACCTCCTGGGCTCAAGTGGTCCTCCTGCCTCAGCCTCTTAAGCAGTTGGGACTACAGGTGTGTGCCAGCATGCTTGCTGTT
TTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCACTCAGGCTGGAGTCCAGTGGCTTGGTCTCAGCTCACTGCAATCTCTGCCTCCCAGG
GGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGAAACTACAGGCGCATGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTA
GAGACAGGGTTTCACTATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAAGTGATCCGCCCGCTTCGGCCTCCCAAAGTGCTGGGATT
ACAGGTGTGAGCCACTGCGCCTGGCTGCTGATTTATTTTTCATAGACACGGGGGTCTATGTTGCCCAGGTTGGTCTTGAACTCCTAGCCT
CAAGCGATCCTCCTGCCTCAGCCTCCCAATGTGCTGGGATTACAGGAATGAGCCACCATGCCCAGCCCAAGAAGTAGAGTTTCTTTTATA
CTGACTTTGGCCTAAAAAAACAGATTTTCATGGAGGAAAAAAAAACCTAGATTTTTAGTAAGACTATTTTATATACTTTTTTACATTGAT
CAAGTACATTATTTTTACCAAACAACATTGTTTCCCACTACATCCATGGTTATGTATAAAAAAACGCCATTGTCAATTAAGATGTTAAAA
AATTATTTCCATAAGAGTATTAAATTCTAATCTATGATTCACTTAACTTCCTACTTTATAAACACTAGGTAAAGTAATCTCACAAGCTGC
CAAAGAACACATCCCAAGCAGTAATCACAGACGATGAAGCACCTTACAGGACCCCTCCACCCTCAAACGCGCATGTCCAGAGAAGTATTA
ATGCCTTAATAGACTACTGAAGGTTAACTATTTACATCATTCTAAAAATATTTTAAGCTGTATTACAGTGCTATAAATTCTCCTTTTAAG
GAAAAAAGTAATAGATTGTTTCCTTACCGTGTTTGAAAGGAAAAAAAATAAATCCATAGTAACTAATGGTCTGCCGATTTTTTCCCTGAA
TTTTTAAACTCCAACAAAGCATTATTTTGCAAAAAGTCCTTTAGCCCAAAGTCAGTGTCTCTGTTTTGATCTCTTTGTAAAAGAACTCTC
TGTTCATCCATTCTCTTTCCCTGGGACCGTAAAATAAGGCTGAAAAAGTCTTCATCTGGTACTGTCGGACCCTTTGTGGTAGCAGGTGGT
GGAGCACATCTTTGATCATCTAATCTGGATCCCTAGAAGTTTATGAGAGAGATTAAAAGACATACTGTGGGAAAGAAAGCACCAAGCTAT
GTTAAATCTCTCAGTCACAACAAGAAAACGCAGTTGTAAACTTTTATTTGGGGCTTCTCAGAAATTAATCTTTGTTTTTATATTGTTCTC

>12961_12961_4_CAPZA1-CLCC1_CAPZA1_chr1_113162505_ENST00000263168_CLCC1_chr1_109490340_ENST00000369971_length(amino acids)=525AA_BP=51
MVGVSGRVLPTAAAVIPSLGFLPGLPRARSRAGPEQPKMADFDDRVSDEEKIDECEKKKREDYESQSNPVFRRYLNKILIEAGKLGLPDE
NKGDMHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINFKFHDFETWKWRFEDSFGVDPYNVLMVLLCLLCIVVLVATELWTY
VRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQHQAEVAKMEPLNNVCAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPP
TKALAVTFTTFVTEPLKHIGKGTGEFIKALMKEIPALLHLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEID
YRPDGGAGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGG

--------------------------------------------------------------
>12961_12961_5_CAPZA1-CLCC1_CAPZA1_chr1_113162505_ENST00000263168_CLCC1_chr1_109490340_ENST00000369976_length(transcript)=2686nt_BP=711nt
GGGAATCCTGGGATAGTGGCGGACCTGAAGTTGGCCTCTGTGAAGGCTGAGTCCTGGGGAACCGGGACCGAGAAGATTTCGAAGGTGGAG
GAGCGTGTCTCAAGATTGGGGCTACCTGTTCTTTCGTGGGGCAGGGAAGGGGCGGACAGCAGCGCCTATTCTGGAGGAACTGGACTGAGA
TGTGACCCCGAAGTGTTACCGCTTCCAAACGAAATGAGGGTCACCTTTCACACCGCCCCCCCCCCGGGGTTGGAAAAGCCACCGATCGTT
CCAGCTGCCGAGCAGCTCTTAAAGCTTTGGATTCGGCTGTCGTGGAGATAACGGGCACCAGAAAAACTTGTAGGAGTAGCAACAGCTATT
TGGTCGGATGGAGGCCAGAAGCCAAGAATAATCGAAACACGCTGCCAGCGCCCATTAGATGGATGGGAAATGAGTGTAACTCATTGGGAA
AGATATTAGACTTCAAATCACCTAAGGCAAACCCTACTTCCTGGGGCGCGGGCGCGGGCGCTGGCGTTAGGAGACGTCACTCCCGCGCAT
AACTGACATGGGGCCCTCTTGGTCGGCGTTTCCGGGCGGGTCCTTCCGACGGCCGCCGCGGTGATTCCATCACTCGGCTTTCTTCCCGGC
CTGCCTCGCGCCCGTAGCCGGGCTGGGCCAGAACAGCCCAAGATGGCCGACTTCGATGATCGTGTGTCGGATGAGGAGAAGATTGATGAG
TGTGAAAAGAAAAAGAGGGAAGACTATGAAAGTCAAAGCAATCCTGTTTTTAGGAGATACTTAAATAAGATTTTAATTGAAGCTGGAAAG
CTTGGACTTCCTGATGAAAACAAAGGCGATATGCATTATGATGCTGAGATTATCCTTAAAAGAGAAACTTTGTTAGAAATACAGAAGTTT
CTCAATGGAGAAGACTGGAAACCAGGTGCCTTGGATGATGCACTAAGTGATATTTTAATTAATTTTAAGTTTCATGATTTTGAAACATGG
AAGTGGCGATTCGAAGATTCCTTTGGAGTGGATCCATATAATGTGTTAATGGTACTTCTTTGTCTGCTCTGCATCGTGGTTTTAGTGGCT
ACTGAGCTGTGGACATATGTACGTTGGTACACTCAGTTGAGACGTGTTTTAATCATCAGCTGTGCACAGTCTGAAGCAAGCAGAGTGAAA
CAAGTTGGCAACTTGTTCCAAGCGTGGGCCTTTGCAGTCTGTGATCCAGTGTTACTCCAGGTCCCAGTCTGTCCCATACTTGTCTTTTGC
TACAGTTAGTTAGTTACTTTGTTATCATCCCCTTGTAAACTGCCTTCAATATCTGGGATAAGGAAGACAAAGCTTAATGACAACTAAGGT
TCTAGCTGACATCTTTCTTTCATATTTAATTTTTGTGAGTTTTCATCTGTTTTCTGTTTGTTTATGTGTCCTAGGTTCTTGACCTAACCA
CATGGGTTTTGTTTTTTGTTTTTATATTAGAACTTAGAAAAGTTTGTTTTACAGCAGTATTATGGAACAGAAGAGACCATTTTAAATAAT
TTTTTTAAACAGCCCAAAACACACAAAAGATACTTGTTTTCTAGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACGA
TCATAGCTCAGTGCAGCCTCCACCTCCTGGGCTCAAGTGGTCCTCCTGCCTCAGCCTCTTAAGCAGTTGGGACTACAGGTGTGTGCCAGC
ATGCTTGCTGTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCACTCAGGCTGGAGTCCAGTGGCTTGGTCTCAGCTCACTGCAATCT
CTGCCTCCCAGGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGAAACTACAGGCGCATGCCACCATGCCCAGCTAATTTTT
GTATTTTTAGTAGAGACAGGGTTTCACTATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAAGTGATCCGCCCGCTTCGGCCTCCCAA
AGTGCTGGGATTACAGGTGTGAGCCACTGCGCCTGGCTGCTGATTTATTTTTCATAGACACGGGGGTCTATGTTGCCCAGGTTGGTCTTG
AACTCCTAGCCTCAAGCGATCCTCCTGCCTCAGCCTCCCAATGTGCTGGGATTACAGGAATGAGCCACCATGCCCAGCCCAAGAAGTAGA
GTTTCTTTTATACTGACTTTGGCCTAAAAAAACAGATTTTCATGGAGGAAAAAAAAACCTAGATTTTTAGTAAGACTATTTTATATACTT
TTTTACATTGATCAAGTACATTATTTTTACCAAACAACATTGTTTCCCACTACATCCATGGTTATGTATAAAAAAACGCCATTGTCAATT
AAGATGTTAAAAAATTATTTCCATAAGAGTATTAAATTCTAATCTATGATTCACTTAACTTCCTACTTTATAAACACTAGGTAAAGTAAT
CTCACAAGCTGCCAAAGAACACATCCCAAGCAGTAATCACAGACGATGAAGCACCTTACAGGACCCCTCCACCCTCAAACGCGCATGTCC
AGAGAAGTATTAATGCCTTAATAGACTACTGAAGGTTAACTATTTACATCATTCTAAAAATATTTTAAGCTGTATTACAGTGCTATAAAT

>12961_12961_5_CAPZA1-CLCC1_CAPZA1_chr1_113162505_ENST00000263168_CLCC1_chr1_109490340_ENST00000369976_length(amino acids)=236AA_BP=51
MVGVSGRVLPTAAAVIPSLGFLPGLPRARSRAGPEQPKMADFDDRVSDEEKIDECEKKKREDYESQSNPVFRRYLNKILIEAGKLGLPDE
NKGDMHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINFKFHDFETWKWRFEDSFGVDPYNVLMVLLCLLCIVVLVATELWTY

--------------------------------------------------------------
>12961_12961_6_CAPZA1-CLCC1_CAPZA1_chr1_113162505_ENST00000263168_CLCC1_chr1_109490340_ENST00000415331_length(transcript)=5025nt_BP=711nt
GGGAATCCTGGGATAGTGGCGGACCTGAAGTTGGCCTCTGTGAAGGCTGAGTCCTGGGGAACCGGGACCGAGAAGATTTCGAAGGTGGAG
GAGCGTGTCTCAAGATTGGGGCTACCTGTTCTTTCGTGGGGCAGGGAAGGGGCGGACAGCAGCGCCTATTCTGGAGGAACTGGACTGAGA
TGTGACCCCGAAGTGTTACCGCTTCCAAACGAAATGAGGGTCACCTTTCACACCGCCCCCCCCCCGGGGTTGGAAAAGCCACCGATCGTT
CCAGCTGCCGAGCAGCTCTTAAAGCTTTGGATTCGGCTGTCGTGGAGATAACGGGCACCAGAAAAACTTGTAGGAGTAGCAACAGCTATT
TGGTCGGATGGAGGCCAGAAGCCAAGAATAATCGAAACACGCTGCCAGCGCCCATTAGATGGATGGGAAATGAGTGTAACTCATTGGGAA
AGATATTAGACTTCAAATCACCTAAGGCAAACCCTACTTCCTGGGGCGCGGGCGCGGGCGCTGGCGTTAGGAGACGTCACTCCCGCGCAT
AACTGACATGGGGCCCTCTTGGTCGGCGTTTCCGGGCGGGTCCTTCCGACGGCCGCCGCGGTGATTCCATCACTCGGCTTTCTTCCCGGC
CTGCCTCGCGCCCGTAGCCGGGCTGGGCCAGAACAGCCCAAGATGGCCGACTTCGATGATCGTGTGTCGGATGAGGAGAAGATTGATGAG
TGTGAAAAGAAAAAGAGGGAAGACTATGAAAGTCAAAGCAATCCTGTTTTTAGGAGATACTTAAATAAGATTTTAATTGAAGCTGGAAAG
CTTGGACTTTTTCATGATTTTGAAACATGGAAGTGGCGATTCGAAGATTCCTTTGGAGTGGATCCATATAATGTGTTAATGGTACTTCTT
TGTCTGCTCTGCATCGTGGTTTTAGTGGCTACTGAGCTGTGGACATATGTACGTTGGTACACTCAGTTGAGACGTGTTTTAATCATCAGC
TTTCTGTTCAGTTTGGGATGGAATTGGATGTATTTATATAAGCTAGCTTTTGCACAGCATCAGGCTGAAGTCGCCAAGATGGAGCCATTA
AACAATGTGTGTGCCAAAAAGATGGACTGGACTGGAAGTATCTGGGAATGGTTTAGAAGTTCATGGACCTATAAGGATGACCCATGCCAA
AAATACTATGAGCTCTTACTAGTCAACCCTATTTGGTTGGTCCCACCAACAAAGGCACTTGCAGTTACATTCACCACATTTGTAACGGAG
CCATTGAAGCATATTGGAAAAGGAACTGGGGAATTTATTAAAGCACTCATGAAGGAAATTCCAGCGCTGCTTCATCTTCCAGTGCTGATA
ATTATGGCATTAGCCATCCTGAGTTTCTGCTATGGTGCTGGAAAATCAGTTCATGTGCTGAGACATATAGGCGGTCCTGAGAGCGAACCT
CCCCAGGCACTTCGGCCACGGGATAGAAGACGGCAGGAGGAAATTGATTATAGACCTGATGGTGGAGCAGGTGATGCCGATTTCCATTAT
AGGGGCCAAATGGGCCCCACTGAGCAAGGCCCTTATGCCAAAACGTATGAGGGTAGAAGAGAGATTTTGAGAGAGAGAGATGTTGACTTG
AGATTTCAGACTGGCAACAAGAGCCCTGAAGTGCTCCGGGCATTTGATGTACCAGACGCAGAGGCACGAGAGCATCCCACGGTGGTACCC
AGTCATAAATCACCTGTTTTGGATACAAAGCCCAAGGAGACAGGTGGAATCCTGGGGGAAGGCACACCGAAAGAAAGCAGTACTGAAAGC
AGCCAGTCGGCCAAGCCTGTCTCTGGCCAAGACACATCAGGGAATACAGAAGGTTCACCCGCAGCGGAAAAGGCCCAGCTCAAGTCTGAA
GCCGCAGGCAGCCCAGACCAAGGCAGCACATACAGCCCCGCAAGAGGTGTGGCTGGACCACGTGGACAGGATCCGGTCAGCAGCCCCTGT
GGCTAGAGGAACACCAGCACAAACGACAGCCTCAAGTCTCCTTCGAGCTTTATATCCATTTGGGGATGAAGTCTACTTTGACAGCTAGCA
AGGCGACATGCAACTGTTGTTGAATGATGACAGCAATTCAGGAAAGACTTAAATATGAAAGCAAATTGAACACATCGGGTGTTTGTTATC
AGAAAAGAGATGAGATGAGATAAGACTTGTTTATTGACTAGCCAATATGTCATTAAAATTAAGGTTTATATTGTGAAGCTTTTTTGAAAT
TTTACTTTTTTTTGAGAGTTTTGCTCTGTCACCCAGGCTGGAGTGAGGTGGTACAATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTC
AAGAGATTCTCCTGCCTCAGTCTCCCGAGTAGCTAGGATTACAGATGTGCATCACCATGCCTGGCTAATTTTTGTATTTTTTAGTAGAGA
TGGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAAGTGACCCGCCCTTGTCGGCCTCCCAAAGTGCTGGGATTACAG
GCATGAGCCATTGTGCCCAGCCTATATAGTGTGAAGCTTTTAGGAAAATCAGAACAGGGTAGACAGCTGTTAAAAACAATGTTTAAATGG
AATAATGTTGAATGTTTACAGGCTGTAAGAACTATTGTATACACAAAATAATACACAAAGTTTGTACTTTGTGTACAAATACAAATTTGT
ACTTTGTGTACAAATAATACAAAAAGTTTGTATACACAAACTTTTTACGTTGTGGTTTGGTATATTGTCTTAACTGAATTTTCTTATAAG
AACCCCATGAAACTTACCTGAGTTTTTAAAATGCTATCCAGGACATCATACCTTATAGTATACATGAAACATAATGTAATCCAGGTTGTA
ATTTAGAACTTTTTTTTTTTTTTTAGCTGAGCACTTAATGTAATTAATTCCAGGTTATGACTCTTAAAAAACATTGGCCATTAGAGAAAT
AGTTCTATTTGCCCATCCAAATCACCTGAATGACTTTTTGAAAGAATAGGGGTCCACATCCCCAGATCCCATCCCAGCTGTGCACAGTCT
GAAGCAAGCAGAGTGAAACAAGTTGGCAACTTGTTCCAAGCGTGGGCCTTTGCAGTCTGTGATCCAGTGTTACTCCAGGTCCCAGTCTGT
CCCATACTTGTCTTTTGCTACAGTTAGTTAGTTACTTTGTTATCATCCCCTTGTAAACTGCCTTCAATATCTGGGATAAGGAAGACAAAG
CTTAATGACAACTAAGGTTCTAGCTGACATCTTTCTTTCATATTTAATTTTTGTGAGTTTTCATCTGTTTTCTGTTTGTTTATGTGTCCT
AGGTTCTTGACCTAACCACATGGGTTTTGTTTTTTGTTTTTATATTAGAACTTAGAAAAGTTTGTTTTACAGCAGTATTATGGAACAGAA
GAGACCATTTTAAATAATTTTTTTAAACAGCCCAAAACACACAAAAGATACTTGTTTTCTAGAGACAGGGTCTTGCTCTGTCACCCAGGC
TGGAGTGCAGTGGCACGATCATAGCTCAGTGCAGCCTCCACCTCCTGGGCTCAAGTGGTCCTCCTGCCTCAGCCTCTTAAGCAGTTGGGA
CTACAGGTGTGTGCCAGCATGCTTGCTGTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCACTCAGGCTGGAGTCCAGTGGCTTGGT
CTCAGCTCACTGCAATCTCTGCCTCCCAGGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGAAACTACAGGCGCATGCCAC
CATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAAGTGATCCG
CCCGCTTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCGCCTGGCTGCTGATTTATTTTTCATAGACACGGGGGTCTATG
TTGCCCAGGTTGGTCTTGAACTCCTAGCCTCAAGCGATCCTCCTGCCTCAGCCTCCCAATGTGCTGGGATTACAGGAATGAGCCACCATG
CCCAGCCCAAGAAGTAGAGTTTCTTTTATACTGACTTTGGCCTAAAAAAACAGATTTTCATGGAGGAAAAAAAAACCTAGATTTTTAGTA
AGACTATTTTATATACTTTTTTACATTGATCAAGTACATTATTTTTACCAAACAACATTGTTTCCCACTACATCCATGGTTATGTATAAA
AAAACGCCATTGTCAATTAAGATGTTAAAAAATTATTTCCATAAGAGTATTAAATTCTAATCTATGATTCACTTAACTTCCTACTTTATA
AACACTAGGTAAAGTAATCTCACAAGCTGCCAAAGAACACATCCCAAGCAGTAATCACAGACGATGAAGCACCTTACAGGACCCCTCCAC
CCTCAAACGCGCATGTCCAGAGAAGTATTAATGCCTTAATAGACTACTGAAGGTTAACTATTTACATCATTCTAAAAATATTTTAAGCTG
TATTACAGTGCTATAAATTCTCCTTTTAAGGAAAAAAGTAATAGATTGTTTCCTTACCGTGTTTGAAAGGAAAAAAAATAAATCCATAGT
AACTAATGGTCTGCCGATTTTTTCCCTGAATTTTTAAACTCCAACAAAGCATTATTTTGCAAAAAGTCCTTTAGCCCAAAGTCAGTGTCT
CTGTTTTGATCTCTTTGTAAAAGAACTCTCTGTTCATCCATTCTCTTTCCCTGGGACCGTAAAATAAGGCTGAAAAAGTCTTCATCTGGT
ACTGTCGGACCCTTTGTGGTAGCAGGTGGTGGAGCACATCTTTGATCATCTAATCTGGATCCCTAGAAGTTTATGAGAGAGATTAAAAGA
CATACTGTGGGAAAGAAAGCACCAAGCTATGTTAAATCTCTCAGTCACAACAAGAAAACGCAGTTGTAAACTTTTATTTGGGGCTTCTCA

>12961_12961_6_CAPZA1-CLCC1_CAPZA1_chr1_113162505_ENST00000263168_CLCC1_chr1_109490340_ENST00000415331_length(amino acids)=475AA_BP=51
MVGVSGRVLPTAAAVIPSLGFLPGLPRARSRAGPEQPKMADFDDRVSDEEKIDECEKKKREDYESQSNPVFRRYLNKILIEAGKLGLFHD
FETWKWRFEDSFGVDPYNVLMVLLCLLCIVVLVATELWTYVRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQHQAEVAKMEPLNNVCAK
KMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTTFVTEPLKHIGKGTGEFIKALMKEIPALLHLPVLIIMALAI
LSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGN
KSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQSAKPVSGQDTSGNTEGSPAAEKAQLKSEAAGSPD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CAPZA1-CLCC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAPZA1-CLCC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAPZA1-CLCC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCAPZA1C0279626Squamous cell carcinoma of esophagus1CTD_human