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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CAPZA1-CTTNBP2NL (FusionGDB2 ID:HG829TG55917)

Fusion Gene Summary for CAPZA1-CTTNBP2NL

Fusion gene summary

Fusion gene information	Fusion gene name: CAPZA1-CTTNBP2NL
	Fusion gene ID: hg829tg55917
		Hgene	Tgene
	Gene symbol	CAPZA1	CTTNBP2NL
	Gene ID	829	55917
	Gene name	capping actin protein of muscle Z-line subunit alpha 1	CTTNBP2 N-terminal like
	Synonyms	CAPPA1\|CAPZ\|CAZ1	-
	Cytomap	('CAPZA1')('CTTNBP2NL') 1p13.2	1p13.2
	Type of gene	protein-coding	protein-coding
	Description	F-actin-capping protein subunit alpha-1Cap ZcapZ alpha-1capping actin protein of muscle Z-line alpha subunit 1capping protein (actin filament) muscle Z-line, alpha 1	CTTNBP2 N-terminal-like protein
	Modification date	20200327	20200313
	UniProtAcc	P52907	.
	Ensembl transtripts involved in fusion gene	ENST00000476936, ENST00000263168,	ENST00000476936, ENST00000263168,
Fusion gene scores	* DoF score	15 X 8 X 7=840	6 X 5 X 3=90
	# samples	15	6
	** MAII score	log2(15/840*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CAPZA1 [Title/Abstract] AND CTTNBP2NL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CAPZA1(113202401)-CTTNBP2NL(112991564), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CAPZA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CTTNBP2NL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-1842-01A	CAPZA1	chr1	113202401	+	CTTNBP2NL	chr1	112991564	+

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Fusion Gene ORF analysis for CAPZA1-CTTNBP2NL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000476936	ENST00000271277	CAPZA1	chr1	113202401	+	CTTNBP2NL	chr1	112991564	+
3UTR-intron	ENST00000476936	ENST00000607039	CAPZA1	chr1	113202401	+	CTTNBP2NL	chr1	112991564	+
5CDS-intron	ENST00000263168	ENST00000607039	CAPZA1	chr1	113202401	+	CTTNBP2NL	chr1	112991564	+
In-frame	ENST00000263168	ENST00000271277	CAPZA1	chr1	113202401	+	CTTNBP2NL	chr1	112991564	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000263168

CAPZA1

chr1

113202401

ENST00000271277

CTTNBP2NL

chr1

112991564

6830

1257

558

3077

839

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000263168	ENST00000271277	CAPZA1	chr1	113202401	+	CTTNBP2NL	chr1	112991564	+	0.000866701	0.9991333

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Fusion Genomic Features for CAPZA1-CTTNBP2NL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CAPZA1	chr1	113202401	+	CTTNBP2NL	chr1	112991563	+	2.13E-08	1
CAPZA1	chr1	113202401	+	CTTNBP2NL	chr1	112991563	+	2.13E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CAPZA1-CTTNBP2NL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:113202401/chr1:112991564)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CAPZA1 P52907	.
FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. {ECO:0000269\|PubMed:22891260}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CTTNBP2NL

chr1:113202401

chr1:112991564

ENST00000271277

87_285

640.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CAPZA1-CTTNBP2NL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>12963_12963_1_CAPZA1-CTTNBP2NL_CAPZA1_chr1_113202401_ENST00000263168_CTTNBP2NL_chr1_112991564_ENST00000271277_length(transcript)=6830nt_BP=1257nt
GGGAATCCTGGGATAGTGGCGGACCTGAAGTTGGCCTCTGTGAAGGCTGAGTCCTGGGGAACCGGGACCGAGAAGATTTCGAAGGTGGAG
GAGCGTGTCTCAAGATTGGGGCTACCTGTTCTTTCGTGGGGCAGGGAAGGGGCGGACAGCAGCGCCTATTCTGGAGGAACTGGACTGAGA
TGTGACCCCGAAGTGTTACCGCTTCCAAACGAAATGAGGGTCACCTTTCACACCGCCCCCCCCCCGGGGTTGGAAAAGCCACCGATCGTT
CCAGCTGCCGAGCAGCTCTTAAAGCTTTGGATTCGGCTGTCGTGGAGATAACGGGCACCAGAAAAACTTGTAGGAGTAGCAACAGCTATT
TGGTCGGATGGAGGCCAGAAGCCAAGAATAATCGAAACACGCTGCCAGCGCCCATTAGATGGATGGGAAATGAGTGTAACTCATTGGGAA
AGATATTAGACTTCAAATCACCTAAGGCAAACCCTACTTCCTGGGGCGCGGGCGCGGGCGCTGGCGTTAGGAGACGTCACTCCCGCGCAT
AACTGACATGGGGCCCTCTTGGTCGGCGTTTCCGGGCGGGTCCTTCCGACGGCCGCCGCGGTGATTCCATCACTCGGCTTTCTTCCCGGC
CTGCCTCGCGCCCGTAGCCGGGCTGGGCCAGAACAGCCCAAGATGGCCGACTTCGATGATCGTGTGTCGGATGAGGAGAAGGTACGCATA
GCTGCTAAATTCATCACTCATGCACCCCCAGGGGAATTTAATGAAGTATTCAATGACGTTCGGCTACTACTTAATAATGACAATCTCCTC
AGGGAAGGGGCAGCACATGCATTTGCCCAGTATAACATGGATCAGTTCACGCCTGTGAAGATAGAAGGATATGAAGATCAGGTCTTAATT
ACAGAGCACGGTGACCTGGGTAATAGCAGATTTTTAGATCCAAGAAACAAAATTTCCTTTAAATTTGACCACTTACGGAAAGAAGCAAGT
GACCCCCAGCCAGAAGAAGCAGATGGAGGTCTGAAGTCTTGGAGAGAATCCTGTGACAGTGCTTTAAGAGCCTATGTGAAAGACCATTAT
TCCAACGGCTTCTGTACTGTTTATGCTAAAACTATCGATGGGCAACAGACTATTATTGCATGTATTGAAAGCCACCAGTTTCAGCCTAAA
AACTTCTGGAATGGTCGTTGGAGATCAGAGTGGAAGTTCACCATCACACCACCTACAGCCCAGGTGGTTGGCGTGCTTAAGATTCAGGCC
CAACACAGAGATACTTTCATTGAAGAACGCTATGGAAAATATAACATCAGTGATCCTTTAATGGCTCTACAGAGAGATTTTGAAACACTG
AAGGAGAAAAATGATGGCGAAAAGCAGCCAGTCTGCACAAATCCACTCTCTATTCTTAAGGTTGTGATGAAGCAGTGCAAGAACATGCAG
GAGCGCATGCTGTCCCAGCTGGCTGCTGCTGAGAGCAGGCACCGAAAGGTGATCCTAGACCTTGAGGAAGAAAGGCAGCGGCATGCACAG
GATACGGCTGAAGGAGATGATGTCACCTACATGCTAGAGAAGGAAAGAGAGAGGCTGACTCAACAGTTGGAATTTGAAAAATCCCAAGTG
AAAAAGTTTGAAAAAGAACAGAAGAAGCTCTCTAGTCAGCTGGAAGAGGAGCGCTCCCGCCACAAGCAGCTCTCATCCATGCTAGTGCTT
GAGTGCAAGAAAGCCACCAACAAGGCAGCCGAGGAAGGACAGAAGGCAGGAGAGCTGAGCCTGAAATTGGAGAAGGAGAAGAGCCGGGTG
AGTAAACTGGAAGAAGAGTTGGCAGCTGAGAGAAAGAGAGGCTTGCAGACTGAGGCCCAGGTAGAGAAGCAGTTATCAGAGTTTGACATC
GAAAGGGAACAACTGAGAGCAAAACTGAACCGAGAAGAGAACCGGACCAAAACCCTGAAAGAAGAAATGGAAAGTTTAAAGAAGATAGTG
AAGGACCTAGAGGCTTCCCACCAGCACAGTAGCCCTAATGAGCAATTGAAGAAACCAGTAACCGTGTCCAAAGGCACAGCAACTGAGCCT
CTCATGCTAATGTCTGTGTTTTGCCAAACAGAGAGTTTTCCAGCAGAAAGAACCCATGGGAGCAACATAGCCAAGATGACAAACACTGGG
CTGCCTGGTCCTGCCACTCCTGCTTACTCATATGCAAAAACCAATGGCCATTGTGACCCAGAGATACAAACTACCAGGGAGCTGACTGCA
GGCAACAATGTAGAAAACCAGGTGCCTCCACGGGAAAAATCTGTGGCATTGGCCCAAGAGAAACCAGTGGAGAATGGTGGGTGTCCTGTG
GGGATTGAGACTCCAGTCCCAATGCCCAGTCCCCTCTCTTCCAGTGGGAGCTCACTGTCTCCCAGCAGCACTGCCTCCTCCTCTCTAACA
TCCTCTCCTTGCTCTTCGCCGGTACTCACTAAGCGTTTATTGGGGTCATCAGCTAGCAGCCCTGGCTACCAGTCATCGTACCAAGTAGGG
ATCAACCAACGGTTCCATGCAGCTCGCCACAAATTTCAGTCCCAAGCAGATCAGGACCAACAAGCCAGTGGCCTACAGAGCCCTCCATCC
AGGGATTTATCCCCCACCCTCATAGACAACTCTGCCGCCAAGCAGCTGGCCCGAAACACAGTCACTCAGGTGCTCTCCAGATTCACTAGC
CAACAAGGGCCAATCAAGCCAGTCTCTCCCAACAGCTCTCCCTTTGGCACAGACTATCGAAATCTAGCCAACACTGCCAATCCAAGAGGT
GACACAAGCCATTCACCTACTCCAGGGAAAGTGTCCAGTCCCCTGAGCCCCCTGTCTCCAGGAATCAAGTCCCCAACCATCCCCAGAGCT
GAGAGAGGAAACCCTCCACCCATCCCACCCAAGAAACCTGGCCTCACCCCTTCTCCATCTGCTACCACTCCATTGACCAAAACTCATTCC
CAGGCAGCCTCTTTGACCACTGCAGAAGACCTTGCCAGCAGCTGCTCTTCCAATACTGTTGTAGCAAATGGTAAGGATGTTGAGTTACTT
TTGCCTACCAGCAGCTAGTCCCTAGGAGGGAGTCTCCACGTTTGACATTCCATCAGATTTCGTCCAAAAGCTCAGTCAGACTTCTGAGTC
AGATTATGTTATTTATTTTGATAGTAGCTGAAACCATCTGTATAATACATTTAGTATATTTCACCATTTTGTATTTTTTTAAGTAGAAAC
TGAGTAGTTTGGATTTTTATGGCTCACATCTTTTTACTGAAGCCAGAAAGGCACCTCAAAGATGTCTCAAGCTCAGCAGTCACCGTCATG
TTGTGATGAAGAAAGCGAATCACCAGGTGGTGATTTGCTATCTATTTGAGAACTAGAATCACTCAACACTCATTTTGAATTATGCAGAAG
TGGTTCATGCAGATTTTTATTCCAGATGAACATGTTTTAAAAGTGCCTGAAATATGACTGCCATATGAATGTGATTCTGCAGCAAAAAAC
ACAAAATAGATCATTTAATTACAGAAAATGAGATCCTCTGTGAATTCTGAATGTTAAAAACCAACACTGCTTTTAATCCTCTTTTAATGT
TTTAATACAAGCTTTGTGTTCTGAAACAAGGCTGCATAAGTAGAATGGGAATCCTTCTAAAGGTGGGTGTGAACTCACCACAAGCTGAGC
TTTATAGAGCCCTTGAGAAACCCTCCTGAGCACTAAGCAGTTGGGGTGCTGATTTTCTTGTACTTTTGAAAAATTAAGTCACTCCCAGTT
TCCTGCATAAGTTCTTGAACAGAATGAAATCACATCTCCATTCAAAAAATGTCTCAAGCATCTACTGTTGTGTAAGGAACTTCTGATTCT
GATTGCTGTTACTTGAATAGGAAATGGTTACTCATTCTGTATAAAAGTTTTGCAAGAGAATGAATTTTTTATTCTGTAATCAAAAAGCAA
TAACTTGAAATTCACTCTGTAATATTATAGGTCAGTCAGAATTATACAAGTTTTACCAAATTGTTACACTTATTCTCCAAGCTGCCAGAA
CCTGGTATCTGTATCTGTAAAACCAAATTAACTTTTGCTTAAATGGGAAGTATACATATATCTGTATAGATACATTACCCCTTTACATGT
TTAACATACACACACTTAAACACATAAATACTAGTGTGATTATATCTTTGGAGTTTGCAATATAGCATAAAGGACAAGTAGAACTGCACA
TTAAGATTACCTACCGAAGCAACTAGATGTGGCTGGGACACAATCAAAGGAGGAATTTTGTCCACAGGAAGGTGAGGAAATTCCAAATGA
AGCCTAGATCTTCAGTATCATAAAAAGGCAGAGCTGGCCAGGCACAGTGGCTCATGCCTGTAATCTTATCACTTTGGGAGGCTGAGATGG
GAGGATCTCTTGAGACCAGGTGTTCAAGACCAGCCTCATCAACATAGTGAGACCCCATCTCTATTAAAAAAATAAATAGGCAGAGCTAAA
CTAACCCCAGTGTCACAAAACTCAACTGGTCATATAAATGAGTGAAACAGGCCTCTCACACAAGCGATGTAAAACAGCTGGGAGCAGTGG
GAGCTGTGGCAAACTAAAGTGCCCAAGCCGCATTTAAAAAGGGCATCTGTTCAGCTCCATCTGCTTGCTGCGGTGCAAGAATGCTAAACC
AGGATTACCAGTTCTTCACATTTTTTGAAATCCAAATTTTCATGAGAAACATTCTCATTTTTAAATATCAAGAAGTGATTTTAAAATGTT
TAAATGGTGCTGGTTAAACAAACACGTCTGCAGCTGGATTTAGCTTGCAAGCTGCCAAGTTGCAACCTCTTTCATTCTAGAAACTTCTGT
CATTTTCATCATAGCAAGTCTATGCGGACAAAAGCCTCCAAACTTTCCAACTGTGTAGGCCAGTACAGCTGGCAAGGTTCATAGAATATA
ATGGCTATCCCCCTCTGCCAAATAAGACTATCCACAACCCAGCTCAGACACAGTGGTTATATGATTTTGTGTCCATACAGGAGAGGCCTT
GGTGTCTTCACATACATTCTCTGAGCCAACATCTATCCAGCAGCCCTGACCTCCTGCTATAATTTAAGTCTATTTCCTTTTAATCTAATA
AGAGTTGATAGTAAAAAGGCAGGTGATGGAAATCAGTGTATAAATCACAATGGAGTATATTGGCAACTCCACAGCTTATAGTTTGATAAA
GGCAAATACATGAAAAATAAAAATGCTACTAATGCCCCAAGGTGTCTATCAAAATGATGTAGGGGGTATCTTAAACTGTCCAAGGCAATC
ATGCATTGAACTTTATTCCTATGCAGAGCCAAAACGAATAGTGTTGATAAAATAGCTAAACTTTCTAAACTGGAGAGGAGGCTACAGTGC
CAGAGAGTTATTGTCTCTTTTGCTTTAAATGGTAATCTTAAAAGTTGCATTGTGCTCTTCCTTTGTTTTGGGATAGATATATATAGAGAG
AGATACTATAAGGAAGTTTATTTCTTAGGAAGTGCACTGAATAATGTATTTCTTTTACAGTGTAATATGGGGGTGGGGATATGCGAAAGA
AATGTGTATTTTTGCTAGTTGCCTACCTTCTGAGATAAATAAGCACAATCTTGCAATGGATCCAATAACCCAGTTAGGTATTATAGATTA
GTATTTAAGTTTGCTGTAGATTGTGTGTGTGTGTGCTAAGTAAAAGTTCCATGATTCACAATTTTAGTATTAACCCATGTTGCAAAAGCT
GTTACTGGCCAACAGATTGTAATGATGTGTACCATATAACACAAGCATTAACTAGGCATTAACGTTTGTAAAGCCAAATATACCATGCAG
AAGTCTTCATTTTTATAGCAGACTGCATTAAAACAAGTTAAATCTTGCTGTTTGGGGGGAAATAGTCTTGTTTGTACAAAGTGAAAAATG
GCACAATTTGGGCATATTTTGTTGGGAAGAGGGGGTGGTGTAGAGGGAGCACTTGACTGTGGCTTTGACAAAACAAATGAAGTCAATGAC
CCATCCAGGTTAGACTCCATAAGGAACTAAGACATTGATTTTCTTTAGAGTCTTAGAGCTGGAAAAAGCCTTTACAATAATCCAGTCTGT
GATTTTTTAAACCTTTTGGTGGTTCTGGACCTTTTTGAGAATCTTAGAAAAGCCATGGAGTTTATCCCTAGAAAAATGAATATGCCTATA
TGCAAAATTTGTTTGATGGCTTCATAGGATCCAAAGACCCTGAAGCCATCCATGGCTCATGTATTTCTGCTTAAGAAAGCATAATCTTGT
TCTGCTCTCTCATTTTACAAATGATTAATGCATCCCTTTTCAACTACTCCAGCGCTGTTGCTGCTGCAATGTTAGCAAATGCAAGCCAGA
GAGAAGCACTTGAAAATCCTTTGATGTCTAAAAAATGTTCAAATAGTGTGGATGTTTACATATCTGAAGTTTTCAGCATTTAAGCAAATT
AATGATCATTTCAACAAATACTAGCATATCCGGTTTCCCTTAATAGCCTGTCAGCAGTGCTGCCTTGTCAATTTGTGTGTGTGTGTGTGT
ATGTGTGTGTGTGTGTGAATTCATAAGGAGTGCTTCTGATGCTTAGTCCTTGAAATGGAACTTCAACTGTCTTTCAAAACACTGGCTTCA
AAATAGGATGTGTTTTCCTAATGAATCAGAAGTGGGCAATGAGCATTGTTCCACAGGAATAATTTTTAATTTAATTTCTATAAAACTAGT

>12963_12963_1_CAPZA1-CTTNBP2NL_CAPZA1_chr1_113202401_ENST00000263168_CTTNBP2NL_chr1_112991564_ENST00000271277_length(amino acids)=839AA_BP=232
MVGVSGRVLPTAAAVIPSLGFLPGLPRARSRAGPEQPKMADFDDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAH
AFAQYNMDQFTPVKIEGYEDQVLITEHGDLGNSRFLDPRNKISFKFDHLRKEASDPQPEEADGGLKSWRESCDSALRAYVKDHYSNGFCT
VYAKTIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFTITPPTAQVVGVLKIQAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDG
EKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKE
QKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLR
AKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPLMLMSVFCQTESFPAERTHGSNIAKMTNTGLPGPAT
PAYSYAKTNGHCDPEIQTTRELTAGNNVENQVPPREKSVALAQEKPVENGGCPVGIETPVPMPSPLSSSGSSLSPSSTASSSLTSSPCSS
PVLTKRLLGSSASSPGYQSSYQVGINQRFHAARHKFQSQADQDQQASGLQSPPSRDLSPTLIDNSAAKQLARNTVTQVLSRFTSQQGPIK
PVSPNSSPFGTDYRNLANTANPRGDTSHSPTPGKVSSPLSPLSPGIKSPTIPRAERGNPPPIPPKKPGLTPSPSATTPLTKTHSQAASLT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CAPZA1-CTTNBP2NL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CAPZA1-CTTNBP2NL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CAPZA1-CTTNBP2NL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CAPZA1	C0279626	Squamous cell carcinoma of esophagus	1	CTD_human
Tgene		C0023893	Liver Cirrhosis, Experimental	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:CAPZA1-CTTNBP2NL (FusionGDB2 ID:HG829TG55917)

Fusion Gene Summary for CAPZA1-CTTNBP2NL

Fusion Gene ORF analysis for CAPZA1-CTTNBP2NL

Fusion Genomic Features for CAPZA1-CTTNBP2NL

Fusion Protein Features for CAPZA1-CTTNBP2NL

Fusion Gene Sequence for CAPZA1-CTTNBP2NL

Fusion Gene PPI Analysis for CAPZA1-CTTNBP2NL

Related Drugs for CAPZA1-CTTNBP2NL

Related Diseases for CAPZA1-CTTNBP2NL

Fusion Gene Studies
in Kim Lab