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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AXIN1-MYO19 (FusionGDB2 ID:HG8312TG80179)

Fusion Gene Summary for AXIN1-MYO19

check button Fusion gene summary
Fusion gene informationFusion gene name: AXIN1-MYO19
Fusion gene ID: hg8312tg80179
HgeneTgene
Gene symbol

AXIN1

MYO19

Gene ID

8312

80179

Gene nameaxin 1myosin XIX
SynonymsAXIN|PPP1R49MYOHD1
Cytomap('AXIN1')('MYO19')

16p13.3

17q12

Type of geneprotein-codingprotein-coding
Descriptionaxin-1axis inhibition protein 1axis inhibitor 1fused, mouse, homolog ofprotein phosphatase 1, regulatory subunit 49unconventional myosin-XIXmyosin head domain containing 1myosin head domain-containing protein 1
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262320, ENST00000354866, 
ENST00000481769, 
Fusion gene scores* DoF score16 X 10 X 9=14408 X 9 X 5=360
# samples 2310
** MAII scorelog2(23/1440*10)=-2.6463630453853
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AXIN1 [Title/Abstract] AND MYO19 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAXIN1(354304)-MYO19(34867294), # samples:1
Anticipated loss of major functional domain due to fusion event.AXIN1-MYO19 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AXIN1-MYO19 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AXIN1-MYO19 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AXIN1-MYO19 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAXIN1

GO:0001934

positive regulation of protein phosphorylation

9601641

HgeneAXIN1

GO:0032147

activation of protein kinase activity

9601641

HgeneAXIN1

GO:0034622

cellular protein-containing complex assembly

16601693

HgeneAXIN1

GO:0045732

positive regulation of protein catabolic process

9601641

HgeneAXIN1

GO:0090090

negative regulation of canonical Wnt signaling pathway

10644691

TgeneMYO19

GO:0034642

mitochondrion migration along actin filament

19932026


check buttonFusion gene breakpoints across AXIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MYO19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8296-01AAXIN1chr16

354304

-MYO19chr17

34867294

-


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Fusion Gene ORF analysis for AXIN1-MYO19

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262320ENST00000544606AXIN1chr16

354304

-MYO19chr17

34867294

-
5CDS-intronENST00000262320ENST00000586007AXIN1chr16

354304

-MYO19chr17

34867294

-
5CDS-intronENST00000262320ENST00000590081AXIN1chr16

354304

-MYO19chr17

34867294

-
5CDS-intronENST00000354866ENST00000544606AXIN1chr16

354304

-MYO19chr17

34867294

-
5CDS-intronENST00000354866ENST00000586007AXIN1chr16

354304

-MYO19chr17

34867294

-
5CDS-intronENST00000354866ENST00000590081AXIN1chr16

354304

-MYO19chr17

34867294

-
5UTR-3CDSENST00000481769ENST00000268852AXIN1chr16

354304

-MYO19chr17

34867294

-
5UTR-3CDSENST00000481769ENST00000431794AXIN1chr16

354304

-MYO19chr17

34867294

-
5UTR-intronENST00000481769ENST00000544606AXIN1chr16

354304

-MYO19chr17

34867294

-
5UTR-intronENST00000481769ENST00000586007AXIN1chr16

354304

-MYO19chr17

34867294

-
5UTR-intronENST00000481769ENST00000590081AXIN1chr16

354304

-MYO19chr17

34867294

-
In-frameENST00000262320ENST00000268852AXIN1chr16

354304

-MYO19chr17

34867294

-
In-frameENST00000262320ENST00000431794AXIN1chr16

354304

-MYO19chr17

34867294

-
In-frameENST00000354866ENST00000268852AXIN1chr16

354304

-MYO19chr17

34867294

-
In-frameENST00000354866ENST00000431794AXIN1chr16

354304

-MYO19chr17

34867294

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262320AXIN1chr16354304-ENST00000431794MYO19chr1734867294-426316262136441207
ENST00000262320AXIN1chr16354304-ENST00000268852MYO19chr1734867294-354116262130441007
ENST00000354866AXIN1chr16354304-ENST00000431794MYO19chr1734867294-405314161534341139
ENST00000354866AXIN1chr16354304-ENST00000268852MYO19chr1734867294-33311416152834939

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262320ENST00000431794AXIN1chr16354304-MYO19chr1734867294-0.0061666860.9938333
ENST00000262320ENST00000268852AXIN1chr16354304-MYO19chr1734867294-0.0075602930.99243975
ENST00000354866ENST00000431794AXIN1chr16354304-MYO19chr1734867294-0.0045536490.99544626
ENST00000354866ENST00000268852AXIN1chr16354304-MYO19chr1734867294-0.0068186790.9931813

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Fusion Genomic Features for AXIN1-MYO19


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AXIN1-MYO19


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:354304/chr17:34867294)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAXIN1chr16:354304chr17:34867294ENST00000262320-51188_211418863.0DomainRGS
HgeneAXIN1chr16:354304chr17:34867294ENST00000354866-51088_211418827.0DomainRGS
HgeneAXIN1chr16:354304chr17:34867294ENST00000262320-51120_29418863.0MotifNote=Tankyrase-binding motif
HgeneAXIN1chr16:354304chr17:34867294ENST00000354866-51020_29418827.0MotifNote=Tankyrase-binding motif
TgeneMYO19chr16:354304chr17:34867294ENST000002688521022759_779298771.0DomainIQ 1
TgeneMYO19chr16:354304chr17:34867294ENST000002688521022783_812298771.0DomainIQ 2
TgeneMYO19chr16:354304chr17:34867294ENST000004317941026759_779298971.0DomainIQ 1
TgeneMYO19chr16:354304chr17:34867294ENST000004317941026783_812298971.0DomainIQ 2
TgeneMYO19chr16:354304chr17:34867294ENST0000058600701135_7580318.0DomainMyosin motor
TgeneMYO19chr16:354304chr17:34867294ENST00000586007011759_7790318.0DomainIQ 1
TgeneMYO19chr16:354304chr17:34867294ENST00000586007011783_8120318.0DomainIQ 2
TgeneMYO19chr16:354304chr17:34867294ENST00000586007011132_1390318.0Nucleotide bindingATP
TgeneMYO19chr16:354304chr17:34867294ENST000002688521022602_624298771.0RegionActin-binding
TgeneMYO19chr16:354304chr17:34867294ENST000002688521022824_970298771.0RegionMyMOMA region
TgeneMYO19chr16:354304chr17:34867294ENST000004317941026602_624298971.0RegionActin-binding
TgeneMYO19chr16:354304chr17:34867294ENST000004317941026824_970298971.0RegionMyMOMA region
TgeneMYO19chr16:354304chr17:34867294ENST00000586007011602_6240318.0RegionActin-binding
TgeneMYO19chr16:354304chr17:34867294ENST00000586007011824_9700318.0RegionMyMOMA region

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAXIN1chr16:354304chr17:34867294ENST00000262320-511780_862418863.0DomainDIX
HgeneAXIN1chr16:354304chr17:34867294ENST00000354866-510780_862418827.0DomainDIX
TgeneMYO19chr16:354304chr17:34867294ENST00000268852102235_758298771.0DomainMyosin motor
TgeneMYO19chr16:354304chr17:34867294ENST00000431794102635_758298971.0DomainMyosin motor
TgeneMYO19chr16:354304chr17:34867294ENST000002688521022132_139298771.0Nucleotide bindingATP
TgeneMYO19chr16:354304chr17:34867294ENST000004317941026132_139298971.0Nucleotide bindingATP


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Fusion Gene Sequence for AXIN1-MYO19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8563_8563_1_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000262320_MYO19_chr17_34867294_ENST00000268852_length(transcript)=3541nt_BP=1626nt
CTCGGGAGGCGATCGTGGCCGCTGCCGCCGCCAGAGCCGGCCGGAGTCGGCCCGGAGCCGCGTCCACGCGGAGCGGGCGGGTGGGAGCTG
GCGGCTGGGCCCCTGCGGCGCCCCCGCGGCCTGCCCCGCGTCCGCCTCCGGGCCGCCGAGCCGCAGCCGCCGAGATGGGGGCCGCCCCGG
GCCGCGCCCCCGCCGGGTCCCGCCCGCCGCGCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGG
TCCCGCCACCACCGCGCGCGGGACAGATTGATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACG
CAGAGTCCCAAAATGAATATCCAAGAGCAGGGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCT
GGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACT
TCGACGGCCACTCCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCT
GAGTCACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGAC
TTCTGGTTTGCCTGCACTGGCTTCAGGAAGCTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGA
AAGTACATTCTTGATAACAATGGCATCGTGTCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTG
ATCGATCCTGCCATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATT
TATTTGGAATATACGAGGACAGGCTCGGAGAGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGA
TACCTGCCGACCTTAAATGAAGATGAGGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGA
CTCCCTCAGAAGCTGCTCCTGGAGACAGCTGCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCC
TGGCGGGAGCCAGTCAACCCCTATTATGTCAATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTG
TCCAGCGATGCAGACACCCTGTCCCTCACGGACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATG
CAGGAGAGCGTGCAGGTCAATGGGCGGGTGCCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAG
AAGTTCGCGGAGGAGCTCATCCACCGCCTGGAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTG
CGCATGGTCCTAGCTGGACTGCTGCACCTTGGCAATATCCAGTTTGCTGCCTCCGAGGATGAAGCCCAGCCCTGCCAGCCGATGGATGAT
GCCAAGTACTCTGTCAGGACGGCAGCCTCGCTGCTGGGGCTCCCAGAGGACGTGCTGCTGGAGATGGTGCAGATTAGAACCATCAGGGCA
GGCAGACAGCAGCAGGTGTTCCGGAAGCCCTGCGCCCGAGCCGAGTGTGACACCCGTAGAGACTGCCTGGCCAAACTGATCTATGCGCGG
TTGTTTGACTGGCTGGTATCAGTGATCAACAGCAGCATCTGTGCAGACACCGACTCGTGGACCACTTTCATAGGCCTGCTGGATGTGTAT
GGATTTGAATCATTTCCTGACAACAGTCTGGAACAGTTGTGCATCAACTACGCCAATGAGAAGCTCCAGCTGGAGGCCTGTGGCCTCGTG
GAGACCATCCATATCAGTGCTGCTGGCTTCCCCATCCGGGTCTCTCACCGAAACTTTGTAGAACGATACAAGTTACTAAGAAGGCTTCAT
CCTTGCACATCCTCTGGCCCCGACAGCCCATATCCTGCCAAAGGGCTCCCTGAATGGTGTCCACACAGCGAGGAAGCCACGCTTGAACCT
CTCATCCAGGACATTCTCCACACTCTGCCGGTCCTAACTCAGGCAGCAGCCATAACTGGTGACTCGGCTGAGGCCATGCCAGCCCCCATG
CACTGTGGCAGGACCAAGGTGTTCATGACTGACTCTATGCTGGAGCTTCTGGAATGTGGGCGTGCCCGGGTGCTGGAGCAGTGTGCCCGC
TGCATCCAGGGTGGCTGGAGGCGACACCGGCACCGAGAGCAGGAGCGGCAGTGGCGGGCCGTCATGCTCATCCAGGCAGCCATTCGTTCC
TGGTTAACTCGGAAACACATCCAGAGGCTGCATGCAGCTGCCACAGTCATCAAGCGTGCATGGCAGAAGTGGAGAATCAGAATGGCCTGC
CTTGCTGCTAAAGAGCTGGATGGTGTGGAAGAAAAACACTTCTCTCAAGCTCCCTGTTCCCTGAGCACCTCGCCGCTGCAGACCAGGCTC
CTGGAGGCAATAATCCGCCTCTGGCCCCTGGGACTGGTCCTGGCCAATACGGCTATGGGTGTAGGCAGCTTTCAGAGGAAATTAGTGGTC
TGGGCTTGCCTCCAGCTCCCCAGGGGCAGCCCCAGTAGCTACACTGTCCAGACAGCACAAGACCAGGCTGGTGTCACGTCCATCCGAGCG
CTGCCTCAGGGATCGATAAAGTTTCACTGCAGAAAGTCTCCACTGCGGTATGCTGACATCTGCCCTGAACCTTCACCCTACAGCATTACA
GGCTTTAATCAGATTCTGCTGGAAAGACACAGGCTGATCCACGTGACCTCTTCTGCCTTCACTGGGCTGGGGTGATCCTTGGTGCCTTTG
TTTCCACAAGGCCTTTTCCTGCCCCCTGCCTTGCCAAAGACATTTAATCAGCACACAGCTGCCAGACTATTCCCACAGTGCTCCAAATGC
ACATGAACAACAGTGACGGCTCCAGCCTTCGACCCAGAGCCCCGTGCCCAGTGCGTCAGTGGGCCTGGGGTTCCAGGCTACATCAAGCAC
TGATGGTGTCAGGGCTGGTAGTTACCAAATCAGGGTTAAGAAACATCAGGGCCACATTTCACTACCTTCACAGATCAAACTCAGCAGCAG
TCATGACTGTCTGTCACTACACTGGGGATCCCAATTCCACATAAGCACTTTTGGAAGAAAACAGCCAAAGTTGGCCTAAAATTGGCGCTG
GAATTTGGGCTGGGAAAAATCTTGTGGTTATTTCCTTTAAAAAGGAACAAAACTTTAGTATTTAATTAGTTGATTTATTTAATGTAATTT

>8563_8563_1_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000262320_MYO19_chr17_34867294_ENST00000268852_length(amino acids)=1007AA_BP=535
MPPPEPAGVGPEPRPRGAGGWELAAGPLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGPARRAAAERMGPDRAAPLREPGPGSRHHRAR
DRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRR
SDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNN
GIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE
DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTL
SLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMVLAGL
LHLGNIQFAASEDEAQPCQPMDDAKYSVRTAASLLGLPEDVLLEMVQIRTIRAGRQQQVFRKPCARAECDTRRDCLAKLIYARLFDWLVS
VINSSICADTDSWTTFIGLLDVYGFESFPDNSLEQLCINYANEKLQLEACGLVETIHISAAGFPIRVSHRNFVERYKLLRRLHPCTSSGP
DSPYPAKGLPEWCPHSEEATLEPLIQDILHTLPVLTQAAAITGDSAEAMPAPMHCGRTKVFMTDSMLELLECGRARVLEQCARCIQGGWR
RHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIRMACLAAKELDGVEEKHFSQAPCSLSTSPLQTRLLEAIIRL
WPLGLVLANTAMGVGSFQRKLVVWACLQLPRGSPSSYTVQTAQDQAGVTSIRALPQGSIKFHCRKSPLRYADICPEPSPYSITGFNQILL

--------------------------------------------------------------
>8563_8563_2_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000262320_MYO19_chr17_34867294_ENST00000431794_length(transcript)=4263nt_BP=1626nt
CTCGGGAGGCGATCGTGGCCGCTGCCGCCGCCAGAGCCGGCCGGAGTCGGCCCGGAGCCGCGTCCACGCGGAGCGGGCGGGTGGGAGCTG
GCGGCTGGGCCCCTGCGGCGCCCCCGCGGCCTGCCCCGCGTCCGCCTCCGGGCCGCCGAGCCGCAGCCGCCGAGATGGGGGCCGCCCCGG
GCCGCGCCCCCGCCGGGTCCCGCCCGCCGCGCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGG
TCCCGCCACCACCGCGCGCGGGACAGATTGATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACG
CAGAGTCCCAAAATGAATATCCAAGAGCAGGGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCT
GGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACT
TCGACGGCCACTCCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCT
GAGTCACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGAC
TTCTGGTTTGCCTGCACTGGCTTCAGGAAGCTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGA
AAGTACATTCTTGATAACAATGGCATCGTGTCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTG
ATCGATCCTGCCATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATT
TATTTGGAATATACGAGGACAGGCTCGGAGAGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGA
TACCTGCCGACCTTAAATGAAGATGAGGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGA
CTCCCTCAGAAGCTGCTCCTGGAGACAGCTGCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCC
TGGCGGGAGCCAGTCAACCCCTATTATGTCAATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTG
TCCAGCGATGCAGACACCCTGTCCCTCACGGACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATG
CAGGAGAGCGTGCAGGTCAATGGGCGGGTGCCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAG
AAGTTCGCGGAGGAGCTCATCCACCGCCTGGAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTG
CGCATGGTCCTAGCTGGACTGCTGCACCTTGGCAATATCCAGTTTGCTGCCTCCGAGGATGAAGCCCAGCCCTGCCAGCCGATGGATGAT
GCCAAGTACTCTGTCAGGACGGCAGCCTCGCTGCTGGGGCTCCCAGAGGACGTGCTGCTGGAGATGGTGCAGATTAGAACCATCAGGGCA
GGCAGACAGCAGCAGGTGTTCCGGAAGCCCTGCGCCCGAGCCGAGTGTGACACCCGTAGAGACTGCCTGGCCAAACTGATCTATGCGCGG
TTGTTTGACTGGCTGGTATCAGTGATCAACAGCAGCATCTGTGCAGACACCGACTCGTGGACCACTTTCATAGGCCTGCTGGATGTGTAT
GGATTTGAATCATTTCCTGACAACAGTCTGGAACAGTTGTGCATCAACTACGCCAATGAGAAGCTGCAGCAGCATTTTGTGGCTCACTAC
CTAAGGGCCCAGCAGGAGGAATACGCAGTTGAGGGCCTGGAGTGGTCATTCATCAACTACCAGGACAACCAGCCCTGTTTGGATCTCATT
GAGGGAAGCCCCATCAGCATCTGCTCCCTCATAAATGAGGAATGCCGCCTCAATCGACCCAGCAGCGCAGCCCAGCTCCAGACACGCATT
GAGACTGCCCTGGCAGGCAGCCCCTGCCTGGGCCACAATAAGCTCAGCCGGGAGCCCAGCTTCATTGTGGTGCATTATGCGGGGCCTGTG
CGGTACCACACAGCAGGCCTGGTGGAGAAGAACAAGGACCCTATCCCACCTGAGCTGACCAGGCTCCTGCAGCAATCCCAGGACCCCCTG
CTCATGGGGCTGTTTCCTACTAACCCCAAAGAGAAGACCCAGGAGGAACCCCCTGGCCAGAGCAGGGCCCCTGTGTTGACCGTGGTGTCC
AAGTTCAAGGCCTCACTGGAGCAGCTTCTGCAGGTCCTACACAGCACCACGCCCCACTACATTCGCTGCATCAAGCCCAACAGCCAGGGC
CAGGCGCAGACCTTTCTCCAAGAGGAGGTCCTGAGCCAGCTGGAGGCCTGTGGCCTCGTGGAGACCATCCATATCAGTGCTGCTGGCTTC
CCCATCCGGGTCTCTCACCGAAACTTTGTAGAACGATACAAGTTACTAAGAAGGCTTCATCCTTGCACATCCTCTGGCCCCGACAGCCCA
TATCCTGCCAAAGGGCTCCCTGAATGGTGTCCACACAGCGAGGAAGCCACGCTTGAACCTCTCATCCAGGACATTCTCCACACTCTGCCG
GTCCTAACTCAGGCAGCAGCCATAACTGGTGACTCGGCTGAGGCCATGCCAGCCCCCATGCACTGTGGCAGGACCAAGGTGTTCATGACT
GACTCTATGCTGGAGCTTCTGGAATGTGGGCGTGCCCGGGTGCTGGAGCAGTGTGCCCGCTGCATCCAGGGTGGCTGGAGGCGACACCGG
CACCGAGAGCAGGAGCGGCAGTGGCGGGCCGTCATGCTCATCCAGGCAGCCATTCGTTCCTGGTTAACTCGGAAACACATCCAGAGGCTG
CATGCAGCTGCCACAGTCATCAAGCGTGCATGGCAGAAGTGGAGAATCAGAATGGCCTGCCTTGCTGCTAAAGAGCTGGATGGTGTGGAA
GAAAAACACTTCTCTCAAGCTCCCTGTTCCCTGAGCACCTCGCCGCTGCAGACCAGGCTCCTGGAGGCAATAATCCGCCTCTGGCCCCTG
GGACTGGTCCTGGCCAATACGGCTATGGGTGTAGGCAGCTTTCAGAGGAAATTAGTGGTCTGGGCTTGCCTCCAGCTCCCCAGGGGCAGC
CCCAGTAGCTACACTGTCCAGACAGCACAAGACCAGGCTGGTGTCACGTCCATCCGAGCGCTGCCTCAGGGATCGATAAAGTTTCACTGC
AGAAAGTCTCCACTGCGGTATGCTGACATCTGCCCTGAACCTTCACCCTACAGCATTACAGGCTTTAATCAGATTCTGCTGGAAAGACAC
AGGCTGATCCACGTGACCTCTTCTGCCTTCACTGGGCTGGGGTGATCCTTGGTGCCTTTGTTTCCACAAGGCCTTTTCCTGCCCCCTGCC
TTGCCAAAGACATTTAATCAGCACACAGCTGCCAGACTATTCCCACAGTGCTCCAAATGCACATGAACAACAGTGACGGCTCCAGCCTTC
GACCCAGAGCCCCGTGCCCAGTGCGTCAGTGGGCCTGGGGTTCCAGGCTACATCAAGCACTGATGGTGTCAGGGCTGGTAGTTACCAAAT
CAGGGTTAAGAAACATCAGGGCCACATTTCACTACCTTCACAGATCAAACTCAGCAGCAGTCATGACTGTCTGTCACTACACTGGGGATC
CCAATTCCACATAAGCACTTTTGGAAGAAAACAGCCAAAGTTGGCCTAAAATTGGCGCTGGAATTTGGGCTGGGAAAAATCTTGTGGTTA
TTTCCTTTAAAAAGGAACAAAACTTTAGTATTTAATTAGTTGATTTATTTAATGTAATTTCAAACAATTAAATTATGAATAATGCAATGT
ACAGTAGAATCACGTTTTGATTTTATTAACACTGACCAAGTTTAACTCCATATGAAGTGTAAGCTTGATATCGTTTATGATGTCTATCAA

>8563_8563_2_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000262320_MYO19_chr17_34867294_ENST00000431794_length(amino acids)=1207AA_BP=535
MPPPEPAGVGPEPRPRGAGGWELAAGPLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGPARRAAAERMGPDRAAPLREPGPGSRHHRAR
DRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRR
SDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNN
GIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE
DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTL
SLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMVLAGL
LHLGNIQFAASEDEAQPCQPMDDAKYSVRTAASLLGLPEDVLLEMVQIRTIRAGRQQQVFRKPCARAECDTRRDCLAKLIYARLFDWLVS
VINSSICADTDSWTTFIGLLDVYGFESFPDNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAVEGLEWSFINYQDNQPCLDLIEGSPISI
CSLINEECRLNRPSSAAQLQTRIETALAGSPCLGHNKLSREPSFIVVHYAGPVRYHTAGLVEKNKDPIPPELTRLLQQSQDPLLMGLFPT
NPKEKTQEEPPGQSRAPVLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQGQAQTFLQEEVLSQLEACGLVETIHISAAGFPIRVSHR
NFVERYKLLRRLHPCTSSGPDSPYPAKGLPEWCPHSEEATLEPLIQDILHTLPVLTQAAAITGDSAEAMPAPMHCGRTKVFMTDSMLELL
ECGRARVLEQCARCIQGGWRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIRMACLAAKELDGVEEKHFSQA
PCSLSTSPLQTRLLEAIIRLWPLGLVLANTAMGVGSFQRKLVVWACLQLPRGSPSSYTVQTAQDQAGVTSIRALPQGSIKFHCRKSPLRY

--------------------------------------------------------------
>8563_8563_3_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000354866_MYO19_chr17_34867294_ENST00000268852_length(transcript)=3331nt_BP=1416nt
GCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGGTCCCGCCACCACCGCGCGCGGGACAGATTG
ATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACGCAGAGTCCCAAAATGAATATCCAAGAGCAG
GGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGAC
CCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACTTCGACGGCCACTCCGAGGCGCTCGGATCTG
GACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCTGAGTCACTGCATTCCCTGCTGGATGACCAA
GATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGACTTCTGGTTTGCCTGCACTGGCTTCAGGAAG
CTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGAAAGTACATTCTTGATAACAATGGCATCGTG
TCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTGATCGATCCTGCCATGTTTGACCAGGCCCAG
ACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATTTATTTGGAATATACGAGGACAGGCTCGGAG
AGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGATACCTGCCGACCTTAAATGAAGATGAGGAA
TGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCTGGAGACAGCT
GCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCCTGGCGGGAGCCAGTCAACCCCTATTATGTC
AATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACG
GACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATGCAGGAGAGCGTGCAGGTCAATGGGCGGGTG
CCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAGAAGTTCGCGGAGGAGCTCATCCACCGCCTG
GAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTGCGCATGGTCCTAGCTGGACTGCTGCACCTT
GGCAATATCCAGTTTGCTGCCTCCGAGGATGAAGCCCAGCCCTGCCAGCCGATGGATGATGCCAAGTACTCTGTCAGGACGGCAGCCTCG
CTGCTGGGGCTCCCAGAGGACGTGCTGCTGGAGATGGTGCAGATTAGAACCATCAGGGCAGGCAGACAGCAGCAGGTGTTCCGGAAGCCC
TGCGCCCGAGCCGAGTGTGACACCCGTAGAGACTGCCTGGCCAAACTGATCTATGCGCGGTTGTTTGACTGGCTGGTATCAGTGATCAAC
AGCAGCATCTGTGCAGACACCGACTCGTGGACCACTTTCATAGGCCTGCTGGATGTGTATGGATTTGAATCATTTCCTGACAACAGTCTG
GAACAGTTGTGCATCAACTACGCCAATGAGAAGCTCCAGCTGGAGGCCTGTGGCCTCGTGGAGACCATCCATATCAGTGCTGCTGGCTTC
CCCATCCGGGTCTCTCACCGAAACTTTGTAGAACGATACAAGTTACTAAGAAGGCTTCATCCTTGCACATCCTCTGGCCCCGACAGCCCA
TATCCTGCCAAAGGGCTCCCTGAATGGTGTCCACACAGCGAGGAAGCCACGCTTGAACCTCTCATCCAGGACATTCTCCACACTCTGCCG
GTCCTAACTCAGGCAGCAGCCATAACTGGTGACTCGGCTGAGGCCATGCCAGCCCCCATGCACTGTGGCAGGACCAAGGTGTTCATGACT
GACTCTATGCTGGAGCTTCTGGAATGTGGGCGTGCCCGGGTGCTGGAGCAGTGTGCCCGCTGCATCCAGGGTGGCTGGAGGCGACACCGG
CACCGAGAGCAGGAGCGGCAGTGGCGGGCCGTCATGCTCATCCAGGCAGCCATTCGTTCCTGGTTAACTCGGAAACACATCCAGAGGCTG
CATGCAGCTGCCACAGTCATCAAGCGTGCATGGCAGAAGTGGAGAATCAGAATGGCCTGCCTTGCTGCTAAAGAGCTGGATGGTGTGGAA
GAAAAACACTTCTCTCAAGCTCCCTGTTCCCTGAGCACCTCGCCGCTGCAGACCAGGCTCCTGGAGGCAATAATCCGCCTCTGGCCCCTG
GGACTGGTCCTGGCCAATACGGCTATGGGTGTAGGCAGCTTTCAGAGGAAATTAGTGGTCTGGGCTTGCCTCCAGCTCCCCAGGGGCAGC
CCCAGTAGCTACACTGTCCAGACAGCACAAGACCAGGCTGGTGTCACGTCCATCCGAGCGCTGCCTCAGGGATCGATAAAGTTTCACTGC
AGAAAGTCTCCACTGCGGTATGCTGACATCTGCCCTGAACCTTCACCCTACAGCATTACAGGCTTTAATCAGATTCTGCTGGAAAGACAC
AGGCTGATCCACGTGACCTCTTCTGCCTTCACTGGGCTGGGGTGATCCTTGGTGCCTTTGTTTCCACAAGGCCTTTTCCTGCCCCCTGCC
TTGCCAAAGACATTTAATCAGCACACAGCTGCCAGACTATTCCCACAGTGCTCCAAATGCACATGAACAACAGTGACGGCTCCAGCCTTC
GACCCAGAGCCCCGTGCCCAGTGCGTCAGTGGGCCTGGGGTTCCAGGCTACATCAAGCACTGATGGTGTCAGGGCTGGTAGTTACCAAAT
CAGGGTTAAGAAACATCAGGGCCACATTTCACTACCTTCACAGATCAAACTCAGCAGCAGTCATGACTGTCTGTCACTACACTGGGGATC
CCAATTCCACATAAGCACTTTTGGAAGAAAACAGCCAAAGTTGGCCTAAAATTGGCGCTGGAATTTGGGCTGGGAAAAATCTTGTGGTTA
TTTCCTTTAAAAAGGAACAAAACTTTAGTATTTAATTAGTTGATTTATTTAATGTAATTTCAAACAATTAAATTATGAATAATGCAATGT

>8563_8563_3_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000354866_MYO19_chr17_34867294_ENST00000268852_length(amino acids)=939AA_BP=467
MGPDRAAPLREPGPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPAS
YSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCD
SNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC
SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYA
LAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQR
TREAEEKLEERLKRVRMVLAGLLHLGNIQFAASEDEAQPCQPMDDAKYSVRTAASLLGLPEDVLLEMVQIRTIRAGRQQQVFRKPCARAE
CDTRRDCLAKLIYARLFDWLVSVINSSICADTDSWTTFIGLLDVYGFESFPDNSLEQLCINYANEKLQLEACGLVETIHISAAGFPIRVS
HRNFVERYKLLRRLHPCTSSGPDSPYPAKGLPEWCPHSEEATLEPLIQDILHTLPVLTQAAAITGDSAEAMPAPMHCGRTKVFMTDSMLE
LLECGRARVLEQCARCIQGGWRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIRMACLAAKELDGVEEKHFS
QAPCSLSTSPLQTRLLEAIIRLWPLGLVLANTAMGVGSFQRKLVVWACLQLPRGSPSSYTVQTAQDQAGVTSIRALPQGSIKFHCRKSPL

--------------------------------------------------------------
>8563_8563_4_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000354866_MYO19_chr17_34867294_ENST00000431794_length(transcript)=4053nt_BP=1416nt
GCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGGTCCCGCCACCACCGCGCGCGGGACAGATTG
ATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACGCAGAGTCCCAAAATGAATATCCAAGAGCAG
GGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGAC
CCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACTTCGACGGCCACTCCGAGGCGCTCGGATCTG
GACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCTGAGTCACTGCATTCCCTGCTGGATGACCAA
GATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGACTTCTGGTTTGCCTGCACTGGCTTCAGGAAG
CTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGAAAGTACATTCTTGATAACAATGGCATCGTG
TCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTGATCGATCCTGCCATGTTTGACCAGGCCCAG
ACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATTTATTTGGAATATACGAGGACAGGCTCGGAG
AGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGATACCTGCCGACCTTAAATGAAGATGAGGAA
TGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCTGGAGACAGCT
GCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCCTGGCGGGAGCCAGTCAACCCCTATTATGTC
AATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACG
GACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATGCAGGAGAGCGTGCAGGTCAATGGGCGGGTG
CCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAGAAGTTCGCGGAGGAGCTCATCCACCGCCTG
GAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTGCGCATGGTCCTAGCTGGACTGCTGCACCTT
GGCAATATCCAGTTTGCTGCCTCCGAGGATGAAGCCCAGCCCTGCCAGCCGATGGATGATGCCAAGTACTCTGTCAGGACGGCAGCCTCG
CTGCTGGGGCTCCCAGAGGACGTGCTGCTGGAGATGGTGCAGATTAGAACCATCAGGGCAGGCAGACAGCAGCAGGTGTTCCGGAAGCCC
TGCGCCCGAGCCGAGTGTGACACCCGTAGAGACTGCCTGGCCAAACTGATCTATGCGCGGTTGTTTGACTGGCTGGTATCAGTGATCAAC
AGCAGCATCTGTGCAGACACCGACTCGTGGACCACTTTCATAGGCCTGCTGGATGTGTATGGATTTGAATCATTTCCTGACAACAGTCTG
GAACAGTTGTGCATCAACTACGCCAATGAGAAGCTGCAGCAGCATTTTGTGGCTCACTACCTAAGGGCCCAGCAGGAGGAATACGCAGTT
GAGGGCCTGGAGTGGTCATTCATCAACTACCAGGACAACCAGCCCTGTTTGGATCTCATTGAGGGAAGCCCCATCAGCATCTGCTCCCTC
ATAAATGAGGAATGCCGCCTCAATCGACCCAGCAGCGCAGCCCAGCTCCAGACACGCATTGAGACTGCCCTGGCAGGCAGCCCCTGCCTG
GGCCACAATAAGCTCAGCCGGGAGCCCAGCTTCATTGTGGTGCATTATGCGGGGCCTGTGCGGTACCACACAGCAGGCCTGGTGGAGAAG
AACAAGGACCCTATCCCACCTGAGCTGACCAGGCTCCTGCAGCAATCCCAGGACCCCCTGCTCATGGGGCTGTTTCCTACTAACCCCAAA
GAGAAGACCCAGGAGGAACCCCCTGGCCAGAGCAGGGCCCCTGTGTTGACCGTGGTGTCCAAGTTCAAGGCCTCACTGGAGCAGCTTCTG
CAGGTCCTACACAGCACCACGCCCCACTACATTCGCTGCATCAAGCCCAACAGCCAGGGCCAGGCGCAGACCTTTCTCCAAGAGGAGGTC
CTGAGCCAGCTGGAGGCCTGTGGCCTCGTGGAGACCATCCATATCAGTGCTGCTGGCTTCCCCATCCGGGTCTCTCACCGAAACTTTGTA
GAACGATACAAGTTACTAAGAAGGCTTCATCCTTGCACATCCTCTGGCCCCGACAGCCCATATCCTGCCAAAGGGCTCCCTGAATGGTGT
CCACACAGCGAGGAAGCCACGCTTGAACCTCTCATCCAGGACATTCTCCACACTCTGCCGGTCCTAACTCAGGCAGCAGCCATAACTGGT
GACTCGGCTGAGGCCATGCCAGCCCCCATGCACTGTGGCAGGACCAAGGTGTTCATGACTGACTCTATGCTGGAGCTTCTGGAATGTGGG
CGTGCCCGGGTGCTGGAGCAGTGTGCCCGCTGCATCCAGGGTGGCTGGAGGCGACACCGGCACCGAGAGCAGGAGCGGCAGTGGCGGGCC
GTCATGCTCATCCAGGCAGCCATTCGTTCCTGGTTAACTCGGAAACACATCCAGAGGCTGCATGCAGCTGCCACAGTCATCAAGCGTGCA
TGGCAGAAGTGGAGAATCAGAATGGCCTGCCTTGCTGCTAAAGAGCTGGATGGTGTGGAAGAAAAACACTTCTCTCAAGCTCCCTGTTCC
CTGAGCACCTCGCCGCTGCAGACCAGGCTCCTGGAGGCAATAATCCGCCTCTGGCCCCTGGGACTGGTCCTGGCCAATACGGCTATGGGT
GTAGGCAGCTTTCAGAGGAAATTAGTGGTCTGGGCTTGCCTCCAGCTCCCCAGGGGCAGCCCCAGTAGCTACACTGTCCAGACAGCACAA
GACCAGGCTGGTGTCACGTCCATCCGAGCGCTGCCTCAGGGATCGATAAAGTTTCACTGCAGAAAGTCTCCACTGCGGTATGCTGACATC
TGCCCTGAACCTTCACCCTACAGCATTACAGGCTTTAATCAGATTCTGCTGGAAAGACACAGGCTGATCCACGTGACCTCTTCTGCCTTC
ACTGGGCTGGGGTGATCCTTGGTGCCTTTGTTTCCACAAGGCCTTTTCCTGCCCCCTGCCTTGCCAAAGACATTTAATCAGCACACAGCT
GCCAGACTATTCCCACAGTGCTCCAAATGCACATGAACAACAGTGACGGCTCCAGCCTTCGACCCAGAGCCCCGTGCCCAGTGCGTCAGT
GGGCCTGGGGTTCCAGGCTACATCAAGCACTGATGGTGTCAGGGCTGGTAGTTACCAAATCAGGGTTAAGAAACATCAGGGCCACATTTC
ACTACCTTCACAGATCAAACTCAGCAGCAGTCATGACTGTCTGTCACTACACTGGGGATCCCAATTCCACATAAGCACTTTTGGAAGAAA
ACAGCCAAAGTTGGCCTAAAATTGGCGCTGGAATTTGGGCTGGGAAAAATCTTGTGGTTATTTCCTTTAAAAAGGAACAAAACTTTAGTA
TTTAATTAGTTGATTTATTTAATGTAATTTCAAACAATTAAATTATGAATAATGCAATGTACAGTAGAATCACGTTTTGATTTTATTAAC
ACTGACCAAGTTTAACTCCATATGAAGTGTAAGCTTGATATCGTTTATGATGTCTATCAACTGTACCAAAAGTAAAACATTTAAAAACAA

>8563_8563_4_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000354866_MYO19_chr17_34867294_ENST00000431794_length(amino acids)=1139AA_BP=467
MGPDRAAPLREPGPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPAS
YSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCD
SNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC
SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYA
LAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQR
TREAEEKLEERLKRVRMVLAGLLHLGNIQFAASEDEAQPCQPMDDAKYSVRTAASLLGLPEDVLLEMVQIRTIRAGRQQQVFRKPCARAE
CDTRRDCLAKLIYARLFDWLVSVINSSICADTDSWTTFIGLLDVYGFESFPDNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAVEGLEW
SFINYQDNQPCLDLIEGSPISICSLINEECRLNRPSSAAQLQTRIETALAGSPCLGHNKLSREPSFIVVHYAGPVRYHTAGLVEKNKDPI
PPELTRLLQQSQDPLLMGLFPTNPKEKTQEEPPGQSRAPVLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQGQAQTFLQEEVLSQLE
ACGLVETIHISAAGFPIRVSHRNFVERYKLLRRLHPCTSSGPDSPYPAKGLPEWCPHSEEATLEPLIQDILHTLPVLTQAAAITGDSAEA
MPAPMHCGRTKVFMTDSMLELLECGRARVLEQCARCIQGGWRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWR
IRMACLAAKELDGVEEKHFSQAPCSLSTSPLQTRLLEAIIRLWPLGLVLANTAMGVGSFQRKLVVWACLQLPRGSPSSYTVQTAQDQAGV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AXIN1-MYO19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneAXIN1chr16:354304chr17:34867294ENST00000262320-511209_338418.0863.0TP53
HgeneAXIN1chr16:354304chr17:34867294ENST00000354866-510209_338418.0827.0TP53


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAXIN1chr16:354304chr17:34867294ENST00000262320-511434_502418.0863.0CTNNB1
HgeneAXIN1chr16:354304chr17:34867294ENST00000354866-510434_502418.0827.0CTNNB1
HgeneAXIN1chr16:354304chr17:34867294ENST00000262320-511348_433418.0863.0GSK3B
HgeneAXIN1chr16:354304chr17:34867294ENST00000354866-510348_433418.0827.0GSK3B
HgeneAXIN1chr16:354304chr17:34867294ENST00000262320-511677_752418.0863.0HIPK2
HgeneAXIN1chr16:354304chr17:34867294ENST00000354866-510677_752418.0827.0HIPK2
HgeneAXIN1chr16:354304chr17:34867294ENST00000262320-511575_789418.0863.0PPP2CA
HgeneAXIN1chr16:354304chr17:34867294ENST00000354866-510575_789418.0827.0PPP2CA
HgeneAXIN1chr16:354304chr17:34867294ENST00000262320-511507_757418.0863.0RNF111
HgeneAXIN1chr16:354304chr17:34867294ENST00000354866-510507_757418.0827.0RNF111


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AXIN1-MYO19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AXIN1-MYO19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAXIN1C2239176Liver carcinoma2CGI;CTD_human;UNIPROT
HgeneAXIN1C0279607Adult Hepatocellular Carcinoma1ORPHANET