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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:BAP1-PLXNB1 (FusionGDB2 ID:HG8314TG5364) |
Fusion Gene Summary for BAP1-PLXNB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BAP1-PLXNB1 | Fusion gene ID: hg8314tg5364 | Hgene | Tgene | Gene symbol | BAP1 | PLXNB1 | Gene ID | 8314 | 5364 |
| Gene name | BRCA1 associated protein 1 | plexin B1 | |
| Synonyms | HUCEP-13|UCHL2|hucep-6 | PLEXIN-B1|PLXN5|SEP | |
| Cytomap | ('BAP1')('PLXNB1') 3p21.1 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase BAP1BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)cerebral protein 6cerebral protein-13 | plexin-B1plexin 5semaphorin receptor SEP | |
| Modification date | 20200315 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000296288, ENST00000460680, | ||
| Fusion gene scores | * DoF score | 12 X 13 X 7=1092 | 9 X 8 X 5=360 |
| # samples | 13 | 8 | |
| ** MAII score | log2(13/1092*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/360*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BAP1 [Title/Abstract] AND PLXNB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | BAP1(52437154)-PLXNB1(48455480), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | BAP1-PLXNB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BAP1-PLXNB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BAP1-PLXNB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BAP1-PLXNB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BAP1 | GO:0016579 | protein deubiquitination | 18757409|19815555 |
| Hgene | BAP1 | GO:0035520 | monoubiquitinated protein deubiquitination | 24703950 |
| Hgene | BAP1 | GO:0035522 | monoubiquitinated histone H2A deubiquitination | 20436459|25451922 |
| Hgene | BAP1 | GO:0045892 | negative regulation of transcription, DNA-templated | 25451922 |
| Tgene | PLXNB1 | GO:0007162 | negative regulation of cell adhesion | 15218527 |
| Tgene | PLXNB1 | GO:0008360 | regulation of cell shape | 19843518 |
| Tgene | PLXNB1 | GO:0051493 | regulation of cytoskeleton organization | 19843518 |
| Tgene | PLXNB1 | GO:0071526 | semaphorin-plexin signaling pathway | 15218527|19843518 |
| Fusion gene breakpoints across BAP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PLXNB1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | MESO | TCGA-UD-AABY-01A | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - |
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Fusion Gene ORF analysis for BAP1-PLXNB1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000296288 | ENST00000465117 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - |
| 5CDS-5UTR | ENST00000460680 | ENST00000465117 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - |
| In-frame | ENST00000296288 | ENST00000296440 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - |
| In-frame | ENST00000296288 | ENST00000358459 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - |
| In-frame | ENST00000296288 | ENST00000358536 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - |
| In-frame | ENST00000296288 | ENST00000448774 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - |
| In-frame | ENST00000296288 | ENST00000456774 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - |
| In-frame | ENST00000460680 | ENST00000296440 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - |
| In-frame | ENST00000460680 | ENST00000358459 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - |
| In-frame | ENST00000460680 | ENST00000358536 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - |
| In-frame | ENST00000460680 | ENST00000448774 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - |
| In-frame | ENST00000460680 | ENST00000456774 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000460680 | BAP1 | chr3 | 52437154 | - | ENST00000296440 | PLXNB1 | chr3 | 48455480 | - | 5193 | 2362 | 472 | 4560 | 1362 |
| ENST00000460680 | BAP1 | chr3 | 52437154 | - | ENST00000358459 | PLXNB1 | chr3 | 48455480 | - | 5192 | 2362 | 472 | 4560 | 1362 |
| ENST00000460680 | BAP1 | chr3 | 52437154 | - | ENST00000358536 | PLXNB1 | chr3 | 48455480 | - | 5191 | 2362 | 472 | 4560 | 1362 |
| ENST00000460680 | BAP1 | chr3 | 52437154 | - | ENST00000448774 | PLXNB1 | chr3 | 48455480 | - | 4602 | 2362 | 472 | 4560 | 1362 |
| ENST00000460680 | BAP1 | chr3 | 52437154 | - | ENST00000456774 | PLXNB1 | chr3 | 48455480 | - | 4561 | 2362 | 472 | 4560 | 1363 |
| ENST00000296288 | BAP1 | chr3 | 52437154 | - | ENST00000296440 | PLXNB1 | chr3 | 48455480 | - | 4703 | 1872 | 36 | 4070 | 1344 |
| ENST00000296288 | BAP1 | chr3 | 52437154 | - | ENST00000358459 | PLXNB1 | chr3 | 48455480 | - | 4702 | 1872 | 36 | 4070 | 1344 |
| ENST00000296288 | BAP1 | chr3 | 52437154 | - | ENST00000358536 | PLXNB1 | chr3 | 48455480 | - | 4701 | 1872 | 36 | 4070 | 1344 |
| ENST00000296288 | BAP1 | chr3 | 52437154 | - | ENST00000448774 | PLXNB1 | chr3 | 48455480 | - | 4112 | 1872 | 36 | 4070 | 1344 |
| ENST00000296288 | BAP1 | chr3 | 52437154 | - | ENST00000456774 | PLXNB1 | chr3 | 48455480 | - | 4071 | 1872 | 36 | 4070 | 1344 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000460680 | ENST00000296440 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - | 0.005210117 | 0.99478984 |
| ENST00000460680 | ENST00000358459 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - | 0.005180046 | 0.99481994 |
| ENST00000460680 | ENST00000358536 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - | 0.005144639 | 0.9948553 |
| ENST00000460680 | ENST00000448774 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - | 0.005416537 | 0.9945834 |
| ENST00000460680 | ENST00000456774 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - | 0.005325202 | 0.9946748 |
| ENST00000296288 | ENST00000296440 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - | 0.004014745 | 0.99598527 |
| ENST00000296288 | ENST00000358459 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - | 0.003987219 | 0.9960128 |
| ENST00000296288 | ENST00000358536 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - | 0.003954391 | 0.99604553 |
| ENST00000296288 | ENST00000448774 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - | 0.004180635 | 0.99581933 |
| ENST00000296288 | ENST00000456774 | BAP1 | chr3 | 52437154 | - | PLXNB1 | chr3 | 48455480 | - | 0.004114943 | 0.9958851 |
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Fusion Genomic Features for BAP1-PLXNB1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for BAP1-PLXNB1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52437154/chr3:48455480) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000296440 | 20 | 38 | 1507_1539 | 1403 | 2136.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358459 | 21 | 39 | 1507_1539 | 1220 | 1953.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358536 | 20 | 38 | 1507_1539 | 1403 | 2136.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000456774 | 19 | 37 | 1507_1539 | 1220 | 1953.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358459 | 21 | 39 | 1252_1375 | 1220 | 1953.0 | Domain | Note=IPT/TIG 3 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000456774 | 19 | 37 | 1252_1375 | 1220 | 1953.0 | Domain | Note=IPT/TIG 3 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000296440 | 20 | 38 | 1512_2135 | 1403 | 2136.0 | Topological domain | Cytoplasmic | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358459 | 21 | 39 | 1512_2135 | 1220 | 1953.0 | Topological domain | Cytoplasmic | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358536 | 20 | 38 | 1512_2135 | 1403 | 2136.0 | Topological domain | Cytoplasmic | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000456774 | 19 | 37 | 1512_2135 | 1220 | 1953.0 | Topological domain | Cytoplasmic | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000296440 | 20 | 38 | 1491_1511 | 1403 | 2136.0 | Transmembrane | Helical | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358459 | 21 | 39 | 1491_1511 | 1220 | 1953.0 | Transmembrane | Helical | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358536 | 20 | 38 | 1491_1511 | 1403 | 2136.0 | Transmembrane | Helical | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000456774 | 19 | 37 | 1491_1511 | 1220 | 1953.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BAP1 | chr3:52437154 | chr3:48455480 | ENST00000460680 | - | 14 | 17 | 630_661 | 630 | 730.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000296440 | 20 | 38 | 678_829 | 1403 | 2136.0 | Compositional bias | Note=Pro-rich | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358459 | 21 | 39 | 678_829 | 1220 | 1953.0 | Compositional bias | Note=Pro-rich | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358536 | 20 | 38 | 678_829 | 1403 | 2136.0 | Compositional bias | Note=Pro-rich | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000456774 | 19 | 37 | 678_829 | 1220 | 1953.0 | Compositional bias | Note=Pro-rich | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000296440 | 20 | 38 | 1070_1160 | 1403 | 2136.0 | Domain | Note=IPT/TIG 1 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000296440 | 20 | 38 | 1162_1249 | 1403 | 2136.0 | Domain | Note=IPT/TIG 2 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000296440 | 20 | 38 | 1252_1375 | 1403 | 2136.0 | Domain | Note=IPT/TIG 3 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000296440 | 20 | 38 | 20_479 | 1403 | 2136.0 | Domain | Sema | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358459 | 21 | 39 | 1070_1160 | 1220 | 1953.0 | Domain | Note=IPT/TIG 1 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358459 | 21 | 39 | 1162_1249 | 1220 | 1953.0 | Domain | Note=IPT/TIG 2 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358459 | 21 | 39 | 20_479 | 1220 | 1953.0 | Domain | Sema | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358536 | 20 | 38 | 1070_1160 | 1403 | 2136.0 | Domain | Note=IPT/TIG 1 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358536 | 20 | 38 | 1162_1249 | 1403 | 2136.0 | Domain | Note=IPT/TIG 2 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358536 | 20 | 38 | 1252_1375 | 1403 | 2136.0 | Domain | Note=IPT/TIG 3 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358536 | 20 | 38 | 20_479 | 1403 | 2136.0 | Domain | Sema | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000456774 | 19 | 37 | 1070_1160 | 1220 | 1953.0 | Domain | Note=IPT/TIG 1 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000456774 | 19 | 37 | 1162_1249 | 1220 | 1953.0 | Domain | Note=IPT/TIG 2 | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000456774 | 19 | 37 | 20_479 | 1220 | 1953.0 | Domain | Sema | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000296440 | 20 | 38 | 20_1490 | 1403 | 2136.0 | Topological domain | Extracellular | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358459 | 21 | 39 | 20_1490 | 1220 | 1953.0 | Topological domain | Extracellular | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000358536 | 20 | 38 | 20_1490 | 1403 | 2136.0 | Topological domain | Extracellular | |
| Tgene | PLXNB1 | chr3:52437154 | chr3:48455480 | ENST00000456774 | 19 | 37 | 20_1490 | 1220 | 1953.0 | Topological domain | Extracellular |
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Fusion Gene Sequence for BAP1-PLXNB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >8973_8973_1_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000296288_PLXNB1_chr3_48455480_ENST00000296440_length(transcript)=4703nt_BP=1872nt CCTGGACATGGCGCTGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTC GTGGAAGATTTCGGTGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTC CTGTTCAAATGGATCGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAAT AACATGTTCTTTGCCCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTG GGACCCACCCTGAGTCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCC AAGGCCCATAATAGCCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTC CACTTTGTCAGCTATGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAG GACGAGGAGTGGACAGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGATCAAGTATGAGGCCAGGCTGCAT GTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGCTGATAAGAGTAACACAGCCAGAGCTGATTCAGACCCACAAGTCT CAAGAGTCACAGCTGCCTGAGGAGTCCAAGTCAGCCAGCAACAAGTCCCCGCTGGTGCTGGAAGCAAACAGGGCCCCTGCAGCCTCTGAG GGCAACCACACAGATGGTGCAGAGGAGGCGGCTGGTTCATGCGCACAAGCCCCATCCCACAGCCCTCCCAACAAACCCAAGCTAGTGGTG AAGCCTCCAGGCAGCAGCCTCAATGGGGTTCACCCCAACCCCACTCCCATTGTCCAGCGGCTGCCGGCCTTTCTAGACAATCACAATTAT GCCAAGTCCCCCATGCAGGAGGAAGAAGACCTGGCGGCAGGTGTGGGCCGCAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTACTCAGAT GATGAGGATGACTATGAGGATGACGAGGAGGATGACGTGCAGAACACCAACTCTGCCCTTAGGTATAAGGGGAAGGGAACAGGGAAGCCA GGGGCATTGAGCGGTTCTGCTGATGGGCAACTGTCAGTGCTGCAGCCCAACACCATCAACGTCTTGGCTGAGAAGCTCAAAGAGTCCCAG AAGGACCTCTCAATTCCTCTGTCCATCAAGACTAGCAGCGGGGCTGGGAGTCCGGCTGTGGCAGTGCCCACACACTCGCAGCCCTCACCC ACCCCCAGCAATGAGAGTACAGACACGGCCTCTGAGATCGGCAGTGCTTTCAACTCGCCACTGCGCTCGCCTATCCGCTCAGCCAACCCG ACGCGGCCCTCCAGCCCTGTCACCTCCCACATCTCCAAGGTGCTTTTTGGAGAGGATGACAGCCTGCTGCGTGTTGACTGCATACGCTAC AACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGCCTGCTGCACCTGGCTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACA GAGGGTGGGAAGGGTTCCTCGCCCTCCATCAGACCAATCCAAGGCAGCCAGGGGTCCAGCAGCCCAGTGGAGAAGGAGGTCGTGGAAGCC ACGGACAGCAGAGAGAAGACGGGGATGGTGAGGCCTGGCGAGCCCTTGAGTGGGGAGAAATACTCACCCAAGGGGGAGAACCTGGACCTT GCAATGTCCAAGGAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGTGGTGAAGACGCTGACGCGGCACCACCTGTACTGCGAGCCC CCCGTGGAGCAGCCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGACTCTTTGCCTGAGTTCACGGTGCAGATGGGGAACTTGCGC TTCTCCCTGGGTCACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCCTGTGGCAGCCCAGGTGGGCTTGGGGGTGGGCACCTCTCTT CTGGCTCTGGGTGTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAAGCAGGCCCTGAGGGACTATAAGAAGGTTCAGATCCAGCTG GAGAATCTGGAGAGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGACCTCATGACTGAGATGACCGATCTCACCAGTGACCTCCTG GGCAGCGGCATCCCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTTCTTCCCTGGGCACCGCGAGTCGCCCTTGCACCGGGACCTG GGTGTGCCTGAGAGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCTCTCTAACCTGCTCAACAGCAAGCTCTTCCTCACCAAGTTC ATCCACACGCTGGAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTACGTGGCATCTCTGCTCACCGTGGCACTGCATGGGAAGCTT GAGTATTTCACTGACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCAGTATGTGGCCAAGAACCCCAAGCTGATGCTGCGCAGGACA GAGACTGTGGTGGAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTATACCTTCGTGAGGGACTCCGTAGGGGAGCCTCTGTACATG CTCTTTCGAGGGATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGTGACAGGCAAGGCCAAATACACCTTGAACGACAACCGCCTG CTCAGAGAGGATGTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGCTGTGGGGCCTGGGGCAGGAGAGGCCCAGGGCGTGCCCGTG AAGGTCCTAGACTGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGACCAGCTTTATAAAGGAGTGCCTCTCACCCAGCGGCCAGAC CCTCGCACCCTTGATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCATTCTTTCTGACGAGGATGTCACTTCTGAGGTCCAGGGTCTG TGGAGGCGCCTGAACACACTGCAGCATTACAAGGTCCCAGATGGAGCAACTGTGGCCCTCGTCCCCTGCCTCACCAAGCATGTGCTCCGG GAAAACCAGGATTATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGTAGATGAGGGGGGCATCCGGCCCTGGCACCTGGTGAAGCCA AGTGATGAGCCGGAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGGGGAGCGTGAGCGCGCCAAGGCCATCCCTGAGATCTACCTG ACCCGCCTGCTGTCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCTGTTCCAGGTGATTCTCAGCACCAGCCGCCCCGTGCCGCTC GCTGTGAAGTACTTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGGCATCTCCGACCAGGACACCATCCACATCTGGAAGACCAAC AGCTTGCCTCTGAGGTTCTGGATCAATATAATAAAAAACCCGCAGTTTGTGTTCGACGTGCAAACATCTGATAACATGGATGCGGTGCTC CTTGTCATTGCACAGACCTTCATGGACGCCTGCACCCTGGCCGACCACAAGCTGGGCCGGGACTCCCCGATCAACAAACTTCTGTATGCA CGGGACATTCCCCGGTACAAGCGGATGGTGGAAAGGTACTATGCAGACATCAGACAGACTGTCCCAGCCAGCGACCAAGAGATGAACTCT GTCCTGGCTGAACTGTCCTGGAACTACTCCGGAGACCTCGGGGCGCGAGTGGCCCTGCATGAACTCTACAAGTACATCAACAAGTACTAT GACCAGATCATCACTGCCCTGGAGGAGGATGGCACGGCCCAGAAGATGCAGCTGGGCTATCGGCTCCAGCAGATTGCAGCTGCTGTGGAA AACAAGGTCACAGATCTATAGGAACCCAGGAGCCACGGCCTGCTGTTGCTTCAGCCTGGCCTGGGCAGCCCTGGAAGCTCGGAGGAGAGG CCACCTTCTTAGGTGCCTGTAGTGACTGACAAGCAGAGTTAGTGGAAGGTGACTCCCAGTCTCCTGGTGGCTCTGGCCTCGGCCCTGCTG GATCCACCTCCTAGACCCGGGGCCTCAAGGCTCATGGGGTAGTACCCAGCCTGCTCCCCGAGTCCAGCGACCCTGTGACACCGGTCTGCA GGGAGTTGGGGACTAAGGGCTTCCAGAGAGTGGCTGGAAGAGACTCCAGGCCCCTGGGGAGACTGTACTGTTCCTGAACACTGGCCTTGG CCACACTGGGATTCGGAGAGGAAGGAGGAGAGCCCCATGCTTCCTGTCTGCCTCCTCCACCATCCCTGACCTCAGTTGAGCTGCCTCTGG CCTTGTTGCTGCTGCCACATCCTAGGTCTAAGAGTTGAACGCCTCTCCTAGGCCACTACAAACTGACCCCTCAGCAGGGCTGGCTGCCAC AGGGCTGCCCTGCCTCATAGGTAGCCATGGTGAGGGCTATCTGCTGCAGGGGGGTCTTGGGGAGAGTGGTGACTCCATTGACCCAGCTTT >8973_8973_1_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000296288_PLXNB1_chr3_48455480_ENST00000296440_length(amino acids)=1344AA_BP=612 MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNS CATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRL FELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGIKYEARLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKSA SNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLA AGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTS SGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVIS TGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKGENLDLAMSKEEVVAMIG DGPCVVKTLTRHHLYCEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLLALGVIIIVLMY RRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQ GLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWM SICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAK EKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRENQDYVPGERTP MLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQ AQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYARDIPRYKRMVER -------------------------------------------------------------- >8973_8973_2_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000296288_PLXNB1_chr3_48455480_ENST00000358459_length(transcript)=4702nt_BP=1872nt CCTGGACATGGCGCTGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTC GTGGAAGATTTCGGTGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTC CTGTTCAAATGGATCGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAAT AACATGTTCTTTGCCCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTG GGACCCACCCTGAGTCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCC AAGGCCCATAATAGCCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTC CACTTTGTCAGCTATGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAG GACGAGGAGTGGACAGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGATCAAGTATGAGGCCAGGCTGCAT GTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGCTGATAAGAGTAACACAGCCAGAGCTGATTCAGACCCACAAGTCT CAAGAGTCACAGCTGCCTGAGGAGTCCAAGTCAGCCAGCAACAAGTCCCCGCTGGTGCTGGAAGCAAACAGGGCCCCTGCAGCCTCTGAG GGCAACCACACAGATGGTGCAGAGGAGGCGGCTGGTTCATGCGCACAAGCCCCATCCCACAGCCCTCCCAACAAACCCAAGCTAGTGGTG AAGCCTCCAGGCAGCAGCCTCAATGGGGTTCACCCCAACCCCACTCCCATTGTCCAGCGGCTGCCGGCCTTTCTAGACAATCACAATTAT GCCAAGTCCCCCATGCAGGAGGAAGAAGACCTGGCGGCAGGTGTGGGCCGCAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTACTCAGAT GATGAGGATGACTATGAGGATGACGAGGAGGATGACGTGCAGAACACCAACTCTGCCCTTAGGTATAAGGGGAAGGGAACAGGGAAGCCA GGGGCATTGAGCGGTTCTGCTGATGGGCAACTGTCAGTGCTGCAGCCCAACACCATCAACGTCTTGGCTGAGAAGCTCAAAGAGTCCCAG AAGGACCTCTCAATTCCTCTGTCCATCAAGACTAGCAGCGGGGCTGGGAGTCCGGCTGTGGCAGTGCCCACACACTCGCAGCCCTCACCC ACCCCCAGCAATGAGAGTACAGACACGGCCTCTGAGATCGGCAGTGCTTTCAACTCGCCACTGCGCTCGCCTATCCGCTCAGCCAACCCG ACGCGGCCCTCCAGCCCTGTCACCTCCCACATCTCCAAGGTGCTTTTTGGAGAGGATGACAGCCTGCTGCGTGTTGACTGCATACGCTAC AACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGCCTGCTGCACCTGGCTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACA GAGGGTGGGAAGGGTTCCTCGCCCTCCATCAGACCAATCCAAGGCAGCCAGGGGTCCAGCAGCCCAGTGGAGAAGGAGGTCGTGGAAGCC ACGGACAGCAGAGAGAAGACGGGGATGGTGAGGCCTGGCGAGCCCTTGAGTGGGGAGAAATACTCACCCAAGGGGGAGAACCTGGACCTT GCAATGTCCAAGGAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGTGGTGAAGACGCTGACGCGGCACCACCTGTACTGCGAGCCC CCCGTGGAGCAGCCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGACTCTTTGCCTGAGTTCACGGTGCAGATGGGGAACTTGCGC TTCTCCCTGGGTCACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCCTGTGGCAGCCCAGGTGGGCTTGGGGGTGGGCACCTCTCTT CTGGCTCTGGGTGTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAAGCAGGCCCTGAGGGACTATAAGAAGGTTCAGATCCAGCTG GAGAATCTGGAGAGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGACCTCATGACTGAGATGACCGATCTCACCAGTGACCTCCTG GGCAGCGGCATCCCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTTCTTCCCTGGGCACCGCGAGTCGCCCTTGCACCGGGACCTG GGTGTGCCTGAGAGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCTCTCTAACCTGCTCAACAGCAAGCTCTTCCTCACCAAGTTC ATCCACACGCTGGAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTACGTGGCATCTCTGCTCACCGTGGCACTGCATGGGAAGCTT GAGTATTTCACTGACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCAGTATGTGGCCAAGAACCCCAAGCTGATGCTGCGCAGGACA GAGACTGTGGTGGAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTATACCTTCGTGAGGGACTCCGTAGGGGAGCCTCTGTACATG CTCTTTCGAGGGATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGTGACAGGCAAGGCCAAATACACCTTGAACGACAACCGCCTG CTCAGAGAGGATGTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGCTGTGGGGCCTGGGGCAGGAGAGGCCCAGGGCGTGCCCGTG AAGGTCCTAGACTGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGACCAGCTTTATAAAGGAGTGCCTCTCACCCAGCGGCCAGAC CCTCGCACCCTTGATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCATTCTTTCTGACGAGGATGTCACTTCTGAGGTCCAGGGTCTG TGGAGGCGCCTGAACACACTGCAGCATTACAAGGTCCCAGATGGAGCAACTGTGGCCCTCGTCCCCTGCCTCACCAAGCATGTGCTCCGG GAAAACCAGGATTATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGTAGATGAGGGGGGCATCCGGCCCTGGCACCTGGTGAAGCCA AGTGATGAGCCGGAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGGGGAGCGTGAGCGCGCCAAGGCCATCCCTGAGATCTACCTG ACCCGCCTGCTGTCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCTGTTCCAGGTGATTCTCAGCACCAGCCGCCCCGTGCCGCTC GCTGTGAAGTACTTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGGCATCTCCGACCAGGACACCATCCACATCTGGAAGACCAAC AGCTTGCCTCTGAGGTTCTGGATCAATATAATAAAAAACCCGCAGTTTGTGTTCGACGTGCAAACATCTGATAACATGGATGCGGTGCTC CTTGTCATTGCACAGACCTTCATGGACGCCTGCACCCTGGCCGACCACAAGCTGGGCCGGGACTCCCCGATCAACAAACTTCTGTATGCA CGGGACATTCCCCGGTACAAGCGGATGGTGGAAAGGTACTATGCAGACATCAGACAGACTGTCCCAGCCAGCGACCAAGAGATGAACTCT GTCCTGGCTGAACTGTCCTGGAACTACTCCGGAGACCTCGGGGCGCGAGTGGCCCTGCATGAACTCTACAAGTACATCAACAAGTACTAT GACCAGATCATCACTGCCCTGGAGGAGGATGGCACGGCCCAGAAGATGCAGCTGGGCTATCGGCTCCAGCAGATTGCAGCTGCTGTGGAA AACAAGGTCACAGATCTATAGGAACCCAGGAGCCACGGCCTGCTGTTGCTTCAGCCTGGCCTGGGCAGCCCTGGAAGCTCGGAGGAGAGG CCACCTTCTTAGGTGCCTGTAGTGACTGACAAGCAGAGTTAGTGGAAGGTGACTCCCAGTCTCCTGGTGGCTCTGGCCTCGGCCCTGCTG GATCCACCTCCTAGACCCGGGGCCTCAAGGCTCATGGGGTAGTACCCAGCCTGCTCCCCGAGTCCAGCGACCCTGTGACACCGGTCTGCA GGGAGTTGGGGACTAAGGGCTTCCAGAGAGTGGCTGGAAGAGACTCCAGGCCCCTGGGGAGACTGTACTGTTCCTGAACACTGGCCTTGG CCACACTGGGATTCGGAGAGGAAGGAGGAGAGCCCCATGCTTCCTGTCTGCCTCCTCCACCATCCCTGACCTCAGTTGAGCTGCCTCTGG CCTTGTTGCTGCTGCCACATCCTAGGTCTAAGAGTTGAACGCCTCTCCTAGGCCACTACAAACTGACCCCTCAGCAGGGCTGGCTGCCAC AGGGCTGCCCTGCCTCATAGGTAGCCATGGTGAGGGCTATCTGCTGCAGGGGGGTCTTGGGGAGAGTGGTGACTCCATTGACCCAGCTTT >8973_8973_2_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000296288_PLXNB1_chr3_48455480_ENST00000358459_length(amino acids)=1344AA_BP=612 MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNS CATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRL FELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGIKYEARLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKSA SNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLA AGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTS SGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVIS TGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKGENLDLAMSKEEVVAMIG DGPCVVKTLTRHHLYCEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLLALGVIIIVLMY RRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQ GLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWM SICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAK EKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRENQDYVPGERTP MLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQ AQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYARDIPRYKRMVER -------------------------------------------------------------- >8973_8973_3_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000296288_PLXNB1_chr3_48455480_ENST00000358536_length(transcript)=4701nt_BP=1872nt CCTGGACATGGCGCTGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTC GTGGAAGATTTCGGTGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTC CTGTTCAAATGGATCGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAAT AACATGTTCTTTGCCCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTG GGACCCACCCTGAGTCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCC AAGGCCCATAATAGCCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTC CACTTTGTCAGCTATGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAG GACGAGGAGTGGACAGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGATCAAGTATGAGGCCAGGCTGCAT GTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGCTGATAAGAGTAACACAGCCAGAGCTGATTCAGACCCACAAGTCT CAAGAGTCACAGCTGCCTGAGGAGTCCAAGTCAGCCAGCAACAAGTCCCCGCTGGTGCTGGAAGCAAACAGGGCCCCTGCAGCCTCTGAG GGCAACCACACAGATGGTGCAGAGGAGGCGGCTGGTTCATGCGCACAAGCCCCATCCCACAGCCCTCCCAACAAACCCAAGCTAGTGGTG AAGCCTCCAGGCAGCAGCCTCAATGGGGTTCACCCCAACCCCACTCCCATTGTCCAGCGGCTGCCGGCCTTTCTAGACAATCACAATTAT GCCAAGTCCCCCATGCAGGAGGAAGAAGACCTGGCGGCAGGTGTGGGCCGCAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTACTCAGAT GATGAGGATGACTATGAGGATGACGAGGAGGATGACGTGCAGAACACCAACTCTGCCCTTAGGTATAAGGGGAAGGGAACAGGGAAGCCA GGGGCATTGAGCGGTTCTGCTGATGGGCAACTGTCAGTGCTGCAGCCCAACACCATCAACGTCTTGGCTGAGAAGCTCAAAGAGTCCCAG AAGGACCTCTCAATTCCTCTGTCCATCAAGACTAGCAGCGGGGCTGGGAGTCCGGCTGTGGCAGTGCCCACACACTCGCAGCCCTCACCC ACCCCCAGCAATGAGAGTACAGACACGGCCTCTGAGATCGGCAGTGCTTTCAACTCGCCACTGCGCTCGCCTATCCGCTCAGCCAACCCG ACGCGGCCCTCCAGCCCTGTCACCTCCCACATCTCCAAGGTGCTTTTTGGAGAGGATGACAGCCTGCTGCGTGTTGACTGCATACGCTAC AACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGCCTGCTGCACCTGGCTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACA GAGGGTGGGAAGGGTTCCTCGCCCTCCATCAGACCAATCCAAGGCAGCCAGGGGTCCAGCAGCCCAGTGGAGAAGGAGGTCGTGGAAGCC ACGGACAGCAGAGAGAAGACGGGGATGGTGAGGCCTGGCGAGCCCTTGAGTGGGGAGAAATACTCACCCAAGGGGGAGAACCTGGACCTT GCAATGTCCAAGGAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGTGGTGAAGACGCTGACGCGGCACCACCTGTACTGCGAGCCC CCCGTGGAGCAGCCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGACTCTTTGCCTGAGTTCACGGTGCAGATGGGGAACTTGCGC TTCTCCCTGGGTCACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCCTGTGGCAGCCCAGGTGGGCTTGGGGGTGGGCACCTCTCTT CTGGCTCTGGGTGTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAAGCAGGCCCTGAGGGACTATAAGAAGGTTCAGATCCAGCTG GAGAATCTGGAGAGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGACCTCATGACTGAGATGACCGATCTCACCAGTGACCTCCTG GGCAGCGGCATCCCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTTCTTCCCTGGGCACCGCGAGTCGCCCTTGCACCGGGACCTG GGTGTGCCTGAGAGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCTCTCTAACCTGCTCAACAGCAAGCTCTTCCTCACCAAGTTC ATCCACACGCTGGAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTACGTGGCATCTCTGCTCACCGTGGCACTGCATGGGAAGCTT GAGTATTTCACTGACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCAGTATGTGGCCAAGAACCCCAAGCTGATGCTGCGCAGGACA GAGACTGTGGTGGAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTATACCTTCGTGAGGGACTCCGTAGGGGAGCCTCTGTACATG CTCTTTCGAGGGATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGTGACAGGCAAGGCCAAATACACCTTGAACGACAACCGCCTG CTCAGAGAGGATGTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGCTGTGGGGCCTGGGGCAGGAGAGGCCCAGGGCGTGCCCGTG AAGGTCCTAGACTGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGACCAGCTTTATAAAGGAGTGCCTCTCACCCAGCGGCCAGAC CCTCGCACCCTTGATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCATTCTTTCTGACGAGGATGTCACTTCTGAGGTCCAGGGTCTG TGGAGGCGCCTGAACACACTGCAGCATTACAAGGTCCCAGATGGAGCAACTGTGGCCCTCGTCCCCTGCCTCACCAAGCATGTGCTCCGG GAAAACCAGGATTATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGTAGATGAGGGGGGCATCCGGCCCTGGCACCTGGTGAAGCCA AGTGATGAGCCGGAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGGGGAGCGTGAGCGCGCCAAGGCCATCCCTGAGATCTACCTG ACCCGCCTGCTGTCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCTGTTCCAGGTGATTCTCAGCACCAGCCGCCCCGTGCCGCTC GCTGTGAAGTACTTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGGCATCTCCGACCAGGACACCATCCACATCTGGAAGACCAAC AGCTTGCCTCTGAGGTTCTGGATCAATATAATAAAAAACCCGCAGTTTGTGTTCGACGTGCAAACATCTGATAACATGGATGCGGTGCTC CTTGTCATTGCACAGACCTTCATGGACGCCTGCACCCTGGCCGACCACAAGCTGGGCCGGGACTCCCCGATCAACAAACTTCTGTATGCA CGGGACATTCCCCGGTACAAGCGGATGGTGGAAAGGTACTATGCAGACATCAGACAGACTGTCCCAGCCAGCGACCAAGAGATGAACTCT GTCCTGGCTGAACTGTCCTGGAACTACTCCGGAGACCTCGGGGCGCGAGTGGCCCTGCATGAACTCTACAAGTACATCAACAAGTACTAT GACCAGATCATCACTGCCCTGGAGGAGGATGGCACGGCCCAGAAGATGCAGCTGGGCTATCGGCTCCAGCAGATTGCAGCTGCTGTGGAA AACAAGGTCACAGATCTATAGGAACCCAGGAGCCACGGCCTGCTGTTGCTTCAGCCTGGCCTGGGCAGCCCTGGAAGCTCGGAGGAGAGG CCACCTTCTTAGGTGCCTGTAGTGACTGACAAGCAGAGTTAGTGGAAGGTGACTCCCAGTCTCCTGGTGGCTCTGGCCTCGGCCCTGCTG GATCCACCTCCTAGACCCGGGGCCTCAAGGCTCATGGGGTAGTACCCAGCCTGCTCCCCGAGTCCAGCGACCCTGTGACACCGGTCTGCA GGGAGTTGGGGACTAAGGGCTTCCAGAGAGTGGCTGGAAGAGACTCCAGGCCCCTGGGGAGACTGTACTGTTCCTGAACACTGGCCTTGG CCACACTGGGATTCGGAGAGGAAGGAGGAGAGCCCCATGCTTCCTGTCTGCCTCCTCCACCATCCCTGACCTCAGTTGAGCTGCCTCTGG CCTTGTTGCTGCTGCCACATCCTAGGTCTAAGAGTTGAACGCCTCTCCTAGGCCACTACAAACTGACCCCTCAGCAGGGCTGGCTGCCAC AGGGCTGCCCTGCCTCATAGGTAGCCATGGTGAGGGCTATCTGCTGCAGGGGGGTCTTGGGGAGAGTGGTGACTCCATTGACCCAGCTTT >8973_8973_3_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000296288_PLXNB1_chr3_48455480_ENST00000358536_length(amino acids)=1344AA_BP=612 MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNS CATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRL FELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGIKYEARLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKSA SNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLA AGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTS SGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVIS TGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKGENLDLAMSKEEVVAMIG DGPCVVKTLTRHHLYCEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLLALGVIIIVLMY RRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQ GLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWM SICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAK EKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRENQDYVPGERTP MLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQ AQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYARDIPRYKRMVER -------------------------------------------------------------- >8973_8973_4_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000296288_PLXNB1_chr3_48455480_ENST00000448774_length(transcript)=4112nt_BP=1872nt CCTGGACATGGCGCTGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTC GTGGAAGATTTCGGTGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTC CTGTTCAAATGGATCGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAAT AACATGTTCTTTGCCCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTG GGACCCACCCTGAGTCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCC AAGGCCCATAATAGCCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTC CACTTTGTCAGCTATGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAG GACGAGGAGTGGACAGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGATCAAGTATGAGGCCAGGCTGCAT GTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGCTGATAAGAGTAACACAGCCAGAGCTGATTCAGACCCACAAGTCT CAAGAGTCACAGCTGCCTGAGGAGTCCAAGTCAGCCAGCAACAAGTCCCCGCTGGTGCTGGAAGCAAACAGGGCCCCTGCAGCCTCTGAG GGCAACCACACAGATGGTGCAGAGGAGGCGGCTGGTTCATGCGCACAAGCCCCATCCCACAGCCCTCCCAACAAACCCAAGCTAGTGGTG AAGCCTCCAGGCAGCAGCCTCAATGGGGTTCACCCCAACCCCACTCCCATTGTCCAGCGGCTGCCGGCCTTTCTAGACAATCACAATTAT GCCAAGTCCCCCATGCAGGAGGAAGAAGACCTGGCGGCAGGTGTGGGCCGCAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTACTCAGAT GATGAGGATGACTATGAGGATGACGAGGAGGATGACGTGCAGAACACCAACTCTGCCCTTAGGTATAAGGGGAAGGGAACAGGGAAGCCA GGGGCATTGAGCGGTTCTGCTGATGGGCAACTGTCAGTGCTGCAGCCCAACACCATCAACGTCTTGGCTGAGAAGCTCAAAGAGTCCCAG AAGGACCTCTCAATTCCTCTGTCCATCAAGACTAGCAGCGGGGCTGGGAGTCCGGCTGTGGCAGTGCCCACACACTCGCAGCCCTCACCC ACCCCCAGCAATGAGAGTACAGACACGGCCTCTGAGATCGGCAGTGCTTTCAACTCGCCACTGCGCTCGCCTATCCGCTCAGCCAACCCG ACGCGGCCCTCCAGCCCTGTCACCTCCCACATCTCCAAGGTGCTTTTTGGAGAGGATGACAGCCTGCTGCGTGTTGACTGCATACGCTAC AACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGCCTGCTGCACCTGGCTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACA GAGGGTGGGAAGGGTTCCTCGCCCTCCATCAGACCAATCCAAGGCAGCCAGGGGTCCAGCAGCCCAGTGGAGAAGGAGGTCGTGGAAGCC ACGGACAGCAGAGAGAAGACGGGGATGGTGAGGCCTGGCGAGCCCTTGAGTGGGGAGAAATACTCACCCAAGGGGGAGAACCTGGACCTT GCAATGTCCAAGGAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGTGGTGAAGACGCTGACGCGGCACCACCTGTACTGCGAGCCC CCCGTGGAGCAGCCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGACTCTTTGCCTGAGTTCACGGTGCAGATGGGGAACTTGCGC TTCTCCCTGGGTCACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCCTGTGGCAGCCCAGGTGGGCTTGGGGGTGGGCACCTCTCTT CTGGCTCTGGGTGTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAAGCAGGCCCTGAGGGACTATAAGAAGGTTCAGATCCAGCTG GAGAATCTGGAGAGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGACCTCATGACTGAGATGACCGATCTCACCAGTGACCTCCTG GGCAGCGGCATCCCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTTCTTCCCTGGGCACCGCGAGTCGCCCTTGCACCGGGACCTG GGTGTGCCTGAGAGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCTCTCTAACCTGCTCAACAGCAAGCTCTTCCTCACCAAGTTC ATCCACACGCTGGAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTACGTGGCATCTCTGCTCACCGTGGCACTGCATGGGAAGCTT GAGTATTTCACTGACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCAGTATGTGGCCAAGAACCCCAAGCTGATGCTGCGCAGGACA GAGACTGTGGTGGAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTATACCTTCGTGAGGGACTCCGTAGGGGAGCCTCTGTACATG CTCTTTCGAGGGATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGTGACAGGCAAGGCCAAATACACCTTGAACGACAACCGCCTG CTCAGAGAGGATGTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGCTGTGGGGCCTGGGGCAGGAGAGGCCCAGGGCGTGCCCGTG AAGGTCCTAGACTGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGACCAGCTTTATAAAGGAGTGCCTCTCACCCAGCGGCCAGAC CCTCGCACCCTTGATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCATTCTTTCTGACGAGGATGTCACTTCTGAGGTCCAGGGTCTG TGGAGGCGCCTGAACACACTGCAGCATTACAAGGTCCCAGATGGAGCAACTGTGGCCCTCGTCCCCTGCCTCACCAAGCATGTGCTCCGG GAAAACCAGGATTATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGTAGATGAGGGGGGCATCCGGCCCTGGCACCTGGTGAAGCCA AGTGATGAGCCGGAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGGGGAGCGTGAGCGCGCCAAGGCCATCCCTGAGATCTACCTG ACCCGCCTGCTGTCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCTGTTCCAGGTGATTCTCAGCACCAGCCGCCCCGTGCCGCTC GCTGTGAAGTACTTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGGCATCTCCGACCAGGACACCATCCACATCTGGAAGACCAAC AGCTTGCCTCTGAGGTTCTGGATCAATATAATAAAAAACCCGCAGTTTGTGTTCGACGTGCAAACATCTGATAACATGGATGCGGTGCTC CTTGTCATTGCACAGACCTTCATGGACGCCTGCACCCTGGCCGACCACAAGCTGGGCCGGGACTCCCCGATCAACAAACTTCTGTATGCA CGGGACATTCCCCGGTACAAGCGGATGGTGGAAAGGTACTATGCAGACATCAGACAGACTGTCCCAGCCAGCGACCAAGAGATGAACTCT GTCCTGGCTGAACTGTCCTGGAACTACTCCGGAGACCTCGGGGCGCGAGTGGCCCTGCATGAACTCTACAAGTACATCAACAAGTACTAT GACCAGATCATCACTGCCCTGGAGGAGGATGGCACGGCCCAGAAGATGCAGCTGGGCTATCGGCTCCAGCAGATTGCAGCTGCTGTGGAA >8973_8973_4_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000296288_PLXNB1_chr3_48455480_ENST00000448774_length(amino acids)=1344AA_BP=612 MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNS CATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRL FELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGIKYEARLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKSA SNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLA AGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTS SGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVIS TGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKGENLDLAMSKEEVVAMIG DGPCVVKTLTRHHLYCEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLLALGVIIIVLMY RRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQ GLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWM SICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAK EKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRENQDYVPGERTP MLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQ AQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYARDIPRYKRMVER -------------------------------------------------------------- >8973_8973_5_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000296288_PLXNB1_chr3_48455480_ENST00000456774_length(transcript)=4071nt_BP=1872nt CCTGGACATGGCGCTGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTC GTGGAAGATTTCGGTGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTC CTGTTCAAATGGATCGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAAT AACATGTTCTTTGCCCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTG GGACCCACCCTGAGTCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCC AAGGCCCATAATAGCCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTC CACTTTGTCAGCTATGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAG GACGAGGAGTGGACAGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGATCAAGTATGAGGCCAGGCTGCAT GTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGCTGATAAGAGTAACACAGCCAGAGCTGATTCAGACCCACAAGTCT CAAGAGTCACAGCTGCCTGAGGAGTCCAAGTCAGCCAGCAACAAGTCCCCGCTGGTGCTGGAAGCAAACAGGGCCCCTGCAGCCTCTGAG GGCAACCACACAGATGGTGCAGAGGAGGCGGCTGGTTCATGCGCACAAGCCCCATCCCACAGCCCTCCCAACAAACCCAAGCTAGTGGTG AAGCCTCCAGGCAGCAGCCTCAATGGGGTTCACCCCAACCCCACTCCCATTGTCCAGCGGCTGCCGGCCTTTCTAGACAATCACAATTAT GCCAAGTCCCCCATGCAGGAGGAAGAAGACCTGGCGGCAGGTGTGGGCCGCAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTACTCAGAT GATGAGGATGACTATGAGGATGACGAGGAGGATGACGTGCAGAACACCAACTCTGCCCTTAGGTATAAGGGGAAGGGAACAGGGAAGCCA GGGGCATTGAGCGGTTCTGCTGATGGGCAACTGTCAGTGCTGCAGCCCAACACCATCAACGTCTTGGCTGAGAAGCTCAAAGAGTCCCAG AAGGACCTCTCAATTCCTCTGTCCATCAAGACTAGCAGCGGGGCTGGGAGTCCGGCTGTGGCAGTGCCCACACACTCGCAGCCCTCACCC ACCCCCAGCAATGAGAGTACAGACACGGCCTCTGAGATCGGCAGTGCTTTCAACTCGCCACTGCGCTCGCCTATCCGCTCAGCCAACCCG ACGCGGCCCTCCAGCCCTGTCACCTCCCACATCTCCAAGGTGCTTTTTGGAGAGGATGACAGCCTGCTGCGTGTTGACTGCATACGCTAC AACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGCCTGCTGCACCTGGCTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACA GAGGGTGGGAAGGGTTCCTCGCCCTCCATCAGACCAATCCAAGGCAGCCAGGGGTCCAGCAGCCCAGTGGAGAAGGAGGTCGTGGAAGCC ACGGACAGCAGAGAGAAGACGGGGATGGTGAGGCCTGGCGAGCCCTTGAGTGGGGAGAAATACTCACCCAAGGGGGAGAACCTGGACCTT GCAATGTCCAAGGAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGTGGTGAAGACGCTGACGCGGCACCACCTGTACTGCGAGCCC CCCGTGGAGCAGCCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGACTCTTTGCCTGAGTTCACGGTGCAGATGGGGAACTTGCGC TTCTCCCTGGGTCACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCCTGTGGCAGCCCAGGTGGGCTTGGGGGTGGGCACCTCTCTT CTGGCTCTGGGTGTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAAGCAGGCCCTGAGGGACTATAAGAAGGTTCAGATCCAGCTG GAGAATCTGGAGAGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGACCTCATGACTGAGATGACCGATCTCACCAGTGACCTCCTG GGCAGCGGCATCCCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTTCTTCCCTGGGCACCGCGAGTCGCCCTTGCACCGGGACCTG GGTGTGCCTGAGAGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCTCTCTAACCTGCTCAACAGCAAGCTCTTCCTCACCAAGTTC ATCCACACGCTGGAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTACGTGGCATCTCTGCTCACCGTGGCACTGCATGGGAAGCTT GAGTATTTCACTGACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCAGTATGTGGCCAAGAACCCCAAGCTGATGCTGCGCAGGACA GAGACTGTGGTGGAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTATACCTTCGTGAGGGACTCCGTAGGGGAGCCTCTGTACATG CTCTTTCGAGGGATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGTGACAGGCAAGGCCAAATACACCTTGAACGACAACCGCCTG CTCAGAGAGGATGTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGCTGTGGGGCCTGGGGCAGGAGAGGCCCAGGGCGTGCCCGTG AAGGTCCTAGACTGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGACCAGCTTTATAAAGGAGTGCCTCTCACCCAGCGGCCAGAC CCTCGCACCCTTGATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCATTCTTTCTGACGAGGATGTCACTTCTGAGGTCCAGGGTCTG TGGAGGCGCCTGAACACACTGCAGCATTACAAGGTCCCAGATGGAGCAACTGTGGCCCTCGTCCCCTGCCTCACCAAGCATGTGCTCCGG GAAAACCAGGATTATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGTAGATGAGGGGGGCATCCGGCCCTGGCACCTGGTGAAGCCA AGTGATGAGCCGGAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGGGGAGCGTGAGCGCGCCAAGGCCATCCCTGAGATCTACCTG ACCCGCCTGCTGTCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCTGTTCCAGGTGATTCTCAGCACCAGCCGCCCCGTGCCGCTC GCTGTGAAGTACTTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGGCATCTCCGACCAGGACACCATCCACATCTGGAAGACCAAC AGCTTGCCTCTGAGGTTCTGGATCAATATAATAAAAAACCCGCAGTTTGTGTTCGACGTGCAAACATCTGATAACATGGATGCGGTGCTC CTTGTCATTGCACAGACCTTCATGGACGCCTGCACCCTGGCCGACCACAAGCTGGGCCGGGACTCCCCGATCAACAAACTTCTGTATGCA CGGGACATTCCCCGGTACAAGCGGATGGTGGAAAGGTACTATGCAGACATCAGACAGACTGTCCCAGCCAGCGACCAAGAGATGAACTCT GTCCTGGCTGAACTGTCCTGGAACTACTCCGGAGACCTCGGGGCGCGAGTGGCCCTGCATGAACTCTACAAGTACATCAACAAGTACTAT GACCAGATCATCACTGCCCTGGAGGAGGATGGCACGGCCCAGAAGATGCAGCTGGGCTATCGGCTCCAGCAGATTGCAGCTGCTGTGGAA >8973_8973_5_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000296288_PLXNB1_chr3_48455480_ENST00000456774_length(amino acids)=1344AA_BP=612 MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNS CATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRL FELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGIKYEARLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKSA SNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLA AGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTS SGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVIS TGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKGENLDLAMSKEEVVAMIG DGPCVVKTLTRHHLYCEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLLALGVIIIVLMY RRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQ GLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWM SICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAK EKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRENQDYVPGERTP MLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQ AQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYARDIPRYKRMVER -------------------------------------------------------------- >8973_8973_6_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000460680_PLXNB1_chr3_48455480_ENST00000296440_length(transcript)=5193nt_BP=2362nt CGCTCCGCCCCTCCCCTCGCAGCACCCGGGCCTAGTACTGCCCGTCCCGCCCCTCCTCTCGAGCCTCAGCGCTCAGCATCGCCCGGACCC CCTCTTCCCTTCGCCCGCCTCGTCCCGACCCTCCCCTTCGCCCCCGTCCCGCCCCGCCCCTCCCCTTCGCCCCCGTCCCGTCCCGCCCCG CCCCTCCCCTTCGCCCCCGTCCCTCCCCTTCGCCCCCGTCCCTCCGCGCGTGCGCGTTCGCCTTCGAGCGCATGCCCGCATCTGCTGTCC GACAGGCGGAAGACGAGCCCAGAGGCGGAGCAGGGCCGTCGCGCCTTGGTGACGTCTGCCGCCGGCGCGGGCGGGTGACGCGACTGGGCC CGTTGTCTGTGTGTGGGACTGAGGGGCCCCGGGGGCGGTGGGGGCTCCCGGTGGGGGCAGCGGTGGGGAGGGAGGGCCTGGACATGGCGC TGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTCGTGGAAGATTTCGG TGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTCCTGTTCAAATGGAT CGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAATAACATGTTCTTTGC CCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTGGGACCCACCCTGAG TCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCCAAGGCCCATAATAG CCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTCCACTTTGTCAGCTA TGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAGGACGAGGAGTGGAC AGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGGAGCCCTACCACGACATCCGCTTCAACCTGATGGCAGT GGTGCCCGACCGCAGGATCAAGTATGAGGCCAGGCTGCATGTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGCTGAT AAGAGTAACACAGCCAGAGCTGATTCAGACCCACAAGTCTCAAGAGTCACAGCTGCCTGAGGAGTCCAAGTCAGCCAGCAACAAGTCCCC GCTGGTGCTGGAAGCAAACAGGGCCCCTGCAGCCTCTGAGGGCAACCACACAGATGGTGCAGAGGAGGCGGCTGGTTCATGCGCACAAGC CCCATCCCACAGCCCTCCCAACAAACCCAAGCTAGTGGTGAAGCCTCCAGGCAGCAGCCTCAATGGGGTTCACCCCAACCCCACTCCCAT TGTCCAGCGGCTGCCGGCCTTTCTAGACAATCACAATTATGCCAAGTCCCCCATGCAGGAGGAAGAAGACCTGGCGGCAGGTGTGGGCCG CAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTACTCAGATGATGAGGATGACTATGAGGATGACGAGGAGGATGACGTGCAGAACACCAA CTCTGCCCTTAGGTATAAGGGGAAGGGAACAGGGAAGCCAGGGGCATTGAGCGGTTCTGCTGATGGGCAACTGTCAGTGCTGCAGCCCAA CACCATCAACGTCTTGGCTGAGAAGCTCAAAGAGTCCCAGAAGGACCTCTCAATTCCTCTGTCCATCAAGACTAGCAGCGGGGCTGGGAG TCCGGCTGTGGCAGTGCCCACACACTCGCAGCCCTCACCCACCCCCAGCAATGAGAGTACAGACACGGCCTCTGAGATCGGCAGTGCTTT CAACTCGCCACTGCGCTCGCCTATCCGCTCAGCCAACCCGACGCGGCCCTCCAGCCCTGTCACCTCCCACATCTCCAAGGTGCTTTTTGG AGAGGATGACAGCCTGCTGCGTGTTGACTGCATACGCTACAACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGCCTGCTGCA CCTGGCTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACAGAGGGTGGGAAGGGTTCCTCGCCCTCCATCAGACCAATCCAAGGCAGCCA GGGGTCCAGCAGCCCAGTGGAGAAGGAGGTCGTGGAAGCCACGGACAGCAGAGAGAAGACGGGGATGGTGAGGCCTGGCGAGCCCTTGAG TGGGGAGAAATACTCACCCAAGGGGGAGAACCTGGACCTTGCAATGTCCAAGGAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGT GGTGAAGACGCTGACGCGGCACCACCTGTACTGCGAGCCCCCCGTGGAGCAGCCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGA CTCTTTGCCTGAGTTCACGGTGCAGATGGGGAACTTGCGCTTCTCCCTGGGTCACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCC TGTGGCAGCCCAGGTGGGCTTGGGGGTGGGCACCTCTCTTCTGGCTCTGGGTGTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAA GCAGGCCCTGAGGGACTATAAGAAGGTTCAGATCCAGCTGGAGAATCTGGAGAGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGA CCTCATGACTGAGATGACCGATCTCACCAGTGACCTCCTGGGCAGCGGCATCCCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTT CTTCCCTGGGCACCGCGAGTCGCCCTTGCACCGGGACCTGGGTGTGCCTGAGAGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCT CTCTAACCTGCTCAACAGCAAGCTCTTCCTCACCAAGTTCATCCACACGCTGGAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTA CGTGGCATCTCTGCTCACCGTGGCACTGCATGGGAAGCTTGAGTATTTCACTGACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCA GTATGTGGCCAAGAACCCCAAGCTGATGCTGCGCAGGACAGAGACTGTGGTGGAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTA TACCTTCGTGAGGGACTCCGTAGGGGAGCCTCTGTACATGCTCTTTCGAGGGATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGT GACAGGCAAGGCCAAATACACCTTGAACGACAACCGCCTGCTCAGAGAGGATGTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGC TGTGGGGCCTGGGGCAGGAGAGGCCCAGGGCGTGCCCGTGAAGGTCCTAGACTGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGA CCAGCTTTATAAAGGAGTGCCTCTCACCCAGCGGCCAGACCCTCGCACCCTTGATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCAT TCTTTCTGACGAGGATGTCACTTCTGAGGTCCAGGGTCTGTGGAGGCGCCTGAACACACTGCAGCATTACAAGGTCCCAGATGGAGCAAC TGTGGCCCTCGTCCCCTGCCTCACCAAGCATGTGCTCCGGGAAAACCAGGATTATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGT AGATGAGGGGGGCATCCGGCCCTGGCACCTGGTGAAGCCAAGTGATGAGCCGGAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGG GGAGCGTGAGCGCGCCAAGGCCATCCCTGAGATCTACCTGACCCGCCTGCTGTCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCT GTTCCAGGTGATTCTCAGCACCAGCCGCCCCGTGCCGCTCGCTGTGAAGTACTTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGG CATCTCCGACCAGGACACCATCCACATCTGGAAGACCAACAGCTTGCCTCTGAGGTTCTGGATCAATATAATAAAAAACCCGCAGTTTGT GTTCGACGTGCAAACATCTGATAACATGGATGCGGTGCTCCTTGTCATTGCACAGACCTTCATGGACGCCTGCACCCTGGCCGACCACAA GCTGGGCCGGGACTCCCCGATCAACAAACTTCTGTATGCACGGGACATTCCCCGGTACAAGCGGATGGTGGAAAGGTACTATGCAGACAT CAGACAGACTGTCCCAGCCAGCGACCAAGAGATGAACTCTGTCCTGGCTGAACTGTCCTGGAACTACTCCGGAGACCTCGGGGCGCGAGT GGCCCTGCATGAACTCTACAAGTACATCAACAAGTACTATGACCAGATCATCACTGCCCTGGAGGAGGATGGCACGGCCCAGAAGATGCA GCTGGGCTATCGGCTCCAGCAGATTGCAGCTGCTGTGGAAAACAAGGTCACAGATCTATAGGAACCCAGGAGCCACGGCCTGCTGTTGCT TCAGCCTGGCCTGGGCAGCCCTGGAAGCTCGGAGGAGAGGCCACCTTCTTAGGTGCCTGTAGTGACTGACAAGCAGAGTTAGTGGAAGGT GACTCCCAGTCTCCTGGTGGCTCTGGCCTCGGCCCTGCTGGATCCACCTCCTAGACCCGGGGCCTCAAGGCTCATGGGGTAGTACCCAGC CTGCTCCCCGAGTCCAGCGACCCTGTGACACCGGTCTGCAGGGAGTTGGGGACTAAGGGCTTCCAGAGAGTGGCTGGAAGAGACTCCAGG CCCCTGGGGAGACTGTACTGTTCCTGAACACTGGCCTTGGCCACACTGGGATTCGGAGAGGAAGGAGGAGAGCCCCATGCTTCCTGTCTG CCTCCTCCACCATCCCTGACCTCAGTTGAGCTGCCTCTGGCCTTGTTGCTGCTGCCACATCCTAGGTCTAAGAGTTGAACGCCTCTCCTA GGCCACTACAAACTGACCCCTCAGCAGGGCTGGCTGCCACAGGGCTGCCCTGCCTCATAGGTAGCCATGGTGAGGGCTATCTGCTGCAGG >8973_8973_6_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000460680_PLXNB1_chr3_48455480_ENST00000296440_length(amino acids)=1362AA_BP=630 MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNS CATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRL FELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEALQQLIRVTQPEL IQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAF LDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAE KLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLR VDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPK GENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGL GVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRES PLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPK LMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGE AQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCL TKHVLRENQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST SRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPI NKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQ -------------------------------------------------------------- >8973_8973_7_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000460680_PLXNB1_chr3_48455480_ENST00000358459_length(transcript)=5192nt_BP=2362nt CGCTCCGCCCCTCCCCTCGCAGCACCCGGGCCTAGTACTGCCCGTCCCGCCCCTCCTCTCGAGCCTCAGCGCTCAGCATCGCCCGGACCC CCTCTTCCCTTCGCCCGCCTCGTCCCGACCCTCCCCTTCGCCCCCGTCCCGCCCCGCCCCTCCCCTTCGCCCCCGTCCCGTCCCGCCCCG CCCCTCCCCTTCGCCCCCGTCCCTCCCCTTCGCCCCCGTCCCTCCGCGCGTGCGCGTTCGCCTTCGAGCGCATGCCCGCATCTGCTGTCC GACAGGCGGAAGACGAGCCCAGAGGCGGAGCAGGGCCGTCGCGCCTTGGTGACGTCTGCCGCCGGCGCGGGCGGGTGACGCGACTGGGCC CGTTGTCTGTGTGTGGGACTGAGGGGCCCCGGGGGCGGTGGGGGCTCCCGGTGGGGGCAGCGGTGGGGAGGGAGGGCCTGGACATGGCGC TGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTCGTGGAAGATTTCGG TGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTCCTGTTCAAATGGAT CGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAATAACATGTTCTTTGC CCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTGGGACCCACCCTGAG TCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCCAAGGCCCATAATAG CCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTCCACTTTGTCAGCTA TGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAGGACGAGGAGTGGAC AGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGGAGCCCTACCACGACATCCGCTTCAACCTGATGGCAGT GGTGCCCGACCGCAGGATCAAGTATGAGGCCAGGCTGCATGTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGCTGAT AAGAGTAACACAGCCAGAGCTGATTCAGACCCACAAGTCTCAAGAGTCACAGCTGCCTGAGGAGTCCAAGTCAGCCAGCAACAAGTCCCC GCTGGTGCTGGAAGCAAACAGGGCCCCTGCAGCCTCTGAGGGCAACCACACAGATGGTGCAGAGGAGGCGGCTGGTTCATGCGCACAAGC CCCATCCCACAGCCCTCCCAACAAACCCAAGCTAGTGGTGAAGCCTCCAGGCAGCAGCCTCAATGGGGTTCACCCCAACCCCACTCCCAT TGTCCAGCGGCTGCCGGCCTTTCTAGACAATCACAATTATGCCAAGTCCCCCATGCAGGAGGAAGAAGACCTGGCGGCAGGTGTGGGCCG CAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTACTCAGATGATGAGGATGACTATGAGGATGACGAGGAGGATGACGTGCAGAACACCAA CTCTGCCCTTAGGTATAAGGGGAAGGGAACAGGGAAGCCAGGGGCATTGAGCGGTTCTGCTGATGGGCAACTGTCAGTGCTGCAGCCCAA CACCATCAACGTCTTGGCTGAGAAGCTCAAAGAGTCCCAGAAGGACCTCTCAATTCCTCTGTCCATCAAGACTAGCAGCGGGGCTGGGAG TCCGGCTGTGGCAGTGCCCACACACTCGCAGCCCTCACCCACCCCCAGCAATGAGAGTACAGACACGGCCTCTGAGATCGGCAGTGCTTT CAACTCGCCACTGCGCTCGCCTATCCGCTCAGCCAACCCGACGCGGCCCTCCAGCCCTGTCACCTCCCACATCTCCAAGGTGCTTTTTGG AGAGGATGACAGCCTGCTGCGTGTTGACTGCATACGCTACAACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGCCTGCTGCA CCTGGCTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACAGAGGGTGGGAAGGGTTCCTCGCCCTCCATCAGACCAATCCAAGGCAGCCA GGGGTCCAGCAGCCCAGTGGAGAAGGAGGTCGTGGAAGCCACGGACAGCAGAGAGAAGACGGGGATGGTGAGGCCTGGCGAGCCCTTGAG TGGGGAGAAATACTCACCCAAGGGGGAGAACCTGGACCTTGCAATGTCCAAGGAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGT GGTGAAGACGCTGACGCGGCACCACCTGTACTGCGAGCCCCCCGTGGAGCAGCCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGA CTCTTTGCCTGAGTTCACGGTGCAGATGGGGAACTTGCGCTTCTCCCTGGGTCACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCC TGTGGCAGCCCAGGTGGGCTTGGGGGTGGGCACCTCTCTTCTGGCTCTGGGTGTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAA GCAGGCCCTGAGGGACTATAAGAAGGTTCAGATCCAGCTGGAGAATCTGGAGAGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGA CCTCATGACTGAGATGACCGATCTCACCAGTGACCTCCTGGGCAGCGGCATCCCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTT CTTCCCTGGGCACCGCGAGTCGCCCTTGCACCGGGACCTGGGTGTGCCTGAGAGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCT CTCTAACCTGCTCAACAGCAAGCTCTTCCTCACCAAGTTCATCCACACGCTGGAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTA CGTGGCATCTCTGCTCACCGTGGCACTGCATGGGAAGCTTGAGTATTTCACTGACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCA GTATGTGGCCAAGAACCCCAAGCTGATGCTGCGCAGGACAGAGACTGTGGTGGAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTA TACCTTCGTGAGGGACTCCGTAGGGGAGCCTCTGTACATGCTCTTTCGAGGGATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGT GACAGGCAAGGCCAAATACACCTTGAACGACAACCGCCTGCTCAGAGAGGATGTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGC TGTGGGGCCTGGGGCAGGAGAGGCCCAGGGCGTGCCCGTGAAGGTCCTAGACTGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGA CCAGCTTTATAAAGGAGTGCCTCTCACCCAGCGGCCAGACCCTCGCACCCTTGATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCAT TCTTTCTGACGAGGATGTCACTTCTGAGGTCCAGGGTCTGTGGAGGCGCCTGAACACACTGCAGCATTACAAGGTCCCAGATGGAGCAAC TGTGGCCCTCGTCCCCTGCCTCACCAAGCATGTGCTCCGGGAAAACCAGGATTATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGT AGATGAGGGGGGCATCCGGCCCTGGCACCTGGTGAAGCCAAGTGATGAGCCGGAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGG GGAGCGTGAGCGCGCCAAGGCCATCCCTGAGATCTACCTGACCCGCCTGCTGTCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCT GTTCCAGGTGATTCTCAGCACCAGCCGCCCCGTGCCGCTCGCTGTGAAGTACTTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGG CATCTCCGACCAGGACACCATCCACATCTGGAAGACCAACAGCTTGCCTCTGAGGTTCTGGATCAATATAATAAAAAACCCGCAGTTTGT GTTCGACGTGCAAACATCTGATAACATGGATGCGGTGCTCCTTGTCATTGCACAGACCTTCATGGACGCCTGCACCCTGGCCGACCACAA GCTGGGCCGGGACTCCCCGATCAACAAACTTCTGTATGCACGGGACATTCCCCGGTACAAGCGGATGGTGGAAAGGTACTATGCAGACAT CAGACAGACTGTCCCAGCCAGCGACCAAGAGATGAACTCTGTCCTGGCTGAACTGTCCTGGAACTACTCCGGAGACCTCGGGGCGCGAGT GGCCCTGCATGAACTCTACAAGTACATCAACAAGTACTATGACCAGATCATCACTGCCCTGGAGGAGGATGGCACGGCCCAGAAGATGCA GCTGGGCTATCGGCTCCAGCAGATTGCAGCTGCTGTGGAAAACAAGGTCACAGATCTATAGGAACCCAGGAGCCACGGCCTGCTGTTGCT TCAGCCTGGCCTGGGCAGCCCTGGAAGCTCGGAGGAGAGGCCACCTTCTTAGGTGCCTGTAGTGACTGACAAGCAGAGTTAGTGGAAGGT GACTCCCAGTCTCCTGGTGGCTCTGGCCTCGGCCCTGCTGGATCCACCTCCTAGACCCGGGGCCTCAAGGCTCATGGGGTAGTACCCAGC CTGCTCCCCGAGTCCAGCGACCCTGTGACACCGGTCTGCAGGGAGTTGGGGACTAAGGGCTTCCAGAGAGTGGCTGGAAGAGACTCCAGG CCCCTGGGGAGACTGTACTGTTCCTGAACACTGGCCTTGGCCACACTGGGATTCGGAGAGGAAGGAGGAGAGCCCCATGCTTCCTGTCTG CCTCCTCCACCATCCCTGACCTCAGTTGAGCTGCCTCTGGCCTTGTTGCTGCTGCCACATCCTAGGTCTAAGAGTTGAACGCCTCTCCTA GGCCACTACAAACTGACCCCTCAGCAGGGCTGGCTGCCACAGGGCTGCCCTGCCTCATAGGTAGCCATGGTGAGGGCTATCTGCTGCAGG >8973_8973_7_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000460680_PLXNB1_chr3_48455480_ENST00000358459_length(amino acids)=1362AA_BP=630 MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNS CATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRL FELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEALQQLIRVTQPEL IQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAF LDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAE KLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLR VDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPK GENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGL GVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRES PLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPK LMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGE AQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCL TKHVLRENQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST SRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPI NKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQ -------------------------------------------------------------- >8973_8973_8_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000460680_PLXNB1_chr3_48455480_ENST00000358536_length(transcript)=5191nt_BP=2362nt CGCTCCGCCCCTCCCCTCGCAGCACCCGGGCCTAGTACTGCCCGTCCCGCCCCTCCTCTCGAGCCTCAGCGCTCAGCATCGCCCGGACCC CCTCTTCCCTTCGCCCGCCTCGTCCCGACCCTCCCCTTCGCCCCCGTCCCGCCCCGCCCCTCCCCTTCGCCCCCGTCCCGTCCCGCCCCG CCCCTCCCCTTCGCCCCCGTCCCTCCCCTTCGCCCCCGTCCCTCCGCGCGTGCGCGTTCGCCTTCGAGCGCATGCCCGCATCTGCTGTCC GACAGGCGGAAGACGAGCCCAGAGGCGGAGCAGGGCCGTCGCGCCTTGGTGACGTCTGCCGCCGGCGCGGGCGGGTGACGCGACTGGGCC CGTTGTCTGTGTGTGGGACTGAGGGGCCCCGGGGGCGGTGGGGGCTCCCGGTGGGGGCAGCGGTGGGGAGGGAGGGCCTGGACATGGCGC TGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTCGTGGAAGATTTCGG TGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTCCTGTTCAAATGGAT CGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAATAACATGTTCTTTGC CCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTGGGACCCACCCTGAG TCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCCAAGGCCCATAATAG CCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTCCACTTTGTCAGCTA TGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAGGACGAGGAGTGGAC AGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGGAGCCCTACCACGACATCCGCTTCAACCTGATGGCAGT GGTGCCCGACCGCAGGATCAAGTATGAGGCCAGGCTGCATGTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGCTGAT AAGAGTAACACAGCCAGAGCTGATTCAGACCCACAAGTCTCAAGAGTCACAGCTGCCTGAGGAGTCCAAGTCAGCCAGCAACAAGTCCCC GCTGGTGCTGGAAGCAAACAGGGCCCCTGCAGCCTCTGAGGGCAACCACACAGATGGTGCAGAGGAGGCGGCTGGTTCATGCGCACAAGC CCCATCCCACAGCCCTCCCAACAAACCCAAGCTAGTGGTGAAGCCTCCAGGCAGCAGCCTCAATGGGGTTCACCCCAACCCCACTCCCAT TGTCCAGCGGCTGCCGGCCTTTCTAGACAATCACAATTATGCCAAGTCCCCCATGCAGGAGGAAGAAGACCTGGCGGCAGGTGTGGGCCG CAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTACTCAGATGATGAGGATGACTATGAGGATGACGAGGAGGATGACGTGCAGAACACCAA CTCTGCCCTTAGGTATAAGGGGAAGGGAACAGGGAAGCCAGGGGCATTGAGCGGTTCTGCTGATGGGCAACTGTCAGTGCTGCAGCCCAA CACCATCAACGTCTTGGCTGAGAAGCTCAAAGAGTCCCAGAAGGACCTCTCAATTCCTCTGTCCATCAAGACTAGCAGCGGGGCTGGGAG TCCGGCTGTGGCAGTGCCCACACACTCGCAGCCCTCACCCACCCCCAGCAATGAGAGTACAGACACGGCCTCTGAGATCGGCAGTGCTTT CAACTCGCCACTGCGCTCGCCTATCCGCTCAGCCAACCCGACGCGGCCCTCCAGCCCTGTCACCTCCCACATCTCCAAGGTGCTTTTTGG AGAGGATGACAGCCTGCTGCGTGTTGACTGCATACGCTACAACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGCCTGCTGCA CCTGGCTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACAGAGGGTGGGAAGGGTTCCTCGCCCTCCATCAGACCAATCCAAGGCAGCCA GGGGTCCAGCAGCCCAGTGGAGAAGGAGGTCGTGGAAGCCACGGACAGCAGAGAGAAGACGGGGATGGTGAGGCCTGGCGAGCCCTTGAG TGGGGAGAAATACTCACCCAAGGGGGAGAACCTGGACCTTGCAATGTCCAAGGAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGT GGTGAAGACGCTGACGCGGCACCACCTGTACTGCGAGCCCCCCGTGGAGCAGCCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGA CTCTTTGCCTGAGTTCACGGTGCAGATGGGGAACTTGCGCTTCTCCCTGGGTCACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCC TGTGGCAGCCCAGGTGGGCTTGGGGGTGGGCACCTCTCTTCTGGCTCTGGGTGTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAA GCAGGCCCTGAGGGACTATAAGAAGGTTCAGATCCAGCTGGAGAATCTGGAGAGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGA CCTCATGACTGAGATGACCGATCTCACCAGTGACCTCCTGGGCAGCGGCATCCCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTT CTTCCCTGGGCACCGCGAGTCGCCCTTGCACCGGGACCTGGGTGTGCCTGAGAGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCT CTCTAACCTGCTCAACAGCAAGCTCTTCCTCACCAAGTTCATCCACACGCTGGAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTA CGTGGCATCTCTGCTCACCGTGGCACTGCATGGGAAGCTTGAGTATTTCACTGACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCA GTATGTGGCCAAGAACCCCAAGCTGATGCTGCGCAGGACAGAGACTGTGGTGGAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTA TACCTTCGTGAGGGACTCCGTAGGGGAGCCTCTGTACATGCTCTTTCGAGGGATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGT GACAGGCAAGGCCAAATACACCTTGAACGACAACCGCCTGCTCAGAGAGGATGTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGC TGTGGGGCCTGGGGCAGGAGAGGCCCAGGGCGTGCCCGTGAAGGTCCTAGACTGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGA CCAGCTTTATAAAGGAGTGCCTCTCACCCAGCGGCCAGACCCTCGCACCCTTGATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCAT TCTTTCTGACGAGGATGTCACTTCTGAGGTCCAGGGTCTGTGGAGGCGCCTGAACACACTGCAGCATTACAAGGTCCCAGATGGAGCAAC TGTGGCCCTCGTCCCCTGCCTCACCAAGCATGTGCTCCGGGAAAACCAGGATTATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGT AGATGAGGGGGGCATCCGGCCCTGGCACCTGGTGAAGCCAAGTGATGAGCCGGAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGG GGAGCGTGAGCGCGCCAAGGCCATCCCTGAGATCTACCTGACCCGCCTGCTGTCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCT GTTCCAGGTGATTCTCAGCACCAGCCGCCCCGTGCCGCTCGCTGTGAAGTACTTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGG CATCTCCGACCAGGACACCATCCACATCTGGAAGACCAACAGCTTGCCTCTGAGGTTCTGGATCAATATAATAAAAAACCCGCAGTTTGT GTTCGACGTGCAAACATCTGATAACATGGATGCGGTGCTCCTTGTCATTGCACAGACCTTCATGGACGCCTGCACCCTGGCCGACCACAA GCTGGGCCGGGACTCCCCGATCAACAAACTTCTGTATGCACGGGACATTCCCCGGTACAAGCGGATGGTGGAAAGGTACTATGCAGACAT CAGACAGACTGTCCCAGCCAGCGACCAAGAGATGAACTCTGTCCTGGCTGAACTGTCCTGGAACTACTCCGGAGACCTCGGGGCGCGAGT GGCCCTGCATGAACTCTACAAGTACATCAACAAGTACTATGACCAGATCATCACTGCCCTGGAGGAGGATGGCACGGCCCAGAAGATGCA GCTGGGCTATCGGCTCCAGCAGATTGCAGCTGCTGTGGAAAACAAGGTCACAGATCTATAGGAACCCAGGAGCCACGGCCTGCTGTTGCT TCAGCCTGGCCTGGGCAGCCCTGGAAGCTCGGAGGAGAGGCCACCTTCTTAGGTGCCTGTAGTGACTGACAAGCAGAGTTAGTGGAAGGT GACTCCCAGTCTCCTGGTGGCTCTGGCCTCGGCCCTGCTGGATCCACCTCCTAGACCCGGGGCCTCAAGGCTCATGGGGTAGTACCCAGC CTGCTCCCCGAGTCCAGCGACCCTGTGACACCGGTCTGCAGGGAGTTGGGGACTAAGGGCTTCCAGAGAGTGGCTGGAAGAGACTCCAGG CCCCTGGGGAGACTGTACTGTTCCTGAACACTGGCCTTGGCCACACTGGGATTCGGAGAGGAAGGAGGAGAGCCCCATGCTTCCTGTCTG CCTCCTCCACCATCCCTGACCTCAGTTGAGCTGCCTCTGGCCTTGTTGCTGCTGCCACATCCTAGGTCTAAGAGTTGAACGCCTCTCCTA GGCCACTACAAACTGACCCCTCAGCAGGGCTGGCTGCCACAGGGCTGCCCTGCCTCATAGGTAGCCATGGTGAGGGCTATCTGCTGCAGG >8973_8973_8_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000460680_PLXNB1_chr3_48455480_ENST00000358536_length(amino acids)=1362AA_BP=630 MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNS CATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRL FELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEALQQLIRVTQPEL IQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAF LDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAE KLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLR VDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPK GENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGL GVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRES PLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPK LMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGE AQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCL TKHVLRENQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST SRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPI NKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQ -------------------------------------------------------------- >8973_8973_9_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000460680_PLXNB1_chr3_48455480_ENST00000448774_length(transcript)=4602nt_BP=2362nt CGCTCCGCCCCTCCCCTCGCAGCACCCGGGCCTAGTACTGCCCGTCCCGCCCCTCCTCTCGAGCCTCAGCGCTCAGCATCGCCCGGACCC CCTCTTCCCTTCGCCCGCCTCGTCCCGACCCTCCCCTTCGCCCCCGTCCCGCCCCGCCCCTCCCCTTCGCCCCCGTCCCGTCCCGCCCCG CCCCTCCCCTTCGCCCCCGTCCCTCCCCTTCGCCCCCGTCCCTCCGCGCGTGCGCGTTCGCCTTCGAGCGCATGCCCGCATCTGCTGTCC GACAGGCGGAAGACGAGCCCAGAGGCGGAGCAGGGCCGTCGCGCCTTGGTGACGTCTGCCGCCGGCGCGGGCGGGTGACGCGACTGGGCC CGTTGTCTGTGTGTGGGACTGAGGGGCCCCGGGGGCGGTGGGGGCTCCCGGTGGGGGCAGCGGTGGGGAGGGAGGGCCTGGACATGGCGC TGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTCGTGGAAGATTTCGG TGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTCCTGTTCAAATGGAT CGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAATAACATGTTCTTTGC CCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTGGGACCCACCCTGAG TCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCCAAGGCCCATAATAG CCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTCCACTTTGTCAGCTA TGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAGGACGAGGAGTGGAC AGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGGAGCCCTACCACGACATCCGCTTCAACCTGATGGCAGT GGTGCCCGACCGCAGGATCAAGTATGAGGCCAGGCTGCATGTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGCTGAT AAGAGTAACACAGCCAGAGCTGATTCAGACCCACAAGTCTCAAGAGTCACAGCTGCCTGAGGAGTCCAAGTCAGCCAGCAACAAGTCCCC GCTGGTGCTGGAAGCAAACAGGGCCCCTGCAGCCTCTGAGGGCAACCACACAGATGGTGCAGAGGAGGCGGCTGGTTCATGCGCACAAGC CCCATCCCACAGCCCTCCCAACAAACCCAAGCTAGTGGTGAAGCCTCCAGGCAGCAGCCTCAATGGGGTTCACCCCAACCCCACTCCCAT TGTCCAGCGGCTGCCGGCCTTTCTAGACAATCACAATTATGCCAAGTCCCCCATGCAGGAGGAAGAAGACCTGGCGGCAGGTGTGGGCCG CAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTACTCAGATGATGAGGATGACTATGAGGATGACGAGGAGGATGACGTGCAGAACACCAA CTCTGCCCTTAGGTATAAGGGGAAGGGAACAGGGAAGCCAGGGGCATTGAGCGGTTCTGCTGATGGGCAACTGTCAGTGCTGCAGCCCAA CACCATCAACGTCTTGGCTGAGAAGCTCAAAGAGTCCCAGAAGGACCTCTCAATTCCTCTGTCCATCAAGACTAGCAGCGGGGCTGGGAG TCCGGCTGTGGCAGTGCCCACACACTCGCAGCCCTCACCCACCCCCAGCAATGAGAGTACAGACACGGCCTCTGAGATCGGCAGTGCTTT CAACTCGCCACTGCGCTCGCCTATCCGCTCAGCCAACCCGACGCGGCCCTCCAGCCCTGTCACCTCCCACATCTCCAAGGTGCTTTTTGG AGAGGATGACAGCCTGCTGCGTGTTGACTGCATACGCTACAACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGCCTGCTGCA CCTGGCTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACAGAGGGTGGGAAGGGTTCCTCGCCCTCCATCAGACCAATCCAAGGCAGCCA GGGGTCCAGCAGCCCAGTGGAGAAGGAGGTCGTGGAAGCCACGGACAGCAGAGAGAAGACGGGGATGGTGAGGCCTGGCGAGCCCTTGAG TGGGGAGAAATACTCACCCAAGGGGGAGAACCTGGACCTTGCAATGTCCAAGGAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGT GGTGAAGACGCTGACGCGGCACCACCTGTACTGCGAGCCCCCCGTGGAGCAGCCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGA CTCTTTGCCTGAGTTCACGGTGCAGATGGGGAACTTGCGCTTCTCCCTGGGTCACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCC TGTGGCAGCCCAGGTGGGCTTGGGGGTGGGCACCTCTCTTCTGGCTCTGGGTGTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAA GCAGGCCCTGAGGGACTATAAGAAGGTTCAGATCCAGCTGGAGAATCTGGAGAGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGA CCTCATGACTGAGATGACCGATCTCACCAGTGACCTCCTGGGCAGCGGCATCCCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTT CTTCCCTGGGCACCGCGAGTCGCCCTTGCACCGGGACCTGGGTGTGCCTGAGAGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCT CTCTAACCTGCTCAACAGCAAGCTCTTCCTCACCAAGTTCATCCACACGCTGGAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTA CGTGGCATCTCTGCTCACCGTGGCACTGCATGGGAAGCTTGAGTATTTCACTGACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCA GTATGTGGCCAAGAACCCCAAGCTGATGCTGCGCAGGACAGAGACTGTGGTGGAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTA TACCTTCGTGAGGGACTCCGTAGGGGAGCCTCTGTACATGCTCTTTCGAGGGATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGT GACAGGCAAGGCCAAATACACCTTGAACGACAACCGCCTGCTCAGAGAGGATGTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGC TGTGGGGCCTGGGGCAGGAGAGGCCCAGGGCGTGCCCGTGAAGGTCCTAGACTGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGA CCAGCTTTATAAAGGAGTGCCTCTCACCCAGCGGCCAGACCCTCGCACCCTTGATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCAT TCTTTCTGACGAGGATGTCACTTCTGAGGTCCAGGGTCTGTGGAGGCGCCTGAACACACTGCAGCATTACAAGGTCCCAGATGGAGCAAC TGTGGCCCTCGTCCCCTGCCTCACCAAGCATGTGCTCCGGGAAAACCAGGATTATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGT AGATGAGGGGGGCATCCGGCCCTGGCACCTGGTGAAGCCAAGTGATGAGCCGGAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGG GGAGCGTGAGCGCGCCAAGGCCATCCCTGAGATCTACCTGACCCGCCTGCTGTCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCT GTTCCAGGTGATTCTCAGCACCAGCCGCCCCGTGCCGCTCGCTGTGAAGTACTTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGG CATCTCCGACCAGGACACCATCCACATCTGGAAGACCAACAGCTTGCCTCTGAGGTTCTGGATCAATATAATAAAAAACCCGCAGTTTGT GTTCGACGTGCAAACATCTGATAACATGGATGCGGTGCTCCTTGTCATTGCACAGACCTTCATGGACGCCTGCACCCTGGCCGACCACAA GCTGGGCCGGGACTCCCCGATCAACAAACTTCTGTATGCACGGGACATTCCCCGGTACAAGCGGATGGTGGAAAGGTACTATGCAGACAT CAGACAGACTGTCCCAGCCAGCGACCAAGAGATGAACTCTGTCCTGGCTGAACTGTCCTGGAACTACTCCGGAGACCTCGGGGCGCGAGT GGCCCTGCATGAACTCTACAAGTACATCAACAAGTACTATGACCAGATCATCACTGCCCTGGAGGAGGATGGCACGGCCCAGAAGATGCA GCTGGGCTATCGGCTCCAGCAGATTGCAGCTGCTGTGGAAAACAAGGTCACAGATCTATAGGAACCCAGGAGCCACGGCCTGCTGTTGCT >8973_8973_9_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000460680_PLXNB1_chr3_48455480_ENST00000448774_length(amino acids)=1362AA_BP=630 MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNS CATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRL FELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEALQQLIRVTQPEL IQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAF LDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAE KLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLR VDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPK GENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGL GVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRES PLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPK LMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGE AQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCL TKHVLRENQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST SRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPI NKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQ -------------------------------------------------------------- >8973_8973_10_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000460680_PLXNB1_chr3_48455480_ENST00000456774_length(transcript)=4561nt_BP=2362nt CGCTCCGCCCCTCCCCTCGCAGCACCCGGGCCTAGTACTGCCCGTCCCGCCCCTCCTCTCGAGCCTCAGCGCTCAGCATCGCCCGGACCC CCTCTTCCCTTCGCCCGCCTCGTCCCGACCCTCCCCTTCGCCCCCGTCCCGCCCCGCCCCTCCCCTTCGCCCCCGTCCCGTCCCGCCCCG CCCCTCCCCTTCGCCCCCGTCCCTCCCCTTCGCCCCCGTCCCTCCGCGCGTGCGCGTTCGCCTTCGAGCGCATGCCCGCATCTGCTGTCC GACAGGCGGAAGACGAGCCCAGAGGCGGAGCAGGGCCGTCGCGCCTTGGTGACGTCTGCCGCCGGCGCGGGCGGGTGACGCGACTGGGCC CGTTGTCTGTGTGTGGGACTGAGGGGCCCCGGGGGCGGTGGGGGCTCCCGGTGGGGGCAGCGGTGGGGAGGGAGGGCCTGGACATGGCGC TGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTCGTGGAAGATTTCGG TGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTCCTGTTCAAATGGAT CGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAATAACATGTTCTTTGC CCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTGGGACCCACCCTGAG TCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCCAAGGCCCATAATAG CCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTCCACTTTGTCAGCTA TGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAGGACGAGGAGTGGAC AGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGGAGCCCTACCACGACATCCGCTTCAACCTGATGGCAGT GGTGCCCGACCGCAGGATCAAGTATGAGGCCAGGCTGCATGTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGCTGAT AAGAGTAACACAGCCAGAGCTGATTCAGACCCACAAGTCTCAAGAGTCACAGCTGCCTGAGGAGTCCAAGTCAGCCAGCAACAAGTCCCC GCTGGTGCTGGAAGCAAACAGGGCCCCTGCAGCCTCTGAGGGCAACCACACAGATGGTGCAGAGGAGGCGGCTGGTTCATGCGCACAAGC CCCATCCCACAGCCCTCCCAACAAACCCAAGCTAGTGGTGAAGCCTCCAGGCAGCAGCCTCAATGGGGTTCACCCCAACCCCACTCCCAT TGTCCAGCGGCTGCCGGCCTTTCTAGACAATCACAATTATGCCAAGTCCCCCATGCAGGAGGAAGAAGACCTGGCGGCAGGTGTGGGCCG CAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTACTCAGATGATGAGGATGACTATGAGGATGACGAGGAGGATGACGTGCAGAACACCAA CTCTGCCCTTAGGTATAAGGGGAAGGGAACAGGGAAGCCAGGGGCATTGAGCGGTTCTGCTGATGGGCAACTGTCAGTGCTGCAGCCCAA CACCATCAACGTCTTGGCTGAGAAGCTCAAAGAGTCCCAGAAGGACCTCTCAATTCCTCTGTCCATCAAGACTAGCAGCGGGGCTGGGAG TCCGGCTGTGGCAGTGCCCACACACTCGCAGCCCTCACCCACCCCCAGCAATGAGAGTACAGACACGGCCTCTGAGATCGGCAGTGCTTT CAACTCGCCACTGCGCTCGCCTATCCGCTCAGCCAACCCGACGCGGCCCTCCAGCCCTGTCACCTCCCACATCTCCAAGGTGCTTTTTGG AGAGGATGACAGCCTGCTGCGTGTTGACTGCATACGCTACAACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGCCTGCTGCA CCTGGCTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACAGAGGGTGGGAAGGGTTCCTCGCCCTCCATCAGACCAATCCAAGGCAGCCA GGGGTCCAGCAGCCCAGTGGAGAAGGAGGTCGTGGAAGCCACGGACAGCAGAGAGAAGACGGGGATGGTGAGGCCTGGCGAGCCCTTGAG TGGGGAGAAATACTCACCCAAGGGGGAGAACCTGGACCTTGCAATGTCCAAGGAGGAGGTGGTGGCTATGATAGGGGATGGCCCCTGTGT GGTGAAGACGCTGACGCGGCACCACCTGTACTGCGAGCCCCCCGTGGAGCAGCCCCTGCCACGGCACCATGCCCTCCGAGAGGCACCTGA CTCTTTGCCTGAGTTCACGGTGCAGATGGGGAACTTGCGCTTCTCCCTGGGTCACGTGCAGTATGACGGCGAGAGCCCTGGGGCTTTTCC TGTGGCAGCCCAGGTGGGCTTGGGGGTGGGCACCTCTCTTCTGGCTCTGGGTGTCATCATCATTGTCCTCATGTACAGGAGGAAGAGCAA GCAGGCCCTGAGGGACTATAAGAAGGTTCAGATCCAGCTGGAGAATCTGGAGAGCAGTGTGCGGGACCGCTGCAAGAAGGAATTCACAGA CCTCATGACTGAGATGACCGATCTCACCAGTGACCTCCTGGGCAGCGGCATCCCCTTCCTCGACTACAAGGTGTATGCGGAGAGGATCTT CTTCCCTGGGCACCGCGAGTCGCCCTTGCACCGGGACCTGGGTGTGCCTGAGAGCAGACGGCCCACTGTGGAGCAAGGGCTGGGGCAGCT CTCTAACCTGCTCAACAGCAAGCTCTTCCTCACCAAGTTCATCCACACGCTGGAGAGCCAGCGCACCTTTTCAGCTCGGGACCGTGCCTA CGTGGCATCTCTGCTCACCGTGGCACTGCATGGGAAGCTTGAGTATTTCACTGACATCCTCCGCACTCTGCTCAGTGACCTGGTTGCCCA GTATGTGGCCAAGAACCCCAAGCTGATGCTGCGCAGGACAGAGACTGTGGTGGAGAAGCTGCTCACCAACTGGATGTCCATCTGTCTGTA TACCTTCGTGAGGGACTCCGTAGGGGAGCCTCTGTACATGCTCTTTCGAGGGATTAAGCACCAAGTGGATAAGGGGCCAGTGGACAGTGT GACAGGCAAGGCCAAATACACCTTGAACGACAACCGCCTGCTCAGAGAGGATGTGGAGTACCGTCCCCTGACCTTGAATGCACTATTGGC TGTGGGGCCTGGGGCAGGAGAGGCCCAGGGCGTGCCCGTGAAGGTCCTAGACTGTGACACCATCTCCCAGGCAAAGGAGAAGATGCTGGA CCAGCTTTATAAAGGAGTGCCTCTCACCCAGCGGCCAGACCCTCGCACCCTTGATGTTGAGTGGCGGTCTGGGGTGGCCGGGCACCTCAT TCTTTCTGACGAGGATGTCACTTCTGAGGTCCAGGGTCTGTGGAGGCGCCTGAACACACTGCAGCATTACAAGGTCCCAGATGGAGCAAC TGTGGCCCTCGTCCCCTGCCTCACCAAGCATGTGCTCCGGGAAAACCAGGATTATGTCCCTGGAGAGCGGACCCCAATGCTGGAGGATGT AGATGAGGGGGGCATCCGGCCCTGGCACCTGGTGAAGCCAAGTGATGAGCCGGAGCCGCCCAGGCCTCGGAGGGGCAGCCTTCGGGGCGG GGAGCGTGAGCGCGCCAAGGCCATCCCTGAGATCTACCTGACCCGCCTGCTGTCCATGAAGGGCACCCTGCAGAAGTTCGTGGATGACCT GTTCCAGGTGATTCTCAGCACCAGCCGCCCCGTGCCGCTCGCTGTGAAGTACTTCTTTGACCTGCTGGATGAGCAGGCCCAGCAGCATGG CATCTCCGACCAGGACACCATCCACATCTGGAAGACCAACAGCTTGCCTCTGAGGTTCTGGATCAATATAATAAAAAACCCGCAGTTTGT GTTCGACGTGCAAACATCTGATAACATGGATGCGGTGCTCCTTGTCATTGCACAGACCTTCATGGACGCCTGCACCCTGGCCGACCACAA GCTGGGCCGGGACTCCCCGATCAACAAACTTCTGTATGCACGGGACATTCCCCGGTACAAGCGGATGGTGGAAAGGTACTATGCAGACAT CAGACAGACTGTCCCAGCCAGCGACCAAGAGATGAACTCTGTCCTGGCTGAACTGTCCTGGAACTACTCCGGAGACCTCGGGGCGCGAGT GGCCCTGCATGAACTCTACAAGTACATCAACAAGTACTATGACCAGATCATCACTGCCCTGGAGGAGGATGGCACGGCCCAGAAGATGCA >8973_8973_10_BAP1-PLXNB1_BAP1_chr3_52437154_ENST00000460680_PLXNB1_chr3_48455480_ENST00000456774_length(amino acids)=1363AA_BP=630 MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNS CATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRL FELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEALQQLIRVTQPEL IQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAF LDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAE KLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLR VDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPK GENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGL GVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRES PLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPK LMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGE AQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCL TKHVLRENQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST SRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPI NKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for BAP1-PLXNB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | BAP1 | chr3:52437154 | chr3:48455480 | ENST00000460680 | - | 14 | 17 | 596_721 | 630.0 | 730.0 | BRCA1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for BAP1-PLXNB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for BAP1-PLXNB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BAP1 | C3280492 | TUMOR PREDISPOSITION SYNDROME | 7 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Hgene | BAP1 | C0220633 | Uveal melanoma | 5 | CGI;CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Hgene | BAP1 | C0345967 | Malignant mesothelioma | 5 | CTD_human |
| Hgene | BAP1 | C0007134 | Renal Cell Carcinoma | 4 | CTD_human |
| Hgene | BAP1 | C0025500 | Mesothelioma | 4 | CGI;CTD_human |
| Hgene | BAP1 | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 4 | CGI;CTD_human |
| Hgene | BAP1 | C1266042 | Chromophobe Renal Cell Carcinoma | 4 | CTD_human |
| Hgene | BAP1 | C1266043 | Sarcomatoid Renal Cell Carcinoma | 4 | CTD_human |
| Hgene | BAP1 | C1266044 | Collecting Duct Carcinoma of the Kidney | 4 | CTD_human |
| Hgene | BAP1 | C1306837 | Papillary Renal Cell Carcinoma | 4 | CTD_human |
| Hgene | BAP1 | C0006142 | Malignant neoplasm of breast | 2 | CGI;CTD_human |
| Hgene | BAP1 | C0024623 | Malignant neoplasm of stomach | 2 | CTD_human |
| Hgene | BAP1 | C0038356 | Stomach Neoplasms | 2 | CTD_human |
| Hgene | BAP1 | C0151779 | Cutaneous Melanoma | 2 | CGI;CTD_human;GENOMICS_ENGLAND |
| Hgene | BAP1 | C0206698 | Cholangiocarcinoma | 2 | CTD_human |
| Hgene | BAP1 | C0345905 | Intrahepatic Cholangiocarcinoma | 2 | CTD_human |
| Hgene | BAP1 | C0346373 | Malignant melanoma of iris | 2 | ORPHANET |
| Hgene | BAP1 | C0346388 | Malignant melanoma of choroid | 2 | ORPHANET |
| Hgene | BAP1 | C0678222 | Breast Carcinoma | 2 | CGI;CTD_human |
| Hgene | BAP1 | C1257931 | Mammary Neoplasms, Human | 2 | CTD_human |
| Hgene | BAP1 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
| Hgene | BAP1 | C1708349 | Hereditary Diffuse Gastric Cancer | 2 | CTD_human |
| Hgene | BAP1 | C3805278 | Extrahepatic Cholangiocarcinoma | 2 | CTD_human |
| Hgene | BAP1 | C4704874 | Mammary Carcinoma, Human | 2 | CTD_human |
| Hgene | BAP1 | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
| Hgene | BAP1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | BAP1 | C0005967 | Bone neoplasms | 1 | CTD_human |
| Hgene | BAP1 | C0007102 | Malignant tumor of colon | 1 | CTD_human |
| Hgene | BAP1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | BAP1 | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
| Hgene | BAP1 | C0018675 | Head Neoplasms | 1 | CTD_human |
| Hgene | BAP1 | C0022665 | Kidney Neoplasm | 1 | CGI;CTD_human |
| Hgene | BAP1 | C0023418 | leukemia | 1 | CTD_human |
| Hgene | BAP1 | C0023798 | Lipoma | 1 | CTD_human |
| Hgene | BAP1 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | BAP1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | BAP1 | C0025286 | Meningioma | 1 | CTD_human;GENOMICS_ENGLAND |
| Hgene | BAP1 | C0027533 | Neck Neoplasms | 1 | CTD_human |
| Hgene | BAP1 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| Hgene | BAP1 | C0030421 | Paraganglioma | 1 | CTD_human |
| Hgene | BAP1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | BAP1 | C0039590 | Testicular Neoplasms | 1 | CTD_human |
| Hgene | BAP1 | C0040100 | Thymoma | 1 | CTD_human |
| Hgene | BAP1 | C0042138 | Uterine Neoplasms | 1 | CTD_human |
| Hgene | BAP1 | C0085136 | Central Nervous System Neoplasms | 1 | CTD_human |
| Hgene | BAP1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Hgene | BAP1 | C0153567 | Uterine Cancer | 1 | CTD_human |
| Hgene | BAP1 | C0153594 | Malignant neoplasm of testis | 1 | CTD_human |
| Hgene | BAP1 | C0205822 | Hibernoma | 1 | CTD_human |
| Hgene | BAP1 | C0205823 | Pleomorphic Lipoma | 1 | CTD_human |
| Hgene | BAP1 | C0205834 | Meningiomas, Multiple | 1 | CTD_human |
| Hgene | BAP1 | C0205969 | Thymic Carcinoma | 1 | CTD_human |
| Hgene | BAP1 | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
| Hgene | BAP1 | C0206694 | Mucoepidermoid Carcinoma | 1 | CTD_human |
| Hgene | BAP1 | C0206739 | Epithelioid and spindle cell nevus | 1 | CTD_human |
| Hgene | BAP1 | C0206754 | Neuroendocrine Tumors | 1 | CTD_human |
| Hgene | BAP1 | C0206769 | Nevi and Melanomas | 1 | CTD_human |
| Hgene | BAP1 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human;UNIPROT |
| Hgene | BAP1 | C0259785 | Malignant Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0278996 | Malignant Head and Neck Neoplasm | 1 | CTD_human |
| Hgene | BAP1 | C0279530 | Malignant Bone Neoplasm | 1 | CTD_human |
| Hgene | BAP1 | C0281784 | Benign Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0334605 | Meningothelial meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0334606 | Fibrous Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0334607 | Psammomatous Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0334608 | Angiomatous Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0334609 | Hemangioblastic Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0334610 | Hemangiopericytic Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0334611 | Transitional Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0345904 | Malignant neoplasm of liver | 1 | CTD_human |
| Hgene | BAP1 | C0346647 | Malignant neoplasm of pancreas | 1 | CTD_human |
| Hgene | BAP1 | C0347515 | Spinal Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0349604 | Intracranial Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| Hgene | BAP1 | C0431121 | Clear Cell Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0457190 | Xanthomatous Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0740457 | Malignant neoplasm of kidney | 1 | CGI;CTD_human |
| Hgene | BAP1 | C0746787 | Cancer of Neck | 1 | CTD_human |
| Hgene | BAP1 | C0751177 | Cancer of Head | 1 | CTD_human |
| Hgene | BAP1 | C0751303 | Cerebral Convexity Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0751304 | Parasagittal Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C0751620 | Central Nervous System Neoplasms, Primary | 1 | CTD_human |
| Hgene | BAP1 | C0887900 | Upper Aerodigestive Tract Neoplasms | 1 | CTD_human |
| Hgene | BAP1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Hgene | BAP1 | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human |
| Hgene | BAP1 | C1334261 | Intraorbital Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C1334271 | Intraventricular Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C1335107 | Olfactory Groove Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C1368275 | Pigmented Basal Cell Carcinoma | 1 | CTD_human |
| Hgene | BAP1 | C1384406 | Secretory meningioma | 1 | CTD_human |
| Hgene | BAP1 | C1384408 | Microcystic meningioma | 1 | CTD_human |
| Hgene | BAP1 | C1527197 | Angioblastic Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C1565950 | Posterior Fossa Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C1565951 | Sphenoid Wing Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C1708353 | Hereditary Paraganglioma-Pheochromocytoma Syndrome | 1 | CLINGEN |
| Hgene | BAP1 | C1720811 | Tumor of Rete Testis | 1 | CTD_human |
| Hgene | BAP1 | C2314896 | Familial Atypical Mole Melanoma Syndrome | 1 | ORPHANET |
| Hgene | BAP1 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |
| Hgene | BAP1 | C3163622 | Papillary Meningioma | 1 | CTD_human |
| Hgene | BAP1 | C3489413 | Lipomatosis, Multiple | 1 | CTD_human |
| Hgene | BAP1 | C4721806 | Carcinoma, Basal Cell | 1 | CTD_human |
| Tgene | C1535926 | Neurodevelopmental Disorders | 1 | CTD_human |
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