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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CAPZB-TMCO4 (FusionGDB2 ID:HG832TG255104)

Fusion Gene Summary for CAPZB-TMCO4

Fusion gene summary

Fusion gene information	Fusion gene name: CAPZB-TMCO4
	Fusion gene ID: hg832tg255104
		Hgene	Tgene
	Gene symbol	CAPZB	TMCO4
	Gene ID	832	255104
	Gene name	capping actin protein of muscle Z-line subunit beta	transmembrane and coiled-coil domains 4
	Synonyms	CAPB\|CAPPB\|CAPZ	-
	Cytomap	('CAPZB')('TMCO4') 1p36.13	1p36.13
	Type of gene	protein-coding	protein-coding
	Description	F-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, betaepididymis secretory sperm binding protein	transmembrane and coiled-coil domain-containing protein 4
	Modification date	20200320	20200313
	UniProtAcc	P47756	.
	Ensembl transtripts involved in fusion gene	ENST00000264202, ENST00000264203, ENST00000375142, ENST00000375144, ENST00000401084, ENST00000433834, ENST00000482808,
Fusion gene scores	* DoF score	20 X 22 X 11=4840	8 X 10 X 7=560
	# samples	29	13
	** MAII score	log2(29/4840*10)=-4.06088224214702 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/560*10)=-2.10691520391651 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CAPZB [Title/Abstract] AND TMCO4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CAPZB(19811930)-TMCO4(20027378), # samples:5
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CAPZB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TMCO4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-1506-01A	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
ChimerDB4	OV	TCGA-36-1581-01A	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
ChimerDB4	STAD	TCGA-VQ-A922-01A	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
ChimerDB4	UCEC	TCGA-KP-A3VZ-01A	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
ChimerDB4	UCS	TCGA-N7-A4Y8-01A	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
ChimerDB4	UCS	TCGA-N7-A4Y8	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
ChimerDB4	UCS	TCGA-N7-A4Y8	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-

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Fusion Gene ORF analysis for CAPZB-TMCO4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000264202	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5CDS-5UTR	ENST00000264202	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000264202	ENST00000375122	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000264202	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
5CDS-5UTR	ENST00000264202	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5CDS-5UTR	ENST00000264202	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000264202	ENST00000489814	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000264202	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
5CDS-5UTR	ENST00000264203	ENST00000375122	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000264203	ENST00000489814	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000375142	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5CDS-5UTR	ENST00000375142	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000375142	ENST00000375122	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000375142	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
5CDS-5UTR	ENST00000375142	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5CDS-5UTR	ENST00000375142	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000375142	ENST00000489814	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000375142	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
5CDS-5UTR	ENST00000375144	ENST00000375122	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000375144	ENST00000489814	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000401084	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5CDS-5UTR	ENST00000401084	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000401084	ENST00000375122	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000401084	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
5CDS-5UTR	ENST00000401084	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5CDS-5UTR	ENST00000401084	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000401084	ENST00000489814	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000401084	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
5CDS-5UTR	ENST00000433834	ENST00000375122	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000433834	ENST00000375122	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000433834	ENST00000489814	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5CDS-5UTR	ENST00000433834	ENST00000489814	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
5UTR-3CDS	ENST00000264203	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5UTR-3CDS	ENST00000264203	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5UTR-3CDS	ENST00000264203	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
5UTR-3CDS	ENST00000264203	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5UTR-3CDS	ENST00000264203	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5UTR-3CDS	ENST00000264203	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
5UTR-3CDS	ENST00000482808	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5UTR-3CDS	ENST00000482808	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5UTR-3CDS	ENST00000482808	ENST00000294543	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5UTR-3CDS	ENST00000482808	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
5UTR-3CDS	ENST00000482808	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5UTR-3CDS	ENST00000482808	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5UTR-3CDS	ENST00000482808	ENST00000375127	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5UTR-3CDS	ENST00000482808	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
5UTR-5UTR	ENST00000264203	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5UTR-5UTR	ENST00000264203	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5UTR-5UTR	ENST00000264203	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
5UTR-5UTR	ENST00000264203	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5UTR-5UTR	ENST00000264203	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5UTR-5UTR	ENST00000264203	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
5UTR-5UTR	ENST00000482808	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5UTR-5UTR	ENST00000482808	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5UTR-5UTR	ENST00000482808	ENST00000375122	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5UTR-5UTR	ENST00000482808	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
5UTR-5UTR	ENST00000482808	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
5UTR-5UTR	ENST00000482808	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
5UTR-5UTR	ENST00000482808	ENST00000489814	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
5UTR-5UTR	ENST00000482808	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
Frame-shift	ENST00000264202	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
Frame-shift	ENST00000264202	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000264202	ENST00000294543	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000264202	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
Frame-shift	ENST00000264202	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000264202	ENST00000375127	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000264202	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
Frame-shift	ENST00000264203	ENST00000294543	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000264203	ENST00000375127	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000375142	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
Frame-shift	ENST00000375142	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000375142	ENST00000294543	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000375142	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
Frame-shift	ENST00000375142	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000375142	ENST00000375127	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000375142	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
Frame-shift	ENST00000375144	ENST00000294543	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000375144	ENST00000375127	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000401084	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
Frame-shift	ENST00000401084	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000401084	ENST00000294543	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000401084	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
Frame-shift	ENST00000401084	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000401084	ENST00000375127	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000401084	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
Frame-shift	ENST00000433834	ENST00000294543	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000433834	ENST00000294543	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000433834	ENST00000375127	CAPZB	chr1	19711999	-	TMCO4	chr1	20027378	-
Frame-shift	ENST00000433834	ENST00000375127	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
In-frame	ENST00000264202	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
In-frame	ENST00000375142	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
In-frame	ENST00000401084	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
intron-3CDS	ENST00000264202	ENST00000294543	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000264202	ENST00000375127	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000264203	ENST00000294543	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000264203	ENST00000375127	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000375142	ENST00000294543	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000375142	ENST00000375127	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000375144	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
intron-3CDS	ENST00000375144	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000375144	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
intron-3CDS	ENST00000375144	ENST00000294543	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000375144	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
intron-3CDS	ENST00000375144	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000375144	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
intron-3CDS	ENST00000375144	ENST00000375127	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000401084	ENST00000294543	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000401084	ENST00000375127	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000433834	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
intron-3CDS	ENST00000433834	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000433834	ENST00000294543	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
intron-3CDS	ENST00000433834	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
intron-3CDS	ENST00000433834	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000433834	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
intron-3CDS	ENST00000482808	ENST00000294543	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-3CDS	ENST00000482808	ENST00000375127	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000264202	ENST00000375122	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000264202	ENST00000489814	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000264203	ENST00000375122	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000264203	ENST00000489814	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000375142	ENST00000375122	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000375142	ENST00000489814	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000375144	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
intron-5UTR	ENST00000375144	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000375144	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
intron-5UTR	ENST00000375144	ENST00000375122	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000375144	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
intron-5UTR	ENST00000375144	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000375144	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
intron-5UTR	ENST00000375144	ENST00000489814	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000401084	ENST00000375122	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000401084	ENST00000489814	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000433834	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
intron-5UTR	ENST00000433834	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000433834	ENST00000375122	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
intron-5UTR	ENST00000433834	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-
intron-5UTR	ENST00000433834	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000433834	ENST00000489814	CAPZB	chr1	19811930	-	TMCO4	chr1	20021044	-
intron-5UTR	ENST00000482808	ENST00000375122	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-
intron-5UTR	ENST00000482808	ENST00000489814	CAPZB	chr1	19810684	-	TMCO4	chr1	20027378	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000401084	CAPZB	chr1	19811930	-	ENST00000375127	TMCO4	chr1	20009937	-	769	137	566	138	142
ENST00000375142	CAPZB	chr1	19811930	-	ENST00000375127	TMCO4	chr1	20009937	-	682	50	479	51	142
ENST00000264202	CAPZB	chr1	19811930	-	ENST00000375127	TMCO4	chr1	20009937	-	684	52	481	53	142

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000401084	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-	0.079941094	0.92005897
ENST00000375142	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-	0.05178243	0.9482176
ENST00000264202	ENST00000375127	CAPZB	chr1	19811930	-	TMCO4	chr1	20009937	-	0.057433374	0.9425666

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Fusion Genomic Features for CAPZB-TMCO4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for CAPZB-TMCO4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:19811930/chr1:20027378)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CAPZB P47756	.
FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269\|PubMed:21834987}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TMCO4

chr1:19811930

chr1:20009937

ENST00000294543

150_190

500

635.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TMCO4

chr1:19811930

chr1:20009937

ENST00000375122

150_190

460

595.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TMCO4

chr1:19811930

chr1:20009937

ENST00000294543

203_223

500

635.0

Transmembrane

Helical

Tgene

TMCO4

chr1:19811930

chr1:20009937

ENST00000294543

231_251

500

635.0

Transmembrane

Helical

Tgene

TMCO4

chr1:19811930

chr1:20009937

ENST00000294543

346_366

500

635.0

Transmembrane

Helical

Tgene

TMCO4

chr1:19811930

chr1:20009937

ENST00000375122

203_223

460

595.0

Transmembrane

Helical

Tgene

TMCO4

chr1:19811930

chr1:20009937

ENST00000375122

231_251

460

595.0

Transmembrane

Helical

Tgene

TMCO4

chr1:19811930

chr1:20009937

ENST00000375122

346_366

460

595.0

Transmembrane

Helical

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Fusion Gene Sequence for CAPZB-TMCO4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>13015_13015_1_CAPZB-TMCO4_CAPZB_chr1_19811930_ENST00000264202_TMCO4_chr1_20009937_ENST00000375127_length(transcript)=684nt_BP=52nt
GGGGAGAGCCACTGACGCCGGGACCGGGACCGCCGCCGCCGCCGCCACCATGGTCAGCGGCCACCTGGACTATGCCAAGCAGATGGATGC
CATCCTGAAGGCCGTGGGCATCCGCACCAAGCCAGGCTGGGACGAGAAGGGGCTCTTGCTGGCCCCAGGCTGCCTGCCCTCCGAGGAGCC
TCGCCAGGCAGCAGCTGCCGCCTCATCAGCTTTGGAGTCTGGCTGTCCATCAGGAGGTCCCGAGGGCTCTCTGGGGCCTGAGGCTCCCAC
ACCAGCTCTCCCCTGGCCTCAATAAAACCAGGTGCATGCCTGTTCTTCCATCCACACTCCAGGGCTGCCCACCAGCTGACAGGCACCATC
AACTGGCAGCAACAGAGCAGGCGCAGGTACAAAGAAGGCAGCTCACTCCTGCTCTTAGGAGATCCAATCAGATCTGCCCTGTACAGCCAT
GTAGGCTGTGCGCTGCATAACTCCAGGGACATGAGTCACACAGACACAATGTGAGTGTGCTCCCCCGTCATGCAACATCTGGACACCACT
AACAGAGCATGGTGAATACATGCTGAATTGCATTCAGTATGGCTGTGAACTAGGCCTGGGGACAAGAATGAATTTTACATGGAAAGAATT

>13015_13015_1_CAPZB-TMCO4_CAPZB_chr1_19811930_ENST00000264202_TMCO4_chr1_20009937_ENST00000375127_length(amino acids)=142AA_BP=0
MSLELCSAQPTWLYRADLIGSPKSRSELPSLYLRLLCCCQLMVPVSWWAALECGWKNRHAPGFIEARGELVWEPQAPESPRDLLMDSQTP

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>13015_13015_2_CAPZB-TMCO4_CAPZB_chr1_19811930_ENST00000375142_TMCO4_chr1_20009937_ENST00000375127_length(transcript)=682nt_BP=50nt
GGAGAGCCACTGACGCCGGGACCGGGACCGCCGCCGCCGCCGCCACCATGGTCAGCGGCCACCTGGACTATGCCAAGCAGATGGATGCCA
TCCTGAAGGCCGTGGGCATCCGCACCAAGCCAGGCTGGGACGAGAAGGGGCTCTTGCTGGCCCCAGGCTGCCTGCCCTCCGAGGAGCCTC
GCCAGGCAGCAGCTGCCGCCTCATCAGCTTTGGAGTCTGGCTGTCCATCAGGAGGTCCCGAGGGCTCTCTGGGGCCTGAGGCTCCCACAC
CAGCTCTCCCCTGGCCTCAATAAAACCAGGTGCATGCCTGTTCTTCCATCCACACTCCAGGGCTGCCCACCAGCTGACAGGCACCATCAA
CTGGCAGCAACAGAGCAGGCGCAGGTACAAAGAAGGCAGCTCACTCCTGCTCTTAGGAGATCCAATCAGATCTGCCCTGTACAGCCATGT
AGGCTGTGCGCTGCATAACTCCAGGGACATGAGTCACACAGACACAATGTGAGTGTGCTCCCCCGTCATGCAACATCTGGACACCACTAA
CAGAGCATGGTGAATACATGCTGAATTGCATTCAGTATGGCTGTGAACTAGGCCTGGGGACAAGAATGAATTTTACATGGAAAGAATTTC

>13015_13015_2_CAPZB-TMCO4_CAPZB_chr1_19811930_ENST00000375142_TMCO4_chr1_20009937_ENST00000375127_length(amino acids)=142AA_BP=0
MSLELCSAQPTWLYRADLIGSPKSRSELPSLYLRLLCCCQLMVPVSWWAALECGWKNRHAPGFIEARGELVWEPQAPESPRDLLMDSQTP

--------------------------------------------------------------
>13015_13015_3_CAPZB-TMCO4_CAPZB_chr1_19811930_ENST00000401084_TMCO4_chr1_20009937_ENST00000375127_length(transcript)=769nt_BP=137nt
GCCCGGCGCGGGGGGAGGGGGGTGCTGACCCGGATGTTCACTCCTGGGCACCCGGGGAAGTGGAAGCGCCGGGCCCTGCTGCGGGGGGGA
GAGCCACTGACGCCGGGACCGGGACCGCCGCCGCCGCCGCCACCATGGTCAGCGGCCACCTGGACTATGCCAAGCAGATGGATGCCATCC
TGAAGGCCGTGGGCATCCGCACCAAGCCAGGCTGGGACGAGAAGGGGCTCTTGCTGGCCCCAGGCTGCCTGCCCTCCGAGGAGCCTCGCC
AGGCAGCAGCTGCCGCCTCATCAGCTTTGGAGTCTGGCTGTCCATCAGGAGGTCCCGAGGGCTCTCTGGGGCCTGAGGCTCCCACACCAG
CTCTCCCCTGGCCTCAATAAAACCAGGTGCATGCCTGTTCTTCCATCCACACTCCAGGGCTGCCCACCAGCTGACAGGCACCATCAACTG
GCAGCAACAGAGCAGGCGCAGGTACAAAGAAGGCAGCTCACTCCTGCTCTTAGGAGATCCAATCAGATCTGCCCTGTACAGCCATGTAGG
CTGTGCGCTGCATAACTCCAGGGACATGAGTCACACAGACACAATGTGAGTGTGCTCCCCCGTCATGCAACATCTGGACACCACTAACAG
AGCATGGTGAATACATGCTGAATTGCATTCAGTATGGCTGTGAACTAGGCCTGGGGACAAGAATGAATTTTACATGGAAAGAATTTCCTG

>13015_13015_3_CAPZB-TMCO4_CAPZB_chr1_19811930_ENST00000401084_TMCO4_chr1_20009937_ENST00000375127_length(amino acids)=142AA_BP=0
MSLELCSAQPTWLYRADLIGSPKSRSELPSLYLRLLCCCQLMVPVSWWAALECGWKNRHAPGFIEARGELVWEPQAPESPRDLLMDSQTP

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Fusion Gene PPI Analysis for CAPZB-TMCO4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CAPZB-TMCO4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CAPZB-TMCO4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CAPZB	C0007097	Carcinoma	1	CTD_human
Hgene	CAPZB	C0024667	Animal Mammary Neoplasms	1	CTD_human
Hgene	CAPZB	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Hgene	CAPZB	C0205696	Anaplastic carcinoma	1	CTD_human
Hgene	CAPZB	C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Hgene	CAPZB	C0205698	Undifferentiated carcinoma	1	CTD_human
Hgene	CAPZB	C0205699	Carcinomatosis	1	CTD_human
Hgene	CAPZB	C0948089	Acute Coronary Syndrome	1	CTD_human
Hgene	CAPZB	C1257925	Mammary Carcinoma, Animal	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:CAPZB-TMCO4 (FusionGDB2 ID:HG832TG255104)

Fusion Gene Summary for CAPZB-TMCO4

Fusion Gene ORF analysis for CAPZB-TMCO4

Fusion Genomic Features for CAPZB-TMCO4

Fusion Protein Features for CAPZB-TMCO4

Fusion Gene Sequence for CAPZB-TMCO4

Fusion Gene PPI Analysis for CAPZB-TMCO4

Related Drugs for CAPZB-TMCO4

Related Diseases for CAPZB-TMCO4

Fusion Gene Studies
in Kim Lab