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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM103A1-IGF1R (FusionGDB2 ID:HG83640TG3480)

Fusion Gene Summary for FAM103A1-IGF1R

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM103A1-IGF1R
Fusion gene ID: hg83640tg3480
HgeneTgene
Gene symbol

FAM103A1

IGF1R

Gene ID

83640

3480

Gene nameRNA guanine-7 methyltransferase activating subunitinsulin like growth factor 1 receptor
SynonymsC15orf18|FAM103A1|HsT19360|RAM|RAMMETCD221|IGFIR|IGFR|JTK13
Cytomap('FAM103A1')('IGF1R')

15q25.2

15q26.3

Type of geneprotein-codingprotein-coding
DescriptionRNA guanine-N7 methyltransferase activating subunitRNMT activating mRNA cap methyltransferase subunitRNMT-activating mini proteinfamily with sequence similarity 103 member A1protein FAM103A1insulin-like growth factor 1 receptorIGF-I receptorsoluble IGF1R variant 1soluble IGF1R variant 2
Modification date2020031320200329
UniProtAcc.

P08069

Ensembl transtripts involved in fusion geneENST00000304191, 
Fusion gene scores* DoF score2 X 2 X 2=814 X 14 X 5=980
# samples 216
** MAII scorelog2(2/8*10)=1.32192809488736log2(16/980*10)=-2.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM103A1 [Title/Abstract] AND IGF1R [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM103A1(83656136)-IGF1R(99434554), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAM103A1

GO:0006370

7-methylguanosine mRNA capping

22099306

HgeneFAM103A1

GO:0036031

recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex

22099306

TgeneIGF1R

GO:0043066

negative regulation of apoptotic process

12556535

TgeneIGF1R

GO:0046328

regulation of JNK cascade

12556535

TgeneIGF1R

GO:0046777

protein autophosphorylation

1846292|7679099|11162456

TgeneIGF1R

GO:0048009

insulin-like growth factor receptor signaling pathway

7679099

TgeneIGF1R

GO:0048015

phosphatidylinositol-mediated signaling

7692086

TgeneIGF1R

GO:0051389

inactivation of MAPKK activity

12556535



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-GN-A26A-06AFAM103A1chr15

83656136

+IGF1Rchr15

99434554

+


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Fusion Gene ORF analysis for FAM103A1-IGF1R

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000304191ENST00000268035FAM103A1chr15

83656136

+IGF1Rchr15

99434554

+
5UTR-3CDSENST00000304191ENST00000558762FAM103A1chr15

83656136

+IGF1Rchr15

99434554

+
5UTR-3UTRENST00000304191ENST00000560432FAM103A1chr15

83656136

+IGF1Rchr15

99434554

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FAM103A1-IGF1R


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FAM103A1chr1583656136+IGF1Rchr1599434553+6.75E-070.9999993
FAM103A1chr1583656136+IGF1Rchr1599434553+6.75E-070.9999993


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FAM103A1-IGF1R


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:83656136/:99434554)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IGF1R

P08069

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FAM103A1-IGF1R


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FAM103A1-IGF1R


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM103A1-IGF1R


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneIGF1RP08069DB00046Insulin lisproBiotechApproved
TgeneIGF1RP08069DB00047Insulin glargineBiotechApproved
TgeneIGF1RP08069DB00071Insulin porkBiotechApproved
TgeneIGF1RP08069DB01306Insulin aspartBiotechApproved
TgeneIGF1RP08069DB01307Insulin detemirBiotechApproved
TgeneIGF1RP08069DB01309Insulin glulisineBiotechApproved
TgeneIGF1RP08069DB09564Insulin degludecBiotechApproved
TgeneIGF1RP08069DB14751Mecasermin rinfabateAgonistBiotechApproved
TgeneIGF1RP08069DB00030Insulin humanBiotechApproved|Investigational
TgeneIGF1RP08069DB01277MecaserminAgonistBiotechApproved|Investigational
TgeneIGF1RP08069DB06343TeprotumumabInhibitorBiotechApproved|Investigational
TgeneIGF1RP08069DB12267BrigatinibInhibitorSmall moleculeApproved|Investigational
TgeneIGF1RP08069DB09098SomatremBiotechApproved|Investigational|Withdrawn

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Related Diseases for FAM103A1-IGF1R


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1849157Resistance to Insulin-Like Growth Factor I5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0004238Atrial Fibrillation2CTD_human
TgeneC0024115Lung diseases2CTD_human
TgeneC0235480Paroxysmal atrial fibrillation2CTD_human
TgeneC0235833Congenital diaphragmatic hernia2CTD_human
TgeneC0265699Congenital hernia of foramen of Morgagni2CTD_human
TgeneC0265700Congenital hernia of foramen of Bochdalek2CTD_human
TgeneC2239176Liver carcinoma2CTD_human
TgeneC2585653Persistent atrial fibrillation2CTD_human
TgeneC3468561familial atrial fibrillation2CTD_human
TgeneC0002395Alzheimer's Disease1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007114Malignant neoplasm of skin1CTD_human
TgeneC0007621Neoplastic Cell Transformation1CTD_human
TgeneC0011265Presenile dementia1CTD_human
TgeneC0014170Endometrial Neoplasms1CTD_human
TgeneC0015934Fetal Growth Retardation1CTD_human
TgeneC0018273Growth Disorders1CTD_human
TgeneC0030567Parkinson Disease1CTD_human
TgeneC0035229Respiratory Insufficiency1CTD_human
TgeneC0037286Skin Neoplasms1CTD_human
TgeneC0087031Juvenile-Onset Still Disease1CTD_human
TgeneC0206686Adrenocortical carcinoma1CTD_human
TgeneC0235063Respiratory Depression1CTD_human
TgeneC0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneC0424605Developmental delay (disorder)1GENOMICS_ENGLAND
TgeneC0476089Endometrial Carcinoma1CTD_human
TgeneC0494463Alzheimer Disease, Late Onset1CTD_human
TgeneC0546126Acute Confusional Senile Dementia1CTD_human
TgeneC0557874Global developmental delay1GENOMICS_ENGLAND
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneC0752347Lewy Body Disease1CTD_human
TgeneC1145670Respiratory Failure1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC3495559Juvenile arthritis1CTD_human
TgeneC3714758Juvenile psoriatic arthritis1CTD_human
TgeneC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human
TgeneC4721453Peripheral Nervous System Diseases1CTD_human