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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ESPN-FBLIM1 (FusionGDB2 ID:HG83715TG54751)

Fusion Gene Summary for ESPN-FBLIM1

check button Fusion gene summary
Fusion gene informationFusion gene name: ESPN-FBLIM1
Fusion gene ID: hg83715tg54751
HgeneTgene
Gene symbol

ESPN

FBLIM1

Gene ID

83715

54751

Gene nameespinfilamin binding LIM protein 1
SynonymsDFNB36|LP2654|USH1MCAL|FBLP-1|FBLP1
Cytomap('ESPN')('FBLIM1')

1p36.31

1p36.21

Type of geneprotein-codingprotein-coding
Descriptionespinautosomal recessive deafness type 36 proteinectoplasmic specialization proteinfilamin-binding LIM protein 1CSX-associated LIMMIG2-interacting proteinmigfilinmitogen-inducible 2 interacting protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000475228, ENST00000377828, 
ENST00000416731, ENST00000461727, 
Fusion gene scores* DoF score2 X 3 X 2=125 X 7 X 6=210
# samples 28
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ESPN [Title/Abstract] AND FBLIM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointESPN(6520170)-FBLIM1(16111043), # samples:1
ESPN(6517432)-FBLIM1(16111043), # samples:1
Anticipated loss of major functional domain due to fusion event.ESPN-FBLIM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ESPN-FBLIM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ESPN-FBLIM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ESPN-FBLIM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ESPN-FBLIM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ESPN-FBLIM1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ESPN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FBLIM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-5366-01AESPNchr1

6517432

-FBLIM1chr1

16111043

+
ChimerDB4HNSCTCGA-CN-5366-01AESPNchr1

6520170

+FBLIM1chr1

16111043

+


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Fusion Gene ORF analysis for ESPN-FBLIM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000475228ENST00000375766ESPNchr1

6517432

-FBLIM1chr1

16111043

+
3UTR-3CDSENST00000475228ENST00000375771ESPNchr1

6517432

-FBLIM1chr1

16111043

+
3UTR-3CDSENST00000475228ENST00000400773ESPNchr1

6517432

-FBLIM1chr1

16111043

+
3UTR-3UTRENST00000475228ENST00000509138ESPNchr1

6517432

-FBLIM1chr1

16111043

+
3UTR-intronENST00000475228ENST00000332305ESPNchr1

6517432

-FBLIM1chr1

16111043

+
3UTR-intronENST00000475228ENST00000441801ESPNchr1

6517432

-FBLIM1chr1

16111043

+
5CDS-3UTRENST00000377828ENST00000509138ESPNchr1

6517432

-FBLIM1chr1

16111043

+
5CDS-3UTRENST00000377828ENST00000509138ESPNchr1

6520170

+FBLIM1chr1

16111043

+
5CDS-3UTRENST00000416731ENST00000509138ESPNchr1

6517432

-FBLIM1chr1

16111043

+
5CDS-3UTRENST00000416731ENST00000509138ESPNchr1

6520170

+FBLIM1chr1

16111043

+
5CDS-3UTRENST00000461727ENST00000509138ESPNchr1

6517432

-FBLIM1chr1

16111043

+
5CDS-3UTRENST00000461727ENST00000509138ESPNchr1

6520170

+FBLIM1chr1

16111043

+
5CDS-intronENST00000377828ENST00000332305ESPNchr1

6517432

-FBLIM1chr1

16111043

+
5CDS-intronENST00000377828ENST00000332305ESPNchr1

6520170

+FBLIM1chr1

16111043

+
5CDS-intronENST00000377828ENST00000441801ESPNchr1

6517432

-FBLIM1chr1

16111043

+
5CDS-intronENST00000377828ENST00000441801ESPNchr1

6520170

+FBLIM1chr1

16111043

+
5CDS-intronENST00000416731ENST00000332305ESPNchr1

6517432

-FBLIM1chr1

16111043

+
5CDS-intronENST00000416731ENST00000332305ESPNchr1

6520170

+FBLIM1chr1

16111043

+
5CDS-intronENST00000416731ENST00000441801ESPNchr1

6517432

-FBLIM1chr1

16111043

+
5CDS-intronENST00000416731ENST00000441801ESPNchr1

6520170

+FBLIM1chr1

16111043

+
5CDS-intronENST00000461727ENST00000332305ESPNchr1

6517432

-FBLIM1chr1

16111043

+
5CDS-intronENST00000461727ENST00000332305ESPNchr1

6520170

+FBLIM1chr1

16111043

+
5CDS-intronENST00000461727ENST00000441801ESPNchr1

6517432

-FBLIM1chr1

16111043

+
5CDS-intronENST00000461727ENST00000441801ESPNchr1

6520170

+FBLIM1chr1

16111043

+
Frame-shiftENST00000377828ENST00000375766ESPNchr1

6520170

+FBLIM1chr1

16111043

+
Frame-shiftENST00000377828ENST00000375771ESPNchr1

6520170

+FBLIM1chr1

16111043

+
Frame-shiftENST00000377828ENST00000400773ESPNchr1

6517432

-FBLIM1chr1

16111043

+
Frame-shiftENST00000377828ENST00000400773ESPNchr1

6520170

+FBLIM1chr1

16111043

+
Frame-shiftENST00000416731ENST00000375766ESPNchr1

6520170

+FBLIM1chr1

16111043

+
Frame-shiftENST00000416731ENST00000375771ESPNchr1

6520170

+FBLIM1chr1

16111043

+
Frame-shiftENST00000416731ENST00000400773ESPNchr1

6517432

-FBLIM1chr1

16111043

+
Frame-shiftENST00000416731ENST00000400773ESPNchr1

6520170

+FBLIM1chr1

16111043

+
Frame-shiftENST00000461727ENST00000375766ESPNchr1

6520170

+FBLIM1chr1

16111043

+
Frame-shiftENST00000461727ENST00000375771ESPNchr1

6520170

+FBLIM1chr1

16111043

+
Frame-shiftENST00000461727ENST00000400773ESPNchr1

6517432

-FBLIM1chr1

16111043

+
Frame-shiftENST00000461727ENST00000400773ESPNchr1

6520170

+FBLIM1chr1

16111043

+
In-frameENST00000377828ENST00000375766ESPNchr1

6517432

-FBLIM1chr1

16111043

+
In-frameENST00000377828ENST00000375771ESPNchr1

6517432

-FBLIM1chr1

16111043

+
In-frameENST00000416731ENST00000375766ESPNchr1

6517432

-FBLIM1chr1

16111043

+
In-frameENST00000416731ENST00000375771ESPNchr1

6517432

-FBLIM1chr1

16111043

+
In-frameENST00000461727ENST00000375766ESPNchr1

6517432

-FBLIM1chr1

16111043

+
In-frameENST00000461727ENST00000375771ESPNchr1

6517432

-FBLIM1chr1

16111043

+
intron-3CDSENST00000475228ENST00000375766ESPNchr1

6520170

+FBLIM1chr1

16111043

+
intron-3CDSENST00000475228ENST00000375771ESPNchr1

6520170

+FBLIM1chr1

16111043

+
intron-3CDSENST00000475228ENST00000400773ESPNchr1

6520170

+FBLIM1chr1

16111043

+
intron-3UTRENST00000475228ENST00000509138ESPNchr1

6520170

+FBLIM1chr1

16111043

+
intron-intronENST00000475228ENST00000332305ESPNchr1

6520170

+FBLIM1chr1

16111043

+
intron-intronENST00000475228ENST00000441801ESPNchr1

6520170

+FBLIM1chr1

16111043

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377828ESPNchr16517432-ENST00000375771FBLIM1chr116111043+463225851682639823
ENST00000377828ESPNchr16517432-ENST00000375766FBLIM1chr116111043+463225851682639823
ENST00000461727ESPNchr16517432-ENST00000375771FBLIM1chr116111043+298593824992322
ENST00000461727ESPNchr16517432-ENST00000375766FBLIM1chr116111043+298593824992322
ENST00000416731ESPNchr16517432-ENST00000375771FBLIM1chr116111043+27667190773257
ENST00000416731ESPNchr16517432-ENST00000375766FBLIM1chr116111043+27667190773257

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377828ENST00000375771ESPNchr16517432-FBLIM1chr116111043+0.0229046590.97709537
ENST00000377828ENST00000375766ESPNchr16517432-FBLIM1chr116111043+0.0229046590.97709537
ENST00000461727ENST00000375771ESPNchr16517432-FBLIM1chr116111043+0.076538320.92346174
ENST00000461727ENST00000375766ESPNchr16517432-FBLIM1chr116111043+0.076538320.92346174
ENST00000416731ENST00000375771ESPNchr16517432-FBLIM1chr116111043+0.076565720.92343426
ENST00000416731ENST00000375766ESPNchr16517432-FBLIM1chr116111043+0.076565720.92343426

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Fusion Genomic Features for ESPN-FBLIM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ESPN-FBLIM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:6520170/chr1:16111043)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESPNchr1:6517432chr1:16111043ENST00000377828-1213428_730805855.0Compositional biasNote=Pro-rich
HgeneESPNchr1:6517432chr1:16111043ENST00000377828-1213651_668805855.0DomainWH2
HgeneESPNchr1:6517432chr1:16111043ENST00000377828-1213103_133805855.0RepeatNote=ANK 4
HgeneESPNchr1:6517432chr1:16111043ENST00000377828-1213137_167805855.0RepeatNote=ANK 5
HgeneESPNchr1:6517432chr1:16111043ENST00000377828-1213171_201805855.0RepeatNote=ANK 6
HgeneESPNchr1:6517432chr1:16111043ENST00000377828-12131_31805855.0RepeatNote=ANK 1
HgeneESPNchr1:6517432chr1:16111043ENST00000377828-1213205_235805855.0RepeatNote=ANK 7
HgeneESPNchr1:6517432chr1:16111043ENST00000377828-1213239_268805855.0RepeatNote=ANK 8
HgeneESPNchr1:6517432chr1:16111043ENST00000377828-1213271_300805855.0RepeatNote=ANK 9
HgeneESPNchr1:6517432chr1:16111043ENST00000377828-121335_64805855.0RepeatNote=ANK 2
HgeneESPNchr1:6517432chr1:16111043ENST00000377828-121369_99805855.0RepeatNote=ANK 3
HgeneESPNchr1:6517432chr1:16111043ENST00000416731-67103_133239289.0RepeatNote=ANK 4
HgeneESPNchr1:6517432chr1:16111043ENST00000416731-67137_167239289.0RepeatNote=ANK 5
HgeneESPNchr1:6517432chr1:16111043ENST00000416731-67171_201239289.0RepeatNote=ANK 6
HgeneESPNchr1:6517432chr1:16111043ENST00000416731-671_31239289.0RepeatNote=ANK 1
HgeneESPNchr1:6517432chr1:16111043ENST00000416731-67205_235239289.0RepeatNote=ANK 7
HgeneESPNchr1:6517432chr1:16111043ENST00000416731-6735_64239289.0RepeatNote=ANK 2
HgeneESPNchr1:6517432chr1:16111043ENST00000416731-6769_99239289.0RepeatNote=ANK 3
HgeneESPNchr1:6517432chr1:16111043ENST00000461727-78103_133239289.0RepeatNote=ANK 4
HgeneESPNchr1:6517432chr1:16111043ENST00000461727-78137_167239289.0RepeatNote=ANK 5
HgeneESPNchr1:6517432chr1:16111043ENST00000461727-78171_201239289.0RepeatNote=ANK 6
HgeneESPNchr1:6517432chr1:16111043ENST00000461727-781_31239289.0RepeatNote=ANK 1
HgeneESPNchr1:6517432chr1:16111043ENST00000461727-78205_235239289.0RepeatNote=ANK 7
HgeneESPNchr1:6517432chr1:16111043ENST00000461727-7835_64239289.0RepeatNote=ANK 2
HgeneESPNchr1:6517432chr1:16111043ENST00000461727-7869_99239289.0RepeatNote=ANK 3
TgeneFBLIM1chr1:6517432chr1:16111043ENST000004418010642_1730375.0Compositional biasNote=Pro-rich
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000033230535243_300239277.0DomainLIM zinc-binding 2
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000033230535301_370239277.0DomainLIM zinc-binding 3
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000040077357243_300239277.0DomainLIM zinc-binding 2
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000040077357301_370239277.0DomainLIM zinc-binding 3
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000044180106181_2420375.0DomainLIM zinc-binding 1
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000044180106243_3000375.0DomainLIM zinc-binding 2
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000044180106301_3700375.0DomainLIM zinc-binding 3
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000033230535276_373239277.0RegionNote=FERMT2-binding
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000040077357276_373239277.0RegionNote=FERMT2-binding
TgeneFBLIM1chr1:6517432chr1:16111043ENST00000441801061_700375.0RegionNote=Filamin-binding
TgeneFBLIM1chr1:6517432chr1:16111043ENST00000441801061_850375.0RegionNote=Intrinsically disordered
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000044180106276_3730375.0RegionNote=FERMT2-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESPNchr1:6517432chr1:16111043ENST00000377828-1213756_830805855.0Coiled coilOntology_term=ECO:0000255
HgeneESPNchr1:6517432chr1:16111043ENST00000416731-67756_830239289.0Coiled coilOntology_term=ECO:0000255
HgeneESPNchr1:6517432chr1:16111043ENST00000461727-78756_830239289.0Coiled coilOntology_term=ECO:0000255
HgeneESPNchr1:6517432chr1:16111043ENST00000377828-1213768_825805855.0Compositional biasNote=Glu-rich
HgeneESPNchr1:6517432chr1:16111043ENST00000416731-67428_730239289.0Compositional biasNote=Pro-rich
HgeneESPNchr1:6517432chr1:16111043ENST00000416731-67768_825239289.0Compositional biasNote=Glu-rich
HgeneESPNchr1:6517432chr1:16111043ENST00000461727-78428_730239289.0Compositional biasNote=Pro-rich
HgeneESPNchr1:6517432chr1:16111043ENST00000461727-78768_825239289.0Compositional biasNote=Glu-rich
HgeneESPNchr1:6517432chr1:16111043ENST00000416731-67651_668239289.0DomainWH2
HgeneESPNchr1:6517432chr1:16111043ENST00000461727-78651_668239289.0DomainWH2
HgeneESPNchr1:6517432chr1:16111043ENST00000416731-67239_268239289.0RepeatNote=ANK 8
HgeneESPNchr1:6517432chr1:16111043ENST00000416731-67271_300239289.0RepeatNote=ANK 9
HgeneESPNchr1:6517432chr1:16111043ENST00000461727-78239_268239289.0RepeatNote=ANK 8
HgeneESPNchr1:6517432chr1:16111043ENST00000461727-78271_300239289.0RepeatNote=ANK 9
TgeneFBLIM1chr1:6517432chr1:16111043ENST000003323053542_173239277.0Compositional biasNote=Pro-rich
TgeneFBLIM1chr1:6517432chr1:16111043ENST000003757667942_173336374.0Compositional biasNote=Pro-rich
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000037577181042_173336374.0Compositional biasNote=Pro-rich
TgeneFBLIM1chr1:6517432chr1:16111043ENST000004007735742_173239277.0Compositional biasNote=Pro-rich
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000033230535181_242239277.0DomainLIM zinc-binding 1
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000037576679181_242336374.0DomainLIM zinc-binding 1
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000037576679243_300336374.0DomainLIM zinc-binding 2
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000037576679301_370336374.0DomainLIM zinc-binding 3
TgeneFBLIM1chr1:6517432chr1:16111043ENST00000375771810181_242336374.0DomainLIM zinc-binding 1
TgeneFBLIM1chr1:6517432chr1:16111043ENST00000375771810243_300336374.0DomainLIM zinc-binding 2
TgeneFBLIM1chr1:6517432chr1:16111043ENST00000375771810301_370336374.0DomainLIM zinc-binding 3
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000040077357181_242239277.0DomainLIM zinc-binding 1
TgeneFBLIM1chr1:6517432chr1:16111043ENST00000332305351_70239277.0RegionNote=Filamin-binding
TgeneFBLIM1chr1:6517432chr1:16111043ENST00000332305351_85239277.0RegionNote=Intrinsically disordered
TgeneFBLIM1chr1:6517432chr1:16111043ENST00000375766791_70336374.0RegionNote=Filamin-binding
TgeneFBLIM1chr1:6517432chr1:16111043ENST00000375766791_85336374.0RegionNote=Intrinsically disordered
TgeneFBLIM1chr1:6517432chr1:16111043ENST0000037576679276_373336374.0RegionNote=FERMT2-binding
TgeneFBLIM1chr1:6517432chr1:16111043ENST000003757718101_70336374.0RegionNote=Filamin-binding
TgeneFBLIM1chr1:6517432chr1:16111043ENST000003757718101_85336374.0RegionNote=Intrinsically disordered
TgeneFBLIM1chr1:6517432chr1:16111043ENST00000375771810276_373336374.0RegionNote=FERMT2-binding
TgeneFBLIM1chr1:6517432chr1:16111043ENST00000400773571_70239277.0RegionNote=Filamin-binding
TgeneFBLIM1chr1:6517432chr1:16111043ENST00000400773571_85239277.0RegionNote=Intrinsically disordered


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Fusion Gene Sequence for ESPN-FBLIM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27531_27531_1_ESPN-FBLIM1_ESPN_chr1_6517432_ENST00000377828_FBLIM1_chr1_16111043_ENST00000375766_length(transcript)=4632nt_BP=2585nt
AGCGGAGCGCCAGGCAGCGCGGAGCGGAGGCCAGGCCCACAGCCGCTCCGCCTCCCGGCCCGCAGATCCCCGACGGCCGCACCGCGGGCT
CCTCTGGCCCGCAAGAACACGTGCATGGCGTCCTGGGGAAGGCGCTGAGTGCGGAGTCGCGGCGCCGCACGCGGCACCATGGCCCTGGAG
CAGGCGCTGCAGGCGGCGCGGCAGGGCGAGCTGGACGTGCTGAGGTCGCTGCACGCCGCAGGCCTCCTGGGGCCCTCGCTGCGCGACCCG
CTGGACGCGCTGCCCGTGCACCACGCGGCCCGCGCTGGGAAGCTGCACTGTCTGCGCTTCCTGGTGGAGGAAGCCGCCCTCCCCGCCGCG
GCCCGCGCCCGCAACGGCGCCACACCGGCCCACGACGCCTCCGCCACCGGCCACCTCGCCTGCCTGCAGTGGCTGCTGTCGCAGGGCGGC
TGCAGAGTGCAGGACAAAGACAATTCTGGTGCCACAGTCTTGCATCTGGCTGCCCGCTTCGGCCACCCCGAGGTGGTGAACTGGCTCTTG
CATCATGGCGGTGGGGACCCCACCGCGGCCACAGACATGGGCGCCCTGCCTATCCACTACGCTGCCGCCAAAGGAGACTTCCCCTCCCTG
AGGCTTCTCGTCGAGCACTACCCTGAGGGAGTGAATGCCCAAACCAAGAACGGTGCCACGCCCCTGTACCTGGCGTGCCAGGAGGGCCAC
CTGGAGGTGACCCAGTACCTGGTGCAGGAATGCGGCGCAGACCCGCACGCGCGCGCCCACGACGGCATGACCCCGCTGCACGCCGCGGCG
CAGATGGGCCACAGCCCAGTCATCGTGTGGTTGGTGAGCTGCACCGACGTGAGCCTGTCCGAGCAGGACAAAGACGGCGCCACCGCCATG
CACTTCGCGGCGAGCCGCGGCCACACCAAGGTGCTCAGCTGGCTGCTGCTGCACGGCGGGGAGATCTCGGCTGACCTGTGGGGCGGGACC
CCGCTGCACGACGCCGCCGAGAACGGGGAGCTAGAGTGCTGCCAGATCCTGGTAGTGAACGGCGCGGAGCTGGACGTCCGCGACCGCGAC
GGGTACACGGCCGCCGACCTGTCGGACTTCAACGGCCACAGCCACTGCACCCGCTACCTGCGCACGGTGGAGAACCTGAGCGTGGAGCAC
CGCGTGCTTTCCCGGGATCCATCCGCAGAGCTGGAGGCTAAGCAGCCGGATTCAGGCATGTCCTCACCCAATACCACGGTGTCGGTCCAG
CCGCTGAACTTTGACCTCAGCTCGCCTACCAGCACCCTCTCCAACTACGACTCCTGCTCCTCCAGCCACTCCAGCATCAAGGGCCAGCAC
CCTCCATGTGGGCTTTCCAGCGCTAGAGCTGCAGACATACAGAGCTACATGGACATGCTGAACCCGGAGCTGGGCCTGCCTCGGGGCACG
ATTGGGAAGCCCACACCCCCACCACCCCCACCCAGCTTCCCCCCGCCACCCCCGCCCCCAGGCACCCAACTGCCCCCACCCCCACCTGGC
TACCCAGCTCCCAAGCCTCCTGTAGGACCACAGGCAGCTGACATCTACATGCAGACCAAGAACAAACTCCGCCACGTGGAGACAGAGGCC
CTCAAGAAGGAGCTGAGCTCCTGTGACGGCCACGACGGGCTGCGGAGGCAGGACTCCAGCCGCAAGCCCCGCGCCTTCAGCAAGCAGCCC
AGCACGGGGGACTACTACCGGCAGCTGGGCCGCTGCCCCGGCGAGACGCTGGCCGCACGCCCGGGCATGGCGCACAGCGAGGAGGTGCGT
GCCCGCCAGCCCGCGCGCGCCGGCTGCCCGCGCCTCGGCCCTGCCGCCCGCGGCTCACTCGAAGGCCCCTCCGCTCCCCCGCAGGCGGCG
CTGCTTCCTGGGAACCATGTTCCTAACGGCTGCGCCGCGGACCCCAAGGCGTCCAGGGAGCTGCCACCGCCGCCCCCACCGCCGCCGCCG
CCCCTGCCGGAGGCCGCGAGTTCGCCACCGCCGGCCCCGCCTCTGCCCCTCGAGAGCGCTGGCCCTGGCTGCGGGCAGCGCCGCTCCTCC
TCGTCCACCGGCAGCACCAAGTCTTTCAACATGATGTCCCCGACGGGCGACAACTCGGAGCTACTGGCTGAGATTAAGGCAGGCAAGAGC
CTGAAGCCGACGCCCCAGAGCAAGGGGCTGACCACAGTGTTCTCAGGCATCGGGCAGCCGGCCTTCCAGCCCGATTCGCCGCTGCCTTCT
GTGTCACCTGCACTGTCACCAGTCCGGAGCCCCACACCGCCAGCTGCGGGGTTTCAGCCGCTGCTCAATGGAAGCTTGGTTCCCGTGCCG
CCCACTACTCCTGCGCCGGGAGTGCAGCTGGACGTGGAGGCTCTCATCCCCACGCACGATGAGCAGGGCCGGCCCATCCCCGAGTGGAAG
CGCCAGGTGATGGTGCGCAAGATGCAGCTGAAGATGCAGGAGGAGGAGGAGCAGAGGCGGAAGGAGGAGGAGGAGGAGGCCCGGCTGGCC
AGCATGCCCGCCTGGAGGCGGGACCTCCTGCGGAAGAAGCTGGAAGAAGAGAGGGAGCAGAAGCGGACTGCAGGATCCTCCTGTCTGTCG
AGCCCACGGACCAAGGCTGCTACCCCCTGAACAACCATCTCTTCTGCAAGCCATGCCATGTGAAGCGGAGTGCTGCGGGGTGCTGCTGAG
AGTGCCCGCTGGGCAGTGAACAGACCACTAGCCCCGGCTGGGGCCCTTCCCTGACTTGGTTTCCCTTCCTAACCTGCTCTTGCACACTTT
CCTTCTGAGCCTCCATGGAGACCAGCCTGCAAGCCGGCCCAGCCTGTCCAGGATACAGTGGGGCTGAGCACCCCCAGGCCTTCCACTCCT
CTACCCTCTGGGCACCAGAAGGCTCCTGGACCATGAGCTTCACCCCCAGAATTCCCTGCTGACCCTGCCCCACTTCCAGGGAAAAGCTGG
GGGAGGTTGGACCCCTCTCACTGACTAGCTGTCTGGTAGGGGTGCTAGGACCAGCCTCGCCTGTGGGGTTGAGCTGTTTGAGGACAAACT
CCAAGGTCCCTTAAAAAGTGCCTTTTAGAGGCTGGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGAT
CACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTAGC
AGGTGCCTGTAATCCCAGCTACTGGGGAAAGCTGAGGCAGGAGAATTGCTTCAATCTGGAAGGCAGAGGTTGCAGTGAGATTGCACCATT
GCATTCCAGCCTGGGCAACAAGAGGGAAACTCCGTCTCAAAAAAAAAAAAGTGCCTTTTAGGCCGGATGTGGTGGCTCATGCCTGTAATC
CCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACACGGCAAAACCCCGTTTCTACT
AAAAATACAAAAATTAGCTGGGTGTGGTGGCGTGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGCATTGCTTGAACCCGGG
AGGCAGAGGTTGCAGTGAGCTGAGATGGCACCACTGCACTCCAGCCTGGGAGACACAGCGAGACTCTGTCTCCAAAAAAAAAAGTGCTTT
TTGAAAATGTTGAGGTTGAAATGATGGGAACCAACATTCTTTGGATTTAGTGGGGAGCATAATAGCAAACACCCCCTTGGTTCGCACATG
TACAGGAATGGGACCCAGTTGGGGCACAGCCATGGACTTCCCCGCCCTGGAATGTGTGGTGCAAAGTGGGGCCAGGGCCCAGACCCAAGA
GGAGAGGGTGGTCCGCAGACACCCCGGGATGTCAGCATCCCCCGACCTGCCTTCTGGCGGCACCTCCCGGGTGCTGTGTTGAGTCAGCAG
GCATGGGGTGAGAGCCTGGTATATGCTGGGAACAGGGTGCAGGGGCCAAGCGTTCCTCCTTCAGCCTTGACTTGGGCCATGCACCCCCTC
TCCCCCAAACACAAACAAGCACTTCTCCAGTATGGTGCCAGGACAGGTGTCCCTTCAGTCCTCTGGTTATGACCTCAAGTCCTACTTGGG
CCCTGCAGCCCAGCCTGTGTTGTAACCTCTGCGTCCTCAAGACCACACCTGGAAGATTCTTCTTCCCTTTGAAGGAGAATCATCATTGTT
GCTTTATCACTTCTAAGACATTTTGTACGGCACGGACAAGTTAAACAGAATGTGCTTCCCTCCCTGGGGTCTCACACGCTCCCACGAGAA
TGCCACAGGGGCCGTGCACTGGGCAGGCTTCTCTGTAGAACCCCAGGGGCTTCGGCCCAGACCACAGCGTCTTGCCCTGAGCCTAGAGCA
GGGAGTCCCGAACTTCTGCATTCACAGACCACCTCCACAATTGTTATAACCAAAGGCCTCCTGTTCTGTTATTTCACTTAAATCAACATG
CTATTTTGTTTTCACTCACTTCTGACTTTAGCCTCGTGCTGAGCCGTGTATCCATGCAGTCATGTTCACGTGCTAGTTACGTTTTTCTTC
TTACACATGAAAATAAATGCATAAGTGTTAGAAGCTCTTCCA

>27531_27531_1_ESPN-FBLIM1_ESPN_chr1_6517432_ENST00000377828_FBLIM1_chr1_16111043_ENST00000375766_length(amino acids)=823AA_BP=805
MALEQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLL
SQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLAC
QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADL
WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTT
VSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQHPPCGLSSARAADIQSYMDMLNPELGLPRGTIGKPTPPPPPPSFPPPPPPPGTQLPP
PPPGYPAPKPPVGPQAADIYMQTKNKLRHVETEALKKELSSCDGHDGLRRQDSSRKPRAFSKQPSTGDYYRQLGRCPGETLAARPGMAHS
EEVRARQPARAGCPRLGPAARGSLEGPSAPPQAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAASSPPPAPPLPLESAGPGCGQ
RRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSL
VPVPPTTPAPGVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEEEEARLASMPAWRRDLLRKKLEEEREQKRTAGS
SCLSSPRTKAATP

--------------------------------------------------------------
>27531_27531_2_ESPN-FBLIM1_ESPN_chr1_6517432_ENST00000377828_FBLIM1_chr1_16111043_ENST00000375771_length(transcript)=4632nt_BP=2585nt
AGCGGAGCGCCAGGCAGCGCGGAGCGGAGGCCAGGCCCACAGCCGCTCCGCCTCCCGGCCCGCAGATCCCCGACGGCCGCACCGCGGGCT
CCTCTGGCCCGCAAGAACACGTGCATGGCGTCCTGGGGAAGGCGCTGAGTGCGGAGTCGCGGCGCCGCACGCGGCACCATGGCCCTGGAG
CAGGCGCTGCAGGCGGCGCGGCAGGGCGAGCTGGACGTGCTGAGGTCGCTGCACGCCGCAGGCCTCCTGGGGCCCTCGCTGCGCGACCCG
CTGGACGCGCTGCCCGTGCACCACGCGGCCCGCGCTGGGAAGCTGCACTGTCTGCGCTTCCTGGTGGAGGAAGCCGCCCTCCCCGCCGCG
GCCCGCGCCCGCAACGGCGCCACACCGGCCCACGACGCCTCCGCCACCGGCCACCTCGCCTGCCTGCAGTGGCTGCTGTCGCAGGGCGGC
TGCAGAGTGCAGGACAAAGACAATTCTGGTGCCACAGTCTTGCATCTGGCTGCCCGCTTCGGCCACCCCGAGGTGGTGAACTGGCTCTTG
CATCATGGCGGTGGGGACCCCACCGCGGCCACAGACATGGGCGCCCTGCCTATCCACTACGCTGCCGCCAAAGGAGACTTCCCCTCCCTG
AGGCTTCTCGTCGAGCACTACCCTGAGGGAGTGAATGCCCAAACCAAGAACGGTGCCACGCCCCTGTACCTGGCGTGCCAGGAGGGCCAC
CTGGAGGTGACCCAGTACCTGGTGCAGGAATGCGGCGCAGACCCGCACGCGCGCGCCCACGACGGCATGACCCCGCTGCACGCCGCGGCG
CAGATGGGCCACAGCCCAGTCATCGTGTGGTTGGTGAGCTGCACCGACGTGAGCCTGTCCGAGCAGGACAAAGACGGCGCCACCGCCATG
CACTTCGCGGCGAGCCGCGGCCACACCAAGGTGCTCAGCTGGCTGCTGCTGCACGGCGGGGAGATCTCGGCTGACCTGTGGGGCGGGACC
CCGCTGCACGACGCCGCCGAGAACGGGGAGCTAGAGTGCTGCCAGATCCTGGTAGTGAACGGCGCGGAGCTGGACGTCCGCGACCGCGAC
GGGTACACGGCCGCCGACCTGTCGGACTTCAACGGCCACAGCCACTGCACCCGCTACCTGCGCACGGTGGAGAACCTGAGCGTGGAGCAC
CGCGTGCTTTCCCGGGATCCATCCGCAGAGCTGGAGGCTAAGCAGCCGGATTCAGGCATGTCCTCACCCAATACCACGGTGTCGGTCCAG
CCGCTGAACTTTGACCTCAGCTCGCCTACCAGCACCCTCTCCAACTACGACTCCTGCTCCTCCAGCCACTCCAGCATCAAGGGCCAGCAC
CCTCCATGTGGGCTTTCCAGCGCTAGAGCTGCAGACATACAGAGCTACATGGACATGCTGAACCCGGAGCTGGGCCTGCCTCGGGGCACG
ATTGGGAAGCCCACACCCCCACCACCCCCACCCAGCTTCCCCCCGCCACCCCCGCCCCCAGGCACCCAACTGCCCCCACCCCCACCTGGC
TACCCAGCTCCCAAGCCTCCTGTAGGACCACAGGCAGCTGACATCTACATGCAGACCAAGAACAAACTCCGCCACGTGGAGACAGAGGCC
CTCAAGAAGGAGCTGAGCTCCTGTGACGGCCACGACGGGCTGCGGAGGCAGGACTCCAGCCGCAAGCCCCGCGCCTTCAGCAAGCAGCCC
AGCACGGGGGACTACTACCGGCAGCTGGGCCGCTGCCCCGGCGAGACGCTGGCCGCACGCCCGGGCATGGCGCACAGCGAGGAGGTGCGT
GCCCGCCAGCCCGCGCGCGCCGGCTGCCCGCGCCTCGGCCCTGCCGCCCGCGGCTCACTCGAAGGCCCCTCCGCTCCCCCGCAGGCGGCG
CTGCTTCCTGGGAACCATGTTCCTAACGGCTGCGCCGCGGACCCCAAGGCGTCCAGGGAGCTGCCACCGCCGCCCCCACCGCCGCCGCCG
CCCCTGCCGGAGGCCGCGAGTTCGCCACCGCCGGCCCCGCCTCTGCCCCTCGAGAGCGCTGGCCCTGGCTGCGGGCAGCGCCGCTCCTCC
TCGTCCACCGGCAGCACCAAGTCTTTCAACATGATGTCCCCGACGGGCGACAACTCGGAGCTACTGGCTGAGATTAAGGCAGGCAAGAGC
CTGAAGCCGACGCCCCAGAGCAAGGGGCTGACCACAGTGTTCTCAGGCATCGGGCAGCCGGCCTTCCAGCCCGATTCGCCGCTGCCTTCT
GTGTCACCTGCACTGTCACCAGTCCGGAGCCCCACACCGCCAGCTGCGGGGTTTCAGCCGCTGCTCAATGGAAGCTTGGTTCCCGTGCCG
CCCACTACTCCTGCGCCGGGAGTGCAGCTGGACGTGGAGGCTCTCATCCCCACGCACGATGAGCAGGGCCGGCCCATCCCCGAGTGGAAG
CGCCAGGTGATGGTGCGCAAGATGCAGCTGAAGATGCAGGAGGAGGAGGAGCAGAGGCGGAAGGAGGAGGAGGAGGAGGCCCGGCTGGCC
AGCATGCCCGCCTGGAGGCGGGACCTCCTGCGGAAGAAGCTGGAAGAAGAGAGGGAGCAGAAGCGGACTGCAGGATCCTCCTGTCTGTCG
AGCCCACGGACCAAGGCTGCTACCCCCTGAACAACCATCTCTTCTGCAAGCCATGCCATGTGAAGCGGAGTGCTGCGGGGTGCTGCTGAG
AGTGCCCGCTGGGCAGTGAACAGACCACTAGCCCCGGCTGGGGCCCTTCCCTGACTTGGTTTCCCTTCCTAACCTGCTCTTGCACACTTT
CCTTCTGAGCCTCCATGGAGACCAGCCTGCAAGCCGGCCCAGCCTGTCCAGGATACAGTGGGGCTGAGCACCCCCAGGCCTTCCACTCCT
CTACCCTCTGGGCACCAGAAGGCTCCTGGACCATGAGCTTCACCCCCAGAATTCCCTGCTGACCCTGCCCCACTTCCAGGGAAAAGCTGG
GGGAGGTTGGACCCCTCTCACTGACTAGCTGTCTGGTAGGGGTGCTAGGACCAGCCTCGCCTGTGGGGTTGAGCTGTTTGAGGACAAACT
CCAAGGTCCCTTAAAAAGTGCCTTTTAGAGGCTGGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGAT
CACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTAGC
AGGTGCCTGTAATCCCAGCTACTGGGGAAAGCTGAGGCAGGAGAATTGCTTCAATCTGGAAGGCAGAGGTTGCAGTGAGATTGCACCATT
GCATTCCAGCCTGGGCAACAAGAGGGAAACTCCGTCTCAAAAAAAAAAAAGTGCCTTTTAGGCCGGATGTGGTGGCTCATGCCTGTAATC
CCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACACGGCAAAACCCCGTTTCTACT
AAAAATACAAAAATTAGCTGGGTGTGGTGGCGTGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGCATTGCTTGAACCCGGG
AGGCAGAGGTTGCAGTGAGCTGAGATGGCACCACTGCACTCCAGCCTGGGAGACACAGCGAGACTCTGTCTCCAAAAAAAAAAGTGCTTT
TTGAAAATGTTGAGGTTGAAATGATGGGAACCAACATTCTTTGGATTTAGTGGGGAGCATAATAGCAAACACCCCCTTGGTTCGCACATG
TACAGGAATGGGACCCAGTTGGGGCACAGCCATGGACTTCCCCGCCCTGGAATGTGTGGTGCAAAGTGGGGCCAGGGCCCAGACCCAAGA
GGAGAGGGTGGTCCGCAGACACCCCGGGATGTCAGCATCCCCCGACCTGCCTTCTGGCGGCACCTCCCGGGTGCTGTGTTGAGTCAGCAG
GCATGGGGTGAGAGCCTGGTATATGCTGGGAACAGGGTGCAGGGGCCAAGCGTTCCTCCTTCAGCCTTGACTTGGGCCATGCACCCCCTC
TCCCCCAAACACAAACAAGCACTTCTCCAGTATGGTGCCAGGACAGGTGTCCCTTCAGTCCTCTGGTTATGACCTCAAGTCCTACTTGGG
CCCTGCAGCCCAGCCTGTGTTGTAACCTCTGCGTCCTCAAGACCACACCTGGAAGATTCTTCTTCCCTTTGAAGGAGAATCATCATTGTT
GCTTTATCACTTCTAAGACATTTTGTACGGCACGGACAAGTTAAACAGAATGTGCTTCCCTCCCTGGGGTCTCACACGCTCCCACGAGAA
TGCCACAGGGGCCGTGCACTGGGCAGGCTTCTCTGTAGAACCCCAGGGGCTTCGGCCCAGACCACAGCGTCTTGCCCTGAGCCTAGAGCA
GGGAGTCCCGAACTTCTGCATTCACAGACCACCTCCACAATTGTTATAACCAAAGGCCTCCTGTTCTGTTATTTCACTTAAATCAACATG
CTATTTTGTTTTCACTCACTTCTGACTTTAGCCTCGTGCTGAGCCGTGTATCCATGCAGTCATGTTCACGTGCTAGTTACGTTTTTCTTC
TTACACATGAAAATAAATGCATAAGTGTTAGAAGCTCTTCCA

>27531_27531_2_ESPN-FBLIM1_ESPN_chr1_6517432_ENST00000377828_FBLIM1_chr1_16111043_ENST00000375771_length(amino acids)=823AA_BP=805
MALEQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLL
SQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLAC
QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADL
WGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTT
VSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQHPPCGLSSARAADIQSYMDMLNPELGLPRGTIGKPTPPPPPPSFPPPPPPPGTQLPP
PPPGYPAPKPPVGPQAADIYMQTKNKLRHVETEALKKELSSCDGHDGLRRQDSSRKPRAFSKQPSTGDYYRQLGRCPGETLAARPGMAHS
EEVRARQPARAGCPRLGPAARGSLEGPSAPPQAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAASSPPPAPPLPLESAGPGCGQ
RRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSL
VPVPPTTPAPGVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEEEEARLASMPAWRRDLLRKKLEEEREQKRTAGS
SCLSSPRTKAATP

--------------------------------------------------------------
>27531_27531_3_ESPN-FBLIM1_ESPN_chr1_6517432_ENST00000416731_FBLIM1_chr1_16111043_ENST00000375766_length(transcript)=2766nt_BP=719nt
ATGGCGCACAGCGAGGAGGCGGCGCTGCTTCCTGGGAACCATGTTCCTAACGGCTGCGCCGCGGACCCCAAGGCGTCCAGGGAGCTGCCA
CCGCCGCCCCCACCGCCGCCGCCGCCCCTGCCGGAGGCCGCGAGTTCGCCACCGCCGGCCCCGCCTCTGCCCCTCGAGAGCGCTGGCCCT
GGCTGCGGGCAGCGCCGCTCCTCCTCGTCCACCGGCAGCACCAAGTCTTTCAACATGATGTCCCCGACGGGCGACAACTCGGAGCTACTG
GCTGAGATTAAGGCAGGCAAGAGCCTGAAGCCGACGCCCCAGAGCAAGGGGCTGACCACAGTGTTCTCAGGCATCGGGCAGCCGGCCTTC
CAGCCCGATTCGCCGCTGCCTTCTGTGTCACCTGCACTGTCACCAGTCCGGAGCCCCACACCGCCAGCTGCGGGGTTTCAGCCGCTGCTC
AATGGAAGCTTGGTTCCCGTGCCGCCCACTACTCCTGCGCCGGGAGTGCAGCTGGACGTGGAGGCTCTCATCCCCACGCACGATGAGCAG
GGCCGGCCCATCCCCGAGTGGAAGCGCCAGGTGATGGTGCGCAAGATGCAGCTGAAGATGCAGGAGGAGGAGGAGCAGAGGCGGAAGGAG
GAGGAGGAGGAGGCCCGGCTGGCCAGCATGCCCGCCTGGAGGCGGGACCTCCTGCGGAAGAAGCTGGAAGAAGAGAGGGAGCAGAAGCGG
ACTGCAGGATCCTCCTGTCTGTCGAGCCCACGGACCAAGGCTGCTACCCCCTGAACAACCATCTCTTCTGCAAGCCATGCCATGTGAAGC
GGAGTGCTGCGGGGTGCTGCTGAGAGTGCCCGCTGGGCAGTGAACAGACCACTAGCCCCGGCTGGGGCCCTTCCCTGACTTGGTTTCCCT
TCCTAACCTGCTCTTGCACACTTTCCTTCTGAGCCTCCATGGAGACCAGCCTGCAAGCCGGCCCAGCCTGTCCAGGATACAGTGGGGCTG
AGCACCCCCAGGCCTTCCACTCCTCTACCCTCTGGGCACCAGAAGGCTCCTGGACCATGAGCTTCACCCCCAGAATTCCCTGCTGACCCT
GCCCCACTTCCAGGGAAAAGCTGGGGGAGGTTGGACCCCTCTCACTGACTAGCTGTCTGGTAGGGGTGCTAGGACCAGCCTCGCCTGTGG
GGTTGAGCTGTTTGAGGACAAACTCCAAGGTCCCTTAAAAAGTGCCTTTTAGAGGCTGGGCATGGTGGCTCACGCTTGTAATCCCAGCAC
TTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATA
CAAAAATTAGCCAGGCATGGTAGCAGGTGCCTGTAATCCCAGCTACTGGGGAAAGCTGAGGCAGGAGAATTGCTTCAATCTGGAAGGCAG
AGGTTGCAGTGAGATTGCACCATTGCATTCCAGCCTGGGCAACAAGAGGGAAACTCCGTCTCAAAAAAAAAAAAGTGCCTTTTAGGCCGG
ATGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCA
ACACGGCAAAACCCCGTTTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGTGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAG
GCAGGAGCATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATGGCACCACTGCACTCCAGCCTGGGAGACACAGCGAGACTC
TGTCTCCAAAAAAAAAAGTGCTTTTTGAAAATGTTGAGGTTGAAATGATGGGAACCAACATTCTTTGGATTTAGTGGGGAGCATAATAGC
AAACACCCCCTTGGTTCGCACATGTACAGGAATGGGACCCAGTTGGGGCACAGCCATGGACTTCCCCGCCCTGGAATGTGTGGTGCAAAG
TGGGGCCAGGGCCCAGACCCAAGAGGAGAGGGTGGTCCGCAGACACCCCGGGATGTCAGCATCCCCCGACCTGCCTTCTGGCGGCACCTC
CCGGGTGCTGTGTTGAGTCAGCAGGCATGGGGTGAGAGCCTGGTATATGCTGGGAACAGGGTGCAGGGGCCAAGCGTTCCTCCTTCAGCC
TTGACTTGGGCCATGCACCCCCTCTCCCCCAAACACAAACAAGCACTTCTCCAGTATGGTGCCAGGACAGGTGTCCCTTCAGTCCTCTGG
TTATGACCTCAAGTCCTACTTGGGCCCTGCAGCCCAGCCTGTGTTGTAACCTCTGCGTCCTCAAGACCACACCTGGAAGATTCTTCTTCC
CTTTGAAGGAGAATCATCATTGTTGCTTTATCACTTCTAAGACATTTTGTACGGCACGGACAAGTTAAACAGAATGTGCTTCCCTCCCTG
GGGTCTCACACGCTCCCACGAGAATGCCACAGGGGCCGTGCACTGGGCAGGCTTCTCTGTAGAACCCCAGGGGCTTCGGCCCAGACCACA
GCGTCTTGCCCTGAGCCTAGAGCAGGGAGTCCCGAACTTCTGCATTCACAGACCACCTCCACAATTGTTATAACCAAAGGCCTCCTGTTC
TGTTATTTCACTTAAATCAACATGCTATTTTGTTTTCACTCACTTCTGACTTTAGCCTCGTGCTGAGCCGTGTATCCATGCAGTCATGTT
CACGTGCTAGTTACGTTTTTCTTCTTACACATGAAAATAAATGCATAAGTGTTAGAAGCTCTTCCA

>27531_27531_3_ESPN-FBLIM1_ESPN_chr1_6517432_ENST00000416731_FBLIM1_chr1_16111043_ENST00000375766_length(amino acids)=257AA_BP=239
MAHSEEAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAASSPPPAPPLPLESAGPGCGQRRSSSSTGSTKSFNMMSPTGDNSELL
AEIKAGKSLKPTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSLVPVPPTTPAPGVQLDVEALIPTHDEQ
GRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEEEEARLASMPAWRRDLLRKKLEEEREQKRTAGSSCLSSPRTKAATP

--------------------------------------------------------------
>27531_27531_4_ESPN-FBLIM1_ESPN_chr1_6517432_ENST00000416731_FBLIM1_chr1_16111043_ENST00000375771_length(transcript)=2766nt_BP=719nt
ATGGCGCACAGCGAGGAGGCGGCGCTGCTTCCTGGGAACCATGTTCCTAACGGCTGCGCCGCGGACCCCAAGGCGTCCAGGGAGCTGCCA
CCGCCGCCCCCACCGCCGCCGCCGCCCCTGCCGGAGGCCGCGAGTTCGCCACCGCCGGCCCCGCCTCTGCCCCTCGAGAGCGCTGGCCCT
GGCTGCGGGCAGCGCCGCTCCTCCTCGTCCACCGGCAGCACCAAGTCTTTCAACATGATGTCCCCGACGGGCGACAACTCGGAGCTACTG
GCTGAGATTAAGGCAGGCAAGAGCCTGAAGCCGACGCCCCAGAGCAAGGGGCTGACCACAGTGTTCTCAGGCATCGGGCAGCCGGCCTTC
CAGCCCGATTCGCCGCTGCCTTCTGTGTCACCTGCACTGTCACCAGTCCGGAGCCCCACACCGCCAGCTGCGGGGTTTCAGCCGCTGCTC
AATGGAAGCTTGGTTCCCGTGCCGCCCACTACTCCTGCGCCGGGAGTGCAGCTGGACGTGGAGGCTCTCATCCCCACGCACGATGAGCAG
GGCCGGCCCATCCCCGAGTGGAAGCGCCAGGTGATGGTGCGCAAGATGCAGCTGAAGATGCAGGAGGAGGAGGAGCAGAGGCGGAAGGAG
GAGGAGGAGGAGGCCCGGCTGGCCAGCATGCCCGCCTGGAGGCGGGACCTCCTGCGGAAGAAGCTGGAAGAAGAGAGGGAGCAGAAGCGG
ACTGCAGGATCCTCCTGTCTGTCGAGCCCACGGACCAAGGCTGCTACCCCCTGAACAACCATCTCTTCTGCAAGCCATGCCATGTGAAGC
GGAGTGCTGCGGGGTGCTGCTGAGAGTGCCCGCTGGGCAGTGAACAGACCACTAGCCCCGGCTGGGGCCCTTCCCTGACTTGGTTTCCCT
TCCTAACCTGCTCTTGCACACTTTCCTTCTGAGCCTCCATGGAGACCAGCCTGCAAGCCGGCCCAGCCTGTCCAGGATACAGTGGGGCTG
AGCACCCCCAGGCCTTCCACTCCTCTACCCTCTGGGCACCAGAAGGCTCCTGGACCATGAGCTTCACCCCCAGAATTCCCTGCTGACCCT
GCCCCACTTCCAGGGAAAAGCTGGGGGAGGTTGGACCCCTCTCACTGACTAGCTGTCTGGTAGGGGTGCTAGGACCAGCCTCGCCTGTGG
GGTTGAGCTGTTTGAGGACAAACTCCAAGGTCCCTTAAAAAGTGCCTTTTAGAGGCTGGGCATGGTGGCTCACGCTTGTAATCCCAGCAC
TTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATA
CAAAAATTAGCCAGGCATGGTAGCAGGTGCCTGTAATCCCAGCTACTGGGGAAAGCTGAGGCAGGAGAATTGCTTCAATCTGGAAGGCAG
AGGTTGCAGTGAGATTGCACCATTGCATTCCAGCCTGGGCAACAAGAGGGAAACTCCGTCTCAAAAAAAAAAAAGTGCCTTTTAGGCCGG
ATGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCA
ACACGGCAAAACCCCGTTTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGTGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAG
GCAGGAGCATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATGGCACCACTGCACTCCAGCCTGGGAGACACAGCGAGACTC
TGTCTCCAAAAAAAAAAGTGCTTTTTGAAAATGTTGAGGTTGAAATGATGGGAACCAACATTCTTTGGATTTAGTGGGGAGCATAATAGC
AAACACCCCCTTGGTTCGCACATGTACAGGAATGGGACCCAGTTGGGGCACAGCCATGGACTTCCCCGCCCTGGAATGTGTGGTGCAAAG
TGGGGCCAGGGCCCAGACCCAAGAGGAGAGGGTGGTCCGCAGACACCCCGGGATGTCAGCATCCCCCGACCTGCCTTCTGGCGGCACCTC
CCGGGTGCTGTGTTGAGTCAGCAGGCATGGGGTGAGAGCCTGGTATATGCTGGGAACAGGGTGCAGGGGCCAAGCGTTCCTCCTTCAGCC
TTGACTTGGGCCATGCACCCCCTCTCCCCCAAACACAAACAAGCACTTCTCCAGTATGGTGCCAGGACAGGTGTCCCTTCAGTCCTCTGG
TTATGACCTCAAGTCCTACTTGGGCCCTGCAGCCCAGCCTGTGTTGTAACCTCTGCGTCCTCAAGACCACACCTGGAAGATTCTTCTTCC
CTTTGAAGGAGAATCATCATTGTTGCTTTATCACTTCTAAGACATTTTGTACGGCACGGACAAGTTAAACAGAATGTGCTTCCCTCCCTG
GGGTCTCACACGCTCCCACGAGAATGCCACAGGGGCCGTGCACTGGGCAGGCTTCTCTGTAGAACCCCAGGGGCTTCGGCCCAGACCACA
GCGTCTTGCCCTGAGCCTAGAGCAGGGAGTCCCGAACTTCTGCATTCACAGACCACCTCCACAATTGTTATAACCAAAGGCCTCCTGTTC
TGTTATTTCACTTAAATCAACATGCTATTTTGTTTTCACTCACTTCTGACTTTAGCCTCGTGCTGAGCCGTGTATCCATGCAGTCATGTT
CACGTGCTAGTTACGTTTTTCTTCTTACACATGAAAATAAATGCATAAGTGTTAGAAGCTCTTCCA

>27531_27531_4_ESPN-FBLIM1_ESPN_chr1_6517432_ENST00000416731_FBLIM1_chr1_16111043_ENST00000375771_length(amino acids)=257AA_BP=239
MAHSEEAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAASSPPPAPPLPLESAGPGCGQRRSSSSTGSTKSFNMMSPTGDNSELL
AEIKAGKSLKPTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSLVPVPPTTPAPGVQLDVEALIPTHDEQ
GRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEEEEARLASMPAWRRDLLRKKLEEEREQKRTAGSSCLSSPRTKAATP

--------------------------------------------------------------
>27531_27531_5_ESPN-FBLIM1_ESPN_chr1_6517432_ENST00000461727_FBLIM1_chr1_16111043_ENST00000375766_length(transcript)=2985nt_BP=938nt
ATCAGGTAACGCAGGTGTCGGGTCCTGCCGCCCCCACAGCCAGGTGCACAGCGGGGGCCACCAGCACCGTGGCAGCTGAGCTCCTGTGAC
GGCCACGACGGGCTGCGGAGGCAGGACTCCAGCCGCAAGCCCCGCGCCTTCAGCAAGCAGCCCAGCACGGGGGACTACTACCGGCAGCTG
GGCCGCTGCCCCGGCGAGACGCTGGCCGCACGCCCGGGCATGGCGCACAGCGAGGAGGCGGCGCTGCTTCCTGGGAACCATGTTCCTAAC
GGCTGCGCCGCGGACCCCAAGGCGTCCAGGGAGCTGCCACCGCCGCCCCCACCGCCGCCGCCGCCCCTGCCGGAGGCCGCGAGTTCGCCA
CCGCCGGCCCCGCCTCTGCCCCTCGAGAGCGCTGGCCCTGGCTGCGGGCAGCGCCGCTCCTCCTCGTCCACCGGCAGCACCAAGTCTTTC
AACATGATGTCCCCGACGGGCGACAACTCGGAGCTACTGGCTGAGATTAAGGCAGGCAAGAGCCTGAAGCCGACGCCCCAGAGCAAGGGG
CTGACCACAGTGTTCTCAGGCATCGGGCAGCCGGCCTTCCAGCCCGATTCGCCGCTGCCTTCTGTGTCACCTGCACTGTCACCAGTCCGG
AGCCCCACACCGCCAGCTGCGGGGTTTCAGCCGCTGCTCAATGGAAGCTTGGTTCCCGTGCCGCCCACTACTCCTGCGCCGGGAGTGCAG
CTGGACGTGGAGGCTCTCATCCCCACGCACGATGAGCAGGGCCGGCCCATCCCCGAGTGGAAGCGCCAGGTGATGGTGCGCAAGATGCAG
CTGAAGATGCAGGAGGAGGAGGAGCAGAGGCGGAAGGAGGAGGAGGAGGAGGCCCGGCTGGCCAGCATGCCCGCCTGGAGGCGGGACCTC
CTGCGGAAGAAGCTGGAAGAAGAGAGGGAGCAGAAGCGGACTGCAGGATCCTCCTGTCTGTCGAGCCCACGGACCAAGGCTGCTACCCCC
TGAACAACCATCTCTTCTGCAAGCCATGCCATGTGAAGCGGAGTGCTGCGGGGTGCTGCTGAGAGTGCCCGCTGGGCAGTGAACAGACCA
CTAGCCCCGGCTGGGGCCCTTCCCTGACTTGGTTTCCCTTCCTAACCTGCTCTTGCACACTTTCCTTCTGAGCCTCCATGGAGACCAGCC
TGCAAGCCGGCCCAGCCTGTCCAGGATACAGTGGGGCTGAGCACCCCCAGGCCTTCCACTCCTCTACCCTCTGGGCACCAGAAGGCTCCT
GGACCATGAGCTTCACCCCCAGAATTCCCTGCTGACCCTGCCCCACTTCCAGGGAAAAGCTGGGGGAGGTTGGACCCCTCTCACTGACTA
GCTGTCTGGTAGGGGTGCTAGGACCAGCCTCGCCTGTGGGGTTGAGCTGTTTGAGGACAAACTCCAAGGTCCCTTAAAAAGTGCCTTTTA
GAGGCTGGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAG
CCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTAGCAGGTGCCTGTAATCCCAGCTACTGGGG
AAAGCTGAGGCAGGAGAATTGCTTCAATCTGGAAGGCAGAGGTTGCAGTGAGATTGCACCATTGCATTCCAGCCTGGGCAACAAGAGGGA
AACTCCGTCTCAAAAAAAAAAAAGTGCCTTTTAGGCCGGATGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGC
AGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACACGGCAAAACCCCGTTTCTACTAAAAATACAAAAATTAGCTGGGTGTGG
TGGCGTGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGCATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATG
GCACCACTGCACTCCAGCCTGGGAGACACAGCGAGACTCTGTCTCCAAAAAAAAAAGTGCTTTTTGAAAATGTTGAGGTTGAAATGATGG
GAACCAACATTCTTTGGATTTAGTGGGGAGCATAATAGCAAACACCCCCTTGGTTCGCACATGTACAGGAATGGGACCCAGTTGGGGCAC
AGCCATGGACTTCCCCGCCCTGGAATGTGTGGTGCAAAGTGGGGCCAGGGCCCAGACCCAAGAGGAGAGGGTGGTCCGCAGACACCCCGG
GATGTCAGCATCCCCCGACCTGCCTTCTGGCGGCACCTCCCGGGTGCTGTGTTGAGTCAGCAGGCATGGGGTGAGAGCCTGGTATATGCT
GGGAACAGGGTGCAGGGGCCAAGCGTTCCTCCTTCAGCCTTGACTTGGGCCATGCACCCCCTCTCCCCCAAACACAAACAAGCACTTCTC
CAGTATGGTGCCAGGACAGGTGTCCCTTCAGTCCTCTGGTTATGACCTCAAGTCCTACTTGGGCCCTGCAGCCCAGCCTGTGTTGTAACC
TCTGCGTCCTCAAGACCACACCTGGAAGATTCTTCTTCCCTTTGAAGGAGAATCATCATTGTTGCTTTATCACTTCTAAGACATTTTGTA
CGGCACGGACAAGTTAAACAGAATGTGCTTCCCTCCCTGGGGTCTCACACGCTCCCACGAGAATGCCACAGGGGCCGTGCACTGGGCAGG
CTTCTCTGTAGAACCCCAGGGGCTTCGGCCCAGACCACAGCGTCTTGCCCTGAGCCTAGAGCAGGGAGTCCCGAACTTCTGCATTCACAG
ACCACCTCCACAATTGTTATAACCAAAGGCCTCCTGTTCTGTTATTTCACTTAAATCAACATGCTATTTTGTTTTCACTCACTTCTGACT
TTAGCCTCGTGCTGAGCCGTGTATCCATGCAGTCATGTTCACGTGCTAGTTACGTTTTTCTTCTTACACATGAAAATAAATGCATAAGTG
TTAGAAGCTCTTCCA

>27531_27531_5_ESPN-FBLIM1_ESPN_chr1_6517432_ENST00000461727_FBLIM1_chr1_16111043_ENST00000375766_length(amino acids)=322AA_BP=304
MPPPQPGAQRGPPAPWQLSSCDGHDGLRRQDSSRKPRAFSKQPSTGDYYRQLGRCPGETLAARPGMAHSEEAALLPGNHVPNGCAADPKA
SRELPPPPPPPPPPLPEAASSPPPAPPLPLESAGPGCGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGI
GQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSLVPVPPTTPAPGVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEE
QRRKEEEEEARLASMPAWRRDLLRKKLEEEREQKRTAGSSCLSSPRTKAATP

--------------------------------------------------------------
>27531_27531_6_ESPN-FBLIM1_ESPN_chr1_6517432_ENST00000461727_FBLIM1_chr1_16111043_ENST00000375771_length(transcript)=2985nt_BP=938nt
ATCAGGTAACGCAGGTGTCGGGTCCTGCCGCCCCCACAGCCAGGTGCACAGCGGGGGCCACCAGCACCGTGGCAGCTGAGCTCCTGTGAC
GGCCACGACGGGCTGCGGAGGCAGGACTCCAGCCGCAAGCCCCGCGCCTTCAGCAAGCAGCCCAGCACGGGGGACTACTACCGGCAGCTG
GGCCGCTGCCCCGGCGAGACGCTGGCCGCACGCCCGGGCATGGCGCACAGCGAGGAGGCGGCGCTGCTTCCTGGGAACCATGTTCCTAAC
GGCTGCGCCGCGGACCCCAAGGCGTCCAGGGAGCTGCCACCGCCGCCCCCACCGCCGCCGCCGCCCCTGCCGGAGGCCGCGAGTTCGCCA
CCGCCGGCCCCGCCTCTGCCCCTCGAGAGCGCTGGCCCTGGCTGCGGGCAGCGCCGCTCCTCCTCGTCCACCGGCAGCACCAAGTCTTTC
AACATGATGTCCCCGACGGGCGACAACTCGGAGCTACTGGCTGAGATTAAGGCAGGCAAGAGCCTGAAGCCGACGCCCCAGAGCAAGGGG
CTGACCACAGTGTTCTCAGGCATCGGGCAGCCGGCCTTCCAGCCCGATTCGCCGCTGCCTTCTGTGTCACCTGCACTGTCACCAGTCCGG
AGCCCCACACCGCCAGCTGCGGGGTTTCAGCCGCTGCTCAATGGAAGCTTGGTTCCCGTGCCGCCCACTACTCCTGCGCCGGGAGTGCAG
CTGGACGTGGAGGCTCTCATCCCCACGCACGATGAGCAGGGCCGGCCCATCCCCGAGTGGAAGCGCCAGGTGATGGTGCGCAAGATGCAG
CTGAAGATGCAGGAGGAGGAGGAGCAGAGGCGGAAGGAGGAGGAGGAGGAGGCCCGGCTGGCCAGCATGCCCGCCTGGAGGCGGGACCTC
CTGCGGAAGAAGCTGGAAGAAGAGAGGGAGCAGAAGCGGACTGCAGGATCCTCCTGTCTGTCGAGCCCACGGACCAAGGCTGCTACCCCC
TGAACAACCATCTCTTCTGCAAGCCATGCCATGTGAAGCGGAGTGCTGCGGGGTGCTGCTGAGAGTGCCCGCTGGGCAGTGAACAGACCA
CTAGCCCCGGCTGGGGCCCTTCCCTGACTTGGTTTCCCTTCCTAACCTGCTCTTGCACACTTTCCTTCTGAGCCTCCATGGAGACCAGCC
TGCAAGCCGGCCCAGCCTGTCCAGGATACAGTGGGGCTGAGCACCCCCAGGCCTTCCACTCCTCTACCCTCTGGGCACCAGAAGGCTCCT
GGACCATGAGCTTCACCCCCAGAATTCCCTGCTGACCCTGCCCCACTTCCAGGGAAAAGCTGGGGGAGGTTGGACCCCTCTCACTGACTA
GCTGTCTGGTAGGGGTGCTAGGACCAGCCTCGCCTGTGGGGTTGAGCTGTTTGAGGACAAACTCCAAGGTCCCTTAAAAAGTGCCTTTTA
GAGGCTGGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAG
CCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTAGCAGGTGCCTGTAATCCCAGCTACTGGGG
AAAGCTGAGGCAGGAGAATTGCTTCAATCTGGAAGGCAGAGGTTGCAGTGAGATTGCACCATTGCATTCCAGCCTGGGCAACAAGAGGGA
AACTCCGTCTCAAAAAAAAAAAAGTGCCTTTTAGGCCGGATGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGC
AGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACACGGCAAAACCCCGTTTCTACTAAAAATACAAAAATTAGCTGGGTGTGG
TGGCGTGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGCATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATG
GCACCACTGCACTCCAGCCTGGGAGACACAGCGAGACTCTGTCTCCAAAAAAAAAAGTGCTTTTTGAAAATGTTGAGGTTGAAATGATGG
GAACCAACATTCTTTGGATTTAGTGGGGAGCATAATAGCAAACACCCCCTTGGTTCGCACATGTACAGGAATGGGACCCAGTTGGGGCAC
AGCCATGGACTTCCCCGCCCTGGAATGTGTGGTGCAAAGTGGGGCCAGGGCCCAGACCCAAGAGGAGAGGGTGGTCCGCAGACACCCCGG
GATGTCAGCATCCCCCGACCTGCCTTCTGGCGGCACCTCCCGGGTGCTGTGTTGAGTCAGCAGGCATGGGGTGAGAGCCTGGTATATGCT
GGGAACAGGGTGCAGGGGCCAAGCGTTCCTCCTTCAGCCTTGACTTGGGCCATGCACCCCCTCTCCCCCAAACACAAACAAGCACTTCTC
CAGTATGGTGCCAGGACAGGTGTCCCTTCAGTCCTCTGGTTATGACCTCAAGTCCTACTTGGGCCCTGCAGCCCAGCCTGTGTTGTAACC
TCTGCGTCCTCAAGACCACACCTGGAAGATTCTTCTTCCCTTTGAAGGAGAATCATCATTGTTGCTTTATCACTTCTAAGACATTTTGTA
CGGCACGGACAAGTTAAACAGAATGTGCTTCCCTCCCTGGGGTCTCACACGCTCCCACGAGAATGCCACAGGGGCCGTGCACTGGGCAGG
CTTCTCTGTAGAACCCCAGGGGCTTCGGCCCAGACCACAGCGTCTTGCCCTGAGCCTAGAGCAGGGAGTCCCGAACTTCTGCATTCACAG
ACCACCTCCACAATTGTTATAACCAAAGGCCTCCTGTTCTGTTATTTCACTTAAATCAACATGCTATTTTGTTTTCACTCACTTCTGACT
TTAGCCTCGTGCTGAGCCGTGTATCCATGCAGTCATGTTCACGTGCTAGTTACGTTTTTCTTCTTACACATGAAAATAAATGCATAAGTG
TTAGAAGCTCTTCCA

>27531_27531_6_ESPN-FBLIM1_ESPN_chr1_6517432_ENST00000461727_FBLIM1_chr1_16111043_ENST00000375771_length(amino acids)=322AA_BP=304
MPPPQPGAQRGPPAPWQLSSCDGHDGLRRQDSSRKPRAFSKQPSTGDYYRQLGRCPGETLAARPGMAHSEEAALLPGNHVPNGCAADPKA
SRELPPPPPPPPPPLPEAASSPPPAPPLPLESAGPGCGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGI
GQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSLVPVPPTTPAPGVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEE
QRRKEEEEEARLASMPAWRRDLLRKKLEEEREQKRTAGSSCLSSPRTKAATP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ESPN-FBLIM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ESPN-FBLIM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ESPN-FBLIM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneESPNC3711374Nonsyndromic Deafness11CLINGEN
HgeneESPNC1837007DEAFNESS, AUTOSOMAL RECESSIVE 36, WITH OR WITHOUT VESTIBULAR INVOLVEMENT3CTD_human;UNIPROT
HgeneESPNC0011052Prelingual Deafness2CTD_human
HgeneESPNC0011053Deafness2CTD_human
HgeneESPNC0086395Hearing Loss, Extreme2CTD_human
HgeneESPNC0581883Complete Hearing Loss2CTD_human
HgeneESPNC0751068Deafness, Acquired2CTD_human
HgeneESPNC3665473Bilateral Deafness2CTD_human
HgeneESPNC4082305Deaf Mutism2CTD_human
HgeneESPNC0042594Vestibular Diseases1CTD_human
TgeneC1864997Majeed syndrome1GENOMICS_ENGLAND