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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TM2D2-GOT1L1 (FusionGDB2 ID:HG83877TG137362)

Fusion Gene Summary for TM2D2-GOT1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: TM2D2-GOT1L1
Fusion gene ID: hg83877tg137362
HgeneTgene
Gene symbol

TM2D2

GOT1L1

Gene ID

83877

137362

Gene nameTM2 domain containing 2glutamic-oxaloacetic transaminase 1 like 1
SynonymsBLP1-
Cytomap('TM2D2')('GOT1L1')

8p11.22

8p11.23

Type of geneprotein-codingprotein-coding
DescriptionTM2 domain-containing protein 2BBP-like protein 1beta-amyloid-binding protein-like protein 1putative aspartate aminotransferase, cytoplasmic 2glutamate oxaloacetate transaminase 1-like protein 1transaminase A-like protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000397070, ENST00000412303, 
ENST00000456397, ENST00000456845, 
ENST00000522434, 
Fusion gene scores* DoF score4 X 6 X 3=723 X 4 X 2=24
# samples 62
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/24*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TM2D2 [Title/Abstract] AND GOT1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTM2D2(38851064)-GOT1L1(37792004), # samples:1
TM2D2(38851064)-GOT1L1(37792733), # samples:1
Anticipated loss of major functional domain due to fusion event.TM2D2-GOT1L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TM2D2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GOT1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-AAMZ-01ATM2D2chr8

38851064

-GOT1L1chr8

37792004

-
ChimerDB4BLCATCGA-XF-AAMZ-01ATM2D2chr8

38851064

-GOT1L1chr8

37792733

-


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Fusion Gene ORF analysis for TM2D2-GOT1L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000397070ENST00000518826TM2D2chr8

38851064

-GOT1L1chr8

37792004

-
5CDS-intronENST00000412303ENST00000518826TM2D2chr8

38851064

-GOT1L1chr8

37792004

-
5CDS-intronENST00000456397ENST00000518826TM2D2chr8

38851064

-GOT1L1chr8

37792004

-
5CDS-intronENST00000456845ENST00000518826TM2D2chr8

38851064

-GOT1L1chr8

37792004

-
5UTR-3CDSENST00000522434ENST00000307599TM2D2chr8

38851064

-GOT1L1chr8

37792004

-
5UTR-3CDSENST00000522434ENST00000307599TM2D2chr8

38851064

-GOT1L1chr8

37792733

-
5UTR-3CDSENST00000522434ENST00000518826TM2D2chr8

38851064

-GOT1L1chr8

37792733

-
5UTR-intronENST00000522434ENST00000518826TM2D2chr8

38851064

-GOT1L1chr8

37792004

-
Frame-shiftENST00000397070ENST00000307599TM2D2chr8

38851064

-GOT1L1chr8

37792733

-
Frame-shiftENST00000397070ENST00000518826TM2D2chr8

38851064

-GOT1L1chr8

37792733

-
Frame-shiftENST00000412303ENST00000307599TM2D2chr8

38851064

-GOT1L1chr8

37792004

-
Frame-shiftENST00000412303ENST00000518826TM2D2chr8

38851064

-GOT1L1chr8

37792733

-
Frame-shiftENST00000456397ENST00000307599TM2D2chr8

38851064

-GOT1L1chr8

37792004

-
Frame-shiftENST00000456397ENST00000518826TM2D2chr8

38851064

-GOT1L1chr8

37792733

-
Frame-shiftENST00000456845ENST00000307599TM2D2chr8

38851064

-GOT1L1chr8

37792004

-
Frame-shiftENST00000456845ENST00000307599TM2D2chr8

38851064

-GOT1L1chr8

37792733

-
In-frameENST00000397070ENST00000307599TM2D2chr8

38851064

-GOT1L1chr8

37792004

-
In-frameENST00000412303ENST00000307599TM2D2chr8

38851064

-GOT1L1chr8

37792733

-
In-frameENST00000456397ENST00000307599TM2D2chr8

38851064

-GOT1L1chr8

37792733

-
In-frameENST00000456845ENST00000518826TM2D2chr8

38851064

-GOT1L1chr8

37792733

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397070TM2D2chr838851064-ENST00000307599GOT1L1chr837792004-1096890585953122
ENST00000456845TM2D2chr838851064-ENST00000518826GOT1L1chr837792733-784557252770172
ENST00000412303TM2D2chr838851064-ENST00000307599GOT1L1chr837792733-10466973921033213
ENST00000456397TM2D2chr838851064-ENST00000307599GOT1L1chr837792733-87452594861255

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397070ENST00000307599TM2D2chr838851064-GOT1L1chr837792004-0.0148602630.9851398
ENST00000456845ENST00000518826TM2D2chr838851064-GOT1L1chr837792733-0.0050068670.99499315
ENST00000412303ENST00000307599TM2D2chr838851064-GOT1L1chr837792733-0.0017665310.99823344
ENST00000456397ENST00000307599TM2D2chr838851064-GOT1L1chr837792733-0.004299680.99570036

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Fusion Genomic Features for TM2D2-GOT1L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for TM2D2-GOT1L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38851064/chr8:37792004)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTM2D2chr8:38851064chr8:37792004ENST00000397070-34145_165100172.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792004ENST00000397070-34183_203100172.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792004ENST00000412303-34145_165100172.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792004ENST00000412303-34183_203100172.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792004ENST00000456397-34145_165143215.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792004ENST00000456397-34183_203143215.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792004ENST00000456845-34145_165100172.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792004ENST00000456845-34183_203100172.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792733ENST00000397070-34145_165100172.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792733ENST00000397070-34183_203100172.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792733ENST00000412303-34145_165100172.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792733ENST00000412303-34183_203100172.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792733ENST00000456397-34145_165143215.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792733ENST00000456397-34183_203143215.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792733ENST00000456845-34145_165100172.0TransmembraneHelical
HgeneTM2D2chr8:38851064chr8:37792733ENST00000456845-34183_203100172.0TransmembraneHelical


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Fusion Gene Sequence for TM2D2-GOT1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91212_91212_1_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000397070_GOT1L1_chr8_37792004_ENST00000307599_length(transcript)=1096nt_BP=890nt
AGTTCTTGGGTCTGTGCTGCTGGCCTGGGGTTGTGGTTGAGGCCGGGTCTCCGCTCCTGTGCCCGGGAAGATGGTGCTAGGTGGTTGCCC
GGTTAGTTACTTACTTCTGTGCGGCCAGGCGGCTTTGCTGCTGGGGAATTTACTTCTGCTGCATTGTGTGTCTCGGAGCCACTCGCAAAA
TGCGACCGCTGAGCCTGAGCTCACATCCGCTGGCGCCGCCCAGCCGGAGGGCCCCGGGGGTGCTGCGAGCTGGGAATATGGCGACCCCCA
CTCTCCGGTCATCCTCTGCTCTTACCTAATCACGCCATTTTTTAACATCTCTTTTTGATCAAACAAGAAAAGGCATTTGGGAAATGCAAA
GAGGACTGAGAATACTTTGGCTTAAATTTTGCCCCCAGAATCTTGTTGTTTGCCTACTGAAGAGATGAAACCATGGCAGAAGTAGAATCC
TTATAGAAACAGGACCAGAAACACCTCCCTTCTCCAACAAAAGGTTCATTTTGGTGGCTGTCCGTTTGACCTGCTGTGCTTCAGTTTAAT
TGGCTTGGAAAGGGGTCAGCAGGGTGAAACCGAACCCCAGAAAACTTGATGAAGAAATGTCTTTTGCCCGTTTTGATTACGTGCATGCAA
ACAGCGATTTGCAAAGACCGTATGATGATGATCATGATCTTACTGGTGAATTACAGACCTGATGAATTTATAGAATGTGAAGACCCAGTG
GATCATGTTGGAAATGCAACTGCATCCCAGGAACTTGGTTATGGTTGTCTCAAGTTCGGCGGTCAGGCCTACAGCGACGTGGAACACACT
TCAGTCCAGTGCCATGCCTTAGATGGAATTGAGTGTGCCAGTCCTAGGACCTTTCTACGAGAAAATAAACCTTGTATAAACCCAGCAGGT
GGAATACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATAAATTACAT
CACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGTGTCTTCCAAAGGAAAAAAAAACACTGATTGGAATAAAACT
TTAGTCTTTGCAAAAA

>91212_91212_1_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000397070_GOT1L1_chr8_37792004_ENST00000307599_length(amino acids)=122AA_BP=102
MMKKCLLPVLITCMQTAICKDRMMMIMILLVNYRPDEFIECEDPVDHVGNATASQELGYGCLKFGGQAYSDVEHTSVQCHALDGIECASP
RTFLRENKPCINPAGGIPGQEEAHLYPQERSD

--------------------------------------------------------------
>91212_91212_2_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000412303_GOT1L1_chr8_37792733_ENST00000307599_length(transcript)=1046nt_BP=697nt
GGCCTGACCACGCAGTTCTTGGGTCTGTGCTGCTGGCCTGGGGTTGTGGTTGAGGCCGGGTCTCCGCTCCTGTGCCCGGGAAGATGGTGC
TAGGTGGTTGCCCGAATCACGCCATTTTTTAACATCTCTTTTTGATCAAACAAGAAAAGGCATTTGGGAAATGCAAAGAGGACTGAGAAT
ACTTTGGCTTAAATTTTGCCCCCAGAATCTTGTTGTTTGCCTACTGAAGAGATGAAACCATGGCAGAAGTAGAATCCTTATAGAAACAGG
ACCAGAAACACCTCCCTTCTCCAACAAAAGGTTCATTTTGGTGGCTGTCCGTTTGACCTGCTGTGCTTCAGTTTAATTGGCTTGGAAAGG
GGTCAGCAGGGTGAAACCGAACCCCAGAAAACTTGATGAAGAAATGTCTTTTGCCCGTTTTGATTACGTGCATGCAAACAGCGATTTGCA
AAGACCGTATGATGATGATCATGATCTTACTGGTGAATTACAGACCTGATGAATTTATAGAATGTGAAGACCCAGTGGATCATGTTGGAA
ATGCAACTGCATCCCAGGAACTTGGTTATGGTTGTCTCAAGTTCGGCGGTCAGGCCTACAGCGACGTGGAACACACTTCAGTCCAGTGCC
ATGCCTTAGATGGAATTGAGTGTGCCAGTCCTAGGACCTTTCTACGAGAAAATAAACCTTGTATAAAGAAGCAGAGTCTAAAAGAAGTTG
TAGAGAACATCATGCTAACCAAGGAAAAAGTGAAGGAGAAACTCCAGCTCCTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGA
GTGGGACCCACGGCTATCTTGGACTCAACTCCCAGCAGGTGGAATACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGA
TTAACTTCAGCTGTATCAATGCCAACAACATAAATTACATCACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGT
GTCTTCCAAAGGAAAAAAAAACACTGATTGGAATAAAACTTTAGTCTTTGCAAAAA

>91212_91212_2_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000412303_GOT1L1_chr8_37792733_ENST00000307599_length(amino acids)=213AA_BP=102
MMKKCLLPVLITCMQTAICKDRMMMIMILLVNYRPDEFIECEDPVDHVGNATASQELGYGCLKFGGQAYSDVEHTSVQCHALDGIECASP
RTFLRENKPCIKKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITEQSGTHGYLGLNSQQVEYLVRKKHIYIPKNGQINFSCINANNI
NYITEGINEAVLLTESSEMCLPKEKKTLIGIKL

--------------------------------------------------------------
>91212_91212_3_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000456397_GOT1L1_chr8_37792733_ENST00000307599_length(transcript)=874nt_BP=525nt
CTACGCGGAAAGGCCTGACCACGCAGTTCTTGGGTCTGTGCTGCTGGCCTGGGGTTGTGGTTGAGGCCGGGTCTCCGCTCCTGTGCCCGG
GAAGATGGTGCTAGGTGGTTGCCCGGTTAGTTACTTACTTCTGTGCGGCCAGGCGGCTTTGCTGCTGGGGAATTTACTTCTGCTGCATTG
TGTGTCTCGGAGCCACTCGCAAAATGCGACCGCTGAGCCTGAGCTCACATCCGCTGGCGCCGCCCAGCCGGAGGGCCCCGGGGGTGCTGC
GAGCTGGGAATATGGCGACCCCCACTCTCCGGTCATCCTCTGCTCTTACCTACCTGATGAATTTATAGAATGTGAAGACCCAGTGGATCA
TGTTGGAAATGCAACTGCATCCCAGGAACTTGGTTATGGTTGTCTCAAGTTCGGCGGTCAGGCCTACAGCGACGTGGAACACACTTCAGT
CCAGTGCCATGCCTTAGATGGAATTGAGTGTGCCAGTCCTAGGACCTTTCTACGAGAAAATAAACCTTGTATAAAGAAGCAGAGTCTAAA
AGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTGAAGGAGAAACTCCAGCTCCTGGGAACCCCTGGGTCCTGGGGTCACATCAC
CGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTCCCAGCAGGTGGAATACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAA
CGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATAAATTACATCACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTC
AGAGATGTGTCTTCCAAAGGAAAAAAAAACACTGATTGGAATAAAACTTTAGTCTTTGCAAAAA

>91212_91212_3_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000456397_GOT1L1_chr8_37792733_ENST00000307599_length(amino acids)=255AA_BP=144
MVLGGCPVSYLLLCGQAALLLGNLLLLHCVSRSHSQNATAEPELTSAGAAQPEGPGGAASWEYGDPHSPVILCSYLPDEFIECEDPVDHV
GNATASQELGYGCLKFGGQAYSDVEHTSVQCHALDGIECASPRTFLRENKPCIKKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITE
QSGTHGYLGLNSQQVEYLVRKKHIYIPKNGQINFSCINANNINYITEGINEAVLLTESSEMCLPKEKKTLIGIKL

--------------------------------------------------------------
>91212_91212_4_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000456845_GOT1L1_chr8_37792733_ENST00000518826_length(transcript)=784nt_BP=557nt
GGGGTTGTGGTTGAGGCCGGGTCTCCGCTCCTGTGCCCGGGAAGATGGTGCTAGGTGGTTGCCCGAATCTTGTTGTTTGCCTACTGAAGA
GATGAAACCATGGCAGAAGTAGAATCCTTATAGAAACAGGACCAGAAACACCTCCCTTCTCCAACAAAAGGTTCATTTTGGTGGCTGTCC
GTTTGACCTGCTGTGCTTCAGTTTAATTGGCTTGGAAAGGGGTCAGCAGGGTGAAACCGAACCCCAGAAAACTTGATGAAGAAATGTCTT
TTGCCCGTTTTGATTACGTGCATGCAAACAGCGATTTGCAAAGACCGTATGATGATGATCATGATCTTACTGGTGAATTACAGACCTGAT
GAATTTATAGAATGTGAAGACCCAGTGGATCATGTTGGAAATGCAACTGCATCCCAGGAACTTGGTTATGGTTGTCTCAAGTTCGGCGGT
CAGGCCTACAGCGACGTGGAACACACTTCAGTCCAGTGCCATGCCTTAGATGGAATTGAGTGTGCCAGTCCTAGGACCTTTCTACGAGAA
AATAAACCTTGTATAAAGAAGCAGAGTCTAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTGAAGGAGAAACTCCAGCTC
CTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTGTAAGGGTCTAGGGGGCTGG
TGTCCCCCCTTTCTGACCTTTGGCCTGTATTTGAGCATTAAACTTCACTGACTAGGTGACCAGT

>91212_91212_4_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000456845_GOT1L1_chr8_37792733_ENST00000518826_length(amino acids)=172AA_BP=102
MMKKCLLPVLITCMQTAICKDRMMMIMILLVNYRPDEFIECEDPVDHVGNATASQELGYGCLKFGGQAYSDVEHTSVQCHALDGIECASP
RTFLRENKPCIKKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITEQSGTHGYLGLNCKGLGGWCPPFLTFGLYLSIKLH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TM2D2-GOT1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TM2D2-GOT1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TM2D2-GOT1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource