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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KATNAL1-CUL4A (FusionGDB2 ID:HG84056TG8451) |
Fusion Gene Summary for KATNAL1-CUL4A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KATNAL1-CUL4A | Fusion gene ID: hg84056tg8451 | Hgene | Tgene | Gene symbol | KATNAL1 | CUL4A | Gene ID | 84056 | 8451 |
| Gene name | katanin catalytic subunit A1 like 1 | cullin 4A | |
| Synonyms | - | - | |
| Cytomap | ('KATNAL1')('CUL4A') 13q12.3 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | katanin p60 ATPase-containing subunit A-like 1katanin catalytic subunit A like 1katanin p60 subunit A like 1p60 katanin-like 1 | cullin-4ACUL-4A | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | Q9BW62 | Q13619 | |
| Ensembl transtripts involved in fusion gene | ENST00000380615, ENST00000380617, | ||
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 15 X 13 X 9=1755 |
| # samples | 3 | 20 | |
| ** MAII score | log2(3/48*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1755*10)=-3.1333991254172 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KATNAL1 [Title/Abstract] AND CUL4A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KATNAL1(30857753)-CUL4A(113907396), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | KATNAL1-CUL4A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. KATNAL1-CUL4A seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KATNAL1 | GO:0051013 | microtubule severing | 26929214 |
| Tgene | CUL4A | GO:0016567 | protein ubiquitination | 26431207 |
| Fusion gene breakpoints across KATNAL1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CUL4A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-D3-A5GR-06A | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + |
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Fusion Gene ORF analysis for KATNAL1-CUL4A |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000380615 | ENST00000463426 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + |
| 5CDS-intron | ENST00000380617 | ENST00000463426 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + |
| Frame-shift | ENST00000380615 | ENST00000326335 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + |
| Frame-shift | ENST00000380615 | ENST00000375440 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + |
| Frame-shift | ENST00000380615 | ENST00000375441 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + |
| Frame-shift | ENST00000380615 | ENST00000451881 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + |
| In-frame | ENST00000380617 | ENST00000326335 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + |
| In-frame | ENST00000380617 | ENST00000375440 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + |
| In-frame | ENST00000380617 | ENST00000375441 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + |
| In-frame | ENST00000380617 | ENST00000451881 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000380617 | KATNAL1 | chr13 | 30857753 | - | ENST00000375441 | CUL4A | chr13 | 113907396 | + | 905 | 263 | 101 | 904 | 268 |
| ENST00000380617 | KATNAL1 | chr13 | 30857753 | - | ENST00000451881 | CUL4A | chr13 | 113907396 | + | 2400 | 263 | 101 | 904 | 267 |
| ENST00000380617 | KATNAL1 | chr13 | 30857753 | - | ENST00000326335 | CUL4A | chr13 | 113907396 | + | 2408 | 263 | 101 | 904 | 267 |
| ENST00000380617 | KATNAL1 | chr13 | 30857753 | - | ENST00000375440 | CUL4A | chr13 | 113907396 | + | 905 | 263 | 101 | 904 | 268 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000380617 | ENST00000375441 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + | 0.002729658 | 0.9972703 |
| ENST00000380617 | ENST00000451881 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + | 0.00053935 | 0.99946064 |
| ENST00000380617 | ENST00000326335 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + | 0.000534279 | 0.99946576 |
| ENST00000380617 | ENST00000375440 | KATNAL1 | chr13 | 30857753 | - | CUL4A | chr13 | 113907396 | + | 0.002729658 | 0.9972703 |
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Fusion Genomic Features for KATNAL1-CUL4A |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| KATNAL1 | chr13 | 30857752 | - | CUL4A | chr13 | 113907395 | + | 0.001698692 | 0.99830127 |
| KATNAL1 | chr13 | 30857752 | - | CUL4A | chr13 | 113907395 | + | 0.001698692 | 0.99830127 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KATNAL1-CUL4A |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:30857753/chr13:113907396) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KATNAL1 | CUL4A |
| FUNCTION: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (PubMed:26929214). {ECO:0000250|UniProtKB:Q8K0T4, ECO:0000269|PubMed:26929214}. | FUNCTION: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). With CUL4B, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269|PubMed:14578910, ECO:0000269|PubMed:14609952, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15548678, ECO:0000269|PubMed:16537899, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:24209620, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:26711351}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KATNAL1 | chr13:30857753 | chr13:113907396 | ENST00000380615 | - | 2 | 11 | 248_255 | 54 | 491.0 | Nucleotide binding | ATP |
| Hgene | KATNAL1 | chr13:30857753 | chr13:113907396 | ENST00000380617 | - | 2 | 11 | 248_255 | 54 | 491.0 | Nucleotide binding | ATP |
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Fusion Gene Sequence for KATNAL1-CUL4A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >41261_41261_1_KATNAL1-CUL4A_KATNAL1_chr13_30857753_ENST00000380617_CUL4A_chr13_113907396_ENST00000326335_length(transcript)=2408nt_BP=263nt GACAGAAAAAAAAATCTCTCTTTGTCTTGAGGGGGCTGTTGAGTGGTCGCGGACCTGGGCTCTGTGCGTTGGGAAAGGGAAGTGGAGGTC TCTGAAAGAAGATGAATTTGGCTGAGATTTGTGATAATGCAAAGAAAGGAAGAGAATATGCCCTTCTTGGAAATTACGACTCATCAATGG TATATTACCAGGGGGTGATGCAGCAGATTCAGAGACATTGCCAGTCAGTCAGAGATCCAGCTATCAAAGGCAAATGGCAACAGATGATTA AACTTCAGGAAGTATTTAAGGCATTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAA AAGCGGAGTTTAAAGAAGGGAAGAAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCA GCTTTGAGGAGATAAAAATGGCCACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGC TGATTAAAAGTCCCAAAGGAAAGGAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGA TCAATCAAATTCAGATGAAGGAAACTGTTGAGGAACAGGTTAGCACCACTGAGAGAGTGTTTCAGGATAGACAATATCAGATTGATGCTG CTATCGTCAGAATAATGAAGATGAGAAAGACTCTTGGTCATAATCTTCTAGTTTCTGAATTATATAATCAGCTGAAATTTCCAGTAAAGC CTGGAGATTTGAAAAAGAGAATTGAATCTCTGATAGACAGAGACTATATGGAGAGAGACAAAGACAATCCGAATCAGTACCACTACGTGG CCTGACGCATCTGCAGACGGTTCCCCTTCATGAAACACTAGAATGTACCCTCAGAGCAGGAAGCACACCTGTGCCATTTCTGGGACTCTG ATTGATCCAGCTGTGGACATTGGAAGGCGAAGGAAGGGAGGTGGCTCCTGGGTCATCTTTCACAAGGCTCAAGACTTCAACCTGCAGATG TATCTTTTTCCCTCCAGTTTTTCCTCTAGTTCTTTTAGGCATTTAAATTGTTTCTGTTACTCTGTGCAAAATAACTTTGAGATTGGACAA GAAGATGTTACTAAAGAGAAGTTCCTTTAAAAGGTCTTGTTCTTGTGTCAAAAAGCTGCAAGTTTGGTTTGTTCTCGTGTGTGATCATGA GTGCACAATGAAGAAGACCCTAGATGCTGCATTTTTTAGCTCTGAAGATTCCTTAGGTATCCCTGAAGACAGCTCGCTCAGATGATCAGC ATTTAGAGTGAAAACAAGGGCCCTTCATGGGTGAACATTAGAAAGAGCCAGGGTTCAAAGCTGGCGAATGGATGACGCACCCTAGCCACT GGCCCCTCTCTGTTTCATGTATTTCCAAAAGTTGTAAACTTTGATGGCTGATTTTTCGTAAGTCAGGTTTCTAAGTGAGCTCCCTGAGGT GCCAAGGCCATGGTGTCCGCCCTGCTGCGTCTGTTCGTCAGCTGAGTTCCTTGTGAATCTCTGTTTTAGGGTTTGGGGCTAGTGTGTTTG TGTTTCCATTCTAAGATTGAGTCTGGCAGTCCCTGTTTTTTTGCATTGGGGTAACTGCTCTTTGATTTTTTTTAATTGCAGTATTTGTGT GATTGCAATAATAAAGTTTGGTTTGGTTTTTACAGTCATGCGCAGGGACGATCCTTGTTCTCTGCTGTAAACTGTAAAAAGTTTATGGAG ACTTAAAGTCTTGATGTTGTGAAGCAGAGGTTATTTTGTGGAAAGATTAAAAGGATTTTGTTGGTACCTGGTTTTGTGTTGTGTATATAT ACATGAGGTTGAACAGTGAAAGGAAAGTTCAGTAGTGATGTTAGAAGGGTAACTATGACAAAGATACTTTTGAGATAACATTTAAAAGTA CTTTATATTTTACATAATAGCATGTTTCATTTTGATTAAAAGCTACCAAAGGAATTTTGATCATGGCATAAGTGTTTAAAGCAATATTTT CTGGAATATACCAAGTTTATATAATTTGATTTTGTGCTAAATTATTAAGAGTCTCTTTTTGAAACATGCGGGTTTGAAATATGACACCTT GTGGGTTTCCATATTAAAATCCTCACTCTTTAATTGTCATTTCTATCTTTGAAAATTTTCATTTATGAGTTCCATGATATGTGGTCTAAG AAAGACCAAACAGATTTCTATTTTTTTTTTCTTATAAGTTCGTTGTGTCTAGAGATTGTTAATATTGTAATTTAATGTAGACTTACTTTG AATAAAATTAGTTTAATTGGCCTTAAAATTACATTAATAAAACTTTGTGATATGCAAATGACACATTC >41261_41261_1_KATNAL1-CUL4A_KATNAL1_chr13_30857753_ENST00000380617_CUL4A_chr13_113907396_ENST00000326335_length(amino acids)=267AA_BP=53 MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEF KEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQI QMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA -------------------------------------------------------------- >41261_41261_2_KATNAL1-CUL4A_KATNAL1_chr13_30857753_ENST00000380617_CUL4A_chr13_113907396_ENST00000375440_length(transcript)=905nt_BP=263nt GACAGAAAAAAAAATCTCTCTTTGTCTTGAGGGGGCTGTTGAGTGGTCGCGGACCTGGGCTCTGTGCGTTGGGAAAGGGAAGTGGAGGTC TCTGAAAGAAGATGAATTTGGCTGAGATTTGTGATAATGCAAAGAAAGGAAGAGAATATGCCCTTCTTGGAAATTACGACTCATCAATGG TATATTACCAGGGGGTGATGCAGCAGATTCAGAGACATTGCCAGTCAGTCAGAGATCCAGCTATCAAAGGCAAATGGCAACAGATGATTA AACTTCAGGAAGTATTTAAGGCATTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAA AAGCGGAGTTTAAAGAAGGGAAGAAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCA GCTTTGAGGAGATAAAAATGGCCACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGC TGATTAAAAGTCCCAAAGGAAAGGAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGA TCAATCAAATTCAGATGAAGGAAACTGTTGAGGAACAGGTTAGCACCACTGAGAGAGTGTTTCAGGATAGACAATATCAGATTGATGCTG CTATCGTCAGAATAATGAAGATGAGAAAGACTCTTGGTCATAATCTTCTAGTTTCTGAATTATATAATCAGCTGAAATTTCCAGTAAAGC CTGGAGATTTGAAAAAGAGAATTGAATCTCTGATAGACAGAGACTATATGGAGAGAGACAAAGACAATCCGAATCAGTACCACTACGTGG CCTGA >41261_41261_2_KATNAL1-CUL4A_KATNAL1_chr13_30857753_ENST00000380617_CUL4A_chr13_113907396_ENST00000375440_length(amino acids)=268AA_BP=53 MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEF KEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQI QMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVAX -------------------------------------------------------------- >41261_41261_3_KATNAL1-CUL4A_KATNAL1_chr13_30857753_ENST00000380617_CUL4A_chr13_113907396_ENST00000375441_length(transcript)=905nt_BP=263nt GACAGAAAAAAAAATCTCTCTTTGTCTTGAGGGGGCTGTTGAGTGGTCGCGGACCTGGGCTCTGTGCGTTGGGAAAGGGAAGTGGAGGTC TCTGAAAGAAGATGAATTTGGCTGAGATTTGTGATAATGCAAAGAAAGGAAGAGAATATGCCCTTCTTGGAAATTACGACTCATCAATGG TATATTACCAGGGGGTGATGCAGCAGATTCAGAGACATTGCCAGTCAGTCAGAGATCCAGCTATCAAAGGCAAATGGCAACAGATGATTA AACTTCAGGAAGTATTTAAGGCATTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAA AAGCGGAGTTTAAAGAAGGGAAGAAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCA GCTTTGAGGAGATAAAAATGGCCACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGC TGATTAAAAGTCCCAAAGGAAAGGAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGA TCAATCAAATTCAGATGAAGGAAACTGTTGAGGAACAGGTTAGCACCACTGAGAGAGTGTTTCAGGATAGACAATATCAGATTGATGCTG CTATCGTCAGAATAATGAAGATGAGAAAGACTCTTGGTCATAATCTTCTAGTTTCTGAATTATATAATCAGCTGAAATTTCCAGTAAAGC CTGGAGATTTGAAAAAGAGAATTGAATCTCTGATAGACAGAGACTATATGGAGAGAGACAAAGACAATCCGAATCAGTACCACTACGTGG CCTGA >41261_41261_3_KATNAL1-CUL4A_KATNAL1_chr13_30857753_ENST00000380617_CUL4A_chr13_113907396_ENST00000375441_length(amino acids)=268AA_BP=53 MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEF KEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQI QMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVAX -------------------------------------------------------------- >41261_41261_4_KATNAL1-CUL4A_KATNAL1_chr13_30857753_ENST00000380617_CUL4A_chr13_113907396_ENST00000451881_length(transcript)=2400nt_BP=263nt GACAGAAAAAAAAATCTCTCTTTGTCTTGAGGGGGCTGTTGAGTGGTCGCGGACCTGGGCTCTGTGCGTTGGGAAAGGGAAGTGGAGGTC TCTGAAAGAAGATGAATTTGGCTGAGATTTGTGATAATGCAAAGAAAGGAAGAGAATATGCCCTTCTTGGAAATTACGACTCATCAATGG TATATTACCAGGGGGTGATGCAGCAGATTCAGAGACATTGCCAGTCAGTCAGAGATCCAGCTATCAAAGGCAAATGGCAACAGATGATTA AACTTCAGGAAGTATTTAAGGCATTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAA AAGCGGAGTTTAAAGAAGGGAAGAAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCA GCTTTGAGGAGATAAAAATGGCCACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGC TGATTAAAAGTCCCAAAGGAAAGGAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGA TCAATCAAATTCAGATGAAGGAAACTGTTGAGGAACAGGTTAGCACCACTGAGAGAGTGTTTCAGGATAGACAATATCAGATTGATGCTG CTATCGTCAGAATAATGAAGATGAGAAAGACTCTTGGTCATAATCTTCTAGTTTCTGAATTATATAATCAGCTGAAATTTCCAGTAAAGC CTGGAGATTTGAAAAAGAGAATTGAATCTCTGATAGACAGAGACTATATGGAGAGAGACAAAGACAATCCGAATCAGTACCACTACGTGG CCTGACGCATCTGCAGACGGTTCCCCTTCATGAAACACTAGAATGTACCCTCAGAGCAGGAAGCACACCTGTGCCATTTCTGGGACTCTG ATTGATCCAGCTGTGGACATTGGAAGGCGAAGGAAGGGAGGTGGCTCCTGGGTCATCTTTCACAAGGCTCAAGACTTCAACCTGCAGATG TATCTTTTTCCCTCCAGTTTTTCCTCTAGTTCTTTTAGGCATTTAAATTGTTTCTGTTACTCTGTGCAAAATAACTTTGAGATTGGACAA GAAGATGTTACTAAAGAGAAGTTCCTTTAAAAGGTCTTGTTCTTGTGTCAAAAAGCTGCAAGTTTGGTTTGTTCTCGTGTGTGATCATGA GTGCACAATGAAGAAGACCCTAGATGCTGCATTTTTTAGCTCTGAAGATTCCTTAGGTATCCCTGAAGACAGCTCGCTCAGATGATCAGC ATTTAGAGTGAAAACAAGGGCCCTTCATGGGTGAACATTAGAAAGAGCCAGGGTTCAAAGCTGGCGAATGGATGACGCACCCTAGCCACT GGCCCCTCTCTGTTTCATGTATTTCCAAAAGTTGTAAACTTTGATGGCTGATTTTTCGTAAGTCAGGTTTCTAAGTGAGCTCCCTGAGGT GCCAAGGCCATGGTGTCCGCCCTGCTGCGTCTGTTCGTCAGCTGAGTTCCTTGTGAATCTCTGTTTTAGGGTTTGGGGCTAGTGTGTTTG TGTTTCCATTCTAAGATTGAGTCTGGCAGTCCCTGTTTTTTTGCATTGGGGTAACTGCTCTTTGATTTTTTTTAATTGCAGTATTTGTGT GATTGCAATAATAAAGTTTGGTTTGGTTTTTACAGTCATGCGCAGGGACGATCCTTGTTCTCTGCTGTAAACTGTAAAAAGTTTATGGAG ACTTAAAGTCTTGATGTTGTGAAGCAGAGGTTATTTTGTGGAAAGATTAAAAGGATTTTGTTGGTACCTGGTTTTGTGTTGTGTATATAT ACATGAGGTTGAACAGTGAAAGGAAAGTTCAGTAGTGATGTTAGAAGGGTAACTATGACAAAGATACTTTTGAGATAACATTTAAAAGTA CTTTATATTTTACATAATAGCATGTTTCATTTTGATTAAAAGCTACCAAAGGAATTTTGATCATGGCATAAGTGTTTAAAGCAATATTTT CTGGAATATACCAAGTTTATATAATTTGATTTTGTGCTAAATTATTAAGAGTCTCTTTTTGAAACATGCGGGTTTGAAATATGACACCTT GTGGGTTTCCATATTAAAATCCTCACTCTTTAATTGTCATTTCTATCTTTGAAAATTTTCATTTATGAGTTCCATGATATGTGGTCTAAG AAAGACCAAACAGATTTCTATTTTTTTTTTCTTATAAGTTCGTTGTGTCTAGAGATTGTTAATATTGTAATTTAATGTAGACTTACTTTG AATAAAATTAGTTTAATTGGCCTTAAAATTACATTAATAAAACTTTGTGATATGCAAATG >41261_41261_4_KATNAL1-CUL4A_KATNAL1_chr13_30857753_ENST00000380617_CUL4A_chr13_113907396_ENST00000451881_length(amino acids)=267AA_BP=53 MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEF KEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQI QMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for KATNAL1-CUL4A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KATNAL1-CUL4A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KATNAL1-CUL4A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C0004238 | Atrial Fibrillation | 2 | CTD_human | |
| Tgene | C0235480 | Paroxysmal atrial fibrillation | 2 | CTD_human | |
| Tgene | C2585653 | Persistent atrial fibrillation | 2 | CTD_human | |
| Tgene | C3468561 | familial atrial fibrillation | 2 | CTD_human | |
| Tgene | C0014518 | Toxic Epidermal Necrolysis | 1 | CTD_human | |
| Tgene | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human | |
| Tgene | C1274933 | Drug-Induced Stevens Johnson Syndrome | 1 | CTD_human | |
| Tgene | C3658301 | Mycoplasma-Induced Stevens-Johnson Syndrome | 1 | CTD_human | |
| Tgene | C3658302 | Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum | 1 | CTD_human |
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