Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:BCAR3-SH2D3C (FusionGDB2 ID:HG8412TG10044)

Fusion Gene Summary for BCAR3-SH2D3C

check button Fusion gene summary
Fusion gene informationFusion gene name: BCAR3-SH2D3C
Fusion gene ID: hg8412tg10044
HgeneTgene
Gene symbol

BCAR3

SH2D3C

Gene ID

8412

10044

Gene nameBCAR3 adaptor protein, NSP family memberSH2 domain containing 3C
SynonymsAND-34|NSP2|SH2D3BCHAT|NSP3|PRO34088|SHEP1
Cytomap('BCAR3')('SH2D3C')

1p22.1

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionbreast cancer anti-estrogen resistance protein 3BCAR3, NSP family adaptor proteinSH2 domain-containing protein 3Bbreast cancer anti-estrogen resistance 3breast cancer antiestrogen resistance 3 proteindJ1033H22.2 (breast cancer anti-estrogen resistancSH2 domain-containing protein 3CSH2 domain-containing Eph receptor-binding protein 1novel SH2-containing protein 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000260502, ENST00000370243, 
ENST00000370244, ENST00000370247, 
ENST00000466632, ENST00000539242, 
Fusion gene scores* DoF score11 X 12 X 9=11885 X 5 X 4=100
# samples 125
** MAII scorelog2(12/1188*10)=-3.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BCAR3 [Title/Abstract] AND SH2D3C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBCAR3(94057822)-SH2D3C(130511944), # samples:1
Anticipated loss of major functional domain due to fusion event.BCAR3-SH2D3C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAR3-SH2D3C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAR3-SH2D3C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAR3-SH2D3C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAR3-SH2D3C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BCAR3-SH2D3C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BCAR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SH2D3C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-CJ-4870-01ABCAR3chr1

94057822

-SH2D3Cchr9

130511944

-


Top

Fusion Gene ORF analysis for BCAR3-SH2D3C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000260502ENST00000314830BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000260502ENST00000373276BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000260502ENST00000429553BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370243ENST00000314830BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370243ENST00000373276BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370243ENST00000429553BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370244ENST00000314830BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370244ENST00000373276BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370244ENST00000429553BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370247ENST00000314830BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370247ENST00000373276BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370247ENST00000429553BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-intronENST00000260502ENST00000471939BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-intronENST00000370243ENST00000471939BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-intronENST00000370244ENST00000471939BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-intronENST00000370247ENST00000471939BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
Frame-shiftENST00000260502ENST00000373274BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
Frame-shiftENST00000260502ENST00000373277BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
Frame-shiftENST00000260502ENST00000420366BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
Frame-shiftENST00000370244ENST00000373274BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
Frame-shiftENST00000370244ENST00000373277BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
Frame-shiftENST00000370244ENST00000420366BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
In-frameENST00000370243ENST00000373274BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
In-frameENST00000370243ENST00000373277BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
In-frameENST00000370243ENST00000420366BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
In-frameENST00000370247ENST00000373274BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
In-frameENST00000370247ENST00000373277BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
In-frameENST00000370247ENST00000420366BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-3CDSENST00000466632ENST00000373274BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-3CDSENST00000466632ENST00000373277BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-3CDSENST00000466632ENST00000420366BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-3CDSENST00000539242ENST00000373274BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-3CDSENST00000539242ENST00000373277BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-3CDSENST00000539242ENST00000420366BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-5UTRENST00000466632ENST00000314830BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-5UTRENST00000466632ENST00000373276BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-5UTRENST00000466632ENST00000429553BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-5UTRENST00000539242ENST00000314830BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-5UTRENST00000539242ENST00000373276BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-5UTRENST00000539242ENST00000429553BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-intronENST00000466632ENST00000471939BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-intronENST00000539242ENST00000471939BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370243BCAR3chr194057822-ENST00000373277SH2D3Cchr9130511944-3089761682659863
ENST00000370243BCAR3chr194057822-ENST00000373274SH2D3Cchr9130511944-3088761682659863
ENST00000370243BCAR3chr194057822-ENST00000420366SH2D3Cchr9130511944-3088761682659863
ENST00000370247BCAR3chr194057822-ENST00000373277SH2D3Cchr9130511944-27083801672278703
ENST00000370247BCAR3chr194057822-ENST00000373274SH2D3Cchr9130511944-27073801672278703
ENST00000370247BCAR3chr194057822-ENST00000420366SH2D3Cchr9130511944-27073801672278703

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370243ENST00000373277BCAR3chr194057822-SH2D3Cchr9130511944-0.0340954250.9659046
ENST00000370243ENST00000373274BCAR3chr194057822-SH2D3Cchr9130511944-0.034575630.96542436
ENST00000370243ENST00000420366BCAR3chr194057822-SH2D3Cchr9130511944-0.034575630.96542436
ENST00000370247ENST00000373277BCAR3chr194057822-SH2D3Cchr9130511944-0.0331054780.96689457
ENST00000370247ENST00000373274BCAR3chr194057822-SH2D3Cchr9130511944-0.0338466540.9661533
ENST00000370247ENST00000420366BCAR3chr194057822-SH2D3Cchr9130511944-0.0338466540.9661533

Top

Fusion Genomic Features for BCAR3-SH2D3C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for BCAR3-SH2D3C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:94057822/chr9:130511944)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000314830312586_854228861.0DomainRas-GEF
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000373274110220_31968701.0DomainSH2
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000373274110586_85468701.0DomainRas-GEF
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000373277211220_31971704.0DomainSH2
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000373277211586_85471704.0DomainRas-GEF
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000420366110220_31970703.0DomainSH2
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000420366110586_85470703.0DomainRas-GEF
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000429553211220_3190507.0DomainSH2
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000429553211586_8540507.0DomainRas-GEF

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBCAR3chr1:94057822chr9:130511944ENST00000260502-412479_482162826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370243-412479_482162826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370244-614479_482162826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370247-210479_48271735.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94057822chr9:130511944ENST00000539242-18479_4820502.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94057822chr9:130511944ENST00000260502-412154_253162826.0DomainSH2
HgeneBCAR3chr1:94057822chr9:130511944ENST00000260502-412548_818162826.0DomainRas-GEF
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370243-412154_253162826.0DomainSH2
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370243-412548_818162826.0DomainRas-GEF
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370244-614154_253162826.0DomainSH2
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370244-614548_818162826.0DomainRas-GEF
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370247-210154_25371735.0DomainSH2
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370247-210548_81871735.0DomainRas-GEF
HgeneBCAR3chr1:94057822chr9:130511944ENST00000539242-18154_2530502.0DomainSH2
HgeneBCAR3chr1:94057822chr9:130511944ENST00000539242-18548_8180502.0DomainRas-GEF
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000314830312220_319228861.0DomainSH2


Top

Fusion Gene Sequence for BCAR3-SH2D3C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9171_9171_1_BCAR3-SH2D3C_BCAR3_chr1_94057822_ENST00000370243_SH2D3C_chr9_130511944_ENST00000373274_length(transcript)=3088nt_BP=761nt
GAGCGCGCTGGGACTCCCCGAGACGTGGCCCACGGCGGGGAGCGCTCAGCGATTGGCGGCCAGGCATCTTGCTCGGTGGCACTCGAGCGG
CATCTTCCCGGGCGCTGGCCTCGCCCGACCCCCTGCCCGTCGGAGCTGCTCTGCCGGCCACCCCGCCCTGTCCCGCCCGTCCCCTCTTCG
CAGAAGCCGGCCGGGGTCGGGCAGATGCGAGGGCCCAGAGCGCTCTGGTGGAAGCCCAAGGCTCCGAGGAGGCGAGTTTCTCCGAGTTGA
GAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTCCCCCTGGCCTCATCCATGGACCTTCTGA
GCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTC
CTCCCATAAGGTCCTGTGATGACTTCAGTCACATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATG
GCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGA
AGTTCTCCAAGGAGAGGCACATCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACC
TGCGCAGCCATGCCTGGTACCACGGCCGCATCCCCCGACAGGTCTCGGAGACCTTGGTACAACGCAACGGCGACTTCCTCATCCGGGACT
CACTCACCAGCCTGGGCGACTATGTGCTCACGTGCCGCTGGCGCAACCAGGCCTTGCACTTCAAGATCAACAAGGTGGTGGTGAAGGCAG
GCGAGAGCTACACACACATCCAGTACCTGTTTGAGCAGGAGAGCTTTGACCACGTGCCCGCCCTCGTGCGCTATCATGTGGGCAGCCGCA
AGGCTGTGTCAGAGCAGAGTGGTGCCATCATCTACTGCCCGGTGAACCGCACCTTCCCACTGCGCTACCTCGAGGCCAGCTATGGCCTGG
GACAGGGGAGTAGCAAGCCTGCTAGCCCCGTCAGCCCCTCAGGCCCCAAGGGCAGCCACATGAAGCGGCGCAGCGTCACCATGACCGATG
GGCTCACTGCTGACAAGGTCACCCGCAGCGATGGCTGCCCCACCAGTACGTCGCTGCCCCGCCCTCGGGACTCCATCCGCAGCTGTGCCC
TCAGCATGGACCAGATCCCAGACCTGCACTCACCCATGTCGCCCATCTCCGAGAGCCCTAGCTCCCCTGCCTACAGCACTGTAACCCGTG
TCCATGCCGCCCCTGCAGCCCCTTCTGCCACAGCATTGCCTGCCTCCCCTGTCGCCCGCCGTTCCAGTGAGCCCCAGCTGTGTCCCGGAA
GTGCCCCAAAGACCCATGGGGAGTCAGACAAGGGCCCCCACACCAGCCCCTCCCACACCCTTGGCAAGGCCTCCCCGTCACCATCACTCA
GCAGCTACAGTGACCCGGACTCTGGCCACTACTGCCAGCTCCAGCCTCCCGTGCGTGGCAGCCGAGAGTGGGCAGCGACTGAGACCTCCA
GCCAGCAGGCCAGGAGCTATGGGGAGAGGCTAAAGGAACTGTCAGAAAATGGGGCCCCTGAAGGGGACTGGGGCAAGACCTTCACAGTCC
CCATCGTGGAAGTCACTTCTTCCTTCAACCCGGCCACCTTCCAGTCACTACTGATCCCCAGGGATAACCGGCCACTGGAGGTGGGCCTTC
TGCGCAAGGTCAAGGAGCTGCTGGCAGAAGTGGATGCCCGGACGCTGGCCCGGCATGTCACCAAGGTGGACTGCCTGGTTGCTAGGATAC
TGGGCGTTACCAAGGAGATGCAGACCCTAATGGGAGTCCGCTGGGGCATGGAACTGCTCACCCTCCCCCATGGCCGGCAGCTACGCCTAG
ACCTGCTGGAAAGGTTCCACACCATGTCCATCATGCTGGCCGTGGACATCCTGGGCTGCACCGGCTCTGCGGAGGAGCGGGCAGCGCTGC
TGCACAAGACCATTCAGCTGGCGGCCGAGCTGCGGGGGACTATGGGCAACATGTTCAGCTTCGCGGCGGTCATGGGTGCCCTGGACATGG
CCCAGATTTCTCGGCTGGAGCAGACATGGGTGACCCTGCGGCAGCGACACACAGAGGGTGCCATCCTGTACGAGAAGAAGCTCAAGCCTT
TTCTCAAGAGCCTCAACGAGGGCAAAGAAGGCCCGCCGCTGAGCAACACCACGTTTCCTCATGTGCTGCCCCTCATCACCCTGCTGGAGT
GTGACTCGGCCCCACCAGAGGGCCCTGAGCCCTGGGGCAGCACGGAGCACGGCGTGGAGGTGGTGCTGGCTCACCTGGAGGCCGCCCGCA
CAGTGGCACACCACGGAGGCCTGTACCACACCAATGCTGAAGTCAAGCTGCAGGGGTTCCAGGCCCGGCCGGAGCTCCTGGAGGTGTTCA
GCACGGAGTTCCAGATGCGCCTTCTCTGGGGCAGTCAGGGTGCCAGCAGCAGCCAGGCCCGGCGCTATGAGAAGTTCGACAAGGTCCTCA
CTGCCCTGTCCCACAAGCTGGAACCTGCTGTCCGCTCCAGCGAGCTGTGACCCCAGGGACATTTCCCCTCTGCAGCTGCGGACAGCGTCA
GGGGCAGAGGGGCACACAACTTTCCCCAGAGCACCCCAAGGACACTGTGATCAACCCGAGAATGTTCTGGGTTCAACTCAAGCATCTCCC
TTGCACCTCCAGGGTCCTGCGTGGACTCTGGGTTCCATCCCACCTGCTACATGCTCACCAGGTCTCCATTGAGGAAGAACAGGAACGCCG
GTTCCCCCACCAGCTTTTGCTGCTCCCCTTCCTGCTGGGGTTCCCTGTTTTCGAGCCATGGGAGGCAGGCTGCTCACGCCTCCTCACTCT
CTGTCTGTCCCTCACCAACACCAAGGCCTCCATCTCACTGTAAATAAGTCTCTGTTCTGTAAATAGATGTACAGAAGCCATGTTATTTCT
TTCATATAATAAACTTTTATGACTCTTT

>9171_9171_1_BCAR3-SH2D3C_BCAR3_chr1_94057822_ENST00000370243_SH2D3C_chr9_130511944_ENST00000373274_length(amino acids)=863AA_BP=188
MLGGTRAASSRALASPDPLPVGAALPATPPCPARPLFAEAGRGRADARAQSALVEAQGSEEASFSELRIMAAGKFASLPRNMPVNHQFPL
ASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLL
DPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI
NKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKR
RSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSS
EPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGD
WGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLP
HGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAIL
YEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR
PELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL

--------------------------------------------------------------
>9171_9171_2_BCAR3-SH2D3C_BCAR3_chr1_94057822_ENST00000370243_SH2D3C_chr9_130511944_ENST00000373277_length(transcript)=3089nt_BP=761nt
GAGCGCGCTGGGACTCCCCGAGACGTGGCCCACGGCGGGGAGCGCTCAGCGATTGGCGGCCAGGCATCTTGCTCGGTGGCACTCGAGCGG
CATCTTCCCGGGCGCTGGCCTCGCCCGACCCCCTGCCCGTCGGAGCTGCTCTGCCGGCCACCCCGCCCTGTCCCGCCCGTCCCCTCTTCG
CAGAAGCCGGCCGGGGTCGGGCAGATGCGAGGGCCCAGAGCGCTCTGGTGGAAGCCCAAGGCTCCGAGGAGGCGAGTTTCTCCGAGTTGA
GAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTCCCCCTGGCCTCATCCATGGACCTTCTGA
GCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTC
CTCCCATAAGGTCCTGTGATGACTTCAGTCACATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATG
GCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGA
AGTTCTCCAAGGAGAGGCACATCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACC
TGCGCAGCCATGCCTGGTACCACGGCCGCATCCCCCGACAGGTCTCGGAGACCTTGGTACAACGCAACGGCGACTTCCTCATCCGGGACT
CACTCACCAGCCTGGGCGACTATGTGCTCACGTGCCGCTGGCGCAACCAGGCCTTGCACTTCAAGATCAACAAGGTGGTGGTGAAGGCAG
GCGAGAGCTACACACACATCCAGTACCTGTTTGAGCAGGAGAGCTTTGACCACGTGCCCGCCCTCGTGCGCTATCATGTGGGCAGCCGCA
AGGCTGTGTCAGAGCAGAGTGGTGCCATCATCTACTGCCCGGTGAACCGCACCTTCCCACTGCGCTACCTCGAGGCCAGCTATGGCCTGG
GACAGGGGAGTAGCAAGCCTGCTAGCCCCGTCAGCCCCTCAGGCCCCAAGGGCAGCCACATGAAGCGGCGCAGCGTCACCATGACCGATG
GGCTCACTGCTGACAAGGTCACCCGCAGCGATGGCTGCCCCACCAGTACGTCGCTGCCCCGCCCTCGGGACTCCATCCGCAGCTGTGCCC
TCAGCATGGACCAGATCCCAGACCTGCACTCACCCATGTCGCCCATCTCCGAGAGCCCTAGCTCCCCTGCCTACAGCACTGTAACCCGTG
TCCATGCCGCCCCTGCAGCCCCTTCTGCCACAGCATTGCCTGCCTCCCCTGTCGCCCGCCGTTCCAGTGAGCCCCAGCTGTGTCCCGGAA
GTGCCCCAAAGACCCATGGGGAGTCAGACAAGGGCCCCCACACCAGCCCCTCCCACACCCTTGGCAAGGCCTCCCCGTCACCATCACTCA
GCAGCTACAGTGACCCGGACTCTGGCCACTACTGCCAGCTCCAGCCTCCCGTGCGTGGCAGCCGAGAGTGGGCAGCGACTGAGACCTCCA
GCCAGCAGGCCAGGAGCTATGGGGAGAGGCTAAAGGAACTGTCAGAAAATGGGGCCCCTGAAGGGGACTGGGGCAAGACCTTCACAGTCC
CCATCGTGGAAGTCACTTCTTCCTTCAACCCGGCCACCTTCCAGTCACTACTGATCCCCAGGGATAACCGGCCACTGGAGGTGGGCCTTC
TGCGCAAGGTCAAGGAGCTGCTGGCAGAAGTGGATGCCCGGACGCTGGCCCGGCATGTCACCAAGGTGGACTGCCTGGTTGCTAGGATAC
TGGGCGTTACCAAGGAGATGCAGACCCTAATGGGAGTCCGCTGGGGCATGGAACTGCTCACCCTCCCCCATGGCCGGCAGCTACGCCTAG
ACCTGCTGGAAAGGTTCCACACCATGTCCATCATGCTGGCCGTGGACATCCTGGGCTGCACCGGCTCTGCGGAGGAGCGGGCAGCGCTGC
TGCACAAGACCATTCAGCTGGCGGCCGAGCTGCGGGGGACTATGGGCAACATGTTCAGCTTCGCGGCGGTCATGGGTGCCCTGGACATGG
CCCAGATTTCTCGGCTGGAGCAGACATGGGTGACCCTGCGGCAGCGACACACAGAGGGTGCCATCCTGTACGAGAAGAAGCTCAAGCCTT
TTCTCAAGAGCCTCAACGAGGGCAAAGAAGGCCCGCCGCTGAGCAACACCACGTTTCCTCATGTGCTGCCCCTCATCACCCTGCTGGAGT
GTGACTCGGCCCCACCAGAGGGCCCTGAGCCCTGGGGCAGCACGGAGCACGGCGTGGAGGTGGTGCTGGCTCACCTGGAGGCCGCCCGCA
CAGTGGCACACCACGGAGGCCTGTACCACACCAATGCTGAAGTCAAGCTGCAGGGGTTCCAGGCCCGGCCGGAGCTCCTGGAGGTGTTCA
GCACGGAGTTCCAGATGCGCCTTCTCTGGGGCAGTCAGGGTGCCAGCAGCAGCCAGGCCCGGCGCTATGAGAAGTTCGACAAGGTCCTCA
CTGCCCTGTCCCACAAGCTGGAACCTGCTGTCCGCTCCAGCGAGCTGTGACCCCAGGGACATTTCCCCTCTGCAGCTGCGGACAGCGTCA
GGGGCAGAGGGGCACACAACTTTCCCCAGAGCACCCCAAGGACACTGTGATCAACCCGAGAATGTTCTGGGTTCAACTCAAGCATCTCCC
TTGCACCTCCAGGGTCCTGCGTGGACTCTGGGTTCCATCCCACCTGCTACATGCTCACCAGGTCTCCATTGAGGAAGAACAGGAACGCCG
GTTCCCCCACCAGCTTTTGCTGCTCCCCTTCCTGCTGGGGTTCCCTGTTTTCGAGCCATGGGAGGCAGGCTGCTCACGCCTCCTCACTCT
CTGTCTGTCCCTCACCAACACCAAGGCCTCCATCTCACTGTAAATAAGTCTCTGTTCTGTAAATAGATGTACAGAAGCCATGTTATTTCT
TTCATATAATAAACTTTTATGACTCTTTA

>9171_9171_2_BCAR3-SH2D3C_BCAR3_chr1_94057822_ENST00000370243_SH2D3C_chr9_130511944_ENST00000373277_length(amino acids)=863AA_BP=188
MLGGTRAASSRALASPDPLPVGAALPATPPCPARPLFAEAGRGRADARAQSALVEAQGSEEASFSELRIMAAGKFASLPRNMPVNHQFPL
ASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLL
DPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI
NKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKR
RSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSS
EPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGD
WGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLP
HGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAIL
YEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR
PELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL

--------------------------------------------------------------
>9171_9171_3_BCAR3-SH2D3C_BCAR3_chr1_94057822_ENST00000370243_SH2D3C_chr9_130511944_ENST00000420366_length(transcript)=3088nt_BP=761nt
GAGCGCGCTGGGACTCCCCGAGACGTGGCCCACGGCGGGGAGCGCTCAGCGATTGGCGGCCAGGCATCTTGCTCGGTGGCACTCGAGCGG
CATCTTCCCGGGCGCTGGCCTCGCCCGACCCCCTGCCCGTCGGAGCTGCTCTGCCGGCCACCCCGCCCTGTCCCGCCCGTCCCCTCTTCG
CAGAAGCCGGCCGGGGTCGGGCAGATGCGAGGGCCCAGAGCGCTCTGGTGGAAGCCCAAGGCTCCGAGGAGGCGAGTTTCTCCGAGTTGA
GAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTCCCCCTGGCCTCATCCATGGACCTTCTGA
GCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTC
CTCCCATAAGGTCCTGTGATGACTTCAGTCACATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATG
GCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGA
AGTTCTCCAAGGAGAGGCACATCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACC
TGCGCAGCCATGCCTGGTACCACGGCCGCATCCCCCGACAGGTCTCGGAGACCTTGGTACAACGCAACGGCGACTTCCTCATCCGGGACT
CACTCACCAGCCTGGGCGACTATGTGCTCACGTGCCGCTGGCGCAACCAGGCCTTGCACTTCAAGATCAACAAGGTGGTGGTGAAGGCAG
GCGAGAGCTACACACACATCCAGTACCTGTTTGAGCAGGAGAGCTTTGACCACGTGCCCGCCCTCGTGCGCTATCATGTGGGCAGCCGCA
AGGCTGTGTCAGAGCAGAGTGGTGCCATCATCTACTGCCCGGTGAACCGCACCTTCCCACTGCGCTACCTCGAGGCCAGCTATGGCCTGG
GACAGGGGAGTAGCAAGCCTGCTAGCCCCGTCAGCCCCTCAGGCCCCAAGGGCAGCCACATGAAGCGGCGCAGCGTCACCATGACCGATG
GGCTCACTGCTGACAAGGTCACCCGCAGCGATGGCTGCCCCACCAGTACGTCGCTGCCCCGCCCTCGGGACTCCATCCGCAGCTGTGCCC
TCAGCATGGACCAGATCCCAGACCTGCACTCACCCATGTCGCCCATCTCCGAGAGCCCTAGCTCCCCTGCCTACAGCACTGTAACCCGTG
TCCATGCCGCCCCTGCAGCCCCTTCTGCCACAGCATTGCCTGCCTCCCCTGTCGCCCGCCGTTCCAGTGAGCCCCAGCTGTGTCCCGGAA
GTGCCCCAAAGACCCATGGGGAGTCAGACAAGGGCCCCCACACCAGCCCCTCCCACACCCTTGGCAAGGCCTCCCCGTCACCATCACTCA
GCAGCTACAGTGACCCGGACTCTGGCCACTACTGCCAGCTCCAGCCTCCCGTGCGTGGCAGCCGAGAGTGGGCAGCGACTGAGACCTCCA
GCCAGCAGGCCAGGAGCTATGGGGAGAGGCTAAAGGAACTGTCAGAAAATGGGGCCCCTGAAGGGGACTGGGGCAAGACCTTCACAGTCC
CCATCGTGGAAGTCACTTCTTCCTTCAACCCGGCCACCTTCCAGTCACTACTGATCCCCAGGGATAACCGGCCACTGGAGGTGGGCCTTC
TGCGCAAGGTCAAGGAGCTGCTGGCAGAAGTGGATGCCCGGACGCTGGCCCGGCATGTCACCAAGGTGGACTGCCTGGTTGCTAGGATAC
TGGGCGTTACCAAGGAGATGCAGACCCTAATGGGAGTCCGCTGGGGCATGGAACTGCTCACCCTCCCCCATGGCCGGCAGCTACGCCTAG
ACCTGCTGGAAAGGTTCCACACCATGTCCATCATGCTGGCCGTGGACATCCTGGGCTGCACCGGCTCTGCGGAGGAGCGGGCAGCGCTGC
TGCACAAGACCATTCAGCTGGCGGCCGAGCTGCGGGGGACTATGGGCAACATGTTCAGCTTCGCGGCGGTCATGGGTGCCCTGGACATGG
CCCAGATTTCTCGGCTGGAGCAGACATGGGTGACCCTGCGGCAGCGACACACAGAGGGTGCCATCCTGTACGAGAAGAAGCTCAAGCCTT
TTCTCAAGAGCCTCAACGAGGGCAAAGAAGGCCCGCCGCTGAGCAACACCACGTTTCCTCATGTGCTGCCCCTCATCACCCTGCTGGAGT
GTGACTCGGCCCCACCAGAGGGCCCTGAGCCCTGGGGCAGCACGGAGCACGGCGTGGAGGTGGTGCTGGCTCACCTGGAGGCCGCCCGCA
CAGTGGCACACCACGGAGGCCTGTACCACACCAATGCTGAAGTCAAGCTGCAGGGGTTCCAGGCCCGGCCGGAGCTCCTGGAGGTGTTCA
GCACGGAGTTCCAGATGCGCCTTCTCTGGGGCAGTCAGGGTGCCAGCAGCAGCCAGGCCCGGCGCTATGAGAAGTTCGACAAGGTCCTCA
CTGCCCTGTCCCACAAGCTGGAACCTGCTGTCCGCTCCAGCGAGCTGTGACCCCAGGGACATTTCCCCTCTGCAGCTGCGGACAGCGTCA
GGGGCAGAGGGGCACACAACTTTCCCCAGAGCACCCCAAGGACACTGTGATCAACCCGAGAATGTTCTGGGTTCAACTCAAGCATCTCCC
TTGCACCTCCAGGGTCCTGCGTGGACTCTGGGTTCCATCCCACCTGCTACATGCTCACCAGGTCTCCATTGAGGAAGAACAGGAACGCCG
GTTCCCCCACCAGCTTTTGCTGCTCCCCTTCCTGCTGGGGTTCCCTGTTTTCGAGCCATGGGAGGCAGGCTGCTCACGCCTCCTCACTCT
CTGTCTGTCCCTCACCAACACCAAGGCCTCCATCTCACTGTAAATAAGTCTCTGTTCTGTAAATAGATGTACAGAAGCCATGTTATTTCT
TTCATATAATAAACTTTTATGACTCTTT

>9171_9171_3_BCAR3-SH2D3C_BCAR3_chr1_94057822_ENST00000370243_SH2D3C_chr9_130511944_ENST00000420366_length(amino acids)=863AA_BP=188
MLGGTRAASSRALASPDPLPVGAALPATPPCPARPLFAEAGRGRADARAQSALVEAQGSEEASFSELRIMAAGKFASLPRNMPVNHQFPL
ASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLL
DPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI
NKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKR
RSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSS
EPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGD
WGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLP
HGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAIL
YEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR
PELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL

--------------------------------------------------------------
>9171_9171_4_BCAR3-SH2D3C_BCAR3_chr1_94057822_ENST00000370247_SH2D3C_chr9_130511944_ENST00000373274_length(transcript)=2707nt_BP=380nt
AGACTAGCCTGGGAGAAGGAGCCGACTCACTCCCCCGGCTGCCGACTTCCCTGACTTCTGGGCAGAAACAGCACAGCTGCTGTGGTGGGC
TAGGGCTTTAACGTCCGAAGCCCCCTTTCTTTTAACCCTAAAGAAAGTGTGTGGTCCCCGGGACTGAAGACCGAAAGATGCCTAAGGAAT
GCAGTGCTTTCCACGCCCTCTCAGCAGCTCTGTGCTGCTTCTATCACCGCAAGTCTTTCATTGGAGTCAAGTTCTCCAAGGAGAGGCACA
TCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACCTGCGCAGCCATGCCTGGTACC
ACGGCCGCATCCCCCGACAGGTCTCGGAGACCTTGGTACAACGCAACGGCGACTTCCTCATCCGGGACTCACTCACCAGCCTGGGCGACT
ATGTGCTCACGTGCCGCTGGCGCAACCAGGCCTTGCACTTCAAGATCAACAAGGTGGTGGTGAAGGCAGGCGAGAGCTACACACACATCC
AGTACCTGTTTGAGCAGGAGAGCTTTGACCACGTGCCCGCCCTCGTGCGCTATCATGTGGGCAGCCGCAAGGCTGTGTCAGAGCAGAGTG
GTGCCATCATCTACTGCCCGGTGAACCGCACCTTCCCACTGCGCTACCTCGAGGCCAGCTATGGCCTGGGACAGGGGAGTAGCAAGCCTG
CTAGCCCCGTCAGCCCCTCAGGCCCCAAGGGCAGCCACATGAAGCGGCGCAGCGTCACCATGACCGATGGGCTCACTGCTGACAAGGTCA
CCCGCAGCGATGGCTGCCCCACCAGTACGTCGCTGCCCCGCCCTCGGGACTCCATCCGCAGCTGTGCCCTCAGCATGGACCAGATCCCAG
ACCTGCACTCACCCATGTCGCCCATCTCCGAGAGCCCTAGCTCCCCTGCCTACAGCACTGTAACCCGTGTCCATGCCGCCCCTGCAGCCC
CTTCTGCCACAGCATTGCCTGCCTCCCCTGTCGCCCGCCGTTCCAGTGAGCCCCAGCTGTGTCCCGGAAGTGCCCCAAAGACCCATGGGG
AGTCAGACAAGGGCCCCCACACCAGCCCCTCCCACACCCTTGGCAAGGCCTCCCCGTCACCATCACTCAGCAGCTACAGTGACCCGGACT
CTGGCCACTACTGCCAGCTCCAGCCTCCCGTGCGTGGCAGCCGAGAGTGGGCAGCGACTGAGACCTCCAGCCAGCAGGCCAGGAGCTATG
GGGAGAGGCTAAAGGAACTGTCAGAAAATGGGGCCCCTGAAGGGGACTGGGGCAAGACCTTCACAGTCCCCATCGTGGAAGTCACTTCTT
CCTTCAACCCGGCCACCTTCCAGTCACTACTGATCCCCAGGGATAACCGGCCACTGGAGGTGGGCCTTCTGCGCAAGGTCAAGGAGCTGC
TGGCAGAAGTGGATGCCCGGACGCTGGCCCGGCATGTCACCAAGGTGGACTGCCTGGTTGCTAGGATACTGGGCGTTACCAAGGAGATGC
AGACCCTAATGGGAGTCCGCTGGGGCATGGAACTGCTCACCCTCCCCCATGGCCGGCAGCTACGCCTAGACCTGCTGGAAAGGTTCCACA
CCATGTCCATCATGCTGGCCGTGGACATCCTGGGCTGCACCGGCTCTGCGGAGGAGCGGGCAGCGCTGCTGCACAAGACCATTCAGCTGG
CGGCCGAGCTGCGGGGGACTATGGGCAACATGTTCAGCTTCGCGGCGGTCATGGGTGCCCTGGACATGGCCCAGATTTCTCGGCTGGAGC
AGACATGGGTGACCCTGCGGCAGCGACACACAGAGGGTGCCATCCTGTACGAGAAGAAGCTCAAGCCTTTTCTCAAGAGCCTCAACGAGG
GCAAAGAAGGCCCGCCGCTGAGCAACACCACGTTTCCTCATGTGCTGCCCCTCATCACCCTGCTGGAGTGTGACTCGGCCCCACCAGAGG
GCCCTGAGCCCTGGGGCAGCACGGAGCACGGCGTGGAGGTGGTGCTGGCTCACCTGGAGGCCGCCCGCACAGTGGCACACCACGGAGGCC
TGTACCACACCAATGCTGAAGTCAAGCTGCAGGGGTTCCAGGCCCGGCCGGAGCTCCTGGAGGTGTTCAGCACGGAGTTCCAGATGCGCC
TTCTCTGGGGCAGTCAGGGTGCCAGCAGCAGCCAGGCCCGGCGCTATGAGAAGTTCGACAAGGTCCTCACTGCCCTGTCCCACAAGCTGG
AACCTGCTGTCCGCTCCAGCGAGCTGTGACCCCAGGGACATTTCCCCTCTGCAGCTGCGGACAGCGTCAGGGGCAGAGGGGCACACAACT
TTCCCCAGAGCACCCCAAGGACACTGTGATCAACCCGAGAATGTTCTGGGTTCAACTCAAGCATCTCCCTTGCACCTCCAGGGTCCTGCG
TGGACTCTGGGTTCCATCCCACCTGCTACATGCTCACCAGGTCTCCATTGAGGAAGAACAGGAACGCCGGTTCCCCCACCAGCTTTTGCT
GCTCCCCTTCCTGCTGGGGTTCCCTGTTTTCGAGCCATGGGAGGCAGGCTGCTCACGCCTCCTCACTCTCTGTCTGTCCCTCACCAACAC
CAAGGCCTCCATCTCACTGTAAATAAGTCTCTGTTCTGTAAATAGATGTACAGAAGCCATGTTATTTCTTTCATATAATAAACTTTTATG
ACTCTTT

>9171_9171_4_BCAR3-SH2D3C_BCAR3_chr1_94057822_ENST00000370247_SH2D3C_chr9_130511944_ENST00000373274_length(amino acids)=703AA_BP=4
MPKECSAFHALSAALCCFYHRKSFIGVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSETLVQRNGDFLIRDSLT
SLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG
SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHA
APAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ
ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGV
TKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI
SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVA
HHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL

--------------------------------------------------------------
>9171_9171_5_BCAR3-SH2D3C_BCAR3_chr1_94057822_ENST00000370247_SH2D3C_chr9_130511944_ENST00000373277_length(transcript)=2708nt_BP=380nt
AGACTAGCCTGGGAGAAGGAGCCGACTCACTCCCCCGGCTGCCGACTTCCCTGACTTCTGGGCAGAAACAGCACAGCTGCTGTGGTGGGC
TAGGGCTTTAACGTCCGAAGCCCCCTTTCTTTTAACCCTAAAGAAAGTGTGTGGTCCCCGGGACTGAAGACCGAAAGATGCCTAAGGAAT
GCAGTGCTTTCCACGCCCTCTCAGCAGCTCTGTGCTGCTTCTATCACCGCAAGTCTTTCATTGGAGTCAAGTTCTCCAAGGAGAGGCACA
TCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACCTGCGCAGCCATGCCTGGTACC
ACGGCCGCATCCCCCGACAGGTCTCGGAGACCTTGGTACAACGCAACGGCGACTTCCTCATCCGGGACTCACTCACCAGCCTGGGCGACT
ATGTGCTCACGTGCCGCTGGCGCAACCAGGCCTTGCACTTCAAGATCAACAAGGTGGTGGTGAAGGCAGGCGAGAGCTACACACACATCC
AGTACCTGTTTGAGCAGGAGAGCTTTGACCACGTGCCCGCCCTCGTGCGCTATCATGTGGGCAGCCGCAAGGCTGTGTCAGAGCAGAGTG
GTGCCATCATCTACTGCCCGGTGAACCGCACCTTCCCACTGCGCTACCTCGAGGCCAGCTATGGCCTGGGACAGGGGAGTAGCAAGCCTG
CTAGCCCCGTCAGCCCCTCAGGCCCCAAGGGCAGCCACATGAAGCGGCGCAGCGTCACCATGACCGATGGGCTCACTGCTGACAAGGTCA
CCCGCAGCGATGGCTGCCCCACCAGTACGTCGCTGCCCCGCCCTCGGGACTCCATCCGCAGCTGTGCCCTCAGCATGGACCAGATCCCAG
ACCTGCACTCACCCATGTCGCCCATCTCCGAGAGCCCTAGCTCCCCTGCCTACAGCACTGTAACCCGTGTCCATGCCGCCCCTGCAGCCC
CTTCTGCCACAGCATTGCCTGCCTCCCCTGTCGCCCGCCGTTCCAGTGAGCCCCAGCTGTGTCCCGGAAGTGCCCCAAAGACCCATGGGG
AGTCAGACAAGGGCCCCCACACCAGCCCCTCCCACACCCTTGGCAAGGCCTCCCCGTCACCATCACTCAGCAGCTACAGTGACCCGGACT
CTGGCCACTACTGCCAGCTCCAGCCTCCCGTGCGTGGCAGCCGAGAGTGGGCAGCGACTGAGACCTCCAGCCAGCAGGCCAGGAGCTATG
GGGAGAGGCTAAAGGAACTGTCAGAAAATGGGGCCCCTGAAGGGGACTGGGGCAAGACCTTCACAGTCCCCATCGTGGAAGTCACTTCTT
CCTTCAACCCGGCCACCTTCCAGTCACTACTGATCCCCAGGGATAACCGGCCACTGGAGGTGGGCCTTCTGCGCAAGGTCAAGGAGCTGC
TGGCAGAAGTGGATGCCCGGACGCTGGCCCGGCATGTCACCAAGGTGGACTGCCTGGTTGCTAGGATACTGGGCGTTACCAAGGAGATGC
AGACCCTAATGGGAGTCCGCTGGGGCATGGAACTGCTCACCCTCCCCCATGGCCGGCAGCTACGCCTAGACCTGCTGGAAAGGTTCCACA
CCATGTCCATCATGCTGGCCGTGGACATCCTGGGCTGCACCGGCTCTGCGGAGGAGCGGGCAGCGCTGCTGCACAAGACCATTCAGCTGG
CGGCCGAGCTGCGGGGGACTATGGGCAACATGTTCAGCTTCGCGGCGGTCATGGGTGCCCTGGACATGGCCCAGATTTCTCGGCTGGAGC
AGACATGGGTGACCCTGCGGCAGCGACACACAGAGGGTGCCATCCTGTACGAGAAGAAGCTCAAGCCTTTTCTCAAGAGCCTCAACGAGG
GCAAAGAAGGCCCGCCGCTGAGCAACACCACGTTTCCTCATGTGCTGCCCCTCATCACCCTGCTGGAGTGTGACTCGGCCCCACCAGAGG
GCCCTGAGCCCTGGGGCAGCACGGAGCACGGCGTGGAGGTGGTGCTGGCTCACCTGGAGGCCGCCCGCACAGTGGCACACCACGGAGGCC
TGTACCACACCAATGCTGAAGTCAAGCTGCAGGGGTTCCAGGCCCGGCCGGAGCTCCTGGAGGTGTTCAGCACGGAGTTCCAGATGCGCC
TTCTCTGGGGCAGTCAGGGTGCCAGCAGCAGCCAGGCCCGGCGCTATGAGAAGTTCGACAAGGTCCTCACTGCCCTGTCCCACAAGCTGG
AACCTGCTGTCCGCTCCAGCGAGCTGTGACCCCAGGGACATTTCCCCTCTGCAGCTGCGGACAGCGTCAGGGGCAGAGGGGCACACAACT
TTCCCCAGAGCACCCCAAGGACACTGTGATCAACCCGAGAATGTTCTGGGTTCAACTCAAGCATCTCCCTTGCACCTCCAGGGTCCTGCG
TGGACTCTGGGTTCCATCCCACCTGCTACATGCTCACCAGGTCTCCATTGAGGAAGAACAGGAACGCCGGTTCCCCCACCAGCTTTTGCT
GCTCCCCTTCCTGCTGGGGTTCCCTGTTTTCGAGCCATGGGAGGCAGGCTGCTCACGCCTCCTCACTCTCTGTCTGTCCCTCACCAACAC
CAAGGCCTCCATCTCACTGTAAATAAGTCTCTGTTCTGTAAATAGATGTACAGAAGCCATGTTATTTCTTTCATATAATAAACTTTTATG
ACTCTTTA

>9171_9171_5_BCAR3-SH2D3C_BCAR3_chr1_94057822_ENST00000370247_SH2D3C_chr9_130511944_ENST00000373277_length(amino acids)=703AA_BP=4
MPKECSAFHALSAALCCFYHRKSFIGVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSETLVQRNGDFLIRDSLT
SLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG
SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHA
APAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ
ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGV
TKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI
SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVA
HHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL

--------------------------------------------------------------
>9171_9171_6_BCAR3-SH2D3C_BCAR3_chr1_94057822_ENST00000370247_SH2D3C_chr9_130511944_ENST00000420366_length(transcript)=2707nt_BP=380nt
AGACTAGCCTGGGAGAAGGAGCCGACTCACTCCCCCGGCTGCCGACTTCCCTGACTTCTGGGCAGAAACAGCACAGCTGCTGTGGTGGGC
TAGGGCTTTAACGTCCGAAGCCCCCTTTCTTTTAACCCTAAAGAAAGTGTGTGGTCCCCGGGACTGAAGACCGAAAGATGCCTAAGGAAT
GCAGTGCTTTCCACGCCCTCTCAGCAGCTCTGTGCTGCTTCTATCACCGCAAGTCTTTCATTGGAGTCAAGTTCTCCAAGGAGAGGCACA
TCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACCTGCGCAGCCATGCCTGGTACC
ACGGCCGCATCCCCCGACAGGTCTCGGAGACCTTGGTACAACGCAACGGCGACTTCCTCATCCGGGACTCACTCACCAGCCTGGGCGACT
ATGTGCTCACGTGCCGCTGGCGCAACCAGGCCTTGCACTTCAAGATCAACAAGGTGGTGGTGAAGGCAGGCGAGAGCTACACACACATCC
AGTACCTGTTTGAGCAGGAGAGCTTTGACCACGTGCCCGCCCTCGTGCGCTATCATGTGGGCAGCCGCAAGGCTGTGTCAGAGCAGAGTG
GTGCCATCATCTACTGCCCGGTGAACCGCACCTTCCCACTGCGCTACCTCGAGGCCAGCTATGGCCTGGGACAGGGGAGTAGCAAGCCTG
CTAGCCCCGTCAGCCCCTCAGGCCCCAAGGGCAGCCACATGAAGCGGCGCAGCGTCACCATGACCGATGGGCTCACTGCTGACAAGGTCA
CCCGCAGCGATGGCTGCCCCACCAGTACGTCGCTGCCCCGCCCTCGGGACTCCATCCGCAGCTGTGCCCTCAGCATGGACCAGATCCCAG
ACCTGCACTCACCCATGTCGCCCATCTCCGAGAGCCCTAGCTCCCCTGCCTACAGCACTGTAACCCGTGTCCATGCCGCCCCTGCAGCCC
CTTCTGCCACAGCATTGCCTGCCTCCCCTGTCGCCCGCCGTTCCAGTGAGCCCCAGCTGTGTCCCGGAAGTGCCCCAAAGACCCATGGGG
AGTCAGACAAGGGCCCCCACACCAGCCCCTCCCACACCCTTGGCAAGGCCTCCCCGTCACCATCACTCAGCAGCTACAGTGACCCGGACT
CTGGCCACTACTGCCAGCTCCAGCCTCCCGTGCGTGGCAGCCGAGAGTGGGCAGCGACTGAGACCTCCAGCCAGCAGGCCAGGAGCTATG
GGGAGAGGCTAAAGGAACTGTCAGAAAATGGGGCCCCTGAAGGGGACTGGGGCAAGACCTTCACAGTCCCCATCGTGGAAGTCACTTCTT
CCTTCAACCCGGCCACCTTCCAGTCACTACTGATCCCCAGGGATAACCGGCCACTGGAGGTGGGCCTTCTGCGCAAGGTCAAGGAGCTGC
TGGCAGAAGTGGATGCCCGGACGCTGGCCCGGCATGTCACCAAGGTGGACTGCCTGGTTGCTAGGATACTGGGCGTTACCAAGGAGATGC
AGACCCTAATGGGAGTCCGCTGGGGCATGGAACTGCTCACCCTCCCCCATGGCCGGCAGCTACGCCTAGACCTGCTGGAAAGGTTCCACA
CCATGTCCATCATGCTGGCCGTGGACATCCTGGGCTGCACCGGCTCTGCGGAGGAGCGGGCAGCGCTGCTGCACAAGACCATTCAGCTGG
CGGCCGAGCTGCGGGGGACTATGGGCAACATGTTCAGCTTCGCGGCGGTCATGGGTGCCCTGGACATGGCCCAGATTTCTCGGCTGGAGC
AGACATGGGTGACCCTGCGGCAGCGACACACAGAGGGTGCCATCCTGTACGAGAAGAAGCTCAAGCCTTTTCTCAAGAGCCTCAACGAGG
GCAAAGAAGGCCCGCCGCTGAGCAACACCACGTTTCCTCATGTGCTGCCCCTCATCACCCTGCTGGAGTGTGACTCGGCCCCACCAGAGG
GCCCTGAGCCCTGGGGCAGCACGGAGCACGGCGTGGAGGTGGTGCTGGCTCACCTGGAGGCCGCCCGCACAGTGGCACACCACGGAGGCC
TGTACCACACCAATGCTGAAGTCAAGCTGCAGGGGTTCCAGGCCCGGCCGGAGCTCCTGGAGGTGTTCAGCACGGAGTTCCAGATGCGCC
TTCTCTGGGGCAGTCAGGGTGCCAGCAGCAGCCAGGCCCGGCGCTATGAGAAGTTCGACAAGGTCCTCACTGCCCTGTCCCACAAGCTGG
AACCTGCTGTCCGCTCCAGCGAGCTGTGACCCCAGGGACATTTCCCCTCTGCAGCTGCGGACAGCGTCAGGGGCAGAGGGGCACACAACT
TTCCCCAGAGCACCCCAAGGACACTGTGATCAACCCGAGAATGTTCTGGGTTCAACTCAAGCATCTCCCTTGCACCTCCAGGGTCCTGCG
TGGACTCTGGGTTCCATCCCACCTGCTACATGCTCACCAGGTCTCCATTGAGGAAGAACAGGAACGCCGGTTCCCCCACCAGCTTTTGCT
GCTCCCCTTCCTGCTGGGGTTCCCTGTTTTCGAGCCATGGGAGGCAGGCTGCTCACGCCTCCTCACTCTCTGTCTGTCCCTCACCAACAC
CAAGGCCTCCATCTCACTGTAAATAAGTCTCTGTTCTGTAAATAGATGTACAGAAGCCATGTTATTTCTTTCATATAATAAACTTTTATG
ACTCTTT

>9171_9171_6_BCAR3-SH2D3C_BCAR3_chr1_94057822_ENST00000370247_SH2D3C_chr9_130511944_ENST00000420366_length(amino acids)=703AA_BP=4
MPKECSAFHALSAALCCFYHRKSFIGVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSETLVQRNGDFLIRDSLT
SLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG
SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHA
APAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ
ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGV
TKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI
SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVA
HHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BCAR3-SH2D3C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for BCAR3-SH2D3C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for BCAR3-SH2D3C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBCAR3C0006142Malignant neoplasm of breast1CTD_human
HgeneBCAR3C0013146Drug abuse1CTD_human
HgeneBCAR3C0013170Drug habituation1CTD_human
HgeneBCAR3C0013222Drug Use Disorders1CTD_human
HgeneBCAR3C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneBCAR3C0038580Substance Dependence1CTD_human
HgeneBCAR3C0038586Substance Use Disorders1CTD_human
HgeneBCAR3C0236969Substance-Related Disorders1CTD_human
HgeneBCAR3C0678222Breast Carcinoma1CTD_human
HgeneBCAR3C0740858Substance abuse problem1CTD_human
HgeneBCAR3C1257931Mammary Neoplasms, Human1CTD_human
HgeneBCAR3C1458155Mammary Neoplasms1CTD_human
HgeneBCAR3C1510472Drug Dependence1CTD_human
HgeneBCAR3C4316881Prescription Drug Abuse1CTD_human
HgeneBCAR3C4704874Mammary Carcinoma, Human1CTD_human