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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARID5B-C10orf107 (FusionGDB2 ID:HG84159TG219621)

Fusion Gene Summary for ARID5B-C10orf107

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID5B-C10orf107
Fusion gene ID: hg84159tg219621
HgeneTgene
Gene symbol

ARID5B

C10orf107

Gene ID

84159

219621

Gene nameAT-rich interaction domain 5Bciliary associated calcium binding coiled-coil 1
SynonymsDESRT|MRF-2|MRF2C10orf107
Cytomap('ARID5B')('C10orf107')

10q21.2

10q21.2

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 5BARID domain-containing protein 5BAT-rich interactive domain 5B (MRF1-like)MRF1-like proteinmodulator recognition factor 2 (MRF2)ciliary-associated calcium-binding coiled-coil protein 1uncharacterized protein C10orf107
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000279873, ENST00000309334, 
Fusion gene scores* DoF score18 X 15 X 7=18902 X 3 X 2=12
# samples 183
** MAII scorelog2(18/1890*10)=-3.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARID5B [Title/Abstract] AND C10orf107 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARID5B(63662172)-C10orf107(63525697), # samples:1
Anticipated loss of major functional domain due to fusion event.ARID5B-C10orf107 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID5B-C10orf107 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARID5B

GO:0000122

negative regulation of transcription by RNA polymerase II

8649988

HgeneARID5B

GO:0051091

positive regulation of DNA-binding transcription factor activity

21532585


check buttonFusion gene breakpoints across ARID5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across C10orf107 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-3979-01AARID5Bchr10

63662172

+C10orf107chr10

63525697

+


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Fusion Gene ORF analysis for ARID5B-C10orf107

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000279873ENST00000330194ARID5Bchr10

63662172

+C10orf107chr10

63525697

+
intron-3CDSENST00000309334ENST00000330194ARID5Bchr10

63662172

+C10orf107chr10

63525697

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000279873ARID5Bchr1063662172+ENST00000330194C10orf107chr1063525697+1514686410760116

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000279873ENST00000330194ARID5Bchr1063662172+C10orf107chr1063525697+0.066959790.9330402

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Fusion Genomic Features for ARID5B-C10orf107


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARID5Bchr1063662172+C10orf107chr1063525696+0.58320360.41679642
ARID5Bchr1063662172+C10orf107chr1063525696+0.58320360.41679642

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARID5B-C10orf107


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:63662172/chr10:63525697)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID5Bchr10:63662172chr10:63525697ENST00000279873+210318_410921189.0DomainARID
HgeneARID5Bchr10:63662172chr10:63525697ENST00000309334+17318_4100946.0DomainARID


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Fusion Gene Sequence for ARID5B-C10orf107


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6499_6499_1_ARID5B-C10orf107_ARID5B_chr10_63662172_ENST00000279873_C10orf107_chr10_63525697_ENST00000330194_length(transcript)=1514nt_BP=686nt
ATCAGACGATATCCCAGACAGGAGCGGTTAGAGAGAGAGGAATCACATCTCCACACAGTTTTAGGGTGCTTTTTATTTTTACAAATCTTC
TTGTGTGTTTTTTGCCTTGATCCATCCTCTTCCCGCCGAGATCGTATGGCGCCTTTCTCTCGATTATGAATTTGATCAATCCATCTTTGG
AAGAAAACCCACATAGTTTTTTCAGGAGCTGAAAATTGAGTCGTTATAGAAATATTAGGACATATTTTCAATCATTTCGGTGCCCGAAGG
GAGGCAAGAGCTCAGTTTTATATTGAGACATTACGCCGGCTGAAGGCAGAGAATGCGTTTCCCTGCCAGGACCTGATGCAATCCATTCAA
GCCAACAAGTTTGGAGAGAATGTTGAGTTCAATCAATTCAGAACGTCGAGATGGAGCCCAACTCACTCCAGTGGGTCGGCTCACCGTGTG
GCTTGCACGGACCTTACATTTTCTACAAGGCTTTTCAATTCCACCTTGAAGGCAAACCAAGAATTTTGTCCCTTGGCGACTTTTTCTTTG
TAAGATGTACGCCAAAGGATCCGATTTGCATAGCGGAGCTCCAGCTGTTGTGGGAAGAGAGGACCAGCCGGCAACTTTTATCCAGCTCTA
AACTTTATTTCCTCCCAGAAGACACTCCCCAGGGCAGAAATAGCGACCATGGCGAGACCGAGATAAACGAAAAACTGCAAATACAGGAAG
AGGCCTTTAATGCACGAATAGAAAAATTGAAAAAGGCCTAAGGACTTGGTACAAGGAGAGTGATGCTAAACTTCACAGAAACAAACAAAA
CCAGCCAGAATAACAGACTCTCTGGAGCGTCGTGTCTCCATCACTTAGTTGTGAAAGGAAAACCAAGCCCCACTTTTTATTTTCCTAAGT
AATTAGAAAAGTATTGGTCCCAATTTTGCTATCTCCCATCCCATAACAGCCTCTGAATTTATTGCACCAAGTGTAATGAGAACATTTTGT
ATACAAGAGTTTGAAAAATTATATATAAAAATACAATTACTTTTATGATAGTCCTTTGACGTTTTGACTAATAAATCCTATTCATCTTCA
AGGAGAATGAAGTCAACTTTTTAAATAACCAGAAATAAAGAAAGATGATAATAACTTCATCCATTTTGACCCAAACGGACTGCCACGTTA
CTGGAACACTGTGAAAACATACCAGTACCACACTATTGAGGATAAAATTTGTTAAACAATAGCAATTCAAATGCATATATGAGGTTTTTT
TTTTTTTTACTGAAATCATTTGGTTTTCTTATTTAAACGTTTCAGTGTGAAACCAATTTTCTGAAATTATATAATGCAGTTTGAAGCACT
TTAATTTATTCTGTACTGTATTTGTTATTTCTAATCTTGTTACTCTCCCAGGAGAATACATGACCTATATAAAAAGAAGCAATGTATAAA

>6499_6499_1_ARID5B-C10orf107_ARID5B_chr10_63662172_ENST00000279873_C10orf107_chr10_63525697_ENST00000330194_length(amino acids)=116AA_BP=92
MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVRCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARID5B-C10orf107


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARID5B-C10orf107


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARID5B-C10orf107


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARID5BC0003873Rheumatoid Arthritis2CTD_human
HgeneARID5BC0023452Childhood Acute Lymphoblastic Leukemia2CTD_human
HgeneARID5BC0023453L2 Acute Lymphoblastic Leukemia2CTD_human
HgeneARID5BC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human
HgeneARID5BC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneARID5BC0013221Drug toxicity1CTD_human
HgeneARID5BC0018213Graves Disease1CTD_human
HgeneARID5BC0041755Adverse reaction to drug1CTD_human