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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ZCCHC7-ABCA6 (FusionGDB2 ID:HG84186TG23460) |
Fusion Gene Summary for ZCCHC7-ABCA6 |
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Fusion gene information | Fusion gene name: ZCCHC7-ABCA6 | Fusion gene ID: hg84186tg23460 | Hgene | Tgene | Gene symbol | ZCCHC7 | ABCA6 | Gene ID | 84186 | 23460 |
Gene name | zinc finger CCHC-type containing 7 | ATP binding cassette subfamily A member 6 | |
Synonyms | AIR1|HSPC086 | EST155051 | |
Cytomap | ('ZCCHC7')('ABCA6') 9p13.2 | 17q24.2-q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger CCHC domain-containing protein 7TRAMP-like complex RNA-binding factor ZCCHC7zinc finger, CCHC domain containing 7 | ATP-binding cassette sub-family A member 6ABC transporter ABCA6ATP-binding cassette A6ATP-binding cassette, sub-family A (ABC1), member 6 | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | Q8N3Z6 | Q8N139 | |
Ensembl transtripts involved in fusion gene | ENST00000461038, ENST00000322831, ENST00000336755, ENST00000534928, | ||
Fusion gene scores | * DoF score | 29 X 11 X 11=3509 | 4 X 4 X 3=48 |
# samples | 29 | 4 | |
** MAII score | log2(29/3509*10)=-3.59693514238723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZCCHC7 [Title/Abstract] AND ABCA6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ZCCHC7(37126939)-ABCA6(67136889), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | COAD | TCGA-A6-3810 | ZCCHC7 | chr9 | 37126939 | + | ABCA6 | chr17 | 67136889 | - |
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Fusion Gene ORF analysis for ZCCHC7-ABCA6 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-5UTR | ENST00000461038 | ENST00000284425 | ZCCHC7 | chr9 | 37126939 | + | ABCA6 | chr17 | 67136889 | - |
3UTR-5UTR | ENST00000461038 | ENST00000590645 | ZCCHC7 | chr9 | 37126939 | + | ABCA6 | chr17 | 67136889 | - |
3UTR-intron | ENST00000461038 | ENST00000446604 | ZCCHC7 | chr9 | 37126939 | + | ABCA6 | chr17 | 67136889 | - |
5CDS-5UTR | ENST00000322831 | ENST00000284425 | ZCCHC7 | chr9 | 37126939 | + | ABCA6 | chr17 | 67136889 | - |
5CDS-5UTR | ENST00000322831 | ENST00000590645 | ZCCHC7 | chr9 | 37126939 | + | ABCA6 | chr17 | 67136889 | - |
5CDS-5UTR | ENST00000336755 | ENST00000284425 | ZCCHC7 | chr9 | 37126939 | + | ABCA6 | chr17 | 67136889 | - |
5CDS-5UTR | ENST00000336755 | ENST00000590645 | ZCCHC7 | chr9 | 37126939 | + | ABCA6 | chr17 | 67136889 | - |
5CDS-intron | ENST00000322831 | ENST00000446604 | ZCCHC7 | chr9 | 37126939 | + | ABCA6 | chr17 | 67136889 | - |
5CDS-intron | ENST00000336755 | ENST00000446604 | ZCCHC7 | chr9 | 37126939 | + | ABCA6 | chr17 | 67136889 | - |
intron-5UTR | ENST00000534928 | ENST00000284425 | ZCCHC7 | chr9 | 37126939 | + | ABCA6 | chr17 | 67136889 | - |
intron-5UTR | ENST00000534928 | ENST00000590645 | ZCCHC7 | chr9 | 37126939 | + | ABCA6 | chr17 | 67136889 | - |
intron-intron | ENST00000534928 | ENST00000446604 | ZCCHC7 | chr9 | 37126939 | + | ABCA6 | chr17 | 67136889 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ZCCHC7-ABCA6 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ZCCHC7-ABCA6 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:37126939/:67136889) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ZCCHC7 | ABCA6 |
FUNCTION: Probable transporter which may play a role in macrophage lipid transport and homeostasis. {ECO:0000305|PubMed:10639163}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ZCCHC7-ABCA6 |
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Fusion Gene PPI Analysis for ZCCHC7-ABCA6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ZCCHC7-ABCA6 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ZCCHC7-ABCA6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0009402 | Colorectal Carcinoma | 1 | CTD_human | |
Tgene | C0009404 | Colorectal Neoplasms | 1 | CTD_human | |
Tgene | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |