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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:METTL25-ATP2B1 (FusionGDB2 ID:HG84190TG490)

Fusion Gene Summary for METTL25-ATP2B1

check button Fusion gene summary
Fusion gene informationFusion gene name: METTL25-ATP2B1
Fusion gene ID: hg84190tg490
HgeneTgene
Gene symbol

METTL25

ATP2B1

Gene ID

84190

490

Gene namemethyltransferase like 25ATPase plasma membrane Ca2+ transporting 1
SynonymsC12orf26PMCA1|PMCA1kb
Cytomap('C12orf26','METTL25')('ATP2B1','ATP2B1')

12q21.31

12q21.33

Type of geneprotein-codingprotein-coding
Descriptionmethyltransferase-like protein 25plasma membrane calcium-transporting ATPase 1ATPase, Ca++ transporting, plasma membrane 1plasma membrane calcium pump
Modification date2020032020200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000547357, ENST00000248306, 
Fusion gene scores* DoF score6 X 5 X 2=607 X 7 X 4=196
# samples 67
** MAII scorelog2(6/60*10)=0log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: METTL25 [Title/Abstract] AND ATP2B1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC12orf26(82793173)-ATP2B1(90005149), # samples:2
METTL25(82793173)-ATP2B1(90005149), # samples:1
Anticipated loss of major functional domain due to fusion event.METTL25-ATP2B1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
METTL25-ATP2B1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
METTL25-ATP2B1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
METTL25-ATP2B1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATP2B1

GO:0051480

regulation of cytosolic calcium ion concentration

18029012

TgeneATP2B1

GO:1990034

calcium ion export across plasma membrane

18029012


check buttonFusion gene breakpoints across METTL25 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ATP2B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A48N-01AC12orf26chr12

82793173

-ATP2B1chr12

90005149

-
ChimerDB4SARCTCGA-DX-A48N-01AMETTL25chr12

82793173

+ATP2B1chr12

90005149

-
ChimerDB4SARCTCGA-DX-A48NC12orf26chr12

82793173

+ATP2B1chr12

90005149

-


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Fusion Gene ORF analysis for METTL25-ATP2B1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000547357ENST00000261173METTL25chr12

82793173

+ATP2B1chr12

90005149

-
3UTR-3CDSENST00000547357ENST00000348959METTL25chr12

82793173

+ATP2B1chr12

90005149

-
3UTR-3CDSENST00000547357ENST00000359142METTL25chr12

82793173

+ATP2B1chr12

90005149

-
3UTR-3CDSENST00000547357ENST00000393164METTL25chr12

82793173

+ATP2B1chr12

90005149

-
3UTR-3CDSENST00000547357ENST00000428670METTL25chr12

82793173

+ATP2B1chr12

90005149

-
In-frameENST00000248306ENST00000261173METTL25chr12

82793173

+ATP2B1chr12

90005149

-
In-frameENST00000248306ENST00000348959METTL25chr12

82793173

+ATP2B1chr12

90005149

-
In-frameENST00000248306ENST00000359142METTL25chr12

82793173

+ATP2B1chr12

90005149

-
In-frameENST00000248306ENST00000393164METTL25chr12

82793173

+ATP2B1chr12

90005149

-
In-frameENST00000248306ENST00000428670METTL25chr12

82793173

+ATP2B1chr12

90005149

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000248306METTL25chr1282793173+ENST00000348959ATP2B1chr1290005149-5621120062687893
ENST00000248306METTL25chr1282793173+ENST00000261173ATP2B1chr1290005149-5729120062795929
ENST00000248306METTL25chr1282793173+ENST00000359142ATP2B1chr1290005149-5878120062663885
ENST00000248306METTL25chr1282793173+ENST00000428670ATP2B1chr1290005149-5708120062795929
ENST00000248306METTL25chr1282793173+ENST00000393164ATP2B1chr1290005149-2938120062795929

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000248306ENST00000348959METTL25chr1282793173+ATP2B1chr1290005149-0.0001252350.9998747
ENST00000248306ENST00000261173METTL25chr1282793173+ATP2B1chr1290005149-0.0001057830.99989426
ENST00000248306ENST00000359142METTL25chr1282793173+ATP2B1chr1290005149-0.0001325050.99986744
ENST00000248306ENST00000428670METTL25chr1282793173+ATP2B1chr1290005149-0.0001071920.99989283
ENST00000248306ENST00000393164METTL25chr1282793173+ATP2B1chr1290005149-0.0003166680.9996834

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Fusion Genomic Features for METTL25-ATP2B1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for METTL25-ATP2B1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:82793173/chr12:90005149)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATP2B1chr12:82793173chr12:90005149ENST0000026117310201100_11176891221.0RegionCalmodulin-binding subdomain A
TgeneATP2B1chr12:82793173chr12:90005149ENST0000026117310201118_12206891221.0RegionRequired for basolateral membrane targeting
TgeneATP2B1chr12:82793173chr12:90005149ENST0000034895910191100_11176891185.0RegionCalmodulin-binding subdomain A
TgeneATP2B1chr12:82793173chr12:90005149ENST0000034895910191118_12206891185.0RegionRequired for basolateral membrane targeting
TgeneATP2B1chr12:82793173chr12:90005149ENST0000035914210211100_11176891177.0RegionCalmodulin-binding subdomain A
TgeneATP2B1chr12:82793173chr12:90005149ENST0000035914210211118_12206891177.0RegionRequired for basolateral membrane targeting
TgeneATP2B1chr12:82793173chr12:90005149ENST0000042867011211100_11176891221.0RegionCalmodulin-binding subdomain A
TgeneATP2B1chr12:82793173chr12:90005149ENST0000042867011211118_12206891221.0RegionRequired for basolateral membrane targeting
TgeneATP2B1chr12:82793173chr12:90005149ENST0000026117310201028_10396891221.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST0000026117310201061_12206891221.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020877_8826891221.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020904_9276891221.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020949_9716891221.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020992_10056891221.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST0000034895910191028_10396891185.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST0000034895910191061_12206891185.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019877_8826891185.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019904_9276891185.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019949_9716891185.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019992_10056891185.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST0000035914210211028_10396891177.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST0000035914210211061_12206891177.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021877_8826891177.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021904_9276891177.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021949_9716891177.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021992_10056891177.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST0000042867011211028_10396891221.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST0000042867011211061_12206891221.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121877_8826891221.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121904_9276891221.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121949_9716891221.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121992_10056891221.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST0000026117310201006_10276891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST0000026117310201040_10606891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020856_8766891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020883_9036891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020928_9486891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020972_9916891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST0000034895910191006_10276891185.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST0000034895910191040_10606891185.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019856_8766891185.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019883_9036891185.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019928_9486891185.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019972_9916891185.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST0000035914210211006_10276891177.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST0000035914210211040_10606891177.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021856_8766891177.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021883_9036891177.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021928_9486891177.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021972_9916891177.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST0000042867011211006_10276891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST0000042867011211040_10606891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121856_8766891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121883_9036891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121928_9486891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121972_9916891221.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020296_2996891221.0Compositional biasNote=Poly-Glu
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019296_2996891185.0Compositional biasNote=Poly-Glu
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021296_2996891177.0Compositional biasNote=Poly-Glu
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121296_2996891221.0Compositional biasNote=Poly-Glu
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020127_1546891221.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020176_3666891221.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST0000026117310202_1056891221.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020387_4186891221.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020440_8556891221.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019127_1546891185.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019176_3666891185.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST0000034895910192_1056891185.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019387_4186891185.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019440_8556891185.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021127_1546891177.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021176_3666891177.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST0000035914210212_1056891177.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021387_4186891177.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021440_8556891177.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121127_1546891221.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121176_3666891221.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST0000042867011212_1056891221.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121387_4186891221.0Topological domainExtracellular
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121440_8556891221.0Topological domainCytoplasmic
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020106_1266891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020155_1756891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020367_3866891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000002611731020419_4396891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019106_1266891185.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019155_1756891185.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019367_3866891185.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003489591019419_4396891185.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021106_1266891177.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021155_1756891177.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021367_3866891177.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000003591421021419_4396891177.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121106_1266891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121155_1756891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121367_3866891221.0TransmembraneHelical
TgeneATP2B1chr12:82793173chr12:90005149ENST000004286701121419_4396891221.0TransmembraneHelical


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Fusion Gene Sequence for METTL25-ATP2B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>53111_53111_1_METTL25-ATP2B1_METTL25_chr12_82793173_ENST00000248306_ATP2B1_chr12_90005149_ENST00000261173_length(transcript)=5729nt_BP=1200nt
GCTAATTTGGGCCGAGCTGGCGCCTCACGGCCATGTTTGCGCCACCTACAGCCTCGGAGGGTGAGCGTCATGGCGGCTTCTTGCCCTCTC
CCGGTGACCCCGGACCTGCCCACGCTGCGTGCCAAGTTGCAGGGACTGCTGCAGTTCCTGAGGGATGCCCTGTCCATTTCCAATGCACAT
ACCGTGGATTTCTACACAGAATCCGTGTGGGAGGAGCTGGTCGACTTGCCACCGGAGACAGTGCTGGCTGCGCTGAGGAAGTCAGCGTCG
GAGACGGAGGCCCTGCCCTCAGAGACGCGCCCCCTAGTGGAAGCAGAGTGGGAAGCAGGTATGACTGATTTTCCCAAAATATTTTGTGAA
ACTTCTCAGAAGTTGGTGAGTGTGGAAGCCTTTGCTCTGGCTGCGAAATACTATTCTGTACAAAACTTGGGAATATGTACTCCTTTTGAA
CAGTTGCTTGTAGCCCTTCGAGGAAATCAAAACCAGAGAATTGGTGAAAATCAGAAGGCAGTTGAGTTTATGAATATGAAGAAATCTCAT
GAAGTTCAGGCAATGTCAGAGCTGATCAGCAGTATTGCTGACTACTATGGAATAAAGCAGGTGATTGACTTGGGTTCCGGTAAAGGCTAC
CTAAGCTCTTTTTTGTCCTTGAAGTATGGCTTAAAAGTTTATGGAATTGATTCTTCAAATACCAATACTCATGGAGCTGAGGAGAGAAAC
AGAAAATTGAAGAAACATTGGAAACTCTGTCATGCTCAGTCAAGATTAGATGTCAATGGACTAGCATTAAAAATGGCAAAAGAAAGGAAA
GTGCAAAATAAAGTTAAAAATAAAGCTGATACTGAGGAAGTGTTTAACAACAGTCCTACAAATCAAGAAAAGATGCCTACCTCAGCTATT
TTGCCTGATTTTTCTGGCTCTGTAATTTCTAATATCAGAAACCAAATGGAAACCCTTCATTCTCAGCCACATCAAGAAGAAAATTTGTGT
TTTGAAAATTCCTTTTCTCTTATAAACCTTTTGCCTATTAATGCTGTAGAGCCTACTTCTTCACAGCAAATACCCAACAGAGAAACATCT
GAAGCCAATAAAGAGAGAAGAAAAATGACATCAAAGTCAAGTGAATCAAATATATATTCACCTTTAACCTCTTTTATCACTGCTGATTCA
GAACTCCATGACATTATTAAAGATTTGGAGGTGCCAGATGCAATTAAAAAGTGTCAGAGGGCTGGAATTACTGTGCGGATGGTCACTGGT
GATAATATTAATACTGCTCGGGCCATTGCTACCAAATGTGGTATTTTACATCCTGGGGAAGATTTTCTGTGCCTAGAAGGTAAAGATTTT
AACAGAAGAATACGAAATGAAAAAGGAGAGATTGAGCAAGAGAGGATAGACAAGATTTGGCCAAAACTTCGAGTACTTGCAAGATCATCT
CCTACTGATAAGCATACACTGGTTAAAGGTATAATTGACAGCACTGTCTCAGACCAACGCCAGGTTGTAGCTGTAACTGGTGATGGTACA
AATGATGGCCCAGCACTAAAGAAAGCAGATGTTGGATTTGCAATGGGTATTGCTGGAACTGATGTAGCTAAAGAAGCATCCGATATTATT
CTCACAGATGACAACTTTACAAGCATTGTTAAAGCAGTTATGTGGGGACGAAATGTCTATGACAGCATCTCAAAATTCCTTCAGTTCCAA
CTTACTGTTAATGTAGTAGCAGTGATTGTTGCTTTTACGGGCGCCTGCATTACTCAAGACTCACCGCTTAAGGCTGTGCAGATGCTGTGG
GTAAACCTCATAATGGATACACTCGCTTCCCTGGCTCTGGCAACGGAACCACCCACTGAGTCTCTCTTGCTTCGGAAACCTTATGGTAGA
AATAAGCCTCTCATCTCACGTACAATGATGAAGAATATTTTGGGTCATGCATTCTATCAACTTGTAGTAGTCTTTACACTCTTATTTGCT
GGAGAAAAGTTTTTTGACATTGATAGTGGAAGAAATGCTCCTTTGCATGCTCCTCCTTCAGAACATTATACTATTGTTTTTAATACCTTT
GTGCTGATGCAACTTTTCAACGAAATAAATGCCCGGAAAATTCATGGTGAAAGAAATGTATTCGAAGGAATCTTTAACAATGCCATCTTC
TGCACAATTGTTTTAGGCACTTTTGTGGTACAGATAATAATTGTGCAGTTTGGTGGAAAACCTTTCAGTTGTTCAGAACTTTCAATAGAA
CAGTGGCTATGGTCAATATTCCTAGGAATGGGAACATTACTCTGGGGCCAGCTTATTTCAACAATTCCAACTAGCCGTTTAAAATTCCTC
AAAGAAGCTGGTCATGGAACACAAAAGGAAGAAATACCTGAGGAGGAATTAGCAGAGGATGTTGAAGAGATTGATCACGCTGAAAGGGAG
TTGCGGCGTGGCCAAATCTTGTGGTTTAGAGGTCTGAACAGAATCCAAACACAGATTCGAGTGGTGAATGCATTTCGTAGTTCTTTATAT
GAAGGGTTAGAAAAACCGGAATCAAGAAGTTCGATTCACAACTTTATGACACATCCTGAGTTTAGGATAGAAGATTCAGAGCCTCATATC
CCCCTTATTGATGACACTGATGCCGAAGATGATGCTCCTACAAAACGTAACTCCAGTCCTCCACCCTCTCCCAACAAAAATAACAATGCT
GTTGACAGTGGAATTCACCTTACAATAGAAATGAACAAGTCTGCTACCTCTTCATCCCCAGGAAGCCCACTACATAGTTTGGAAACATCA
CTCTGATTGTAAGCTGAATGTTAACACACTAGCTGCATTGTAAAGAAACAAATTGAAACTGGGTCTTTTCACATATTGTGATGGACAAGC
TAGTATTCTTGTCTTTGGACTTCAACAGAAGACACACTTGTACGAATGTAGATTTATTTTTTTAAAAAAAAAAAAGCAAAGCTTTCTGCC
AGACTGAGGGTGCTTTTTGGGGGGTGGGAGAAATGAACTGACAGATAAACAGTAACTCAGCGTAAGTGACCTGTGGATCATCAGTAGTAC
CCAAGCATGGTCCTGAACAGTGTATTAGCAGAGCTTTAGTTTATCTCAGTCCTGGATGGGAGAGAGAGGGAGGAGTAAAACTGGGCAAGA
CAAAGAGCCCTGGATCGTTGAATTGATAGTTTAATTTCTGCTGTTGGCTGTTAATAATTTGGATTATTTATGTTTATAAATGATACAGAT
CTGTTTACAAGGTTTGTAGATACTTTTTTTGTTCCTGTTCATAGATGGGAAGCTTCCTTATAACTGATGCAGAGAAAAATTAGTCCTTCA
AATACTGCTGTATTTTCAGGAAAAAAAAAAAAAGGGGTGTTTCTATTGAAACTGTACTAAATTTTTGCCTACAATTTACCTTGTTAAATA
TTGTAGATAAATTGCTAATACTAATAGCCAAATAGATAACACTAATGCTTTGTTTAAAAAAACGAAAAAAACAAAACAAAACAAAAAAAC
ATGAGCAGTGGTGTTCTAATGAAGTTATGACATCTGTCCTAATTAGTTTCTTAAATACATTTACTACTTAATGGTTTTGAAGCAACTGTT
TAATTTTTAAAATTTTTGAAAACTTGCTAATAACCTTTTGTTCAGAATTTAGTAGATTGTTTAATGCAGGACATCAACTACATAATGAAA
GATGCTTGAAATGCTTTTGTTATTTCAGGCAAATCAAATTAAATCAGACTATCAAACTACAAGAGAACCTTAGTCTTTTTTGTTTTTGTC
TAAACATGTTAGTTTAGTGATGTCTTGGTGAACTGTGAGTGAACTGTATTGATTTTTCTAATCTTTAGAGACCTTCACACAGCATGAGGG
CTGTTGGCATTTTGAAAAAGGTTAATAAGTAGAAGCATACATGTTTTCCTTTTGTTTTTGAAACTTGTTTGTAAACATAAATAAATATGC
CCTTTTATTAAATAAATTCATGGCAATGTTTTTTTAAAAGACATTTCAGCTTCTTTACTCAGTTCTGCATATACAGTGCATCAGTCTGTT
CTCTTTGACCACAATTGGAATACATTTCAAGATGGTAACAGCCCCATGAAGTACCGCTTTAATTCCTTGCTGGTAATCTAATAGAATCAG
ATTAAGAAAATTAACACAATTTTACCATTTGACATACTCTTCATTGAATTTAGTTTGTCTAAAATAGTCTCACAGGTAAAAAACATAACA
ACAATGACCACCATTGTCTTTGATACATTTATTTTAATTCTTAAGTGGCCAAATAACAGATTAGGTAAAATGAGATTACATGAAAAGGTT
CTAAAATGATATATTTAGATGCAATAATTAACCATATGCTAGAATGCCCACCTCTAAGCCAATTGGATTCTTTAGCTCTCTTTTTCTTTC
CTTCATCTACCTTCTTCTCTTTTTTGCCTCTGTCTTTACCCTTTAGAAACTGGCATGTGTTAGGGCCCAGATTTCACCAGATACACAATC
CTCAGGCTGACATAAAGTTTACGAGGACTGCTACTATAACTGAGAGTGCTGACCAAGCAAAGAAACATTTAGTTGATGGTGCTTGATATT
TTTGGTGGGTGGGGGAAATCTTTTTCTCACCATCAAATCTTTGCAGTAATCCTCTGCAGGTCTTAGAAACACATTGGCTCTGTCAGCATT
TGTAATTGTACATTTATTCATCAGGTATTTATAGTGAATCATACTGTAAAAAAGAGGTAGCATGATATGCTGGAAAGCATATTAGACTAG
GAGTCAAGACCTGGTTTCTAGTCTTGGTTTTGCCATTAATGTGCTGCATGATCTTGGGAAAATCATTTACCCTAAATAAGGGTGGTGGAC
TATCTTGAAGAACCCTTTCAACTCTAAAAATTGACCCTATCAACTGGAGAGCCCACAAGGCATAGGGAATAGAGAAAAGGGAAATGTTTT
CAGTTTTCTTTTTTATTTTGGTTATGCTTAAATATGAATGTAATTACCAAAAGATTTAGAAGTGCATGTGCTTTGGAGGATTTGTATTGA
GCTTTTACAGTATTCATTTTTCAACTCAAGGCAATGGCTTTCTACACCAACTCTAATCCATAAACGGGTCTTATGACATCTATGAAGTAG
TAGCAAGACATGCTTAGTGTGTATTTCTCTCTTTGAGACACTGTAATTTCTACCAGAAATTTCCAGAGCATTATGTAGGTAGAAAAAAAT
GCAAGCAAGCTGTTAAAGATCTTGGATCCCATTATATAGTATGTATAGCTGAAATCTGTAATTCAATCACTTTTTCTCTTTTATCCTCTA
ACCAAAAAATTGTTTAATTTTGCATCCCAAATGTTTTTAATCTTTGTATATTTTTTAAAAATCCTTTTCTCCTCATCATTGCCTTTTTTG
TGGTTGTAAATAGACTTACTTGCACTTTGAAGATGAGTTACTCCTTGTCATCTTACAAATATGTGATATGGTAATTTTCATAACAGATGT
CAGTTTTGAACCAAGAATTGGTGATTTGTTTATAAGAAAAAAACTGGCTTCATTTCTGTGAAATTGCTCTTTGAAAATTTCTTTTTACAC
GTGTAAGCCAACTGAGATACCGTGATGGTGTTGATTTCTTTCAATGATGCTTACCATCTATTTTAGCCACTGAGCCTTTTATTATTTGTC
TATTTGTAAAGTTTATTTGTCTTAACTCATTTAATAAATATACTGTTTATCTGTTTCTG

>53111_53111_1_METTL25-ATP2B1_METTL25_chr12_82793173_ENST00000248306_ATP2B1_chr12_90005149_ENST00000261173_length(amino acids)=929AA_BP=398
MGRAGASRPCLRHLQPRRVSVMAASCPLPVTPDLPTLRAKLQGLLQFLRDALSISNAHTVDFYTESVWEELVDLPPETVLAALRKSASET
EALPSETRPLVEAEWEAGMTDFPKIFCETSQKLVSVEAFALAAKYYSVQNLGICTPFEQLLVALRGNQNQRIGENQKAVEFMNMKKSHEV
QAMSELISSIADYYGIKQVIDLGSGKGYLSSFLSLKYGLKVYGIDSSNTNTHGAEERNRKLKKHWKLCHAQSRLDVNGLALKMAKERKVQ
NKVKNKADTEEVFNNSPTNQEKMPTSAILPDFSGSVISNIRNQMETLHSQPHQEENLCFENSFSLINLLPINAVEPTSSQQIPNRETSEA
NKERRKMTSKSSESNIYSPLTSFITADSELHDIIKDLEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNR
RIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILT
DDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNK
PLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCT
IVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELR
RGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVD
SGIHLTIEMNKSATSSSPGSPLHSLETSL

--------------------------------------------------------------
>53111_53111_2_METTL25-ATP2B1_METTL25_chr12_82793173_ENST00000248306_ATP2B1_chr12_90005149_ENST00000348959_length(transcript)=5621nt_BP=1200nt
GCTAATTTGGGCCGAGCTGGCGCCTCACGGCCATGTTTGCGCCACCTACAGCCTCGGAGGGTGAGCGTCATGGCGGCTTCTTGCCCTCTC
CCGGTGACCCCGGACCTGCCCACGCTGCGTGCCAAGTTGCAGGGACTGCTGCAGTTCCTGAGGGATGCCCTGTCCATTTCCAATGCACAT
ACCGTGGATTTCTACACAGAATCCGTGTGGGAGGAGCTGGTCGACTTGCCACCGGAGACAGTGCTGGCTGCGCTGAGGAAGTCAGCGTCG
GAGACGGAGGCCCTGCCCTCAGAGACGCGCCCCCTAGTGGAAGCAGAGTGGGAAGCAGGTATGACTGATTTTCCCAAAATATTTTGTGAA
ACTTCTCAGAAGTTGGTGAGTGTGGAAGCCTTTGCTCTGGCTGCGAAATACTATTCTGTACAAAACTTGGGAATATGTACTCCTTTTGAA
CAGTTGCTTGTAGCCCTTCGAGGAAATCAAAACCAGAGAATTGGTGAAAATCAGAAGGCAGTTGAGTTTATGAATATGAAGAAATCTCAT
GAAGTTCAGGCAATGTCAGAGCTGATCAGCAGTATTGCTGACTACTATGGAATAAAGCAGGTGATTGACTTGGGTTCCGGTAAAGGCTAC
CTAAGCTCTTTTTTGTCCTTGAAGTATGGCTTAAAAGTTTATGGAATTGATTCTTCAAATACCAATACTCATGGAGCTGAGGAGAGAAAC
AGAAAATTGAAGAAACATTGGAAACTCTGTCATGCTCAGTCAAGATTAGATGTCAATGGACTAGCATTAAAAATGGCAAAAGAAAGGAAA
GTGCAAAATAAAGTTAAAAATAAAGCTGATACTGAGGAAGTGTTTAACAACAGTCCTACAAATCAAGAAAAGATGCCTACCTCAGCTATT
TTGCCTGATTTTTCTGGCTCTGTAATTTCTAATATCAGAAACCAAATGGAAACCCTTCATTCTCAGCCACATCAAGAAGAAAATTTGTGT
TTTGAAAATTCCTTTTCTCTTATAAACCTTTTGCCTATTAATGCTGTAGAGCCTACTTCTTCACAGCAAATACCCAACAGAGAAACATCT
GAAGCCAATAAAGAGAGAAGAAAAATGACATCAAAGTCAAGTGAATCAAATATATATTCACCTTTAACCTCTTTTATCACTGCTGATTCA
GAACTCCATGACATTATTAAAGATTTGGAGGTGCCAGATGCAATTAAAAAGTGTCAGAGGGCTGGAATTACTGTGCGGATGGTCACTGGT
GATAATATTAATACTGCTCGGGCCATTGCTACCAAATGTGGTATTTTACATCCTGGGGAAGATTTTCTGTGCCTAGAAGGTAAAGATTTT
AACAGAAGAATACGAAATGAAAAAGGAGAGATTGAGCAAGAGAGGATAGACAAGATTTGGCCAAAACTTCGAGTACTTGCAAGATCATCT
CCTACTGATAAGCATACACTGGTTAAAGGTATAATTGACAGCACTGTCTCAGACCAACGCCAGGTTGTAGCTGTAACTGGTGATGGTACA
AATGATGGCCCAGCACTAAAGAAAGCAGATGTTGGATTTGCAATGGGTATTGCTGGAACTGATGTAGCTAAAGAAGCATCCGATATTATT
CTCACAGATGACAACTTTACAAGCATTGTTAAAGCAGTTATGTGGGGACGAAATGTCTATGACAGCATCTCAAAATTCCTTCAGTTCCAA
CTTACTGTTAATGTAGTAGCAGTGATTGTTGCTTTTACGGGCGCCTGCATTACTCAAGACTCACCGCTTAAGGCTGTGCAGATGCTGTGG
GTAAACCTCATAATGGATACACTCGCTTCCCTGGCTCTGGCAACGGAACCACCCACTGAGTCTCTCTTGCTTCGGAAACCTTATGGTAGA
AATAAGCCTCTCATCTCACGTACAATGATGAAGAATATTTTGGGTCATGCATTCTATCAACTTGTAGTAGTCTTTACACTCTTATTTGCT
GGAGAAAAGTTTTTTGACATTGATAGTGGAAGAAATGCTCCTTTGCATGCTCCTCCTTCAGAACATTATACTATTGTTTTTAATACCTTT
GTGCTGATGCAACTTTTCAACGAAATAAATGCCCGGAAAATTCATGGTGAAAGAAATGTATTCGAAGGAATCTTTAACAATGCCATCTTC
TGCACAATTGTTTTAGGCACTTTTGTGGTACAGCTTATTTCAACAATTCCAACTAGCCGTTTAAAATTCCTCAAAGAAGCTGGTCATGGA
ACACAAAAGGAAGAAATACCTGAGGAGGAATTAGCAGAGGATGTTGAAGAGATTGATCACGCTGAAAGGGAGTTGCGGCGTGGCCAAATC
TTGTGGTTTAGAGGTCTGAACAGAATCCAAACACAGATTCGAGTGGTGAATGCATTTCGTAGTTCTTTATATGAAGGGTTAGAAAAACCG
GAATCAAGAAGTTCGATTCACAACTTTATGACACATCCTGAGTTTAGGATAGAAGATTCAGAGCCTCATATCCCCCTTATTGATGACACT
GATGCCGAAGATGATGCTCCTACAAAACGTAACTCCAGTCCTCCACCCTCTCCCAACAAAAATAACAATGCTGTTGACAGTGGAATTCAC
CTTACAATAGAAATGAACAAGTCTGCTACCTCTTCATCCCCAGGAAGCCCACTACATAGTTTGGAAACATCACTCTGATTGTAAGCTGAA
TGTTAACACACTAGCTGCATTGTAAAGAAACAAATTGAAACTGGGTCTTTTCACATATTGTGATGGACAAGCTAGTATTCTTGTCTTTGG
ACTTCAACAGAAGACACACTTGTACGAATGTAGATTTATTTTTTTAAAAAAAAAAAAGCAAAGCTTTCTGCCAGACTGAGGGTGCTTTTT
GGGGGGTGGGAGAAATGAACTGACAGATAAACAGTAACTCAGCGTAAGTGACCTGTGGATCATCAGTAGTACCCAAGCATGGTCCTGAAC
AGTGTATTAGCAGAGCTTTAGTTTATCTCAGTCCTGGATGGGAGAGAGAGGGAGGAGTAAAACTGGGCAAGACAAAGAGCCCTGGATCGT
TGAATTGATAGTTTAATTTCTGCTGTTGGCTGTTAATAATTTGGATTATTTATGTTTATAAATGATACAGATCTGTTTACAAGGTTTGTA
GATACTTTTTTTGTTCCTGTTCATAGATGGGAAGCTTCCTTATAACTGATGCAGAGAAAAATTAGTCCTTCAAATACTGCTGTATTTTCA
GGAAAAAAAAAAAAAGGGGTGTTTCTATTGAAACTGTACTAAATTTTTGCCTACAATTTACCTTGTTAAATATTGTAGATAAATTGCTAA
TACTAATAGCCAAATAGATAACACTAATGCTTTGTTTAAAAAAACGAAAAAAACAAAACAAAACAAAAAAACATGAGCAGTGGTGTTCTA
ATGAAGTTATGACATCTGTCCTAATTAGTTTCTTAAATACATTTACTACTTAATGGTTTTGAAGCAACTGTTTAATTTTTAAAATTTTTG
AAAACTTGCTAATAACCTTTTGTTCAGAATTTAGTAGATTGTTTAATGCAGGACATCAACTACATAATGAAAGATGCTTGAAATGCTTTT
GTTATTTCAGGCAAATCAAATTAAATCAGACTATCAAACTACAAGAGAACCTTAGTCTTTTTTGTTTTTGTCTAAACATGTTAGTTTAGT
GATGTCTTGGTGAACTGTGAGTGAACTGTATTGATTTTTCTAATCTTTAGAGACCTTCACACAGCATGAGGGCTGTTGGCATTTTGAAAA
AGGTTAATAAGTAGAAGCATACATGTTTTCCTTTTGTTTTTGAAACTTGTTTGTAAACATAAATAAATATGCCCTTTTATTAAATAAATT
CATGGCAATGTTTTTTTAAAAGACATTTCAGCTTCTTTACTCAGTTCTGCATATACAGTGCATCAGTCTGTTCTCTTTGACCACAATTGG
AATACATTTCAAGATGGTAACAGCCCCATGAAGTACCGCTTTAATTCCTTGCTGGTAATCTAATAGAATCAGATTAAGAAAATTAACACA
ATTTTACCATTTGACATACTCTTCATTGAATTTAGTTTGTCTAAAATAGTCTCACAGGTAAAAAACATAACAACAATGACCACCATTGTC
TTTGATACATTTATTTTAATTCTTAAGTGGCCAAATAACAGATTAGGTAAAATGAGATTACATGAAAAGGTTCTAAAATGATATATTTAG
ATGCAATAATTAACCATATGCTAGAATGCCCACCTCTAAGCCAATTGGATTCTTTAGCTCTCTTTTTCTTTCCTTCATCTACCTTCTTCT
CTTTTTTGCCTCTGTCTTTACCCTTTAGAAACTGGCATGTGTTAGGGCCCAGATTTCACCAGATACACAATCCTCAGGCTGACATAAAGT
TTACGAGGACTGCTACTATAACTGAGAGTGCTGACCAAGCAAAGAAACATTTAGTTGATGGTGCTTGATATTTTTGGTGGGTGGGGGAAA
TCTTTTTCTCACCATCAAATCTTTGCAGTAATCCTCTGCAGGTCTTAGAAACACATTGGCTCTGTCAGCATTTGTAATTGTACATTTATT
CATCAGGTATTTATAGTGAATCATACTGTAAAAAAGAGGTAGCATGATATGCTGGAAAGCATATTAGACTAGGAGTCAAGACCTGGTTTC
TAGTCTTGGTTTTGCCATTAATGTGCTGCATGATCTTGGGAAAATCATTTACCCTAAATAAGGGTGGTGGACTATCTTGAAGAACCCTTT
CAACTCTAAAAATTGACCCTATCAACTGGAGAGCCCACAAGGCATAGGGAATAGAGAAAAGGGAAATGTTTTCAGTTTTCTTTTTTATTT
TGGTTATGCTTAAATATGAATGTAATTACCAAAAGATTTAGAAGTGCATGTGCTTTGGAGGATTTGTATTGAGCTTTTACAGTATTCATT
TTTCAACTCAAGGCAATGGCTTTCTACACCAACTCTAATCCATAAACGGGTCTTATGACATCTATGAAGTAGTAGCAAGACATGCTTAGT
GTGTATTTCTCTCTTTGAGACACTGTAATTTCTACCAGAAATTTCCAGAGCATTATGTAGGTAGAAAAAAATGCAAGCAAGCTGTTAAAG
ATCTTGGATCCCATTATATAGTATGTATAGCTGAAATCTGTAATTCAATCACTTTTTCTCTTTTATCCTCTAACCAAAAAATTGTTTAAT
TTTGCATCCCAAATGTTTTTAATCTTTGTATATTTTTTAAAAATCCTTTTCTCCTCATCATTGCCTTTTTTGTGGTTGTAAATAGACTTA
CTTGCACTTTGAAGATGAGTTACTCCTTGTCATCTTACAAATATGTGATATGGTAATTTTCATAACAGATGTCAGTTTTGAACCAAGAAT
TGGTGATTTGTTTATAAGAAAAAAACTGGCTTCATTTCTGTGAAATTGCTCTTTGAAAATTTCTTTTTACACGTGTAAGCCAACTGAGAT
ACCGTGATGGTGTTGATTTCTTTCAATGATGCTTACCATCTATTTTAGCCACTGAGCCTTTTATTATTTGTCTATTTGTAAAGTTTATTT
GTCTTAACTCATTTAATAAATATACTGTTTATCTGTTTCTG

>53111_53111_2_METTL25-ATP2B1_METTL25_chr12_82793173_ENST00000248306_ATP2B1_chr12_90005149_ENST00000348959_length(amino acids)=893AA_BP=398
MGRAGASRPCLRHLQPRRVSVMAASCPLPVTPDLPTLRAKLQGLLQFLRDALSISNAHTVDFYTESVWEELVDLPPETVLAALRKSASET
EALPSETRPLVEAEWEAGMTDFPKIFCETSQKLVSVEAFALAAKYYSVQNLGICTPFEQLLVALRGNQNQRIGENQKAVEFMNMKKSHEV
QAMSELISSIADYYGIKQVIDLGSGKGYLSSFLSLKYGLKVYGIDSSNTNTHGAEERNRKLKKHWKLCHAQSRLDVNGLALKMAKERKVQ
NKVKNKADTEEVFNNSPTNQEKMPTSAILPDFSGSVISNIRNQMETLHSQPHQEENLCFENSFSLINLLPINAVEPTSSQQIPNRETSEA
NKERRKMTSKSSESNIYSPLTSFITADSELHDIIKDLEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNR
RIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILT
DDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNK
PLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCT
IVLGTFVVQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPES
RSSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEMNKSATSSSPGSPLHSLETSL

--------------------------------------------------------------
>53111_53111_3_METTL25-ATP2B1_METTL25_chr12_82793173_ENST00000248306_ATP2B1_chr12_90005149_ENST00000359142_length(transcript)=5878nt_BP=1200nt
GCTAATTTGGGCCGAGCTGGCGCCTCACGGCCATGTTTGCGCCACCTACAGCCTCGGAGGGTGAGCGTCATGGCGGCTTCTTGCCCTCTC
CCGGTGACCCCGGACCTGCCCACGCTGCGTGCCAAGTTGCAGGGACTGCTGCAGTTCCTGAGGGATGCCCTGTCCATTTCCAATGCACAT
ACCGTGGATTTCTACACAGAATCCGTGTGGGAGGAGCTGGTCGACTTGCCACCGGAGACAGTGCTGGCTGCGCTGAGGAAGTCAGCGTCG
GAGACGGAGGCCCTGCCCTCAGAGACGCGCCCCCTAGTGGAAGCAGAGTGGGAAGCAGGTATGACTGATTTTCCCAAAATATTTTGTGAA
ACTTCTCAGAAGTTGGTGAGTGTGGAAGCCTTTGCTCTGGCTGCGAAATACTATTCTGTACAAAACTTGGGAATATGTACTCCTTTTGAA
CAGTTGCTTGTAGCCCTTCGAGGAAATCAAAACCAGAGAATTGGTGAAAATCAGAAGGCAGTTGAGTTTATGAATATGAAGAAATCTCAT
GAAGTTCAGGCAATGTCAGAGCTGATCAGCAGTATTGCTGACTACTATGGAATAAAGCAGGTGATTGACTTGGGTTCCGGTAAAGGCTAC
CTAAGCTCTTTTTTGTCCTTGAAGTATGGCTTAAAAGTTTATGGAATTGATTCTTCAAATACCAATACTCATGGAGCTGAGGAGAGAAAC
AGAAAATTGAAGAAACATTGGAAACTCTGTCATGCTCAGTCAAGATTAGATGTCAATGGACTAGCATTAAAAATGGCAAAAGAAAGGAAA
GTGCAAAATAAAGTTAAAAATAAAGCTGATACTGAGGAAGTGTTTAACAACAGTCCTACAAATCAAGAAAAGATGCCTACCTCAGCTATT
TTGCCTGATTTTTCTGGCTCTGTAATTTCTAATATCAGAAACCAAATGGAAACCCTTCATTCTCAGCCACATCAAGAAGAAAATTTGTGT
TTTGAAAATTCCTTTTCTCTTATAAACCTTTTGCCTATTAATGCTGTAGAGCCTACTTCTTCACAGCAAATACCCAACAGAGAAACATCT
GAAGCCAATAAAGAGAGAAGAAAAATGACATCAAAGTCAAGTGAATCAAATATATATTCACCTTTAACCTCTTTTATCACTGCTGATTCA
GAACTCCATGACATTATTAAAGATTTGGAGGTGCCAGATGCAATTAAAAAGTGTCAGAGGGCTGGAATTACTGTGCGGATGGTCACTGGT
GATAATATTAATACTGCTCGGGCCATTGCTACCAAATGTGGTATTTTACATCCTGGGGAAGATTTTCTGTGCCTAGAAGGTAAAGATTTT
AACAGAAGAATACGAAATGAAAAAGGAGAGATTGAGCAAGAGAGGATAGACAAGATTTGGCCAAAACTTCGAGTACTTGCAAGATCATCT
CCTACTGATAAGCATACACTGGTTAAAGGTATAATTGACAGCACTGTCTCAGACCAACGCCAGGTTGTAGCTGTAACTGGTGATGGTACA
AATGATGGCCCAGCACTAAAGAAAGCAGATGTTGGATTTGCAATGGGTATTGCTGGAACTGATGTAGCTAAAGAAGCATCCGATATTATT
CTCACAGATGACAACTTTACAAGCATTGTTAAAGCAGTTATGTGGGGACGAAATGTCTATGACAGCATCTCAAAATTCCTTCAGTTCCAA
CTTACTGTTAATGTAGTAGCAGTGATTGTTGCTTTTACGGGCGCCTGCATTACTCAAGACTCACCGCTTAAGGCTGTGCAGATGCTGTGG
GTAAACCTCATAATGGATACACTCGCTTCCCTGGCTCTGGCAACGGAACCACCCACTGAGTCTCTCTTGCTTCGGAAACCTTATGGTAGA
AATAAGCCTCTCATCTCACGTACAATGATGAAGAATATTTTGGGTCATGCATTCTATCAACTTGTAGTAGTCTTTACACTCTTATTTGCT
GGAGAAAAGTTTTTTGACATTGATAGTGGAAGAAATGCTCCTTTGCATGCTCCTCCTTCAGAACATTATACTATTGTTTTTAATACCTTT
GTGCTGATGCAACTTTTCAACGAAATAAATGCCCGGAAAATTCATGGTGAAAGAAATGTATTCGAAGGAATCTTTAACAATGCCATCTTC
TGCACAATTGTTTTAGGCACTTTTGTGGTACAGATAATAATTGTGCAGTTTGGTGGAAAACCTTTCAGTTGTTCAGAACTTTCAATAGAA
CAGTGGCTATGGTCAATATTCCTAGGAATGGGAACATTACTCTGGGGCCAGCTTATTTCAACAATTCCAACTAGCCGTTTAAAATTCCTC
AAAGAAGCTGGTCATGGAACACAAAAGGAAGAAATACCTGAGGAGGAATTAGCAGAGGATGTTGAAGAGATTGATCACGCTGAAAGGGAG
TTGCGGCGTGGCCAAATCTTGTGGTTTAGAGGTCTGAACAGAATCCAAACACAGATGGATGTAGTGAATGCTTTCCAGAGTGGAAGTTCC
ATTCAGGGGGCTCTAAGGCGGCAACCCTCCATCGCCAGCCAGCATCATGATGTAACAAATATTTCTACCCCTACACATGTAGTGTTTTCC
TCTTCTACTGCTTCTACTACTGTGGGGTATTCGAGTGGTGAATGCATTTCGTAGTTCTTTATATGAAGGGTTAGAAAAACCGGAATCAAG
AAGTTCGATTCACAACTTTATGACACATCCTGAGTTTAGGATAGAAGATTCAGAGCCTCATATCCCCCTTATTGATGACACTGATGCCGA
AGATGATGCTCCTACAAAACGTAACTCCAGTCCTCCACCCTCTCCCAACAAAAATAACAATGCTGTTGACAGTGGAATTCACCTTACAAT
AGAAATGAACAAGTCTGCTACCTCTTCATCCCCAGGAAGCCCACTACATAGTTTGGAAACATCACTCTGATTGTAAGCTGAATGTTAACA
CACTAGCTGCATTGTAAAGAAACAAATTGAAACTGGGTCTTTTCACATATTGTGATGGACAAGCTAGTATTCTTGTCTTTGGACTTCAAC
AGAAGACACACTTGTACGAATGTAGATTTATTTTTTTAAAAAAAAAAAAGCAAAGCTTTCTGCCAGACTGAGGGTGCTTTTTGGGGGGTG
GGAGAAATGAACTGACAGATAAACAGTAACTCAGCGTAAGTGACCTGTGGATCATCAGTAGTACCCAAGCATGGTCCTGAACAGTGTATT
AGCAGAGCTTTAGTTTATCTCAGTCCTGGATGGGAGAGAGAGGGAGGAGTAAAACTGGGCAAGACAAAGAGCCCTGGATCGTTGAATTGA
TAGTTTAATTTCTGCTGTTGGCTGTTAATAATTTGGATTATTTATGTTTATAAATGATACAGATCTGTTTACAAGGTTTGTAGATACTTT
TTTTGTTCCTGTTCATAGATGGGAAGCTTCCTTATAACTGATGCAGAGAAAAATTAGTCCTTCAAATACTGCTGTATTTTCAGGAAAAAA
AAAAAAAGGGGTGTTTCTATTGAAACTGTACTAAATTTTTGCCTACAATTTACCTTGTTAAATATTGTAGATAAATTGCTAATACTAATA
GCCAAATAGATAACACTAATGCTTTGTTTAAAAAAACGAAAAAAACAAAACAAAACAAAAAAACATGAGCAGTGGTGTTCTAATGAAGTT
ATGACATCTGTCCTAATTAGTTTCTTAAATACATTTACTACTTAATGGTTTTGAAGCAACTGTTTAATTTTTAAAATTTTTGAAAACTTG
CTAATAACCTTTTGTTCAGAATTTAGTAGATTGTTTAATGCAGGACATCAACTACATAATGAAAGATGCTTGAAATGCTTTTGTTATTTC
AGGCAAATCAAATTAAATCAGACTATCAAACTACAAGAGAACCTTAGTCTTTTTTGTTTTTGTCTAAACATGTTAGTTTAGTGATGTCTT
GGTGAACTGTGAGTGAACTGTATTGATTTTTCTAATCTTTAGAGACCTTCACACAGCATGAGGGCTGTTGGCATTTTGAAAAAGGTTAAT
AAGTAGAAGCATACATGTTTTCCTTTTGTTTTTGAAACTTGTTTGTAAACATAAATAAATATGCCCTTTTATTAAATAAATTCATGGCAA
TGTTTTTTTAAAAGACATTTCAGCTTCTTTACTCAGTTCTGCATATACAGTGCATCAGTCTGTTCTCTTTGACCACAATTGGAATACATT
TCAAGATGGTAACAGCCCCATGAAGTACCGCTTTAATTCCTTGCTGGTAATCTAATAGAATCAGATTAAGAAAATTAACACAATTTTACC
ATTTGACATACTCTTCATTGAATTTAGTTTGTCTAAAATAGTCTCACAGGTAAAAAACATAACAACAATGACCACCATTGTCTTTGATAC
ATTTATTTTAATTCTTAAGTGGCCAAATAACAGATTAGGTAAAATGAGATTACATGAAAAGGTTCTAAAATGATATATTTAGATGCAATA
ATTAACCATATGCTAGAATGCCCACCTCTAAGCCAATTGGATTCTTTAGCTCTCTTTTTCTTTCCTTCATCTACCTTCTTCTCTTTTTTG
CCTCTGTCTTTACCCTTTAGAAACTGGCATGTGTTAGGGCCCAGATTTCACCAGATACACAATCCTCAGGCTGACATAAAGTTTACGAGG
ACTGCTACTATAACTGAGAGTGCTGACCAAGCAAAGAAACATTTAGTTGATGGTGCTTGATATTTTTGGTGGGTGGGGGAAATCTTTTTC
TCACCATCAAATCTTTGCAGTAATCCTCTGCAGGTCTTAGAAACACATTGGCTCTGTCAGCATTTGTAATTGTACATTTATTCATCAGGT
ATTTATAGTGAATCATACTGTAAAAAAGAGGTAGCATGATATGCTGGAAAGCATATTAGACTAGGAGTCAAGACCTGGTTTCTAGTCTTG
GTTTTGCCATTAATGTGCTGCATGATCTTGGGAAAATCATTTACCCTAAATAAGGGTGGTGGACTATCTTGAAGAACCCTTTCAACTCTA
AAAATTGACCCTATCAACTGGAGAGCCCACAAGGCATAGGGAATAGAGAAAAGGGAAATGTTTTCAGTTTTCTTTTTTATTTTGGTTATG
CTTAAATATGAATGTAATTACCAAAAGATTTAGAAGTGCATGTGCTTTGGAGGATTTGTATTGAGCTTTTACAGTATTCATTTTTCAACT
CAAGGCAATGGCTTTCTACACCAACTCTAATCCATAAACGGGTCTTATGACATCTATGAAGTAGTAGCAAGACATGCTTAGTGTGTATTT
CTCTCTTTGAGACACTGTAATTTCTACCAGAAATTTCCAGAGCATTATGTAGGTAGAAAAAAATGCAAGCAAGCTGTTAAAGATCTTGGA
TCCCATTATATAGTATGTATAGCTGAAATCTGTAATTCAATCACTTTTTCTCTTTTATCCTCTAACCAAAAAATTGTTTAATTTTGCATC
CCAAATGTTTTTAATCTTTGTATATTTTTTAAAAATCCTTTTCTCCTCATCATTGCCTTTTTTGTGGTTGTAAATAGACTTACTTGCACT
TTGAAGATGAGTTACTCCTTGTCATCTTACAAATATGTGATATGGTAATTTTCATAACAGATGTCAGTTTTGAACCAAGAATTGGTGATT
TGTTTATAAGAAAAAAACTGGCTTCATTTCTGTGAAATTGCTCTTTGAAAATTTCTTTTTACACGTGTAAGCCAACTGAGATACCGTGAT
GGTGTTGATTTCTTTCAATGATGCTTACCATCTATTTTAGCCACTGAGCCTTTTATTATTTGTCTATTTGTAAAGTTTATTTGTCTTAAC
TCATTTAATAAATATACTGTTTATCTGT

>53111_53111_3_METTL25-ATP2B1_METTL25_chr12_82793173_ENST00000248306_ATP2B1_chr12_90005149_ENST00000359142_length(amino acids)=885AA_BP=398
MGRAGASRPCLRHLQPRRVSVMAASCPLPVTPDLPTLRAKLQGLLQFLRDALSISNAHTVDFYTESVWEELVDLPPETVLAALRKSASET
EALPSETRPLVEAEWEAGMTDFPKIFCETSQKLVSVEAFALAAKYYSVQNLGICTPFEQLLVALRGNQNQRIGENQKAVEFMNMKKSHEV
QAMSELISSIADYYGIKQVIDLGSGKGYLSSFLSLKYGLKVYGIDSSNTNTHGAEERNRKLKKHWKLCHAQSRLDVNGLALKMAKERKVQ
NKVKNKADTEEVFNNSPTNQEKMPTSAILPDFSGSVISNIRNQMETLHSQPHQEENLCFENSFSLINLLPINAVEPTSSQQIPNRETSEA
NKERRKMTSKSSESNIYSPLTSFITADSELHDIIKDLEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNR
RIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILT
DDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNK
PLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCT
IVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELR
RGQILWFRGLNRIQTQMDVVNAFQSGSSIQGALRRQPSIASQHHDVTNISTPTHVVFSSSTASTTVGYSSGECIS

--------------------------------------------------------------
>53111_53111_4_METTL25-ATP2B1_METTL25_chr12_82793173_ENST00000248306_ATP2B1_chr12_90005149_ENST00000393164_length(transcript)=2938nt_BP=1200nt
GCTAATTTGGGCCGAGCTGGCGCCTCACGGCCATGTTTGCGCCACCTACAGCCTCGGAGGGTGAGCGTCATGGCGGCTTCTTGCCCTCTC
CCGGTGACCCCGGACCTGCCCACGCTGCGTGCCAAGTTGCAGGGACTGCTGCAGTTCCTGAGGGATGCCCTGTCCATTTCCAATGCACAT
ACCGTGGATTTCTACACAGAATCCGTGTGGGAGGAGCTGGTCGACTTGCCACCGGAGACAGTGCTGGCTGCGCTGAGGAAGTCAGCGTCG
GAGACGGAGGCCCTGCCCTCAGAGACGCGCCCCCTAGTGGAAGCAGAGTGGGAAGCAGGTATGACTGATTTTCCCAAAATATTTTGTGAA
ACTTCTCAGAAGTTGGTGAGTGTGGAAGCCTTTGCTCTGGCTGCGAAATACTATTCTGTACAAAACTTGGGAATATGTACTCCTTTTGAA
CAGTTGCTTGTAGCCCTTCGAGGAAATCAAAACCAGAGAATTGGTGAAAATCAGAAGGCAGTTGAGTTTATGAATATGAAGAAATCTCAT
GAAGTTCAGGCAATGTCAGAGCTGATCAGCAGTATTGCTGACTACTATGGAATAAAGCAGGTGATTGACTTGGGTTCCGGTAAAGGCTAC
CTAAGCTCTTTTTTGTCCTTGAAGTATGGCTTAAAAGTTTATGGAATTGATTCTTCAAATACCAATACTCATGGAGCTGAGGAGAGAAAC
AGAAAATTGAAGAAACATTGGAAACTCTGTCATGCTCAGTCAAGATTAGATGTCAATGGACTAGCATTAAAAATGGCAAAAGAAAGGAAA
GTGCAAAATAAAGTTAAAAATAAAGCTGATACTGAGGAAGTGTTTAACAACAGTCCTACAAATCAAGAAAAGATGCCTACCTCAGCTATT
TTGCCTGATTTTTCTGGCTCTGTAATTTCTAATATCAGAAACCAAATGGAAACCCTTCATTCTCAGCCACATCAAGAAGAAAATTTGTGT
TTTGAAAATTCCTTTTCTCTTATAAACCTTTTGCCTATTAATGCTGTAGAGCCTACTTCTTCACAGCAAATACCCAACAGAGAAACATCT
GAAGCCAATAAAGAGAGAAGAAAAATGACATCAAAGTCAAGTGAATCAAATATATATTCACCTTTAACCTCTTTTATCACTGCTGATTCA
GAACTCCATGACATTATTAAAGATTTGGAGGTGCCAGATGCAATTAAAAAGTGTCAGAGGGCTGGAATTACTGTGCGGATGGTCACTGGT
GATAATATTAATACTGCTCGGGCCATTGCTACCAAATGTGGTATTTTACATCCTGGGGAAGATTTTCTGTGCCTAGAAGGTAAAGATTTT
AACAGAAGAATACGAAATGAAAAAGGAGAGATTGAGCAAGAGAGGATAGACAAGATTTGGCCAAAACTTCGAGTACTTGCAAGATCATCT
CCTACTGATAAGCATACACTGGTTAAAGGTATAATTGACAGCACTGTCTCAGACCAACGCCAGGTTGTAGCTGTAACTGGTGATGGTACA
AATGATGGCCCAGCACTAAAGAAAGCAGATGTTGGATTTGCAATGGGTATTGCTGGAACTGATGTAGCTAAAGAAGCATCCGATATTATT
CTCACAGATGACAACTTTACAAGCATTGTTAAAGCAGTTATGTGGGGACGAAATGTCTATGACAGCATCTCAAAATTCCTTCAGTTCCAA
CTTACTGTTAATGTAGTAGCAGTGATTGTTGCTTTTACGGGCGCCTGCATTACTCAAGACTCACCGCTTAAGGCTGTGCAGATGCTGTGG
GTAAACCTCATAATGGATACACTCGCTTCCCTGGCTCTGGCAACGGAACCACCCACTGAGTCTCTCTTGCTTCGGAAACCTTATGGTAGA
AATAAGCCTCTCATCTCACGTACAATGATGAAGAATATTTTGGGTCATGCATTCTATCAACTTGTAGTAGTCTTTACACTCTTATTTGCT
GGAGAAAAGTTTTTTGACATTGATAGTGGAAGAAATGCTCCTTTGCATGCTCCTCCTTCAGAACATTATACTATTGTTTTTAATACCTTT
GTGCTGATGCAACTTTTCAACGAAATAAATGCCCGGAAAATTCATGGTGAAAGAAATGTATTCGAAGGAATCTTTAACAATGCCATCTTC
TGCACAATTGTTTTAGGCACTTTTGTGGTACAGATAATAATTGTGCAGTTTGGTGGAAAACCTTTCAGTTGTTCAGAACTTTCAATAGAA
CAGTGGCTATGGTCAATATTCCTAGGAATGGGAACATTACTCTGGGGCCAGCTTATTTCAACAATTCCAACTAGCCGTTTAAAATTCCTC
AAAGAAGCTGGTCATGGAACACAAAAGGAAGAAATACCTGAGGAGGAATTAGCAGAGGATGTTGAAGAGATTGATCACGCTGAAAGGGAG
TTGCGGCGTGGCCAAATCTTGTGGTTTAGAGGTCTGAACAGAATCCAAACACAGATTCGAGTGGTGAATGCATTTCGTAGTTCTTTATAT
GAAGGGTTAGAAAAACCGGAATCAAGAAGTTCGATTCACAACTTTATGACACATCCTGAGTTTAGGATAGAAGATTCAGAGCCTCATATC
CCCCTTATTGATGACACTGATGCCGAAGATGATGCTCCTACAAAACGTAACTCCAGTCCTCCACCCTCTCCCAACAAAAATAACAATGCT
GTTGACAGTGGAATTCACCTTACAATAGAAATGAACAAGTCTGCTACCTCTTCATCCCCAGGAAGCCCACTACATAGTTTGGAAACATCA
CTCTGATTGTAAGCTGAATGTTAACACACTAGCTGCATTGTAAAGAAACAAATTGAAACTGGGTCTTTTCACATATTGTGATGGACAAGC
TAGTATTCTTGTCTTTGGACTTCAACAGAAGACACACTTGTACGAATGTAGATTTATT

>53111_53111_4_METTL25-ATP2B1_METTL25_chr12_82793173_ENST00000248306_ATP2B1_chr12_90005149_ENST00000393164_length(amino acids)=929AA_BP=398
MGRAGASRPCLRHLQPRRVSVMAASCPLPVTPDLPTLRAKLQGLLQFLRDALSISNAHTVDFYTESVWEELVDLPPETVLAALRKSASET
EALPSETRPLVEAEWEAGMTDFPKIFCETSQKLVSVEAFALAAKYYSVQNLGICTPFEQLLVALRGNQNQRIGENQKAVEFMNMKKSHEV
QAMSELISSIADYYGIKQVIDLGSGKGYLSSFLSLKYGLKVYGIDSSNTNTHGAEERNRKLKKHWKLCHAQSRLDVNGLALKMAKERKVQ
NKVKNKADTEEVFNNSPTNQEKMPTSAILPDFSGSVISNIRNQMETLHSQPHQEENLCFENSFSLINLLPINAVEPTSSQQIPNRETSEA
NKERRKMTSKSSESNIYSPLTSFITADSELHDIIKDLEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNR
RIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILT
DDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNK
PLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCT
IVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELR
RGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVD
SGIHLTIEMNKSATSSSPGSPLHSLETSL

--------------------------------------------------------------
>53111_53111_5_METTL25-ATP2B1_METTL25_chr12_82793173_ENST00000248306_ATP2B1_chr12_90005149_ENST00000428670_length(transcript)=5708nt_BP=1200nt
GCTAATTTGGGCCGAGCTGGCGCCTCACGGCCATGTTTGCGCCACCTACAGCCTCGGAGGGTGAGCGTCATGGCGGCTTCTTGCCCTCTC
CCGGTGACCCCGGACCTGCCCACGCTGCGTGCCAAGTTGCAGGGACTGCTGCAGTTCCTGAGGGATGCCCTGTCCATTTCCAATGCACAT
ACCGTGGATTTCTACACAGAATCCGTGTGGGAGGAGCTGGTCGACTTGCCACCGGAGACAGTGCTGGCTGCGCTGAGGAAGTCAGCGTCG
GAGACGGAGGCCCTGCCCTCAGAGACGCGCCCCCTAGTGGAAGCAGAGTGGGAAGCAGGTATGACTGATTTTCCCAAAATATTTTGTGAA
ACTTCTCAGAAGTTGGTGAGTGTGGAAGCCTTTGCTCTGGCTGCGAAATACTATTCTGTACAAAACTTGGGAATATGTACTCCTTTTGAA
CAGTTGCTTGTAGCCCTTCGAGGAAATCAAAACCAGAGAATTGGTGAAAATCAGAAGGCAGTTGAGTTTATGAATATGAAGAAATCTCAT
GAAGTTCAGGCAATGTCAGAGCTGATCAGCAGTATTGCTGACTACTATGGAATAAAGCAGGTGATTGACTTGGGTTCCGGTAAAGGCTAC
CTAAGCTCTTTTTTGTCCTTGAAGTATGGCTTAAAAGTTTATGGAATTGATTCTTCAAATACCAATACTCATGGAGCTGAGGAGAGAAAC
AGAAAATTGAAGAAACATTGGAAACTCTGTCATGCTCAGTCAAGATTAGATGTCAATGGACTAGCATTAAAAATGGCAAAAGAAAGGAAA
GTGCAAAATAAAGTTAAAAATAAAGCTGATACTGAGGAAGTGTTTAACAACAGTCCTACAAATCAAGAAAAGATGCCTACCTCAGCTATT
TTGCCTGATTTTTCTGGCTCTGTAATTTCTAATATCAGAAACCAAATGGAAACCCTTCATTCTCAGCCACATCAAGAAGAAAATTTGTGT
TTTGAAAATTCCTTTTCTCTTATAAACCTTTTGCCTATTAATGCTGTAGAGCCTACTTCTTCACAGCAAATACCCAACAGAGAAACATCT
GAAGCCAATAAAGAGAGAAGAAAAATGACATCAAAGTCAAGTGAATCAAATATATATTCACCTTTAACCTCTTTTATCACTGCTGATTCA
GAACTCCATGACATTATTAAAGATTTGGAGGTGCCAGATGCAATTAAAAAGTGTCAGAGGGCTGGAATTACTGTGCGGATGGTCACTGGT
GATAATATTAATACTGCTCGGGCCATTGCTACCAAATGTGGTATTTTACATCCTGGGGAAGATTTTCTGTGCCTAGAAGGTAAAGATTTT
AACAGAAGAATACGAAATGAAAAAGGAGAGATTGAGCAAGAGAGGATAGACAAGATTTGGCCAAAACTTCGAGTACTTGCAAGATCATCT
CCTACTGATAAGCATACACTGGTTAAAGGTATAATTGACAGCACTGTCTCAGACCAACGCCAGGTTGTAGCTGTAACTGGTGATGGTACA
AATGATGGCCCAGCACTAAAGAAAGCAGATGTTGGATTTGCAATGGGTATTGCTGGAACTGATGTAGCTAAAGAAGCATCCGATATTATT
CTCACAGATGACAACTTTACAAGCATTGTTAAAGCAGTTATGTGGGGACGAAATGTCTATGACAGCATCTCAAAATTCCTTCAGTTCCAA
CTTACTGTTAATGTAGTAGCAGTGATTGTTGCTTTTACGGGCGCCTGCATTACTCAAGACTCACCGCTTAAGGCTGTGCAGATGCTGTGG
GTAAACCTCATAATGGATACACTCGCTTCCCTGGCTCTGGCAACGGAACCACCCACTGAGTCTCTCTTGCTTCGGAAACCTTATGGTAGA
AATAAGCCTCTCATCTCACGTACAATGATGAAGAATATTTTGGGTCATGCATTCTATCAACTTGTAGTAGTCTTTACACTCTTATTTGCT
GGAGAAAAGTTTTTTGACATTGATAGTGGAAGAAATGCTCCTTTGCATGCTCCTCCTTCAGAACATTATACTATTGTTTTTAATACCTTT
GTGCTGATGCAACTTTTCAACGAAATAAATGCCCGGAAAATTCATGGTGAAAGAAATGTATTCGAAGGAATCTTTAACAATGCCATCTTC
TGCACAATTGTTTTAGGCACTTTTGTGGTACAGATAATAATTGTGCAGTTTGGTGGAAAACCTTTCAGTTGTTCAGAACTTTCAATAGAA
CAGTGGCTATGGTCAATATTCCTAGGAATGGGAACATTACTCTGGGGCCAGCTTATTTCAACAATTCCAACTAGCCGTTTAAAATTCCTC
AAAGAAGCTGGTCATGGAACACAAAAGGAAGAAATACCTGAGGAGGAATTAGCAGAGGATGTTGAAGAGATTGATCACGCTGAAAGGGAG
TTGCGGCGTGGCCAAATCTTGTGGTTTAGAGGTCTGAACAGAATCCAAACACAGATTCGAGTGGTGAATGCATTTCGTAGTTCTTTATAT
GAAGGGTTAGAAAAACCGGAATCAAGAAGTTCGATTCACAACTTTATGACACATCCTGAGTTTAGGATAGAAGATTCAGAGCCTCATATC
CCCCTTATTGATGACACTGATGCCGAAGATGATGCTCCTACAAAACGTAACTCCAGTCCTCCACCCTCTCCCAACAAAAATAACAATGCT
GTTGACAGTGGAATTCACCTTACAATAGAAATGAACAAGTCTGCTACCTCTTCATCCCCAGGAAGCCCACTACATAGTTTGGAAACATCA
CTCTGATTGTAAGCTGAATGTTAACACACTAGCTGCATTGTAAAGAAACAAATTGAAACTGGGTCTTTTCACATATTGTGATGGACAAGC
TAGTATTCTTGTCTTTGGACTTCAACAGAAGACACACTTGTACGAATGTAGATTTATTTTTTTAAAAAAAAAAAAGCAAAGCTTTCTGCC
AGACTGAGGGTGCTTTTTGGGGGGTGGGAGAAATGAACTGACAGATAAACAGTAACTCAGCGTAAGTGACCTGTGGATCATCAGTAGTAC
CCAAGCATGGTCCTGAACAGTGTATTAGCAGAGCTTTAGTTTATCTCAGTCCTGGATGGGAGAGAGAGGGAGGAGTAAAACTGGGCAAGA
CAAAGAGCCCTGGATCGTTGAATTGATAGTTTAATTTCTGCTGTTGGCTGTTAATAATTTGGATTATTTATGTTTATAAATGATACAGAT
CTGTTTACAAGGTTTGTAGATACTTTTTTTGTTCCTGTTCATAGATGGGAAGCTTCCTTATAACTGATGCAGAGAAAAATTAGTCCTTCA
AATACTGCTGTATTTTCAGGAAAAAAAAAAAAAGGGGTGTTTCTATTGAAACTGTACTAAATTTTTGCCTACAATTTACCTTGTTAAATA
TTGTAGATAAATTGCTAATACTAATAGCCAAATAGATAACACTAATGCTTTGTTTAAAAAAACGAAAAAAACAAAACAAAACAAAAAAAC
ATGAGCAGTGGTGTTCTAATGAAGTTATGACATCTGTCCTAATTAGTTTCTTAAATACATTTACTACTTAATGGTTTTGAAGCAACTGTT
TAATTTTTAAAATTTTTGAAAACTTGCTAATAACCTTTTGTTCAGAATTTAGTAGATTGTTTAATGCAGGACATCAACTACATAATGAAA
GATGCTTGAAATGCTTTTGTTATTTCAGGCAAATCAAATTAAATCAGACTATCAAACTACAAGAGAACCTTAGTCTTTTTTGTTTTTGTC
TAAACATGTTAGTTTAGTGATGTCTTGGTGAACTGTGAGTGAACTGTATTGATTTTTCTAATCTTTAGAGACCTTCACACAGCATGAGGG
CTGTTGGCATTTTGAAAAAGGTTAATAAGTAGAAGCATACATGTTTTCCTTTTGTTTTTGAAACTTGTTTGTAAACATAAATAAATATGC
CCTTTTATTAAATAAATTCATGGCAATGTTTTTTTAAAAGACATTTCAGCTTCTTTACTCAGTTCTGCATATACAGTGCATCAGTCTGTT
CTCTTTGACCACAATTGGAATACATTTCAAGATGGTAACAGCCCCATGAAGTACCGCTTTAATTCCTTGCTGGTAATCTAATAGAATCAG
ATTAAGAAAATTAACACAATTTTACCATTTGACATACTCTTCATTGAATTTAGTTTGTCTAAAATAGTCTCACAGGTAAAAAACATAACA
ACAATGACCACCATTGTCTTTGATACATTTATTTTAATTCTTAAGTGGCCAAATAACAGATTAGGTAAAATGAGATTACATGAAAAGGTT
CTAAAATGATATATTTAGATGCAATAATTAACCATATGCTAGAATGCCCACCTCTAAGCCAATTGGATTCTTTAGCTCTCTTTTTCTTTC
CTTCATCTACCTTCTTCTCTTTTTTGCCTCTGTCTTTACCCTTTAGAAACTGGCATGTGTTAGGGCCCAGATTTCACCAGATACACAATC
CTCAGGCTGACATAAAGTTTACGAGGACTGCTACTATAACTGAGAGTGCTGACCAAGCAAAGAAACATTTAGTTGATGGTGCTTGATATT
TTTGGTGGGTGGGGGAAATCTTTTTCTCACCATCAAATCTTTGCAGTAATCCTCTGCAGGTCTTAGAAACACATTGGCTCTGTCAGCATT
TGTAATTGTACATTTATTCATCAGGTATTTATAGTGAATCATACTGTAAAAAAGAGGTAGCATGATATGCTGGAAAGCATATTAGACTAG
GAGTCAAGACCTGGTTTCTAGTCTTGGTTTTGCCATTAATGTGCTGCATGATCTTGGGAAAATCATTTACCCTAAATAAGGGTGGTGGAC
TATCTTGAAGAACCCTTTCAACTCTAAAAATTGACCCTATCAACTGGAGAGCCCACAAGGCATAGGGAATAGAGAAAAGGGAAATGTTTT
CAGTTTTCTTTTTTATTTTGGTTATGCTTAAATATGAATGTAATTACCAAAAGATTTAGAAGTGCATGTGCTTTGGAGGATTTGTATTGA
GCTTTTACAGTATTCATTTTTCAACTCAAGGCAATGGCTTTCTACACCAACTCTAATCCATAAACGGGTCTTATGACATCTATGAAGTAG
TAGCAAGACATGCTTAGTGTGTATTTCTCTCTTTGAGACACTGTAATTTCTACCAGAAATTTCCAGAGCATTATGTAGGTAGAAAAAAAT
GCAAGCAAGCTGTTAAAGATCTTGGATCCCATTATATAGTATGTATAGCTGAAATCTGTAATTCAATCACTTTTTCTCTTTTATCCTCTA
ACCAAAAAATTGTTTAATTTTGCATCCCAAATGTTTTTAATCTTTGTATATTTTTTAAAAATCCTTTTCTCCTCATCATTGCCTTTTTTG
TGGTTGTAAATAGACTTACTTGCACTTTGAAGATGAGTTACTCCTTGTCATCTTACAAATATGTGATATGGTAATTTTCATAACAGATGT
CAGTTTTGAACCAAGAATTGGTGATTTGTTTATAAGAAAAAAACTGGCTTCATTTCTGTGAAATTGCTCTTTGAAAATTTCTTTTTACAC
GTGTAAGCCAACTGAGATACCGTGATGGTGTTGATTTCTTTCAATGATGCTTACCATCTATTTTAGCCACTGAGCCTTTTATTATTTGTC
TATTTGTAAAGTTTATTTGTCTTAACTCATTTAATAAA

>53111_53111_5_METTL25-ATP2B1_METTL25_chr12_82793173_ENST00000248306_ATP2B1_chr12_90005149_ENST00000428670_length(amino acids)=929AA_BP=398
MGRAGASRPCLRHLQPRRVSVMAASCPLPVTPDLPTLRAKLQGLLQFLRDALSISNAHTVDFYTESVWEELVDLPPETVLAALRKSASET
EALPSETRPLVEAEWEAGMTDFPKIFCETSQKLVSVEAFALAAKYYSVQNLGICTPFEQLLVALRGNQNQRIGENQKAVEFMNMKKSHEV
QAMSELISSIADYYGIKQVIDLGSGKGYLSSFLSLKYGLKVYGIDSSNTNTHGAEERNRKLKKHWKLCHAQSRLDVNGLALKMAKERKVQ
NKVKNKADTEEVFNNSPTNQEKMPTSAILPDFSGSVISNIRNQMETLHSQPHQEENLCFENSFSLINLLPINAVEPTSSQQIPNRETSEA
NKERRKMTSKSSESNIYSPLTSFITADSELHDIIKDLEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNR
RIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILT
DDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNK
PLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCT
IVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELR
RGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVD
SGIHLTIEMNKSATSSSPGSPLHSLETSL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for METTL25-ATP2B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for METTL25-ATP2B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for METTL25-ATP2B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0010054Coronary Arteriosclerosis1CTD_human
TgeneC0020538Hypertensive disease1CTD_human
TgeneC0086543Cataract1CTD_human
TgeneC0524524Pseudoaphakia1CTD_human
TgeneC1510497Lens Opacities1CTD_human
TgeneC1956346Coronary Artery Disease1CTD_human