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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C7orf50-MMD2 (FusionGDB2 ID:HG84310TG221938)

Fusion Gene Summary for C7orf50-MMD2

check button Fusion gene summary
Fusion gene informationFusion gene name: C7orf50-MMD2
Fusion gene ID: hg84310tg221938
HgeneTgene
Gene symbol

C7orf50

MMD2

Gene ID

84310

221938

Gene namechromosome 7 open reading frame 50monocyte to macrophage differentiation associated 2
SynonymsYCR016WPAQR10
Cytomap('C7orf50')('MMD2')

7p22.3

7p22.1

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C7orf50monocyte to macrophage differentiation factor 2monocyte-to-macrophage differentiation-associated protein 2progestin and adipoQ receptor family member 10progestin and adipoQ receptor family member X
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000488073, ENST00000357429, 
ENST00000397098, ENST00000397100, 
Fusion gene scores* DoF score9 X 5 X 9=4053 X 3 X 2=18
# samples 134
** MAII scorelog2(13/405*10)=-1.63941028474353
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: C7orf50 [Title/Abstract] AND MMD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC7orf50(1166893)-MMD2(4965163), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMMD2

GO:0032880

regulation of protein localization

21968647

TgeneMMD2

GO:0045666

positive regulation of neuron differentiation

21968647

TgeneMMD2

GO:0045860

positive regulation of protein kinase activity

21968647

TgeneMMD2

GO:0046579

positive regulation of Ras protein signal transduction

21968647


check buttonFusion gene breakpoints across C7orf50 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MMD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A8ID-01AC7orf50chr7

1166893

-MMD2chr7

4965163

-


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Fusion Gene ORF analysis for C7orf50-MMD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000488073ENST00000401401C7orf50chr7

1166893

-MMD2chr7

4965163

-
5UTR-3CDSENST00000488073ENST00000404774C7orf50chr7

1166893

-MMD2chr7

4965163

-
5UTR-3CDSENST00000488073ENST00000406755C7orf50chr7

1166893

-MMD2chr7

4965163

-
Frame-shiftENST00000357429ENST00000401401C7orf50chr7

1166893

-MMD2chr7

4965163

-
Frame-shiftENST00000357429ENST00000404774C7orf50chr7

1166893

-MMD2chr7

4965163

-
Frame-shiftENST00000357429ENST00000406755C7orf50chr7

1166893

-MMD2chr7

4965163

-
Frame-shiftENST00000397098ENST00000406755C7orf50chr7

1166893

-MMD2chr7

4965163

-
Frame-shiftENST00000397100ENST00000406755C7orf50chr7

1166893

-MMD2chr7

4965163

-
In-frameENST00000397098ENST00000401401C7orf50chr7

1166893

-MMD2chr7

4965163

-
In-frameENST00000397098ENST00000404774C7orf50chr7

1166893

-MMD2chr7

4965163

-
In-frameENST00000397100ENST00000401401C7orf50chr7

1166893

-MMD2chr7

4965163

-
In-frameENST00000397100ENST00000404774C7orf50chr7

1166893

-MMD2chr7

4965163

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000397100C7orf50chr71166893-ENST00000404774MMD2chr74965163-2343170132935267
ENST00000397100C7orf50chr71166893-ENST00000401401MMD2chr74965163-2262170132863243
ENST00000397098C7orf50chr71166893-ENST00000404774MMD2chr74965163-3229105610181821267
ENST00000397098C7orf50chr71166893-ENST00000401401MMD2chr74965163-3148105610181749243

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397100ENST00000404774C7orf50chr71166893-MMD2chr74965163-0.0414721560.9585278
ENST00000397100ENST00000401401C7orf50chr71166893-MMD2chr74965163-0.027096870.97290313
ENST00000397098ENST00000404774C7orf50chr71166893-MMD2chr74965163-0.057978520.9420215
ENST00000397098ENST00000401401C7orf50chr71166893-MMD2chr74965163-0.0242295150.9757705

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Fusion Genomic Features for C7orf50-MMD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C7orf50-MMD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:1166893/chr7:4965163)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMMD2chr7:1166893chr7:4965163ENST0000040140107124_13215247.0Topological domainLumenal
TgeneMMD2chr7:1166893chr7:4965163ENST0000040140107154_18215247.0Topological domainCytoplasmic
TgeneMMD2chr7:1166893chr7:4965163ENST0000040140107204_20515247.0Topological domainLumenal
TgeneMMD2chr7:1166893chr7:4965163ENST0000040140107227_23315247.0Topological domainCytoplasmic
TgeneMMD2chr7:1166893chr7:4965163ENST0000040140107255_27015247.0Topological domainLumenal
TgeneMMD2chr7:1166893chr7:4965163ENST000004014010760_6515247.0Topological domainLumenal
TgeneMMD2chr7:1166893chr7:4965163ENST000004014010787_10215247.0Topological domainCytoplasmic
TgeneMMD2chr7:1166893chr7:4965163ENST0000040477407124_13215271.0Topological domainLumenal
TgeneMMD2chr7:1166893chr7:4965163ENST0000040477407154_18215271.0Topological domainCytoplasmic
TgeneMMD2chr7:1166893chr7:4965163ENST0000040477407204_20515271.0Topological domainLumenal
TgeneMMD2chr7:1166893chr7:4965163ENST0000040477407227_23315271.0Topological domainCytoplasmic
TgeneMMD2chr7:1166893chr7:4965163ENST0000040477407255_27015271.0Topological domainLumenal
TgeneMMD2chr7:1166893chr7:4965163ENST000004047740760_6515271.0Topological domainLumenal
TgeneMMD2chr7:1166893chr7:4965163ENST000004047740787_10215271.0Topological domainCytoplasmic
TgeneMMD2chr7:1166893chr7:4965163ENST0000040675508124_13215646.6666666666666Topological domainLumenal
TgeneMMD2chr7:1166893chr7:4965163ENST0000040675508154_18215646.6666666666666Topological domainCytoplasmic
TgeneMMD2chr7:1166893chr7:4965163ENST0000040675508204_20515646.6666666666666Topological domainLumenal
TgeneMMD2chr7:1166893chr7:4965163ENST0000040675508227_23315646.6666666666666Topological domainCytoplasmic
TgeneMMD2chr7:1166893chr7:4965163ENST0000040675508255_27015646.6666666666666Topological domainLumenal
TgeneMMD2chr7:1166893chr7:4965163ENST000004067550860_6515646.6666666666666Topological domainLumenal
TgeneMMD2chr7:1166893chr7:4965163ENST000004067550887_10215646.6666666666666Topological domainCytoplasmic
TgeneMMD2chr7:1166893chr7:4965163ENST0000040140107103_12315247.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040140107133_15315247.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040140107183_20315247.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040140107206_22615247.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040140107234_25415247.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST000004014010739_5915247.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST000004014010766_8615247.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040477407103_12315271.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040477407133_15315271.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040477407183_20315271.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040477407206_22615271.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040477407234_25415271.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST000004047740739_5915271.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST000004047740766_8615271.0TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040675508103_12315646.6666666666666TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040675508133_15315646.6666666666666TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040675508183_20315646.6666666666666TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040675508206_22615646.6666666666666TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST0000040675508234_25415646.6666666666666TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST000004067550839_5915646.6666666666666TransmembraneHelical
TgeneMMD2chr7:1166893chr7:4965163ENST000004067550866_8615646.6666666666666TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMMD2chr7:1166893chr7:4965163ENST00000401401071_3815247.0Topological domainCytoplasmic
TgeneMMD2chr7:1166893chr7:4965163ENST00000404774071_3815271.0Topological domainCytoplasmic
TgeneMMD2chr7:1166893chr7:4965163ENST00000406755081_3815646.6666666666666Topological domainCytoplasmic


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Fusion Gene Sequence for C7orf50-MMD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12040_12040_1_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397098_MMD2_chr7_4965163_ENST00000401401_length(transcript)=3148nt_BP=1056nt
GCGACGCAGCTGTTCACGCTTAGGTGGGCGACGTGGGCGCAGGTGGGCGCAGGTAGGCGCGTGGGGCGGCGGCGGGGTGGCCGGCGGGTC
AGGGCGCCAGGAGACCCAGAGCCCCGGGGCGGGCTCCCGCGGGGCTCCGCCCCCTCCACGTGGGTGCGCGGAGGCCCGGCGCGGCGCGAC
CGGGCGGCGGCCCTGGGGTCCGCGGTGCTGGGGAGGCTGGTGCGGCCGGTGCGGCCGGTGCGTCCCGGCGCGGGCTCCGACACCCGCACC
CGCCTCTGGGTTAACTCAGCGCGGGCGAGTGGAAGGGACTCAGCTGGCTCCTAGGTTTCAGGCCGTCAGGGCTTGCAGTGGCTCTGGTTT
CATTGTCTTTCTCTGAAGACGCCCTGATTGCCCTCCGAGGCTTTCAGCTCCCACTTTCTCTTTTTCAATTTTTGAGGCAGTGTCTCGCTG
TGCCACCCAGGCTGGAGTGCAATGGCGTGATCATAGCTCACTGCAGCCTCCACCTCCTGGGCTCAAGCCGTCCTCCCGCCTCATCCTCCC
AAGTAGCTGGGACCACATGCGCGCGCCACCACACCCGGATAATTTTTAAAAATGTTTTTTGTAGAAATGGGGTCTCACCATGTTACCCAG
GCTGGTCTCGAATTCTTGGGCTCAAGCGATGGATCCTCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCAACGCGCTTG
GCCTCACTTTCCATCATAAGCATGCTTTCCGTTTCCTTCCTTCCGTCATTCATTCATTCATTTTTAAAAAACGTTCATTGGGTTCCTCCT
GCACTGTTCGGGGCATTGGGCTACAGCTGTCAACAAGTGGAGACAAGTCTGTGATCTAGTGAACTTCCATTCTGGAGGGGAGAGACAGAT
GAACAAGGTGCACAGAGCAGGTGATGGATGGCAAAACAGAAGAGAAAAGTTCCTGAAGTGACAGAGAAAAAGAACAAAAAGCTGAAGAAG
GCGTCAGCAGAGGGGCCACTGCTGGGCCCTGAGGCTGCACCAAGTGGCGAAGGAGCCGGCTCCAAGGTTCATGAACCACCGAGTCCCTGC
CCACAAGAGGTACCAGCCCACAGAGTATGAACATGCGGCCAACTGTGCCACCCATGCTTTCTGGATCATCCCCAGCATCCTGGGCAGCTC
CAACCTCTACTTCCTGTCGGACGATGACTGGGAGACCATCTCTGCCTGGATCTACGGCCTCGGCCTCTGCGGCCTCTTCGTGGTGTCCAC
TGTGTTTCACACCATCTCCTGGAAGAAGAGCCACCTCAGGATGGTGGAACACTGTCTACACATGTTCGACCGGATGGTCATCTATTTCTT
CATAGCGGCTTCCTACGCACCCTGGCTGAACCTTCGGGAGCTGGGCCCCTGGGCCTCCCACATGCGCTGGCTGGTCTGGATTATGGCTTC
CGTGGGCACCATCTATGTCTTCTTCTTCCATGAGCGGTACAAGCTTGTGGAGCTTCTCTGCTACGTCGTAATGGGCTTCTTCCCCGCCCT
GGTCATCCTCTCCATGCCCAACACCGAGGGCATCTGGGAGCTGGTGACCGGAGGGGTCTTCTACTGCCTGGGCATGGTCTTCTTCAAGAG
TGACGGGAGGATCCCCTTTGCCCACGCCATCTGGCATCTCTTTGTAGCATTTGGTGCTGGTACCCACTACTATGCCATCTGGAGGTACCT
CTATCTGCCCAGCACCCTGCAGACCAAGGTGTCCAAATGAGGTGACCCAGACTTGAGAGGTCGTTTGGGCTTTAGGAGTGGAGCACGTTT
CTGTGAACGTTAACCCAGAGCACAGCGCCAAGGCCTGTCTTCCCTTTATTGGGTAGAGTTCTTGATGGCTCCAAGGTGACTTCTGGTGAC
AGCCAGATCATCCCTCGAGTCCCCAGCGAGAAAGAAAGCATTTAGCCATTCTTACAGAGGAGAAATTAACCCTGTAATGTGTTTCTATTT
TAGATGAGTGTTTCCTAATACAAGCAACATTAACATCTTCAGAAAAGGAAGCAGGCATGGTCCTGGAAAATTGGGGAATGACGGGCCAAT
CTGTGTTTCCTAAGGTCCTGAAGAATCTGGCAAAGAGTCCTGTGGGTTGTTTATACCTGGGTGGCCAGGGCCTCCCTCTCTGTTACCAAA
GTCCAGGCTGGCGAATTGTCTCTGGTTCAGGGAAAGGGGACAGCCCAGCTTGAAGATGAGGGATGGTGAATGGCTGTGACCATGGCAGAC
ATCACCAATCAAGTGCAGCACATGGGTGATGTCAGAATTCTTCCCAGCACAGTGTTCTGGGCAGCCAGTACCAATCAATTTGGCACTCAT
GATGGGACCTCTTTGCCCTTCCTGTCTGGTGTGCTCTGAAATGGGATAATGGCCAGAGTAGCTGAAAATCTCCAAATGGGCATTTGCATG
CCTATCTCCTCATCTCCCCCTCCCTTTTGGGAAACTCCTGGAGTAGGCAGTTTGGGGGCGGTAGAGGGAAACTGAGGCGCACACCCATGC
AGCCCCTGATGTTCTGTTCCACCGTAGTTGATTCTCAGTAGAGTTGGGAATGAGGATGCTGTTACTTGGCCATTTCTTCCCATCTCCAAA
AATCCAGAGACATTACGAGAGCTATTCATTCATAAGATGGGGCAAACAGCCCCCAGGCACTTGCTCCCTGCTCCATACTTAAGGTTTGTG
ATGCCAACATTTGGATTCTCTCTTGGTGCCAATCAGTGGCTGTTAGAGGCTACTCAGGTGTACCCCAAACAGAAGGCACATGGATCTGGG
GCGACTGTTCCAGGTCCTCCCAACCTCTGAAGTGCTCAGTAGCCCAACAACAAGGCTGCTGGGGGCCTGTTCTTCAGCCCCCGTCAGGGC
GGGGCCAGCCTCTCTGTCCAATGCTGCCTGGACATTTACTGGGGAGGTGAGTAGCAGGCCCAGCTCCAGGATCTGAATTGGAATCTCAGA
TTCTCTGGATAAAGAATCTGTCTCAAGTCAGGAGGTCCTCATTCTGCGACTCCCAACCAGGGTGGAGTGGGCACAGACAGGATGCCTTAT

>12040_12040_1_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397098_MMD2_chr7_4965163_ENST00000401401_length(amino acids)=243AA_BP=12
MRLHQVAKEPAPRFMNHRVPAHKRYQPTEYEHAANCATHAFWIIPSILGSSNLYFLSDDDWETISAWIYGLGLCGLFVVSTVFHTISWKK
SHLRMVEHCLHMFDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASVGTIYVFFFHERYKLVELLCYVVMGFFPALVILSMPNTE

--------------------------------------------------------------
>12040_12040_2_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397098_MMD2_chr7_4965163_ENST00000404774_length(transcript)=3229nt_BP=1056nt
GCGACGCAGCTGTTCACGCTTAGGTGGGCGACGTGGGCGCAGGTGGGCGCAGGTAGGCGCGTGGGGCGGCGGCGGGGTGGCCGGCGGGTC
AGGGCGCCAGGAGACCCAGAGCCCCGGGGCGGGCTCCCGCGGGGCTCCGCCCCCTCCACGTGGGTGCGCGGAGGCCCGGCGCGGCGCGAC
CGGGCGGCGGCCCTGGGGTCCGCGGTGCTGGGGAGGCTGGTGCGGCCGGTGCGGCCGGTGCGTCCCGGCGCGGGCTCCGACACCCGCACC
CGCCTCTGGGTTAACTCAGCGCGGGCGAGTGGAAGGGACTCAGCTGGCTCCTAGGTTTCAGGCCGTCAGGGCTTGCAGTGGCTCTGGTTT
CATTGTCTTTCTCTGAAGACGCCCTGATTGCCCTCCGAGGCTTTCAGCTCCCACTTTCTCTTTTTCAATTTTTGAGGCAGTGTCTCGCTG
TGCCACCCAGGCTGGAGTGCAATGGCGTGATCATAGCTCACTGCAGCCTCCACCTCCTGGGCTCAAGCCGTCCTCCCGCCTCATCCTCCC
AAGTAGCTGGGACCACATGCGCGCGCCACCACACCCGGATAATTTTTAAAAATGTTTTTTGTAGAAATGGGGTCTCACCATGTTACCCAG
GCTGGTCTCGAATTCTTGGGCTCAAGCGATGGATCCTCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCAACGCGCTTG
GCCTCACTTTCCATCATAAGCATGCTTTCCGTTTCCTTCCTTCCGTCATTCATTCATTCATTTTTAAAAAACGTTCATTGGGTTCCTCCT
GCACTGTTCGGGGCATTGGGCTACAGCTGTCAACAAGTGGAGACAAGTCTGTGATCTAGTGAACTTCCATTCTGGAGGGGAGAGACAGAT
GAACAAGGTGCACAGAGCAGGTGATGGATGGCAAAACAGAAGAGAAAAGTTCCTGAAGTGACAGAGAAAAAGAACAAAAAGCTGAAGAAG
GCGTCAGCAGAGGGGCCACTGCTGGGCCCTGAGGCTGCACCAAGTGGCGAAGGAGCCGGCTCCAAGGTTCATGAACCACCGAGTCCCTGC
CCACAAGAGGTACCAGCCCACAGAGTATGAACATGCGGCCAACTGTGCCACCCATGCTTTCTGGATCATCCCCAGCATCCTGGGCAGCTC
CAACCTCTACTTCCTGTCGGACGATGACTGGGAGACCATCTCTGCCTGGATCTACGGCCTCGGCCTCTGCGGCCTCTTCGTGGTGTCCAC
TGTGTTTCACACCATCTCCTGGAAGAAGAGCCACCTCAGGATGGTGGAACACTGTCTACACATGTTCGACCGGATGGTCATCTATTTCTT
CATAGCGGCTTCCTACGCACCCTGGCTGAACCTTCGGGAGCTGGGCCCCTGGGCCTCCCACATGCGCTGGCTGGTCTGGATTATGGCTTC
CGTGGGCACCATCTATGTCTTCTTCTTCCATGAGCGAACAGGGAGCTGTGTGCAGTTTCTTCGTGGGGAGGCATGTCCTAAGGCCGGCAC
GGCTTGTCTTCCTGCCAGGTACAAGCTTGTGGAGCTTCTCTGCTACGTCGTAATGGGCTTCTTCCCCGCCCTGGTCATCCTCTCCATGCC
CAACACCGAGGGCATCTGGGAGCTGGTGACCGGAGGGGTCTTCTACTGCCTGGGCATGGTCTTCTTCAAGAGTGACGGGAGGATCCCCTT
TGCCCACGCCATCTGGCATCTCTTTGTAGCATTTGGTGCTGGTACCCACTACTATGCCATCTGGAGGTACCTCTATCTGCCCAGCACCCT
GCAGACCAAGGTGTCCAAATGAGGTGACCCAGACTTGAGAGGTCGTTTGGGCTTTAGGAGTGGAGCACGTTTCTGTGAACGTTAACCCAG
AGCACAGCGCCAAGGCCTGTCTTCCCTTTATTGGGTAGAGTTCTTGATGGCTCCAAGGTGACTTCTGGTGACAGCCAGATCATCCCTCGA
GTCCCCAGCGAGAAAGAAAGCATTTAGCCATTCTTACAGAGGAGAAATTAACCCTGTAATGTGTTTCTATTTTAGATGAGTGTTTCCTAA
TACAAGCAACATTAACATCTTCAGAAAAGGAAGCAGGCATGGTCCTGGAAAATTGGGGAATGACGGGCCAATCTGTGTTTCCTAAGGTCC
TGAAGAATCTGGCAAAGAGTCCTGTGGGTTGTTTATACCTGGGTGGCCAGGGCCTCCCTCTCTGTTACCAAAGTCCAGGCTGGCGAATTG
TCTCTGGTTCAGGGAAAGGGGACAGCCCAGCTTGAAGATGAGGGATGGTGAATGGCTGTGACCATGGCAGACATCACCAATCAAGTGCAG
CACATGGGTGATGTCAGAATTCTTCCCAGCACAGTGTTCTGGGCAGCCAGTACCAATCAATTTGGCACTCATGATGGGACCTCTTTGCCC
TTCCTGTCTGGTGTGCTCTGAAATGGGATAATGGCCAGAGTAGCTGAAAATCTCCAAATGGGCATTTGCATGCCTATCTCCTCATCTCCC
CCTCCCTTTTGGGAAACTCCTGGAGTAGGCAGTTTGGGGGCGGTAGAGGGAAACTGAGGCGCACACCCATGCAGCCCCTGATGTTCTGTT
CCACCGTAGTTGATTCTCAGTAGAGTTGGGAATGAGGATGCTGTTACTTGGCCATTTCTTCCCATCTCCAAAAATCCAGAGACATTACGA
GAGCTATTCATTCATAAGATGGGGCAAACAGCCCCCAGGCACTTGCTCCCTGCTCCATACTTAAGGTTTGTGATGCCAACATTTGGATTC
TCTCTTGGTGCCAATCAGTGGCTGTTAGAGGCTACTCAGGTGTACCCCAAACAGAAGGCACATGGATCTGGGGCGACTGTTCCAGGTCCT
CCCAACCTCTGAAGTGCTCAGTAGCCCAACAACAAGGCTGCTGGGGGCCTGTTCTTCAGCCCCCGTCAGGGCGGGGCCAGCCTCTCTGTC
CAATGCTGCCTGGACATTTACTGGGGAGGTGAGTAGCAGGCCCAGCTCCAGGATCTGAATTGGAATCTCAGATTCTCTGGATAAAGAATC
TGTCTCAAGTCAGGAGGTCCTCATTCTGCGACTCCCAACCAGGGTGGAGTGGGCACAGACAGGATGCCTTATGCTTATCTCTAGCACATT

>12040_12040_2_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397098_MMD2_chr7_4965163_ENST00000404774_length(amino acids)=267AA_BP=12
MRLHQVAKEPAPRFMNHRVPAHKRYQPTEYEHAANCATHAFWIIPSILGSSNLYFLSDDDWETISAWIYGLGLCGLFVVSTVFHTISWKK
SHLRMVEHCLHMFDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASVGTIYVFFFHERTGSCVQFLRGEACPKAGTACLPARYKL

--------------------------------------------------------------
>12040_12040_3_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397100_MMD2_chr7_4965163_ENST00000401401_length(transcript)=2262nt_BP=170nt
GCCGGAAGGCGGCGTCCGCGACGCAGCTGTTCACGCTTAGGATGGCAAAACAGAAGAGAAAAGTTCCTGAAGTGACAGAGAAAAAGAACA
AAAAGCTGAAGAAGGCGTCAGCAGAGGGGCCACTGCTGGGCCCTGAGGCTGCACCAAGTGGCGAAGGAGCCGGCTCCAAGGTTCATGAAC
CACCGAGTCCCTGCCCACAAGAGGTACCAGCCCACAGAGTATGAACATGCGGCCAACTGTGCCACCCATGCTTTCTGGATCATCCCCAGC
ATCCTGGGCAGCTCCAACCTCTACTTCCTGTCGGACGATGACTGGGAGACCATCTCTGCCTGGATCTACGGCCTCGGCCTCTGCGGCCTC
TTCGTGGTGTCCACTGTGTTTCACACCATCTCCTGGAAGAAGAGCCACCTCAGGATGGTGGAACACTGTCTACACATGTTCGACCGGATG
GTCATCTATTTCTTCATAGCGGCTTCCTACGCACCCTGGCTGAACCTTCGGGAGCTGGGCCCCTGGGCCTCCCACATGCGCTGGCTGGTC
TGGATTATGGCTTCCGTGGGCACCATCTATGTCTTCTTCTTCCATGAGCGGTACAAGCTTGTGGAGCTTCTCTGCTACGTCGTAATGGGC
TTCTTCCCCGCCCTGGTCATCCTCTCCATGCCCAACACCGAGGGCATCTGGGAGCTGGTGACCGGAGGGGTCTTCTACTGCCTGGGCATG
GTCTTCTTCAAGAGTGACGGGAGGATCCCCTTTGCCCACGCCATCTGGCATCTCTTTGTAGCATTTGGTGCTGGTACCCACTACTATGCC
ATCTGGAGGTACCTCTATCTGCCCAGCACCCTGCAGACCAAGGTGTCCAAATGAGGTGACCCAGACTTGAGAGGTCGTTTGGGCTTTAGG
AGTGGAGCACGTTTCTGTGAACGTTAACCCAGAGCACAGCGCCAAGGCCTGTCTTCCCTTTATTGGGTAGAGTTCTTGATGGCTCCAAGG
TGACTTCTGGTGACAGCCAGATCATCCCTCGAGTCCCCAGCGAGAAAGAAAGCATTTAGCCATTCTTACAGAGGAGAAATTAACCCTGTA
ATGTGTTTCTATTTTAGATGAGTGTTTCCTAATACAAGCAACATTAACATCTTCAGAAAAGGAAGCAGGCATGGTCCTGGAAAATTGGGG
AATGACGGGCCAATCTGTGTTTCCTAAGGTCCTGAAGAATCTGGCAAAGAGTCCTGTGGGTTGTTTATACCTGGGTGGCCAGGGCCTCCC
TCTCTGTTACCAAAGTCCAGGCTGGCGAATTGTCTCTGGTTCAGGGAAAGGGGACAGCCCAGCTTGAAGATGAGGGATGGTGAATGGCTG
TGACCATGGCAGACATCACCAATCAAGTGCAGCACATGGGTGATGTCAGAATTCTTCCCAGCACAGTGTTCTGGGCAGCCAGTACCAATC
AATTTGGCACTCATGATGGGACCTCTTTGCCCTTCCTGTCTGGTGTGCTCTGAAATGGGATAATGGCCAGAGTAGCTGAAAATCTCCAAA
TGGGCATTTGCATGCCTATCTCCTCATCTCCCCCTCCCTTTTGGGAAACTCCTGGAGTAGGCAGTTTGGGGGCGGTAGAGGGAAACTGAG
GCGCACACCCATGCAGCCCCTGATGTTCTGTTCCACCGTAGTTGATTCTCAGTAGAGTTGGGAATGAGGATGCTGTTACTTGGCCATTTC
TTCCCATCTCCAAAAATCCAGAGACATTACGAGAGCTATTCATTCATAAGATGGGGCAAACAGCCCCCAGGCACTTGCTCCCTGCTCCAT
ACTTAAGGTTTGTGATGCCAACATTTGGATTCTCTCTTGGTGCCAATCAGTGGCTGTTAGAGGCTACTCAGGTGTACCCCAAACAGAAGG
CACATGGATCTGGGGCGACTGTTCCAGGTCCTCCCAACCTCTGAAGTGCTCAGTAGCCCAACAACAAGGCTGCTGGGGGCCTGTTCTTCA
GCCCCCGTCAGGGCGGGGCCAGCCTCTCTGTCCAATGCTGCCTGGACATTTACTGGGGAGGTGAGTAGCAGGCCCAGCTCCAGGATCTGA
ATTGGAATCTCAGATTCTCTGGATAAAGAATCTGTCTCAAGTCAGGAGGTCCTCATTCTGCGACTCCCAACCAGGGTGGAGTGGGCACAG
ACAGGATGCCTTATGCTTATCTCTAGCACATTCCAGGGGGTTCCAGGGTTCCTGCACCTGGAATCCAGTGTGTCCAAGCCAGTATTAAAT

>12040_12040_3_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397100_MMD2_chr7_4965163_ENST00000401401_length(amino acids)=243AA_BP=12
MRLHQVAKEPAPRFMNHRVPAHKRYQPTEYEHAANCATHAFWIIPSILGSSNLYFLSDDDWETISAWIYGLGLCGLFVVSTVFHTISWKK
SHLRMVEHCLHMFDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASVGTIYVFFFHERYKLVELLCYVVMGFFPALVILSMPNTE

--------------------------------------------------------------
>12040_12040_4_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397100_MMD2_chr7_4965163_ENST00000404774_length(transcript)=2343nt_BP=170nt
GCCGGAAGGCGGCGTCCGCGACGCAGCTGTTCACGCTTAGGATGGCAAAACAGAAGAGAAAAGTTCCTGAAGTGACAGAGAAAAAGAACA
AAAAGCTGAAGAAGGCGTCAGCAGAGGGGCCACTGCTGGGCCCTGAGGCTGCACCAAGTGGCGAAGGAGCCGGCTCCAAGGTTCATGAAC
CACCGAGTCCCTGCCCACAAGAGGTACCAGCCCACAGAGTATGAACATGCGGCCAACTGTGCCACCCATGCTTTCTGGATCATCCCCAGC
ATCCTGGGCAGCTCCAACCTCTACTTCCTGTCGGACGATGACTGGGAGACCATCTCTGCCTGGATCTACGGCCTCGGCCTCTGCGGCCTC
TTCGTGGTGTCCACTGTGTTTCACACCATCTCCTGGAAGAAGAGCCACCTCAGGATGGTGGAACACTGTCTACACATGTTCGACCGGATG
GTCATCTATTTCTTCATAGCGGCTTCCTACGCACCCTGGCTGAACCTTCGGGAGCTGGGCCCCTGGGCCTCCCACATGCGCTGGCTGGTC
TGGATTATGGCTTCCGTGGGCACCATCTATGTCTTCTTCTTCCATGAGCGAACAGGGAGCTGTGTGCAGTTTCTTCGTGGGGAGGCATGT
CCTAAGGCCGGCACGGCTTGTCTTCCTGCCAGGTACAAGCTTGTGGAGCTTCTCTGCTACGTCGTAATGGGCTTCTTCCCCGCCCTGGTC
ATCCTCTCCATGCCCAACACCGAGGGCATCTGGGAGCTGGTGACCGGAGGGGTCTTCTACTGCCTGGGCATGGTCTTCTTCAAGAGTGAC
GGGAGGATCCCCTTTGCCCACGCCATCTGGCATCTCTTTGTAGCATTTGGTGCTGGTACCCACTACTATGCCATCTGGAGGTACCTCTAT
CTGCCCAGCACCCTGCAGACCAAGGTGTCCAAATGAGGTGACCCAGACTTGAGAGGTCGTTTGGGCTTTAGGAGTGGAGCACGTTTCTGT
GAACGTTAACCCAGAGCACAGCGCCAAGGCCTGTCTTCCCTTTATTGGGTAGAGTTCTTGATGGCTCCAAGGTGACTTCTGGTGACAGCC
AGATCATCCCTCGAGTCCCCAGCGAGAAAGAAAGCATTTAGCCATTCTTACAGAGGAGAAATTAACCCTGTAATGTGTTTCTATTTTAGA
TGAGTGTTTCCTAATACAAGCAACATTAACATCTTCAGAAAAGGAAGCAGGCATGGTCCTGGAAAATTGGGGAATGACGGGCCAATCTGT
GTTTCCTAAGGTCCTGAAGAATCTGGCAAAGAGTCCTGTGGGTTGTTTATACCTGGGTGGCCAGGGCCTCCCTCTCTGTTACCAAAGTCC
AGGCTGGCGAATTGTCTCTGGTTCAGGGAAAGGGGACAGCCCAGCTTGAAGATGAGGGATGGTGAATGGCTGTGACCATGGCAGACATCA
CCAATCAAGTGCAGCACATGGGTGATGTCAGAATTCTTCCCAGCACAGTGTTCTGGGCAGCCAGTACCAATCAATTTGGCACTCATGATG
GGACCTCTTTGCCCTTCCTGTCTGGTGTGCTCTGAAATGGGATAATGGCCAGAGTAGCTGAAAATCTCCAAATGGGCATTTGCATGCCTA
TCTCCTCATCTCCCCCTCCCTTTTGGGAAACTCCTGGAGTAGGCAGTTTGGGGGCGGTAGAGGGAAACTGAGGCGCACACCCATGCAGCC
CCTGATGTTCTGTTCCACCGTAGTTGATTCTCAGTAGAGTTGGGAATGAGGATGCTGTTACTTGGCCATTTCTTCCCATCTCCAAAAATC
CAGAGACATTACGAGAGCTATTCATTCATAAGATGGGGCAAACAGCCCCCAGGCACTTGCTCCCTGCTCCATACTTAAGGTTTGTGATGC
CAACATTTGGATTCTCTCTTGGTGCCAATCAGTGGCTGTTAGAGGCTACTCAGGTGTACCCCAAACAGAAGGCACATGGATCTGGGGCGA
CTGTTCCAGGTCCTCCCAACCTCTGAAGTGCTCAGTAGCCCAACAACAAGGCTGCTGGGGGCCTGTTCTTCAGCCCCCGTCAGGGCGGGG
CCAGCCTCTCTGTCCAATGCTGCCTGGACATTTACTGGGGAGGTGAGTAGCAGGCCCAGCTCCAGGATCTGAATTGGAATCTCAGATTCT
CTGGATAAAGAATCTGTCTCAAGTCAGGAGGTCCTCATTCTGCGACTCCCAACCAGGGTGGAGTGGGCACAGACAGGATGCCTTATGCTT
ATCTCTAGCACATTCCAGGGGGTTCCAGGGTTCCTGCACCTGGAATCCAGTGTGTCCAAGCCAGTATTAAATTATCTCAACACATTCCAC

>12040_12040_4_C7orf50-MMD2_C7orf50_chr7_1166893_ENST00000397100_MMD2_chr7_4965163_ENST00000404774_length(amino acids)=267AA_BP=12
MRLHQVAKEPAPRFMNHRVPAHKRYQPTEYEHAANCATHAFWIIPSILGSSNLYFLSDDDWETISAWIYGLGLCGLFVVSTVFHTISWKK
SHLRMVEHCLHMFDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASVGTIYVFFFHERTGSCVQFLRGEACPKAGTACLPARYKL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C7orf50-MMD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C7orf50-MMD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C7orf50-MMD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource