![]() |
||||||
|
![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ACBD6-CCDC122 (FusionGDB2 ID:HG84320TG160857) |
Fusion Gene Summary for ACBD6-CCDC122 |
![]() |
Fusion gene information | Fusion gene name: ACBD6-CCDC122 | Fusion gene ID: hg84320tg160857 | Hgene | Tgene | Gene symbol | ACBD6 | CCDC122 | Gene ID | 84320 | 160857 |
Gene name | acyl-CoA binding domain containing 6 | coiled-coil domain containing 122 | |
Synonyms | - | - | |
Cytomap | ('ACBD6')('CCDC122') 1q25.2-q25.3 | 13q14.11 | |
Type of gene | protein-coding | protein-coding | |
Description | acyl-CoA-binding domain-containing protein 6acyl-Coenzyme A binding domain containing 6 | coiled-coil domain-containing protein 122 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9BR61 | Q5T0U0 | |
Ensembl transtripts involved in fusion gene | ENST00000367595, ENST00000475338, | ||
Fusion gene scores | * DoF score | 11 X 9 X 7=693 | 3 X 2 X 2=12 |
# samples | 11 | 3 | |
** MAII score | log2(11/693*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ACBD6 [Title/Abstract] AND CCDC122 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ACBD6(180283827)-CCDC122(44411565), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-IS-A3K6-01A | ACBD6 | chr1 | 180283827 | - | CCDC122 | chr13 | 44411565 | - |
Top |
Fusion Gene ORF analysis for ACBD6-CCDC122 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000367595 | ENST00000281508 | ACBD6 | chr1 | 180283827 | - | CCDC122 | chr13 | 44411565 | - |
5CDS-intron | ENST00000367595 | ENST00000476570 | ACBD6 | chr1 | 180283827 | - | CCDC122 | chr13 | 44411565 | - |
5UTR-3CDS | ENST00000475338 | ENST00000444614 | ACBD6 | chr1 | 180283827 | - | CCDC122 | chr13 | 44411565 | - |
5UTR-intron | ENST00000475338 | ENST00000281508 | ACBD6 | chr1 | 180283827 | - | CCDC122 | chr13 | 44411565 | - |
5UTR-intron | ENST00000475338 | ENST00000476570 | ACBD6 | chr1 | 180283827 | - | CCDC122 | chr13 | 44411565 | - |
Frame-shift | ENST00000367595 | ENST00000444614 | ACBD6 | chr1 | 180283827 | - | CCDC122 | chr13 | 44411565 | - |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for ACBD6-CCDC122 |
![]() |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Top |
Fusion Protein Features for ACBD6-CCDC122 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:180283827/:44411565) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
ACBD6 | CCDC122 |
FUNCTION: Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. {ECO:0000269|PubMed:18268358}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for ACBD6-CCDC122 |
![]() |
Top |
Fusion Gene PPI Analysis for ACBD6-CCDC122 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for ACBD6-CCDC122 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for ACBD6-CCDC122 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACBD6 | C0020796 | Profound Mental Retardation | 1 | CTD_human |
Hgene | ACBD6 | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human |
Hgene | ACBD6 | C0917816 | Mental deficiency | 1 | CTD_human |
Hgene | ACBD6 | C3714756 | Intellectual Disability | 1 | CTD_human;GENOMICS_ENGLAND |