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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:APOPT1-MARK3 (FusionGDB2 ID:HG84334TG4140)

Fusion Gene Summary for APOPT1-MARK3

Fusion gene summary

Fusion gene information	Fusion gene name: APOPT1-MARK3
	Fusion gene ID: hg84334tg4140
		Hgene	Tgene
	Gene symbol	APOPT1	MARK3
	Gene ID	84334	4140
	Gene name	cytochrome c oxidase assembly factor 8	microtubule affinity regulating kinase 3
	Synonyms	APOP\|APOP1\|APOPT1\|C14orf153	CTAK1\|KP78\|PAR1A\|Par-1a\|VIPB
	Cytomap	('APOPT1')('MARK3') 14q32.33	14q32.32-q32.33
	Type of gene	protein-coding	protein-coding
	Description	cytochrome c oxidase assembly factor 8UPF0671 protein C14orf153apoptogenic 1, mitochondrial	MAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000477116, ENST00000556253, ENST00000247618, ENST00000409074,
Fusion gene scores	* DoF score	5 X 5 X 4=100	16 X 19 X 9=2736
	# samples	8	21
	** MAII score	log2(8/100*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/2736*10)=-3.70360699721978 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: APOPT1 [Title/Abstract] AND MARK3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	APOPT1(104040507)-MARK3(103941330), # samples:2 APOPT1(104029461)-MARK3(103958114), # samples:2
Anticipated loss of major functional domain due to fusion event.	APOPT1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APOPT1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APOPT1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. APOPT1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. APOPT1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. APOPT1-MARK3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. APOPT1-MARK3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. APOPT1-MARK3 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	APOPT1	GO:0000302	response to reactive oxygen species	30552096
Hgene	APOPT1	GO:0033617	mitochondrial respiratory chain complex IV assembly	30552096
Hgene	APOPT1	GO:0050821	protein stabilization	30552096
Hgene	APOPT1	GO:1904960	positive regulation of cytochrome-c oxidase activity	30552096
Tgene	MARK3	GO:0018105	peptidyl-serine phosphorylation	9543386
Tgene	MARK3	GO:0032092	positive regulation of protein binding	9543386
Tgene	MARK3	GO:0035331	negative regulation of hippo signaling	28087714
Tgene	MARK3	GO:0036289	peptidyl-serine autophosphorylation	9543386

Fusion gene breakpoints across APOPT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MARK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-38-4630-01A	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
ChimerDB4	LUAD	TCGA-38-4630-01A	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
ChimerDB4	LUAD	TCGA-38-4630-01A	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
ChimerDB4	LUAD	TCGA-38-4630-01A	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
ChimerDB4	LUAD	TCGA-38-4630	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
ChimerDB4	LUAD	TCGA-64-1680-01A	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
ChimerDB4	UCEC	TCGA-AX-A2H4-01A	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+

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Fusion Gene ORF analysis for APOPT1-MARK3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000477116	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
3UTR-3CDS	ENST00000477116	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000216288	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
3UTR-3CDS	ENST00000477116	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
3UTR-3CDS	ENST00000477116	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
3UTR-3CDS	ENST00000477116	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000303622	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
3UTR-3CDS	ENST00000477116	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
3UTR-3CDS	ENST00000477116	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000335102	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
3UTR-3CDS	ENST00000477116	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
3UTR-3CDS	ENST00000477116	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
3UTR-3CDS	ENST00000477116	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000416682	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
3UTR-3CDS	ENST00000477116	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
3UTR-3CDS	ENST00000477116	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
3UTR-3CDS	ENST00000477116	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000429436	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
3UTR-3CDS	ENST00000477116	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
3UTR-3CDS	ENST00000477116	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
3UTR-3CDS	ENST00000477116	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000440884	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
3UTR-3CDS	ENST00000477116	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
3UTR-3CDS	ENST00000477116	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000553942	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000477116	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
3UTR-3CDS	ENST00000556253	ENST00000216288	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000556253	ENST00000303622	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000556253	ENST00000335102	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000556253	ENST00000416682	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000556253	ENST00000429436	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000556253	ENST00000440884	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3CDS	ENST00000556253	ENST00000553942	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3UTR	ENST00000477116	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
3UTR-3UTR	ENST00000477116	ENST00000561071	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-3UTR	ENST00000556253	ENST00000561071	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
3UTR-intron	ENST00000477116	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
3UTR-intron	ENST00000477116	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
3UTR-intron	ENST00000477116	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
3UTR-intron	ENST00000477116	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
3UTR-intron	ENST00000477116	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
3UTR-intron	ENST00000477116	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
5CDS-3UTR	ENST00000247618	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
5CDS-3UTR	ENST00000247618	ENST00000561071	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
5CDS-3UTR	ENST00000247618	ENST00000561071	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
5CDS-3UTR	ENST00000247618	ENST00000561071	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
5CDS-3UTR	ENST00000409074	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
5CDS-3UTR	ENST00000409074	ENST00000561071	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
5CDS-3UTR	ENST00000409074	ENST00000561071	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
5CDS-3UTR	ENST00000409074	ENST00000561071	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
5CDS-3UTR	ENST00000556253	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
5CDS-3UTR	ENST00000556253	ENST00000561071	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
5CDS-3UTR	ENST00000556253	ENST00000561071	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
5CDS-intron	ENST00000247618	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
5CDS-intron	ENST00000247618	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
5CDS-intron	ENST00000247618	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
5CDS-intron	ENST00000247618	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
5CDS-intron	ENST00000247618	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
5CDS-intron	ENST00000247618	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
5CDS-intron	ENST00000409074	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
5CDS-intron	ENST00000409074	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
5CDS-intron	ENST00000409074	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
5CDS-intron	ENST00000409074	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
5CDS-intron	ENST00000409074	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
5CDS-intron	ENST00000409074	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
5CDS-intron	ENST00000556253	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
5CDS-intron	ENST00000556253	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
5CDS-intron	ENST00000556253	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
5CDS-intron	ENST00000556253	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
5CDS-intron	ENST00000556253	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
5CDS-intron	ENST00000556253	ENST00000561071	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
Frame-shift	ENST00000247618	ENST00000216288	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000216288	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000216288	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000247618	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
Frame-shift	ENST00000247618	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000303622	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000303622	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000247618	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000335102	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000335102	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000247618	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
Frame-shift	ENST00000247618	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000416682	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000416682	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000247618	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
Frame-shift	ENST00000247618	ENST00000429436	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000429436	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000429436	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000247618	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
Frame-shift	ENST00000247618	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000440884	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000440884	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000247618	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000553942	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000247618	ENST00000553942	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000409074	ENST00000216288	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000216288	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000216288	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000409074	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
Frame-shift	ENST00000409074	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000303622	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000303622	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000409074	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000335102	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000335102	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000409074	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
Frame-shift	ENST00000409074	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000416682	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000416682	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000409074	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
Frame-shift	ENST00000409074	ENST00000429436	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000429436	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000429436	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000409074	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
Frame-shift	ENST00000409074	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000440884	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000440884	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000409074	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000553942	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000409074	ENST00000553942	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000556253	ENST00000216288	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000556253	ENST00000216288	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000556253	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
Frame-shift	ENST00000556253	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000556253	ENST00000303622	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000556253	ENST00000303622	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000556253	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000556253	ENST00000335102	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000556253	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
Frame-shift	ENST00000556253	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000556253	ENST00000416682	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000556253	ENST00000416682	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000556253	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
Frame-shift	ENST00000556253	ENST00000429436	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000556253	ENST00000429436	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000556253	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103934370	+
Frame-shift	ENST00000556253	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000556253	ENST00000440884	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000556253	ENST00000440884	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
Frame-shift	ENST00000556253	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
Frame-shift	ENST00000556253	ENST00000553942	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
In-frame	ENST00000247618	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000247618	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
In-frame	ENST00000247618	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000247618	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000247618	ENST00000303622	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
In-frame	ENST00000247618	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000247618	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000247618	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000247618	ENST00000335102	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
In-frame	ENST00000247618	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000247618	ENST00000416682	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
In-frame	ENST00000247618	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000247618	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000247618	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
In-frame	ENST00000247618	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000247618	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000247618	ENST00000440884	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
In-frame	ENST00000247618	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000247618	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000247618	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000247618	ENST00000553942	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
In-frame	ENST00000409074	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000409074	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
In-frame	ENST00000409074	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000409074	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000409074	ENST00000303622	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
In-frame	ENST00000409074	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000409074	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000409074	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000409074	ENST00000335102	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
In-frame	ENST00000409074	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000409074	ENST00000416682	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
In-frame	ENST00000409074	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000409074	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000409074	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
In-frame	ENST00000409074	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000409074	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000409074	ENST00000440884	APOPT1	chr14	104053701	+	MARK3	chr14	103969219	+
In-frame	ENST00000409074	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000409074	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000409074	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000409074	ENST00000553942	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
In-frame	ENST00000556253	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000556253	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
In-frame	ENST00000556253	ENST00000216288	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000556253	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000556253	ENST00000303622	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000556253	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000556253	ENST00000335102	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000556253	ENST00000335102	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
In-frame	ENST00000556253	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000556253	ENST00000416682	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000556253	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000556253	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103969219	+
In-frame	ENST00000556253	ENST00000429436	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000556253	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000556253	ENST00000440884	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000556253	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103941330	+
In-frame	ENST00000556253	ENST00000553942	APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+
In-frame	ENST00000556253	ENST00000553942	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
intron-3CDS	ENST00000477116	ENST00000216288	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
intron-3CDS	ENST00000477116	ENST00000216288	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
intron-3CDS	ENST00000477116	ENST00000303622	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
intron-3CDS	ENST00000477116	ENST00000303622	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
intron-3CDS	ENST00000477116	ENST00000335102	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
intron-3CDS	ENST00000477116	ENST00000335102	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
intron-3CDS	ENST00000477116	ENST00000416682	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
intron-3CDS	ENST00000477116	ENST00000416682	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
intron-3CDS	ENST00000477116	ENST00000429436	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
intron-3CDS	ENST00000477116	ENST00000429436	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
intron-3CDS	ENST00000477116	ENST00000440884	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
intron-3CDS	ENST00000477116	ENST00000440884	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
intron-3CDS	ENST00000477116	ENST00000553942	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
intron-3CDS	ENST00000477116	ENST00000553942	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+
intron-3UTR	ENST00000477116	ENST00000561071	APOPT1	chr14	104029461	+	MARK3	chr14	103969219	+
intron-3UTR	ENST00000477116	ENST00000561071	APOPT1	chr14	104029461	+	MARK3	chr14	103958114	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for APOPT1-MARK3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
APOPT1	chr14	104053701	+	MARK3	chr14	103969218	+	0.000269092	0.9997309
APOPT1	chr14	104040507	+	MARK3	chr14	103969218	+	0.000167556	0.9998324
APOPT1	chr14	104029461	+	MARK3	chr14	103969218	+	0.000122365	0.9998776
APOPT1	chr14	104029461	+	MARK3	chr14	103958113	+	1.74E-06	0.9999982
APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+	7.58E-07	0.9999993
APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+	7.58E-07	0.9999993
APOPT1	chr14	104040507	+	MARK3	chr14	103934369	+	4.86E-07	0.9999995
APOPT1	chr14	104053701	+	MARK3	chr14	103969218	+	0.000269092	0.9997309
APOPT1	chr14	104040507	+	MARK3	chr14	103969218	+	0.000167556	0.9998324
APOPT1	chr14	104029461	+	MARK3	chr14	103969218	+	0.000122365	0.9998776
APOPT1	chr14	104029461	+	MARK3	chr14	103958113	+	1.74E-06	0.9999982
APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+	7.58E-07	0.9999993
APOPT1	chr14	104040507	+	MARK3	chr14	103941329	+	7.58E-07	0.9999993
APOPT1	chr14	104040507	+	MARK3	chr14	103934369	+	4.86E-07	0.9999995

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for APOPT1-MARK3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:104040507/chr14:103941330)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000216288

704_753

598

714.0

Domain

KA1

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000303622

704_753

614

730.0

Domain

KA1

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000416682

704_753

637

753.0

Domain

KA1

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000429436

704_753

638

754.0

Domain

KA1

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000440884

704_753

544

660.0

Domain

KA1

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000553942

704_753

629

745.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000216288

704_753

405

714.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000303622

704_753

421

730.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000416682

704_753

444

753.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000429436

704_753

421

754.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000440884

704_753

342

660.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000553942

704_753

421

745.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000216288

704_753

405

714.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000303622

704_753

421

730.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000416682

704_753

444

753.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000429436

704_753

421

754.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000440884

704_753

342

660.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000553942

704_753

421

745.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000216288

704_753

598

714.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000303622

704_753

614

730.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000416682

704_753

637

753.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000429436

704_753

638

754.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000440884

704_753

544

660.0

Domain

KA1

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000553942

704_753

629

745.0

Domain

KA1

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000216288

704_753

598

714.0

Domain

KA1

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000303622

704_753

614

730.0

Domain

KA1

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000416682

704_753

637

753.0

Domain

KA1

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000429436

704_753

638

754.0

Domain

KA1

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000440884

704_753

544

660.0

Domain

KA1

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000553942

704_753

629

745.0

Domain

KA1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000216288

326_365

598

714.0

Domain

UBA

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000216288

56_307

598

714.0

Domain

Protein kinase

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000303622

326_365

614

730.0

Domain

UBA

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000303622

56_307

614

730.0

Domain

Protein kinase

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000416682

326_365

637

753.0

Domain

UBA

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000416682

56_307

637

753.0

Domain

Protein kinase

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000429436

326_365

638

754.0

Domain

UBA

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000429436

56_307

638

754.0

Domain

Protein kinase

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000440884

326_365

544

660.0

Domain

UBA

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000440884

56_307

544

660.0

Domain

Protein kinase

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000553942

326_365

629

745.0

Domain

UBA

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000553942

56_307

629

745.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000216288

326_365

405

714.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000216288

56_307

405

714.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000303622

326_365

421

730.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000303622

56_307

421

730.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000416682

326_365

444

753.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000416682

56_307

444

753.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000429436

326_365

421

754.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000429436

56_307

421

754.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000440884

326_365

342

660.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000440884

56_307

342

660.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000553942

326_365

421

745.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000553942

56_307

421

745.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000216288

326_365

405

714.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000216288

56_307

405

714.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000303622

326_365

421

730.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000303622

56_307

421

730.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000416682

326_365

444

753.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000416682

56_307

444

753.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000429436

326_365

421

754.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000429436

56_307

421

754.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000440884

326_365

342

660.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000440884

56_307

342

660.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000553942

326_365

421

745.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000553942

56_307

421

745.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000216288

326_365

598

714.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000216288

56_307

598

714.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000303622

326_365

614

730.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000303622

56_307

614

730.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000416682

326_365

637

753.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000416682

56_307

637

753.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000429436

326_365

638

754.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000429436

56_307

638

754.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000440884

326_365

544

660.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000440884

56_307

544

660.0

Domain

Protein kinase

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000553942

326_365

629

745.0

Domain

UBA

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000553942

56_307

629

745.0

Domain

Protein kinase

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000216288

326_365

598

714.0

Domain

UBA

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000216288

56_307

598

714.0

Domain

Protein kinase

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000303622

326_365

614

730.0

Domain

UBA

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000303622

56_307

614

730.0

Domain

Protein kinase

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000416682

326_365

637

753.0

Domain

UBA

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000416682

56_307

637

753.0

Domain

Protein kinase

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000429436

326_365

638

754.0

Domain

UBA

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000429436

56_307

638

754.0

Domain

Protein kinase

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000440884

326_365

544

660.0

Domain

UBA

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000440884

56_307

544

660.0

Domain

Protein kinase

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000553942

326_365

629

745.0

Domain

UBA

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000553942

56_307

629

745.0

Domain

Protein kinase

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000216288

62_70

598

714.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000303622

62_70

614

730.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000416682

62_70

637

753.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000429436

62_70

638

754.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000440884

62_70

544

660.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104029461

chr14:103969219

ENST00000553942

62_70

629

745.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000216288

62_70

405

714.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000303622

62_70

421

730.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000416682

62_70

444

753.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000429436

62_70

421

754.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000440884

62_70

342

660.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103941329

ENST00000553942

62_70

421

745.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000216288

62_70

405

714.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000303622

62_70

421

730.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000416682

62_70

444

753.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000429436

62_70

421

754.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000440884

62_70

342

660.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103941330

ENST00000553942

62_70

421

745.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000216288

62_70

598

714.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000303622

62_70

614

730.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000416682

62_70

637

753.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000429436

62_70

638

754.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000440884

62_70

544

660.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104040507

chr14:103969219

ENST00000553942

62_70

629

745.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000216288

62_70

598

714.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000303622

62_70

614

730.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000416682

62_70

637

753.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000429436

62_70

638

754.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000440884

62_70

544

660.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:104053701

chr14:103969219

ENST00000553942

62_70

629

745.0

Nucleotide binding

ATP

Top

Fusion Gene Sequence for APOPT1-MARK3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for APOPT1-MARK3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for APOPT1-MARK3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for APOPT1-MARK3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C4748978	VISUAL IMPAIRMENT AND PROGRESSIVE PHTHISIS BULBI	1	UNIPROT

Fusion Gene Studies in Kim Lab

Fusion gene:APOPT1-MARK3 (FusionGDB2 ID:HG84334TG4140)

Fusion Gene Summary for APOPT1-MARK3

Fusion Gene ORF analysis for APOPT1-MARK3

Fusion Genomic Features for APOPT1-MARK3

Fusion Protein Features for APOPT1-MARK3

Fusion Gene Sequence for APOPT1-MARK3

Fusion Gene PPI Analysis for APOPT1-MARK3

Related Drugs for APOPT1-MARK3

Related Diseases for APOPT1-MARK3

Fusion Gene Studies
in Kim Lab