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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APOPT1-MARK3 (FusionGDB2 ID:HG84334TG4140)

Fusion Gene Summary for APOPT1-MARK3

check button Fusion gene summary
Fusion gene informationFusion gene name: APOPT1-MARK3
Fusion gene ID: hg84334tg4140
HgeneTgene
Gene symbol

APOPT1

MARK3

Gene ID

84334

4140

Gene namecytochrome c oxidase assembly factor 8microtubule affinity regulating kinase 3
SynonymsAPOP|APOP1|APOPT1|C14orf153CTAK1|KP78|PAR1A|Par-1a|VIPB
Cytomap('APOPT1')('MARK3')

14q32.33

14q32.32-q32.33

Type of geneprotein-codingprotein-coding
Descriptioncytochrome c oxidase assembly factor 8UPF0671 protein C14orf153apoptogenic 1, mitochondrialMAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000477116, ENST00000556253, 
ENST00000247618, ENST00000409074, 
Fusion gene scores* DoF score5 X 5 X 4=10016 X 19 X 9=2736
# samples 821
** MAII scorelog2(8/100*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(21/2736*10)=-3.70360699721978
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APOPT1 [Title/Abstract] AND MARK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPOPT1(104040507)-MARK3(103941330), # samples:2
APOPT1(104029461)-MARK3(103958114), # samples:2
Anticipated loss of major functional domain due to fusion event.APOPT1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APOPT1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APOPT1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APOPT1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APOPT1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
APOPT1-MARK3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
APOPT1-MARK3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
APOPT1-MARK3 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPOPT1

GO:0000302

response to reactive oxygen species

30552096

HgeneAPOPT1

GO:0033617

mitochondrial respiratory chain complex IV assembly

30552096

HgeneAPOPT1

GO:0050821

protein stabilization

30552096

HgeneAPOPT1

GO:1904960

positive regulation of cytochrome-c oxidase activity

30552096

TgeneMARK3

GO:0018105

peptidyl-serine phosphorylation

9543386

TgeneMARK3

GO:0032092

positive regulation of protein binding

9543386

TgeneMARK3

GO:0035331

negative regulation of hippo signaling

28087714

TgeneMARK3

GO:0036289

peptidyl-serine autophosphorylation

9543386


check buttonFusion gene breakpoints across APOPT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MARK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-38-4630-01AAPOPT1chr14

104040507

+MARK3chr14

103934370

+
ChimerDB4LUADTCGA-38-4630-01AAPOPT1chr14

104040507

+MARK3chr14

103941330

+
ChimerDB4LUADTCGA-38-4630-01AAPOPT1chr14

104040507

+MARK3chr14

103969219

+
ChimerDB4LUADTCGA-38-4630-01AAPOPT1chr14

104053701

+MARK3chr14

103969219

+
ChimerDB4LUADTCGA-38-4630APOPT1chr14

104040507

+MARK3chr14

103941329

+
ChimerDB4LUADTCGA-64-1680-01AAPOPT1chr14

104029461

+MARK3chr14

103969219

+
ChimerDB4UCECTCGA-AX-A2H4-01AAPOPT1chr14

104029461

+MARK3chr14

103958114

+


Top

Fusion Gene ORF analysis for APOPT1-MARK3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000477116ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103941330

+
3UTR-3CDSENST00000477116ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000216288APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103941329

+
3UTR-3CDSENST00000477116ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103934370

+
3UTR-3CDSENST00000477116ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103941330

+
3UTR-3CDSENST00000477116ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000303622APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103941329

+
3UTR-3CDSENST00000477116ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103941330

+
3UTR-3CDSENST00000477116ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000335102APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103941329

+
3UTR-3CDSENST00000477116ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103934370

+
3UTR-3CDSENST00000477116ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103941330

+
3UTR-3CDSENST00000477116ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000416682APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103941329

+
3UTR-3CDSENST00000477116ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103934370

+
3UTR-3CDSENST00000477116ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103941330

+
3UTR-3CDSENST00000477116ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000429436APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103941329

+
3UTR-3CDSENST00000477116ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103934370

+
3UTR-3CDSENST00000477116ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103941330

+
3UTR-3CDSENST00000477116ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000440884APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103941329

+
3UTR-3CDSENST00000477116ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103941330

+
3UTR-3CDSENST00000477116ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000553942APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3CDSENST00000477116ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103941329

+
3UTR-3CDSENST00000556253ENST00000216288APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3CDSENST00000556253ENST00000303622APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3CDSENST00000556253ENST00000335102APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3CDSENST00000556253ENST00000416682APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3CDSENST00000556253ENST00000429436APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3CDSENST00000556253ENST00000440884APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3CDSENST00000556253ENST00000553942APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3UTRENST00000477116ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103969219

+
3UTR-3UTRENST00000477116ENST00000561071APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-3UTRENST00000556253ENST00000561071APOPT1chr14

104053701

+MARK3chr14

103969219

+
3UTR-intronENST00000477116ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103934370

+
3UTR-intronENST00000477116ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103934370

+
3UTR-intronENST00000477116ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103934370

+
3UTR-intronENST00000477116ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103934370

+
3UTR-intronENST00000477116ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103941330

+
3UTR-intronENST00000477116ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103941329

+
5CDS-3UTRENST00000247618ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103969219

+
5CDS-3UTRENST00000247618ENST00000561071APOPT1chr14

104053701

+MARK3chr14

103969219

+
5CDS-3UTRENST00000247618ENST00000561071APOPT1chr14

104029461

+MARK3chr14

103969219

+
5CDS-3UTRENST00000247618ENST00000561071APOPT1chr14

104029461

+MARK3chr14

103958114

+
5CDS-3UTRENST00000409074ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103969219

+
5CDS-3UTRENST00000409074ENST00000561071APOPT1chr14

104053701

+MARK3chr14

103969219

+
5CDS-3UTRENST00000409074ENST00000561071APOPT1chr14

104029461

+MARK3chr14

103969219

+
5CDS-3UTRENST00000409074ENST00000561071APOPT1chr14

104029461

+MARK3chr14

103958114

+
5CDS-3UTRENST00000556253ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103969219

+
5CDS-3UTRENST00000556253ENST00000561071APOPT1chr14

104029461

+MARK3chr14

103969219

+
5CDS-3UTRENST00000556253ENST00000561071APOPT1chr14

104029461

+MARK3chr14

103958114

+
5CDS-intronENST00000247618ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103934370

+
5CDS-intronENST00000247618ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103934370

+
5CDS-intronENST00000247618ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103934370

+
5CDS-intronENST00000247618ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103934370

+
5CDS-intronENST00000247618ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103941330

+
5CDS-intronENST00000247618ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103941329

+
5CDS-intronENST00000409074ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103934370

+
5CDS-intronENST00000409074ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103934370

+
5CDS-intronENST00000409074ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103934370

+
5CDS-intronENST00000409074ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103934370

+
5CDS-intronENST00000409074ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103941330

+
5CDS-intronENST00000409074ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103941329

+
5CDS-intronENST00000556253ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103934370

+
5CDS-intronENST00000556253ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103934370

+
5CDS-intronENST00000556253ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103934370

+
5CDS-intronENST00000556253ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103934370

+
5CDS-intronENST00000556253ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103941330

+
5CDS-intronENST00000556253ENST00000561071APOPT1chr14

104040507

+MARK3chr14

103941329

+
Frame-shiftENST00000247618ENST00000216288APOPT1chr14

104053701

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000216288APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000216288APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000247618ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103934370

+
Frame-shiftENST00000247618ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000303622APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000303622APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000247618ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000335102APOPT1chr14

104053701

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000335102APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000247618ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103934370

+
Frame-shiftENST00000247618ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000416682APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000416682APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000247618ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103934370

+
Frame-shiftENST00000247618ENST00000429436APOPT1chr14

104053701

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000429436APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000429436APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000247618ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103934370

+
Frame-shiftENST00000247618ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000440884APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000440884APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000247618ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000553942APOPT1chr14

104053701

+MARK3chr14

103969219

+
Frame-shiftENST00000247618ENST00000553942APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000409074ENST00000216288APOPT1chr14

104053701

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000216288APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000216288APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000409074ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103934370

+
Frame-shiftENST00000409074ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000303622APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000303622APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000409074ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000335102APOPT1chr14

104053701

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000335102APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000409074ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103934370

+
Frame-shiftENST00000409074ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000416682APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000416682APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000409074ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103934370

+
Frame-shiftENST00000409074ENST00000429436APOPT1chr14

104053701

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000429436APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000429436APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000409074ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103934370

+
Frame-shiftENST00000409074ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000440884APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000440884APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000409074ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000553942APOPT1chr14

104053701

+MARK3chr14

103969219

+
Frame-shiftENST00000409074ENST00000553942APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000556253ENST00000216288APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000556253ENST00000216288APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000556253ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103934370

+
Frame-shiftENST00000556253ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000556253ENST00000303622APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000556253ENST00000303622APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000556253ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000556253ENST00000335102APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000556253ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103934370

+
Frame-shiftENST00000556253ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000556253ENST00000416682APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000556253ENST00000416682APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000556253ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103934370

+
Frame-shiftENST00000556253ENST00000429436APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000556253ENST00000429436APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000556253ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103934370

+
Frame-shiftENST00000556253ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000556253ENST00000440884APOPT1chr14

104029461

+MARK3chr14

103969219

+
Frame-shiftENST00000556253ENST00000440884APOPT1chr14

104029461

+MARK3chr14

103958114

+
Frame-shiftENST00000556253ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103969219

+
Frame-shiftENST00000556253ENST00000553942APOPT1chr14

104029461

+MARK3chr14

103958114

+
In-frameENST00000247618ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000247618ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103969219

+
In-frameENST00000247618ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000247618ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000247618ENST00000303622APOPT1chr14

104053701

+MARK3chr14

103969219

+
In-frameENST00000247618ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000247618ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000247618ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000247618ENST00000335102APOPT1chr14

104029461

+MARK3chr14

103969219

+
In-frameENST00000247618ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000247618ENST00000416682APOPT1chr14

104053701

+MARK3chr14

103969219

+
In-frameENST00000247618ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000247618ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000247618ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103969219

+
In-frameENST00000247618ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000247618ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000247618ENST00000440884APOPT1chr14

104053701

+MARK3chr14

103969219

+
In-frameENST00000247618ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000247618ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000247618ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000247618ENST00000553942APOPT1chr14

104029461

+MARK3chr14

103969219

+
In-frameENST00000409074ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000409074ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103969219

+
In-frameENST00000409074ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000409074ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000409074ENST00000303622APOPT1chr14

104053701

+MARK3chr14

103969219

+
In-frameENST00000409074ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000409074ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000409074ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000409074ENST00000335102APOPT1chr14

104029461

+MARK3chr14

103969219

+
In-frameENST00000409074ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000409074ENST00000416682APOPT1chr14

104053701

+MARK3chr14

103969219

+
In-frameENST00000409074ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000409074ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000409074ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103969219

+
In-frameENST00000409074ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000409074ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000409074ENST00000440884APOPT1chr14

104053701

+MARK3chr14

103969219

+
In-frameENST00000409074ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000409074ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000409074ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000409074ENST00000553942APOPT1chr14

104029461

+MARK3chr14

103969219

+
In-frameENST00000556253ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000556253ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103969219

+
In-frameENST00000556253ENST00000216288APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000556253ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000556253ENST00000303622APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000556253ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000556253ENST00000335102APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000556253ENST00000335102APOPT1chr14

104029461

+MARK3chr14

103969219

+
In-frameENST00000556253ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000556253ENST00000416682APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000556253ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000556253ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103969219

+
In-frameENST00000556253ENST00000429436APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000556253ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000556253ENST00000440884APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000556253ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103941330

+
In-frameENST00000556253ENST00000553942APOPT1chr14

104040507

+MARK3chr14

103941329

+
In-frameENST00000556253ENST00000553942APOPT1chr14

104029461

+MARK3chr14

103969219

+
intron-3CDSENST00000477116ENST00000216288APOPT1chr14

104029461

+MARK3chr14

103969219

+
intron-3CDSENST00000477116ENST00000216288APOPT1chr14

104029461

+MARK3chr14

103958114

+
intron-3CDSENST00000477116ENST00000303622APOPT1chr14

104029461

+MARK3chr14

103969219

+
intron-3CDSENST00000477116ENST00000303622APOPT1chr14

104029461

+MARK3chr14

103958114

+
intron-3CDSENST00000477116ENST00000335102APOPT1chr14

104029461

+MARK3chr14

103969219

+
intron-3CDSENST00000477116ENST00000335102APOPT1chr14

104029461

+MARK3chr14

103958114

+
intron-3CDSENST00000477116ENST00000416682APOPT1chr14

104029461

+MARK3chr14

103969219

+
intron-3CDSENST00000477116ENST00000416682APOPT1chr14

104029461

+MARK3chr14

103958114

+
intron-3CDSENST00000477116ENST00000429436APOPT1chr14

104029461

+MARK3chr14

103969219

+
intron-3CDSENST00000477116ENST00000429436APOPT1chr14

104029461

+MARK3chr14

103958114

+
intron-3CDSENST00000477116ENST00000440884APOPT1chr14

104029461

+MARK3chr14

103969219

+
intron-3CDSENST00000477116ENST00000440884APOPT1chr14

104029461

+MARK3chr14

103958114

+
intron-3CDSENST00000477116ENST00000553942APOPT1chr14

104029461

+MARK3chr14

103969219

+
intron-3CDSENST00000477116ENST00000553942APOPT1chr14

104029461

+MARK3chr14

103958114

+
intron-3UTRENST00000477116ENST00000561071APOPT1chr14

104029461

+MARK3chr14

103969219

+
intron-3UTRENST00000477116ENST00000561071APOPT1chr14

104029461

+MARK3chr14

103958114

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for APOPT1-MARK3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
APOPT1chr14104053701+MARK3chr14103969218+0.0002690920.9997309
APOPT1chr14104040507+MARK3chr14103969218+0.0001675560.9998324
APOPT1chr14104029461+MARK3chr14103969218+0.0001223650.9998776
APOPT1chr14104029461+MARK3chr14103958113+1.74E-060.9999982
APOPT1chr14104040507+MARK3chr14103941329+7.58E-070.9999993
APOPT1chr14104040507+MARK3chr14103941329+7.58E-070.9999993
APOPT1chr14104040507+MARK3chr14103934369+4.86E-070.9999995
APOPT1chr14104053701+MARK3chr14103969218+0.0002690920.9997309
APOPT1chr14104040507+MARK3chr14103969218+0.0001675560.9998324
APOPT1chr14104029461+MARK3chr14103969218+0.0001223650.9998776
APOPT1chr14104029461+MARK3chr14103958113+1.74E-060.9999982
APOPT1chr14104040507+MARK3chr14103941329+7.58E-070.9999993
APOPT1chr14104040507+MARK3chr14103941329+7.58E-070.9999993
APOPT1chr14104040507+MARK3chr14103934369+4.86E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for APOPT1-MARK3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:104040507/chr14:103941330)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMARK3chr14:104029461chr14:103969219ENST000002162881416704_753598714.0DomainKA1
TgeneMARK3chr14:104029461chr14:103969219ENST000003036221416704_753614730.0DomainKA1
TgeneMARK3chr14:104029461chr14:103969219ENST000004166821517704_753637753.0DomainKA1
TgeneMARK3chr14:104029461chr14:103969219ENST000004294361618704_753638754.0DomainKA1
TgeneMARK3chr14:104029461chr14:103969219ENST000004408841416704_753544660.0DomainKA1
TgeneMARK3chr14:104029461chr14:103969219ENST000005539421517704_753629745.0DomainKA1
TgeneMARK3chr14:104040507chr14:103941329ENST000002162881116704_753405714.0DomainKA1
TgeneMARK3chr14:104040507chr14:103941329ENST000003036221116704_753421730.0DomainKA1
TgeneMARK3chr14:104040507chr14:103941329ENST000004166821217704_753444753.0DomainKA1
TgeneMARK3chr14:104040507chr14:103941329ENST000004294361118704_753421754.0DomainKA1
TgeneMARK3chr14:104040507chr14:103941329ENST000004408841016704_753342660.0DomainKA1
TgeneMARK3chr14:104040507chr14:103941329ENST000005539421117704_753421745.0DomainKA1
TgeneMARK3chr14:104040507chr14:103941330ENST000002162881116704_753405714.0DomainKA1
TgeneMARK3chr14:104040507chr14:103941330ENST000003036221116704_753421730.0DomainKA1
TgeneMARK3chr14:104040507chr14:103941330ENST000004166821217704_753444753.0DomainKA1
TgeneMARK3chr14:104040507chr14:103941330ENST000004294361118704_753421754.0DomainKA1
TgeneMARK3chr14:104040507chr14:103941330ENST000004408841016704_753342660.0DomainKA1
TgeneMARK3chr14:104040507chr14:103941330ENST000005539421117704_753421745.0DomainKA1
TgeneMARK3chr14:104040507chr14:103969219ENST000002162881416704_753598714.0DomainKA1
TgeneMARK3chr14:104040507chr14:103969219ENST000003036221416704_753614730.0DomainKA1
TgeneMARK3chr14:104040507chr14:103969219ENST000004166821517704_753637753.0DomainKA1
TgeneMARK3chr14:104040507chr14:103969219ENST000004294361618704_753638754.0DomainKA1
TgeneMARK3chr14:104040507chr14:103969219ENST000004408841416704_753544660.0DomainKA1
TgeneMARK3chr14:104040507chr14:103969219ENST000005539421517704_753629745.0DomainKA1
TgeneMARK3chr14:104053701chr14:103969219ENST000002162881416704_753598714.0DomainKA1
TgeneMARK3chr14:104053701chr14:103969219ENST000003036221416704_753614730.0DomainKA1
TgeneMARK3chr14:104053701chr14:103969219ENST000004166821517704_753637753.0DomainKA1
TgeneMARK3chr14:104053701chr14:103969219ENST000004294361618704_753638754.0DomainKA1
TgeneMARK3chr14:104053701chr14:103969219ENST000004408841416704_753544660.0DomainKA1
TgeneMARK3chr14:104053701chr14:103969219ENST000005539421517704_753629745.0DomainKA1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMARK3chr14:104029461chr14:103969219ENST000002162881416326_365598714.0DomainUBA
TgeneMARK3chr14:104029461chr14:103969219ENST00000216288141656_307598714.0DomainProtein kinase
TgeneMARK3chr14:104029461chr14:103969219ENST000003036221416326_365614730.0DomainUBA
TgeneMARK3chr14:104029461chr14:103969219ENST00000303622141656_307614730.0DomainProtein kinase
TgeneMARK3chr14:104029461chr14:103969219ENST000004166821517326_365637753.0DomainUBA
TgeneMARK3chr14:104029461chr14:103969219ENST00000416682151756_307637753.0DomainProtein kinase
TgeneMARK3chr14:104029461chr14:103969219ENST000004294361618326_365638754.0DomainUBA
TgeneMARK3chr14:104029461chr14:103969219ENST00000429436161856_307638754.0DomainProtein kinase
TgeneMARK3chr14:104029461chr14:103969219ENST000004408841416326_365544660.0DomainUBA
TgeneMARK3chr14:104029461chr14:103969219ENST00000440884141656_307544660.0DomainProtein kinase
TgeneMARK3chr14:104029461chr14:103969219ENST000005539421517326_365629745.0DomainUBA
TgeneMARK3chr14:104029461chr14:103969219ENST00000553942151756_307629745.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103941329ENST000002162881116326_365405714.0DomainUBA
TgeneMARK3chr14:104040507chr14:103941329ENST00000216288111656_307405714.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103941329ENST000003036221116326_365421730.0DomainUBA
TgeneMARK3chr14:104040507chr14:103941329ENST00000303622111656_307421730.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103941329ENST000004166821217326_365444753.0DomainUBA
TgeneMARK3chr14:104040507chr14:103941329ENST00000416682121756_307444753.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103941329ENST000004294361118326_365421754.0DomainUBA
TgeneMARK3chr14:104040507chr14:103941329ENST00000429436111856_307421754.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103941329ENST000004408841016326_365342660.0DomainUBA
TgeneMARK3chr14:104040507chr14:103941329ENST00000440884101656_307342660.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103941329ENST000005539421117326_365421745.0DomainUBA
TgeneMARK3chr14:104040507chr14:103941329ENST00000553942111756_307421745.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103941330ENST000002162881116326_365405714.0DomainUBA
TgeneMARK3chr14:104040507chr14:103941330ENST00000216288111656_307405714.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103941330ENST000003036221116326_365421730.0DomainUBA
TgeneMARK3chr14:104040507chr14:103941330ENST00000303622111656_307421730.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103941330ENST000004166821217326_365444753.0DomainUBA
TgeneMARK3chr14:104040507chr14:103941330ENST00000416682121756_307444753.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103941330ENST000004294361118326_365421754.0DomainUBA
TgeneMARK3chr14:104040507chr14:103941330ENST00000429436111856_307421754.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103941330ENST000004408841016326_365342660.0DomainUBA
TgeneMARK3chr14:104040507chr14:103941330ENST00000440884101656_307342660.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103941330ENST000005539421117326_365421745.0DomainUBA
TgeneMARK3chr14:104040507chr14:103941330ENST00000553942111756_307421745.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103969219ENST000002162881416326_365598714.0DomainUBA
TgeneMARK3chr14:104040507chr14:103969219ENST00000216288141656_307598714.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103969219ENST000003036221416326_365614730.0DomainUBA
TgeneMARK3chr14:104040507chr14:103969219ENST00000303622141656_307614730.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103969219ENST000004166821517326_365637753.0DomainUBA
TgeneMARK3chr14:104040507chr14:103969219ENST00000416682151756_307637753.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103969219ENST000004294361618326_365638754.0DomainUBA
TgeneMARK3chr14:104040507chr14:103969219ENST00000429436161856_307638754.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103969219ENST000004408841416326_365544660.0DomainUBA
TgeneMARK3chr14:104040507chr14:103969219ENST00000440884141656_307544660.0DomainProtein kinase
TgeneMARK3chr14:104040507chr14:103969219ENST000005539421517326_365629745.0DomainUBA
TgeneMARK3chr14:104040507chr14:103969219ENST00000553942151756_307629745.0DomainProtein kinase
TgeneMARK3chr14:104053701chr14:103969219ENST000002162881416326_365598714.0DomainUBA
TgeneMARK3chr14:104053701chr14:103969219ENST00000216288141656_307598714.0DomainProtein kinase
TgeneMARK3chr14:104053701chr14:103969219ENST000003036221416326_365614730.0DomainUBA
TgeneMARK3chr14:104053701chr14:103969219ENST00000303622141656_307614730.0DomainProtein kinase
TgeneMARK3chr14:104053701chr14:103969219ENST000004166821517326_365637753.0DomainUBA
TgeneMARK3chr14:104053701chr14:103969219ENST00000416682151756_307637753.0DomainProtein kinase
TgeneMARK3chr14:104053701chr14:103969219ENST000004294361618326_365638754.0DomainUBA
TgeneMARK3chr14:104053701chr14:103969219ENST00000429436161856_307638754.0DomainProtein kinase
TgeneMARK3chr14:104053701chr14:103969219ENST000004408841416326_365544660.0DomainUBA
TgeneMARK3chr14:104053701chr14:103969219ENST00000440884141656_307544660.0DomainProtein kinase
TgeneMARK3chr14:104053701chr14:103969219ENST000005539421517326_365629745.0DomainUBA
TgeneMARK3chr14:104053701chr14:103969219ENST00000553942151756_307629745.0DomainProtein kinase
TgeneMARK3chr14:104029461chr14:103969219ENST00000216288141662_70598714.0Nucleotide bindingATP
TgeneMARK3chr14:104029461chr14:103969219ENST00000303622141662_70614730.0Nucleotide bindingATP
TgeneMARK3chr14:104029461chr14:103969219ENST00000416682151762_70637753.0Nucleotide bindingATP
TgeneMARK3chr14:104029461chr14:103969219ENST00000429436161862_70638754.0Nucleotide bindingATP
TgeneMARK3chr14:104029461chr14:103969219ENST00000440884141662_70544660.0Nucleotide bindingATP
TgeneMARK3chr14:104029461chr14:103969219ENST00000553942151762_70629745.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103941329ENST00000216288111662_70405714.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103941329ENST00000303622111662_70421730.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103941329ENST00000416682121762_70444753.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103941329ENST00000429436111862_70421754.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103941329ENST00000440884101662_70342660.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103941329ENST00000553942111762_70421745.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103941330ENST00000216288111662_70405714.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103941330ENST00000303622111662_70421730.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103941330ENST00000416682121762_70444753.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103941330ENST00000429436111862_70421754.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103941330ENST00000440884101662_70342660.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103941330ENST00000553942111762_70421745.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103969219ENST00000216288141662_70598714.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103969219ENST00000303622141662_70614730.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103969219ENST00000416682151762_70637753.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103969219ENST00000429436161862_70638754.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103969219ENST00000440884141662_70544660.0Nucleotide bindingATP
TgeneMARK3chr14:104040507chr14:103969219ENST00000553942151762_70629745.0Nucleotide bindingATP
TgeneMARK3chr14:104053701chr14:103969219ENST00000216288141662_70598714.0Nucleotide bindingATP
TgeneMARK3chr14:104053701chr14:103969219ENST00000303622141662_70614730.0Nucleotide bindingATP
TgeneMARK3chr14:104053701chr14:103969219ENST00000416682151762_70637753.0Nucleotide bindingATP
TgeneMARK3chr14:104053701chr14:103969219ENST00000429436161862_70638754.0Nucleotide bindingATP
TgeneMARK3chr14:104053701chr14:103969219ENST00000440884141662_70544660.0Nucleotide bindingATP
TgeneMARK3chr14:104053701chr14:103969219ENST00000553942151762_70629745.0Nucleotide bindingATP


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Fusion Gene Sequence for APOPT1-MARK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for APOPT1-MARK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APOPT1-MARK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APOPT1-MARK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4748978VISUAL IMPAIRMENT AND PROGRESSIVE PHTHISIS BULBI1UNIPROT