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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CASP10-CFLAR (FusionGDB2 ID:HG843TG8837)

Fusion Gene Summary for CASP10-CFLAR

Fusion gene summary

Fusion gene information	Fusion gene name: CASP10-CFLAR
	Fusion gene ID: hg843tg8837
		Hgene	Tgene
	Gene symbol	CASP10	CFLAR
	Gene ID	843	8837
	Gene name	caspase 10	CASP8 and FADD like apoptosis regulator
	Synonyms	ALPS2\|FLICE2\|MCH4	CASH\|CASP8AP1\|CLARP\|Casper\|FLAME\|FLAME-1\|FLAME1\|FLIP\|I-FLICE\|MRIT\|c-FLIP\|c-FLIPL\|c-FLIPR\|c-FLIPS\|cFLIP
	Cytomap	('CASP10')('CFLAR') 2q33.1	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	caspase-10CASP-10FADD-like ICE2FAS-associated death domain protein interleukin-1B-converting enzyme 2ICE-like apoptotic protease 4apoptotic protease MCH-4caspase 10 apoptosis-related cysteine peptidasecaspase 10, apoptosis-related cysteine protease	CASP8 and FADD-like apoptosis regulatorFADD-like antiapoptotic molecule 1MACH-related inducer of toxicitycaspase homologcaspase-eight-related proteincaspase-like apoptosis regulatory proteincaspase-related inducer of apoptosiscellular FLICE-like in
	Modification date	20200313	20200322
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000492363, ENST00000272879, ENST00000286186, ENST00000313728, ENST00000346817, ENST00000360132, ENST00000374650, ENST00000448480,
Fusion gene scores	* DoF score	4 X 5 X 3=60	10 X 11 X 6=660
	# samples	6	14
	** MAII score	log2(6/60*10)=0	log2(14/660*10)=-2.23703919730085 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CASP10 [Title/Abstract] AND CFLAR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CASP10(202052522)-CFLAR(202010100), # samples:1 CASP10(202052522)-CFLAR(202010101), # samples:1 CASP10(202070696)-CFLAR(201994452), # samples:1
Anticipated loss of major functional domain due to fusion event.	CASP10-CFLAR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CASP10-CFLAR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CASP10-CFLAR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CASP10-CFLAR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CFLAR	GO:0060544	regulation of necroptotic process	21737330
Tgene	CFLAR	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	26582200
Tgene	CFLAR	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	9208847

Fusion gene breakpoints across CASP10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CFLAR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-71-8520-01A	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
ChimerDB4	STAD	TCGA-VQ-A91K-01A	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
ChimerDB4	STAD	TCGA-VQ-A91K	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+

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Fusion Gene ORF analysis for CASP10-CFLAR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000492363	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-3CDS	ENST00000492363	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
3UTR-3CDS	ENST00000492363	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-3CDS	ENST00000492363	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
3UTR-intron	ENST00000492363	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-intron	ENST00000492363	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
3UTR-intron	ENST00000492363	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-intron	ENST00000492363	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
3UTR-intron	ENST00000492363	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-intron	ENST00000492363	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
3UTR-intron	ENST00000492363	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-intron	ENST00000492363	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
3UTR-intron	ENST00000492363	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-intron	ENST00000492363	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
3UTR-intron	ENST00000492363	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-intron	ENST00000492363	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
3UTR-intron	ENST00000492363	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-intron	ENST00000492363	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
3UTR-intron	ENST00000492363	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-intron	ENST00000492363	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
3UTR-intron	ENST00000492363	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-intron	ENST00000492363	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
3UTR-intron	ENST00000492363	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-intron	ENST00000492363	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
3UTR-intron	ENST00000492363	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-intron	ENST00000492363	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
3UTR-intron	ENST00000492363	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
3UTR-intron	ENST00000492363	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-5UTR	ENST00000272879	ENST00000309955	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000272879	ENST00000340870	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000272879	ENST00000341222	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000272879	ENST00000341582	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000272879	ENST00000342795	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000272879	ENST00000355558	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000272879	ENST00000395148	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000272879	ENST00000423241	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000272879	ENST00000440180	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000286186	ENST00000309955	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000286186	ENST00000340870	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000286186	ENST00000341222	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000286186	ENST00000341582	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000286186	ENST00000342795	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000286186	ENST00000355558	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000286186	ENST00000395148	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000286186	ENST00000423241	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000286186	ENST00000440180	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000272879	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000272879	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000272879	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000272879	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000272879	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000272879	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000272879	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000272879	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000272879	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000272879	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000272879	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000272879	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000272879	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000272879	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000272879	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000272879	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000272879	ENST00000443227	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000272879	ENST00000457277	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000272879	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000272879	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000272879	ENST00000479953	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000272879	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000272879	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000272879	ENST00000490965	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000272879	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000272879	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000272879	ENST00000494258	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000272879	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000272879	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000286186	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000286186	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000286186	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000286186	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000286186	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000286186	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000286186	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000286186	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000286186	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000286186	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000286186	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000286186	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000286186	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000286186	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000286186	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000286186	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000286186	ENST00000443227	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000286186	ENST00000457277	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000286186	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000286186	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000286186	ENST00000479953	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000286186	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000286186	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000286186	ENST00000490965	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000286186	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000286186	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000286186	ENST00000494258	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000286186	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000286186	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000313728	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000313728	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000313728	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000313728	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000313728	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000313728	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000313728	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000313728	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000313728	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000313728	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000313728	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000313728	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000313728	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000313728	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000313728	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000313728	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000313728	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000313728	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000313728	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000313728	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000313728	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000313728	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000313728	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000313728	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000346817	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000346817	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000346817	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000346817	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000346817	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000346817	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000346817	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000346817	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000346817	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000346817	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000346817	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000346817	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000346817	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000346817	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000346817	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000346817	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000346817	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000346817	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000346817	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000346817	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000346817	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000346817	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000346817	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000346817	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000360132	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000360132	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000360132	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000360132	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000360132	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000360132	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000360132	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000360132	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000360132	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000360132	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000360132	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000360132	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000360132	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000360132	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000360132	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000360132	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000360132	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000360132	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000360132	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000360132	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000360132	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000360132	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000360132	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000360132	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000374650	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000374650	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000374650	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000374650	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000374650	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000374650	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000374650	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000374650	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000374650	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000374650	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000374650	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000374650	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000374650	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000374650	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000374650	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000374650	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000374650	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000374650	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000374650	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000374650	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000374650	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000374650	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000374650	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000374650	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000448480	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000448480	ENST00000340870	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000448480	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000448480	ENST00000341222	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000448480	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000448480	ENST00000341582	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000448480	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000448480	ENST00000342795	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000448480	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000448480	ENST00000355558	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000448480	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000448480	ENST00000395148	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000448480	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000448480	ENST00000423241	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000448480	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000448480	ENST00000440180	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000448480	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000448480	ENST00000457277	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000448480	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000448480	ENST00000479953	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000448480	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000448480	ENST00000490965	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
5CDS-intron	ENST00000448480	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
5CDS-intron	ENST00000448480	ENST00000494258	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000272879	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000272879	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000272879	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000272879	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000286186	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000286186	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000286186	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000286186	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000313728	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000313728	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000313728	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000313728	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000346817	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000346817	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000346817	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000346817	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000360132	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000360132	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000360132	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000360132	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000374650	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000374650	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000374650	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000374650	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000448480	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000448480	ENST00000309955	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
In-frame	ENST00000448480	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010101	+
In-frame	ENST00000448480	ENST00000443227	CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+
intron-5UTR	ENST00000313728	ENST00000309955	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000313728	ENST00000340870	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000313728	ENST00000341222	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000313728	ENST00000341582	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000313728	ENST00000342795	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000313728	ENST00000355558	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000313728	ENST00000395148	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000313728	ENST00000423241	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000313728	ENST00000440180	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000346817	ENST00000309955	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000346817	ENST00000340870	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000346817	ENST00000341222	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000346817	ENST00000341582	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000346817	ENST00000342795	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000346817	ENST00000355558	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000346817	ENST00000395148	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000346817	ENST00000423241	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000346817	ENST00000440180	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000360132	ENST00000309955	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000360132	ENST00000340870	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000360132	ENST00000341222	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000360132	ENST00000341582	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000360132	ENST00000342795	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000360132	ENST00000355558	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000360132	ENST00000395148	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000360132	ENST00000423241	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000360132	ENST00000440180	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000374650	ENST00000309955	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000374650	ENST00000340870	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000374650	ENST00000341222	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000374650	ENST00000341582	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000374650	ENST00000342795	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000374650	ENST00000355558	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000374650	ENST00000395148	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000374650	ENST00000423241	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000374650	ENST00000440180	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000448480	ENST00000309955	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000448480	ENST00000340870	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000448480	ENST00000341222	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000448480	ENST00000341582	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000448480	ENST00000342795	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000448480	ENST00000355558	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000448480	ENST00000395148	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000448480	ENST00000423241	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000448480	ENST00000440180	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000492363	ENST00000309955	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000492363	ENST00000340870	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000492363	ENST00000341222	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000492363	ENST00000341582	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000492363	ENST00000342795	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000492363	ENST00000355558	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000492363	ENST00000395148	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000492363	ENST00000423241	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000492363	ENST00000440180	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000313728	ENST00000443227	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000313728	ENST00000457277	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000313728	ENST00000479953	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000313728	ENST00000490965	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000313728	ENST00000494258	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000346817	ENST00000443227	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000346817	ENST00000457277	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000346817	ENST00000479953	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000346817	ENST00000490965	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000346817	ENST00000494258	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000360132	ENST00000443227	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000360132	ENST00000457277	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000360132	ENST00000479953	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000360132	ENST00000490965	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000360132	ENST00000494258	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000374650	ENST00000443227	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000374650	ENST00000457277	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000374650	ENST00000479953	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000374650	ENST00000490965	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000374650	ENST00000494258	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000448480	ENST00000443227	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000448480	ENST00000457277	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000448480	ENST00000479953	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000448480	ENST00000490965	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000448480	ENST00000494258	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000492363	ENST00000443227	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000492363	ENST00000457277	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000492363	ENST00000479953	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000492363	ENST00000490965	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000492363	ENST00000494258	CASP10	chr2	202070696	-	CFLAR	chr2	201994452	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for CASP10-CFLAR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+	4.47E-06	0.99999547
CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+	4.47E-06	0.99999547
CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+	4.47E-06	0.99999547
CASP10	chr2	202052522	+	CFLAR	chr2	202010100	+	4.47E-06	0.99999547

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CASP10-CFLAR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:202052522/chr2:202010100)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000272879

19_97

147

522.0

Domain

DED 1

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000286186

19_97

147

523.0

Domain

DED 1

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000313728

19_97

147

456.0

Domain

DED 1

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000346817

19_97

147

480.0

Domain

DED 1

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000360132

19_97

147

1541.0

Domain

DED 1

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000374650

19_97

147

248.0

Domain

DED 1

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000448480

19_97

147

479.0

Domain

DED 1

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000272879

19_97

147

522.0

Domain

DED 1

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000286186

19_97

147

523.0

Domain

DED 1

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000313728

19_97

147

456.0

Domain

DED 1

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000346817

19_97

147

480.0

Domain

DED 1

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000360132

19_97

147

1541.0

Domain

DED 1

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000374650

19_97

147

248.0

Domain

DED 1

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000448480

19_97

147

479.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000341222

1_73

222.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000341222

92_170

222.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000341582

1_73

446.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000341582

92_170

446.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000440180

1_73

222.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000440180

92_170

222.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000341222

1_73

222.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000341222

92_170

222.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000341582

1_73

446.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000341582

92_170

446.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000440180

1_73

222.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000440180

92_170

222.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000309955

263_358

202

481.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000340870

263_358

202

463.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000341222

1_435

222.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000341222

263_358

222.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000341582

1_435

446.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000341582

263_358

446.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000342795

263_358

202

293.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000423241

263_358

202

481.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000440180

1_435

222.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000440180

263_358

222.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000443227

263_358

106

385.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000457277

263_358

202

463.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000479953

263_358

106

367.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000309955

263_358

202

481.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000340870

263_358

202

463.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000341222

1_435

222.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000341222

263_358

222.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000341582

1_435

446.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000341582

263_358

446.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000342795

263_358

202

293.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000423241

263_358

202

481.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000440180

1_435

222.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000440180

263_358

222.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000443227

263_358

106

385.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000457277

263_358

202

463.0

Region

Note=Caspase

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000479953

263_358

106

367.0

Region

Note=Caspase

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000272879

114_187

147

522.0

Domain

DED 2

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000286186

114_187

147

523.0

Domain

DED 2

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000313728

114_187

147

456.0

Domain

DED 2

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000346817

114_187

147

480.0

Domain

DED 2

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000360132

114_187

147

1541.0

Domain

DED 2

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000374650

114_187

147

248.0

Domain

DED 2

Hgene

CASP10

chr2:202052522

chr2:202010100

ENST00000448480

114_187

147

479.0

Domain

DED 2

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000272879

114_187

147

522.0

Domain

DED 2

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000286186

114_187

147

523.0

Domain

DED 2

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000313728

114_187

147

456.0

Domain

DED 2

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000346817

114_187

147

480.0

Domain

DED 2

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000360132

114_187

147

1541.0

Domain

DED 2

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000374650

114_187

147

248.0

Domain

DED 2

Hgene

CASP10

chr2:202052522

chr2:202010101

ENST00000448480

114_187

147

479.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000309955

1_73

202

481.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000309955

92_170

202

481.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000340870

1_73

202

463.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000340870

92_170

202

463.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000342795

1_73

202

293.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000342795

92_170

202

293.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000423241

1_73

202

481.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000423241

92_170

202

481.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000443227

1_73

106

385.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000443227

92_170

106

385.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000457277

1_73

202

463.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000457277

92_170

202

463.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000479953

1_73

106

367.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000479953

92_170

106

367.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000309955

1_73

202

481.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000309955

92_170

202

481.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000340870

1_73

202

463.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000340870

92_170

202

463.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000342795

1_73

202

293.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000342795

92_170

202

293.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000423241

1_73

202

481.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000423241

92_170

202

481.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000443227

1_73

106

385.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000443227

92_170

106

385.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000457277

1_73

202

463.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000457277

92_170

202

463.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000479953

1_73

106

367.0

Domain

DED 1

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000479953

92_170

106

367.0

Domain

DED 2

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000309955

1_435

202

481.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000340870

1_435

202

463.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000342795

1_435

202

293.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000423241

1_435

202

481.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000443227

1_435

106

385.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000457277

1_435

202

463.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010100

ENST00000479953

1_435

106

367.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000309955

1_435

202

481.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000340870

1_435

202

463.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000342795

1_435

202

293.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000423241

1_435

202

481.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000443227

1_435

106

385.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000457277

1_435

202

463.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Tgene

CFLAR

chr2:202052522

chr2:202010101

ENST00000479953

1_435

106

367.0

Region

Note=Not proteolytically processed and involved in apoptosis inhibition

Top

Fusion Gene Sequence for CASP10-CFLAR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CASP10-CFLAR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341222		0	6	192_435	0	222.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341582		0	8	192_435	0	446.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000440180		0	5	192_435	0	222.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000443227		3	9	192_435	106.0	385.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000479953		2	8	192_435	106.0	367.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341222		0	6	192_435	0	222.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341582		0	8	192_435	0	446.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000440180		0	5	192_435	0	222.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000443227		3	9	192_435	106.0	385.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000479953		2	8	192_435	106.0	367.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341222		0	6	1_305	0	222.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341582		0	8	1_305	0	446.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000440180		0	5	1_305	0	222.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341222		0	6	1_305	0	222.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341582		0	8	1_305	0	446.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000440180		0	5	1_305	0	222.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000309955		4	10	217_480	202.0	481.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000340870		4	10	217_480	202.0	463.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341222		0	6	217_480	0	222.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341582		0	8	217_480	0	446.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000342795		4	9	217_480	202.0	293.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000423241		4	10	217_480	202.0	481.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000440180		0	5	217_480	0	222.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000443227		3	9	217_480	106.0	385.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000457277		3	9	217_480	202.0	463.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000479953		2	8	217_480	106.0	367.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000309955		4	10	217_480	202.0	481.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000340870		4	10	217_480	202.0	463.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341222		0	6	217_480	0	222.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341582		0	8	217_480	0	446.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000342795		4	9	217_480	202.0	293.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000423241		4	10	217_480	202.0	481.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000440180		0	5	217_480	0	222.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000443227		3	9	217_480	106.0	385.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000457277		3	9	217_480	202.0	463.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000479953		2	8	217_480	106.0	367.0	CASP8 subunits p18 and p10
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000309955		4	10	370_480	202.0	481.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000340870		4	10	370_480	202.0	463.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341222		0	6	1_195	0	222.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341222		0	6	370_480	0	222.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341582		0	8	1_195	0	446.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341582		0	8	370_480	0	446.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000342795		4	9	370_480	202.0	293.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000423241		4	10	370_480	202.0	481.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000440180		0	5	1_195	0	222.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000440180		0	5	370_480	0	222.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000443227		3	9	370_480	106.0	385.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000457277		3	9	370_480	202.0	463.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000479953		2	8	370_480	106.0	367.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000309955		4	10	370_480	202.0	481.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000340870		4	10	370_480	202.0	463.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341222		0	6	1_195	0	222.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341222		0	6	370_480	0	222.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341582		0	8	1_195	0	446.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341582		0	8	370_480	0	446.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000342795		4	9	370_480	202.0	293.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000423241		4	10	370_480	202.0	481.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000440180		0	5	1_195	0	222.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000440180		0	5	370_480	0	222.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000443227		3	9	370_480	106.0	385.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000457277		3	9	370_480	202.0	463.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000479953		2	8	370_480	106.0	367.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341222		0	6	1_227	0	222.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341582		0	8	1_227	0	446.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000440180		0	5	1_227	0	222.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341222		0	6	1_227	0	222.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341582		0	8	1_227	0	446.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000440180		0	5	1_227	0	222.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341222		0	6	192_480	0	222.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000341582		0	8	192_480	0	446.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000440180		0	5	192_480	0	222.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000443227		3	9	192_480	106.0	385.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000479953		2	8	192_480	106.0	367.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341222		0	6	192_480	0	222.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000341582		0	8	192_480	0	446.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000440180		0	5	192_480	0	222.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000443227		3	9	192_480	106.0	385.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000479953		2	8	192_480	106.0	367.0	TRAF1 and TRAF2

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000309955		4	10	192_435	202.0	481.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000340870		4	10	192_435	202.0	463.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000342795		4	9	192_435	202.0	293.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000423241		4	10	192_435	202.0	481.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000457277		3	9	192_435	202.0	463.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000309955		4	10	192_435	202.0	481.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000340870		4	10	192_435	202.0	463.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000342795		4	9	192_435	202.0	293.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000423241		4	10	192_435	202.0	481.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000457277		3	9	192_435	202.0	463.0	CASP3
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000309955		4	10	1_305	202.0	481.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000340870		4	10	1_305	202.0	463.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000342795		4	9	1_305	202.0	293.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000423241		4	10	1_305	202.0	481.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000443227		3	9	1_305	106.0	385.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000457277		3	9	1_305	202.0	463.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000479953		2	8	1_305	106.0	367.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000309955		4	10	1_305	202.0	481.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000340870		4	10	1_305	202.0	463.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000342795		4	9	1_305	202.0	293.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000423241		4	10	1_305	202.0	481.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000443227		3	9	1_305	106.0	385.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000457277		3	9	1_305	202.0	463.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000479953		2	8	1_305	106.0	367.0	CASP8 propeptide
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000309955		4	10	1_195	202.0	481.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000340870		4	10	1_195	202.0	463.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000342795		4	9	1_195	202.0	293.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000423241		4	10	1_195	202.0	481.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000443227		3	9	1_195	106.0	385.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000457277		3	9	1_195	202.0	463.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000479953		2	8	1_195	106.0	367.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000309955		4	10	1_195	202.0	481.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000340870		4	10	1_195	202.0	463.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000342795		4	9	1_195	202.0	293.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000423241		4	10	1_195	202.0	481.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000443227		3	9	1_195	106.0	385.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000457277		3	9	1_195	202.0	463.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000479953		2	8	1_195	106.0	367.0	CASP8
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000309955		4	10	1_227	202.0	481.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000340870		4	10	1_227	202.0	463.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000342795		4	9	1_227	202.0	293.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000423241		4	10	1_227	202.0	481.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000443227		3	9	1_227	106.0	385.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000457277		3	9	1_227	202.0	463.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000479953		2	8	1_227	106.0	367.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000309955		4	10	1_227	202.0	481.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000340870		4	10	1_227	202.0	463.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000342795		4	9	1_227	202.0	293.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000423241		4	10	1_227	202.0	481.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000443227		3	9	1_227	106.0	385.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000457277		3	9	1_227	202.0	463.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000479953		2	8	1_227	106.0	367.0	FADD
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000309955		4	10	192_480	202.0	481.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000340870		4	10	192_480	202.0	463.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000342795		4	9	192_480	202.0	293.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000423241		4	10	192_480	202.0	481.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010100	ENST00000457277		3	9	192_480	202.0	463.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000309955		4	10	192_480	202.0	481.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000340870		4	10	192_480	202.0	463.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000342795		4	9	192_480	202.0	293.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000423241		4	10	192_480	202.0	481.0	TRAF1 and TRAF2
Tgene	CFLAR	chr2:202052522	chr2:202010101	ENST00000457277		3	9	192_480	202.0	463.0	TRAF1 and TRAF2

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CASP10-CFLAR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CASP10-CFLAR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CASP10	C1328840	Autoimmune Lymphoproliferative Syndrome	2	ORPHANET
Hgene	CASP10	C1858968	Autoimmune Lymphoproliferative Syndrome, Type IIA	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	CASP10	C0007114	Malignant neoplasm of skin	1	CTD_human
Hgene	CASP10	C0025202	melanoma	1	CTD_human
Hgene	CASP10	C0037286	Skin Neoplasms	1	CTD_human
Hgene	CASP10	C0699791	Stomach Carcinoma	1	CGI;UNIPROT
Hgene	CASP10	C4721532	Lymphoma, Non-Hodgkin, Familial	1	CTD_human;UNIPROT
Tgene		C0019829	Hodgkin Disease	1	CTD_human
Tgene		C0023418	leukemia	1	CTD_human
Tgene		C0030297	Pancreatic Neoplasm	1	CTD_human
Tgene		C0152266	Mixed Cellularity Hodgkin Lymphoma	1	CTD_human
Tgene		C0152267	Hodgkin lymphoma, lymphocyte depletion	1	CTD_human
Tgene		C0220597	Adult Hodgkin Lymphoma	1	CTD_human
Tgene		C0346647	Malignant neoplasm of pancreas	1	CTD_human
Tgene		C0392788	Nasal Type Extranodal NK/T-Cell Lymphoma	1	CTD_human
Tgene		C1266194	Lymphocyte Rich Classical Hodgkin Lymphoma	1	CTD_human
Tgene		C1334968	Nodular Lymphocyte Predominant Hodgkin Lymphoma	1	CTD_human
Tgene		C1955906	Lymphoma, Extranodal NK-T-Cell	1	CTD_human
Tgene		C2713368	Hematopoetic Myelodysplasia	1	CTD_human
Tgene		C3463824	MYELODYSPLASTIC SYNDROME	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:CASP10-CFLAR (FusionGDB2 ID:HG843TG8837)

Fusion Gene Summary for CASP10-CFLAR

Fusion Gene ORF analysis for CASP10-CFLAR

Fusion Genomic Features for CASP10-CFLAR

Fusion Protein Features for CASP10-CFLAR

Fusion Gene Sequence for CASP10-CFLAR

Fusion Gene PPI Analysis for CASP10-CFLAR

Related Drugs for CASP10-CFLAR

Related Diseases for CASP10-CFLAR

Fusion Gene Studies
in Kim Lab