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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CARD11-ZNRD1 (FusionGDB2 ID:HG84433TG30834)

Fusion Gene Summary for CARD11-ZNRD1

check button Fusion gene summary
Fusion gene informationFusion gene name: CARD11-ZNRD1
Fusion gene ID: hg84433tg30834
HgeneTgene
Gene symbol

CARD11

ZNRD1

Gene ID

84433

30834

Gene namecaspase recruitment domain family member 11zinc ribbon domain containing 1
SynonymsBENTA|BIMP3|CARMA1|IMD11|IMD11A|PPBLA12.2|HTEX-6|HTEX6|Rpa12|TCTEX6|TEX6|ZR14|hZR14|tctex-6
Cytomap('CARD11')('ZNRD1')

7p22.2

6p22.1

Type of geneprotein-codingprotein-coding
Descriptioncaspase recruitment domain-containing protein 11CARD-containing MAGUK protein 1bcl10-interacting maguk protein 3carma 1DNA-directed RNA polymerase I subunit RPA12RNA polymerase I small specific subunit Rpa12transcription-associated zinc ribbon protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000396946, 
Fusion gene scores* DoF score6 X 5 X 5=1503 X 3 X 2=18
# samples 63
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CARD11 [Title/Abstract] AND ZNRD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCARD11(3083301)-ZNRD1(30029292), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCARD11

GO:0031295

T cell costimulation

17287217



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-DM-A28F-01ACARD11chr7

3083301

-ZNRD1chr6

30029292

+


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Fusion Gene ORF analysis for CARD11-ZNRD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000396946ENST00000463141CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-5UTRENST00000396946ENST00000332435CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-5UTRENST00000396946ENST00000359374CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-5UTRENST00000396946ENST00000376782CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-5UTRENST00000396946ENST00000376785CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000383613CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000400659CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000400660CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000400662CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000412396CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000417275CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000417738CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000420100CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000428913CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000429558CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000431032CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000431416CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000432227CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000432545CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000432904CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000433264CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000437373CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000437507CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000441251CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000442585CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000443142CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000443494CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000444027CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000444794CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000446493CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000451875CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000453694CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000455948CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000459984CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000471263CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000472459CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000476397CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000476699CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000477956CARD11chr7

3083301

-ZNRD1chr6

30029292

+
5UTR-intronENST00000396946ENST00000484119CARD11chr7

3083301

-ZNRD1chr6

30029292

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CARD11-ZNRD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CARD11chr73083300-ZNRD1chr630029291+0.972324970.027675023
CARD11chr73083300-ZNRD1chr630029291+0.972324970.027675023


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CARD11-ZNRD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:3083301/:30029292)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CARD11-ZNRD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CARD11-ZNRD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CARD11-ZNRD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CARD11-ZNRD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCARD11C4551967B-CELL EXPANSION WITH NFKB AND T-CELL ANERGY5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneCARD11C3554686IMMUNODEFICIENCY 113CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneCARD11C0011615Dermatitis, Atopic2CTD_human
HgeneCARD11C0036920Sezary Syndrome2CTD_human
HgeneCARD11C0079744Diffuse Large B-Cell Lymphoma2CGI;CTD_human
HgeneCARD11C0086196Eczema, Infantile2CTD_human
HgeneCARD11C4539957IMMUNODEFICIENCY 11B WITH ATOPIC DERMATITIS2GENOMICS_ENGLAND;UNIPROT
HgeneCARD11C0007134Renal Cell Carcinoma1CTD_human
HgeneCARD11C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
HgeneCARD11C0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneCARD11C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneCARD11C0376407Granulomatous Slack Skin1CTD_human
HgeneCARD11C0494261Combined immunodeficiency1GENOMICS_ENGLAND
HgeneCARD11C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneCARD11C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneCARD11C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneCARD11C1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0027659Neoplasms, Experimental1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human