Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DYRK2-SEC31A (FusionGDB2 ID:HG8445TG22872)

Fusion Gene Summary for DYRK2-SEC31A

check button Fusion gene summary
Fusion gene informationFusion gene name: DYRK2-SEC31A
Fusion gene ID: hg8445tg22872
HgeneTgene
Gene symbol

DYRK2

SEC31A

Gene ID

8445

22872

Gene namedual specificity tyrosine phosphorylation regulated kinase 2SEC31 homolog A, COPII coat complex component
Synonyms-ABP125|ABP130|HSPC275|HSPC334|NEDSOSB|SEC31L1
Cytomap('DYRK2')('SEC31A')

12q15

4q21.22

Type of geneprotein-codingprotein-coding
Descriptiondual specificity tyrosine-phosphorylation-regulated kinase 2dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2protein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homolog
Modification date2020031320200313
UniProtAcc

Q92630

O94979

Ensembl transtripts involved in fusion geneENST00000537632, ENST00000344096, 
ENST00000393555, 
Fusion gene scores* DoF score6 X 6 X 3=10827 X 19 X 11=5643
# samples 728
** MAII scorelog2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/5643*10)=-4.33296361729939
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DYRK2 [Title/Abstract] AND SEC31A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDYRK2(68043725)-SEC31A(83750211), # samples:2
Anticipated loss of major functional domain due to fusion event.DYRK2-SEC31A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DYRK2-SEC31A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
DYRK2-SEC31A seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
DYRK2-SEC31A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDYRK2

GO:0006468

protein phosphorylation

11311121

HgeneDYRK2

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

17349958

HgeneDYRK2

GO:0045725

positive regulation of glycogen biosynthetic process

11311121

TgeneSEC31A

GO:0051592

response to calcium ion

17196169

TgeneSEC31A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A4MIDYRK2chr12

68043725

+SEC31Achr4

83750211

-
ChimerDB4UCECTCGA-B5-A11NDYRK2chr12

68043725

+SEC31Achr4

83750211

-


Top

Fusion Gene ORF analysis for DYRK2-SEC31A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000537632ENST00000264405DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000311785DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000326950DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000348405DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000355196DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000395310DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000432794DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000443462DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000448323DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000500777DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000505472DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000505984DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000508502DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000509142DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-3CDSENST00000537632ENST00000513858DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-intronENST00000537632ENST00000436790DYRK2chr12

68043725

+SEC31Achr4

83750211

-
3UTR-intronENST00000537632ENST00000508479DYRK2chr12

68043725

+SEC31Achr4

83750211

-
5CDS-intronENST00000344096ENST00000436790DYRK2chr12

68043725

+SEC31Achr4

83750211

-
5CDS-intronENST00000344096ENST00000508479DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000264405DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000311785DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000326950DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000348405DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000355196DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000395310DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000432794DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000443462DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000448323DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000500777DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000505472DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000505984DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000508502DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000509142DYRK2chr12

68043725

+SEC31Achr4

83750211

-
Frame-shiftENST00000344096ENST00000513858DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000264405DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000311785DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000326950DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000348405DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000355196DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000395310DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000432794DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000443462DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000448323DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000500777DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000505472DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000505984DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000508502DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000509142DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-3CDSENST00000393555ENST00000513858DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-intronENST00000393555ENST00000436790DYRK2chr12

68043725

+SEC31Achr4

83750211

-
intron-intronENST00000393555ENST00000508479DYRK2chr12

68043725

+SEC31Achr4

83750211

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for DYRK2-SEC31A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for DYRK2-SEC31A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:68043725/:83750211)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYRK2

Q92630

SEC31A

O94979

FUNCTION: Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}.FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for DYRK2-SEC31A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for DYRK2-SEC31A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DYRK2-SEC31A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DYRK2-SEC31A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDYRK2C0238198Gastrointestinal Stromal Tumors1CTD_human
HgeneDYRK2C3179349Gastrointestinal Stromal Sarcoma1CTD_human
TgeneC0079744Diffuse Large B-Cell Lymphoma1CTD_human