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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:DHX16-HLA-E (FusionGDB2 ID:HG8449TG3133)

Fusion Gene Summary for DHX16-HLA-E

check button Fusion gene summary
Fusion gene informationFusion gene name: DHX16-HLA-E
Fusion gene ID: hg8449tg3133
HgeneTgene
Gene symbol

DHX16

HLA-E

Gene ID

8449

3133

Gene nameDEAH-box helicase 16major histocompatibility complex, class I, E
SynonymsDBP2|DDX16|NMOAS|PRO2014|PRP8|PRPF2|Prp2HLA-6.2|QA1
Cytomap('DHX16')('HLA-E')

6p21.33

6p22.1

Type of geneprotein-codingprotein-coding
Descriptionpre-mRNA-splicing factor ATP-dependent RNA helicase DHX16ATP-dependent RNA helicase #3DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16DEAD/H box 16DEAH (Asp-Glu-Ala-His) box polypeptide 16DEAH-box protein 16RNA helicaseputative pre-mRNA-splicing facHLA class I histocompatibility antigen, alpha chain EMHC class I antigen EMHC class Ib antigen
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000376442, ENST00000376437, 
ENST00000383576, ENST00000383577, 
ENST00000414052, ENST00000417308, 
ENST00000421095, ENST00000424672, 
ENST00000445379, ENST00000449861, 
ENST00000451456, ENST00000451748, 
ENST00000453879, ENST00000458094, 
ENST00000461170, ENST00000462469, 
ENST00000477800, ENST00000480637, 
ENST00000480966, ENST00000481393, 
ENST00000485518, ENST00000492529, 
ENST00000548461, 
Fusion gene scores* DoF score3 X 4 X 4=483 X 3 X 2=18
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DHX16 [Title/Abstract] AND HLA-E [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDHX16(30638187)-HLA-E(30460181), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDHX16

GO:0000398

mRNA splicing, via spliceosome

29360106

TgeneHLA-E

GO:0001815

positive regulation of antibody-dependent cellular cytotoxicity

30134159

TgeneHLA-E

GO:0001916

positive regulation of T cell mediated cytotoxicity

25631937

TgeneHLA-E

GO:0002250

adaptive immune response

25631937

TgeneHLA-E

GO:0002476

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

9754572

TgeneHLA-E

GO:0002477

antigen processing and presentation of exogenous peptide antigen via MHC class Ib

30087334

TgeneHLA-E

GO:0002519

natural killer cell tolerance induction

9486650

TgeneHLA-E

GO:0002715

regulation of natural killer cell mediated immunity

18448674

TgeneHLA-E

GO:0002717

positive regulation of natural killer cell mediated immunity

9754572

TgeneHLA-E

GO:0002729

positive regulation of natural killer cell cytokine production

30134159

TgeneHLA-E

GO:0019731

antibacterial humoral response

25631937

TgeneHLA-E

GO:0032736

positive regulation of interleukin-13 production

25631937

TgeneHLA-E

GO:0032753

positive regulation of interleukin-4 production

25631937

TgeneHLA-E

GO:0032759

positive regulation of TRAIL production

25631937

TgeneHLA-E

GO:0032760

positive regulation of tumor necrosis factor production

25631937

TgeneHLA-E

GO:0032819

positive regulation of natural killer cell proliferation

30134159

TgeneHLA-E

GO:0036037

CD8-positive, alpha-beta T cell activation

25631937

TgeneHLA-E

GO:0042270

protection from natural killer cell mediated cytotoxicity

9754572|25631937

TgeneHLA-E

GO:0045953

negative regulation of natural killer cell mediated cytotoxicity

9486650|10799855|17179229|23335510

TgeneHLA-E

GO:0045954

positive regulation of natural killer cell mediated cytotoxicity

23335510

TgeneHLA-E

GO:0050830

defense response to Gram-positive bacterium

25631937

TgeneHLA-E

GO:0051024

positive regulation of immunoglobulin secretion

25631937

TgeneHLA-E

GO:2000566

positive regulation of CD8-positive, alpha-beta T cell proliferation

25631937

TgeneHLA-E

GO:2001187

positive regulation of CD8-positive, alpha-beta T cell activation

28676677



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TM-A7CF-01ADHX16chr6

30638187

-HLA-Echr6

30460181

+


Top

Fusion Gene ORF analysis for DHX16-HLA-E

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000376442ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
5CDS-intronENST00000376442ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
5CDS-intronENST00000376442ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
5CDS-intronENST00000376442ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
5CDS-intronENST00000376442ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
5CDS-intronENST00000376442ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
Frame-shiftENST00000376442ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000376437ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000383576ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000383577ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000414052ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000417308ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000421095ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000424672ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000445379ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000449861ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000451456ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000451748ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000453879ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000458094ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000461170ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000462469ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000477800ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000480637ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000480966ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000481393ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000485518ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000492529ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-3CDSENST00000548461ENST00000376630DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000376437ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000376437ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000376437ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000376437ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000376437ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000376437ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000383576ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000383576ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000383576ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000383576ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000383576ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000383576ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000383577ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000383577ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000383577ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000383577ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000383577ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000383577ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000414052ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000414052ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000414052ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000414052ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000414052ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000414052ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000417308ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000417308ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000417308ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000417308ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000417308ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000417308ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000421095ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000421095ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000421095ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000421095ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000421095ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000421095ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000424672ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000424672ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000424672ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000424672ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000424672ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000424672ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000445379ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000445379ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000445379ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000445379ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000445379ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000445379ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000449861ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000449861ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000449861ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000449861ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000449861ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000449861ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000451456ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000451456ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000451456ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000451456ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000451456ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000451456ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000451748ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000451748ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000451748ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000451748ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000451748ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000451748ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000453879ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000453879ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000453879ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000453879ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000453879ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000453879ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000458094ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000458094ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000458094ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000458094ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000458094ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000458094ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000461170ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000461170ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000461170ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000461170ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000461170ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000461170ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000462469ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000462469ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000462469ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000462469ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000462469ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000462469ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000477800ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000477800ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000477800ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000477800ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000477800ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000477800ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000480637ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000480637ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000480637ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000480637ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000480637ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000480637ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000480966ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000480966ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000480966ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000480966ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000480966ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000480966ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000481393ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000481393ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000481393ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000481393ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000481393ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000481393ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000485518ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000485518ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000485518ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000485518ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000485518ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000485518ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000492529ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000492529ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000492529ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000492529ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000492529ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000492529ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000548461ENST00000383597DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000548461ENST00000415289DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000548461ENST00000415649DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000548461ENST00000425603DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000548461ENST00000427936DHX16chr6

30638187

-HLA-Echr6

30460181

+
intron-intronENST00000548461ENST00000444683DHX16chr6

30638187

-HLA-Echr6

30460181

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DHX16-HLA-E


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DHX16chr630638186-HLA-Echr630460180+1.62E-060.99999833
DHX16chr630638186-HLA-Echr630460180+1.62E-060.99999833


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DHX16-HLA-E


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30638187/:30460181)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DHX16-HLA-E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DHX16-HLA-E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DHX16-HLA-E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DHX16-HLA-E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0036341Schizophrenia5PSYGENET
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0014799Erythroderma, Maculopapular1CTD_human
TgeneC0030437Parakeratosis Variegata1CTD_human
TgeneC0030491Parapsoriasis1CTD_human
TgeneC0033975Psychotic Disorders1PSYGENET
TgeneC0162442Parapsoriasis en Plaques1CTD_human
TgeneC0349204Nonorganic psychosis1PSYGENET