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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C15orf41-SLCO3A1 (FusionGDB2 ID:HG84529TG28232)

Fusion Gene Summary for C15orf41-SLCO3A1

check button Fusion gene summary
Fusion gene informationFusion gene name: C15orf41-SLCO3A1
Fusion gene ID: hg84529tg28232
HgeneTgene
Gene symbol

C15orf41

SLCO3A1

Gene ID

84529

28232

Gene namechromosome 15 open reading frame 41solute carrier organic anion transporter family member 3A1
SynonymsHH114OATP-D|OATP-RP3|OATP3A1|OATPD|OATPRP3|SLC21A11
Cytomap('C15orf41')('SLCO3A1')

15q14

15q26.1

Type of geneprotein-codingprotein-coding
Descriptionprotein C15orf41uncharacterized protein C15orf41solute carrier organic anion transporter family member 3A1PGE1 transporterorganic anion transporter polypeptide-related protein 3organic anion-transporting polypeptide Dsodium-independent organic anion transporter Dsolute carrier family 21 (organic a
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000437989, ENST00000566621, 
ENST00000569302, ENST00000338183, 
ENST00000562489, ENST00000562877, 
ENST00000563167, ENST00000565792, 
ENST00000567389, 
Fusion gene scores* DoF score13 X 6 X 8=62411 X 9 X 7=693
# samples 1311
** MAII scorelog2(13/624*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/693*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C15orf41 [Title/Abstract] AND SLCO3A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC15orf41(36872162)-SLCO3A1(92663695), # samples:3
Anticipated loss of major functional domain due to fusion event.C15orf41-SLCO3A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
C15orf41-SLCO3A1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLCO3A1

GO:0015732

prostaglandin transport

14631946



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-CM-5348-01AC15orf41chr15

36872162

-SLCO3A1chr15

92663695

+
ChimerDB4COADTCGA-CM-5348-01AC15orf41chr15

36872162

+SLCO3A1chr15

92663695

+


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Fusion Gene ORF analysis for C15orf41-SLCO3A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000437989ENST00000555549C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
5CDS-3UTRENST00000566621ENST00000555549C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
5CDS-3UTRENST00000569302ENST00000555549C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
Frame-shiftENST00000437989ENST00000318445C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
Frame-shiftENST00000437989ENST00000424469C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
Frame-shiftENST00000566621ENST00000318445C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
Frame-shiftENST00000566621ENST00000424469C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
Frame-shiftENST00000569302ENST00000318445C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
Frame-shiftENST00000569302ENST00000424469C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3CDSENST00000338183ENST00000318445C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3CDSENST00000338183ENST00000424469C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3CDSENST00000562489ENST00000318445C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3CDSENST00000562489ENST00000424469C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3CDSENST00000562877ENST00000318445C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3CDSENST00000562877ENST00000424469C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3CDSENST00000563167ENST00000318445C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3CDSENST00000563167ENST00000424469C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3CDSENST00000565792ENST00000318445C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3CDSENST00000565792ENST00000424469C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3CDSENST00000567389ENST00000318445C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3CDSENST00000567389ENST00000424469C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3UTRENST00000338183ENST00000555549C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3UTRENST00000562489ENST00000555549C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3UTRENST00000562877ENST00000555549C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3UTRENST00000563167ENST00000555549C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3UTRENST00000565792ENST00000555549C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+
intron-3UTRENST00000567389ENST00000555549C15orf41chr15

36872162

+SLCO3A1chr15

92663695

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for C15orf41-SLCO3A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C15orf41chr1536872162+SLCO3A1chr1592663694+1.12E-070.9999999
C15orf41chr1536872162+SLCO3A1chr1592663694+1.12E-070.9999999


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C15orf41-SLCO3A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:36872162/:92663695)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for C15orf41-SLCO3A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for C15orf41-SLCO3A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C15orf41-SLCO3A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C15orf41-SLCO3A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneC15orf41C3810185ANEMIA, CONGENITAL DYSERYTHROPOIETIC, TYPE Ib4GENOMICS_ENGLAND;UNIPROT
HgeneC15orf41C0002876Congenital dyserythropoietic anemia2CTD_human;GENOMICS_ENGLAND
HgeneC15orf41C0271933Congenital dyserythropoietic anemia, type I1CTD_human;ORPHANET
TgeneC0001973Alcoholic Intoxication, Chronic1PSYGENET