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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CUL3-IRS1 (FusionGDB2 ID:HG8452TG3667) |
Fusion Gene Summary for CUL3-IRS1 |
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Fusion gene information | Fusion gene name: CUL3-IRS1 | Fusion gene ID: hg8452tg3667 | Hgene | Tgene | Gene symbol | CUL3 | IRS1 | Gene ID | 8452 | 3667 |
Gene name | cullin 3 | insulin receptor substrate 1 | |
Synonyms | CUL-3|PHA2E | HIRS-1 | |
Cytomap | ('CUL3')('IRS1') 2q36.2 | 2q36.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cullin-3 | insulin receptor substrate 1IRS-1 | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | . | P35568 | |
Ensembl transtripts involved in fusion gene | ENST00000264414, ENST00000409096, ENST00000409777, ENST00000432260, ENST00000344951, | ||
Fusion gene scores | * DoF score | 12 X 12 X 7=1008 | 1 X 2 X 1=2 |
# samples | 14 | 2 | |
** MAII score | log2(14/1008*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/2*10)=3.32192809488736 | |
Context | PubMed: CUL3 [Title/Abstract] AND IRS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CUL3(225422376)-IRS1(227600966), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CUL3 | GO:0000209 | protein polyubiquitination | 19261606 |
Hgene | CUL3 | GO:0006511 | ubiquitin-dependent protein catabolic process | 25401743|27561354 |
Hgene | CUL3 | GO:0006513 | protein monoubiquitination | 22358839 |
Hgene | CUL3 | GO:0006888 | ER to Golgi vesicle-mediated transport | 22358839 |
Hgene | CUL3 | GO:0016567 | protein ubiquitination | 17543862|19782033|19995937|20389280|23213400 |
Hgene | CUL3 | GO:0031145 | anaphase-promoting complex-dependent catabolic process | 10500095 |
Hgene | CUL3 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 19261606|19782033|20389280 |
Hgene | CUL3 | GO:0071630 | nuclear protein quality control by the ubiquitin-proteasome system | 27561354 |
Tgene | IRS1 | GO:0008286 | insulin receptor signaling pathway | 16516141|23401856 |
Tgene | IRS1 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7782332 |
Tgene | IRS1 | GO:0032868 | response to insulin | 16516141 |
Tgene | IRS1 | GO:0046326 | positive regulation of glucose import | 7493946 |
Tgene | IRS1 | GO:0046628 | positive regulation of insulin receptor signaling pathway | 7493946 |
Tgene | IRS1 | GO:0046676 | negative regulation of insulin secretion | 15572028 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-E9-A1NE-01A | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600965 | - |
ChimerDB4 | BRCA | TCGA-E9-A1NE-01A | CUL3 | chr2 | 225422376 | - | IRS1 | chr2 | 227600966 | - |
ChimerDB4 | BRCA | TCGA-E9-A1NE | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600966 | - |
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Fusion Gene ORF analysis for CUL3-IRS1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000264414 | ENST00000305123 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600965 | - |
5CDS-3UTR | ENST00000264414 | ENST00000305123 | CUL3 | chr2 | 225422376 | - | IRS1 | chr2 | 227600966 | - |
5CDS-3UTR | ENST00000264414 | ENST00000305123 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600966 | - |
5CDS-3UTR | ENST00000409096 | ENST00000305123 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600965 | - |
5CDS-3UTR | ENST00000409096 | ENST00000305123 | CUL3 | chr2 | 225422376 | - | IRS1 | chr2 | 227600966 | - |
5CDS-3UTR | ENST00000409096 | ENST00000305123 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600966 | - |
5CDS-3UTR | ENST00000409777 | ENST00000305123 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600965 | - |
5CDS-3UTR | ENST00000409777 | ENST00000305123 | CUL3 | chr2 | 225422376 | - | IRS1 | chr2 | 227600966 | - |
5CDS-3UTR | ENST00000409777 | ENST00000305123 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600966 | - |
5CDS-intron | ENST00000264414 | ENST00000498335 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600965 | - |
5CDS-intron | ENST00000264414 | ENST00000498335 | CUL3 | chr2 | 225422376 | - | IRS1 | chr2 | 227600966 | - |
5CDS-intron | ENST00000264414 | ENST00000498335 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600966 | - |
5CDS-intron | ENST00000409096 | ENST00000498335 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600965 | - |
5CDS-intron | ENST00000409096 | ENST00000498335 | CUL3 | chr2 | 225422376 | - | IRS1 | chr2 | 227600966 | - |
5CDS-intron | ENST00000409096 | ENST00000498335 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600966 | - |
5CDS-intron | ENST00000409777 | ENST00000498335 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600965 | - |
5CDS-intron | ENST00000409777 | ENST00000498335 | CUL3 | chr2 | 225422376 | - | IRS1 | chr2 | 227600966 | - |
5CDS-intron | ENST00000409777 | ENST00000498335 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600966 | - |
5UTR-3UTR | ENST00000432260 | ENST00000305123 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600965 | - |
5UTR-3UTR | ENST00000432260 | ENST00000305123 | CUL3 | chr2 | 225422376 | - | IRS1 | chr2 | 227600966 | - |
5UTR-3UTR | ENST00000432260 | ENST00000305123 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600966 | - |
5UTR-intron | ENST00000432260 | ENST00000498335 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600965 | - |
5UTR-intron | ENST00000432260 | ENST00000498335 | CUL3 | chr2 | 225422376 | - | IRS1 | chr2 | 227600966 | - |
5UTR-intron | ENST00000432260 | ENST00000498335 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600966 | - |
intron-3UTR | ENST00000344951 | ENST00000305123 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600965 | - |
intron-3UTR | ENST00000344951 | ENST00000305123 | CUL3 | chr2 | 225422376 | - | IRS1 | chr2 | 227600966 | - |
intron-3UTR | ENST00000344951 | ENST00000305123 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600966 | - |
intron-intron | ENST00000344951 | ENST00000498335 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600965 | - |
intron-intron | ENST00000344951 | ENST00000498335 | CUL3 | chr2 | 225422376 | - | IRS1 | chr2 | 227600966 | - |
intron-intron | ENST00000344951 | ENST00000498335 | CUL3 | chr2 | 225422375 | - | IRS1 | chr2 | 227600966 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CUL3-IRS1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CUL3-IRS1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:225422376/:227600966) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | IRS1 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). {ECO:0000250, ECO:0000269|PubMed:16878150}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CUL3-IRS1 |
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Fusion Gene PPI Analysis for CUL3-IRS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CUL3-IRS1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CUL3-IRS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CUL3 | C0025202 | melanoma | 1 | CTD_human |
Hgene | CUL3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | CUL3 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Hgene | CUL3 | C1535926 | Neurodevelopmental Disorders | 1 | CTD_human |
Hgene | CUL3 | C3469606 | PSEUDOHYPOALDOSTERONISM, TYPE IIE | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 9 | CTD_human;UNIPROT | |
Tgene | C2239176 | Liver carcinoma | 2 | CTD_human | |
Tgene | C0002152 | Alloxan Diabetes | 1 | CTD_human | |
Tgene | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human | |
Tgene | C0010054 | Coronary Arteriosclerosis | 1 | CTD_human | |
Tgene | C0010068 | Coronary heart disease | 1 | CTD_human | |
Tgene | C0011849 | Diabetes Mellitus | 1 | CTD_human | |
Tgene | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human | |
Tgene | C0020459 | Hyperinsulinism | 1 | CTD_human | |
Tgene | C0020473 | Hyperlipidemia | 1 | CTD_human | |
Tgene | C0021655 | Insulin Resistance | 1 | CTD_human | |
Tgene | C0028754 | Obesity | 1 | CTD_human | |
Tgene | C0032927 | Precancerous Conditions | 1 | CTD_human | |
Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
Tgene | C0038433 | Streptozotocin Diabetes | 1 | CTD_human | |
Tgene | C0282313 | Condition, Preneoplastic | 1 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
Tgene | C0920563 | Insulin Sensitivity | 1 | CTD_human | |
Tgene | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human | |
Tgene | C1257963 | Endogenous Hyperinsulinism | 1 | CTD_human | |
Tgene | C1257964 | Exogenous Hyperinsulinism | 1 | CTD_human | |
Tgene | C1257965 | Compensatory Hyperinsulinemia | 1 | CTD_human | |
Tgene | C1706412 | Lipidemias | 1 | CTD_human | |
Tgene | C1956346 | Coronary Artery Disease | 1 | CTD_human |