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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HIATL1-ZCCHC6 (FusionGDB2 ID:HG84641TG79670)

Fusion Gene Summary for HIATL1-ZCCHC6

check button Fusion gene summary
Fusion gene informationFusion gene name: HIATL1-ZCCHC6
Fusion gene ID: hg84641tg79670
HgeneTgene
Gene symbol

HIATL1

ZCCHC6

Gene ID

84641

79670

Gene namemajor facilitator superfamily domain containing 14Bterminal uridylyl transferase 7
SynonymsHIATL1PAPD6|TENT3B|ZCCHC6
Cytomap('HIATL1')('ZCCHC6')

9q22.32

9q21.33

Type of geneprotein-codingprotein-coding
Descriptionhippocampus abundant transcript-like protein 1hippocampus abundant transcript-like 1terminal uridylyltransferase 7PAP associated domain containing 6TUTase 7zinc finger CCHC domain-containing protein 6zinc finger CCHC-type containing 6zinc finger, CCHC domain containing 6
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000375344, ENST00000428393, 
Fusion gene scores* DoF score5 X 4 X 5=1008 X 7 X 6=336
# samples 59
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HIATL1 [Title/Abstract] AND ZCCHC6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHIATL1(97177535)-ZCCHC6(88903659), # samples:1
Anticipated loss of major functional domain due to fusion event.HIATL1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HIATL1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HIATL1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HIATL1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HIATL1-ZCCHC6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZCCHC6

GO:0010526

negative regulation of transposition, RNA-mediated

30122351

TgeneZCCHC6

GO:0010586

miRNA metabolic process

25979828

TgeneZCCHC6

GO:0031054

pre-miRNA processing

25979828

TgeneZCCHC6

GO:0031123

RNA 3'-end processing

17353264

TgeneZCCHC6

GO:0071076

RNA 3' uridylation

28671666


check buttonFusion gene breakpoints across HIATL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZCCHC6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-5966HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-


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Fusion Gene ORF analysis for HIATL1-ZCCHC6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000375344ENST00000375947HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
5CDS-intronENST00000375344ENST00000375948HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
5CDS-intronENST00000375344ENST00000469004HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
5CDS-intronENST00000428393ENST00000375947HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
5CDS-intronENST00000428393ENST00000375948HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
5CDS-intronENST00000428393ENST00000469004HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
Frame-shiftENST00000375344ENST00000277141HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
Frame-shiftENST00000375344ENST00000375957HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
Frame-shiftENST00000428393ENST00000277141HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
Frame-shiftENST00000428393ENST00000375957HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
In-frameENST00000375344ENST00000375960HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
In-frameENST00000375344ENST00000375961HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
In-frameENST00000375344ENST00000375963HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
In-frameENST00000428393ENST00000375960HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
In-frameENST00000428393ENST00000375961HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-
In-frameENST00000428393ENST00000375963HIATL1chr9

97177535

+ZCCHC6chr9

88903659

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000375344HIATL1chr997177535+ENST00000375961ZCCHC6chr988903659-14854733980133
ENST00000375344HIATL1chr997177535+ENST00000375960ZCCHC6chr988903659-14854733980133
ENST00000375344HIATL1chr997177535+ENST00000375963ZCCHC6chr988903659-1259473501121126
ENST00000428393HIATL1chr997177535+ENST00000375961ZCCHC6chr988903659-10574546426466
ENST00000428393HIATL1chr997177535+ENST00000375960ZCCHC6chr988903659-10574546426466
ENST00000428393HIATL1chr997177535+ENST00000375963ZCCHC6chr988903659-8314546426466

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375344ENST00000375961HIATL1chr997177535+ZCCHC6chr988903659-0.589196440.4108036
ENST00000375344ENST00000375960HIATL1chr997177535+ZCCHC6chr988903659-0.589196440.4108036
ENST00000375344ENST00000375963HIATL1chr997177535+ZCCHC6chr988903659-0.52225250.47774744
ENST00000428393ENST00000375961HIATL1chr997177535+ZCCHC6chr988903659-0.87606180.12393816
ENST00000428393ENST00000375960HIATL1chr997177535+ZCCHC6chr988903659-0.87606180.12393816
ENST00000428393ENST00000375963HIATL1chr997177535+ZCCHC6chr988903659-0.886983160.11301685

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Fusion Genomic Features for HIATL1-ZCCHC6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for HIATL1-ZCCHC6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:97177535/chr9:88903659)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+2121_4968507.0Topological domainExtracellular
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+21250_7068507.0TransmembraneHelical
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037595710121367_1370373396.0Compositional biasNote=Poly-Arg
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759571012815_936373396.0Compositional biasNote=Glu-rich
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596018201367_137012371260.0Compositional biasNote=Poly-Arg
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037595710121233_1286373396.0DomainNote=PAP-associated 2
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759571012551_600373396.0DomainNote=PAP-associated 1
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037595710121047_1050373396.0RegionUTP binding
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037595710121057_1060373396.0RegionUTP binding
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037595710121170_1174373396.0RegionUTP binding
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759571012951_1495373396.0RegionSufficient for monouridylation activity
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037595710121345_1362373396.0Zinc fingerCCHC-type 2
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037595710121451_1468373396.0Zinc fingerCCHC-type 3
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759571012963_980373396.0Zinc fingerCCHC-type 1
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596018201345_136212371260.0Zinc fingerCCHC-type 2
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596018201451_146812371260.0Zinc fingerCCHC-type 3
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596124261451_146814351458.0Zinc fingerCCHC-type 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212104_11168507.0Topological domainExtracellular
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212133_13468507.0Topological domainCytoplasmic
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212156_16868507.0Topological domainExtracellular
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212190_19668507.0Topological domainCytoplasmic
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212218_25568507.0Topological domainExtracellular
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212277_28168507.0Topological domainCytoplasmic
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212303_31968507.0Topological domainExtracellular
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212341_34168507.0Topological domainCytoplasmic
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212363_38768507.0Topological domainExtracellular
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212409_42868507.0Topological domainCytoplasmic
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212450_50668507.0Topological domainExtracellular
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+21271_8268507.0Topological domainCytoplasmic
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212112_13268507.0TransmembraneHelical
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212135_15568507.0TransmembraneHelical
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212169_18968507.0TransmembraneHelical
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212197_21768507.0TransmembraneHelical
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212256_27668507.0TransmembraneHelical
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212282_30268507.0TransmembraneHelical
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212320_34068507.0TransmembraneHelical
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212342_36268507.0TransmembraneHelical
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212388_40868507.0TransmembraneHelical
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+212429_44968507.0TransmembraneHelical
HgeneHIATL1chr9:97177535chr9:88903659ENST00000375344+21283_10368507.0TransmembraneHelical
TgeneZCCHC6chr9:97177535chr9:88903659ENST00000375957101220_23373396.0Compositional biasNote=Poly-Asp
TgeneZCCHC6chr9:97177535chr9:88903659ENST00000375960182020_2312371260.0Compositional biasNote=Poly-Asp
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759601820815_93612371260.0Compositional biasNote=Glu-rich
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596124261367_137014351458.0Compositional biasNote=Poly-Arg
TgeneZCCHC6chr9:97177535chr9:88903659ENST00000375961242620_2314351458.0Compositional biasNote=Poly-Asp
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759612426815_93614351458.0Compositional biasNote=Glu-rich
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596325271367_137014731496.0Compositional biasNote=Poly-Arg
TgeneZCCHC6chr9:97177535chr9:88903659ENST00000375963252720_2314731496.0Compositional biasNote=Poly-Asp
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759632527815_93614731496.0Compositional biasNote=Glu-rich
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596018201233_128612371260.0DomainNote=PAP-associated 2
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759601820551_60012371260.0DomainNote=PAP-associated 1
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596124261233_128614351458.0DomainNote=PAP-associated 2
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759612426551_60014351458.0DomainNote=PAP-associated 1
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596325271233_128614731496.0DomainNote=PAP-associated 2
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759632527551_60014731496.0DomainNote=PAP-associated 1
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596018201047_105012371260.0RegionUTP binding
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596018201057_106012371260.0RegionUTP binding
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596018201170_117412371260.0RegionUTP binding
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759601820951_149512371260.0RegionSufficient for monouridylation activity
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596124261047_105014351458.0RegionUTP binding
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596124261057_106014351458.0RegionUTP binding
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596124261170_117414351458.0RegionUTP binding
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759612426951_149514351458.0RegionSufficient for monouridylation activity
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596325271047_105014731496.0RegionUTP binding
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596325271057_106014731496.0RegionUTP binding
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596325271170_117414731496.0RegionUTP binding
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759632527951_149514731496.0RegionSufficient for monouridylation activity
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759571012244_274373396.0Zinc fingerMatrin-type
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759601820244_27412371260.0Zinc fingerMatrin-type
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759601820963_98012371260.0Zinc fingerCCHC-type 1
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596124261345_136214351458.0Zinc fingerCCHC-type 2
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759612426244_27414351458.0Zinc fingerMatrin-type
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759612426963_98014351458.0Zinc fingerCCHC-type 1
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596325271345_136214731496.0Zinc fingerCCHC-type 2
TgeneZCCHC6chr9:97177535chr9:88903659ENST0000037596325271451_146814731496.0Zinc fingerCCHC-type 3
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759632527244_27414731496.0Zinc fingerMatrin-type
TgeneZCCHC6chr9:97177535chr9:88903659ENST000003759632527963_98014731496.0Zinc fingerCCHC-type 1


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Fusion Gene Sequence for HIATL1-ZCCHC6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36286_36286_1_HIATL1-ZCCHC6_HIATL1_chr9_97177535_ENST00000375344_ZCCHC6_chr9_88903659_ENST00000375960_length(transcript)=1485nt_BP=473nt
CCCGCCCCTGACGCCGCCGGTAACTGCGAGAGTCGGGGTCGGTGCGGTTTGATAAGTGGTCGGTTCCTGGAGCTGCGGTCTTCTGCTAGC
CTGATCCGCAGCTTCAGCCTCCGCCGCCTCCTCAGCCCTCGGCGCCGCCGCTGGCGCCGCCGCCTGACCCGCAGGCCGCCGCGGGCCGCA
GAGCCCATGAGGGCGCGGGCACCGCCGCCGCCTCCGCGGCGTCGCCGTCGTCCCGGAGCGCCCCGGGCTGGCGCGGGCATGGCCGCGGCA
TGAGCGTGGAGCCGCCGCCGGAGCTGGAGGAGAAGGCGGCGTCGGAGCCCGAGGCGGGAGCCATGCCGGAGAAGCGCGCGGGCGCGCAGG
CCGCGGGGAGCACCTGGCTACAAGGCTTTGGCCGACCAAGTGTGTACCATGCTGCTATTGTCATCTTCCTTGAATTCTTTGCGTGGGGCC
TGTTGACAACTCCAATGTTGACTGTAGCCTTTCCAGTAAATATATGACTCAGGGAAAAGCCTCAGCGAAGAGGACCCAGCAGGAATCATG
AGGGAAGGAAAATGCAGCACTCTAAATGGCCACTCAGGCGTTCCTATTCACTCGGAAAATTAGGTTCATTTCACAGGACACAGCAGTGTA
GATCAGGCTTCAACTTAACATTTAAGGGAAATGTCAGATTTTTTTTTAATTTAATGAAATTGTTAATGAGGAAAAATTTTTAATATAGTC
TTATCTACCACACATCCCCATAGATTTAAGGATTTTAATAGAAAGACATGATGTATGTATTTAAGCCACGTTAAAAGAAAAAATATAACT
ATGGACCGGTATTCAGTGAATACAGTTTCATGGTTTTTAATTCTTTCAAAGCACATTAAAAATGGTGTGCTGATAAACCCCAAGTAAATT
AACCCTTTTTCCGTATAAATCCATTTTTTGTTTTGAAGAGGGGAAATTATATTTATTGTTGTTTACTGAATCCTGGTGTGAAAGCATATC
AGATATGTATGAACTGCTACTGCTGTACTTCCGATTTACGGACATCATTTTATTGCTATTTGTAGACGTGATAACATGAACATGAGTACC
TATTTATGTGGGCCTTCAGTGGATGGGCAGTGCCACTCAGGTCTCTGGGGTTTCCCTCTCTAATTTTAAGTAAATTGACATATAACTACT
ATGCTTATAAAAATGAAGTAAGGAAAACAAGTAGTCCTGTTTGCCACTAAAAACATTTTCAAAGGAAAAATAAAATGAAAGTACTTTTTA
CTTTTTATGATACTCAGAAATTAGGATGAAGAACTTTTAAAATTGCTGAAGATCAAAGAGGTTATCTCTGCCAGTCACAAGTGTGGCTGG
TGTCATTCTGGGTCTGACTGGAGCCCTCCTGGACTGTTTCTTTAATTTCAAAAGCCCTGCAGACATAGTACCTGGTCAGAACTATGCCTC

>36286_36286_1_HIATL1-ZCCHC6_HIATL1_chr9_97177535_ENST00000375344_ZCCHC6_chr9_88903659_ENST00000375960_length(amino acids)=133AA_BP=
MVGQSLVARCSPRPARPRASPAWLPPRAPTPPSPPAPAAAPRSCRGHARASPGRSGTTATPRRRRRCPRPHGLCGPRRPAGQAAAPAAAP

--------------------------------------------------------------
>36286_36286_2_HIATL1-ZCCHC6_HIATL1_chr9_97177535_ENST00000375344_ZCCHC6_chr9_88903659_ENST00000375961_length(transcript)=1485nt_BP=473nt
CCCGCCCCTGACGCCGCCGGTAACTGCGAGAGTCGGGGTCGGTGCGGTTTGATAAGTGGTCGGTTCCTGGAGCTGCGGTCTTCTGCTAGC
CTGATCCGCAGCTTCAGCCTCCGCCGCCTCCTCAGCCCTCGGCGCCGCCGCTGGCGCCGCCGCCTGACCCGCAGGCCGCCGCGGGCCGCA
GAGCCCATGAGGGCGCGGGCACCGCCGCCGCCTCCGCGGCGTCGCCGTCGTCCCGGAGCGCCCCGGGCTGGCGCGGGCATGGCCGCGGCA
TGAGCGTGGAGCCGCCGCCGGAGCTGGAGGAGAAGGCGGCGTCGGAGCCCGAGGCGGGAGCCATGCCGGAGAAGCGCGCGGGCGCGCAGG
CCGCGGGGAGCACCTGGCTACAAGGCTTTGGCCGACCAAGTGTGTACCATGCTGCTATTGTCATCTTCCTTGAATTCTTTGCGTGGGGCC
TGTTGACAACTCCAATGTTGACTGTAGCCTTTCCAGTAAATATATGACTCAGGGAAAAGCCTCAGCGAAGAGGACCCAGCAGGAATCATG
AGGGAAGGAAAATGCAGCACTCTAAATGGCCACTCAGGCGTTCCTATTCACTCGGAAAATTAGGTTCATTTCACAGGACACAGCAGTGTA
GATCAGGCTTCAACTTAACATTTAAGGGAAATGTCAGATTTTTTTTTAATTTAATGAAATTGTTAATGAGGAAAAATTTTTAATATAGTC
TTATCTACCACACATCCCCATAGATTTAAGGATTTTAATAGAAAGACATGATGTATGTATTTAAGCCACGTTAAAAGAAAAAATATAACT
ATGGACCGGTATTCAGTGAATACAGTTTCATGGTTTTTAATTCTTTCAAAGCACATTAAAAATGGTGTGCTGATAAACCCCAAGTAAATT
AACCCTTTTTCCGTATAAATCCATTTTTTGTTTTGAAGAGGGGAAATTATATTTATTGTTGTTTACTGAATCCTGGTGTGAAAGCATATC
AGATATGTATGAACTGCTACTGCTGTACTTCCGATTTACGGACATCATTTTATTGCTATTTGTAGACGTGATAACATGAACATGAGTACC
TATTTATGTGGGCCTTCAGTGGATGGGCAGTGCCACTCAGGTCTCTGGGGTTTCCCTCTCTAATTTTAAGTAAATTGACATATAACTACT
ATGCTTATAAAAATGAAGTAAGGAAAACAAGTAGTCCTGTTTGCCACTAAAAACATTTTCAAAGGAAAAATAAAATGAAAGTACTTTTTA
CTTTTTATGATACTCAGAAATTAGGATGAAGAACTTTTAAAATTGCTGAAGATCAAAGAGGTTATCTCTGCCAGTCACAAGTGTGGCTGG
TGTCATTCTGGGTCTGACTGGAGCCCTCCTGGACTGTTTCTTTAATTTCAAAAGCCCTGCAGACATAGTACCTGGTCAGAACTATGCCTC

>36286_36286_2_HIATL1-ZCCHC6_HIATL1_chr9_97177535_ENST00000375344_ZCCHC6_chr9_88903659_ENST00000375961_length(amino acids)=133AA_BP=
MVGQSLVARCSPRPARPRASPAWLPPRAPTPPSPPAPAAAPRSCRGHARASPGRSGTTATPRRRRRCPRPHGLCGPRRPAGQAAAPAAAP

--------------------------------------------------------------
>36286_36286_3_HIATL1-ZCCHC6_HIATL1_chr9_97177535_ENST00000375344_ZCCHC6_chr9_88903659_ENST00000375963_length(transcript)=1259nt_BP=473nt
CCCGCCCCTGACGCCGCCGGTAACTGCGAGAGTCGGGGTCGGTGCGGTTTGATAAGTGGTCGGTTCCTGGAGCTGCGGTCTTCTGCTAGC
CTGATCCGCAGCTTCAGCCTCCGCCGCCTCCTCAGCCCTCGGCGCCGCCGCTGGCGCCGCCGCCTGACCCGCAGGCCGCCGCGGGCCGCA
GAGCCCATGAGGGCGCGGGCACCGCCGCCGCCTCCGCGGCGTCGCCGTCGTCCCGGAGCGCCCCGGGCTGGCGCGGGCATGGCCGCGGCA
TGAGCGTGGAGCCGCCGCCGGAGCTGGAGGAGAAGGCGGCGTCGGAGCCCGAGGCGGGAGCCATGCCGGAGAAGCGCGCGGGCGCGCAGG
CCGCGGGGAGCACCTGGCTACAAGGCTTTGGCCGACCAAGTGTGTACCATGCTGCTATTGTCATCTTCCTTGAATTCTTTGCGTGGGGCC
TGTTGACAACTCCAATGTTGACTGTAGCCTTTCCAGTAAATATATGACTCAGGGAAAAGCCTCAGCGAAGAGGACCCAGCAGGAATCATG
AGGGAAGGAAAATGCAGCACTCTAAATGGCCACTCAGGCGTTCCTATTCACTCGGAAAATTAGGTTCATTTCACAGGACACAGCAGTGTA
GATCAGGCTTCAACTTAACATTTAAGGGAAATGTCAGATTTTTTTTTAATTTAATGAAATTGTTAATGAGGAAAAATTTTTAATATAGTC
TTATCTACCACACATCCCCATAGATTTAAGGATTTTAATAGAAAGACATGATGTATGTATTTAAGCCACGTTAAAAGAAAAAATATAACT
ATGGACCGGTATTCAGTGAATACAGTTTCATGGTTTTTAATTCTTTCAAAGCACATTAAAAATGGTGTGCTGATAAACCCCAAGTAAATT
AACCCTTTTTCCGTATAAATCCATTTTTTGTTTTGAAGAGGGGAAATTATATTTATTGTTGTTTACTGAATCCTGGTGTGAAAGCATATC
AGATATGTATGAACTGCTACTGCTGTACTTCCGATTTACGGACATCATTTTATTGCTATTTGTAGACGTGATAACATGAACATGAGTACC
TATTTATGTGGGCCTTCAGTGGATGGGCAGTGCCACTCAGGTCTCTGGGGTTTCCCTCTCTAATTTTAAGTAAATTGACATATAACTACT

>36286_36286_3_HIATL1-ZCCHC6_HIATL1_chr9_97177535_ENST00000375344_ZCCHC6_chr9_88903659_ENST00000375963_length(amino acids)=126AA_BP=
MSHIFTGKATVNIGVVNRPHAKNSRKMTIAAWYTLGRPKPCSQVLPAACAPARFSGMAPASGSDAAFSSSSGGGSTLMPRPCPRQPGALR

--------------------------------------------------------------
>36286_36286_4_HIATL1-ZCCHC6_HIATL1_chr9_97177535_ENST00000428393_ZCCHC6_chr9_88903659_ENST00000375960_length(transcript)=1057nt_BP=45nt
CTTGAATTCTTTGCGTGGGGCCTGTTGACAACTCCAATGTTGACTGTAGCCTTTCCAGTAAATATATGACTCAGGGAAAAGCCTCAGCGA
AGAGGACCCAGCAGGAATCATGAGGGAAGGAAAATGCAGCACTCTAAATGGCCACTCAGGCGTTCCTATTCACTCGGAAAATTAGGTTCA
TTTCACAGGACACAGCAGTGTAGATCAGGCTTCAACTTAACATTTAAGGGAAATGTCAGATTTTTTTTTAATTTAATGAAATTGTTAATG
AGGAAAAATTTTTAATATAGTCTTATCTACCACACATCCCCATAGATTTAAGGATTTTAATAGAAAGACATGATGTATGTATTTAAGCCA
CGTTAAAAGAAAAAATATAACTATGGACCGGTATTCAGTGAATACAGTTTCATGGTTTTTAATTCTTTCAAAGCACATTAAAAATGGTGT
GCTGATAAACCCCAAGTAAATTAACCCTTTTTCCGTATAAATCCATTTTTTGTTTTGAAGAGGGGAAATTATATTTATTGTTGTTTACTG
AATCCTGGTGTGAAAGCATATCAGATATGTATGAACTGCTACTGCTGTACTTCCGATTTACGGACATCATTTTATTGCTATTTGTAGACG
TGATAACATGAACATGAGTACCTATTTATGTGGGCCTTCAGTGGATGGGCAGTGCCACTCAGGTCTCTGGGGTTTCCCTCTCTAATTTTA
AGTAAATTGACATATAACTACTATGCTTATAAAAATGAAGTAAGGAAAACAAGTAGTCCTGTTTGCCACTAAAAACATTTTCAAAGGAAA
AATAAAATGAAAGTACTTTTTACTTTTTATGATACTCAGAAATTAGGATGAAGAACTTTTAAAATTGCTGAAGATCAAAGAGGTTATCTC
TGCCAGTCACAAGTGTGGCTGGTGTCATTCTGGGTCTGACTGGAGCCCTCCTGGACTGTTTCTTTAATTTCAAAAGCCCTGCAGACATAG

>36286_36286_4_HIATL1-ZCCHC6_HIATL1_chr9_97177535_ENST00000428393_ZCCHC6_chr9_88903659_ENST00000375960_length(amino acids)=66AA_BP=

--------------------------------------------------------------
>36286_36286_5_HIATL1-ZCCHC6_HIATL1_chr9_97177535_ENST00000428393_ZCCHC6_chr9_88903659_ENST00000375961_length(transcript)=1057nt_BP=45nt
CTTGAATTCTTTGCGTGGGGCCTGTTGACAACTCCAATGTTGACTGTAGCCTTTCCAGTAAATATATGACTCAGGGAAAAGCCTCAGCGA
AGAGGACCCAGCAGGAATCATGAGGGAAGGAAAATGCAGCACTCTAAATGGCCACTCAGGCGTTCCTATTCACTCGGAAAATTAGGTTCA
TTTCACAGGACACAGCAGTGTAGATCAGGCTTCAACTTAACATTTAAGGGAAATGTCAGATTTTTTTTTAATTTAATGAAATTGTTAATG
AGGAAAAATTTTTAATATAGTCTTATCTACCACACATCCCCATAGATTTAAGGATTTTAATAGAAAGACATGATGTATGTATTTAAGCCA
CGTTAAAAGAAAAAATATAACTATGGACCGGTATTCAGTGAATACAGTTTCATGGTTTTTAATTCTTTCAAAGCACATTAAAAATGGTGT
GCTGATAAACCCCAAGTAAATTAACCCTTTTTCCGTATAAATCCATTTTTTGTTTTGAAGAGGGGAAATTATATTTATTGTTGTTTACTG
AATCCTGGTGTGAAAGCATATCAGATATGTATGAACTGCTACTGCTGTACTTCCGATTTACGGACATCATTTTATTGCTATTTGTAGACG
TGATAACATGAACATGAGTACCTATTTATGTGGGCCTTCAGTGGATGGGCAGTGCCACTCAGGTCTCTGGGGTTTCCCTCTCTAATTTTA
AGTAAATTGACATATAACTACTATGCTTATAAAAATGAAGTAAGGAAAACAAGTAGTCCTGTTTGCCACTAAAAACATTTTCAAAGGAAA
AATAAAATGAAAGTACTTTTTACTTTTTATGATACTCAGAAATTAGGATGAAGAACTTTTAAAATTGCTGAAGATCAAAGAGGTTATCTC
TGCCAGTCACAAGTGTGGCTGGTGTCATTCTGGGTCTGACTGGAGCCCTCCTGGACTGTTTCTTTAATTTCAAAAGCCCTGCAGACATAG

>36286_36286_5_HIATL1-ZCCHC6_HIATL1_chr9_97177535_ENST00000428393_ZCCHC6_chr9_88903659_ENST00000375961_length(amino acids)=66AA_BP=

--------------------------------------------------------------
>36286_36286_6_HIATL1-ZCCHC6_HIATL1_chr9_97177535_ENST00000428393_ZCCHC6_chr9_88903659_ENST00000375963_length(transcript)=831nt_BP=45nt
CTTGAATTCTTTGCGTGGGGCCTGTTGACAACTCCAATGTTGACTGTAGCCTTTCCAGTAAATATATGACTCAGGGAAAAGCCTCAGCGA
AGAGGACCCAGCAGGAATCATGAGGGAAGGAAAATGCAGCACTCTAAATGGCCACTCAGGCGTTCCTATTCACTCGGAAAATTAGGTTCA
TTTCACAGGACACAGCAGTGTAGATCAGGCTTCAACTTAACATTTAAGGGAAATGTCAGATTTTTTTTTAATTTAATGAAATTGTTAATG
AGGAAAAATTTTTAATATAGTCTTATCTACCACACATCCCCATAGATTTAAGGATTTTAATAGAAAGACATGATGTATGTATTTAAGCCA
CGTTAAAAGAAAAAATATAACTATGGACCGGTATTCAGTGAATACAGTTTCATGGTTTTTAATTCTTTCAAAGCACATTAAAAATGGTGT
GCTGATAAACCCCAAGTAAATTAACCCTTTTTCCGTATAAATCCATTTTTTGTTTTGAAGAGGGGAAATTATATTTATTGTTGTTTACTG
AATCCTGGTGTGAAAGCATATCAGATATGTATGAACTGCTACTGCTGTACTTCCGATTTACGGACATCATTTTATTGCTATTTGTAGACG
TGATAACATGAACATGAGTACCTATTTATGTGGGCCTTCAGTGGATGGGCAGTGCCACTCAGGTCTCTGGGGTTTCCCTCTCTAATTTTA
AGTAAATTGACATATAACTACTATGCTTATAAAAATGAAGTAAGGAAAACAAGTAGTCCTGTTTGCCACTAAAAACATTTTCAAAGGAAA

>36286_36286_6_HIATL1-ZCCHC6_HIATL1_chr9_97177535_ENST00000428393_ZCCHC6_chr9_88903659_ENST00000375963_length(amino acids)=66AA_BP=

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HIATL1-ZCCHC6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HIATL1-ZCCHC6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HIATL1-ZCCHC6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource