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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:DPY30-MCU (FusionGDB2 ID:HG84661TG90550) |
Fusion Gene Summary for DPY30-MCU |
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Fusion gene information | Fusion gene name: DPY30-MCU | Fusion gene ID: hg84661tg90550 | Hgene | Tgene | Gene symbol | DPY30 | MCU | Gene ID | 84661 | 90550 |
Gene name | dpy-30 histone methyltransferase complex regulatory subunit | mitochondrial calcium uniporter | |
Synonyms | Cps25|HDPY-30|Saf19 | C10orf42|CCDC109A|HsMCU | |
Cytomap | ('DPY30')('MCU') 2p22.3 | 10q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein dpy-30 homologdpy-30 homologdpy-30-like proteindpy-30L | calcium uniporter protein, mitochondrialcoiled-coil domain-containing protein 109A | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9C005 | . | |
Ensembl transtripts involved in fusion gene | ENST00000446765, ENST00000295066, ENST00000342166, | ||
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 7 X 5 X 5=175 |
# samples | 5 | 7 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DPY30 [Title/Abstract] AND MCU [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DPY30(32142995)-MCU(74594117), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DPY30 | GO:0051568 | histone H3-K4 methylation | 19556245 |
Tgene | MCU | GO:0006851 | mitochondrial calcium ion transmembrane transport | 21685888|24560927 |
Tgene | MCU | GO:0019722 | calcium-mediated signaling | 21685886|21685888 |
Tgene | MCU | GO:0036444 | calcium import into the mitochondrion | 22925203 |
Tgene | MCU | GO:0051259 | protein complex oligomerization | 21685886 |
Tgene | MCU | GO:0051561 | positive regulation of mitochondrial calcium ion concentration | 21685888|24560927 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | ACC | TCGA-OR-A5K5-01A | DPY30 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
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Fusion Gene ORF analysis for DPY30-MCU |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000446765 | ENST00000357157 | DPY30 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
5UTR-3CDS | ENST00000446765 | ENST00000373053 | DPY30 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
5UTR-3CDS | ENST00000446765 | ENST00000536019 | DPY30 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
5UTR-intron | ENST00000446765 | ENST00000605416 | DPY30 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
intron-3CDS | ENST00000295066 | ENST00000357157 | DPY30 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
intron-3CDS | ENST00000295066 | ENST00000373053 | DPY30 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
intron-3CDS | ENST00000295066 | ENST00000536019 | DPY30 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
intron-3CDS | ENST00000342166 | ENST00000357157 | DPY30 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
intron-3CDS | ENST00000342166 | ENST00000373053 | DPY30 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
intron-3CDS | ENST00000342166 | ENST00000536019 | DPY30 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
intron-intron | ENST00000295066 | ENST00000605416 | DPY30 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
intron-intron | ENST00000342166 | ENST00000605416 | DPY30 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DPY30-MCU |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
DPY30 | chr2 | 32142994 | - | MCU | chr10 | 74594116 | + | 0.002458094 | 0.9975419 |
DPY30 | chr2 | 32142994 | - | MCU | chr10 | 74594116 | + | 0.002458094 | 0.9975419 |
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Fusion Protein Features for DPY30-MCU |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32142995/:74594117) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
DPY30 | . |
FUNCTION: As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. {ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:19651892, ECO:0000269|PubMed:21335234}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DPY30-MCU |
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Fusion Gene PPI Analysis for DPY30-MCU |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DPY30-MCU |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DPY30-MCU |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |