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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDC42BPA-WWOX (FusionGDB2 ID:HG8476TG51741)

Fusion Gene Summary for CDC42BPA-WWOX

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC42BPA-WWOX
Fusion gene ID: hg8476tg51741
HgeneTgene
Gene symbol

CDC42BPA

WWOX

Gene ID

8476

51741

Gene nameCDC42 binding protein kinase alphaWW domain containing oxidoreductase
SynonymsMRCK|MRCKA|PK428D16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
Cytomap('CDC42BPA')('WWOX')

1q42.13

16q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase MRCK alphaCDC42 binding protein kinase alpha (DMPK-like)CDC42 binding protein kinase betamyotonic dystrophy kinase-related CDC42-binding protein kinase alphamyotonic dystrophy protein kinase-like alphaser-thr protein kWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000334218, ENST00000366764, 
ENST00000366765, ENST00000366766, 
ENST00000366767, ENST00000366769, 
ENST00000535525, ENST00000488131, 
Fusion gene scores* DoF score14 X 12 X 9=151230 X 23 X 10=6900
# samples 1536
** MAII scorelog2(15/1512*10)=-3.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/6900*10)=-4.26052755022322
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDC42BPA [Title/Abstract] AND WWOX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDC42BPA(227504706)-WWOX(79245505), # samples:3
Anticipated loss of major functional domain due to fusion event.CDC42BPA-WWOX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42BPA-WWOX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42BPA-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42BPA-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42BPA-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CDC42BPA-WWOX seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CDC42BPA-WWOX seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
CDC42BPA-WWOX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CDC42BPA-WWOX seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC42BPA

GO:0006468

protein phosphorylation

9092543

HgeneCDC42BPA

GO:0031532

actin cytoskeleton reorganization

9418861

TgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

TgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check buttonFusion gene breakpoints across CDC42BPA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across WWOX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A6TC-01ACDC42BPAchr1

227504706

-WWOXchr16

79245505

+


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Fusion Gene ORF analysis for CDC42BPA-WWOX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000334218ENST00000355860CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000334218ENST00000408984CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000334218ENST00000565791CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000334218ENST00000569818CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366764ENST00000355860CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366764ENST00000408984CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366764ENST00000565791CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366764ENST00000569818CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366765ENST00000355860CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366765ENST00000408984CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366765ENST00000565791CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366765ENST00000569818CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366766ENST00000355860CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366766ENST00000408984CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366766ENST00000565791CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366766ENST00000569818CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366767ENST00000355860CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366767ENST00000408984CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366767ENST00000565791CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366767ENST00000569818CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366769ENST00000355860CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366769ENST00000408984CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366769ENST00000565791CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000366769ENST00000569818CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000535525ENST00000355860CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000535525ENST00000408984CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000535525ENST00000565791CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
5CDS-intronENST00000535525ENST00000569818CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000334218ENST00000402655CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000334218ENST00000406884CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000334218ENST00000566780CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366764ENST00000402655CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366764ENST00000406884CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366764ENST00000566780CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366765ENST00000402655CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366765ENST00000406884CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366765ENST00000566780CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366766ENST00000402655CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366766ENST00000406884CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366766ENST00000566780CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366767ENST00000402655CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366767ENST00000406884CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366767ENST00000566780CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366769ENST00000402655CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366769ENST00000406884CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000366769ENST00000566780CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000535525ENST00000402655CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000535525ENST00000406884CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
Frame-shiftENST00000535525ENST00000566780CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
In-frameENST00000334218ENST00000539474CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
In-frameENST00000366764ENST00000539474CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
In-frameENST00000366765ENST00000539474CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
In-frameENST00000366766ENST00000539474CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
In-frameENST00000366767ENST00000539474CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
In-frameENST00000366769ENST00000539474CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
In-frameENST00000535525ENST00000539474CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
intron-3CDSENST00000488131ENST00000402655CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
intron-3CDSENST00000488131ENST00000406884CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
intron-3CDSENST00000488131ENST00000539474CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
intron-3CDSENST00000488131ENST00000566780CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
intron-intronENST00000488131ENST00000355860CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
intron-intronENST00000488131ENST00000408984CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
intron-intronENST00000488131ENST00000565791CDC42BPAchr1

227504706

-WWOXchr16

79245505

+
intron-intronENST00000488131ENST00000569818CDC42BPAchr1

227504706

-WWOXchr16

79245505

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366767CDC42BPAchr1227504706-ENST00000539474WWOXchr1679245505+12381780704234
ENST00000366769CDC42BPAchr1227504706-ENST00000539474WWOXchr1679245505+2530147012921996234
ENST00000366764CDC42BPAchr1227504706-ENST00000539474WWOXchr1679245505+218111219431647234
ENST00000334218CDC42BPAchr1227504706-ENST00000539474WWOXchr1679245505+218111219431647234
ENST00000366766CDC42BPAchr1227504706-ENST00000539474WWOXchr1679245505+218111219431647234
ENST00000535525CDC42BPAchr1227504706-ENST00000539474WWOXchr1679245505+126520527731234
ENST00000366765CDC42BPAchr1227504706-ENST00000539474WWOXchr1679245505+17707105321236234

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366767ENST00000539474CDC42BPAchr1227504706-WWOXchr1679245505+0.210489840.7895102
ENST00000366769ENST00000539474CDC42BPAchr1227504706-WWOXchr1679245505+0.199490370.8005097
ENST00000366764ENST00000539474CDC42BPAchr1227504706-WWOXchr1679245505+0.135172350.8648276
ENST00000334218ENST00000539474CDC42BPAchr1227504706-WWOXchr1679245505+0.135172350.8648276
ENST00000366766ENST00000539474CDC42BPAchr1227504706-WWOXchr1679245505+0.135172350.8648276
ENST00000535525ENST00000539474CDC42BPAchr1227504706-WWOXchr1679245505+0.222793950.77720606
ENST00000366765ENST00000539474CDC42BPAchr1227504706-WWOXchr1679245505+0.093328270.9066717

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Fusion Genomic Features for CDC42BPA-WWOX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDC42BPAchr1227504705-WWOXchr1679245504+7.75E-050.9999225
CDC42BPAchr1227504705-WWOXchr1679245504+7.75E-050.9999225

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CDC42BPA-WWOX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:227504706/chr16:79245505)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWWOXchr1:227504706chr16:79245505ENST000003558600616_490190.0DomainWW 1
TgeneWWOXchr1:227504706chr16:79245505ENST000003558600657_900190.0DomainWW 2
TgeneWWOXchr1:227504706chr16:79245505ENST0000040898401016_490311.6666666666667DomainWW 1
TgeneWWOXchr1:227504706chr16:79245505ENST0000040898401057_900311.6666666666667DomainWW 2
TgeneWWOXchr1:227504706chr16:79245505ENST000005698180116_49037.0DomainWW 1
TgeneWWOXchr1:227504706chr16:79245505ENST000005698180157_90037.0DomainWW 2
TgeneWWOXchr1:227504706chr16:79245505ENST000003558600650_550190.0MotifNuclear localization signal
TgeneWWOXchr1:227504706chr16:79245505ENST0000040898401050_550311.6666666666667MotifNuclear localization signal
TgeneWWOXchr1:227504706chr16:79245505ENST000005698180150_55037.0MotifNuclear localization signal
TgeneWWOXchr1:227504706chr16:79245505ENST0000035586006131_1370190.0Nucleotide bindingNADP
TgeneWWOXchr1:227504706chr16:79245505ENST00000408984010131_1370311.6666666666667Nucleotide bindingNADP
TgeneWWOXchr1:227504706chr16:79245505ENST0000056981801131_137037.0Nucleotide bindingNADP
TgeneWWOXchr1:227504706chr16:79245505ENST0000035586006209_2730190.0RegionMediates targeting to the mitochondria
TgeneWWOXchr1:227504706chr16:79245505ENST0000040265535209_273136312.0RegionMediates targeting to the mitochondria
TgeneWWOXchr1:227504706chr16:79245505ENST0000040688446209_273172235.0RegionMediates targeting to the mitochondria
TgeneWWOXchr1:227504706chr16:79245505ENST00000408984010209_2730311.6666666666667RegionMediates targeting to the mitochondria
TgeneWWOXchr1:227504706chr16:79245505ENST0000056981801209_273037.0RegionMediates targeting to the mitochondria

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000334218-137437_820591782.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000334218-137880_943591782.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366764-135437_820591692.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366764-135880_943591692.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366765-137437_820591733.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366765-137880_943591733.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366766-137437_820591755.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366766-137880_943591755.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366767-135437_820591639.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366767-135880_943591639.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366769-136437_820591720.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366769-136880_943591720.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000334218-1371082_1201591782.0DomainPH
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000334218-1371227_1499591782.0DomainCNH
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000334218-1371571_1584591782.0DomainCRIB
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000334218-137344_414591782.0DomainAGC-kinase C-terminal
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000334218-13777_343591782.0DomainProtein kinase
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366764-1351082_1201591692.0DomainPH
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366764-1351227_1499591692.0DomainCNH
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366764-1351571_1584591692.0DomainCRIB
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366764-135344_414591692.0DomainAGC-kinase C-terminal
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366764-13577_343591692.0DomainProtein kinase
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366765-1371082_1201591733.0DomainPH
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366765-1371227_1499591733.0DomainCNH
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366765-1371571_1584591733.0DomainCRIB
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366765-137344_414591733.0DomainAGC-kinase C-terminal
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366765-13777_343591733.0DomainProtein kinase
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366766-1371082_1201591755.0DomainPH
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366766-1371227_1499591755.0DomainCNH
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366766-1371571_1584591755.0DomainCRIB
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366766-137344_414591755.0DomainAGC-kinase C-terminal
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366766-13777_343591755.0DomainProtein kinase
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366767-1351082_1201591639.0DomainPH
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366767-1351227_1499591639.0DomainCNH
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366767-1351571_1584591639.0DomainCRIB
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366767-135344_414591639.0DomainAGC-kinase C-terminal
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366767-13577_343591639.0DomainProtein kinase
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366769-1361082_1201591720.0DomainPH
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366769-1361227_1499591720.0DomainCNH
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366769-1361571_1584591720.0DomainCRIB
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366769-136344_414591720.0DomainAGC-kinase C-terminal
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366769-13677_343591720.0DomainProtein kinase
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000334218-13783_91591782.0Nucleotide bindingATP
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366764-13583_91591692.0Nucleotide bindingATP
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366765-13783_91591733.0Nucleotide bindingATP
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366766-13783_91591755.0Nucleotide bindingATP
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366767-13583_91591639.0Nucleotide bindingATP
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366769-13683_91591720.0Nucleotide bindingATP
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000334218-1371012_1062591782.0Zinc fingerPhorbol-ester/DAG-type
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366764-1351012_1062591692.0Zinc fingerPhorbol-ester/DAG-type
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366765-1371012_1062591733.0Zinc fingerPhorbol-ester/DAG-type
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366766-1371012_1062591755.0Zinc fingerPhorbol-ester/DAG-type
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366767-1351012_1062591639.0Zinc fingerPhorbol-ester/DAG-type
HgeneCDC42BPAchr1:227504706chr16:79245505ENST00000366769-1361012_1062591720.0Zinc fingerPhorbol-ester/DAG-type
TgeneWWOXchr1:227504706chr16:79245505ENST000004026553516_49136312.0DomainWW 1
TgeneWWOXchr1:227504706chr16:79245505ENST000004026553557_90136312.0DomainWW 2
TgeneWWOXchr1:227504706chr16:79245505ENST000004068844616_49172235.0DomainWW 1
TgeneWWOXchr1:227504706chr16:79245505ENST000004068844657_90172235.0DomainWW 2
TgeneWWOXchr1:227504706chr16:79245505ENST000005667807916_49352415.0DomainWW 1
TgeneWWOXchr1:227504706chr16:79245505ENST000005667807957_90352415.0DomainWW 2
TgeneWWOXchr1:227504706chr16:79245505ENST000004026553550_55136312.0MotifNuclear localization signal
TgeneWWOXchr1:227504706chr16:79245505ENST000004068844650_55172235.0MotifNuclear localization signal
TgeneWWOXchr1:227504706chr16:79245505ENST000005667807950_55352415.0MotifNuclear localization signal
TgeneWWOXchr1:227504706chr16:79245505ENST0000040265535131_137136312.0Nucleotide bindingNADP
TgeneWWOXchr1:227504706chr16:79245505ENST0000040688446131_137172235.0Nucleotide bindingNADP
TgeneWWOXchr1:227504706chr16:79245505ENST0000056678079131_137352415.0Nucleotide bindingNADP
TgeneWWOXchr1:227504706chr16:79245505ENST0000056678079209_273352415.0RegionMediates targeting to the mitochondria


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Fusion Gene Sequence for CDC42BPA-WWOX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14842_14842_1_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000334218_WWOX_chr16_79245505_ENST00000539474_length(transcript)=2181nt_BP=1121nt
GCGGCCCGGTGCGGGTGTCGGGGAGACCGGGCTCTCTGCCCGGCGCGGCGCGGCGCGGCTCGGCCCACGAGCGACCACCGACATGGAGTG
GGCTCGGGCGGCCAAGTAGCCGCTTCTCCGGAGCCCGGTGCCAGTGCCGCCCGCAGCCCGCCTTCCACCCCCGGCCGCGCCGCCGGTCAG
GCCCTAGGGTGAAGCCGGGAGGAAAATGAAGAGTTTTCACCGGAATCCGTTGAAAATAGGACTGACTGCAAAGCCTTAAAGAAAGAAGGA
CCTCGGGAGGAGAAACGAAAAGCCGCCTCCGGGCAAGACTTGGCGTGCTCCGAGCCGAGGGGCTGCTTCAGGGACCTCGCCCCCTCCCTT
TCCCGCTGGAGAAATTGCCGCTGATGCATTATCCAAGTGGTGGTTGGGAGGATTTGCAGCAACATTTTTGGTTTTCCCTCCCCCTTCTAT
GCATTCTGTTTTTTTCCTCCCTTTTCTGTTTTTCTTCTTCCCGGGAAGTGAATTGCTGATGCAAATCGGACTTTATTCATTAATGATGCA
ACCGGATTCGTTTCAGGATTACGTTGCACGAGTTGAATTTTGAATGAAGGAGAAGAGTTTTTTTTTTTTTTTTTAAAGAAGTGTTGACTC
TCTAGTTCGTTGTACTTTTAATTATTATTTTATTTAAATATACGACTTAATTGTATTCTTTTAAAAATGCATTAAGTATATATTTTATGG
TAATTTACCCTCAAAATATATGTATATGGGTGAAATTGAAGACGCTTCAGTTAAGTGAGGTTACTGGTGTGTTGGATGTTTAATTCAGCA
CCAGCATTGCATGACAGTTGTTTGAATAACAAGTGGTTTATTTTTAAAACCATACCTTTTAAAATTTAGGTTCAGATAATAGTAAAAGTC
ATCATAATAATTTAAAGGAAAACCAGCAGAAATCGAAGCAAACATGTCTGGAGAAGTGCGTTTGAGGCAGTTGGAGCAGTTTATTTTGGA
CGGGCCCGCTCAGACCAATGGGCAGTGCTTCAGTGTGGAGACATTACTGGATATACTCATCTGCCTTTATGATGAATGCAATAATTCTCC
ATTGAGAAGAGAGAAGAACATTCTCGAATACCTAGAATGGGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGG
AGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGG
CGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTG
TGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCA
CAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTC
TCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTC
TTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTC
CTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGC
CAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAG
AACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCA
TTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTT
AATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTATGCTTAATA

>14842_14842_1_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000334218_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=234AA_BP=59
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWATGSCHHRVLCCCPRTGGSGRDVLQQLLPLH
ALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWAHTPALCVSPHASARAGPLPNVPPTQIRKSKGNKSSHNRVKNLKYQWEAGN

--------------------------------------------------------------
>14842_14842_2_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000366764_WWOX_chr16_79245505_ENST00000539474_length(transcript)=2181nt_BP=1121nt
GCGGCCCGGTGCGGGTGTCGGGGAGACCGGGCTCTCTGCCCGGCGCGGCGCGGCGCGGCTCGGCCCACGAGCGACCACCGACATGGAGTG
GGCTCGGGCGGCCAAGTAGCCGCTTCTCCGGAGCCCGGTGCCAGTGCCGCCCGCAGCCCGCCTTCCACCCCCGGCCGCGCCGCCGGTCAG
GCCCTAGGGTGAAGCCGGGAGGAAAATGAAGAGTTTTCACCGGAATCCGTTGAAAATAGGACTGACTGCAAAGCCTTAAAGAAAGAAGGA
CCTCGGGAGGAGAAACGAAAAGCCGCCTCCGGGCAAGACTTGGCGTGCTCCGAGCCGAGGGGCTGCTTCAGGGACCTCGCCCCCTCCCTT
TCCCGCTGGAGAAATTGCCGCTGATGCATTATCCAAGTGGTGGTTGGGAGGATTTGCAGCAACATTTTTGGTTTTCCCTCCCCCTTCTAT
GCATTCTGTTTTTTTCCTCCCTTTTCTGTTTTTCTTCTTCCCGGGAAGTGAATTGCTGATGCAAATCGGACTTTATTCATTAATGATGCA
ACCGGATTCGTTTCAGGATTACGTTGCACGAGTTGAATTTTGAATGAAGGAGAAGAGTTTTTTTTTTTTTTTTTAAAGAAGTGTTGACTC
TCTAGTTCGTTGTACTTTTAATTATTATTTTATTTAAATATACGACTTAATTGTATTCTTTTAAAAATGCATTAAGTATATATTTTATGG
TAATTTACCCTCAAAATATATGTATATGGGTGAAATTGAAGACGCTTCAGTTAAGTGAGGTTACTGGTGTGTTGGATGTTTAATTCAGCA
CCAGCATTGCATGACAGTTGTTTGAATAACAAGTGGTTTATTTTTAAAACCATACCTTTTAAAATTTAGGTTCAGATAATAGTAAAAGTC
ATCATAATAATTTAAAGGAAAACCAGCAGAAATCGAAGCAAACATGTCTGGAGAAGTGCGTTTGAGGCAGTTGGAGCAGTTTATTTTGGA
CGGGCCCGCTCAGACCAATGGGCAGTGCTTCAGTGTGGAGACATTACTGGATATACTCATCTGCCTTTATGATGAATGCAATAATTCTCC
ATTGAGAAGAGAGAAGAACATTCTCGAATACCTAGAATGGGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGG
AGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGG
CGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTG
TGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCA
CAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTC
TCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTC
TTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTC
CTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGC
CAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAG
AACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCA
TTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTT
AATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTATGCTTAATA

>14842_14842_2_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000366764_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=234AA_BP=59
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWATGSCHHRVLCCCPRTGGSGRDVLQQLLPLH
ALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWAHTPALCVSPHASARAGPLPNVPPTQIRKSKGNKSSHNRVKNLKYQWEAGN

--------------------------------------------------------------
>14842_14842_3_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000366765_WWOX_chr16_79245505_ENST00000539474_length(transcript)=1770nt_BP=710nt
ATTTGCAGCAACATTTTTGGTTTTCCCTCCCCCTTCTATGCATTCTGTTTTTTTCCTCCCTTTTCTGTTTTTCTTCTTCCCGGGAAGTGA
ATTGCTGATGCAAATCGGACTTTATTCATTAATGATGCAACCGGATTCGTTTCAGGATTACGTTGCACGAGTTGAATTTTGAATGAAGGA
GAAGAGTTTTTTTTTTTTTTTTTAAAGAAGTGTTGACTCTCTAGTTCGTTGTACTTTTAATTATTATTTTATTTAAATATACGACTTAAT
TGTATTCTTTTAAAAATGCATTAAGTATATATTTTATGGTAATTTACCCTCAAAATATATGTATATGGGTGAAATTGAAGACGCTTCAGT
TAAGTGAGGTTACTGGTGTGTTGGATGTTTAATTCAGCACCAGCATTGCATGACAGTTGTTTGAATAACAAGTGGTTTATTTTTAAAACC
ATACCTTTTAAAATTTAGGTTCAGATAATAGTAAAAGTCATCATAATAATTTAAAGGAAAACCAGCAGAAATCGAAGCAAACATGTCTGG
AGAAGTGCGTTTGAGGCAGTTGGAGCAGTTTATTTTGGACGGGCCCGCTCAGACCAATGGGCAGTGCTTCAGTGTGGAGACATTACTGGA
TATACTCATCTGCCTTTATGATGAATGCAATAATTCTCCATTGAGAAGAGAGAAGAACATTCTCGAATACCTAGAATGGGCAACAGGGAG
CTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCAC
CAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAG
TGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCC
AACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGG
TAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTG
TAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTA
CCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCC
AGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGT
GAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGC
AAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATA
CACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTA

>14842_14842_3_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000366765_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=234AA_BP=59
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWATGSCHHRVLCCCPRTGGSGRDVLQQLLPLH
ALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWAHTPALCVSPHASARAGPLPNVPPTQIRKSKGNKSSHNRVKNLKYQWEAGN

--------------------------------------------------------------
>14842_14842_4_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000366766_WWOX_chr16_79245505_ENST00000539474_length(transcript)=2181nt_BP=1121nt
GCGGCCCGGTGCGGGTGTCGGGGAGACCGGGCTCTCTGCCCGGCGCGGCGCGGCGCGGCTCGGCCCACGAGCGACCACCGACATGGAGTG
GGCTCGGGCGGCCAAGTAGCCGCTTCTCCGGAGCCCGGTGCCAGTGCCGCCCGCAGCCCGCCTTCCACCCCCGGCCGCGCCGCCGGTCAG
GCCCTAGGGTGAAGCCGGGAGGAAAATGAAGAGTTTTCACCGGAATCCGTTGAAAATAGGACTGACTGCAAAGCCTTAAAGAAAGAAGGA
CCTCGGGAGGAGAAACGAAAAGCCGCCTCCGGGCAAGACTTGGCGTGCTCCGAGCCGAGGGGCTGCTTCAGGGACCTCGCCCCCTCCCTT
TCCCGCTGGAGAAATTGCCGCTGATGCATTATCCAAGTGGTGGTTGGGAGGATTTGCAGCAACATTTTTGGTTTTCCCTCCCCCTTCTAT
GCATTCTGTTTTTTTCCTCCCTTTTCTGTTTTTCTTCTTCCCGGGAAGTGAATTGCTGATGCAAATCGGACTTTATTCATTAATGATGCA
ACCGGATTCGTTTCAGGATTACGTTGCACGAGTTGAATTTTGAATGAAGGAGAAGAGTTTTTTTTTTTTTTTTTAAAGAAGTGTTGACTC
TCTAGTTCGTTGTACTTTTAATTATTATTTTATTTAAATATACGACTTAATTGTATTCTTTTAAAAATGCATTAAGTATATATTTTATGG
TAATTTACCCTCAAAATATATGTATATGGGTGAAATTGAAGACGCTTCAGTTAAGTGAGGTTACTGGTGTGTTGGATGTTTAATTCAGCA
CCAGCATTGCATGACAGTTGTTTGAATAACAAGTGGTTTATTTTTAAAACCATACCTTTTAAAATTTAGGTTCAGATAATAGTAAAAGTC
ATCATAATAATTTAAAGGAAAACCAGCAGAAATCGAAGCAAACATGTCTGGAGAAGTGCGTTTGAGGCAGTTGGAGCAGTTTATTTTGGA
CGGGCCCGCTCAGACCAATGGGCAGTGCTTCAGTGTGGAGACATTACTGGATATACTCATCTGCCTTTATGATGAATGCAATAATTCTCC
ATTGAGAAGAGAGAAGAACATTCTCGAATACCTAGAATGGGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGG
AGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGG
CGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTG
TGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCA
CAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTC
TCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTC
TTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTC
CTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGC
CAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAG
AACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCA
TTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTT
AATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTATGCTTAATA

>14842_14842_4_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000366766_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=234AA_BP=59
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWATGSCHHRVLCCCPRTGGSGRDVLQQLLPLH
ALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWAHTPALCVSPHASARAGPLPNVPPTQIRKSKGNKSSHNRVKNLKYQWEAGN

--------------------------------------------------------------
>14842_14842_5_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000366767_WWOX_chr16_79245505_ENST00000539474_length(transcript)=1238nt_BP=178nt
ATGTCTGGAGAAGTGCGTTTGAGGCAGTTGGAGCAGTTTATTTTGGACGGGCCCGCTCAGACCAATGGGCAGTGCTTCAGTGTGGAGACA
TTACTGGATATACTCATCTGCCTTTATGATGAATGCAATAATTCTCCATTGAGAAGAGAGAAGAACATTCTCGAATACCTAGAATGGGCA
ACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCAT
GCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTC
CGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAAT
GTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAAT
TCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGC
TTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCA
TCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGC
ATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCC
CAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAA
TGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACT
TAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTC

>14842_14842_5_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000366767_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=234AA_BP=59
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWATGSCHHRVLCCCPRTGGSGRDVLQQLLPLH
ALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWAHTPALCVSPHASARAGPLPNVPPTQIRKSKGNKSSHNRVKNLKYQWEAGN

--------------------------------------------------------------
>14842_14842_6_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000366769_WWOX_chr16_79245505_ENST00000539474_length(transcript)=2530nt_BP=1470nt
TCCGCAAGCCTCCGCCTCTGTGCGGCGGGACTGGAGGAGCCTCGCTGAGCCCAGGGCGCGAGCGCGAGAGGAGAGGGAAGGCGGGGGAGG
GCTGGAAGGGAGAGGAAGGGAGTGGTTGGGAGCCGGGCTGCCGCAGCCTCTAGTCTCCTCAGCCGCGGAAGCGACCCCTCCTCCTGCGCC
GGGCCGCCTCCCTCCTCGCTGTGGAAAGATGCCCTTAGCCCAGGGGTGTGAAGAAGGGGGAGAAGTAGCTGCCAGAGCCGCCCGCGCCGC
CGCCGCAGCTGCTGCTGCTTGTGTCCTTTGAATTCAGAGAAGCACCCCCCCGCCTGGGGCGTCGGGAGCCTCCGGCGCGGCGGCCCGGTG
CGGGTGTCGGGGAGACCGGGCTCTCTGCCCGGCGCGGCGCGGCGCGGCTCGGCCCACGAGCGACCACCGACATGGAGTGGGCTCGGGCGG
CCAAGTAGCCGCTTCTCCGGAGCCCGGTGCCAGTGCCGCCCGCAGCCCGCCTTCCACCCCCGGCCGCGCCGCCGGTCAGGCCCTAGGGTG
AAGCCGGGAGGAAAATGAAGAGTTTTCACCGGAATCCGTTGAAAATAGGACTGACTGCAAAGCCTTAAAGAAAGAAGGACCTCGGGAGGA
GAAACGAAAAGCCGCCTCCGGGCAAGACTTGGCGTGCTCCGAGCCGAGGGGCTGCTTCAGGGACCTCGCCCCCTCCCTTTCCCGCTGGAG
AAATTGCCGCTGATGCATTATCCAAGTGGTGGTTGGGAGGATTTGCAGCAACATTTTTGGTTTTCCCTCCCCCTTCTATGCATTCTGTTT
TTTTCCTCCCTTTTCTGTTTTTCTTCTTCCCGGGAAGTGAATTGCTGATGCAAATCGGACTTTATTCATTAATGATGCAACCGGATTCGT
TTCAGGATTACGTTGCACGAGTTGAATTTTGAATGAAGGAGAAGAGTTTTTTTTTTTTTTTTTAAAGAAGTGTTGACTCTCTAGTTCGTT
GTACTTTTAATTATTATTTTATTTAAATATACGACTTAATTGTATTCTTTTAAAAATGCATTAAGTATATATTTTATGGTAATTTACCCT
CAAAATATATGTATATGGGTGAAATTGAAGACGCTTCAGTTAAGTGAGGTTACTGGTGTGTTGGATGTTTAATTCAGCACCAGCATTGCA
TGACAGTTGTTTGAATAACAAGTGGTTTATTTTTAAAACCATACCTTTTAAAATTTAGGTTCAGATAATAGTAAAAGTCATCATAATAAT
TTAAAGGAAAACCAGCAGAAATCGAAGCAAACATGTCTGGAGAAGTGCGTTTGAGGCAGTTGGAGCAGTTTATTTTGGACGGGCCCGCTC
AGACCAATGGGCAGTGCTTCAGTGTGGAGACATTACTGGATATACTCATCTGCCTTTATGATGAATGCAATAATTCTCCATTGAGAAGAG
AGAAGAACATTCTCGAATACCTAGAATGGGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGA
GGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAG
AGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTC
ACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGA
AAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTC
TGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACT
GTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGA
AGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAA
CTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGT
GGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATA
CCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGT
CTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTATGCTTAATAAAAGAACATGC

>14842_14842_6_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000366769_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=234AA_BP=59
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWATGSCHHRVLCCCPRTGGSGRDVLQQLLPLH
ALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWAHTPALCVSPHASARAGPLPNVPPTQIRKSKGNKSSHNRVKNLKYQWEAGN

--------------------------------------------------------------
>14842_14842_7_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000535525_WWOX_chr16_79245505_ENST00000539474_length(transcript)=1265nt_BP=205nt
GGAAAACCAGCAGAAATCGAAGCAAACATGTCTGGAGAAGTGCGTTTGAGGCAGTTGGAGCAGTTTATTTTGGACGGGCCCGCTCAGACC
AATGGGCAGTGCTTCAGTGTGGAGACATTACTGGATATACTCATCTGCCTTTATGATGAATGCAATAATTCTCCATTGAGAAGAGAGAAG
AACATTCTCGAATACCTAGAATGGGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGAT
GTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCT
GATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCA
AGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAAT
CTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTG
GTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTAT
AGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAA
AAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCT
GGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAA
AGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTG
AAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTC
AATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTATGCTTAATAAAAGAACATGCTTGAA

>14842_14842_7_CDC42BPA-WWOX_CDC42BPA_chr1_227504706_ENST00000535525_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=234AA_BP=59
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWATGSCHHRVLCCCPRTGGSGRDVLQQLLPLH
ALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWAHTPALCVSPHASARAGPLPNVPPTQIRKSKGNKSSHNRVKNLKYQWEAGN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDC42BPA-WWOX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneWWOXchr1:227504706chr16:79245505ENST0000035586006125_4140190.0MAPT
TgeneWWOXchr1:227504706chr16:79245505ENST00000408984010125_4140311.6666666666667MAPT
TgeneWWOXchr1:227504706chr16:79245505ENST0000056981801125_414037.0MAPT


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneWWOXchr1:227504706chr16:79245505ENST0000040265535125_414136.33333333333334312.0MAPT
TgeneWWOXchr1:227504706chr16:79245505ENST0000040688446125_414172.0235.0MAPT
TgeneWWOXchr1:227504706chr16:79245505ENST0000056678079125_414352.0415.0MAPT


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDC42BPA-WWOX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDC42BPA-WWOX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0279626Squamous cell carcinoma of esophagus3CTD_human;ORPHANET
TgeneC3280452SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 122GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC4015519EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 282CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0002395Alzheimer's Disease1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007137Squamous cell carcinoma1CTD_human
TgeneC0011265Presenile dementia1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0042076Urologic Neoplasms1CTD_human
TgeneC0087031Juvenile-Onset Still Disease1CTD_human
TgeneC0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneC0494463Alzheimer Disease, Late Onset1CTD_human
TgeneC0546126Acute Confusional Senile Dementia1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneC0751571Cancer of Urinary Tract1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC3495559Juvenile arthritis1CTD_human
TgeneC3714758Juvenile psoriatic arthritis1CTD_human
TgeneC451074446,XY partial gonadal dysgenesis1ORPHANET
TgeneC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human