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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ABHD14B-POC1A (FusionGDB2 ID:HG84836TG25886)

Fusion Gene Summary for ABHD14B-POC1A

Fusion gene summary

Fusion gene information	Fusion gene name: ABHD14B-POC1A
	Fusion gene ID: hg84836tg25886
		Hgene	Tgene
	Gene symbol	ABHD14B	POC1A
	Gene ID	84836	25886
	Gene name	abhydrolase domain containing 14B	POC1 centriolar protein A
	Synonyms	CIB\|HEL-S-299	PIX2\|SOFT\|WDR51A
	Cytomap	('ABHD14B')('POC1A') 3p21.2	3p21.2
	Type of gene	protein-coding	protein-coding
	Description	protein ABHD14BCCG1-interacting factor Babhydrolase domain-containing protein 14Balpha/beta hydrolase domain-containing protein 14Bcell cycle gene 1-interacting factor Bepididymis secretory protein Li 299epididymis secretory sperm binding protein	POC1 centriolar protein homolog AWD repeat domain 51AWD repeat-containing protein 51Aproteome of centriole protein 1A
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000315877, ENST00000361143, ENST00000395008, ENST00000461108, ENST00000483233, ENST00000487005, ENST00000525795,
Fusion gene scores	* DoF score	6 X 6 X 5=180	5 X 4 X 5=100
	# samples	8	7
	** MAII score	log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ABHD14B [Title/Abstract] AND POC1A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ABHD14B(52007981)-POC1A(52130728), # samples:2
Anticipated loss of major functional domain due to fusion event.	ABHD14B-POC1A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABHD14B	GO:0045944	positive regulation of transcription by RNA polymerase II	14672934

Fusion gene breakpoints across ABHD14B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across POC1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A1F0-01A	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
ChimerDB4	BRCA	TCGA-BH-A1F0	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
ChimerDB4	UCS	TCGA-NA-A4R0-01A	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
ChimerDB4	UCS	TCGA-NA-A4RO	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-

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Fusion Gene ORF analysis for ABHD14B-POC1A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000315877	ENST00000296484	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000315877	ENST00000296484	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-3CDS	ENST00000315877	ENST00000394970	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000315877	ENST00000474012	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000361143	ENST00000296484	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000361143	ENST00000296484	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-3CDS	ENST00000361143	ENST00000394970	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000361143	ENST00000474012	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000395008	ENST00000296484	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000395008	ENST00000296484	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-3CDS	ENST00000395008	ENST00000394970	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000395008	ENST00000474012	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000461108	ENST00000296484	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000461108	ENST00000296484	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-3CDS	ENST00000461108	ENST00000394970	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000461108	ENST00000474012	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000483233	ENST00000296484	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000483233	ENST00000296484	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-3CDS	ENST00000483233	ENST00000394970	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000483233	ENST00000474012	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000487005	ENST00000296484	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000487005	ENST00000296484	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-3CDS	ENST00000487005	ENST00000394970	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000487005	ENST00000474012	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000525795	ENST00000296484	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000525795	ENST00000296484	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-3CDS	ENST00000525795	ENST00000394970	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-3CDS	ENST00000525795	ENST00000474012	ABHD14B	chr3	52007980	-	POC1A	chr3	52110001	-
5UTR-intron	ENST00000315877	ENST00000394970	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-intron	ENST00000315877	ENST00000474012	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-intron	ENST00000361143	ENST00000394970	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-intron	ENST00000361143	ENST00000474012	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-intron	ENST00000395008	ENST00000394970	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-intron	ENST00000395008	ENST00000474012	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-intron	ENST00000461108	ENST00000394970	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-intron	ENST00000461108	ENST00000474012	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-intron	ENST00000483233	ENST00000394970	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-intron	ENST00000483233	ENST00000474012	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-intron	ENST00000487005	ENST00000394970	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-intron	ENST00000487005	ENST00000474012	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-intron	ENST00000525795	ENST00000394970	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
5UTR-intron	ENST00000525795	ENST00000474012	ABHD14B	chr3	52007981	-	POC1A	chr3	52130728	-
Frame-shift	ENST00000315877	ENST00000296484	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
Frame-shift	ENST00000315877	ENST00000474012	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
Frame-shift	ENST00000361143	ENST00000296484	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
Frame-shift	ENST00000361143	ENST00000474012	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
Frame-shift	ENST00000395008	ENST00000394970	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
Frame-shift	ENST00000395008	ENST00000474012	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
Frame-shift	ENST00000461108	ENST00000296484	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
Frame-shift	ENST00000461108	ENST00000474012	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
Frame-shift	ENST00000483233	ENST00000296484	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
Frame-shift	ENST00000483233	ENST00000394970	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
Frame-shift	ENST00000525795	ENST00000296484	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
Frame-shift	ENST00000525795	ENST00000474012	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
In-frame	ENST00000315877	ENST00000394970	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
In-frame	ENST00000361143	ENST00000394970	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
In-frame	ENST00000395008	ENST00000296484	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
In-frame	ENST00000461108	ENST00000394970	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
In-frame	ENST00000483233	ENST00000474012	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
In-frame	ENST00000525795	ENST00000394970	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
intron-3CDS	ENST00000487005	ENST00000296484	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
intron-3CDS	ENST00000487005	ENST00000394970	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-
intron-3CDS	ENST00000487005	ENST00000474012	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000483233	ABHD14B	chr3	52005476	-	ENST00000474012	POC1A	chr3	52110001	-	1250	718	321	896	191
ENST00000315877	ABHD14B	chr3	52005476	-	ENST00000394970	POC1A	chr3	52110001	-	1605	905	508	1083	191
ENST00000395008	ABHD14B	chr3	52005476	-	ENST00000296484	POC1A	chr3	52110001	-	1233	500	648	127	173
ENST00000361143	ABHD14B	chr3	52005476	-	ENST00000394970	POC1A	chr3	52110001	-	1041	341	1	519	172
ENST00000461108	ABHD14B	chr3	52005476	-	ENST00000394970	POC1A	chr3	52110001	-	996	296	31	474	147
ENST00000525795	ABHD14B	chr3	52005476	-	ENST00000394970	POC1A	chr3	52110001	-	1105	405	553	107	148

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000483233	ENST00000474012	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-	0.10813661	0.89186335
ENST00000315877	ENST00000394970	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-	0.12280584	0.87719417
ENST00000395008	ENST00000296484	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-	0.047147132	0.9528529
ENST00000361143	ENST00000394970	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-	0.1501599	0.84984004
ENST00000461108	ENST00000394970	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-	0.05033126	0.9496687
ENST00000525795	ENST00000394970	ABHD14B	chr3	52005476	-	POC1A	chr3	52110001	-	0.060856387	0.9391436

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Fusion Genomic Features for ABHD14B-POC1A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for ABHD14B-POC1A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52007981/chr3:52130728)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000394970

369_397

327

360.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000474012

369_397

337

370.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000296484

369_397

375

408.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000296484

101_140

375

408.0

Repeat

Note=WD 3

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000296484

143_182

375

408.0

Repeat

Note=WD 4

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000296484

17_56

375

408.0

Repeat

Note=WD 1

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000296484

185_224

375

408.0

Repeat

Note=WD 5

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000296484

227_266

375

408.0

Repeat

Note=WD 6

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000296484

269_308

375

408.0

Repeat

Note=WD 7

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000296484

59_98

375

408.0

Repeat

Note=WD 2

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000394970

101_140

327

360.0

Repeat

Note=WD 3

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000394970

143_182

327

360.0

Repeat

Note=WD 4

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000394970

17_56

327

360.0

Repeat

Note=WD 1

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000394970

185_224

327

360.0

Repeat

Note=WD 5

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000394970

227_266

327

360.0

Repeat

Note=WD 6

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000394970

269_308

327

360.0

Repeat

Note=WD 7

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000394970

59_98

327

360.0

Repeat

Note=WD 2

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000474012

101_140

337

370.0

Repeat

Note=WD 3

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000474012

143_182

337

370.0

Repeat

Note=WD 4

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000474012

17_56

337

370.0

Repeat

Note=WD 1

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000474012

185_224

337

370.0

Repeat

Note=WD 5

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000474012

227_266

337

370.0

Repeat

Note=WD 6

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000474012

269_308

337

370.0

Repeat

Note=WD 7

Tgene

POC1A

chr3:52005476

chr3:52110001

ENST00000474012

59_98

337

370.0

Repeat

Note=WD 2

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Fusion Gene Sequence for ABHD14B-POC1A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>389_389_1_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000315877_POC1A_chr3_52110001_ENST00000394970_length(transcript)=1605nt_BP=905nt
CTACTCATGGCGCCTGCCCTGGTTGGCGATGTGTTACCAACGTCTGGCCTGTCCCAGCCCAAGGCTCCGCGTGGCGACCAGGCCCAGCAC
TGGGAGGCTGTGCAGAGCGTGGCGTTTACTGCTTATTGCTACTCTGCAGAGGTTGGCAACATCTGACCCGCTCTACTGGCAGGAAACAGG
CTCGGGGGCATTGGGAAAACGATCAAGGCCACTTGGCTGGACACTGGCGGAGCCTCGCACTCAAACCTGTCGGGCCTCAACTCCGTGCCA
GGCCAACAAGTTGCCCTGGGCAGTTCAAGCTGGGGATAAGGGGGATGGGGAGCAGGAAGACAGCAGCAAGGATGCGATCCCGAAGGAACT
TTCCTCCTCAGACTGCTCCATGTCCATGTGGGGCAGGTCGCTGAAGAGTTCGAAACCGTGCTCAGCACCGCGTTTGGGGCATGTGAGACC
GAGAGGCTTTGGGAAACTGACGCCGCTGTGAGAACGAGTTTAGCGGAGTCTATGGACGCTGCGAGCTTGTGGCCACAAGAGGGCGCCCCG
GAGCACGGCCCAGTCCCCGCCCCCGCTGGATGGGGCCCGGCCTCTTCCCAGCGTTCCTCCTCCGGCCCCAGGTCACCGCCAGCACGCGCC
TGCTTCCCGTCTGCGCGAGTCCACGCAGCTCCCCAGGCCCTTCACCAGCACAGCAGCAGCAGGCATGGCAGCAAGCGTGGAGCAGCGCGA
GGGCACCATCCAGGTGCAGGGCCAGGCCCTCTTCTTCCGAGAGGCCCTGCCCGGCAGTGGGCAGGCTCGCTTCTCTGTACTGCTGCTGCA
TGGTATTCGCTTCTCCTCCGAGACCTGGCAGAACCTGGGTACACTGCACAGGCTGGCCCAGGCTGGCTACCGGGCTGTGGCCATTGACCT
GCCAGACAGTCTCCATTCTGGAGCAGCGGTTGACACTGACAGAAGACAAGCTGAAGCAGTGTCTGGAGAACCAGCAGCTAATCATGCAGA
GAGCAACACCATGATCAGGGGAGCAGGAATCAGGAGCTCGGTGGATTTGCAGGTGGCAGGCCAGGGATTTGTACCATGGGACTTGGGTAA
ATAAAGGGGACTGAACTCTGTGGGAATCACATCCATACTGGAGCCCTGGATTTTTGCAGTTCTGCCCTCCACCTTGCTATCTGCACCAGG
AGGCTCTCCACCTGGCAGCCAGAGGTCCCCAGTGGGCCGGGCTCACACACAAATGATGCTTCAGACCCGAATGAGAGGACCACATTTTGC
TTAATGTAAAGGAGCCACTTGAAAATGTCTGCTCCTTCGGGGTCCTGAGATTGTGGCTCCCCCTCTGGAGGAGGTGGCTCCACGATGCCT
TGATTTTCACTCATCATTTGGACATGTGACTGGCTTTTCCTACCTCTGCCATGGTGTAGAAATTGATTGCACATTGATTGGATGAGCCGG
GGGTTTTCTCTAAATCTGACTAAAGGCCCAAAGTGGGCCCATCTGAGTCAGGTTTGTTGAGAACAAGCCCTCTCAAGTGGGTGGTGGCTT
TTCAGTGGCCCTGATTTCTGTTCCACACGTGTTCACTGGAGCCAGGTGACTTCCTCCTTGCGTGAGTGAGGGCAC

>389_389_1_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000315877_POC1A_chr3_52110001_ENST00000394970_length(amino acids)=191AA_BP=132
MRACGHKRAPRSTAQSPPPLDGARPLPSVPPPAPGHRQHAPASRLRESTQLPRPFTSTAAAGMAASVEQREGTIQVQGQALFFREALPGS
GQARFSVLLLHGIRFSSETWQNLGTLHRLAQAGYRAVAIDLPDSLHSGAAVDTDRRQAEAVSGEPAANHAESNTMIRGAGIRSSVDLQVA
GQGFVPWDLGK

--------------------------------------------------------------
>389_389_2_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000361143_POC1A_chr3_52110001_ENST00000394970_length(transcript)=1041nt_BP=341nt
GCTGGATGGGGCCCGGCCTCTTCCCAGCGTTCCTCCTCCGGCCCCAGGTCACCGCCAGCACGCGCCTGCTTCCCGTCTGCGCGAGTCCAC
GCAGCTCCCCAGGCCCTTCACCAGCACAGCAGCAGCAGGCATGGCAGCAAGCGTGGAGCAGCGCGAGGGCACCATCCAGGTGCAGGGCCA
GGCCCTCTTCTTCCGAGAGGCCCTGCCCGGCAGTGGGCAGGCTCGCTTCTCTGTACTGCTGCTGCATGGTATTCGCTTCTCCTCCGAGAC
CTGGCAGAACCTGGGTACACTGCACAGGCTGGCCCAGGCTGGCTACCGGGCTGTGGCCATTGACCTGCCAGACAGTCTCCATTCTGGAGC
AGCGGTTGACACTGACAGAAGACAAGCTGAAGCAGTGTCTGGAGAACCAGCAGCTAATCATGCAGAGAGCAACACCATGATCAGGGGAGC
AGGAATCAGGAGCTCGGTGGATTTGCAGGTGGCAGGCCAGGGATTTGTACCATGGGACTTGGGTAAATAAAGGGGACTGAACTCTGTGGG
AATCACATCCATACTGGAGCCCTGGATTTTTGCAGTTCTGCCCTCCACCTTGCTATCTGCACCAGGAGGCTCTCCACCTGGCAGCCAGAG
GTCCCCAGTGGGCCGGGCTCACACACAAATGATGCTTCAGACCCGAATGAGAGGACCACATTTTGCTTAATGTAAAGGAGCCACTTGAAA
ATGTCTGCTCCTTCGGGGTCCTGAGATTGTGGCTCCCCCTCTGGAGGAGGTGGCTCCACGATGCCTTGATTTTCACTCATCATTTGGACA
TGTGACTGGCTTTTCCTACCTCTGCCATGGTGTAGAAATTGATTGCACATTGATTGGATGAGCCGGGGGTTTTCTCTAAATCTGACTAAA
GGCCCAAAGTGGGCCCATCTGAGTCAGGTTTGTTGAGAACAAGCCCTCTCAAGTGGGTGGTGGCTTTTCAGTGGCCCTGATTTCTGTTCC
ACACGTGTTCACTGGAGCCAGGTGACTTCCTCCTTGCGTGAGTGAGGGCAC

>389_389_2_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000361143_POC1A_chr3_52110001_ENST00000394970_length(amino acids)=172AA_BP=113
LDGARPLPSVPPPAPGHRQHAPASRLRESTQLPRPFTSTAAAGMAASVEQREGTIQVQGQALFFREALPGSGQARFSVLLLHGIRFSSET
WQNLGTLHRLAQAGYRAVAIDLPDSLHSGAAVDTDRRQAEAVSGEPAANHAESNTMIRGAGIRSSVDLQVAGQGFVPWDLGK

--------------------------------------------------------------
>389_389_3_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000395008_POC1A_chr3_52110001_ENST00000296484_length(transcript)=1233nt_BP=500nt
CTCCGGCCCCAGGTCACCGCCAGCACGCGCCTGCTTCCCGTCTGCGCGAGTCCACGCAGCTCCCCAGATCAAGAAGCTGAGGCCCCAGGT
TACACACTAAAGTAAATGGCAGAGGCAGAAATAACACCTATGTCCTCCTGACCCCAAGGCATGTTCTTAAAGTTCTGGAAACCTCCTGGA
GGCTTCCTTGCTGCTCCTCTGGGACTGCCACCCTGGGCAGGGTGTTCTGTGGCCCCTCATCATCGTGGTTTTGAACCACAGGCCCTTCAC
CAGCACAGCAGCAGCAGGCATGGCAGCAAGCGTGGAGCAGCGCGAGGGCACCATCCAGGTGCAGGGCCAGGCCCTCTTCTTCCGAGAGGC
CCTGCCCGGCAGTGGGCAGGCTCGCTTCTCTGTACTGCTGCTGCATGGTATTCGCTTCTCCTCCGAGACCTGGCAGAACCTGGGTACACT
GCACAGGCTGGCCCAGGCTGGCTACCGGGCTGTGGCCATTGACCTGCCAGACAGTCTCCATTCTGGAGCAGCGGTTGACACTGACAGAAG
ACAAGCTGAAGCAGTGTCTGGAGAACCAGCAGCTAATCATGCAGAGAGCAACACCATGATCAGGGGAGCAGGAATCAGGAGCTCGGTGGA
TTTGCAGGTGGCAGGCCAGGGATTTGTACCATGGGACTTGGGTAAATAAAGGGGACTGAACTCTGTGGGAATCACATCCATACTGGAGCC
CTGGATTTTTGCAGTTCTGCCCTCCACCTTGCTATCTGCACCAGGAGGCTCTCCACCTGGCAGCCAGAGGTCCCCAGTGGGCCGGGCTCA
CACACAAATGATGCTTCAGACCCGAATGAGAGGACCACATTTTGCTTAATGTAAAGGAGCCACTTGAAAATGTCTGCTCCTTCGGGGTCC
TGAGATTGTGGCTCCCCCTCTGGAGGAGGTGGCTCCACGATGCCTTGATTTTCACTCATCATTTGGACATGTGACTGGCTTTTCCTACCT
CTGCCATGGTGTAGAAATTGATTGCACATTGATTGGATGAGCCGGGGGTTTTCTCTAAATCTGACTAAAGGCCCAAAGTGGGCCCATCTG
AGTCAGGTTTGTTGAGAACAAGCCCTCTCAAGTGGGTGGTGGCTTTTCAGTGGCCCTGATTTCTGTTCCACACGTGTTCACTGGAGCCAG
GTGACTTCCTCCTTGCGTGAGTGAGGGCACAGGAATCTCAAAATTAAACCTGACTTCATTGCA

>389_389_3_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000395008_POC1A_chr3_52110001_ENST00000296484_length(amino acids)=173AA_BP=1
MACHLQIHRAPDSCSPDHGVALCMISCWFSRHCFSLSSVSVNRCSRMETVWQVNGHSPVASLGQPVQCTQVLPGLGGEANTMQQQYREAS
LPTAGQGLSEEEGLALHLDGALALLHACCHACCCCAGEGPVVQNHDDEGPQNTLPRVAVPEEQQGSLQEVSRTLRTCLGVRRT

--------------------------------------------------------------
>389_389_4_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000461108_POC1A_chr3_52110001_ENST00000394970_length(transcript)=996nt_BP=296nt
AGGTCACCGCCAGCACGCGCCTGCTTCCCGTCTGCGCGAGTCCACGCAGCTCCCCAGGCCCTTCACCAGCACAGCAGCAGCAGGCATGGC
AGCAAGCGTGGAGCAGCGCGAGGGCACCATCCAGGTGCAGGGCCAGGCCCTCTTCTTCCGAGAGGCCCTGCCCGGCAGTGGGCAGGCTCG
CTTCTCTGTACTGCTGCTGCATGGTATTCGCTTCTCCTCCGAGACCTGGCAGAACCTGGGTACACTGCACAGGCTGGCCCAGGCTGGCTA
CCGGGCTGTGGCCATTGACCTGCCAGACAGTCTCCATTCTGGAGCAGCGGTTGACACTGACAGAAGACAAGCTGAAGCAGTGTCTGGAGA
ACCAGCAGCTAATCATGCAGAGAGCAACACCATGATCAGGGGAGCAGGAATCAGGAGCTCGGTGGATTTGCAGGTGGCAGGCCAGGGATT
TGTACCATGGGACTTGGGTAAATAAAGGGGACTGAACTCTGTGGGAATCACATCCATACTGGAGCCCTGGATTTTTGCAGTTCTGCCCTC
CACCTTGCTATCTGCACCAGGAGGCTCTCCACCTGGCAGCCAGAGGTCCCCAGTGGGCCGGGCTCACACACAAATGATGCTTCAGACCCG
AATGAGAGGACCACATTTTGCTTAATGTAAAGGAGCCACTTGAAAATGTCTGCTCCTTCGGGGTCCTGAGATTGTGGCTCCCCCTCTGGA
GGAGGTGGCTCCACGATGCCTTGATTTTCACTCATCATTTGGACATGTGACTGGCTTTTCCTACCTCTGCCATGGTGTAGAAATTGATTG
CACATTGATTGGATGAGCCGGGGGTTTTCTCTAAATCTGACTAAAGGCCCAAAGTGGGCCCATCTGAGTCAGGTTTGTTGAGAACAAGCC
CTCTCAAGTGGGTGGTGGCTTTTCAGTGGCCCTGATTTCTGTTCCACACGTGTTCACTGGAGCCAGGTGACTTCCTCCTTGCGTGAGTGA
GGGCAC

>389_389_4_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000461108_POC1A_chr3_52110001_ENST00000394970_length(amino acids)=147AA_BP=88
MRESTQLPRPFTSTAAAGMAASVEQREGTIQVQGQALFFREALPGSGQARFSVLLLHGIRFSSETWQNLGTLHRLAQAGYRAVAIDLPDS
LHSGAAVDTDRRQAEAVSGEPAANHAESNTMIRGAGIRSSVDLQVAGQGFVPWDLGK

--------------------------------------------------------------
>389_389_5_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000483233_POC1A_chr3_52110001_ENST00000474012_length(transcript)=1250nt_BP=718nt
CCCGGCGCCAGCGGCCGCGTCGGCGCGGATGTCCCCGCCCGCCTCTGGTTCGGGCCTCAGCGAGATTACTGGAGGATTAGATCCGGATCC
CGTCCCCGGGCAGCGGCCGCCGCGGCCAGCGCCGCCCCGCGAGTTGCGAGCTCCGGGCTGGCCCTGCTCTGACAGGCTCGCCCCGCCCCA
CACGACACGCCTGCCACTCCTGCCCCCAGGTCGCTGAAGAGTTCGAAACCGTGCTCAGCACCGCGTTTGGGGCATGTGAGACCGAGAGGC
TTTGGGAAACTGACGCCGCTGTGAGAACGAGTTTAGCGGAGTCTATGGACGCTGCGAGCTTGTGGCCACAAGAGGGCGCCCCGGAGCACG
GCCCAGTCCCCGCCCCCGCTGGATGGGGCCCGGCCTCTTCCCAGCGTTCCTCCTCCGGCCCCAGGTCACCGCCAGCACGCGCCTGCTTCC
CGTCTGCGCGAGTCCACGCAGCTCCCCAGGCCCTTCACCAGCACAGCAGCAGCAGGCATGGCAGCAAGCGTGGAGCAGCGCGAGGGCACC
ATCCAGGTGCAGGGCCAGGCCCTCTTCTTCCGAGAGGCCCTGCCCGGCAGTGGGCAGGCTCGCTTCTCTGTACTGCTGCTGCATGGTATT
CGCTTCTCCTCCGAGACCTGGCAGAACCTGGGTACACTGCACAGGCTGGCCCAGGCTGGCTACCGGGCTGTGGCCATTGACCTGCCAGAC
AGTCTCCATTCTGGAGCAGCGGTTGACACTGACAGAAGACAAGCTGAAGCAGTGTCTGGAGAACCAGCAGCTAATCATGCAGAGAGCAAC
ACCATGATCAGGGGAGCAGGAATCAGGAGCTCGGTGGATTTGCAGGTGGCAGGCCAGGGATTTGTACCATGGGACTTGGGTAAATAAAGG
GGACTGAACTCTGTGGGAATCACATCCATACTGGAGCCCTGGATTTTTGCAGTTCTGCCCTCCACCTTGCTATCTGCACCAGGAGGCTCT
CCACCTGGCAGCCAGAGGTCCCCAGTGGGCCGGGCTCACACACAAATGATGCTTCAGACCCGAATGAGAGGACCACATTTTGCTTAATGT
AAAGGAGCCACTTGAAAATGTCTGCTCCTTCGGGGTCCTGAGATTGTGGCTCCCCCTCTGGAGGAGGTGGCTCCACGATGCCTTGATTTT
CACTCATCATTTGGACATGTGACTGGCTTTTCCTACCTCTGCCATGGTGTAGAAATTGATTGCACATTGATTGGATGAGC

>389_389_5_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000483233_POC1A_chr3_52110001_ENST00000474012_length(amino acids)=191AA_BP=132
MRACGHKRAPRSTAQSPPPLDGARPLPSVPPPAPGHRQHAPASRLRESTQLPRPFTSTAAAGMAASVEQREGTIQVQGQALFFREALPGS
GQARFSVLLLHGIRFSSETWQNLGTLHRLAQAGYRAVAIDLPDSLHSGAAVDTDRRQAEAVSGEPAANHAESNTMIRGAGIRSSVDLQVA
GQGFVPWDLGK

--------------------------------------------------------------
>389_389_6_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000525795_POC1A_chr3_52110001_ENST00000394970_length(transcript)=1105nt_BP=405nt
CTCTTCCCAGCGTTCCTCCTCCGGCCCCAGGTCACCGCCAGCACGCGCCTGCTTCCCGTCTGCGCGAGTCCACGCAGCTCCCCAGATCAA
GAAGCTGAGGCCCCAGGTTACACACTAAAGTAAATGGCAGAGGCAGAAATAACACCTATGTCCTCCTGACCCCAAGGCCCTTCACCAGCA
CAGCAGCAGCAGGCATGGCAGCAAGCGTGGAGCAGCGCGAGGGCACCATCCAGGTGCAGGGCCAGGCCCTCTTCTTCCGAGAGGCCCTGC
CCGGCAGTGGGCAGGCTCGCTTCTCTGTACTGCTGCTGCATGGTATTCGCTTCTCCTCCGAGACCTGGCAGAACCTGGGTACACTGCACA
GGCTGGCCCAGGCTGGCTACCGGGCTGTGGCCATTGACCTGCCAGACAGTCTCCATTCTGGAGCAGCGGTTGACACTGACAGAAGACAAG
CTGAAGCAGTGTCTGGAGAACCAGCAGCTAATCATGCAGAGAGCAACACCATGATCAGGGGAGCAGGAATCAGGAGCTCGGTGGATTTGC
AGGTGGCAGGCCAGGGATTTGTACCATGGGACTTGGGTAAATAAAGGGGACTGAACTCTGTGGGAATCACATCCATACTGGAGCCCTGGA
TTTTTGCAGTTCTGCCCTCCACCTTGCTATCTGCACCAGGAGGCTCTCCACCTGGCAGCCAGAGGTCCCCAGTGGGCCGGGCTCACACAC
AAATGATGCTTCAGACCCGAATGAGAGGACCACATTTTGCTTAATGTAAAGGAGCCACTTGAAAATGTCTGCTCCTTCGGGGTCCTGAGA
TTGTGGCTCCCCCTCTGGAGGAGGTGGCTCCACGATGCCTTGATTTTCACTCATCATTTGGACATGTGACTGGCTTTTCCTACCTCTGCC
ATGGTGTAGAAATTGATTGCACATTGATTGGATGAGCCGGGGGTTTTCTCTAAATCTGACTAAAGGCCCAAAGTGGGCCCATCTGAGTCA
GGTTTGTTGAGAACAAGCCCTCTCAAGTGGGTGGTGGCTTTTCAGTGGCCCTGATTTCTGTTCCACACGTGTTCACTGGAGCCAGGTGAC
TTCCTCCTTGCGTGAGTGAGGGCAC

>389_389_6_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000525795_POC1A_chr3_52110001_ENST00000394970_length(amino acids)=148AA_BP=1
MACHLQIHRAPDSCSPDHGVALCMISCWFSRHCFSLSSVSVNRCSRMETVWQVNGHSPVASLGQPVQCTQVLPGLGGEANTMQQQYREAS
LPTAGQGLSEEEGLALHLDGALALLHACCHACCCCAGEGPWGQEDIGVISASAIYFSV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ABHD14B-POC1A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ABHD14B-POC1A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ABHD14B-POC1A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C3542022	SHORT STATURE, ONYCHODYSPLASIA, FACIAL DYSMORPHISM, AND HYPOTRICHOSIS SYNDROME	5	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0013336	Dwarfism	1	GENOMICS_ENGLAND
Tgene		C0342573	PITUITARY DWARFISM I	1	GENOMICS_ENGLAND
Tgene		C0431350	Primary microcephaly	1	GENOMICS_ENGLAND
Tgene		C3553735	Microcephaly in adulthood	1	GENOMICS_ENGLAND
Tgene		C3808988	FANCONI ANEMIA, COMPLEMENTATION GROUP Q	1	GENOMICS_ENGLAND

Fusion Gene Studies in Kim Lab

Fusion gene:ABHD14B-POC1A (FusionGDB2 ID:HG84836TG25886)

Fusion Gene Summary for ABHD14B-POC1A

Fusion Gene ORF analysis for ABHD14B-POC1A

Fusion Genomic Features for ABHD14B-POC1A

Fusion Protein Features for ABHD14B-POC1A

Fusion Gene Sequence for ABHD14B-POC1A

Fusion Gene PPI Analysis for ABHD14B-POC1A

Related Drugs for ABHD14B-POC1A

Related Diseases for ABHD14B-POC1A

Fusion Gene Studies
in Kim Lab