Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ABHD14B-POC1A (FusionGDB2 ID:HG84836TG25886)

Fusion Gene Summary for ABHD14B-POC1A

check button Fusion gene summary
Fusion gene informationFusion gene name: ABHD14B-POC1A
Fusion gene ID: hg84836tg25886
HgeneTgene
Gene symbol

ABHD14B

POC1A

Gene ID

84836

25886

Gene nameabhydrolase domain containing 14BPOC1 centriolar protein A
SynonymsCIB|HEL-S-299PIX2|SOFT|WDR51A
Cytomap('ABHD14B')('POC1A')

3p21.2

3p21.2

Type of geneprotein-codingprotein-coding
Descriptionprotein ABHD14BCCG1-interacting factor Babhydrolase domain-containing protein 14Balpha/beta hydrolase domain-containing protein 14Bcell cycle gene 1-interacting factor Bepididymis secretory protein Li 299epididymis secretory sperm binding proteinPOC1 centriolar protein homolog AWD repeat domain 51AWD repeat-containing protein 51Aproteome of centriole protein 1A
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000315877, ENST00000361143, 
ENST00000395008, ENST00000461108, 
ENST00000483233, ENST00000487005, 
ENST00000525795, 
Fusion gene scores* DoF score6 X 6 X 5=1805 X 4 X 5=100
# samples 87
** MAII scorelog2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABHD14B [Title/Abstract] AND POC1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABHD14B(52007981)-POC1A(52130728), # samples:2
Anticipated loss of major functional domain due to fusion event.ABHD14B-POC1A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABHD14B

GO:0045944

positive regulation of transcription by RNA polymerase II

14672934


check buttonFusion gene breakpoints across ABHD14B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across POC1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1F0-01AABHD14Bchr3

52005476

-POC1Achr3

52110001

-
ChimerDB4BRCATCGA-BH-A1F0ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
ChimerDB4UCSTCGA-NA-A4R0-01AABHD14Bchr3

52007981

-POC1Achr3

52130728

-
ChimerDB4UCSTCGA-NA-A4ROABHD14Bchr3

52007981

-POC1Achr3

52130728

-


Top

Fusion Gene ORF analysis for ABHD14B-POC1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000315877ENST00000296484ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000315877ENST00000296484ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-3CDSENST00000315877ENST00000394970ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000315877ENST00000474012ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000361143ENST00000296484ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000361143ENST00000296484ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-3CDSENST00000361143ENST00000394970ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000361143ENST00000474012ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000395008ENST00000296484ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000395008ENST00000296484ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-3CDSENST00000395008ENST00000394970ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000395008ENST00000474012ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000461108ENST00000296484ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000461108ENST00000296484ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-3CDSENST00000461108ENST00000394970ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000461108ENST00000474012ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000483233ENST00000296484ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000483233ENST00000296484ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-3CDSENST00000483233ENST00000394970ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000483233ENST00000474012ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000487005ENST00000296484ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000487005ENST00000296484ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-3CDSENST00000487005ENST00000394970ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000487005ENST00000474012ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000525795ENST00000296484ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000525795ENST00000296484ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-3CDSENST00000525795ENST00000394970ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-3CDSENST00000525795ENST00000474012ABHD14Bchr3

52007980

-POC1Achr3

52110001

-
5UTR-intronENST00000315877ENST00000394970ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-intronENST00000315877ENST00000474012ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-intronENST00000361143ENST00000394970ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-intronENST00000361143ENST00000474012ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-intronENST00000395008ENST00000394970ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-intronENST00000395008ENST00000474012ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-intronENST00000461108ENST00000394970ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-intronENST00000461108ENST00000474012ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-intronENST00000483233ENST00000394970ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-intronENST00000483233ENST00000474012ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-intronENST00000487005ENST00000394970ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-intronENST00000487005ENST00000474012ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-intronENST00000525795ENST00000394970ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
5UTR-intronENST00000525795ENST00000474012ABHD14Bchr3

52007981

-POC1Achr3

52130728

-
Frame-shiftENST00000315877ENST00000296484ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
Frame-shiftENST00000315877ENST00000474012ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
Frame-shiftENST00000361143ENST00000296484ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
Frame-shiftENST00000361143ENST00000474012ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
Frame-shiftENST00000395008ENST00000394970ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
Frame-shiftENST00000395008ENST00000474012ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
Frame-shiftENST00000461108ENST00000296484ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
Frame-shiftENST00000461108ENST00000474012ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
Frame-shiftENST00000483233ENST00000296484ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
Frame-shiftENST00000483233ENST00000394970ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
Frame-shiftENST00000525795ENST00000296484ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
Frame-shiftENST00000525795ENST00000474012ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
In-frameENST00000315877ENST00000394970ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
In-frameENST00000361143ENST00000394970ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
In-frameENST00000395008ENST00000296484ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
In-frameENST00000461108ENST00000394970ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
In-frameENST00000483233ENST00000474012ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
In-frameENST00000525795ENST00000394970ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
intron-3CDSENST00000487005ENST00000296484ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
intron-3CDSENST00000487005ENST00000394970ABHD14Bchr3

52005476

-POC1Achr3

52110001

-
intron-3CDSENST00000487005ENST00000474012ABHD14Bchr3

52005476

-POC1Achr3

52110001

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000483233ABHD14Bchr352005476-ENST00000474012POC1Achr352110001-1250718321896191
ENST00000315877ABHD14Bchr352005476-ENST00000394970POC1Achr352110001-16059055081083191
ENST00000395008ABHD14Bchr352005476-ENST00000296484POC1Achr352110001-1233500648127173
ENST00000361143ABHD14Bchr352005476-ENST00000394970POC1Achr352110001-10413411519172
ENST00000461108ABHD14Bchr352005476-ENST00000394970POC1Achr352110001-99629631474147
ENST00000525795ABHD14Bchr352005476-ENST00000394970POC1Achr352110001-1105405553107148

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000483233ENST00000474012ABHD14Bchr352005476-POC1Achr352110001-0.108136610.89186335
ENST00000315877ENST00000394970ABHD14Bchr352005476-POC1Achr352110001-0.122805840.87719417
ENST00000395008ENST00000296484ABHD14Bchr352005476-POC1Achr352110001-0.0471471320.9528529
ENST00000361143ENST00000394970ABHD14Bchr352005476-POC1Achr352110001-0.15015990.84984004
ENST00000461108ENST00000394970ABHD14Bchr352005476-POC1Achr352110001-0.050331260.9496687
ENST00000525795ENST00000394970ABHD14Bchr352005476-POC1Achr352110001-0.0608563870.9391436

Top

Fusion Genomic Features for ABHD14B-POC1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for ABHD14B-POC1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52007981/chr3:52130728)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePOC1Achr3:52005476chr3:52110001ENST00000394970810369_397327360.0Coiled coilOntology_term=ECO:0000255
TgenePOC1Achr3:52005476chr3:52110001ENST00000474012911369_397337370.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePOC1Achr3:52005476chr3:52110001ENST00000296484911369_397375408.0Coiled coilOntology_term=ECO:0000255
TgenePOC1Achr3:52005476chr3:52110001ENST00000296484911101_140375408.0RepeatNote=WD 3
TgenePOC1Achr3:52005476chr3:52110001ENST00000296484911143_182375408.0RepeatNote=WD 4
TgenePOC1Achr3:52005476chr3:52110001ENST0000029648491117_56375408.0RepeatNote=WD 1
TgenePOC1Achr3:52005476chr3:52110001ENST00000296484911185_224375408.0RepeatNote=WD 5
TgenePOC1Achr3:52005476chr3:52110001ENST00000296484911227_266375408.0RepeatNote=WD 6
TgenePOC1Achr3:52005476chr3:52110001ENST00000296484911269_308375408.0RepeatNote=WD 7
TgenePOC1Achr3:52005476chr3:52110001ENST0000029648491159_98375408.0RepeatNote=WD 2
TgenePOC1Achr3:52005476chr3:52110001ENST00000394970810101_140327360.0RepeatNote=WD 3
TgenePOC1Achr3:52005476chr3:52110001ENST00000394970810143_182327360.0RepeatNote=WD 4
TgenePOC1Achr3:52005476chr3:52110001ENST0000039497081017_56327360.0RepeatNote=WD 1
TgenePOC1Achr3:52005476chr3:52110001ENST00000394970810185_224327360.0RepeatNote=WD 5
TgenePOC1Achr3:52005476chr3:52110001ENST00000394970810227_266327360.0RepeatNote=WD 6
TgenePOC1Achr3:52005476chr3:52110001ENST00000394970810269_308327360.0RepeatNote=WD 7
TgenePOC1Achr3:52005476chr3:52110001ENST0000039497081059_98327360.0RepeatNote=WD 2
TgenePOC1Achr3:52005476chr3:52110001ENST00000474012911101_140337370.0RepeatNote=WD 3
TgenePOC1Achr3:52005476chr3:52110001ENST00000474012911143_182337370.0RepeatNote=WD 4
TgenePOC1Achr3:52005476chr3:52110001ENST0000047401291117_56337370.0RepeatNote=WD 1
TgenePOC1Achr3:52005476chr3:52110001ENST00000474012911185_224337370.0RepeatNote=WD 5
TgenePOC1Achr3:52005476chr3:52110001ENST00000474012911227_266337370.0RepeatNote=WD 6
TgenePOC1Achr3:52005476chr3:52110001ENST00000474012911269_308337370.0RepeatNote=WD 7
TgenePOC1Achr3:52005476chr3:52110001ENST0000047401291159_98337370.0RepeatNote=WD 2


Top

Fusion Gene Sequence for ABHD14B-POC1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>389_389_1_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000315877_POC1A_chr3_52110001_ENST00000394970_length(transcript)=1605nt_BP=905nt
CTACTCATGGCGCCTGCCCTGGTTGGCGATGTGTTACCAACGTCTGGCCTGTCCCAGCCCAAGGCTCCGCGTGGCGACCAGGCCCAGCAC
TGGGAGGCTGTGCAGAGCGTGGCGTTTACTGCTTATTGCTACTCTGCAGAGGTTGGCAACATCTGACCCGCTCTACTGGCAGGAAACAGG
CTCGGGGGCATTGGGAAAACGATCAAGGCCACTTGGCTGGACACTGGCGGAGCCTCGCACTCAAACCTGTCGGGCCTCAACTCCGTGCCA
GGCCAACAAGTTGCCCTGGGCAGTTCAAGCTGGGGATAAGGGGGATGGGGAGCAGGAAGACAGCAGCAAGGATGCGATCCCGAAGGAACT
TTCCTCCTCAGACTGCTCCATGTCCATGTGGGGCAGGTCGCTGAAGAGTTCGAAACCGTGCTCAGCACCGCGTTTGGGGCATGTGAGACC
GAGAGGCTTTGGGAAACTGACGCCGCTGTGAGAACGAGTTTAGCGGAGTCTATGGACGCTGCGAGCTTGTGGCCACAAGAGGGCGCCCCG
GAGCACGGCCCAGTCCCCGCCCCCGCTGGATGGGGCCCGGCCTCTTCCCAGCGTTCCTCCTCCGGCCCCAGGTCACCGCCAGCACGCGCC
TGCTTCCCGTCTGCGCGAGTCCACGCAGCTCCCCAGGCCCTTCACCAGCACAGCAGCAGCAGGCATGGCAGCAAGCGTGGAGCAGCGCGA
GGGCACCATCCAGGTGCAGGGCCAGGCCCTCTTCTTCCGAGAGGCCCTGCCCGGCAGTGGGCAGGCTCGCTTCTCTGTACTGCTGCTGCA
TGGTATTCGCTTCTCCTCCGAGACCTGGCAGAACCTGGGTACACTGCACAGGCTGGCCCAGGCTGGCTACCGGGCTGTGGCCATTGACCT
GCCAGACAGTCTCCATTCTGGAGCAGCGGTTGACACTGACAGAAGACAAGCTGAAGCAGTGTCTGGAGAACCAGCAGCTAATCATGCAGA
GAGCAACACCATGATCAGGGGAGCAGGAATCAGGAGCTCGGTGGATTTGCAGGTGGCAGGCCAGGGATTTGTACCATGGGACTTGGGTAA
ATAAAGGGGACTGAACTCTGTGGGAATCACATCCATACTGGAGCCCTGGATTTTTGCAGTTCTGCCCTCCACCTTGCTATCTGCACCAGG
AGGCTCTCCACCTGGCAGCCAGAGGTCCCCAGTGGGCCGGGCTCACACACAAATGATGCTTCAGACCCGAATGAGAGGACCACATTTTGC
TTAATGTAAAGGAGCCACTTGAAAATGTCTGCTCCTTCGGGGTCCTGAGATTGTGGCTCCCCCTCTGGAGGAGGTGGCTCCACGATGCCT
TGATTTTCACTCATCATTTGGACATGTGACTGGCTTTTCCTACCTCTGCCATGGTGTAGAAATTGATTGCACATTGATTGGATGAGCCGG
GGGTTTTCTCTAAATCTGACTAAAGGCCCAAAGTGGGCCCATCTGAGTCAGGTTTGTTGAGAACAAGCCCTCTCAAGTGGGTGGTGGCTT

>389_389_1_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000315877_POC1A_chr3_52110001_ENST00000394970_length(amino acids)=191AA_BP=132
MRACGHKRAPRSTAQSPPPLDGARPLPSVPPPAPGHRQHAPASRLRESTQLPRPFTSTAAAGMAASVEQREGTIQVQGQALFFREALPGS
GQARFSVLLLHGIRFSSETWQNLGTLHRLAQAGYRAVAIDLPDSLHSGAAVDTDRRQAEAVSGEPAANHAESNTMIRGAGIRSSVDLQVA

--------------------------------------------------------------
>389_389_2_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000361143_POC1A_chr3_52110001_ENST00000394970_length(transcript)=1041nt_BP=341nt
GCTGGATGGGGCCCGGCCTCTTCCCAGCGTTCCTCCTCCGGCCCCAGGTCACCGCCAGCACGCGCCTGCTTCCCGTCTGCGCGAGTCCAC
GCAGCTCCCCAGGCCCTTCACCAGCACAGCAGCAGCAGGCATGGCAGCAAGCGTGGAGCAGCGCGAGGGCACCATCCAGGTGCAGGGCCA
GGCCCTCTTCTTCCGAGAGGCCCTGCCCGGCAGTGGGCAGGCTCGCTTCTCTGTACTGCTGCTGCATGGTATTCGCTTCTCCTCCGAGAC
CTGGCAGAACCTGGGTACACTGCACAGGCTGGCCCAGGCTGGCTACCGGGCTGTGGCCATTGACCTGCCAGACAGTCTCCATTCTGGAGC
AGCGGTTGACACTGACAGAAGACAAGCTGAAGCAGTGTCTGGAGAACCAGCAGCTAATCATGCAGAGAGCAACACCATGATCAGGGGAGC
AGGAATCAGGAGCTCGGTGGATTTGCAGGTGGCAGGCCAGGGATTTGTACCATGGGACTTGGGTAAATAAAGGGGACTGAACTCTGTGGG
AATCACATCCATACTGGAGCCCTGGATTTTTGCAGTTCTGCCCTCCACCTTGCTATCTGCACCAGGAGGCTCTCCACCTGGCAGCCAGAG
GTCCCCAGTGGGCCGGGCTCACACACAAATGATGCTTCAGACCCGAATGAGAGGACCACATTTTGCTTAATGTAAAGGAGCCACTTGAAA
ATGTCTGCTCCTTCGGGGTCCTGAGATTGTGGCTCCCCCTCTGGAGGAGGTGGCTCCACGATGCCTTGATTTTCACTCATCATTTGGACA
TGTGACTGGCTTTTCCTACCTCTGCCATGGTGTAGAAATTGATTGCACATTGATTGGATGAGCCGGGGGTTTTCTCTAAATCTGACTAAA
GGCCCAAAGTGGGCCCATCTGAGTCAGGTTTGTTGAGAACAAGCCCTCTCAAGTGGGTGGTGGCTTTTCAGTGGCCCTGATTTCTGTTCC

>389_389_2_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000361143_POC1A_chr3_52110001_ENST00000394970_length(amino acids)=172AA_BP=113
LDGARPLPSVPPPAPGHRQHAPASRLRESTQLPRPFTSTAAAGMAASVEQREGTIQVQGQALFFREALPGSGQARFSVLLLHGIRFSSET

--------------------------------------------------------------
>389_389_3_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000395008_POC1A_chr3_52110001_ENST00000296484_length(transcript)=1233nt_BP=500nt
CTCCGGCCCCAGGTCACCGCCAGCACGCGCCTGCTTCCCGTCTGCGCGAGTCCACGCAGCTCCCCAGATCAAGAAGCTGAGGCCCCAGGT
TACACACTAAAGTAAATGGCAGAGGCAGAAATAACACCTATGTCCTCCTGACCCCAAGGCATGTTCTTAAAGTTCTGGAAACCTCCTGGA
GGCTTCCTTGCTGCTCCTCTGGGACTGCCACCCTGGGCAGGGTGTTCTGTGGCCCCTCATCATCGTGGTTTTGAACCACAGGCCCTTCAC
CAGCACAGCAGCAGCAGGCATGGCAGCAAGCGTGGAGCAGCGCGAGGGCACCATCCAGGTGCAGGGCCAGGCCCTCTTCTTCCGAGAGGC
CCTGCCCGGCAGTGGGCAGGCTCGCTTCTCTGTACTGCTGCTGCATGGTATTCGCTTCTCCTCCGAGACCTGGCAGAACCTGGGTACACT
GCACAGGCTGGCCCAGGCTGGCTACCGGGCTGTGGCCATTGACCTGCCAGACAGTCTCCATTCTGGAGCAGCGGTTGACACTGACAGAAG
ACAAGCTGAAGCAGTGTCTGGAGAACCAGCAGCTAATCATGCAGAGAGCAACACCATGATCAGGGGAGCAGGAATCAGGAGCTCGGTGGA
TTTGCAGGTGGCAGGCCAGGGATTTGTACCATGGGACTTGGGTAAATAAAGGGGACTGAACTCTGTGGGAATCACATCCATACTGGAGCC
CTGGATTTTTGCAGTTCTGCCCTCCACCTTGCTATCTGCACCAGGAGGCTCTCCACCTGGCAGCCAGAGGTCCCCAGTGGGCCGGGCTCA
CACACAAATGATGCTTCAGACCCGAATGAGAGGACCACATTTTGCTTAATGTAAAGGAGCCACTTGAAAATGTCTGCTCCTTCGGGGTCC
TGAGATTGTGGCTCCCCCTCTGGAGGAGGTGGCTCCACGATGCCTTGATTTTCACTCATCATTTGGACATGTGACTGGCTTTTCCTACCT
CTGCCATGGTGTAGAAATTGATTGCACATTGATTGGATGAGCCGGGGGTTTTCTCTAAATCTGACTAAAGGCCCAAAGTGGGCCCATCTG
AGTCAGGTTTGTTGAGAACAAGCCCTCTCAAGTGGGTGGTGGCTTTTCAGTGGCCCTGATTTCTGTTCCACACGTGTTCACTGGAGCCAG

>389_389_3_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000395008_POC1A_chr3_52110001_ENST00000296484_length(amino acids)=173AA_BP=1
MACHLQIHRAPDSCSPDHGVALCMISCWFSRHCFSLSSVSVNRCSRMETVWQVNGHSPVASLGQPVQCTQVLPGLGGEANTMQQQYREAS

--------------------------------------------------------------
>389_389_4_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000461108_POC1A_chr3_52110001_ENST00000394970_length(transcript)=996nt_BP=296nt
AGGTCACCGCCAGCACGCGCCTGCTTCCCGTCTGCGCGAGTCCACGCAGCTCCCCAGGCCCTTCACCAGCACAGCAGCAGCAGGCATGGC
AGCAAGCGTGGAGCAGCGCGAGGGCACCATCCAGGTGCAGGGCCAGGCCCTCTTCTTCCGAGAGGCCCTGCCCGGCAGTGGGCAGGCTCG
CTTCTCTGTACTGCTGCTGCATGGTATTCGCTTCTCCTCCGAGACCTGGCAGAACCTGGGTACACTGCACAGGCTGGCCCAGGCTGGCTA
CCGGGCTGTGGCCATTGACCTGCCAGACAGTCTCCATTCTGGAGCAGCGGTTGACACTGACAGAAGACAAGCTGAAGCAGTGTCTGGAGA
ACCAGCAGCTAATCATGCAGAGAGCAACACCATGATCAGGGGAGCAGGAATCAGGAGCTCGGTGGATTTGCAGGTGGCAGGCCAGGGATT
TGTACCATGGGACTTGGGTAAATAAAGGGGACTGAACTCTGTGGGAATCACATCCATACTGGAGCCCTGGATTTTTGCAGTTCTGCCCTC
CACCTTGCTATCTGCACCAGGAGGCTCTCCACCTGGCAGCCAGAGGTCCCCAGTGGGCCGGGCTCACACACAAATGATGCTTCAGACCCG
AATGAGAGGACCACATTTTGCTTAATGTAAAGGAGCCACTTGAAAATGTCTGCTCCTTCGGGGTCCTGAGATTGTGGCTCCCCCTCTGGA
GGAGGTGGCTCCACGATGCCTTGATTTTCACTCATCATTTGGACATGTGACTGGCTTTTCCTACCTCTGCCATGGTGTAGAAATTGATTG
CACATTGATTGGATGAGCCGGGGGTTTTCTCTAAATCTGACTAAAGGCCCAAAGTGGGCCCATCTGAGTCAGGTTTGTTGAGAACAAGCC
CTCTCAAGTGGGTGGTGGCTTTTCAGTGGCCCTGATTTCTGTTCCACACGTGTTCACTGGAGCCAGGTGACTTCCTCCTTGCGTGAGTGA

>389_389_4_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000461108_POC1A_chr3_52110001_ENST00000394970_length(amino acids)=147AA_BP=88
MRESTQLPRPFTSTAAAGMAASVEQREGTIQVQGQALFFREALPGSGQARFSVLLLHGIRFSSETWQNLGTLHRLAQAGYRAVAIDLPDS

--------------------------------------------------------------
>389_389_5_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000483233_POC1A_chr3_52110001_ENST00000474012_length(transcript)=1250nt_BP=718nt
CCCGGCGCCAGCGGCCGCGTCGGCGCGGATGTCCCCGCCCGCCTCTGGTTCGGGCCTCAGCGAGATTACTGGAGGATTAGATCCGGATCC
CGTCCCCGGGCAGCGGCCGCCGCGGCCAGCGCCGCCCCGCGAGTTGCGAGCTCCGGGCTGGCCCTGCTCTGACAGGCTCGCCCCGCCCCA
CACGACACGCCTGCCACTCCTGCCCCCAGGTCGCTGAAGAGTTCGAAACCGTGCTCAGCACCGCGTTTGGGGCATGTGAGACCGAGAGGC
TTTGGGAAACTGACGCCGCTGTGAGAACGAGTTTAGCGGAGTCTATGGACGCTGCGAGCTTGTGGCCACAAGAGGGCGCCCCGGAGCACG
GCCCAGTCCCCGCCCCCGCTGGATGGGGCCCGGCCTCTTCCCAGCGTTCCTCCTCCGGCCCCAGGTCACCGCCAGCACGCGCCTGCTTCC
CGTCTGCGCGAGTCCACGCAGCTCCCCAGGCCCTTCACCAGCACAGCAGCAGCAGGCATGGCAGCAAGCGTGGAGCAGCGCGAGGGCACC
ATCCAGGTGCAGGGCCAGGCCCTCTTCTTCCGAGAGGCCCTGCCCGGCAGTGGGCAGGCTCGCTTCTCTGTACTGCTGCTGCATGGTATT
CGCTTCTCCTCCGAGACCTGGCAGAACCTGGGTACACTGCACAGGCTGGCCCAGGCTGGCTACCGGGCTGTGGCCATTGACCTGCCAGAC
AGTCTCCATTCTGGAGCAGCGGTTGACACTGACAGAAGACAAGCTGAAGCAGTGTCTGGAGAACCAGCAGCTAATCATGCAGAGAGCAAC
ACCATGATCAGGGGAGCAGGAATCAGGAGCTCGGTGGATTTGCAGGTGGCAGGCCAGGGATTTGTACCATGGGACTTGGGTAAATAAAGG
GGACTGAACTCTGTGGGAATCACATCCATACTGGAGCCCTGGATTTTTGCAGTTCTGCCCTCCACCTTGCTATCTGCACCAGGAGGCTCT
CCACCTGGCAGCCAGAGGTCCCCAGTGGGCCGGGCTCACACACAAATGATGCTTCAGACCCGAATGAGAGGACCACATTTTGCTTAATGT
AAAGGAGCCACTTGAAAATGTCTGCTCCTTCGGGGTCCTGAGATTGTGGCTCCCCCTCTGGAGGAGGTGGCTCCACGATGCCTTGATTTT

>389_389_5_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000483233_POC1A_chr3_52110001_ENST00000474012_length(amino acids)=191AA_BP=132
MRACGHKRAPRSTAQSPPPLDGARPLPSVPPPAPGHRQHAPASRLRESTQLPRPFTSTAAAGMAASVEQREGTIQVQGQALFFREALPGS
GQARFSVLLLHGIRFSSETWQNLGTLHRLAQAGYRAVAIDLPDSLHSGAAVDTDRRQAEAVSGEPAANHAESNTMIRGAGIRSSVDLQVA

--------------------------------------------------------------
>389_389_6_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000525795_POC1A_chr3_52110001_ENST00000394970_length(transcript)=1105nt_BP=405nt
CTCTTCCCAGCGTTCCTCCTCCGGCCCCAGGTCACCGCCAGCACGCGCCTGCTTCCCGTCTGCGCGAGTCCACGCAGCTCCCCAGATCAA
GAAGCTGAGGCCCCAGGTTACACACTAAAGTAAATGGCAGAGGCAGAAATAACACCTATGTCCTCCTGACCCCAAGGCCCTTCACCAGCA
CAGCAGCAGCAGGCATGGCAGCAAGCGTGGAGCAGCGCGAGGGCACCATCCAGGTGCAGGGCCAGGCCCTCTTCTTCCGAGAGGCCCTGC
CCGGCAGTGGGCAGGCTCGCTTCTCTGTACTGCTGCTGCATGGTATTCGCTTCTCCTCCGAGACCTGGCAGAACCTGGGTACACTGCACA
GGCTGGCCCAGGCTGGCTACCGGGCTGTGGCCATTGACCTGCCAGACAGTCTCCATTCTGGAGCAGCGGTTGACACTGACAGAAGACAAG
CTGAAGCAGTGTCTGGAGAACCAGCAGCTAATCATGCAGAGAGCAACACCATGATCAGGGGAGCAGGAATCAGGAGCTCGGTGGATTTGC
AGGTGGCAGGCCAGGGATTTGTACCATGGGACTTGGGTAAATAAAGGGGACTGAACTCTGTGGGAATCACATCCATACTGGAGCCCTGGA
TTTTTGCAGTTCTGCCCTCCACCTTGCTATCTGCACCAGGAGGCTCTCCACCTGGCAGCCAGAGGTCCCCAGTGGGCCGGGCTCACACAC
AAATGATGCTTCAGACCCGAATGAGAGGACCACATTTTGCTTAATGTAAAGGAGCCACTTGAAAATGTCTGCTCCTTCGGGGTCCTGAGA
TTGTGGCTCCCCCTCTGGAGGAGGTGGCTCCACGATGCCTTGATTTTCACTCATCATTTGGACATGTGACTGGCTTTTCCTACCTCTGCC
ATGGTGTAGAAATTGATTGCACATTGATTGGATGAGCCGGGGGTTTTCTCTAAATCTGACTAAAGGCCCAAAGTGGGCCCATCTGAGTCA
GGTTTGTTGAGAACAAGCCCTCTCAAGTGGGTGGTGGCTTTTCAGTGGCCCTGATTTCTGTTCCACACGTGTTCACTGGAGCCAGGTGAC

>389_389_6_ABHD14B-POC1A_ABHD14B_chr3_52005476_ENST00000525795_POC1A_chr3_52110001_ENST00000394970_length(amino acids)=148AA_BP=1
MACHLQIHRAPDSCSPDHGVALCMISCWFSRHCFSLSSVSVNRCSRMETVWQVNGHSPVASLGQPVQCTQVLPGLGGEANTMQQQYREAS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ABHD14B-POC1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ABHD14B-POC1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ABHD14B-POC1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3542022SHORT STATURE, ONYCHODYSPLASIA, FACIAL DYSMORPHISM, AND HYPOTRICHOSIS SYNDROME5GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0013336Dwarfism1GENOMICS_ENGLAND
TgeneC0342573PITUITARY DWARFISM I1GENOMICS_ENGLAND
TgeneC0431350Primary microcephaly1GENOMICS_ENGLAND
TgeneC3553735Microcephaly in adulthood1GENOMICS_ENGLAND
TgeneC3808988FANCONI ANEMIA, COMPLEMENTATION GROUP Q1GENOMICS_ENGLAND