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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CBR4-ALG8 (FusionGDB2 ID:HG84869TG79053)

Fusion Gene Summary for CBR4-ALG8

check button Fusion gene summary
Fusion gene informationFusion gene name: CBR4-ALG8
Fusion gene ID: hg84869tg79053
HgeneTgene
Gene symbol

CBR4

ALG8

Gene ID

84869

79053

Gene namecarbonyl reductase 4ALG8 alpha-1,3-glucosyltransferase
SynonymsSDR45C1CDG1H|PCLD3
Cytomap('CBR4')('ALG8')

4q32.3

11q14.1

Type of geneprotein-codingprotein-coding
Descriptioncarbonyl reductase family member 43-ketoacyl-[acyl-carrier-protein] reductase beta subunit3-oxoacyl-[acyl-carrier-protein] reductaseKAR beta subunitcarbonic reductase 4quinone reductase CBR4short chain dehydrogenase/reductase family 45C member 1probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferaseHUSSY-02asparagine-linked glycosylation 8 alpha-13-glucosyltransferase-like proteinasparagine-linked glycosylation 8 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)asp
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000306193, ENST00000509108, 
ENST00000504480, 
Fusion gene scores* DoF score6 X 4 X 5=1206 X 6 X 8=288
# samples 610
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CBR4 [Title/Abstract] AND ALG8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCBR4(169923221)-ALG8(77820627), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCBR4

GO:0051289

protein homotetramerization

19000905

HgeneCBR4

GO:0051290

protein heterotetramerization

25203508

HgeneCBR4

GO:0055114

oxidation-reduction process

25203508


check buttonFusion gene breakpoints across CBR4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ALG8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4G6CBR4chr4

169923221

-ALG8chr11

77820627

-


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Fusion Gene ORF analysis for CBR4-ALG8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000306193ENST00000532552CBR4chr4

169923221

-ALG8chr11

77820627

-
5UTR-3CDSENST00000509108ENST00000299626CBR4chr4

169923221

-ALG8chr11

77820627

-
5UTR-3CDSENST00000509108ENST00000376156CBR4chr4

169923221

-ALG8chr11

77820627

-
5UTR-5UTRENST00000509108ENST00000532552CBR4chr4

169923221

-ALG8chr11

77820627

-
In-frameENST00000306193ENST00000299626CBR4chr4

169923221

-ALG8chr11

77820627

-
In-frameENST00000306193ENST00000376156CBR4chr4

169923221

-ALG8chr11

77820627

-
intron-3CDSENST00000504480ENST00000299626CBR4chr4

169923221

-ALG8chr11

77820627

-
intron-3CDSENST00000504480ENST00000376156CBR4chr4

169923221

-ALG8chr11

77820627

-
intron-5UTRENST00000504480ENST00000532552CBR4chr4

169923221

-ALG8chr11

77820627

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000306193CBR4chr4169923221-ENST00000299626ALG8chr1177820627-14097041151386423
ENST00000306193CBR4chr4169923221-ENST00000376156ALG8chr1177820627-14797041151209364

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000306193ENST00000299626CBR4chr4169923221-ALG8chr1177820627-0.0007934080.9992066
ENST00000306193ENST00000376156CBR4chr4169923221-ALG8chr1177820627-0.001171420.9988286

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Fusion Genomic Features for CBR4-ALG8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CBR4-ALG8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:169923221/chr11:77820627)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBR4chr4:169923221chr11:77820627ENST00000306193-4511_14178238.0Nucleotide bindingNADP
HgeneCBR4chr4:169923221chr11:77820627ENST00000306193-4534_35178238.0Nucleotide bindingNADP
HgeneCBR4chr4:169923221chr11:77820627ENST00000306193-4583_85178238.0Nucleotide bindingNADP
TgeneALG8chr4:169923221chr11:77820627ENST00000299626713334_354299527.0TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000299626713368_388299527.0TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000299626713389_409299527.0TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000299626713427_449299527.0TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000299626713461_481299527.0TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000299626713488_508299527.0TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000376156714334_354299516.6666666666666TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000376156714368_388299516.6666666666666TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000376156714389_409299516.6666666666666TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000376156714427_449299516.6666666666666TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000376156714461_481299516.6666666666666TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000376156714488_508299516.6666666666666TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBR4chr4:169923221chr11:77820627ENST00000306193-45181_183178238.0Nucleotide bindingNADP
HgeneCBR4chr4:169923221chr11:77820627ENST00000504480-1411_140180.0Nucleotide bindingNADP
HgeneCBR4chr4:169923221chr11:77820627ENST00000504480-14181_1830180.0Nucleotide bindingNADP
HgeneCBR4chr4:169923221chr11:77820627ENST00000504480-1434_350180.0Nucleotide bindingNADP
HgeneCBR4chr4:169923221chr11:77820627ENST00000504480-1483_850180.0Nucleotide bindingNADP
TgeneALG8chr4:169923221chr11:77820627ENST00000299626713103_122299527.0TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000299626713143_163299527.0TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000299626713188_208299527.0TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000299626713238_258299527.0TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST000002996267134_24299527.0TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000376156714103_122299516.6666666666666TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000376156714143_163299516.6666666666666TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000376156714188_208299516.6666666666666TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST00000376156714238_258299516.6666666666666TransmembraneHelical
TgeneALG8chr4:169923221chr11:77820627ENST000003761567144_24299516.6666666666666TransmembraneHelical


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Fusion Gene Sequence for CBR4-ALG8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13415_13415_1_CBR4-ALG8_CBR4_chr4_169923221_ENST00000306193_ALG8_chr11_77820627_ENST00000299626_length(transcript)=1409nt_BP=704nt
ATTACTATTGTGCGGCTGCAGGAGGTGTCGAGCGGCGTTATTTTTTTTTGCGGTTTGCCTTTTTTTTTCTTTTTTTTTTTTTTGGAACCG
CGGTTGTTTAAAAGCCTGAGGGAACCTGGAGAGGGGCTCCCACTCCCTACCCTCTTTCCTCCGAGTTTGTGACTCCGAGATGGACAAAGT
GTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGTTAATGGCCCGGAAAGGCTACCGACTGGCGGTCATTGCCAG
AAACCTGGAAGGGGCCAAAGCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAACATGATGTTCA
AAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTGGTAAATGCAGCTGGTATTAACAGGGATGGTCTTTTAGTAAG
AACAAAAACTGAAGATATGGTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGGACTATGATTCA
ACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAAGGCAACTCTGGCCAGTCCGTTTACAGTGCCAGTAAAGGAGG
ATTAGTTGGATTTTCACGTGCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGGTTTGAAATTGAAATT
TCTTGATCCCAACAATATTCCCAAGGCCTCAATGACAAGTGGTTTGGTTCAGCAGTTCCAACACACAGTCCTTCCCTCAGTGACTCCCTT
GGCAACCCTCATCTGCACACTGATTGCCATATTGCCCTCTATTTTCTGTCTTTGGTTTAAACCCCAAGGGCCCAGAGGCTTTCTCCGATG
TCTAACTCTTTGTGCCTTGAGCTCCTTTATGTTTGGGTGGCATGTTCATGAAAAAGCCATACTTCTAGCAATTCTCCCAATGAGCCTTTT
GTCTGTGGGAAAAGCAGGAGACGCTTCGATTTTTCTGATTCTGACCACAACAGGACATTATTCCCTCTTTCCTCTGCTCTTCACTGCACC
AGAACTTCCCATTAAAATCTTACTCATGTTACTATTCACCATATATAGTATTTCGTCACTGAAGACTTTATTCAGAAAAGAAAAACCTCT
TTTTAATTGGATGGAAACTTTCTACCTGCTTGGCCTGGGGCCTCTGGAAGTCTGCTGTGAATTTGTATTCCCTTTCACCTCCTGGAAGGT
GAAGTACCCCTTCATCCCTTTGTTACTAACCTCAGTGTATTGTGCAGTAGGCATCACATATGCTTGGTTCAAACTGTATGTTTCAGTATT

>13415_13415_1_CBR4-ALG8_CBR4_chr4_169923221_ENST00000306193_ALG8_chr11_77820627_ENST00000299626_length(amino acids)=423AA_BP=196
MERGSHSLPSFLRVCDSEMDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEK
HLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRAL
AKEVARKKIRVNVVAPGLKLKFLDPNNIPKASMTSGLVQQFQHTVLPSVTPLATLICTLIAILPSIFCLWFKPQGPRGFLRCLTLCALSS
FMFGWHVHEKAILLAILPMSLLSVGKAGDASIFLILTTTGHYSLFPLLFTAPELPIKILLMLLFTIYSISSLKTLFRKEKPLFNWMETFY

--------------------------------------------------------------
>13415_13415_2_CBR4-ALG8_CBR4_chr4_169923221_ENST00000306193_ALG8_chr11_77820627_ENST00000376156_length(transcript)=1479nt_BP=704nt
ATTACTATTGTGCGGCTGCAGGAGGTGTCGAGCGGCGTTATTTTTTTTTGCGGTTTGCCTTTTTTTTTCTTTTTTTTTTTTTTGGAACCG
CGGTTGTTTAAAAGCCTGAGGGAACCTGGAGAGGGGCTCCCACTCCCTACCCTCTTTCCTCCGAGTTTGTGACTCCGAGATGGACAAAGT
GTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGTTAATGGCCCGGAAAGGCTACCGACTGGCGGTCATTGCCAG
AAACCTGGAAGGGGCCAAAGCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAACATGATGTTCA
AAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTGGTAAATGCAGCTGGTATTAACAGGGATGGTCTTTTAGTAAG
AACAAAAACTGAAGATATGGTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGGACTATGATTCA
ACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAAGGCAACTCTGGCCAGTCCGTTTACAGTGCCAGTAAAGGAGG
ATTAGTTGGATTTTCACGTGCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGGTTTGAAATTGAAATT
TCTTGATCCCAACAATATTCCCAAGGCCTCAATGACAAGTGGTTTGGTTCAGCAGTTCCAACACACAGTCCTTCCCTCAGTGACTCCCTT
GGCAACCCTCATCTGCACACTGATTGCCATATTGCCCTCTATTTTCTGTCTTTGGTTTAAACCCCAAGGGCCCAGAGGCTTTCTCCGATG
TCTAACTCTTTGTGCCTTGAGCTCCTTTATGTTTGGGTGGCATGTTCATGAAAAAGCCATACTTCTAGCAATTCTCCCAATGAGCCTTTT
GTCTGTGGGAAAAGCAGGAGACGCTTCGATTTTTCTGATTCTGACCACAACAGGACATTATTCCCTCTTTCCTCTGCTCTTCACTGCACC
AGAACTTCCCATTAAAATCTTACTCATGTTACTATTCACCATATATAGTATTTCGTCACTGAAGACTTTATTCAGACGGAGTTTCACCCT
TGTTGCCCAGGCTGGAGTGCAATGGCACGATCTCAGCTAACTGAAACCTCCGCCTCCCAGAAAAGAAAAACCTCTTTTTAATTGGATGGA
AACTTTCTACCTGCTTGGCCTGGGGCCTCTGGAAGTCTGCTGTGAATTTGTATTCCCTTTCACCTCCTGGAAGGTGAAGTACCCCTTCAT
CCCTTTGTTACTAACCTCAGTGTATTGTGCAGTAGGCATCACATATGCTTGGTTCAAACTGTATGTTTCAGTATTGATTGACTCTGCTAT

>13415_13415_2_CBR4-ALG8_CBR4_chr4_169923221_ENST00000306193_ALG8_chr11_77820627_ENST00000376156_length(amino acids)=364AA_BP=196
MERGSHSLPSFLRVCDSEMDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEK
HLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRAL
AKEVARKKIRVNVVAPGLKLKFLDPNNIPKASMTSGLVQQFQHTVLPSVTPLATLICTLIAILPSIFCLWFKPQGPRGFLRCLTLCALSS
FMFGWHVHEKAILLAILPMSLLSVGKAGDASIFLILTTTGHYSLFPLLFTAPELPIKILLMLLFTIYSISSLKTLFRRSFTLVAQAGVQW

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Fusion Gene PPI Analysis for CBR4-ALG8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CBR4-ALG8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CBR4-ALG8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC2931002Congenital disorder of glycosylation type 1H4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0011581Depressive disorder1PSYGENET
TgeneC0158683Polycystic liver disease1GENOMICS_ENGLAND
TgeneC1691228Cystic Kidney Diseases1GENOMICS_ENGLAND
TgeneC4551631Cystic liver disease1GENOMICS_ENGLAND
TgeneC4693472POLYCYSTIC LIVER DISEASE 3 WITH OR WITHOUT KIDNEY CYSTS1GENOMICS_ENGLAND