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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATAD1-RNLS (FusionGDB2 ID:HG84896TG55328)

Fusion Gene Summary for ATAD1-RNLS

check button Fusion gene summary
Fusion gene informationFusion gene name: ATAD1-RNLS
Fusion gene ID: hg84896tg55328
HgeneTgene
Gene symbol

ATAD1

RNLS

Gene ID

84896

55328

Gene nameATPase family AAA domain containing 1renalase, FAD dependent amine oxidase
SynonymsAFDC1|FNP001|HKPX4|Msp1|THORASEC10orf59|RENALASE
Cytomap('ATAD1')('RNLS')

10q23.31

10q23.31

Type of geneprotein-codingprotein-coding
DescriptionATPase family AAA domain-containing protein 1renalaseMAO-Calpha-NAD(P)H oxidase/anomerasemonoamine oxidase-C
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000308448, ENST00000328142, 
ENST00000541004, ENST00000495903, 
ENST00000400215, 
ENST00000495903, 
ENST00000308448, ENST00000328142, 
ENST00000400215, ENST00000541004, 
Fusion gene scores* DoF score11 X 8 X 7=6168 X 7 X 5=280
# samples 129
** MAII scorelog2(12/616*10)=-2.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATAD1 [Title/Abstract] AND RNLS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATAD1(89574195)-RNLS(90122482), # samples:3
Anticipated loss of major functional domain due to fusion event.ATAD1-RNLS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD1-RNLS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD1-RNLS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRNLS

GO:0010459

negative regulation of heart rate

15841207

TgeneRNLS

GO:0045776

negative regulation of blood pressure

15841207


check buttonFusion gene breakpoints across ATAD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RNLS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-A48Y-01AATAD1chr10

89574195

-RNLSchr10

90122482

-
ChimerDB4LUADTCGA-55-A48YATAD1chr10

89574195

-RNLSchr10

90122482

-


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Fusion Gene ORF analysis for ATAD1-RNLS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000308448ENST00000466945ATAD1chr10

89574195

-RNLSchr10

90122482

-
5CDS-5UTRENST00000328142ENST00000466945ATAD1chr10

89574195

-RNLSchr10

90122482

-
5CDS-5UTRENST00000541004ENST00000466945ATAD1chr10

89574195

-RNLSchr10

90122482

-
5UTR-3CDSENST00000495903ENST00000331772ATAD1chr10

89574195

-RNLSchr10

90122482

-
5UTR-3CDSENST00000495903ENST00000371947ATAD1chr10

89574195

-RNLSchr10

90122482

-
5UTR-3CDSENST00000495903ENST00000437752ATAD1chr10

89574195

-RNLSchr10

90122482

-
5UTR-5UTRENST00000495903ENST00000466945ATAD1chr10

89574195

-RNLSchr10

90122482

-
Frame-shiftENST00000328142ENST00000331772ATAD1chr10

89574195

-RNLSchr10

90122482

-
Frame-shiftENST00000328142ENST00000371947ATAD1chr10

89574195

-RNLSchr10

90122482

-
Frame-shiftENST00000328142ENST00000437752ATAD1chr10

89574195

-RNLSchr10

90122482

-
In-frameENST00000308448ENST00000331772ATAD1chr10

89574195

-RNLSchr10

90122482

-
In-frameENST00000308448ENST00000371947ATAD1chr10

89574195

-RNLSchr10

90122482

-
In-frameENST00000308448ENST00000437752ATAD1chr10

89574195

-RNLSchr10

90122482

-
In-frameENST00000541004ENST00000331772ATAD1chr10

89574195

-RNLSchr10

90122482

-
In-frameENST00000541004ENST00000371947ATAD1chr10

89574195

-RNLSchr10

90122482

-
In-frameENST00000541004ENST00000437752ATAD1chr10

89574195

-RNLSchr10

90122482

-
intron-3CDSENST00000400215ENST00000331772ATAD1chr10

89574195

-RNLSchr10

90122482

-
intron-3CDSENST00000400215ENST00000371947ATAD1chr10

89574195

-RNLSchr10

90122482

-
intron-3CDSENST00000400215ENST00000437752ATAD1chr10

89574195

-RNLSchr10

90122482

-
intron-5UTRENST00000400215ENST00000466945ATAD1chr10

89574195

-RNLSchr10

90122482

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000308448ATAD1chr1089574195-ENST00000371947RNLSchr1090122482-2060541567962131
ENST00000308448ATAD1chr1089574195-ENST00000437752RNLSchr1090122482-963541567962131
ENST00000308448ATAD1chr1089574195-ENST00000331772RNLSchr1090122482-14395415671043158
ENST00000541004ATAD1chr1089574195-ENST00000371947RNLSchr1090122482-2060541567962131
ENST00000541004ATAD1chr1089574195-ENST00000437752RNLSchr1090122482-963541567962131
ENST00000541004ATAD1chr1089574195-ENST00000331772RNLSchr1090122482-14395415671043158

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308448ENST00000371947ATAD1chr1089574195-RNLSchr1090122482-0.94937560.050624333
ENST00000308448ENST00000437752ATAD1chr1089574195-RNLSchr1090122482-0.350299630.6497004
ENST00000308448ENST00000331772ATAD1chr1089574195-RNLSchr1090122482-0.640430.35957003
ENST00000541004ENST00000371947ATAD1chr1089574195-RNLSchr1090122482-0.94937560.050624333
ENST00000541004ENST00000437752ATAD1chr1089574195-RNLSchr1090122482-0.350299630.6497004
ENST00000541004ENST00000331772ATAD1chr1089574195-RNLSchr1090122482-0.640430.35957003

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Fusion Genomic Features for ATAD1-RNLS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ATAD1-RNLS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:89574195/chr10:90122482)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATAD1chr10:89574195chr10:90122482ENST00000308448-2101_1554362.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89574195chr10:90122482ENST00000328142-191_1554362.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89574195chr10:90122482ENST00000541004-291_1554288.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89574195chr10:90122482ENST00000308448-21016_3254362.0TransmembraneHelical
HgeneATAD1chr10:89574195chr10:90122482ENST00000328142-1916_3254362.0TransmembraneHelical
HgeneATAD1chr10:89574195chr10:90122482ENST00000541004-2916_3254288.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATAD1chr10:89574195chr10:90122482ENST00000308448-210133_14054362.0Nucleotide bindingATP
HgeneATAD1chr10:89574195chr10:90122482ENST00000328142-19133_14054362.0Nucleotide bindingATP
HgeneATAD1chr10:89574195chr10:90122482ENST00000541004-29133_14054288.0Nucleotide bindingATP
HgeneATAD1chr10:89574195chr10:90122482ENST00000308448-21033_36154362.0Topological domainCytoplasmic
HgeneATAD1chr10:89574195chr10:90122482ENST00000328142-1933_36154362.0Topological domainCytoplasmic
HgeneATAD1chr10:89574195chr10:90122482ENST00000541004-2933_36154288.0Topological domainCytoplasmic
TgeneRNLSchr10:89574195chr10:90122482ENST000003317723761_62175343.0RegionNote=FAD-binding
TgeneRNLSchr10:89574195chr10:90122482ENST000003719473761_62175316.0RegionNote=FAD-binding


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Fusion Gene Sequence for ATAD1-RNLS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7334_7334_1_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000308448_RNLS_chr10_90122482_ENST00000331772_length(transcript)=1439nt_BP=541nt
AGCTGGTTCCCGTGGGGCCTCATGGGATGGTTGTCGTATCCTTCTGAGGTCCTTTAAGGACCGTCTCGGACCTGGGAACCCCCGGAGGAA
AGGTCACCCCGGTCTTCTCCCACGCCCTACCTCAGTGCCGCCCCCAAGCGCCCCGCAGCCCTTAGTATCTAGAGGATTAACCTCCAAGGG
CGTCCCGGGCCTCGCCTTGGCGTCCGGCCCGGCCTGGGCCCTTAGGGTCTGCTTAGCTCTTCCCCAAGACTCGTGCCATTCCCGAGGGAA
TCTTTGTCGGCATCCTGGTCACTGTGGGGGTTTGAGGTCGTCCCGGAAGACTTCAGAACCAGGCGAACCTAGACGAAGGCGGCTGGAATG
AACCAGGTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGAC
AATATTTGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACA
GTAATTAGTGAATGCCAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTATGAAGCTGGTACGAAG
ATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGCATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCA
TCAGAAATTGGGCCTTCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAGGATGTGCAAGAGTTA
GTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCAATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTTACAAAT
GCTGCTGCCAACTGTCCTGGCCAAATGACTCTGCATCACAAACCTTTCCTTGCATGTGGAGGGGATGGATTTACTCAGTCCAACTTTGAT
GGCTGCATCACTTCTGCCCTATGTGTTCTGGAAGCTTTAAAGAATTATATTTAGTGCCTATATCCTTATTCTCTACATGTGTATTGGGTT
TTTATTTTCACAATTTTCTGTTATTGATTATTTTGTTTTCTATTTTGCTAAGAAAAATTACTGGAAAATTGTTCTTCACTTATTATCATT
TTTCATGTGGAGTATAAAATCAATTTTGTAATTTTGATAGTTACAACCCATGCTAGAATGGAAATTCCTCACACCTTGCACCTTCCCTAC
TTTTCTGAATTGCTATGACTACTCCTTGTTGGAGGAAAAGTGGTACTTAAAAAATAACAAACGACTCTCTCAAAAAAATTACATTAAATC

>7334_7334_1_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000308448_RNLS_chr10_90122482_ENST00000331772_length(amino acids)=158AA_BP=
MEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENIL

--------------------------------------------------------------
>7334_7334_2_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000308448_RNLS_chr10_90122482_ENST00000371947_length(transcript)=2060nt_BP=541nt
AGCTGGTTCCCGTGGGGCCTCATGGGATGGTTGTCGTATCCTTCTGAGGTCCTTTAAGGACCGTCTCGGACCTGGGAACCCCCGGAGGAA
AGGTCACCCCGGTCTTCTCCCACGCCCTACCTCAGTGCCGCCCCCAAGCGCCCCGCAGCCCTTAGTATCTAGAGGATTAACCTCCAAGGG
CGTCCCGGGCCTCGCCTTGGCGTCCGGCCCGGCCTGGGCCCTTAGGGTCTGCTTAGCTCTTCCCCAAGACTCGTGCCATTCCCGAGGGAA
TCTTTGTCGGCATCCTGGTCACTGTGGGGGTTTGAGGTCGTCCCGGAAGACTTCAGAACCAGGCGAACCTAGACGAAGGCGGCTGGAATG
AACCAGGTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGAC
AATATTTGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACA
GTAATTAGTGAATGCCAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTATGAAGCTGGTACGAAG
ATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGCATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCA
TCAGAAATTGGGCCTTCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAGGATGTGCAAGAGTTA
GTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCAATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTACCAAGT
GCTGGTGTGATTCTAGGATGTGCGAAGAGCCCCTGGATGATGGCGATTGGATTTCCCATCTGACTTCCTGGAAATTGGAGCACACAGTCA
GGTTTTATTTGATTTTTTTTTTTAAGGATACCACTTCACAGCCTTTAGGATAGCTATTATTTAGAAGCAAAACAGAAGATAAATGTTGGC
AAGGATGTGGAGATATTGGATTCCCTTGTGCAGTGCCGGTGGGAATGTAAAATGATGTAGCTACTATGGAAAATGATACGGCAATTTCTT
TAGAAATGAAATATAGAATTGCTGTATGATCTGCAGTTCCACATCTGGATATCTATCCAAAAGAAGTGAAAGTAGGGACTTGAACGAACA
TTTGTACACCAATGTTCACAGCGGCTTTATTCACAACAGCCAAAAGGTGGAAGCAACCCAGTGTCCATGGATAGATGAATAGATAAATAA
AATGTGGTATAAACATACAATGGGCTATTGTTTAGCCTTAAAAGGGAAGGAAATTCTGACATGCTGCAATATGGATGAAGCTTAAAGTCA
TTATGCAAAGTGGAATAAGCCTATCACAAAAAATAATATTACATAATTCTACTTATATGAGGAATCTAGAGCAGTCAGTTTCACAGAGAC
AGAAAATAGAATGGTGGTTGCCAAGGGCTGGGAGAAGAGGGCAATGGAGAGTGAGTGTTTAGTGGGTCAGAGTTTTAGTTTGGGAAGGTA
AAAAGTTCTGGAGATGGATGATGGTTATGGGTGCTCAACAGTGTGAATGTACTTAATGCCACAGAACTGCACATTTAAATGTGGTTAAAA
TCATCACTTTTATGTTATGTATATTTACCACAATAAATAAAGAAGTTGATATTTCTTATACTTACAAAGAGGAGAAGGGCATTTGCAAAT
CAACAAGAAGTGTGAGGCCCCTCTCTCTAGCAGAAAAATAGACTAAATCTATTTCTTTATCTTTTAACATCCTGTTTAAGGGAAATGCCA
AAACAAATGGGAAAAAATACACACACACAAATATATATGAACATGTTTTGCCTCATGAGTAATCAAAATGTGTACATATGTATGTTTATG

>7334_7334_2_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000308448_RNLS_chr10_90122482_ENST00000371947_length(amino acids)=131AA_BP=
MEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENIL

--------------------------------------------------------------
>7334_7334_3_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000308448_RNLS_chr10_90122482_ENST00000437752_length(transcript)=963nt_BP=541nt
AGCTGGTTCCCGTGGGGCCTCATGGGATGGTTGTCGTATCCTTCTGAGGTCCTTTAAGGACCGTCTCGGACCTGGGAACCCCCGGAGGAA
AGGTCACCCCGGTCTTCTCCCACGCCCTACCTCAGTGCCGCCCCCAAGCGCCCCGCAGCCCTTAGTATCTAGAGGATTAACCTCCAAGGG
CGTCCCGGGCCTCGCCTTGGCGTCCGGCCCGGCCTGGGCCCTTAGGGTCTGCTTAGCTCTTCCCCAAGACTCGTGCCATTCCCGAGGGAA
TCTTTGTCGGCATCCTGGTCACTGTGGGGGTTTGAGGTCGTCCCGGAAGACTTCAGAACCAGGCGAACCTAGACGAAGGCGGCTGGAATG
AACCAGGTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGAC
AATATTTGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACA
GTAATTAGTGAATGCCAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTATGAAGCTGGTACGAAG
ATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGCATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCA
TCAGAAATTGGGCCTTCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAGGATGTGCAAGAGTTA
GTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCAATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTACCAAGT

>7334_7334_3_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000308448_RNLS_chr10_90122482_ENST00000437752_length(amino acids)=131AA_BP=
MEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENIL

--------------------------------------------------------------
>7334_7334_4_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000541004_RNLS_chr10_90122482_ENST00000331772_length(transcript)=1439nt_BP=541nt
AGCTGGTTCCCGTGGGGCCTCATGGGATGGTTGTCGTATCCTTCTGAGGTCCTTTAAGGACCGTCTCGGACCTGGGAACCCCCGGAGGAA
AGGTCACCCCGGTCTTCTCCCACGCCCTACCTCAGTGCCGCCCCCAAGCGCCCCGCAGCCCTTAGTATCTAGAGGATTAACCTCCAAGGG
CGTCCCGGGCCTCGCCTTGGCGTCCGGCCCGGCCTGGGCCCTTAGGGTCTGCTTAGCTCTTCCCCAAGACTCGTGCCATTCCCGAGGGAA
TCTTTGTCGGCATCCTGGTCACTGTGGGGGTTTGAGGTCGTCCCGGAAGACTTCAGAACCAGGCGAACCTAGACGAAGGCGGCTGGAATG
AACCAGGTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGAC
AATATTTGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACA
GTAATTAGTGAATGCCAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTATGAAGCTGGTACGAAG
ATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGCATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCA
TCAGAAATTGGGCCTTCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAGGATGTGCAAGAGTTA
GTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCAATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTTACAAAT
GCTGCTGCCAACTGTCCTGGCCAAATGACTCTGCATCACAAACCTTTCCTTGCATGTGGAGGGGATGGATTTACTCAGTCCAACTTTGAT
GGCTGCATCACTTCTGCCCTATGTGTTCTGGAAGCTTTAAAGAATTATATTTAGTGCCTATATCCTTATTCTCTACATGTGTATTGGGTT
TTTATTTTCACAATTTTCTGTTATTGATTATTTTGTTTTCTATTTTGCTAAGAAAAATTACTGGAAAATTGTTCTTCACTTATTATCATT
TTTCATGTGGAGTATAAAATCAATTTTGTAATTTTGATAGTTACAACCCATGCTAGAATGGAAATTCCTCACACCTTGCACCTTCCCTAC
TTTTCTGAATTGCTATGACTACTCCTTGTTGGAGGAAAAGTGGTACTTAAAAAATAACAAACGACTCTCTCAAAAAAATTACATTAAATC

>7334_7334_4_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000541004_RNLS_chr10_90122482_ENST00000331772_length(amino acids)=158AA_BP=
MEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENIL

--------------------------------------------------------------
>7334_7334_5_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000541004_RNLS_chr10_90122482_ENST00000371947_length(transcript)=2060nt_BP=541nt
AGCTGGTTCCCGTGGGGCCTCATGGGATGGTTGTCGTATCCTTCTGAGGTCCTTTAAGGACCGTCTCGGACCTGGGAACCCCCGGAGGAA
AGGTCACCCCGGTCTTCTCCCACGCCCTACCTCAGTGCCGCCCCCAAGCGCCCCGCAGCCCTTAGTATCTAGAGGATTAACCTCCAAGGG
CGTCCCGGGCCTCGCCTTGGCGTCCGGCCCGGCCTGGGCCCTTAGGGTCTGCTTAGCTCTTCCCCAAGACTCGTGCCATTCCCGAGGGAA
TCTTTGTCGGCATCCTGGTCACTGTGGGGGTTTGAGGTCGTCCCGGAAGACTTCAGAACCAGGCGAACCTAGACGAAGGCGGCTGGAATG
AACCAGGTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGAC
AATATTTGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACA
GTAATTAGTGAATGCCAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTATGAAGCTGGTACGAAG
ATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGCATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCA
TCAGAAATTGGGCCTTCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAGGATGTGCAAGAGTTA
GTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCAATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTACCAAGT
GCTGGTGTGATTCTAGGATGTGCGAAGAGCCCCTGGATGATGGCGATTGGATTTCCCATCTGACTTCCTGGAAATTGGAGCACACAGTCA
GGTTTTATTTGATTTTTTTTTTTAAGGATACCACTTCACAGCCTTTAGGATAGCTATTATTTAGAAGCAAAACAGAAGATAAATGTTGGC
AAGGATGTGGAGATATTGGATTCCCTTGTGCAGTGCCGGTGGGAATGTAAAATGATGTAGCTACTATGGAAAATGATACGGCAATTTCTT
TAGAAATGAAATATAGAATTGCTGTATGATCTGCAGTTCCACATCTGGATATCTATCCAAAAGAAGTGAAAGTAGGGACTTGAACGAACA
TTTGTACACCAATGTTCACAGCGGCTTTATTCACAACAGCCAAAAGGTGGAAGCAACCCAGTGTCCATGGATAGATGAATAGATAAATAA
AATGTGGTATAAACATACAATGGGCTATTGTTTAGCCTTAAAAGGGAAGGAAATTCTGACATGCTGCAATATGGATGAAGCTTAAAGTCA
TTATGCAAAGTGGAATAAGCCTATCACAAAAAATAATATTACATAATTCTACTTATATGAGGAATCTAGAGCAGTCAGTTTCACAGAGAC
AGAAAATAGAATGGTGGTTGCCAAGGGCTGGGAGAAGAGGGCAATGGAGAGTGAGTGTTTAGTGGGTCAGAGTTTTAGTTTGGGAAGGTA
AAAAGTTCTGGAGATGGATGATGGTTATGGGTGCTCAACAGTGTGAATGTACTTAATGCCACAGAACTGCACATTTAAATGTGGTTAAAA
TCATCACTTTTATGTTATGTATATTTACCACAATAAATAAAGAAGTTGATATTTCTTATACTTACAAAGAGGAGAAGGGCATTTGCAAAT
CAACAAGAAGTGTGAGGCCCCTCTCTCTAGCAGAAAAATAGACTAAATCTATTTCTTTATCTTTTAACATCCTGTTTAAGGGAAATGCCA
AAACAAATGGGAAAAAATACACACACACAAATATATATGAACATGTTTTGCCTCATGAGTAATCAAAATGTGTACATATGTATGTTTATG

>7334_7334_5_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000541004_RNLS_chr10_90122482_ENST00000371947_length(amino acids)=131AA_BP=
MEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENIL

--------------------------------------------------------------
>7334_7334_6_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000541004_RNLS_chr10_90122482_ENST00000437752_length(transcript)=963nt_BP=541nt
AGCTGGTTCCCGTGGGGCCTCATGGGATGGTTGTCGTATCCTTCTGAGGTCCTTTAAGGACCGTCTCGGACCTGGGAACCCCCGGAGGAA
AGGTCACCCCGGTCTTCTCCCACGCCCTACCTCAGTGCCGCCCCCAAGCGCCCCGCAGCCCTTAGTATCTAGAGGATTAACCTCCAAGGG
CGTCCCGGGCCTCGCCTTGGCGTCCGGCCCGGCCTGGGCCCTTAGGGTCTGCTTAGCTCTTCCCCAAGACTCGTGCCATTCCCGAGGGAA
TCTTTGTCGGCATCCTGGTCACTGTGGGGGTTTGAGGTCGTCCCGGAAGACTTCAGAACCAGGCGAACCTAGACGAAGGCGGCTGGAATG
AACCAGGTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGAC
AATATTTGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACA
GTAATTAGTGAATGCCAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTATGAAGCTGGTACGAAG
ATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGCATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCA
TCAGAAATTGGGCCTTCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAGGATGTGCAAGAGTTA
GTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCAATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTACCAAGT

>7334_7334_6_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000541004_RNLS_chr10_90122482_ENST00000437752_length(amino acids)=131AA_BP=
MEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENIL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATAD1-RNLS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATAD1-RNLS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATAD1-RNLS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATAD1C4693933HYPEREKPLEXIA 43GENOMICS_ENGLAND;UNIPROT
HgeneATAD1C1835614Hereditary Hyperexplexia1ORPHANET
TgeneC2931456Prostate cancer, familial1CTD_human
TgeneC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human