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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXL20-BTBD1 (FusionGDB2 ID:HG84961TG53339)

Fusion Gene Summary for FBXL20-BTBD1

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXL20-BTBD1
Fusion gene ID: hg84961tg53339
HgeneTgene
Gene symbol

FBXL20

BTBD1

Gene ID

84961

53339

Gene nameF-box and leucine rich repeat protein 20BTB domain containing 1
SynonymsFbl2|Fbl20C15orf1|NS5ATP8
Cytomap('FBXL20')('BTBD1')

17q12

15q25.2

Type of geneprotein-codingprotein-coding
DescriptionF-box/LRR-repeat protein 20F-box protein FBL2BTB/POZ domain-containing protein 1BTB (POZ) domain containing 1HCV NS5A-transactivated protein 8hepatitis C virus NS5A-transactivated protein 8
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264658, ENST00000394294, 
ENST00000577399, ENST00000583610, 
Fusion gene scores* DoF score58 X 21 X 16=194885 X 5 X 4=100
# samples 615
** MAII scorelog2(61/19488*10)=-4.99763298545608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXL20 [Title/Abstract] AND BTBD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXL20(37499433)-BTBD1(83725297), # samples:2
Anticipated loss of major functional domain due to fusion event.FBXL20-BTBD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL20-BTBD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL20-BTBD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL20-BTBD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL20-BTBD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FBXL20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BTBD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A3TO-01AFBXL20chr17

37499433

-BTBD1chr15

83725297

-


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Fusion Gene ORF analysis for FBXL20-BTBD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264658ENST00000560015FBXL20chr17

37499433

-BTBD1chr15

83725297

-
5CDS-intronENST00000394294ENST00000560015FBXL20chr17

37499433

-BTBD1chr15

83725297

-
5CDS-intronENST00000577399ENST00000560015FBXL20chr17

37499433

-BTBD1chr15

83725297

-
5CDS-intronENST00000583610ENST00000560015FBXL20chr17

37499433

-BTBD1chr15

83725297

-
Frame-shiftENST00000264658ENST00000379403FBXL20chr17

37499433

-BTBD1chr15

83725297

-
Frame-shiftENST00000394294ENST00000379403FBXL20chr17

37499433

-BTBD1chr15

83725297

-
Frame-shiftENST00000577399ENST00000379403FBXL20chr17

37499433

-BTBD1chr15

83725297

-
Frame-shiftENST00000583610ENST00000261721FBXL20chr17

37499433

-BTBD1chr15

83725297

-
In-frameENST00000264658ENST00000261721FBXL20chr17

37499433

-BTBD1chr15

83725297

-
In-frameENST00000394294ENST00000261721FBXL20chr17

37499433

-BTBD1chr15

83725297

-
In-frameENST00000577399ENST00000261721FBXL20chr17

37499433

-BTBD1chr15

83725297

-
In-frameENST00000583610ENST00000379403FBXL20chr17

37499433

-BTBD1chr15

83725297

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000583610FBXL20chr1737499433-ENST00000379403BTBD1chr1583725297-14243582541114286
ENST00000394294FBXL20chr1737499433-ENST00000261721BTBD1chr1583725297-30183252211372383
ENST00000264658FBXL20chr1737499433-ENST00000261721BTBD1chr1583725297-30583652611412383
ENST00000577399FBXL20chr1737499433-ENST00000261721BTBD1chr1583725297-31064131981460420

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000583610ENST00000379403FBXL20chr1737499433-BTBD1chr1583725297-0.0008745450.9991254
ENST00000394294ENST00000261721FBXL20chr1737499433-BTBD1chr1583725297-0.0001519530.999848
ENST00000264658ENST00000261721FBXL20chr1737499433-BTBD1chr1583725297-0.0001464660.9998535
ENST00000577399ENST00000261721FBXL20chr1737499433-BTBD1chr1583725297-0.0002198030.99978024

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Fusion Genomic Features for FBXL20-BTBD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FBXL20-BTBD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37499433/chr15:83725297)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBTBD1chr17:37499433chr15:83725297ENST0000026172108184_284133483.0DomainBACK
TgeneBTBD1chr17:37499433chr15:83725297ENST0000037940307184_284133337.3333333333333DomainBACK

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-21522_6834437.0DomainF-box
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-21422_6834405.0DomainF-box
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-21622_6834411.6666666666667DomainF-box
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-215101_12634437.0RepeatNote=LRR 2
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-215127_15234437.0RepeatNote=LRR 3
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-215153_17834437.0RepeatNote=LRR 4
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-215179_20434437.0RepeatNote=LRR 5
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-215205_23034437.0RepeatNote=LRR 6
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-215231_25634437.0RepeatNote=LRR 7
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-215257_28234437.0RepeatNote=LRR 8
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-215283_30834437.0RepeatNote=LRR 9
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-215309_33434437.0RepeatNote=LRR 10
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-215335_36334437.0RepeatNote=LRR 11
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-215364_38834437.0RepeatNote=LRR 12
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-215389_41434437.0RepeatNote=LRR 13
HgeneFBXL20chr17:37499433chr15:83725297ENST00000264658-21574_10034437.0RepeatNote=LRR 1
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-214101_12634405.0RepeatNote=LRR 2
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-214127_15234405.0RepeatNote=LRR 3
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-214153_17834405.0RepeatNote=LRR 4
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-214179_20434405.0RepeatNote=LRR 5
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-214205_23034405.0RepeatNote=LRR 6
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-214231_25634405.0RepeatNote=LRR 7
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-214257_28234405.0RepeatNote=LRR 8
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-214283_30834405.0RepeatNote=LRR 9
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-214309_33434405.0RepeatNote=LRR 10
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-214335_36334405.0RepeatNote=LRR 11
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-214364_38834405.0RepeatNote=LRR 12
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-214389_41434405.0RepeatNote=LRR 13
HgeneFBXL20chr17:37499433chr15:83725297ENST00000394294-21474_10034405.0RepeatNote=LRR 1
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-216101_12634411.6666666666667RepeatNote=LRR 2
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-216127_15234411.6666666666667RepeatNote=LRR 3
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-216153_17834411.6666666666667RepeatNote=LRR 4
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-216179_20434411.6666666666667RepeatNote=LRR 5
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-216205_23034411.6666666666667RepeatNote=LRR 6
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-216231_25634411.6666666666667RepeatNote=LRR 7
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-216257_28234411.6666666666667RepeatNote=LRR 8
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-216283_30834411.6666666666667RepeatNote=LRR 9
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-216309_33434411.6666666666667RepeatNote=LRR 10
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-216335_36334411.6666666666667RepeatNote=LRR 11
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-216364_38834411.6666666666667RepeatNote=LRR 12
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-216389_41434411.6666666666667RepeatNote=LRR 13
HgeneFBXL20chr17:37499433chr15:83725297ENST00000583610-21674_10034411.6666666666667RepeatNote=LRR 1
TgeneBTBD1chr17:37499433chr15:83725297ENST000002617210825_31133483.0Compositional biasPoly-Pro
TgeneBTBD1chr17:37499433chr15:83725297ENST000003794030725_31133337.3333333333333Compositional biasPoly-Pro
TgeneBTBD1chr17:37499433chr15:83725297ENST000002617210869_145133483.0DomainBTB
TgeneBTBD1chr17:37499433chr15:83725297ENST000003794030769_145133337.3333333333333DomainBTB


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Fusion Gene Sequence for FBXL20-BTBD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29631_29631_1_FBXL20-BTBD1_FBXL20_chr17_37499433_ENST00000264658_BTBD1_chr15_83725297_ENST00000261721_length(transcript)=3058nt_BP=365nt
GGGGAGTGTTTTTGTTTTGGGTTGAAGTTGAGGCTGAGGAGAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGA
GGTGGTGGAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTCCCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGG
AACTCCCGGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCCGCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGG
GACGTGAACGGAGTGACCAAGAGCAGGTTTGAGATGTTCTCAAATAGTGATGAAGCTGTAATCAATAAAAAACTTCCCAAAGAACTCCTG
TTACGATTTCTATATTCAGATGAAGTTCAAATTGGTCCAGAAACAGTTATGACCACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCC
TTGGAAGCACACTGTGTAGAATTTCTCACCAAACATCTTAGGGCAGATAATGCCTTTATGTTACTTACTCAGGCTCGATTATTTGATGAA
CCTCAGCTTGCTAGTCTTTGTCTAGATACAATAGACAAAAGCACAATGGATGCAATAAGTGCAGAAGGGTTTACTGATATTGATATAGAT
ACACTCTGTGCAGTTTTAGAGAGAGACACACTCAGTATTCGAGAAAGTCGACTTTTTGGAGCTGTTGTACGCTGGGCAGAAGCAGAATGT
CAGAGACAACAATTACCTGTGACTTTTGGGAATAAACAAAAAGTTCTAGGAAAAGCACTTTCCTTAATCCGGTTCCCACTGATGACAATT
GAGGAATTTGCAGCAGGTCCTGCTCAATCTGGAATTTTGTCAGATCGTGAAGTGGTAAACCTCTTTCTTCATTTTACTGTCAACCCTAAA
CCCCGAGTTGAATACATTGACCGACCAAGATGCTGTCTCAGGGGAAAGGAATGCTGCATCAATAGATTCCAGCAAGTAGAAAGCCGCTGG
GGTTACAGTGGGACGAGTGATCGAATCAGATTCACAGTTAATAGAAGGATCTCTATAGTTGGATTTGGCTTGTATGGATCTATTCATGGC
CCTACAGATTATCAAGTGAATATACAGATCATTGAATATGAGAAAAAGCAAACCCTGGGACAGAATGATACCGGCTTTAGTTGTGATGGG
ACAGCTAACACATTCAGGGTCATGTTCAAGGAACCCATAGAGATCCTGCCCAATGTGTGCTACACAGCATGTGCAACACTCAAAGGTCCA
GATTCCCACTATGGCACAAAAGGATTGAAGAAAGTAGTGCATGAGACACCTGCTGCAAGCAAGACTGTTTTTTTCTTTTTTAGTTCCCCT
GGCAATAATAATGGCACTTCAATAGAAGATGGACAAATTCCAGAAATCATATTTTATACATAATTTAGCATTATAATACATCTTGGCTAA
ATAATACCATACAATCTAGTGTCAAAAACATAAATGGCCACAAAAAAGTAGTTTGAGTGTTATGAATATTTAAAATTGTAAGATAAGAAA
CAGTTTCTTAGAGCAGATAGAAAAATGCTTATTTAAATCTTTGCATGATTTAAAAACAGATTTTCCATTTTCTTACAACTTTAAGAGAAA
AGAACTGGGTTTAATGGTTTAAAAAAAAGCACAGCTTTTTCACCTTCATCTTGTATAATTTCATAGATTGGCTGACTTAGGGTCTTTCAA
TAGTTTGGGAATTGAAAGATTCTTGTTATATATAGCTAGTTTGGGTTTGTTTTTGTTTTAACTATTTTGAAGGTTAGGTGAGATGGGCAA
ATAGGCTTAACTATTTTGAAGGTTGGATGAAAAGAGATGGGTCAGTATTCCTACAGAATTCTTATTAACTCAAATAACTAAATTTCAGAA
AATTAAGAAGCTGACTTTATATTTGGTGGTTTGAAGTATCTTGTTGTTAGCATTTGTAATAATGCTAAAAAAGGCCTAATAAAATGCCCA
AGAAAATATTCAGTGCATTTATAGAGAAGGATATTTTGTAGTAGTATAGTAATGTGTTATGTAGTACAGTTTTAAAGCTATAAATGGAAT
TTTGTGTAAATTCACAAAAATGTGATATAAACAGGATCTAAGACTGGATTCCCTGTCACTAAACTGCACCACTATACCTGTCTCTCTGTG
TGGGGGACACTGCTGATGATTCCCAAGATTGAGATGATGACGGTGATGACGACTGGGTGAACAGCCATCACTTCAACATTGTGATAATCC
TTCACAGCAAGAAACCGAATAAAATACTAACATTTCTAACAACTGCTCTGACATTGTAAAGAGATCCAACAGAATCACTCCTGCTGAAAA
ATACGCTTTCTGCCACCTACACATTTCTATTTAGGAAGTAAAATTTGCTTCATGGTCATGACCCCATTAGTCAGTGTTACAGCTGTGTTG
GGGATAGGAAGTATATCTGGCAGATTGATATTTATACACTTTTTTATAAAGCAGATTTTAAAATATAGTAACATCCATTTTTTTCCCTTG
AAAGTGATTCTCTTATAAAAAATGAAAGTGGAGTTTAAGGTATATCAAATCGTTGTGGAAGGTGATTAAAAATCAAAATTCTTTTAAATA
TCAACTTAATTTTTTCTAAGTAAGATACAAAAAATTTTCATCTAAAGTAATATTTCACTTTATATTGTAAAGAAGGTAGGTATATTGGTG
GCTGAGGTCTCTTGAAATTGCTAAAGGGAAATTTTTCTATGGTAATGCTCTTACGGATATAAACCTCAGTTAAATGGAATTATCTATGGG
ATGTGTGGTTCTGGTTAACTAAAAATTAACCAGTAAACACTCTGTAGTAACCATTACAGAAAATACTTCTGCCTTAAAAAATATGATATG
CCAGAGATGAGTTAGTGTTTCTTGACGTTGGAGACCTTTTAAATGCCTCATCTGTTGTACTGAACAATTGAAACTGCATGCAGCCATAAA
AGGGACAAGAAACAGAACTGTTTACTAACTTTGGGACATCCCCTGGAGTTTTTAAAAATAAATAAATATATATATATATAAAAAAAAC

>29631_29631_1_FBXL20-BTBD1_FBXL20_chr17_37499433_ENST00000264658_BTBD1_chr15_83725297_ENST00000261721_length(amino acids)=383AA_BP=26
MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARL
FDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPL
MTIEEFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRISIVGFGLYGS
IHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPNVCYTACATLKGPDSHYGTKGLKKVVHETPAASKTVFFFF
SSPGNNNGTSIEDGQIPEIIFYT

--------------------------------------------------------------
>29631_29631_2_FBXL20-BTBD1_FBXL20_chr17_37499433_ENST00000394294_BTBD1_chr15_83725297_ENST00000261721_length(transcript)=3018nt_BP=325nt
GAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGAGGTGGTGGAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTC
CCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGGAACTCCCGGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCC
GCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGGGACGTGAACGGAGTGACCAAGAGCAGGTTTGAGATGTTCT
CAAATAGTGATGAAGCTGTAATCAATAAAAAACTTCCCAAAGAACTCCTGTTACGATTTCTATATTCAGATGAAGTTCAAATTGGTCCAG
AAACAGTTATGACCACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCAAACATCTTA
GGGCAGATAATGCCTTTATGTTACTTACTCAGGCTCGATTATTTGATGAACCTCAGCTTGCTAGTCTTTGTCTAGATACAATAGACAAAA
GCACAATGGATGCAATAAGTGCAGAAGGGTTTACTGATATTGATATAGATACACTCTGTGCAGTTTTAGAGAGAGACACACTCAGTATTC
GAGAAAGTCGACTTTTTGGAGCTGTTGTACGCTGGGCAGAAGCAGAATGTCAGAGACAACAATTACCTGTGACTTTTGGGAATAAACAAA
AAGTTCTAGGAAAAGCACTTTCCTTAATCCGGTTCCCACTGATGACAATTGAGGAATTTGCAGCAGGTCCTGCTCAATCTGGAATTTTGT
CAGATCGTGAAGTGGTAAACCTCTTTCTTCATTTTACTGTCAACCCTAAACCCCGAGTTGAATACATTGACCGACCAAGATGCTGTCTCA
GGGGAAAGGAATGCTGCATCAATAGATTCCAGCAAGTAGAAAGCCGCTGGGGTTACAGTGGGACGAGTGATCGAATCAGATTCACAGTTA
ATAGAAGGATCTCTATAGTTGGATTTGGCTTGTATGGATCTATTCATGGCCCTACAGATTATCAAGTGAATATACAGATCATTGAATATG
AGAAAAAGCAAACCCTGGGACAGAATGATACCGGCTTTAGTTGTGATGGGACAGCTAACACATTCAGGGTCATGTTCAAGGAACCCATAG
AGATCCTGCCCAATGTGTGCTACACAGCATGTGCAACACTCAAAGGTCCAGATTCCCACTATGGCACAAAAGGATTGAAGAAAGTAGTGC
ATGAGACACCTGCTGCAAGCAAGACTGTTTTTTTCTTTTTTAGTTCCCCTGGCAATAATAATGGCACTTCAATAGAAGATGGACAAATTC
CAGAAATCATATTTTATACATAATTTAGCATTATAATACATCTTGGCTAAATAATACCATACAATCTAGTGTCAAAAACATAAATGGCCA
CAAAAAAGTAGTTTGAGTGTTATGAATATTTAAAATTGTAAGATAAGAAACAGTTTCTTAGAGCAGATAGAAAAATGCTTATTTAAATCT
TTGCATGATTTAAAAACAGATTTTCCATTTTCTTACAACTTTAAGAGAAAAGAACTGGGTTTAATGGTTTAAAAAAAAGCACAGCTTTTT
CACCTTCATCTTGTATAATTTCATAGATTGGCTGACTTAGGGTCTTTCAATAGTTTGGGAATTGAAAGATTCTTGTTATATATAGCTAGT
TTGGGTTTGTTTTTGTTTTAACTATTTTGAAGGTTAGGTGAGATGGGCAAATAGGCTTAACTATTTTGAAGGTTGGATGAAAAGAGATGG
GTCAGTATTCCTACAGAATTCTTATTAACTCAAATAACTAAATTTCAGAAAATTAAGAAGCTGACTTTATATTTGGTGGTTTGAAGTATC
TTGTTGTTAGCATTTGTAATAATGCTAAAAAAGGCCTAATAAAATGCCCAAGAAAATATTCAGTGCATTTATAGAGAAGGATATTTTGTA
GTAGTATAGTAATGTGTTATGTAGTACAGTTTTAAAGCTATAAATGGAATTTTGTGTAAATTCACAAAAATGTGATATAAACAGGATCTA
AGACTGGATTCCCTGTCACTAAACTGCACCACTATACCTGTCTCTCTGTGTGGGGGACACTGCTGATGATTCCCAAGATTGAGATGATGA
CGGTGATGACGACTGGGTGAACAGCCATCACTTCAACATTGTGATAATCCTTCACAGCAAGAAACCGAATAAAATACTAACATTTCTAAC
AACTGCTCTGACATTGTAAAGAGATCCAACAGAATCACTCCTGCTGAAAAATACGCTTTCTGCCACCTACACATTTCTATTTAGGAAGTA
AAATTTGCTTCATGGTCATGACCCCATTAGTCAGTGTTACAGCTGTGTTGGGGATAGGAAGTATATCTGGCAGATTGATATTTATACACT
TTTTTATAAAGCAGATTTTAAAATATAGTAACATCCATTTTTTTCCCTTGAAAGTGATTCTCTTATAAAAAATGAAAGTGGAGTTTAAGG
TATATCAAATCGTTGTGGAAGGTGATTAAAAATCAAAATTCTTTTAAATATCAACTTAATTTTTTCTAAGTAAGATACAAAAAATTTTCA
TCTAAAGTAATATTTCACTTTATATTGTAAAGAAGGTAGGTATATTGGTGGCTGAGGTCTCTTGAAATTGCTAAAGGGAAATTTTTCTAT
GGTAATGCTCTTACGGATATAAACCTCAGTTAAATGGAATTATCTATGGGATGTGTGGTTCTGGTTAACTAAAAATTAACCAGTAAACAC
TCTGTAGTAACCATTACAGAAAATACTTCTGCCTTAAAAAATATGATATGCCAGAGATGAGTTAGTGTTTCTTGACGTTGGAGACCTTTT
AAATGCCTCATCTGTTGTACTGAACAATTGAAACTGCATGCAGCCATAAAAGGGACAAGAAACAGAACTGTTTACTAACTTTGGGACATC
CCCTGGAGTTTTTAAAAATAAATAAATATATATATATATAAAAAAAAC

>29631_29631_2_FBXL20-BTBD1_FBXL20_chr17_37499433_ENST00000394294_BTBD1_chr15_83725297_ENST00000261721_length(amino acids)=383AA_BP=26
MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARL
FDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPL
MTIEEFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRISIVGFGLYGS
IHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPNVCYTACATLKGPDSHYGTKGLKKVVHETPAASKTVFFFF
SSPGNNNGTSIEDGQIPEIIFYT

--------------------------------------------------------------
>29631_29631_3_FBXL20-BTBD1_FBXL20_chr17_37499433_ENST00000577399_BTBD1_chr15_83725297_ENST00000261721_length(transcript)=3106nt_BP=413nt
GCCAAAGGAAGGGTTGCCCGGCTCCAGCCCTGCACCCCCGACCCCCGGCCTCAGGTGCAGCTCCGCAGCCATCCCCGGACCAGGGCGGGC
ACTTGGCCTGTTGCTCAGCGCAACCACCCTCGCCCTCCCGAGCCATGCACAGGGAGACAAGCGTCCGGCCCCGGCCCCCCAGGCCTCCCT
GCAGCACCCCGTAATGTAATGCACTGGGGCGGGGGAGGCGGGGGAGGCGGCGGCGGCGGCAACCGCGGAGGCGCGGCGGCAGCCGCACTG
CCCCAATCTAGACACATCCAGAAGAGGAGGAAAATGGCTCCGAGCAGGGACCGCCTGCTGCACTTTGGGTTCAAGGCGACAATGTTCTCA
AATAGTGATGAAGCTGTAATCAATAAAAAACTTCCCAAAGAACTCCTGTTACGATTTCTATATTCAGATGAAGTTCAAATTGGTCCAGAA
ACAGTTATGACCACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCAAACATCTTAGG
GCAGATAATGCCTTTATGTTACTTACTCAGGCTCGATTATTTGATGAACCTCAGCTTGCTAGTCTTTGTCTAGATACAATAGACAAAAGC
ACAATGGATGCAATAAGTGCAGAAGGGTTTACTGATATTGATATAGATACACTCTGTGCAGTTTTAGAGAGAGACACACTCAGTATTCGA
GAAAGTCGACTTTTTGGAGCTGTTGTACGCTGGGCAGAAGCAGAATGTCAGAGACAACAATTACCTGTGACTTTTGGGAATAAACAAAAA
GTTCTAGGAAAAGCACTTTCCTTAATCCGGTTCCCACTGATGACAATTGAGGAATTTGCAGCAGGTCCTGCTCAATCTGGAATTTTGTCA
GATCGTGAAGTGGTAAACCTCTTTCTTCATTTTACTGTCAACCCTAAACCCCGAGTTGAATACATTGACCGACCAAGATGCTGTCTCAGG
GGAAAGGAATGCTGCATCAATAGATTCCAGCAAGTAGAAAGCCGCTGGGGTTACAGTGGGACGAGTGATCGAATCAGATTCACAGTTAAT
AGAAGGATCTCTATAGTTGGATTTGGCTTGTATGGATCTATTCATGGCCCTACAGATTATCAAGTGAATATACAGATCATTGAATATGAG
AAAAAGCAAACCCTGGGACAGAATGATACCGGCTTTAGTTGTGATGGGACAGCTAACACATTCAGGGTCATGTTCAAGGAACCCATAGAG
ATCCTGCCCAATGTGTGCTACACAGCATGTGCAACACTCAAAGGTCCAGATTCCCACTATGGCACAAAAGGATTGAAGAAAGTAGTGCAT
GAGACACCTGCTGCAAGCAAGACTGTTTTTTTCTTTTTTAGTTCCCCTGGCAATAATAATGGCACTTCAATAGAAGATGGACAAATTCCA
GAAATCATATTTTATACATAATTTAGCATTATAATACATCTTGGCTAAATAATACCATACAATCTAGTGTCAAAAACATAAATGGCCACA
AAAAAGTAGTTTGAGTGTTATGAATATTTAAAATTGTAAGATAAGAAACAGTTTCTTAGAGCAGATAGAAAAATGCTTATTTAAATCTTT
GCATGATTTAAAAACAGATTTTCCATTTTCTTACAACTTTAAGAGAAAAGAACTGGGTTTAATGGTTTAAAAAAAAGCACAGCTTTTTCA
CCTTCATCTTGTATAATTTCATAGATTGGCTGACTTAGGGTCTTTCAATAGTTTGGGAATTGAAAGATTCTTGTTATATATAGCTAGTTT
GGGTTTGTTTTTGTTTTAACTATTTTGAAGGTTAGGTGAGATGGGCAAATAGGCTTAACTATTTTGAAGGTTGGATGAAAAGAGATGGGT
CAGTATTCCTACAGAATTCTTATTAACTCAAATAACTAAATTTCAGAAAATTAAGAAGCTGACTTTATATTTGGTGGTTTGAAGTATCTT
GTTGTTAGCATTTGTAATAATGCTAAAAAAGGCCTAATAAAATGCCCAAGAAAATATTCAGTGCATTTATAGAGAAGGATATTTTGTAGT
AGTATAGTAATGTGTTATGTAGTACAGTTTTAAAGCTATAAATGGAATTTTGTGTAAATTCACAAAAATGTGATATAAACAGGATCTAAG
ACTGGATTCCCTGTCACTAAACTGCACCACTATACCTGTCTCTCTGTGTGGGGGACACTGCTGATGATTCCCAAGATTGAGATGATGACG
GTGATGACGACTGGGTGAACAGCCATCACTTCAACATTGTGATAATCCTTCACAGCAAGAAACCGAATAAAATACTAACATTTCTAACAA
CTGCTCTGACATTGTAAAGAGATCCAACAGAATCACTCCTGCTGAAAAATACGCTTTCTGCCACCTACACATTTCTATTTAGGAAGTAAA
ATTTGCTTCATGGTCATGACCCCATTAGTCAGTGTTACAGCTGTGTTGGGGATAGGAAGTATATCTGGCAGATTGATATTTATACACTTT
TTTATAAAGCAGATTTTAAAATATAGTAACATCCATTTTTTTCCCTTGAAAGTGATTCTCTTATAAAAAATGAAAGTGGAGTTTAAGGTA
TATCAAATCGTTGTGGAAGGTGATTAAAAATCAAAATTCTTTTAAATATCAACTTAATTTTTTCTAAGTAAGATACAAAAAATTTTCATC
TAAAGTAATATTTCACTTTATATTGTAAAGAAGGTAGGTATATTGGTGGCTGAGGTCTCTTGAAATTGCTAAAGGGAAATTTTTCTATGG
TAATGCTCTTACGGATATAAACCTCAGTTAAATGGAATTATCTATGGGATGTGTGGTTCTGGTTAACTAAAAATTAACCAGTAAACACTC
TGTAGTAACCATTACAGAAAATACTTCTGCCTTAAAAAATATGATATGCCAGAGATGAGTTAGTGTTTCTTGACGTTGGAGACCTTTTAA
ATGCCTCATCTGTTGTACTGAACAATTGAAACTGCATGCAGCCATAAAAGGGACAAGAAACAGAACTGTTTACTAACTTTGGGACATCCC
CTGGAGTTTTTAAAAATAAATAAATATATATATATATAAAAAAAAC

>29631_29631_3_FBXL20-BTBD1_FBXL20_chr17_37499433_ENST00000577399_BTBD1_chr15_83725297_ENST00000261721_length(amino acids)=420AA_BP=4
MHWGGGGGGGGGGGNRGGAAAAALPQSRHIQKRRKMAPSRDRLLHFGFKATMFSNSDEAVINKKLPKELLLRFLYSDEVQIGPETVMTTL
YTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFG
AVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCI
NRFQQVESRWGYSGTSDRIRFTVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPNVC
YTACATLKGPDSHYGTKGLKKVVHETPAASKTVFFFFSSPGNNNGTSIEDGQIPEIIFYT

--------------------------------------------------------------
>29631_29631_4_FBXL20-BTBD1_FBXL20_chr17_37499433_ENST00000583610_BTBD1_chr15_83725297_ENST00000379403_length(transcript)=1424nt_BP=358nt
GTTTTTGTTTTGGGTTGAAGTTGAGGCTGAGGAGAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGAGGTGGTG
GAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTCCCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGGAACTCCC
GGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCCGCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGGGACGTGA
ACGGAGTGACCAAGAGCAGGTTTGAGATGTTCTCAAATAGTGATGAAGCTGTAATCAATAAAAAACTTCCCAAAGAACTCCTGTTACGAT
TTCTATATTCAGATGAAGTTCAAATTGGTCCAGAAACAGTTATGACCACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAG
CACACTGTGTAGAATTTCTCACCAAACATCTTAGGGCAGATAATGCCTTTATGTTACTTACTCAGGCTCGATTATTTGATGAACCTCAGC
TTGCTAGTCTTTGTCTAGATACAATAGACAAAAGCACAATGGATGCAATAAGTGCAGAAGGGTTTACTGATATTGATATAGATACACTCT
GTGCAGTTTTAGAGAGAGACACACTCAGTATTCGAGAAAGTCGACTTTTTGGAGCTGTTGTACGCTGGGCAGAAGCAGAATGTCAGAGAC
AACAATTACCTGTGACTTTTGGGAATAAACAAAAAGTTCTAGGAAAAGCACTTTCCTTAATCCGGTTCCCACTGATGACAATTGAGGAAT
TTGCAGCAGGTCCTGCTCAATCTGGAATTTTGTCAGATCGTGAAGTGGTAAACCTCTTTCTTCATTTTACTGTCAACCCTAAACCCCGAG
TTGAATACATTGACCGACCAAGATGCTGTCTCAGGGGAAAGGAATGCTGCATCAATAGATTCCAGCAAGTAGAAAGCCGCTGGGGTTACA
GTGGGACGAGTGATCGAATCAGATCATTGAATATGAGAAAAAGCAAACCCTGGGACAGAATGATACCGGCTTTAGTTGTGATGGGACAGC
TAACACATTCAGGGTCATGTTCAAGGAACCCATAGAGATCCTGCCCAATGTGTGCTACACAGCATGTGCAACACTCAAAGGTCCAGATTC
CCACTATGGCACAAAAGGATTGAAGAAAGTAGTGCATGAGACACCTGCTGCAAGCAAGACTGTTTTTTTCTTTTTTAGTTCCCCTGGCAA
TAATAATGGCACTTCAATAGAAGATGGACAAATTCCAGAAATCATATTTTATACATAATTTAGCATTATAATACATCTTGGCTAAATAAT
ACCATACAATCTAGTGTCAAAAACATAAATGGCCACAAAAAAGTAGTTTGAGTGTTATGAATATTTAAAATTGT

>29631_29631_4_FBXL20-BTBD1_FBXL20_chr17_37499433_ENST00000583610_BTBD1_chr15_83725297_ENST00000379403_length(amino acids)=286AA_BP=26
MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARL
FDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPL
MTIEEFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRSLNMRKSKPWDRMIPAL
VVMGQLTHSGSCSRNP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FBXL20-BTBD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXL20-BTBD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXL20-BTBD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0520757Delayed Emergence from Anesthesia1CTD_human
TgeneC4042763Postoperative Residual Curarization1CTD_human