Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:FRMD5-ALDH1A3 (FusionGDB2 ID:HG84978TG220)

Fusion Gene Summary for FRMD5-ALDH1A3

check button Fusion gene summary
Fusion gene informationFusion gene name: FRMD5-ALDH1A3
Fusion gene ID: hg84978tg220
HgeneTgene
Gene symbol

FRMD5

ALDH1A3

Gene ID

84978

220

Gene nameFERM domain containing 5aldehyde dehydrogenase 1 family member A3
Synonyms-ALDH1A6|ALDH6|MCOP8|RALDH3
Cytomap('FRMD5')('ALDH1A3')

15q15.3

15q26.3

Type of geneprotein-codingprotein-coding
DescriptionFERM domain-containing protein 5aldehyde dehydrogenase family 1 member A3acetaldehyde dehydrogenase 6aldehyde dehydrogenase 6retinaldehyde dehydrogenase 3
Modification date2020031320200322
UniProtAcc

Q7Z6J6

.
Ensembl transtripts involved in fusion geneENST00000402883, ENST00000417257, 
ENST00000484674, 
Fusion gene scores* DoF score12 X 11 X 5=6603 X 3 X 3=27
# samples 143
** MAII scorelog2(14/660*10)=-2.23703919730085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FRMD5 [Title/Abstract] AND ALDH1A3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFRMD5(44487151)-ALDH1A3(101425472), # samples:1
Anticipated loss of major functional domain due to fusion event.FRMD5-ALDH1A3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FRMD5-ALDH1A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneALDH1A3

GO:0002138

retinoic acid biosynthetic process

27759097

TgeneALDH1A3

GO:0042573

retinoic acid metabolic process

11585737

TgeneALDH1A3

GO:0042574

retinal metabolic process

11585737

TgeneALDH1A3

GO:0051289

protein homotetramerization

27759097


check buttonFusion gene breakpoints across FRMD5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ALDH1A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A486-01AFRMD5chr15

44487151

-ALDH1A3chr15

101425472

+


Top

Fusion Gene ORF analysis for FRMD5-ALDH1A3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000402883ENST00000560555FRMD5chr15

44487151

-ALDH1A3chr15

101425472

+
5CDS-3UTRENST00000417257ENST00000560555FRMD5chr15

44487151

-ALDH1A3chr15

101425472

+
5CDS-intronENST00000402883ENST00000557963FRMD5chr15

44487151

-ALDH1A3chr15

101425472

+
5CDS-intronENST00000417257ENST00000557963FRMD5chr15

44487151

-ALDH1A3chr15

101425472

+
In-frameENST00000402883ENST00000329841FRMD5chr15

44487151

-ALDH1A3chr15

101425472

+
In-frameENST00000402883ENST00000346623FRMD5chr15

44487151

-ALDH1A3chr15

101425472

+
In-frameENST00000417257ENST00000329841FRMD5chr15

44487151

-ALDH1A3chr15

101425472

+
In-frameENST00000417257ENST00000346623FRMD5chr15

44487151

-ALDH1A3chr15

101425472

+
intron-3CDSENST00000484674ENST00000329841FRMD5chr15

44487151

-ALDH1A3chr15

101425472

+
intron-3CDSENST00000484674ENST00000346623FRMD5chr15

44487151

-ALDH1A3chr15

101425472

+
intron-3UTRENST00000484674ENST00000560555FRMD5chr15

44487151

-ALDH1A3chr15

101425472

+
intron-intronENST00000484674ENST00000557963FRMD5chr15

44487151

-ALDH1A3chr15

101425472

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000417257FRMD5chr1544487151-ENST00000329841ALDH1A3chr15101425472+3572279871718543
ENST00000417257FRMD5chr1544487151-ENST00000346623ALDH1A3chr15101425472+3251279871397436
ENST00000402883FRMD5chr1544487151-ENST00000329841ALDH1A3chr15101425472+3551258661697543
ENST00000402883FRMD5chr1544487151-ENST00000346623ALDH1A3chr15101425472+3230258661376436

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000417257ENST00000329841FRMD5chr1544487151-ALDH1A3chr15101425472+0.0003964570.99960357
ENST00000417257ENST00000346623FRMD5chr1544487151-ALDH1A3chr15101425472+0.0002373260.9997627
ENST00000402883ENST00000329841FRMD5chr1544487151-ALDH1A3chr15101425472+0.0003953170.99960476
ENST00000402883ENST00000346623FRMD5chr1544487151-ALDH1A3chr15101425472+0.0002366280.9997634

Top

Fusion Genomic Features for FRMD5-ALDH1A3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FRMD5chr1544487150-ALDH1A3chr15101425471+0.0014103910.9985896
FRMD5chr1544487150-ALDH1A3chr15101425471+0.0014103910.9985896

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for FRMD5-ALDH1A3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:44487151/chr15:101425472)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRMD5

Q7Z6J6

.
FUNCTION: May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneALDH1A3chr15:44487151chr15:101425472ENST00000329841013257_26233513.0Nucleotide bindingNAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFRMD5chr15:44487151chr15:101425472ENST00000417257-11417_29834571.0DomainFERM
HgeneFRMD5chr15:44487151chr15:101425472ENST00000417257-114504_52434571.0TransmembraneHelical


Top

Fusion Gene Sequence for FRMD5-ALDH1A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31352_31352_1_FRMD5-ALDH1A3_FRMD5_chr15_44487151_ENST00000402883_ALDH1A3_chr15_101425472_ENST00000329841_length(transcript)=3551nt_BP=258nt
AAGGAGGAGGAACGAGGCCAGCAGGAGGCAACGGCAGCGACGGGGCCGGGGTGATGGTGCAGGTGCCTGGGGTCGGTGCGGAGCTGCCGG
GCTGAGGGACGCCTGGTCCAGGGTCCGCAGCGCCGCCGCGTCGCTCCCGGGCGGGCGGGCGGGAAGATGCTGAGCAGGTTGATGAGCGGC
AGCAGCAGGAGCCTGGAGCGCGAGTACAGCTGCACCGTGCGGCTGCTGGACGACAGCGAGTACACCTGCACCATCCAGATATTTATCAAC
AATGAATGGCACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATATGTGAAGTGGAAGAAGGAGAT
AAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTTGCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGG
CGGCTGCTGCACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATGGATACAGGGAAGCCATTTCTT
CATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACCCTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCC
ACAGATGACAACGTCGTGTGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGGAACTTCCCCCTGCTGATGCTG
GTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACCATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGC
TCTCTGATCAAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTGGGAGCAGCAATTTCTTCTCAC
CCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAGGTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTG
ACGCTGGAGCTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAGTGTGCCCATCAGGGAGTGTTC
TTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTGTTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTAT
GCCAAGAAACGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAGCAGTTCGACAAAATCTTAGAG
CTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAATGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTC
TTCTCAGAAGTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTGAAGTTCAAAAGTATCGAAGAA
GTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACAGCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCC
TTAGAGTCTGGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTTAAAATGTCAGGAAATGGCAGA
GAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTGAAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGAAGGAAAGGCGGG
GCTCCTTCCTCAAACATCGGACGGCGGAATGTGGCAGATGAAATGTGCTGGAGGAAAAAAATGACATTTCTGACCTTCCCGGGACACATT
CTTCTGGAGGCTTTACATCTACTGGAGTTGAATGATTGCTGTTTTCCTCTCACTCTCCTGTTTATTCACCAGACTGGGGATGCCTATAGG
TTGTCTGTGAAATCGCAGTCCTGCCTGGGGAGGGAGCTGTTGGCCATTTCTGTGTTTCCCTTTAAACCAGATCCTGGAGACAGTGAGATA
CTCAGGGCGTTGTTAACAGGGAGTGGTATTTGAAGTGTCCAGCAGTTGCTTGAAATGCTTTGCCGAATCTGACTCCAGTAAGAATGTGGG
AAAACCCCCTGTGTGTTCTGCAAGCAGGGCTCTTGCACCAGCGGTCTCCTCAGGGTGGACCTGCTTACAGAGCAAGCCACGCCTCTTTCC
GAGGTGAAGGTGGGACCATTCCTTGGGAAAGGATTCACAGTAAGGTTTTTTGGTTTTTGTTTTTTGTTTTCTTGTTTTTAAAAAAAGGAT
TTCACAGTGAGAAAGTTTTGGTTAGTGCATACCGTGGAAGGGCGCCAGGGTCTTTGTGGATTGCATGTTGACATTGACCGTGAGATTCGG
CTTCAAACCAATACTGCCTTTGGAATATGACAGAATCAATAGCCCAGAGAGCTTAGTCAAAGACGATATCACGGTCTACCTTAACCAAGG
CACTTTCTTAAGCAGAAAATATTGTTGAGGTTACCTTTGCTGCTAAAGATCCAATCTTCTAACGCCACAACAGCATAGCAAATCCTAGGA
TAATTCACCTCCTCATTTGACAAATCAGAGCTGTAATTCGCTTTAACAAATTACGCATTTCTATCACGTTCACTAACAGCTTATGATAAG
TCTGTGTAGTCTTCCTTTTCTCCAGTTCTGTTACCCAATTTAGATTAGTAAAGCGTACACAACTGGAAAGACTGCTGTAATAACACAGCC
TTGTTATTTTTAAGTCCTATTTTGATATTAATTTCTGATTAGTTAGTAAATAACACCTGGATTCTATGGAGGACCTCGGTCTTCATCCAA
GTGGCCTGAGTATTTCACTGGCAGGTTGTGAATTTTTCTTTTCCTCTTTGGGGATCCAAATGATGATGTGCAATTTCATGTTTTAACTTG
GGAAACTGAAAGTGTTCCCATATAGCTTCAAAAACAAAAACAAATGTGTTATCCGACGGATACTTTTATGGTTACTAACTAGTACTTTCC
TAATTGGGAAAGTAGTGCTTAAGTTTGCAAATTAAGTTGGGGAGGGCAATAATAAAATGAGGGCCCGTAACAGAACCAGTGTGTGTATAA
CGAAAACCATGTATAAAATGGGCCTATCACCCTTGTCAGAGATATAAATTACCACATTTGCCTTCCCTTCATCAGCTAACACTTATCACT
TATACTACCAATAACTTGTTAAATCAGGATTTGGCTTCATACACTGAATTTTCAGTATTTTATCTCAAGTAGATATAGACACTAACCTTG
ATAGTGATACGTTAGAGGGTTCCTATTCTTCCATTGTACGATAATGTCTTTAATATGAAATGCTACATTATTTATAATTGGTAGAGTTAT
TGTATCTTTTTATAGTTGTAAGTACACAGAGGTGGTATATTTAAACTTCTGTAATATACTGTATTTAGAAATGGAAATATATATAGTGTT
AGGTTTCACTTCTTTTAAGGTTTACCCCTGTGGTGTGGTTTAAAAATCTATAGGCCTGGGAATTCCGATCCTAGCTGCAGATCGCATCCC

>31352_31352_1_FRMD5-ALDH1A3_FRMD5_chr15_44487151_ENST00000402883_ALDH1A3_chr15_101425472_ENST00000329841_length(amino acids)=543AA_BP=64
MGSVRSCRAEGRLVQGPQRRRVAPGRAGGKMLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQIFINNEWHESKSGKKFATCNPSTREQ
ICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWAD
KIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPT
VGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSE
FVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPI
LKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGD

--------------------------------------------------------------
>31352_31352_2_FRMD5-ALDH1A3_FRMD5_chr15_44487151_ENST00000402883_ALDH1A3_chr15_101425472_ENST00000346623_length(transcript)=3230nt_BP=258nt
AAGGAGGAGGAACGAGGCCAGCAGGAGGCAACGGCAGCGACGGGGCCGGGGTGATGGTGCAGGTGCCTGGGGTCGGTGCGGAGCTGCCGG
GCTGAGGGACGCCTGGTCCAGGGTCCGCAGCGCCGCCGCGTCGCTCCCGGGCGGGCGGGCGGGAAGATGCTGAGCAGGTTGATGAGCGGC
AGCAGCAGGAGCCTGGAGCGCGAGTACAGCTGCACCGTGCGGCTGCTGGACGACAGCGAGTACACCTGCACCATCCAGATATTTATCAAC
AATGAATGGCACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATATGTGAAGTGGAAGAAGGAGAT
AAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTTGCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGG
CGGCTGCTGCACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCA
GGATTCGGGCCCACAGTGGGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAGGTTGGAAAACTG
GTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAGCTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGAC
TTGGACTTGGCAGTGGAGTGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTGTTCGTGGAGGAG
CAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAACGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGG
CCTCAGATTGATCAAAAGCAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAATGCGGGGGCTCA
GCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAAGTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGG
CCAGTGCAACCAATACTGAAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACAGCAGCCGTGTTC
ACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCTGGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAG
GCTCCATTTGGTGGCTTTAAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTGAAAACTGTCACC
ATCAAACTTGGCGACAAGAACCCCTGAAGGAAAGGCGGGGCTCCTTCCTCAAACATCGGACGGCGGAATGTGGCAGATGAAATGTGCTGG
AGGAAAAAAATGACATTTCTGACCTTCCCGGGACACATTCTTCTGGAGGCTTTACATCTACTGGAGTTGAATGATTGCTGTTTTCCTCTC
ACTCTCCTGTTTATTCACCAGACTGGGGATGCCTATAGGTTGTCTGTGAAATCGCAGTCCTGCCTGGGGAGGGAGCTGTTGGCCATTTCT
GTGTTTCCCTTTAAACCAGATCCTGGAGACAGTGAGATACTCAGGGCGTTGTTAACAGGGAGTGGTATTTGAAGTGTCCAGCAGTTGCTT
GAAATGCTTTGCCGAATCTGACTCCAGTAAGAATGTGGGAAAACCCCCTGTGTGTTCTGCAAGCAGGGCTCTTGCACCAGCGGTCTCCTC
AGGGTGGACCTGCTTACAGAGCAAGCCACGCCTCTTTCCGAGGTGAAGGTGGGACCATTCCTTGGGAAAGGATTCACAGTAAGGTTTTTT
GGTTTTTGTTTTTTGTTTTCTTGTTTTTAAAAAAAGGATTTCACAGTGAGAAAGTTTTGGTTAGTGCATACCGTGGAAGGGCGCCAGGGT
CTTTGTGGATTGCATGTTGACATTGACCGTGAGATTCGGCTTCAAACCAATACTGCCTTTGGAATATGACAGAATCAATAGCCCAGAGAG
CTTAGTCAAAGACGATATCACGGTCTACCTTAACCAAGGCACTTTCTTAAGCAGAAAATATTGTTGAGGTTACCTTTGCTGCTAAAGATC
CAATCTTCTAACGCCACAACAGCATAGCAAATCCTAGGATAATTCACCTCCTCATTTGACAAATCAGAGCTGTAATTCGCTTTAACAAAT
TACGCATTTCTATCACGTTCACTAACAGCTTATGATAAGTCTGTGTAGTCTTCCTTTTCTCCAGTTCTGTTACCCAATTTAGATTAGTAA
AGCGTACACAACTGGAAAGACTGCTGTAATAACACAGCCTTGTTATTTTTAAGTCCTATTTTGATATTAATTTCTGATTAGTTAGTAAAT
AACACCTGGATTCTATGGAGGACCTCGGTCTTCATCCAAGTGGCCTGAGTATTTCACTGGCAGGTTGTGAATTTTTCTTTTCCTCTTTGG
GGATCCAAATGATGATGTGCAATTTCATGTTTTAACTTGGGAAACTGAAAGTGTTCCCATATAGCTTCAAAAACAAAAACAAATGTGTTA
TCCGACGGATACTTTTATGGTTACTAACTAGTACTTTCCTAATTGGGAAAGTAGTGCTTAAGTTTGCAAATTAAGTTGGGGAGGGCAATA
ATAAAATGAGGGCCCGTAACAGAACCAGTGTGTGTATAACGAAAACCATGTATAAAATGGGCCTATCACCCTTGTCAGAGATATAAATTA
CCACATTTGCCTTCCCTTCATCAGCTAACACTTATCACTTATACTACCAATAACTTGTTAAATCAGGATTTGGCTTCATACACTGAATTT
TCAGTATTTTATCTCAAGTAGATATAGACACTAACCTTGATAGTGATACGTTAGAGGGTTCCTATTCTTCCATTGTACGATAATGTCTTT
AATATGAAATGCTACATTATTTATAATTGGTAGAGTTATTGTATCTTTTTATAGTTGTAAGTACACAGAGGTGGTATATTTAAACTTCTG
TAATATACTGTATTTAGAAATGGAAATATATATAGTGTTAGGTTTCACTTCTTTTAAGGTTTACCCCTGTGGTGTGGTTTAAAAATCTAT

>31352_31352_2_FRMD5-ALDH1A3_FRMD5_chr15_44487151_ENST00000402883_ALDH1A3_chr15_101425472_ENST00000346623_length(amino acids)=436AA_BP=64
MGSVRSCRAEGRLVQGPQRRRVAPGRAGGKMLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQIFINNEWHESKSGKKFATCNPSTREQ
ICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFT
GSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDP
FDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTD

--------------------------------------------------------------
>31352_31352_3_FRMD5-ALDH1A3_FRMD5_chr15_44487151_ENST00000417257_ALDH1A3_chr15_101425472_ENST00000329841_length(transcript)=3572nt_BP=279nt
GGCTGAGGGAAGGAGGAGGATAAGGAGGAGGAACGAGGCCAGCAGGAGGCAACGGCAGCGACGGGGCCGGGGTGATGGTGCAGGTGCCTG
GGGTCGGTGCGGAGCTGCCGGGCTGAGGGACGCCTGGTCCAGGGTCCGCAGCGCCGCCGCGTCGCTCCCGGGCGGGCGGGCGGGAAGATG
CTGAGCAGGTTGATGAGCGGCAGCAGCAGGAGCCTGGAGCGCGAGTACAGCTGCACCGTGCGGCTGCTGGACGACAGCGAGTACACCTGC
ACCATCCAGATATTTATCAACAATGAATGGCACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTTGCCTTCCAGAGGGGCTCGCCATGGCGCCGG
CTGGATGCCCTGAGTCGTGGGCGGCTGCTGCACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATG
GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACCCTCAGATACTTTGCAGGGTGGGCAGACAAA
ATCCAGGGCAAGACCATCCCCACAGATGACAACGTCGTGTGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGG
AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACCATGGTCCTGAAGCCTGCGGAGCAGACACCT
CTCACCGCCCTTTATCTCGGCTCTCTGATCAAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG
GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAGGTTGGAAAACTGGTTAAAGAAGCTGCGTCC
CGGAGCAATCTGAAGCGGGTGACGCTGGAGCTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAG
TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTGTTCGTGGAGGAGCAGGTCTACTCTGAGTTT
GTCAGGCGGAGCGTGGAGTATGCCAAGAAACGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAG
CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAATGCGGGGGCTCAGCCATGGAAGACAAGGGG
CTCTTCATCAAACCCACTGTCTTCTCAGAAGTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTG
AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACAGCAGCCGTGTTCACAAAAAATCTCGACAAA
GCCCTGAAGTTGGCTTCTGCCTTAGAGTCTGGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT
AAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTGAAAACTGTCACCATCAAACTTGGCGACAAG
AACCCCTGAAGGAAAGGCGGGGCTCCTTCCTCAAACATCGGACGGCGGAATGTGGCAGATGAAATGTGCTGGAGGAAAAAAATGACATTT
CTGACCTTCCCGGGACACATTCTTCTGGAGGCTTTACATCTACTGGAGTTGAATGATTGCTGTTTTCCTCTCACTCTCCTGTTTATTCAC
CAGACTGGGGATGCCTATAGGTTGTCTGTGAAATCGCAGTCCTGCCTGGGGAGGGAGCTGTTGGCCATTTCTGTGTTTCCCTTTAAACCA
GATCCTGGAGACAGTGAGATACTCAGGGCGTTGTTAACAGGGAGTGGTATTTGAAGTGTCCAGCAGTTGCTTGAAATGCTTTGCCGAATC
TGACTCCAGTAAGAATGTGGGAAAACCCCCTGTGTGTTCTGCAAGCAGGGCTCTTGCACCAGCGGTCTCCTCAGGGTGGACCTGCTTACA
GAGCAAGCCACGCCTCTTTCCGAGGTGAAGGTGGGACCATTCCTTGGGAAAGGATTCACAGTAAGGTTTTTTGGTTTTTGTTTTTTGTTT
TCTTGTTTTTAAAAAAAGGATTTCACAGTGAGAAAGTTTTGGTTAGTGCATACCGTGGAAGGGCGCCAGGGTCTTTGTGGATTGCATGTT
GACATTGACCGTGAGATTCGGCTTCAAACCAATACTGCCTTTGGAATATGACAGAATCAATAGCCCAGAGAGCTTAGTCAAAGACGATAT
CACGGTCTACCTTAACCAAGGCACTTTCTTAAGCAGAAAATATTGTTGAGGTTACCTTTGCTGCTAAAGATCCAATCTTCTAACGCCACA
ACAGCATAGCAAATCCTAGGATAATTCACCTCCTCATTTGACAAATCAGAGCTGTAATTCGCTTTAACAAATTACGCATTTCTATCACGT
TCACTAACAGCTTATGATAAGTCTGTGTAGTCTTCCTTTTCTCCAGTTCTGTTACCCAATTTAGATTAGTAAAGCGTACACAACTGGAAA
GACTGCTGTAATAACACAGCCTTGTTATTTTTAAGTCCTATTTTGATATTAATTTCTGATTAGTTAGTAAATAACACCTGGATTCTATGG
AGGACCTCGGTCTTCATCCAAGTGGCCTGAGTATTTCACTGGCAGGTTGTGAATTTTTCTTTTCCTCTTTGGGGATCCAAATGATGATGT
GCAATTTCATGTTTTAACTTGGGAAACTGAAAGTGTTCCCATATAGCTTCAAAAACAAAAACAAATGTGTTATCCGACGGATACTTTTAT
GGTTACTAACTAGTACTTTCCTAATTGGGAAAGTAGTGCTTAAGTTTGCAAATTAAGTTGGGGAGGGCAATAATAAAATGAGGGCCCGTA
ACAGAACCAGTGTGTGTATAACGAAAACCATGTATAAAATGGGCCTATCACCCTTGTCAGAGATATAAATTACCACATTTGCCTTCCCTT
CATCAGCTAACACTTATCACTTATACTACCAATAACTTGTTAAATCAGGATTTGGCTTCATACACTGAATTTTCAGTATTTTATCTCAAG
TAGATATAGACACTAACCTTGATAGTGATACGTTAGAGGGTTCCTATTCTTCCATTGTACGATAATGTCTTTAATATGAAATGCTACATT
ATTTATAATTGGTAGAGTTATTGTATCTTTTTATAGTTGTAAGTACACAGAGGTGGTATATTTAAACTTCTGTAATATACTGTATTTAGA
AATGGAAATATATATAGTGTTAGGTTTCACTTCTTTTAAGGTTTACCCCTGTGGTGTGGTTTAAAAATCTATAGGCCTGGGAATTCCGAT

>31352_31352_3_FRMD5-ALDH1A3_FRMD5_chr15_44487151_ENST00000417257_ALDH1A3_chr15_101425472_ENST00000329841_length(amino acids)=543AA_BP=64
MGSVRSCRAEGRLVQGPQRRRVAPGRAGGKMLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQIFINNEWHESKSGKKFATCNPSTREQ
ICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWAD
KIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPT
VGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSE
FVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPI
LKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGD

--------------------------------------------------------------
>31352_31352_4_FRMD5-ALDH1A3_FRMD5_chr15_44487151_ENST00000417257_ALDH1A3_chr15_101425472_ENST00000346623_length(transcript)=3251nt_BP=279nt
GGCTGAGGGAAGGAGGAGGATAAGGAGGAGGAACGAGGCCAGCAGGAGGCAACGGCAGCGACGGGGCCGGGGTGATGGTGCAGGTGCCTG
GGGTCGGTGCGGAGCTGCCGGGCTGAGGGACGCCTGGTCCAGGGTCCGCAGCGCCGCCGCGTCGCTCCCGGGCGGGCGGGCGGGAAGATG
CTGAGCAGGTTGATGAGCGGCAGCAGCAGGAGCCTGGAGCGCGAGTACAGCTGCACCGTGCGGCTGCTGGACGACAGCGAGTACACCTGC
ACCATCCAGATATTTATCAACAATGAATGGCACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTTGCCTTCCAGAGGGGCTCGCCATGGCGCCGG
CTGGATGCCCTGAGTCGTGGGCGGCTGCTGCACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCGGGTTCCCTCCA
GGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTGGGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGC
TCCACAGAGGTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAGCTGGGGGGGAAGAACCCCTGC
ATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAGTGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCC
TCCAGGGTGTTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAACGGCCCGTGGGAGACCCCTTC
GATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAGCAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCC
AAGCTGGAATGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAAGTCACAGACAACATGCGGATT
GCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTGAAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTAT
GGACTCACAGCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCTGGAACGGTCTGGATCAACTGC
TACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTTAAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATAC
ACAGAAGTGAAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGAAGGAAAGGCGGGGCTCCTTCCTCAAACATCGGACGGCGGAAT
GTGGCAGATGAAATGTGCTGGAGGAAAAAAATGACATTTCTGACCTTCCCGGGACACATTCTTCTGGAGGCTTTACATCTACTGGAGTTG
AATGATTGCTGTTTTCCTCTCACTCTCCTGTTTATTCACCAGACTGGGGATGCCTATAGGTTGTCTGTGAAATCGCAGTCCTGCCTGGGG
AGGGAGCTGTTGGCCATTTCTGTGTTTCCCTTTAAACCAGATCCTGGAGACAGTGAGATACTCAGGGCGTTGTTAACAGGGAGTGGTATT
TGAAGTGTCCAGCAGTTGCTTGAAATGCTTTGCCGAATCTGACTCCAGTAAGAATGTGGGAAAACCCCCTGTGTGTTCTGCAAGCAGGGC
TCTTGCACCAGCGGTCTCCTCAGGGTGGACCTGCTTACAGAGCAAGCCACGCCTCTTTCCGAGGTGAAGGTGGGACCATTCCTTGGGAAA
GGATTCACAGTAAGGTTTTTTGGTTTTTGTTTTTTGTTTTCTTGTTTTTAAAAAAAGGATTTCACAGTGAGAAAGTTTTGGTTAGTGCAT
ACCGTGGAAGGGCGCCAGGGTCTTTGTGGATTGCATGTTGACATTGACCGTGAGATTCGGCTTCAAACCAATACTGCCTTTGGAATATGA
CAGAATCAATAGCCCAGAGAGCTTAGTCAAAGACGATATCACGGTCTACCTTAACCAAGGCACTTTCTTAAGCAGAAAATATTGTTGAGG
TTACCTTTGCTGCTAAAGATCCAATCTTCTAACGCCACAACAGCATAGCAAATCCTAGGATAATTCACCTCCTCATTTGACAAATCAGAG
CTGTAATTCGCTTTAACAAATTACGCATTTCTATCACGTTCACTAACAGCTTATGATAAGTCTGTGTAGTCTTCCTTTTCTCCAGTTCTG
TTACCCAATTTAGATTAGTAAAGCGTACACAACTGGAAAGACTGCTGTAATAACACAGCCTTGTTATTTTTAAGTCCTATTTTGATATTA
ATTTCTGATTAGTTAGTAAATAACACCTGGATTCTATGGAGGACCTCGGTCTTCATCCAAGTGGCCTGAGTATTTCACTGGCAGGTTGTG
AATTTTTCTTTTCCTCTTTGGGGATCCAAATGATGATGTGCAATTTCATGTTTTAACTTGGGAAACTGAAAGTGTTCCCATATAGCTTCA
AAAACAAAAACAAATGTGTTATCCGACGGATACTTTTATGGTTACTAACTAGTACTTTCCTAATTGGGAAAGTAGTGCTTAAGTTTGCAA
ATTAAGTTGGGGAGGGCAATAATAAAATGAGGGCCCGTAACAGAACCAGTGTGTGTATAACGAAAACCATGTATAAAATGGGCCTATCAC
CCTTGTCAGAGATATAAATTACCACATTTGCCTTCCCTTCATCAGCTAACACTTATCACTTATACTACCAATAACTTGTTAAATCAGGAT
TTGGCTTCATACACTGAATTTTCAGTATTTTATCTCAAGTAGATATAGACACTAACCTTGATAGTGATACGTTAGAGGGTTCCTATTCTT
CCATTGTACGATAATGTCTTTAATATGAAATGCTACATTATTTATAATTGGTAGAGTTATTGTATCTTTTTATAGTTGTAAGTACACAGA
GGTGGTATATTTAAACTTCTGTAATATACTGTATTTAGAAATGGAAATATATATAGTGTTAGGTTTCACTTCTTTTAAGGTTTACCCCTG
TGGTGTGGTTTAAAAATCTATAGGCCTGGGAATTCCGATCCTAGCTGCAGATCGCATCCCACAATGCGAGAATGATAAAATAAAATTGGA

>31352_31352_4_FRMD5-ALDH1A3_FRMD5_chr15_44487151_ENST00000417257_ALDH1A3_chr15_101425472_ENST00000346623_length(amino acids)=436AA_BP=64
MGSVRSCRAEGRLVQGPQRRRVAPGRAGGKMLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQIFINNEWHESKSGKKFATCNPSTREQ
ICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFT
GSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDP
FDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FRMD5-ALDH1A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneFRMD5chr15:44487151chr15:101425472ENST00000417257-114308_35334.0571.0ROCK1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for FRMD5-ALDH1A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for FRMD5-ALDH1A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3554524MICROPHTHALMIA, ISOLATED 810CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0025202melanoma1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC1855052MICROPHTHALMIA, ISOLATED 11ORPHANET
TgeneC4551977Microphthalmos, Autosomal Recessive1ORPHANET