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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:API5-FOLH1 (FusionGDB2 ID:HG8539TG2346)

Fusion Gene Summary for API5-FOLH1

check button Fusion gene summary
Fusion gene informationFusion gene name: API5-FOLH1
Fusion gene ID: hg8539tg2346
HgeneTgene
Gene symbol

API5

FOLH1

Gene ID

8539

2346

Gene nameapoptosis inhibitor 5folate hydrolase 1
SynonymsAAC-11|AAC11FGCP|FOLH|GCP2|GCPII|NAALAD1|NAALAdase|PSM|PSMA|mGCP
Cytomap('API5')('FOLH1')

11p12

11p11.12

Type of geneprotein-codingprotein-coding
Descriptionapoptosis inhibitor 5FIFantiapoptosis clone 11 proteincell migration-inducing gene 8 proteinfibroblast growth factor 2-interacting factor 2migration-inducing protein MIG8glutamate carboxypeptidase 2N-acetylated alpha-linked acidic dipeptidase 1N-acetylated-alpha-linked acidic dipeptidase INAALADase Icell growth-inhibiting gene 27 proteinfolylpoly-gamma-glutamate carboxypeptidaseglutamate carboxylase IIglutamate car
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000529334, ENST00000378852, 
ENST00000420461, ENST00000455725, 
ENST00000531273, ENST00000534600, 
ENST00000534695, 
Fusion gene scores* DoF score7 X 5 X 5=1757 X 6 X 5=210
# samples 77
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: API5 [Title/Abstract] AND FOLH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPI5(43357544)-FOLH1(49168497), # samples:2
Anticipated loss of major functional domain due to fusion event.API5-FOLH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
API5-FOLH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
API5-FOLH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
API5-FOLH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
API5-FOLH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
API5-FOLH1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFOLH1

GO:0006508

proteolysis

12949938

TgeneFOLH1

GO:0035609

C-terminal protein deglutamylation

12949938|17241121|24863754


check buttonFusion gene breakpoints across API5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FOLH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-39-5016-01AAPI5chr11

43357544

+FOLH1chr11

49168497

-
ChimerDB4LUSCTCGA-39-5016API5chr11

43357544

+FOLH1chr11

49168497

-


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Fusion Gene ORF analysis for API5-FOLH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000529334ENST00000256999API5chr11

43357544

+FOLH1chr11

49168497

-
3UTR-3CDSENST00000529334ENST00000340334API5chr11

43357544

+FOLH1chr11

49168497

-
3UTR-3CDSENST00000529334ENST00000343844API5chr11

43357544

+FOLH1chr11

49168497

-
3UTR-3CDSENST00000529334ENST00000356696API5chr11

43357544

+FOLH1chr11

49168497

-
3UTR-3CDSENST00000529334ENST00000533034API5chr11

43357544

+FOLH1chr11

49168497

-
3UTR-intronENST00000529334ENST00000525629API5chr11

43357544

+FOLH1chr11

49168497

-
5CDS-intronENST00000378852ENST00000525629API5chr11

43357544

+FOLH1chr11

49168497

-
5CDS-intronENST00000420461ENST00000525629API5chr11

43357544

+FOLH1chr11

49168497

-
5CDS-intronENST00000455725ENST00000525629API5chr11

43357544

+FOLH1chr11

49168497

-
5CDS-intronENST00000531273ENST00000525629API5chr11

43357544

+FOLH1chr11

49168497

-
5CDS-intronENST00000534600ENST00000525629API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000378852ENST00000256999API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000378852ENST00000340334API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000378852ENST00000356696API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000378852ENST00000533034API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000420461ENST00000256999API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000420461ENST00000340334API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000420461ENST00000356696API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000420461ENST00000533034API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000455725ENST00000256999API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000455725ENST00000340334API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000455725ENST00000356696API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000455725ENST00000533034API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000531273ENST00000256999API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000531273ENST00000340334API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000531273ENST00000356696API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000531273ENST00000533034API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000534600ENST00000256999API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000534600ENST00000343844API5chr11

43357544

+FOLH1chr11

49168497

-
Frame-shiftENST00000534600ENST00000356696API5chr11

43357544

+FOLH1chr11

49168497

-
In-frameENST00000378852ENST00000343844API5chr11

43357544

+FOLH1chr11

49168497

-
In-frameENST00000420461ENST00000343844API5chr11

43357544

+FOLH1chr11

49168497

-
In-frameENST00000455725ENST00000343844API5chr11

43357544

+FOLH1chr11

49168497

-
In-frameENST00000531273ENST00000343844API5chr11

43357544

+FOLH1chr11

49168497

-
In-frameENST00000534600ENST00000340334API5chr11

43357544

+FOLH1chr11

49168497

-
In-frameENST00000534600ENST00000533034API5chr11

43357544

+FOLH1chr11

49168497

-
intron-3CDSENST00000534695ENST00000256999API5chr11

43357544

+FOLH1chr11

49168497

-
intron-3CDSENST00000534695ENST00000340334API5chr11

43357544

+FOLH1chr11

49168497

-
intron-3CDSENST00000534695ENST00000343844API5chr11

43357544

+FOLH1chr11

49168497

-
intron-3CDSENST00000534695ENST00000356696API5chr11

43357544

+FOLH1chr11

49168497

-
intron-3CDSENST00000534695ENST00000533034API5chr11

43357544

+FOLH1chr11

49168497

-
intron-intronENST00000534695ENST00000525629API5chr11

43357544

+FOLH1chr11

49168497

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000455725API5chr1143357544+ENST00000343844FOLH1chr1149168497-201417042451825526
ENST00000531273API5chr1143357544+ENST00000343844FOLH1chr1149168497-194116311211752543
ENST00000420461API5chr1143357544+ENST00000343844FOLH1chr1149168497-177014601121581489
ENST00000378852API5chr1143357544+ENST00000343844FOLH1chr1149168497-192716171071738543
ENST00000534600API5chr1143357544+ENST00000340334FOLH1chr1149168497-19331623141390458
ENST00000534600API5chr1143357544+ENST00000533034FOLH1chr1149168497-18181623141390458

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000455725ENST00000343844API5chr1143357544+FOLH1chr1149168497-0.0027486070.99725133
ENST00000531273ENST00000343844API5chr1143357544+FOLH1chr1149168497-0.0011286360.9988714
ENST00000420461ENST00000343844API5chr1143357544+FOLH1chr1149168497-0.0012452860.99875474
ENST00000378852ENST00000343844API5chr1143357544+FOLH1chr1149168497-0.0011467970.9988532
ENST00000534600ENST00000340334API5chr1143357544+FOLH1chr1149168497-0.0004484750.9995515
ENST00000534600ENST00000533034API5chr1143357544+FOLH1chr1149168497-0.000592170.9994079

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Fusion Genomic Features for API5-FOLH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for API5-FOLH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:43357544/chr11:49168497)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPI5chr11:43357544chr11:49168497ENST00000378852+1314454_475497505.0MotifNuclear localization signal
HgeneAPI5chr11:43357544chr11:49168497ENST00000531273+1314454_475497525.0MotifNuclear localization signal
HgeneAPI5chr11:43357544chr11:49168497ENST00000378852+13142_360497505.0RegionNote=ARM-like and Heat-like helical repeats
HgeneAPI5chr11:43357544chr11:49168497ENST00000378852+1314370_391497505.0RegionNote=Leucine-zipper
HgeneAPI5chr11:43357544chr11:49168497ENST00000420461+12132_360443451.0RegionNote=ARM-like and Heat-like helical repeats
HgeneAPI5chr11:43357544chr11:49168497ENST00000420461+1213370_391443451.0RegionNote=Leucine-zipper
HgeneAPI5chr11:43357544chr11:49168497ENST00000531273+13142_360497525.0RegionNote=ARM-like and Heat-like helical repeats
HgeneAPI5chr11:43357544chr11:49168497ENST00000531273+1314370_391497525.0RegionNote=Leucine-zipper
TgeneFOLH1chr11:43357544chr11:49168497ENST000002569991719699_700687751.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000003403341820699_700672736.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000003438441517517_518379443.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000003438441517534_536379443.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000003438441517552_553379443.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000003438441517699_700379443.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000003566961618699_700656720.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000005330341719699_700641705.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPI5chr11:43357544chr11:49168497ENST00000420461+1213454_475443451.0MotifNuclear localization signal
TgeneFOLH1chr11:43357544chr11:49168497ENST000002569991719146_149687751.0Compositional biasPoly-Pro
TgeneFOLH1chr11:43357544chr11:49168497ENST000003403341820146_149672736.0Compositional biasPoly-Pro
TgeneFOLH1chr11:43357544chr11:49168497ENST000003438441517146_149379443.0Compositional biasPoly-Pro
TgeneFOLH1chr11:43357544chr11:49168497ENST000003566961618146_149656720.0Compositional biasPoly-Pro
TgeneFOLH1chr11:43357544chr11:49168497ENST000005330341719146_149641705.0Compositional biasPoly-Pro
TgeneFOLH1chr11:43357544chr11:49168497ENST000002569991719274_587687751.0RegionNote=NAALADase
TgeneFOLH1chr11:43357544chr11:49168497ENST000002569991719517_518687751.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000002569991719534_536687751.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000002569991719552_553687751.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000003403341820274_587672736.0RegionNote=NAALADase
TgeneFOLH1chr11:43357544chr11:49168497ENST000003403341820517_518672736.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000003403341820534_536672736.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000003403341820552_553672736.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000003438441517274_587379443.0RegionNote=NAALADase
TgeneFOLH1chr11:43357544chr11:49168497ENST000003566961618274_587656720.0RegionNote=NAALADase
TgeneFOLH1chr11:43357544chr11:49168497ENST000003566961618517_518656720.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000003566961618534_536656720.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000003566961618552_553656720.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000005330341719274_587641705.0RegionNote=NAALADase
TgeneFOLH1chr11:43357544chr11:49168497ENST000005330341719517_518641705.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000005330341719534_536641705.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST000005330341719552_553641705.0RegionSubstrate binding
TgeneFOLH1chr11:43357544chr11:49168497ENST0000025699917191_19687751.0Topological domainCytoplasmic
TgeneFOLH1chr11:43357544chr11:49168497ENST00000256999171944_750687751.0Topological domainExtracellular
TgeneFOLH1chr11:43357544chr11:49168497ENST0000034033418201_19672736.0Topological domainCytoplasmic
TgeneFOLH1chr11:43357544chr11:49168497ENST00000340334182044_750672736.0Topological domainExtracellular
TgeneFOLH1chr11:43357544chr11:49168497ENST0000034384415171_19379443.0Topological domainCytoplasmic
TgeneFOLH1chr11:43357544chr11:49168497ENST00000343844151744_750379443.0Topological domainExtracellular
TgeneFOLH1chr11:43357544chr11:49168497ENST0000035669616181_19656720.0Topological domainCytoplasmic
TgeneFOLH1chr11:43357544chr11:49168497ENST00000356696161844_750656720.0Topological domainExtracellular
TgeneFOLH1chr11:43357544chr11:49168497ENST0000053303417191_19641705.0Topological domainCytoplasmic
TgeneFOLH1chr11:43357544chr11:49168497ENST00000533034171944_750641705.0Topological domainExtracellular
TgeneFOLH1chr11:43357544chr11:49168497ENST00000256999171920_43687751.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneFOLH1chr11:43357544chr11:49168497ENST00000340334182020_43672736.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneFOLH1chr11:43357544chr11:49168497ENST00000343844151720_43379443.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneFOLH1chr11:43357544chr11:49168497ENST00000356696161820_43656720.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneFOLH1chr11:43357544chr11:49168497ENST00000533034171920_43641705.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for API5-FOLH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5420_5420_1_API5-FOLH1_API5_chr11_43357544_ENST00000378852_FOLH1_chr11_49168497_ENST00000343844_length(transcript)=1927nt_BP=1617nt
GCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCGCCGGTCAGGACAAG
GATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGCCACGG
AGCAAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTA
TTCCGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTC
GACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAG
ATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCC
AAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAA
AGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATTTGTTCTATTTATGAAGATACTGT
CTGGGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGCCGACCTAGAACAGACCTTCAATC
CCTCGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAAAAATGTCCATTCCACAAGGTTTG
TGACATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGATATACAGTTGGAGGTATTGAAAT
TGTTGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATTTGATAAGTTATTGGAATACATGC
CCCTCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAGTTATGTGGAATGTTTGTTGTACA
GTTTTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAAAGATTTCAAAATCAGGCTGCAGT
ACTTTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGAGGCCTTAAAAACAGAAGAGAACA
AGATTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACATTCCTCCTTCTTATAAGAGCACAG
TAACACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACAACTTCAGGTTCACCACCCAAGAAAT
CTTCAGCAGGACCAAAAAGAGATGCCAGGCAGATTTATAACCCTCCCAGTGGGAAATATAGCAGCAATTTGGGCAACTTTAATTATGGCA
TGTCATCTATGCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCTCTGTTTGATATTGAAAGCAAAGT
GGACCCTTCCAAGGCCTGGGGAGAAGTGAAGAGACAGATTTATGTTGCAGCCTTCACAGTGCAGGCAGCTGCAGAGACTTTGAGTGAAGT
AGCCTAAGAGGATTCTTTAGAGAATCCGTATTGAATTTGTGTGGTATGTCACTCAGAAAGAATCGTAATGGGTATATTGATAAATTTTAA
AATTGGTATATTTGAAATAAAGTTGAATATTATATAT

>5420_5420_1_API5-FOLH1_API5_chr11_43357544_ENST00000378852_FOLH1_chr11_49168497_ENST00000343844_length(amino acids)=543AA_BP=503
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCE
QVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLG
RKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWK
PVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYGMSSMLQAATTSMQGSHSQEFMMLCLILKAKWTLPRP
GEK

--------------------------------------------------------------
>5420_5420_2_API5-FOLH1_API5_chr11_43357544_ENST00000420461_FOLH1_chr11_49168497_ENST00000343844_length(transcript)=1770nt_BP=1460nt
GACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCGCCGGTCAGG
ACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGC
CACGGAGCAAGTGGGCCAGATTCGACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATAT
ACTAACGCAACTTTTGCAGACAGATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGG
GACTTTAGGTGGGTTGTTCAGCCAAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGAC
TTTACCAGATGAAGTCTTAACAAAGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATT
TGTTCTATTTATGAAGATACTGTCTGGGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGC
CGACCTAGAACAGACCTTCAATCCCTCGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAA
AAATGTCCATTCCACAAGGTTTGTGACATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGA
TATACAGTTGGAGGTATTGAAATTGTTGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATT
TGATAAGTTATTGGAATACATGCCCCTCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAG
TTATGTGGAATGTTTGTTGTACAGTTTTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAA
AGATTTCAAAATCAGGCTGCAGTACTTTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGA
GGCCTTAAAAACAGAAGAGAACAAGATTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACAT
TCCTCCTTCTTATAAGAGCACAGTAACACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACAAC
TTCAGGTTCACCACCCAAGAAATCTTCAGCAGGACCAAAAAGAGATGCCAGGCAGATTTATAACCCTCCCAGTGGGAAATATAGCAGCAA
TTTGGGCAACTTTAATTATGGCATGTCATCTATGCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCT
CTGTTTGATATTGAAAGCAAAGTGGACCCTTCCAAGGCCTGGGGAGAAGTGAAGAGACAGATTTATGTTGCAGCCTTCACAGTGCAGGCA
GCTGCAGAGACTTTGAGTGAAGTAGCCTAAGAGGATTCTTTAGAGAATCCGTATTGAATTTGTGTGGTATGTCACTCAGAAAGAATCGTA
ATGGGTATATTGATAAATTTTAAAATTGGTATATTTGAAATAAAGTTGAATATTATATAT

>5420_5420_2_API5-FOLH1_API5_chr11_43357544_ENST00000420461_FOLH1_chr11_49168497_ENST00000343844_length(amino acids)=489AA_BP=449
MGLSLTMPTVEELYRNYGILADATEQVGQIRRQAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFS
QILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFN
PSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYM
PLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEEN
KIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYG
MSSMLQAATTSMQGSHSQEFMMLCLILKAKWTLPRPGEK

--------------------------------------------------------------
>5420_5420_3_API5-FOLH1_API5_chr11_43357544_ENST00000455725_FOLH1_chr11_49168497_ENST00000343844_length(transcript)=2014nt_BP=1704nt
GCAGCCGCGCTGTGCGCGGTGACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGG
CGGCGGTGGCGCCGGTCAGGACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAAT
TATGGCATCCTGGCCGATGCCACGGAGCAAGTGGGCCAGACTCATCCATCTCCCCCAACTCAAAAATGAAACAAAGATGGAGGGAGAACG
GAATTGGGAAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTATTC
CGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTCGAC
GTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAGATG
ACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCCAAA
TACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAAAGG
AAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATTTGTTCTATTTATGAAGATACTGTCTG
GGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGCCGACCTAGAACAGACCTTCAATCCCT
CGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAAAAATGTCCATTCCACAAGGTTTGTGA
CATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGATATACAGTTGGAGGTATTGAAATTGT
TGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATTTGATAAGTTATTGGAATACATGCCCC
TCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAGTTATGTGGAATGTTTGTTGTACAGTT
TTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAAAGATTTCAAAATCAGGCTGCAGTACT
TTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGAGGCCTTAAAAACAGAAGAGAACAAGA
TTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACATTCCTCCTTCTTATAAGAGCACAGTAA
CACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACAACTTCAGGTTCACCACCCAAGAAATCTT
CAGCAGGACCAAAAAGAGATGCCAGGCAGATTTATAACCCTCCCAGTGGGAAATATAGCAGCAATTTGGGCAACTTTAATTATGGCATGT
CATCTATGCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCTCTGTTTGATATTGAAAGCAAAGTGGA
CCCTTCCAAGGCCTGGGGAGAAGTGAAGAGACAGATTTATGTTGCAGCCTTCACAGTGCAGGCAGCTGCAGAGACTTTGAGTGAAGTAGC
CTAAGAGGATTCTTTAGAGAATCCGTATTGAATTTGTGTGGTATGTCACTCAGAAAGAATCGTAATGGGTATATTGATAAATTTTAAAAT
TGGTATATTTGAAATAAAGTTGAATATTATATAT

>5420_5420_3_API5-FOLH1_API5_chr11_43357544_ENST00000455725_FOLH1_chr11_49168497_ENST00000343844_length(amino acids)=526AA_BP=486
MKQRWRENGIGKHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADI
LTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEF
VLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLGTLTTPVEGLD
IQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLK
DFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRASEDTT
SGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYGMSSMLQAATTSMQGSHSQEFMMLCLILKAKWTLPRPGEK

--------------------------------------------------------------
>5420_5420_4_API5-FOLH1_API5_chr11_43357544_ENST00000531273_FOLH1_chr11_49168497_ENST00000343844_length(transcript)=1941nt_BP=1631nt
GTGCGCGGTGACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCG
CCGGTCAGGACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCT
GGCCGATGCCACGGAGCAAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATT
AGCAGCTCAATTTATTCCGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGA
AGATGTATCTATTCGACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCA
ACTTTTGCAGACAGATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGG
TGGGTTGTTCAGCCAAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGA
TGAAGTCTTAACAAAGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATTTGTTCTATT
TATGAAGATACTGTCTGGGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGCCGACCTAGA
ACAGACCTTCAATCCCTCGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAAAAATGTCCA
TTCCACAAGGTTTGTGACATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGATATACAGTT
GGAGGTATTGAAATTGTTGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATTTGATAAGTT
ATTGGAATACATGCCCCTCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAGTTATGTGGA
ATGTTTGTTGTACAGTTTTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAAAGATTTCAA
AATCAGGCTGCAGTACTTTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGAGGCCTTAAA
AACAGAAGAGAACAAGATTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACATTCCTCCTTC
TTATAAGAGCACAGTAACACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACAACTTCAGGTTC
ACCACCCAAGAAATCTTCAGCAGGACCAAAAAGAGATGCCAGGCAGATTTATAACCCTCCCAGTGGGAAATATAGCAGCAATTTGGGCAA
CTTTAATTATGGCATGTCATCTATGCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCTCTGTTTGAT
ATTGAAAGCAAAGTGGACCCTTCCAAGGCCTGGGGAGAAGTGAAGAGACAGATTTATGTTGCAGCCTTCACAGTGCAGGCAGCTGCAGAG
ACTTTGAGTGAAGTAGCCTAAGAGGATTCTTTAGAGAATCCGTATTGAATTTGTGTGGTATGTCACTCAGAAAGAATCGTAATGGGTATA
TTGATAAATTTTAAAATTGGTATATTTGAAATAAAGTTGAATATTATATAT

>5420_5420_4_API5-FOLH1_API5_chr11_43357544_ENST00000531273_FOLH1_chr11_49168497_ENST00000343844_length(amino acids)=543AA_BP=503
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCE
QVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLG
RKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWK
PVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYGMSSMLQAATTSMQGSHSQEFMMLCLILKAKWTLPRP
GEK

--------------------------------------------------------------
>5420_5420_5_API5-FOLH1_API5_chr11_43357544_ENST00000534600_FOLH1_chr11_49168497_ENST00000340334_length(transcript)=1933nt_BP=1623nt
AGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGCCACGGAGC
AAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTATTC
CGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTCGAC
GTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAGATG
ACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCCAAA
TACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAAAGG
AAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATTTGTTCTATTTATGAAGATACTGTCTG
GGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGCCGACCTAGAACAGACCTTCAATCCCT
CGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAAAAATGTCCATTCCACAAGGTTTGTGA
CATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGATATACAGTTGGAGGTATTGAAATTGT
TGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATTTGATAAGTTATTGGAATACATGCCCC
TCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAGTTATGTGGAATGTTTGTTGTACAGTT
TTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAAAGATTTCAAAATCAGGCTGCAGTACT
TTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGAGGCCTTAAAAACAGAAGAGAACAAGA
TTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACATTCCTCCTTCTTATAAGAGCACAGTAA
CACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGTGAGCGTTTCCGTTTGGGTACAAGGAATATGAGAGATTAGGCAGAAATTGTG
TTATACTTTATTTTAATTAGTAATTATATACAGTGTCATGGTTCTATCCAATGACTTTTCTGAATTAGCTTGGAGAACTAGGGCTGTTGA
GGAAATGATTTATCCCATTCCTCTCTCATTCACCCTTCTGGGCTGACTGTATTGAACATGCAACATTAAACAGTAAGCACTTAAAGAAAA
ATAGCATGTCATCTATGCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCTCTGTTTGATATTGAAAG
CAAAGTGGACCCTTCCAAGGCCTGGGGAGAAGTGAAGAGACAGATTTATGTTGCAGCCTTCACAGTGCAGGCAGCTGCAGAGACTTTGAG
TGAAGTAGCCTAAGAGGATTCTTTAGAGAATCCGTATTGAATTTGTGTGGTATGTCACTCAGAAAGAATCGTAATGGGTATATTGATAAA
TTTTAAAATTGGTATATTTGAAATAAAGTTGAATATTATATAT

>5420_5420_5_API5-FOLH1_API5_chr11_43357544_ENST00000534600_FOLH1_chr11_49168497_ENST00000340334_length(amino acids)=458AA_BP=
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCE
QVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLG
RKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWK
PVQKVEIG

--------------------------------------------------------------
>5420_5420_6_API5-FOLH1_API5_chr11_43357544_ENST00000534600_FOLH1_chr11_49168497_ENST00000533034_length(transcript)=1818nt_BP=1623nt
AGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGCCACGGAGC
AAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTATTC
CGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTCGAC
GTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAGATG
ACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCCAAA
TACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAAAGG
AAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATTTGTTCTATTTATGAAGATACTGTCTG
GGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGCCGACCTAGAACAGACCTTCAATCCCT
CGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAAAAATGTCCATTCCACAAGGTTTGTGA
CATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGATATACAGTTGGAGGTATTGAAATTGT
TGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATTTGATAAGTTATTGGAATACATGCCCC
TCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAGTTATGTGGAATGTTTGTTGTACAGTT
TTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAAAGATTTCAAAATCAGGCTGCAGTACT
TTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGAGGCCTTAAAAACAGAAGAGAACAAGA
TTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACATTCCTCCTTCTTATAAGAGCACAGTAA
CACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGTGAGCGTTTCCGTTTGGGTACAAGGAATATGAGAGATTAGGCAGAAATTGTG
TTATACTTTATTTTAATTAGTAATTATATACAGTGTCATGGTTCTATCCAATGACTTTTCTGAATTAGCTTGGAGAACTAGGGCTGTTGA
GGAAATGATTTATCCCATTCCTCTCTCATTCACCCTTCTGGGCTGACTGTATTGAACATGCAACATTAAACAGTAAGCACTTAAAGAAAA
ATAGCATGTCATCTATGCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCTCTGTTTGATATTGAAAG
CAAAGTGGACCCTTCCAAGGCCTGGGGAGAAGTGAAGAGACAGATTTATGTTGCAGCCTTCACAGTGCAGGCAGCTGCAGAGACTTTGAG
TGAAGTAGCCTAAGAGGA

>5420_5420_6_API5-FOLH1_API5_chr11_43357544_ENST00000534600_FOLH1_chr11_49168497_ENST00000533034_length(amino acids)=458AA_BP=
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCE
QVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLG
RKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWK
PVQKVEIG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for API5-FOLH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for API5-FOLH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for API5-FOLH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0033578Prostatic Neoplasms2CTD_human
TgeneC0036341Schizophrenia2PSYGENET
TgeneC0376358Malignant neoplasm of prostate2CTD_human
TgeneC0011570Mental Depression1PSYGENET
TgeneC0011581Depressive disorder1PSYGENET