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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:API5-GANC (FusionGDB2 ID:HG8539TG2595)

Fusion Gene Summary for API5-GANC

check button Fusion gene summary
Fusion gene informationFusion gene name: API5-GANC
Fusion gene ID: hg8539tg2595
HgeneTgene
Gene symbol

API5

GANC

Gene ID

8539

2595

Gene nameapoptosis inhibitor 5glucosidase alpha, neutral C
SynonymsAAC-11|AAC11-
Cytomap('API5')('GANC')

11p12

15q15.1

Type of geneprotein-codingprotein-coding
Descriptionapoptosis inhibitor 5FIFantiapoptosis clone 11 proteincell migration-inducing gene 8 proteinfibroblast growth factor 2-interacting factor 2migration-inducing protein MIG8neutral alpha-glucosidase C
Modification date2020031320200313
UniProtAcc.

Q8TET4

Ensembl transtripts involved in fusion geneENST00000378852, ENST00000420461, 
ENST00000455725, ENST00000531273, 
ENST00000534600, ENST00000529334, 
ENST00000534695, 
Fusion gene scores* DoF score7 X 5 X 5=1757 X 6 X 3=126
# samples 76
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/126*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: API5 [Title/Abstract] AND GANC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPI5(43343686)-GANC(42598744), # samples:3
Anticipated loss of major functional domain due to fusion event.API5-GANC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
API5-GANC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across API5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GANC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FS-A4FB-06AAPI5chr11

43343686

-GANCchr15

42598744

+
ChimerDB4SKCMTCGA-FS-A4FB-06AAPI5chr11

43343686

+GANCchr15

42598744

+


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Fusion Gene ORF analysis for API5-GANC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000378852ENST00000440615API5chr11

43343686

+GANCchr15

42598744

+
5CDS-intronENST00000420461ENST00000440615API5chr11

43343686

+GANCchr15

42598744

+
5CDS-intronENST00000455725ENST00000440615API5chr11

43343686

+GANCchr15

42598744

+
5CDS-intronENST00000531273ENST00000440615API5chr11

43343686

+GANCchr15

42598744

+
5CDS-intronENST00000534600ENST00000440615API5chr11

43343686

+GANCchr15

42598744

+
In-frameENST00000378852ENST00000318010API5chr11

43343686

+GANCchr15

42598744

+
In-frameENST00000378852ENST00000566442API5chr11

43343686

+GANCchr15

42598744

+
In-frameENST00000420461ENST00000318010API5chr11

43343686

+GANCchr15

42598744

+
In-frameENST00000420461ENST00000566442API5chr11

43343686

+GANCchr15

42598744

+
In-frameENST00000455725ENST00000318010API5chr11

43343686

+GANCchr15

42598744

+
In-frameENST00000455725ENST00000566442API5chr11

43343686

+GANCchr15

42598744

+
In-frameENST00000531273ENST00000318010API5chr11

43343686

+GANCchr15

42598744

+
In-frameENST00000531273ENST00000566442API5chr11

43343686

+GANCchr15

42598744

+
In-frameENST00000534600ENST00000318010API5chr11

43343686

+GANCchr15

42598744

+
In-frameENST00000534600ENST00000566442API5chr11

43343686

+GANCchr15

42598744

+
intron-3CDSENST00000529334ENST00000318010API5chr11

43343686

+GANCchr15

42598744

+
intron-3CDSENST00000529334ENST00000566442API5chr11

43343686

+GANCchr15

42598744

+
intron-3CDSENST00000534695ENST00000318010API5chr11

43343686

+GANCchr15

42598744

+
intron-3CDSENST00000534695ENST00000566442API5chr11

43343686

+GANCchr15

42598744

+
intron-intronENST00000529334ENST00000440615API5chr11

43343686

+GANCchr15

42598744

+
intron-intronENST00000534695ENST00000440615API5chr11

43343686

+GANCchr15

42598744

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000455725API5chr1143343686+ENST00000566442GANCchr1542598744+20087552451270341
ENST00000455725API5chr1143343686+ENST00000318010GANCchr1542598744+44697552452941898
ENST00000531273API5chr1143343686+ENST00000566442GANCchr1542598744+19356821211197358
ENST00000531273API5chr1143343686+ENST00000318010GANCchr1542598744+43966821212868915
ENST00000420461API5chr1143343686+ENST00000566442GANCchr1542598744+17645111121026304
ENST00000420461API5chr1143343686+ENST00000318010GANCchr1542598744+42255111122697861
ENST00000378852API5chr1143343686+ENST00000566442GANCchr1542598744+19216681071183358
ENST00000378852API5chr1143343686+ENST00000318010GANCchr1542598744+43826681072854915
ENST00000534600API5chr1143343686+ENST00000566442GANCchr1542598744+1828575141090358
ENST00000534600API5chr1143343686+ENST00000318010GANCchr1542598744+4289575142761915

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000455725ENST00000566442API5chr1143343686+GANCchr1542598744+0.0021842150.9978157
ENST00000455725ENST00000318010API5chr1143343686+GANCchr1542598744+0.0012277970.9987722
ENST00000531273ENST00000566442API5chr1143343686+GANCchr1542598744+0.000669030.999331
ENST00000531273ENST00000318010API5chr1143343686+GANCchr1542598744+0.0008313660.99916863
ENST00000420461ENST00000566442API5chr1143343686+GANCchr1542598744+0.0007221240.9992779
ENST00000420461ENST00000318010API5chr1143343686+GANCchr1542598744+0.0010109290.99898905
ENST00000378852ENST00000566442API5chr1143343686+GANCchr1542598744+0.0006668650.9993331
ENST00000378852ENST00000318010API5chr1143343686+GANCchr1542598744+0.0008408110.9991592
ENST00000534600ENST00000566442API5chr1143343686+GANCchr1542598744+0.0006686810.99933136
ENST00000534600ENST00000318010API5chr1143343686+GANCchr1542598744+0.0008618250.9991381

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Fusion Genomic Features for API5-GANC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
API5chr1143343686+GANCchr1542598743+3.14E-060.9999969
API5chr1143343686+GANCchr1542598743+3.14E-060.9999969

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for API5-GANC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:43343686/chr15:42598744)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GANC

Q8TET4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Has alpha-glucosidase activity. {ECO:0000269|PubMed:12370436}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPI5chr11:43343686chr15:42598744ENST00000378852+514454_475181505.0MotifNuclear localization signal
HgeneAPI5chr11:43343686chr15:42598744ENST00000420461+413454_475127451.0MotifNuclear localization signal
HgeneAPI5chr11:43343686chr15:42598744ENST00000531273+514454_475181525.0MotifNuclear localization signal
HgeneAPI5chr11:43343686chr15:42598744ENST00000378852+5142_360181505.0RegionNote=ARM-like and Heat-like helical repeats
HgeneAPI5chr11:43343686chr15:42598744ENST00000378852+514370_391181505.0RegionNote=Leucine-zipper
HgeneAPI5chr11:43343686chr15:42598744ENST00000420461+4132_360127451.0RegionNote=ARM-like and Heat-like helical repeats
HgeneAPI5chr11:43343686chr15:42598744ENST00000420461+413370_391127451.0RegionNote=Leucine-zipper
HgeneAPI5chr11:43343686chr15:42598744ENST00000531273+5142_360181525.0RegionNote=ARM-like and Heat-like helical repeats
HgeneAPI5chr11:43343686chr15:42598744ENST00000531273+514370_391181525.0RegionNote=Leucine-zipper


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Fusion Gene Sequence for API5-GANC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5422_5422_1_API5-GANC_API5_chr11_43343686_ENST00000378852_GANC_chr15_42598744_ENST00000318010_length(transcript)=4382nt_BP=668nt
GCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCGCCGGTCAGGACAAG
GATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGCCACGG
AGCAAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTA
TTCCGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTC
GACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAG
ATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCC
AAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAA
AGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGAAAATCAAGAAGATCTGGGCCTGTGGGAAGAGAAATTTGGAAAATTTGTGG
ATATCAAAGCTAATGGCCCTTCTTCTATTGGTTTGGATTTCTCCTTGCATGGATTTGAGCATCTTTATGGGATCCCACAACATGCAGAAT
CACACCAACTTAAAAATACTGGTGATGGAGATGCTTACCGTCTTTATAACCTGGATGTCTATGGATACCAAATATATGATAAAATGGGCA
TTTATGGTTCAGTACCTTATCTCCTGGCCCACAAACTGGGCAGAACTATAGGTATTTTCTGGCTGAATGCCTCGGAAACACTGGTGGAGA
TCAATACAGAGCCTGCAGTAGAGTACACACTGACCCAGATGGGCCCAGTTGCTGCTAAACAAAAGGTCAGATCTCGCACTCATGTGCACT
GGATGTCAGAGAGTGGCATCATTGATGTTTTTCTGCTGACAGGACCTACACCTTCTGATGTCTTCAAACAGTACTCACACCTTACAGGCA
CACAAGCCATGCCCCCTCTTTTCTCTTTGGGATACCACCAGTGCCGCTGGAACTATGAAGATGAGCAGGATGTAAAAGCAGTGGATGCAG
GGTTTGATGAGCATGACATTCCTTATGATGCCATGTGGCTGGACATAGAGCACACTGAGGGCAAGAGGTACTTCACCTGGGACAAAAACA
GATTCCCAAACCCCAAGAGGATGCAAGAGCTGCTCAGGAGCAAAAAGCGTAAGCTTGTGGTCATCAGTGATCCCCACATCAAGATTGATC
CTGACTACTCAGTATATGTGAAGGCCAAAGATCAGGGCTTCTTTGTGAAGAATCAGGAAGGGGAAGACTTTGAAGGGGTGTGTTGGCCAG
GTCTCTCCTCTTACCTGGATTTCACCAATCCCAAGGTCAGAGAGTGGTATTCAAGTCTTTTTGCTTTCCCTGTTTATCAGGGATCTACGG
ACATCCTCTTCCTTTGGAATGACATGAATGAGCCTTCTGTCTTTAGAGGGCCAGAGCAAACCATGCAGAAGAATGCCATTCATCATGGCA
ATTGGGAGCACAGAGAGCTCCACAACATCTACGGTTTTTATCATCAAATGGCTACTGCAGAAGGACTGATAAAACGATCTAAAGGGAAGG
AGAGACCCTTTGTTCTTACACGTTCTTTCTTTGCTGGATCACAAAAGTATGGTGCCGTGTGGACAGGCGACAACACAGCAGAATGGAGCA
ACTTGAAAATTTCTATCCCAATGTTACTCACTCTCAGCATTACTGGGATCTCTTTTTGCGGAGCTGACATAGGCGGGTTCATTGGGAATC
CAGAGACAGAGCTGCTAGTGCGTTGGTACCAGGCTGGAGCCTACCAGCCCTTCTTCCGTGGCCATGCCACCATGAACACCAAGCGACGAG
AGCCCTGGCTCTTTGGGGAGGAACACACCCGACTCATCCGAGAAGCCATCAGAGAGCGCTATGGCCTCCTGCCATATTGGTATTCTCTGT
TCTACCATGCACACGTGGCTTCCCAACCTGTCATGAGGCCTCTGTGGGTAGAGTTCCCTGATGAACTAAAGACTTTTGATATGGAAGATG
AATACATGCTGGGGAGTGCATTATTGGTTCATCCAGTCACAGAACCAAAAGCCACCACAGTTGATGTGTTTCTTCCAGGATCAAATGAGG
TCTGGTATGACTATAAGACATTTGCTCATTGGGAAGGAGGGTGTACTGTAAAGATCCCAGTAGCCTTGGACACTATTCCAGTGTTTCAGC
GAGGTGGAAGTGTGATACCAATAAAGACAACTGTAGGAAAATCCACAGGCTGGATGACTGAATCCTCCTATGGACTCCGGGTTGCTCTAA
GCACTAAGGGTTCTTCAGTGGGTGAGTTATATCTTGATGATGGCCATTCATTCCAATACCTCCACCAGAAGCAATTTTTGCACAGGAAGT
TTTCATTCTGTTCCAGTGTTCTGATCAATAGTTTTGCTGACCAGAGGGGTCATTATCCCAGCAAGTGTGTGGTGGAGAAGATCTTGGTCT
TAGGCTTCAGGAAGGAGCCATCTTCTGTGACTACCCACTCATCTGATGGTAAAGATCAGCCTGTGGCTTTTACGTATTGTGCCAAAACAT
CCATCCTGAGCCTGGAGAAGCTCTCACTCAACATTGCCACTGACTGGGAGGTCCGCATCATATGACAAAGAACTGCCCCTGGTGATGTGA
GCAGGGACCTGCCTGCCCCTTTCAACCTTTCCCCTCACCTTTTTTGAGATTTTTGCTGCAATCTGTTTGCCTTCCCTGAATCAAAATAAT
CTTTCATTCGTCACCATTATACTAATGAACAATAGATTTCATGTTTCAAAATTTCAGATTTTACATGTTAAGATGTACTAACAATATTCC
TTGTATCAAACATCTCCTTTTCTCCCTGATACATAGCCCTGAGACATTTATAGCGTTCAGGAGTCTTCTATTGCTTCCATTCCTTCAGCA
GGGCTGCGTGGGTCTGTTTTAACGTGGGCCAAGCCTACCTGGGCAGCCCATTTGCCAGGGCTTGCCTCAGGCCATGCAGCATTGGCGCTC
TGGCTGCAGCAGCTGAGTTGCTCAAGGCCAGTGTCCAAGTGGACAGCAGCCTCTGGTACTCCCCCCAGTTATCTTCCACCCACATGGACT
GGGCAGAGCAGCCCTCTTCTGTGTGCACTGCATACGCTGCAGCCGTGGGAGTTATTCTCCCCTAGAGATCGACTTGGCAGCACGAAGGAT
TCTTTTCTCTTTCATGCTTCTCAGGCTCAATAGTTTCTAATTAATCTTAAAATCCATGTCTTTTACATTGTTTTTTTAATTAAGTGCTGT
TTACTAACCAAATAATATTTATAACATGAGTAAGCTATAATTAATAACAATGAAATAAATACCCATGTACCCACCACTGGACTTCAGAAG
TAGAACTCATGACTGGGACTAGGATGAGGCAAGGGAGACCCTGGCCTTGGGCACAAAATGTAAGGGATGCCAAAAAAATACAGTAATCAA
AGTAAGTAATATTTCAATCCAATATTTTTAAAAATCAGAATTAATGCAAAAAAAACCATGATGAACAAAATATTAAAATTTAAAATAAAG
ACAGGATTAGTATTACTGAGTTTTCCTTTTGTCCCAGGCTCTAATATGGCTTGGCATGGGGCAGAACATTACAACATACCAGTCGTGTCA
TGGTGCCCAAGGCTCCACAGACCTCAGTGGCTCCCTGCTGCCTGCCACAGCATCTGTTTTAGCAGCCTCGACTCCTCAGCACTCCTCAGC
ACACACCTCTTCTTATCAGGCTTCCTCCACTTAGCAACTTGCTAACGGCCACCTCTGTGCCTTCTGATCCCTGGGCGCCAATATCCTCCT
GCCCTTACCATCCTTCCAGGCCCAACTTAAATCCCACTTTCCCATGAAGCCTAACTGCGTGAACACCCCTACCCCCATACCCATTAGCAG
TGATTTTGCCCTTCCCCGTAATGCTGTCCCACTTATAACTGTGCTCTACTTAGCATTCTCAGGGATCATACCTTAATGTTTTCAGTATGT
CTGCGTTCTCCTACTAGATTGTATGTCCCTCAAGAGCATGTTCTGTTTCTCTTCTGTCTGACAGAGCACTATTATACCTGACTTTCAGTA

>5422_5422_1_API5-GANC_API5_chr11_43343686_ENST00000378852_GANC_chr15_42598744_ENST00000318010_length(amino acids)=915AA_BP=187
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKENQEDLGLWEEKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAESHQLKNTGDGDAYRLYNLDVYGYQIYDKMGIYGSVP
YLLAHKLGRTIGIFWLNASETLVEINTEPAVEYTLTQMGPVAAKQKVRSRTHVHWMSESGIIDVFLLTGPTPSDVFKQYSHLTGTQAMPP
LFSLGYHQCRWNYEDEQDVKAVDAGFDEHDIPYDAMWLDIEHTEGKRYFTWDKNRFPNPKRMQELLRSKKRKLVVISDPHIKIDPDYSVY
VKAKDQGFFVKNQEGEDFEGVCWPGLSSYLDFTNPKVREWYSSLFAFPVYQGSTDILFLWNDMNEPSVFRGPEQTMQKNAIHHGNWEHRE
LHNIYGFYHQMATAEGLIKRSKGKERPFVLTRSFFAGSQKYGAVWTGDNTAEWSNLKISIPMLLTLSITGISFCGADIGGFIGNPETELL
VRWYQAGAYQPFFRGHATMNTKRREPWLFGEEHTRLIREAIRERYGLLPYWYSLFYHAHVASQPVMRPLWVEFPDELKTFDMEDEYMLGS
ALLVHPVTEPKATTVDVFLPGSNEVWYDYKTFAHWEGGCTVKIPVALDTIPVFQRGGSVIPIKTTVGKSTGWMTESSYGLRVALSTKGSS
VGELYLDDGHSFQYLHQKQFLHRKFSFCSSVLINSFADQRGHYPSKCVVEKILVLGFRKEPSSVTTHSSDGKDQPVAFTYCAKTSILSLE

--------------------------------------------------------------
>5422_5422_2_API5-GANC_API5_chr11_43343686_ENST00000378852_GANC_chr15_42598744_ENST00000566442_length(transcript)=1921nt_BP=668nt
GCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCGCCGGTCAGGACAAG
GATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGCCACGG
AGCAAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTA
TTCCGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTC
GACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAG
ATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCC
AAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAA
AGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGAAAATCAAGAAGATCTGGGCCTGTGGGAAGAGAAATTTGGAAAATTTGTGG
ATATCAAAGCTAATGGCCCTTCTTCTATTGGTTTGGATTTCTCCTTGCATGGATTTGAGCATCTTTATGGGATCCCACAACATGCAGAAT
CACACCAACTTAAAAATACTGGTGATGGAGATGCTTACCGTCTTTATAACCTGGATGTCTATGGATACCAAATATATGATAAAATGGGCA
TTTATGGTTCAGTACCTTATCTCCTGGCCCACAAACTGGGCAGAACTATAGGTATTTTCTGGCTGAATGCCTCGGAAACACTGGTGGAGA
TCAATACAGAGCCTGCAGTAGAGTACACACTGACCCAGATGGGCCCAGTTGCTGCTAAACAAAAGGTCAGATCTCGCACTCATGTGCACT
GGATGTCAGAGAGTGGCATCATTGATGTTTTTCTGCTGACAGGACCTACACCTTCTGATGTCTTCAAACAGTACTCACACCTTACAGACA
TTGGAGAAAAATAGCTCTCAGTCTGAGGAAGATACTGAGAAAAGGAAAGAAGTTGAAAGCATCTTGAAGAAAAATTCAGATTGGATATGG
GATTGGACAAGTTGGCCAGAAAATATTCCCCACAAGGAGTTCCTCTTTAAAGCACCTGAAGCACGTAGCTACCCAGCATGGAATTTAAAG
CCTGATGAGGAAAGGGGGCATTTTCTCAGCAGAATTTCCAAAGGGTTTTGCTGCTGTCTCATCTGGTGGCCATGGGATTGGGGATCTATA
TTGGAAGGCATCTGACAACTTCTACCAGCACCTTTTGATGAATAATTTGAATCCAGCTTTGTGCGTATAGTGGGGATTTCTATCTGAGCT
TGTGACACAGCTAACTCAGGAGCTGTTATGGTCCTTGGGTGGCTGTTTCACTTGTTTTTATTTGTTCTGTAAATACTGCTTTCCTAATTT
AGTAAAATGAAAGAATAGACACTAAAATCACACTGACCTATACTTATACCTATAGAATCAGTTAATAAGGGTATCAGACTGATTAATATC
TACTGTAACAATTTGGCAGTGAGTTTTCTTTGGATATTAGTATAAATATGTAAGTATCGTTTTAATATATTAGTCATGATATAGCATTTT
AAAAATTATCTGTAACCTGAATTCTGTTAAAACACTTTATATTCCAAAAGAATGAATGACAGTGATATTAAAATCACTACATTAAAGGGT

>5422_5422_2_API5-GANC_API5_chr11_43343686_ENST00000378852_GANC_chr15_42598744_ENST00000566442_length(amino acids)=358AA_BP=187
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKENQEDLGLWEEKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAESHQLKNTGDGDAYRLYNLDVYGYQIYDKMGIYGSVP

--------------------------------------------------------------
>5422_5422_3_API5-GANC_API5_chr11_43343686_ENST00000420461_GANC_chr15_42598744_ENST00000318010_length(transcript)=4225nt_BP=511nt
GACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCGCCGGTCAGG
ACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGC
CACGGAGCAAGTGGGCCAGATTCGACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATAT
ACTAACGCAACTTTTGCAGACAGATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGG
GACTTTAGGTGGGTTGTTCAGCCAAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGAC
TTTACCAGATGAAGTCTTAACAAAGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGAAAATCAAGAAGATCTGGGCCTGTGGGA
AGAGAAATTTGGAAAATTTGTGGATATCAAAGCTAATGGCCCTTCTTCTATTGGTTTGGATTTCTCCTTGCATGGATTTGAGCATCTTTA
TGGGATCCCACAACATGCAGAATCACACCAACTTAAAAATACTGGTGATGGAGATGCTTACCGTCTTTATAACCTGGATGTCTATGGATA
CCAAATATATGATAAAATGGGCATTTATGGTTCAGTACCTTATCTCCTGGCCCACAAACTGGGCAGAACTATAGGTATTTTCTGGCTGAA
TGCCTCGGAAACACTGGTGGAGATCAATACAGAGCCTGCAGTAGAGTACACACTGACCCAGATGGGCCCAGTTGCTGCTAAACAAAAGGT
CAGATCTCGCACTCATGTGCACTGGATGTCAGAGAGTGGCATCATTGATGTTTTTCTGCTGACAGGACCTACACCTTCTGATGTCTTCAA
ACAGTACTCACACCTTACAGGCACACAAGCCATGCCCCCTCTTTTCTCTTTGGGATACCACCAGTGCCGCTGGAACTATGAAGATGAGCA
GGATGTAAAAGCAGTGGATGCAGGGTTTGATGAGCATGACATTCCTTATGATGCCATGTGGCTGGACATAGAGCACACTGAGGGCAAGAG
GTACTTCACCTGGGACAAAAACAGATTCCCAAACCCCAAGAGGATGCAAGAGCTGCTCAGGAGCAAAAAGCGTAAGCTTGTGGTCATCAG
TGATCCCCACATCAAGATTGATCCTGACTACTCAGTATATGTGAAGGCCAAAGATCAGGGCTTCTTTGTGAAGAATCAGGAAGGGGAAGA
CTTTGAAGGGGTGTGTTGGCCAGGTCTCTCCTCTTACCTGGATTTCACCAATCCCAAGGTCAGAGAGTGGTATTCAAGTCTTTTTGCTTT
CCCTGTTTATCAGGGATCTACGGACATCCTCTTCCTTTGGAATGACATGAATGAGCCTTCTGTCTTTAGAGGGCCAGAGCAAACCATGCA
GAAGAATGCCATTCATCATGGCAATTGGGAGCACAGAGAGCTCCACAACATCTACGGTTTTTATCATCAAATGGCTACTGCAGAAGGACT
GATAAAACGATCTAAAGGGAAGGAGAGACCCTTTGTTCTTACACGTTCTTTCTTTGCTGGATCACAAAAGTATGGTGCCGTGTGGACAGG
CGACAACACAGCAGAATGGAGCAACTTGAAAATTTCTATCCCAATGTTACTCACTCTCAGCATTACTGGGATCTCTTTTTGCGGAGCTGA
CATAGGCGGGTTCATTGGGAATCCAGAGACAGAGCTGCTAGTGCGTTGGTACCAGGCTGGAGCCTACCAGCCCTTCTTCCGTGGCCATGC
CACCATGAACACCAAGCGACGAGAGCCCTGGCTCTTTGGGGAGGAACACACCCGACTCATCCGAGAAGCCATCAGAGAGCGCTATGGCCT
CCTGCCATATTGGTATTCTCTGTTCTACCATGCACACGTGGCTTCCCAACCTGTCATGAGGCCTCTGTGGGTAGAGTTCCCTGATGAACT
AAAGACTTTTGATATGGAAGATGAATACATGCTGGGGAGTGCATTATTGGTTCATCCAGTCACAGAACCAAAAGCCACCACAGTTGATGT
GTTTCTTCCAGGATCAAATGAGGTCTGGTATGACTATAAGACATTTGCTCATTGGGAAGGAGGGTGTACTGTAAAGATCCCAGTAGCCTT
GGACACTATTCCAGTGTTTCAGCGAGGTGGAAGTGTGATACCAATAAAGACAACTGTAGGAAAATCCACAGGCTGGATGACTGAATCCTC
CTATGGACTCCGGGTTGCTCTAAGCACTAAGGGTTCTTCAGTGGGTGAGTTATATCTTGATGATGGCCATTCATTCCAATACCTCCACCA
GAAGCAATTTTTGCACAGGAAGTTTTCATTCTGTTCCAGTGTTCTGATCAATAGTTTTGCTGACCAGAGGGGTCATTATCCCAGCAAGTG
TGTGGTGGAGAAGATCTTGGTCTTAGGCTTCAGGAAGGAGCCATCTTCTGTGACTACCCACTCATCTGATGGTAAAGATCAGCCTGTGGC
TTTTACGTATTGTGCCAAAACATCCATCCTGAGCCTGGAGAAGCTCTCACTCAACATTGCCACTGACTGGGAGGTCCGCATCATATGACA
AAGAACTGCCCCTGGTGATGTGAGCAGGGACCTGCCTGCCCCTTTCAACCTTTCCCCTCACCTTTTTTGAGATTTTTGCTGCAATCTGTT
TGCCTTCCCTGAATCAAAATAATCTTTCATTCGTCACCATTATACTAATGAACAATAGATTTCATGTTTCAAAATTTCAGATTTTACATG
TTAAGATGTACTAACAATATTCCTTGTATCAAACATCTCCTTTTCTCCCTGATACATAGCCCTGAGACATTTATAGCGTTCAGGAGTCTT
CTATTGCTTCCATTCCTTCAGCAGGGCTGCGTGGGTCTGTTTTAACGTGGGCCAAGCCTACCTGGGCAGCCCATTTGCCAGGGCTTGCCT
CAGGCCATGCAGCATTGGCGCTCTGGCTGCAGCAGCTGAGTTGCTCAAGGCCAGTGTCCAAGTGGACAGCAGCCTCTGGTACTCCCCCCA
GTTATCTTCCACCCACATGGACTGGGCAGAGCAGCCCTCTTCTGTGTGCACTGCATACGCTGCAGCCGTGGGAGTTATTCTCCCCTAGAG
ATCGACTTGGCAGCACGAAGGATTCTTTTCTCTTTCATGCTTCTCAGGCTCAATAGTTTCTAATTAATCTTAAAATCCATGTCTTTTACA
TTGTTTTTTTAATTAAGTGCTGTTTACTAACCAAATAATATTTATAACATGAGTAAGCTATAATTAATAACAATGAAATAAATACCCATG
TACCCACCACTGGACTTCAGAAGTAGAACTCATGACTGGGACTAGGATGAGGCAAGGGAGACCCTGGCCTTGGGCACAAAATGTAAGGGA
TGCCAAAAAAATACAGTAATCAAAGTAAGTAATATTTCAATCCAATATTTTTAAAAATCAGAATTAATGCAAAAAAAACCATGATGAACA
AAATATTAAAATTTAAAATAAAGACAGGATTAGTATTACTGAGTTTTCCTTTTGTCCCAGGCTCTAATATGGCTTGGCATGGGGCAGAAC
ATTACAACATACCAGTCGTGTCATGGTGCCCAAGGCTCCACAGACCTCAGTGGCTCCCTGCTGCCTGCCACAGCATCTGTTTTAGCAGCC
TCGACTCCTCAGCACTCCTCAGCACACACCTCTTCTTATCAGGCTTCCTCCACTTAGCAACTTGCTAACGGCCACCTCTGTGCCTTCTGA
TCCCTGGGCGCCAATATCCTCCTGCCCTTACCATCCTTCCAGGCCCAACTTAAATCCCACTTTCCCATGAAGCCTAACTGCGTGAACACC
CCTACCCCCATACCCATTAGCAGTGATTTTGCCCTTCCCCGTAATGCTGTCCCACTTATAACTGTGCTCTACTTAGCATTCTCAGGGATC
ATACCTTAATGTTTTCAGTATGTCTGCGTTCTCCTACTAGATTGTATGTCCCTCAAGAGCATGTTCTGTTTCTCTTCTGTCTGACAGAGC

>5422_5422_3_API5-GANC_API5_chr11_43343686_ENST00000420461_GANC_chr15_42598744_ENST00000318010_length(amino acids)=861AA_BP=133
MGLSLTMPTVEELYRNYGILADATEQVGQIRRQAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFS
QILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKENQEDLGLWEEKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAE
SHQLKNTGDGDAYRLYNLDVYGYQIYDKMGIYGSVPYLLAHKLGRTIGIFWLNASETLVEINTEPAVEYTLTQMGPVAAKQKVRSRTHVH
WMSESGIIDVFLLTGPTPSDVFKQYSHLTGTQAMPPLFSLGYHQCRWNYEDEQDVKAVDAGFDEHDIPYDAMWLDIEHTEGKRYFTWDKN
RFPNPKRMQELLRSKKRKLVVISDPHIKIDPDYSVYVKAKDQGFFVKNQEGEDFEGVCWPGLSSYLDFTNPKVREWYSSLFAFPVYQGST
DILFLWNDMNEPSVFRGPEQTMQKNAIHHGNWEHRELHNIYGFYHQMATAEGLIKRSKGKERPFVLTRSFFAGSQKYGAVWTGDNTAEWS
NLKISIPMLLTLSITGISFCGADIGGFIGNPETELLVRWYQAGAYQPFFRGHATMNTKRREPWLFGEEHTRLIREAIRERYGLLPYWYSL
FYHAHVASQPVMRPLWVEFPDELKTFDMEDEYMLGSALLVHPVTEPKATTVDVFLPGSNEVWYDYKTFAHWEGGCTVKIPVALDTIPVFQ
RGGSVIPIKTTVGKSTGWMTESSYGLRVALSTKGSSVGELYLDDGHSFQYLHQKQFLHRKFSFCSSVLINSFADQRGHYPSKCVVEKILV

--------------------------------------------------------------
>5422_5422_4_API5-GANC_API5_chr11_43343686_ENST00000420461_GANC_chr15_42598744_ENST00000566442_length(transcript)=1764nt_BP=511nt
GACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCGCCGGTCAGG
ACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGC
CACGGAGCAAGTGGGCCAGATTCGACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATAT
ACTAACGCAACTTTTGCAGACAGATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGG
GACTTTAGGTGGGTTGTTCAGCCAAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGAC
TTTACCAGATGAAGTCTTAACAAAGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGAAAATCAAGAAGATCTGGGCCTGTGGGA
AGAGAAATTTGGAAAATTTGTGGATATCAAAGCTAATGGCCCTTCTTCTATTGGTTTGGATTTCTCCTTGCATGGATTTGAGCATCTTTA
TGGGATCCCACAACATGCAGAATCACACCAACTTAAAAATACTGGTGATGGAGATGCTTACCGTCTTTATAACCTGGATGTCTATGGATA
CCAAATATATGATAAAATGGGCATTTATGGTTCAGTACCTTATCTCCTGGCCCACAAACTGGGCAGAACTATAGGTATTTTCTGGCTGAA
TGCCTCGGAAACACTGGTGGAGATCAATACAGAGCCTGCAGTAGAGTACACACTGACCCAGATGGGCCCAGTTGCTGCTAAACAAAAGGT
CAGATCTCGCACTCATGTGCACTGGATGTCAGAGAGTGGCATCATTGATGTTTTTCTGCTGACAGGACCTACACCTTCTGATGTCTTCAA
ACAGTACTCACACCTTACAGACATTGGAGAAAAATAGCTCTCAGTCTGAGGAAGATACTGAGAAAAGGAAAGAAGTTGAAAGCATCTTGA
AGAAAAATTCAGATTGGATATGGGATTGGACAAGTTGGCCAGAAAATATTCCCCACAAGGAGTTCCTCTTTAAAGCACCTGAAGCACGTA
GCTACCCAGCATGGAATTTAAAGCCTGATGAGGAAAGGGGGCATTTTCTCAGCAGAATTTCCAAAGGGTTTTGCTGCTGTCTCATCTGGT
GGCCATGGGATTGGGGATCTATATTGGAAGGCATCTGACAACTTCTACCAGCACCTTTTGATGAATAATTTGAATCCAGCTTTGTGCGTA
TAGTGGGGATTTCTATCTGAGCTTGTGACACAGCTAACTCAGGAGCTGTTATGGTCCTTGGGTGGCTGTTTCACTTGTTTTTATTTGTTC
TGTAAATACTGCTTTCCTAATTTAGTAAAATGAAAGAATAGACACTAAAATCACACTGACCTATACTTATACCTATAGAATCAGTTAATA
AGGGTATCAGACTGATTAATATCTACTGTAACAATTTGGCAGTGAGTTTTCTTTGGATATTAGTATAAATATGTAAGTATCGTTTTAATA
TATTAGTCATGATATAGCATTTTAAAAATTATCTGTAACCTGAATTCTGTTAAAACACTTTATATTCCAAAAGAATGAATGACAGTGATA

>5422_5422_4_API5-GANC_API5_chr11_43343686_ENST00000420461_GANC_chr15_42598744_ENST00000566442_length(amino acids)=304AA_BP=133
MGLSLTMPTVEELYRNYGILADATEQVGQIRRQAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFS
QILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKENQEDLGLWEEKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAE
SHQLKNTGDGDAYRLYNLDVYGYQIYDKMGIYGSVPYLLAHKLGRTIGIFWLNASETLVEINTEPAVEYTLTQMGPVAAKQKVRSRTHVH

--------------------------------------------------------------
>5422_5422_5_API5-GANC_API5_chr11_43343686_ENST00000455725_GANC_chr15_42598744_ENST00000318010_length(transcript)=4469nt_BP=755nt
GCAGCCGCGCTGTGCGCGGTGACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGG
CGGCGGTGGCGCCGGTCAGGACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAAT
TATGGCATCCTGGCCGATGCCACGGAGCAAGTGGGCCAGACTCATCCATCTCCCCCAACTCAAAAATGAAACAAAGATGGAGGGAGAACG
GAATTGGGAAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTATTC
CGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTCGAC
GTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAGATG
ACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCCAAA
TACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAAAGG
AAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGAAAATCAAGAAGATCTGGGCCTGTGGGAAGAGAAATTTGGAAAATTTGTGGATA
TCAAAGCTAATGGCCCTTCTTCTATTGGTTTGGATTTCTCCTTGCATGGATTTGAGCATCTTTATGGGATCCCACAACATGCAGAATCAC
ACCAACTTAAAAATACTGGTGATGGAGATGCTTACCGTCTTTATAACCTGGATGTCTATGGATACCAAATATATGATAAAATGGGCATTT
ATGGTTCAGTACCTTATCTCCTGGCCCACAAACTGGGCAGAACTATAGGTATTTTCTGGCTGAATGCCTCGGAAACACTGGTGGAGATCA
ATACAGAGCCTGCAGTAGAGTACACACTGACCCAGATGGGCCCAGTTGCTGCTAAACAAAAGGTCAGATCTCGCACTCATGTGCACTGGA
TGTCAGAGAGTGGCATCATTGATGTTTTTCTGCTGACAGGACCTACACCTTCTGATGTCTTCAAACAGTACTCACACCTTACAGGCACAC
AAGCCATGCCCCCTCTTTTCTCTTTGGGATACCACCAGTGCCGCTGGAACTATGAAGATGAGCAGGATGTAAAAGCAGTGGATGCAGGGT
TTGATGAGCATGACATTCCTTATGATGCCATGTGGCTGGACATAGAGCACACTGAGGGCAAGAGGTACTTCACCTGGGACAAAAACAGAT
TCCCAAACCCCAAGAGGATGCAAGAGCTGCTCAGGAGCAAAAAGCGTAAGCTTGTGGTCATCAGTGATCCCCACATCAAGATTGATCCTG
ACTACTCAGTATATGTGAAGGCCAAAGATCAGGGCTTCTTTGTGAAGAATCAGGAAGGGGAAGACTTTGAAGGGGTGTGTTGGCCAGGTC
TCTCCTCTTACCTGGATTTCACCAATCCCAAGGTCAGAGAGTGGTATTCAAGTCTTTTTGCTTTCCCTGTTTATCAGGGATCTACGGACA
TCCTCTTCCTTTGGAATGACATGAATGAGCCTTCTGTCTTTAGAGGGCCAGAGCAAACCATGCAGAAGAATGCCATTCATCATGGCAATT
GGGAGCACAGAGAGCTCCACAACATCTACGGTTTTTATCATCAAATGGCTACTGCAGAAGGACTGATAAAACGATCTAAAGGGAAGGAGA
GACCCTTTGTTCTTACACGTTCTTTCTTTGCTGGATCACAAAAGTATGGTGCCGTGTGGACAGGCGACAACACAGCAGAATGGAGCAACT
TGAAAATTTCTATCCCAATGTTACTCACTCTCAGCATTACTGGGATCTCTTTTTGCGGAGCTGACATAGGCGGGTTCATTGGGAATCCAG
AGACAGAGCTGCTAGTGCGTTGGTACCAGGCTGGAGCCTACCAGCCCTTCTTCCGTGGCCATGCCACCATGAACACCAAGCGACGAGAGC
CCTGGCTCTTTGGGGAGGAACACACCCGACTCATCCGAGAAGCCATCAGAGAGCGCTATGGCCTCCTGCCATATTGGTATTCTCTGTTCT
ACCATGCACACGTGGCTTCCCAACCTGTCATGAGGCCTCTGTGGGTAGAGTTCCCTGATGAACTAAAGACTTTTGATATGGAAGATGAAT
ACATGCTGGGGAGTGCATTATTGGTTCATCCAGTCACAGAACCAAAAGCCACCACAGTTGATGTGTTTCTTCCAGGATCAAATGAGGTCT
GGTATGACTATAAGACATTTGCTCATTGGGAAGGAGGGTGTACTGTAAAGATCCCAGTAGCCTTGGACACTATTCCAGTGTTTCAGCGAG
GTGGAAGTGTGATACCAATAAAGACAACTGTAGGAAAATCCACAGGCTGGATGACTGAATCCTCCTATGGACTCCGGGTTGCTCTAAGCA
CTAAGGGTTCTTCAGTGGGTGAGTTATATCTTGATGATGGCCATTCATTCCAATACCTCCACCAGAAGCAATTTTTGCACAGGAAGTTTT
CATTCTGTTCCAGTGTTCTGATCAATAGTTTTGCTGACCAGAGGGGTCATTATCCCAGCAAGTGTGTGGTGGAGAAGATCTTGGTCTTAG
GCTTCAGGAAGGAGCCATCTTCTGTGACTACCCACTCATCTGATGGTAAAGATCAGCCTGTGGCTTTTACGTATTGTGCCAAAACATCCA
TCCTGAGCCTGGAGAAGCTCTCACTCAACATTGCCACTGACTGGGAGGTCCGCATCATATGACAAAGAACTGCCCCTGGTGATGTGAGCA
GGGACCTGCCTGCCCCTTTCAACCTTTCCCCTCACCTTTTTTGAGATTTTTGCTGCAATCTGTTTGCCTTCCCTGAATCAAAATAATCTT
TCATTCGTCACCATTATACTAATGAACAATAGATTTCATGTTTCAAAATTTCAGATTTTACATGTTAAGATGTACTAACAATATTCCTTG
TATCAAACATCTCCTTTTCTCCCTGATACATAGCCCTGAGACATTTATAGCGTTCAGGAGTCTTCTATTGCTTCCATTCCTTCAGCAGGG
CTGCGTGGGTCTGTTTTAACGTGGGCCAAGCCTACCTGGGCAGCCCATTTGCCAGGGCTTGCCTCAGGCCATGCAGCATTGGCGCTCTGG
CTGCAGCAGCTGAGTTGCTCAAGGCCAGTGTCCAAGTGGACAGCAGCCTCTGGTACTCCCCCCAGTTATCTTCCACCCACATGGACTGGG
CAGAGCAGCCCTCTTCTGTGTGCACTGCATACGCTGCAGCCGTGGGAGTTATTCTCCCCTAGAGATCGACTTGGCAGCACGAAGGATTCT
TTTCTCTTTCATGCTTCTCAGGCTCAATAGTTTCTAATTAATCTTAAAATCCATGTCTTTTACATTGTTTTTTTAATTAAGTGCTGTTTA
CTAACCAAATAATATTTATAACATGAGTAAGCTATAATTAATAACAATGAAATAAATACCCATGTACCCACCACTGGACTTCAGAAGTAG
AACTCATGACTGGGACTAGGATGAGGCAAGGGAGACCCTGGCCTTGGGCACAAAATGTAAGGGATGCCAAAAAAATACAGTAATCAAAGT
AAGTAATATTTCAATCCAATATTTTTAAAAATCAGAATTAATGCAAAAAAAACCATGATGAACAAAATATTAAAATTTAAAATAAAGACA
GGATTAGTATTACTGAGTTTTCCTTTTGTCCCAGGCTCTAATATGGCTTGGCATGGGGCAGAACATTACAACATACCAGTCGTGTCATGG
TGCCCAAGGCTCCACAGACCTCAGTGGCTCCCTGCTGCCTGCCACAGCATCTGTTTTAGCAGCCTCGACTCCTCAGCACTCCTCAGCACA
CACCTCTTCTTATCAGGCTTCCTCCACTTAGCAACTTGCTAACGGCCACCTCTGTGCCTTCTGATCCCTGGGCGCCAATATCCTCCTGCC
CTTACCATCCTTCCAGGCCCAACTTAAATCCCACTTTCCCATGAAGCCTAACTGCGTGAACACCCCTACCCCCATACCCATTAGCAGTGA
TTTTGCCCTTCCCCGTAATGCTGTCCCACTTATAACTGTGCTCTACTTAGCATTCTCAGGGATCATACCTTAATGTTTTCAGTATGTCTG
CGTTCTCCTACTAGATTGTATGTCCCTCAAGAGCATGTTCTGTTTCTCTTCTGTCTGACAGAGCACTATTATACCTGACTTTCAGTAACT

>5422_5422_5_API5-GANC_API5_chr11_43343686_ENST00000455725_GANC_chr15_42598744_ENST00000318010_length(amino acids)=898AA_BP=170
MKQRWRENGIGKHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADI
LTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKENQEDLGLWE
EKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAESHQLKNTGDGDAYRLYNLDVYGYQIYDKMGIYGSVPYLLAHKLGRTIGIFWLN
ASETLVEINTEPAVEYTLTQMGPVAAKQKVRSRTHVHWMSESGIIDVFLLTGPTPSDVFKQYSHLTGTQAMPPLFSLGYHQCRWNYEDEQ
DVKAVDAGFDEHDIPYDAMWLDIEHTEGKRYFTWDKNRFPNPKRMQELLRSKKRKLVVISDPHIKIDPDYSVYVKAKDQGFFVKNQEGED
FEGVCWPGLSSYLDFTNPKVREWYSSLFAFPVYQGSTDILFLWNDMNEPSVFRGPEQTMQKNAIHHGNWEHRELHNIYGFYHQMATAEGL
IKRSKGKERPFVLTRSFFAGSQKYGAVWTGDNTAEWSNLKISIPMLLTLSITGISFCGADIGGFIGNPETELLVRWYQAGAYQPFFRGHA
TMNTKRREPWLFGEEHTRLIREAIRERYGLLPYWYSLFYHAHVASQPVMRPLWVEFPDELKTFDMEDEYMLGSALLVHPVTEPKATTVDV
FLPGSNEVWYDYKTFAHWEGGCTVKIPVALDTIPVFQRGGSVIPIKTTVGKSTGWMTESSYGLRVALSTKGSSVGELYLDDGHSFQYLHQ

--------------------------------------------------------------
>5422_5422_6_API5-GANC_API5_chr11_43343686_ENST00000455725_GANC_chr15_42598744_ENST00000566442_length(transcript)=2008nt_BP=755nt
GCAGCCGCGCTGTGCGCGGTGACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGG
CGGCGGTGGCGCCGGTCAGGACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAAT
TATGGCATCCTGGCCGATGCCACGGAGCAAGTGGGCCAGACTCATCCATCTCCCCCAACTCAAAAATGAAACAAAGATGGAGGGAGAACG
GAATTGGGAAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTATTC
CGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTCGAC
GTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAGATG
ACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCCAAA
TACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAAAGG
AAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGAAAATCAAGAAGATCTGGGCCTGTGGGAAGAGAAATTTGGAAAATTTGTGGATA
TCAAAGCTAATGGCCCTTCTTCTATTGGTTTGGATTTCTCCTTGCATGGATTTGAGCATCTTTATGGGATCCCACAACATGCAGAATCAC
ACCAACTTAAAAATACTGGTGATGGAGATGCTTACCGTCTTTATAACCTGGATGTCTATGGATACCAAATATATGATAAAATGGGCATTT
ATGGTTCAGTACCTTATCTCCTGGCCCACAAACTGGGCAGAACTATAGGTATTTTCTGGCTGAATGCCTCGGAAACACTGGTGGAGATCA
ATACAGAGCCTGCAGTAGAGTACACACTGACCCAGATGGGCCCAGTTGCTGCTAAACAAAAGGTCAGATCTCGCACTCATGTGCACTGGA
TGTCAGAGAGTGGCATCATTGATGTTTTTCTGCTGACAGGACCTACACCTTCTGATGTCTTCAAACAGTACTCACACCTTACAGACATTG
GAGAAAAATAGCTCTCAGTCTGAGGAAGATACTGAGAAAAGGAAAGAAGTTGAAAGCATCTTGAAGAAAAATTCAGATTGGATATGGGAT
TGGACAAGTTGGCCAGAAAATATTCCCCACAAGGAGTTCCTCTTTAAAGCACCTGAAGCACGTAGCTACCCAGCATGGAATTTAAAGCCT
GATGAGGAAAGGGGGCATTTTCTCAGCAGAATTTCCAAAGGGTTTTGCTGCTGTCTCATCTGGTGGCCATGGGATTGGGGATCTATATTG
GAAGGCATCTGACAACTTCTACCAGCACCTTTTGATGAATAATTTGAATCCAGCTTTGTGCGTATAGTGGGGATTTCTATCTGAGCTTGT
GACACAGCTAACTCAGGAGCTGTTATGGTCCTTGGGTGGCTGTTTCACTTGTTTTTATTTGTTCTGTAAATACTGCTTTCCTAATTTAGT
AAAATGAAAGAATAGACACTAAAATCACACTGACCTATACTTATACCTATAGAATCAGTTAATAAGGGTATCAGACTGATTAATATCTAC
TGTAACAATTTGGCAGTGAGTTTTCTTTGGATATTAGTATAAATATGTAAGTATCGTTTTAATATATTAGTCATGATATAGCATTTTAAA
AATTATCTGTAACCTGAATTCTGTTAAAACACTTTATATTCCAAAAGAATGAATGACAGTGATATTAAAATCACTACATTAAAGGGTTTG

>5422_5422_6_API5-GANC_API5_chr11_43343686_ENST00000455725_GANC_chr15_42598744_ENST00000566442_length(amino acids)=341AA_BP=170
MKQRWRENGIGKHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADI
LTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKENQEDLGLWE
EKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAESHQLKNTGDGDAYRLYNLDVYGYQIYDKMGIYGSVPYLLAHKLGRTIGIFWLN

--------------------------------------------------------------
>5422_5422_7_API5-GANC_API5_chr11_43343686_ENST00000531273_GANC_chr15_42598744_ENST00000318010_length(transcript)=4396nt_BP=682nt
GTGCGCGGTGACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCG
CCGGTCAGGACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCT
GGCCGATGCCACGGAGCAAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATT
AGCAGCTCAATTTATTCCGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGA
AGATGTATCTATTCGACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCA
ACTTTTGCAGACAGATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGG
TGGGTTGTTCAGCCAAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGA
TGAAGTCTTAACAAAGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGAAAATCAAGAAGATCTGGGCCTGTGGGAAGAGAAATT
TGGAAAATTTGTGGATATCAAAGCTAATGGCCCTTCTTCTATTGGTTTGGATTTCTCCTTGCATGGATTTGAGCATCTTTATGGGATCCC
ACAACATGCAGAATCACACCAACTTAAAAATACTGGTGATGGAGATGCTTACCGTCTTTATAACCTGGATGTCTATGGATACCAAATATA
TGATAAAATGGGCATTTATGGTTCAGTACCTTATCTCCTGGCCCACAAACTGGGCAGAACTATAGGTATTTTCTGGCTGAATGCCTCGGA
AACACTGGTGGAGATCAATACAGAGCCTGCAGTAGAGTACACACTGACCCAGATGGGCCCAGTTGCTGCTAAACAAAAGGTCAGATCTCG
CACTCATGTGCACTGGATGTCAGAGAGTGGCATCATTGATGTTTTTCTGCTGACAGGACCTACACCTTCTGATGTCTTCAAACAGTACTC
ACACCTTACAGGCACACAAGCCATGCCCCCTCTTTTCTCTTTGGGATACCACCAGTGCCGCTGGAACTATGAAGATGAGCAGGATGTAAA
AGCAGTGGATGCAGGGTTTGATGAGCATGACATTCCTTATGATGCCATGTGGCTGGACATAGAGCACACTGAGGGCAAGAGGTACTTCAC
CTGGGACAAAAACAGATTCCCAAACCCCAAGAGGATGCAAGAGCTGCTCAGGAGCAAAAAGCGTAAGCTTGTGGTCATCAGTGATCCCCA
CATCAAGATTGATCCTGACTACTCAGTATATGTGAAGGCCAAAGATCAGGGCTTCTTTGTGAAGAATCAGGAAGGGGAAGACTTTGAAGG
GGTGTGTTGGCCAGGTCTCTCCTCTTACCTGGATTTCACCAATCCCAAGGTCAGAGAGTGGTATTCAAGTCTTTTTGCTTTCCCTGTTTA
TCAGGGATCTACGGACATCCTCTTCCTTTGGAATGACATGAATGAGCCTTCTGTCTTTAGAGGGCCAGAGCAAACCATGCAGAAGAATGC
CATTCATCATGGCAATTGGGAGCACAGAGAGCTCCACAACATCTACGGTTTTTATCATCAAATGGCTACTGCAGAAGGACTGATAAAACG
ATCTAAAGGGAAGGAGAGACCCTTTGTTCTTACACGTTCTTTCTTTGCTGGATCACAAAAGTATGGTGCCGTGTGGACAGGCGACAACAC
AGCAGAATGGAGCAACTTGAAAATTTCTATCCCAATGTTACTCACTCTCAGCATTACTGGGATCTCTTTTTGCGGAGCTGACATAGGCGG
GTTCATTGGGAATCCAGAGACAGAGCTGCTAGTGCGTTGGTACCAGGCTGGAGCCTACCAGCCCTTCTTCCGTGGCCATGCCACCATGAA
CACCAAGCGACGAGAGCCCTGGCTCTTTGGGGAGGAACACACCCGACTCATCCGAGAAGCCATCAGAGAGCGCTATGGCCTCCTGCCATA
TTGGTATTCTCTGTTCTACCATGCACACGTGGCTTCCCAACCTGTCATGAGGCCTCTGTGGGTAGAGTTCCCTGATGAACTAAAGACTTT
TGATATGGAAGATGAATACATGCTGGGGAGTGCATTATTGGTTCATCCAGTCACAGAACCAAAAGCCACCACAGTTGATGTGTTTCTTCC
AGGATCAAATGAGGTCTGGTATGACTATAAGACATTTGCTCATTGGGAAGGAGGGTGTACTGTAAAGATCCCAGTAGCCTTGGACACTAT
TCCAGTGTTTCAGCGAGGTGGAAGTGTGATACCAATAAAGACAACTGTAGGAAAATCCACAGGCTGGATGACTGAATCCTCCTATGGACT
CCGGGTTGCTCTAAGCACTAAGGGTTCTTCAGTGGGTGAGTTATATCTTGATGATGGCCATTCATTCCAATACCTCCACCAGAAGCAATT
TTTGCACAGGAAGTTTTCATTCTGTTCCAGTGTTCTGATCAATAGTTTTGCTGACCAGAGGGGTCATTATCCCAGCAAGTGTGTGGTGGA
GAAGATCTTGGTCTTAGGCTTCAGGAAGGAGCCATCTTCTGTGACTACCCACTCATCTGATGGTAAAGATCAGCCTGTGGCTTTTACGTA
TTGTGCCAAAACATCCATCCTGAGCCTGGAGAAGCTCTCACTCAACATTGCCACTGACTGGGAGGTCCGCATCATATGACAAAGAACTGC
CCCTGGTGATGTGAGCAGGGACCTGCCTGCCCCTTTCAACCTTTCCCCTCACCTTTTTTGAGATTTTTGCTGCAATCTGTTTGCCTTCCC
TGAATCAAAATAATCTTTCATTCGTCACCATTATACTAATGAACAATAGATTTCATGTTTCAAAATTTCAGATTTTACATGTTAAGATGT
ACTAACAATATTCCTTGTATCAAACATCTCCTTTTCTCCCTGATACATAGCCCTGAGACATTTATAGCGTTCAGGAGTCTTCTATTGCTT
CCATTCCTTCAGCAGGGCTGCGTGGGTCTGTTTTAACGTGGGCCAAGCCTACCTGGGCAGCCCATTTGCCAGGGCTTGCCTCAGGCCATG
CAGCATTGGCGCTCTGGCTGCAGCAGCTGAGTTGCTCAAGGCCAGTGTCCAAGTGGACAGCAGCCTCTGGTACTCCCCCCAGTTATCTTC
CACCCACATGGACTGGGCAGAGCAGCCCTCTTCTGTGTGCACTGCATACGCTGCAGCCGTGGGAGTTATTCTCCCCTAGAGATCGACTTG
GCAGCACGAAGGATTCTTTTCTCTTTCATGCTTCTCAGGCTCAATAGTTTCTAATTAATCTTAAAATCCATGTCTTTTACATTGTTTTTT
TAATTAAGTGCTGTTTACTAACCAAATAATATTTATAACATGAGTAAGCTATAATTAATAACAATGAAATAAATACCCATGTACCCACCA
CTGGACTTCAGAAGTAGAACTCATGACTGGGACTAGGATGAGGCAAGGGAGACCCTGGCCTTGGGCACAAAATGTAAGGGATGCCAAAAA
AATACAGTAATCAAAGTAAGTAATATTTCAATCCAATATTTTTAAAAATCAGAATTAATGCAAAAAAAACCATGATGAACAAAATATTAA
AATTTAAAATAAAGACAGGATTAGTATTACTGAGTTTTCCTTTTGTCCCAGGCTCTAATATGGCTTGGCATGGGGCAGAACATTACAACA
TACCAGTCGTGTCATGGTGCCCAAGGCTCCACAGACCTCAGTGGCTCCCTGCTGCCTGCCACAGCATCTGTTTTAGCAGCCTCGACTCCT
CAGCACTCCTCAGCACACACCTCTTCTTATCAGGCTTCCTCCACTTAGCAACTTGCTAACGGCCACCTCTGTGCCTTCTGATCCCTGGGC
GCCAATATCCTCCTGCCCTTACCATCCTTCCAGGCCCAACTTAAATCCCACTTTCCCATGAAGCCTAACTGCGTGAACACCCCTACCCCC
ATACCCATTAGCAGTGATTTTGCCCTTCCCCGTAATGCTGTCCCACTTATAACTGTGCTCTACTTAGCATTCTCAGGGATCATACCTTAA
TGTTTTCAGTATGTCTGCGTTCTCCTACTAGATTGTATGTCCCTCAAGAGCATGTTCTGTTTCTCTTCTGTCTGACAGAGCACTATTATA

>5422_5422_7_API5-GANC_API5_chr11_43343686_ENST00000531273_GANC_chr15_42598744_ENST00000318010_length(amino acids)=915AA_BP=187
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKENQEDLGLWEEKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAESHQLKNTGDGDAYRLYNLDVYGYQIYDKMGIYGSVP
YLLAHKLGRTIGIFWLNASETLVEINTEPAVEYTLTQMGPVAAKQKVRSRTHVHWMSESGIIDVFLLTGPTPSDVFKQYSHLTGTQAMPP
LFSLGYHQCRWNYEDEQDVKAVDAGFDEHDIPYDAMWLDIEHTEGKRYFTWDKNRFPNPKRMQELLRSKKRKLVVISDPHIKIDPDYSVY
VKAKDQGFFVKNQEGEDFEGVCWPGLSSYLDFTNPKVREWYSSLFAFPVYQGSTDILFLWNDMNEPSVFRGPEQTMQKNAIHHGNWEHRE
LHNIYGFYHQMATAEGLIKRSKGKERPFVLTRSFFAGSQKYGAVWTGDNTAEWSNLKISIPMLLTLSITGISFCGADIGGFIGNPETELL
VRWYQAGAYQPFFRGHATMNTKRREPWLFGEEHTRLIREAIRERYGLLPYWYSLFYHAHVASQPVMRPLWVEFPDELKTFDMEDEYMLGS
ALLVHPVTEPKATTVDVFLPGSNEVWYDYKTFAHWEGGCTVKIPVALDTIPVFQRGGSVIPIKTTVGKSTGWMTESSYGLRVALSTKGSS
VGELYLDDGHSFQYLHQKQFLHRKFSFCSSVLINSFADQRGHYPSKCVVEKILVLGFRKEPSSVTTHSSDGKDQPVAFTYCAKTSILSLE

--------------------------------------------------------------
>5422_5422_8_API5-GANC_API5_chr11_43343686_ENST00000531273_GANC_chr15_42598744_ENST00000566442_length(transcript)=1935nt_BP=682nt
GTGCGCGGTGACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCG
CCGGTCAGGACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCT
GGCCGATGCCACGGAGCAAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATT
AGCAGCTCAATTTATTCCGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGA
AGATGTATCTATTCGACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCA
ACTTTTGCAGACAGATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGG
TGGGTTGTTCAGCCAAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGA
TGAAGTCTTAACAAAGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGAAAATCAAGAAGATCTGGGCCTGTGGGAAGAGAAATT
TGGAAAATTTGTGGATATCAAAGCTAATGGCCCTTCTTCTATTGGTTTGGATTTCTCCTTGCATGGATTTGAGCATCTTTATGGGATCCC
ACAACATGCAGAATCACACCAACTTAAAAATACTGGTGATGGAGATGCTTACCGTCTTTATAACCTGGATGTCTATGGATACCAAATATA
TGATAAAATGGGCATTTATGGTTCAGTACCTTATCTCCTGGCCCACAAACTGGGCAGAACTATAGGTATTTTCTGGCTGAATGCCTCGGA
AACACTGGTGGAGATCAATACAGAGCCTGCAGTAGAGTACACACTGACCCAGATGGGCCCAGTTGCTGCTAAACAAAAGGTCAGATCTCG
CACTCATGTGCACTGGATGTCAGAGAGTGGCATCATTGATGTTTTTCTGCTGACAGGACCTACACCTTCTGATGTCTTCAAACAGTACTC
ACACCTTACAGACATTGGAGAAAAATAGCTCTCAGTCTGAGGAAGATACTGAGAAAAGGAAAGAAGTTGAAAGCATCTTGAAGAAAAATT
CAGATTGGATATGGGATTGGACAAGTTGGCCAGAAAATATTCCCCACAAGGAGTTCCTCTTTAAAGCACCTGAAGCACGTAGCTACCCAG
CATGGAATTTAAAGCCTGATGAGGAAAGGGGGCATTTTCTCAGCAGAATTTCCAAAGGGTTTTGCTGCTGTCTCATCTGGTGGCCATGGG
ATTGGGGATCTATATTGGAAGGCATCTGACAACTTCTACCAGCACCTTTTGATGAATAATTTGAATCCAGCTTTGTGCGTATAGTGGGGA
TTTCTATCTGAGCTTGTGACACAGCTAACTCAGGAGCTGTTATGGTCCTTGGGTGGCTGTTTCACTTGTTTTTATTTGTTCTGTAAATAC
TGCTTTCCTAATTTAGTAAAATGAAAGAATAGACACTAAAATCACACTGACCTATACTTATACCTATAGAATCAGTTAATAAGGGTATCA
GACTGATTAATATCTACTGTAACAATTTGGCAGTGAGTTTTCTTTGGATATTAGTATAAATATGTAAGTATCGTTTTAATATATTAGTCA
TGATATAGCATTTTAAAAATTATCTGTAACCTGAATTCTGTTAAAACACTTTATATTCCAAAAGAATGAATGACAGTGATATTAAAATCA

>5422_5422_8_API5-GANC_API5_chr11_43343686_ENST00000531273_GANC_chr15_42598744_ENST00000566442_length(amino acids)=358AA_BP=187
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKENQEDLGLWEEKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAESHQLKNTGDGDAYRLYNLDVYGYQIYDKMGIYGSVP

--------------------------------------------------------------
>5422_5422_9_API5-GANC_API5_chr11_43343686_ENST00000534600_GANC_chr15_42598744_ENST00000318010_length(transcript)=4289nt_BP=575nt
AGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGCCACGGAGC
AAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTATTC
CGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTCGAC
GTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAGATG
ACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCCAAA
TACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAAAGG
AAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGAAAATCAAGAAGATCTGGGCCTGTGGGAAGAGAAATTTGGAAAATTTGTGGATA
TCAAAGCTAATGGCCCTTCTTCTATTGGTTTGGATTTCTCCTTGCATGGATTTGAGCATCTTTATGGGATCCCACAACATGCAGAATCAC
ACCAACTTAAAAATACTGGTGATGGAGATGCTTACCGTCTTTATAACCTGGATGTCTATGGATACCAAATATATGATAAAATGGGCATTT
ATGGTTCAGTACCTTATCTCCTGGCCCACAAACTGGGCAGAACTATAGGTATTTTCTGGCTGAATGCCTCGGAAACACTGGTGGAGATCA
ATACAGAGCCTGCAGTAGAGTACACACTGACCCAGATGGGCCCAGTTGCTGCTAAACAAAAGGTCAGATCTCGCACTCATGTGCACTGGA
TGTCAGAGAGTGGCATCATTGATGTTTTTCTGCTGACAGGACCTACACCTTCTGATGTCTTCAAACAGTACTCACACCTTACAGGCACAC
AAGCCATGCCCCCTCTTTTCTCTTTGGGATACCACCAGTGCCGCTGGAACTATGAAGATGAGCAGGATGTAAAAGCAGTGGATGCAGGGT
TTGATGAGCATGACATTCCTTATGATGCCATGTGGCTGGACATAGAGCACACTGAGGGCAAGAGGTACTTCACCTGGGACAAAAACAGAT
TCCCAAACCCCAAGAGGATGCAAGAGCTGCTCAGGAGCAAAAAGCGTAAGCTTGTGGTCATCAGTGATCCCCACATCAAGATTGATCCTG
ACTACTCAGTATATGTGAAGGCCAAAGATCAGGGCTTCTTTGTGAAGAATCAGGAAGGGGAAGACTTTGAAGGGGTGTGTTGGCCAGGTC
TCTCCTCTTACCTGGATTTCACCAATCCCAAGGTCAGAGAGTGGTATTCAAGTCTTTTTGCTTTCCCTGTTTATCAGGGATCTACGGACA
TCCTCTTCCTTTGGAATGACATGAATGAGCCTTCTGTCTTTAGAGGGCCAGAGCAAACCATGCAGAAGAATGCCATTCATCATGGCAATT
GGGAGCACAGAGAGCTCCACAACATCTACGGTTTTTATCATCAAATGGCTACTGCAGAAGGACTGATAAAACGATCTAAAGGGAAGGAGA
GACCCTTTGTTCTTACACGTTCTTTCTTTGCTGGATCACAAAAGTATGGTGCCGTGTGGACAGGCGACAACACAGCAGAATGGAGCAACT
TGAAAATTTCTATCCCAATGTTACTCACTCTCAGCATTACTGGGATCTCTTTTTGCGGAGCTGACATAGGCGGGTTCATTGGGAATCCAG
AGACAGAGCTGCTAGTGCGTTGGTACCAGGCTGGAGCCTACCAGCCCTTCTTCCGTGGCCATGCCACCATGAACACCAAGCGACGAGAGC
CCTGGCTCTTTGGGGAGGAACACACCCGACTCATCCGAGAAGCCATCAGAGAGCGCTATGGCCTCCTGCCATATTGGTATTCTCTGTTCT
ACCATGCACACGTGGCTTCCCAACCTGTCATGAGGCCTCTGTGGGTAGAGTTCCCTGATGAACTAAAGACTTTTGATATGGAAGATGAAT
ACATGCTGGGGAGTGCATTATTGGTTCATCCAGTCACAGAACCAAAAGCCACCACAGTTGATGTGTTTCTTCCAGGATCAAATGAGGTCT
GGTATGACTATAAGACATTTGCTCATTGGGAAGGAGGGTGTACTGTAAAGATCCCAGTAGCCTTGGACACTATTCCAGTGTTTCAGCGAG
GTGGAAGTGTGATACCAATAAAGACAACTGTAGGAAAATCCACAGGCTGGATGACTGAATCCTCCTATGGACTCCGGGTTGCTCTAAGCA
CTAAGGGTTCTTCAGTGGGTGAGTTATATCTTGATGATGGCCATTCATTCCAATACCTCCACCAGAAGCAATTTTTGCACAGGAAGTTTT
CATTCTGTTCCAGTGTTCTGATCAATAGTTTTGCTGACCAGAGGGGTCATTATCCCAGCAAGTGTGTGGTGGAGAAGATCTTGGTCTTAG
GCTTCAGGAAGGAGCCATCTTCTGTGACTACCCACTCATCTGATGGTAAAGATCAGCCTGTGGCTTTTACGTATTGTGCCAAAACATCCA
TCCTGAGCCTGGAGAAGCTCTCACTCAACATTGCCACTGACTGGGAGGTCCGCATCATATGACAAAGAACTGCCCCTGGTGATGTGAGCA
GGGACCTGCCTGCCCCTTTCAACCTTTCCCCTCACCTTTTTTGAGATTTTTGCTGCAATCTGTTTGCCTTCCCTGAATCAAAATAATCTT
TCATTCGTCACCATTATACTAATGAACAATAGATTTCATGTTTCAAAATTTCAGATTTTACATGTTAAGATGTACTAACAATATTCCTTG
TATCAAACATCTCCTTTTCTCCCTGATACATAGCCCTGAGACATTTATAGCGTTCAGGAGTCTTCTATTGCTTCCATTCCTTCAGCAGGG
CTGCGTGGGTCTGTTTTAACGTGGGCCAAGCCTACCTGGGCAGCCCATTTGCCAGGGCTTGCCTCAGGCCATGCAGCATTGGCGCTCTGG
CTGCAGCAGCTGAGTTGCTCAAGGCCAGTGTCCAAGTGGACAGCAGCCTCTGGTACTCCCCCCAGTTATCTTCCACCCACATGGACTGGG
CAGAGCAGCCCTCTTCTGTGTGCACTGCATACGCTGCAGCCGTGGGAGTTATTCTCCCCTAGAGATCGACTTGGCAGCACGAAGGATTCT
TTTCTCTTTCATGCTTCTCAGGCTCAATAGTTTCTAATTAATCTTAAAATCCATGTCTTTTACATTGTTTTTTTAATTAAGTGCTGTTTA
CTAACCAAATAATATTTATAACATGAGTAAGCTATAATTAATAACAATGAAATAAATACCCATGTACCCACCACTGGACTTCAGAAGTAG
AACTCATGACTGGGACTAGGATGAGGCAAGGGAGACCCTGGCCTTGGGCACAAAATGTAAGGGATGCCAAAAAAATACAGTAATCAAAGT
AAGTAATATTTCAATCCAATATTTTTAAAAATCAGAATTAATGCAAAAAAAACCATGATGAACAAAATATTAAAATTTAAAATAAAGACA
GGATTAGTATTACTGAGTTTTCCTTTTGTCCCAGGCTCTAATATGGCTTGGCATGGGGCAGAACATTACAACATACCAGTCGTGTCATGG
TGCCCAAGGCTCCACAGACCTCAGTGGCTCCCTGCTGCCTGCCACAGCATCTGTTTTAGCAGCCTCGACTCCTCAGCACTCCTCAGCACA
CACCTCTTCTTATCAGGCTTCCTCCACTTAGCAACTTGCTAACGGCCACCTCTGTGCCTTCTGATCCCTGGGCGCCAATATCCTCCTGCC
CTTACCATCCTTCCAGGCCCAACTTAAATCCCACTTTCCCATGAAGCCTAACTGCGTGAACACCCCTACCCCCATACCCATTAGCAGTGA
TTTTGCCCTTCCCCGTAATGCTGTCCCACTTATAACTGTGCTCTACTTAGCATTCTCAGGGATCATACCTTAATGTTTTCAGTATGTCTG
CGTTCTCCTACTAGATTGTATGTCCCTCAAGAGCATGTTCTGTTTCTCTTCTGTCTGACAGAGCACTATTATACCTGACTTTCAGTAACT

>5422_5422_9_API5-GANC_API5_chr11_43343686_ENST00000534600_GANC_chr15_42598744_ENST00000318010_length(amino acids)=915AA_BP=187
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKENQEDLGLWEEKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAESHQLKNTGDGDAYRLYNLDVYGYQIYDKMGIYGSVP
YLLAHKLGRTIGIFWLNASETLVEINTEPAVEYTLTQMGPVAAKQKVRSRTHVHWMSESGIIDVFLLTGPTPSDVFKQYSHLTGTQAMPP
LFSLGYHQCRWNYEDEQDVKAVDAGFDEHDIPYDAMWLDIEHTEGKRYFTWDKNRFPNPKRMQELLRSKKRKLVVISDPHIKIDPDYSVY
VKAKDQGFFVKNQEGEDFEGVCWPGLSSYLDFTNPKVREWYSSLFAFPVYQGSTDILFLWNDMNEPSVFRGPEQTMQKNAIHHGNWEHRE
LHNIYGFYHQMATAEGLIKRSKGKERPFVLTRSFFAGSQKYGAVWTGDNTAEWSNLKISIPMLLTLSITGISFCGADIGGFIGNPETELL
VRWYQAGAYQPFFRGHATMNTKRREPWLFGEEHTRLIREAIRERYGLLPYWYSLFYHAHVASQPVMRPLWVEFPDELKTFDMEDEYMLGS
ALLVHPVTEPKATTVDVFLPGSNEVWYDYKTFAHWEGGCTVKIPVALDTIPVFQRGGSVIPIKTTVGKSTGWMTESSYGLRVALSTKGSS
VGELYLDDGHSFQYLHQKQFLHRKFSFCSSVLINSFADQRGHYPSKCVVEKILVLGFRKEPSSVTTHSSDGKDQPVAFTYCAKTSILSLE

--------------------------------------------------------------
>5422_5422_10_API5-GANC_API5_chr11_43343686_ENST00000534600_GANC_chr15_42598744_ENST00000566442_length(transcript)=1828nt_BP=575nt
AGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGCCACGGAGC
AAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTATTC
CGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTCGAC
GTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAGATG
ACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCCAAA
TACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAAAGG
AAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGAAAATCAAGAAGATCTGGGCCTGTGGGAAGAGAAATTTGGAAAATTTGTGGATA
TCAAAGCTAATGGCCCTTCTTCTATTGGTTTGGATTTCTCCTTGCATGGATTTGAGCATCTTTATGGGATCCCACAACATGCAGAATCAC
ACCAACTTAAAAATACTGGTGATGGAGATGCTTACCGTCTTTATAACCTGGATGTCTATGGATACCAAATATATGATAAAATGGGCATTT
ATGGTTCAGTACCTTATCTCCTGGCCCACAAACTGGGCAGAACTATAGGTATTTTCTGGCTGAATGCCTCGGAAACACTGGTGGAGATCA
ATACAGAGCCTGCAGTAGAGTACACACTGACCCAGATGGGCCCAGTTGCTGCTAAACAAAAGGTCAGATCTCGCACTCATGTGCACTGGA
TGTCAGAGAGTGGCATCATTGATGTTTTTCTGCTGACAGGACCTACACCTTCTGATGTCTTCAAACAGTACTCACACCTTACAGACATTG
GAGAAAAATAGCTCTCAGTCTGAGGAAGATACTGAGAAAAGGAAAGAAGTTGAAAGCATCTTGAAGAAAAATTCAGATTGGATATGGGAT
TGGACAAGTTGGCCAGAAAATATTCCCCACAAGGAGTTCCTCTTTAAAGCACCTGAAGCACGTAGCTACCCAGCATGGAATTTAAAGCCT
GATGAGGAAAGGGGGCATTTTCTCAGCAGAATTTCCAAAGGGTTTTGCTGCTGTCTCATCTGGTGGCCATGGGATTGGGGATCTATATTG
GAAGGCATCTGACAACTTCTACCAGCACCTTTTGATGAATAATTTGAATCCAGCTTTGTGCGTATAGTGGGGATTTCTATCTGAGCTTGT
GACACAGCTAACTCAGGAGCTGTTATGGTCCTTGGGTGGCTGTTTCACTTGTTTTTATTTGTTCTGTAAATACTGCTTTCCTAATTTAGT
AAAATGAAAGAATAGACACTAAAATCACACTGACCTATACTTATACCTATAGAATCAGTTAATAAGGGTATCAGACTGATTAATATCTAC
TGTAACAATTTGGCAGTGAGTTTTCTTTGGATATTAGTATAAATATGTAAGTATCGTTTTAATATATTAGTCATGATATAGCATTTTAAA
AATTATCTGTAACCTGAATTCTGTTAAAACACTTTATATTCCAAAAGAATGAATGACAGTGATATTAAAATCACTACATTAAAGGGTTTG

>5422_5422_10_API5-GANC_API5_chr11_43343686_ENST00000534600_GANC_chr15_42598744_ENST00000566442_length(amino acids)=358AA_BP=187
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKENQEDLGLWEEKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAESHQLKNTGDGDAYRLYNLDVYGYQIYDKMGIYGSVP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for API5-GANC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for API5-GANC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGANCQ8TET4DB00491MiglitolAntagonistSmall moleculeApproved

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Related Diseases for API5-GANC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource