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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:API5-LCMT1 (FusionGDB2 ID:HG8539TG51451)

Fusion Gene Summary for API5-LCMT1

check button Fusion gene summary
Fusion gene informationFusion gene name: API5-LCMT1
Fusion gene ID: hg8539tg51451
HgeneTgene
Gene symbol

API5

LCMT1

Gene ID

8539

51451

Gene nameapoptosis inhibitor 5leucine carboxyl methyltransferase 1
SynonymsAAC-11|AAC11CGI-68|LCMT|PPMT1
Cytomap('API5')('LCMT1')

11p12

16p12.1

Type of geneprotein-codingprotein-coding
Descriptionapoptosis inhibitor 5FIFantiapoptosis clone 11 proteincell migration-inducing gene 8 proteinfibroblast growth factor 2-interacting factor 2migration-inducing protein MIG8leucine carboxyl methyltransferase 1[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1protein phosphatase methyltransferase 1protein-leucine O-methyltransferase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000529334, ENST00000378852, 
ENST00000420461, ENST00000455725, 
ENST00000531273, ENST00000534600, 
ENST00000534695, 
Fusion gene scores* DoF score7 X 5 X 5=1755 X 7 X 4=140
# samples 76
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/140*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: API5 [Title/Abstract] AND LCMT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPI5(43357544)-LCMT1(25172422), # samples:2
Anticipated loss of major functional domain due to fusion event.API5-LCMT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
API5-LCMT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
API5-LCMT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
API5-LCMT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
API5-LCMT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
API5-LCMT1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
API5-LCMT1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLCMT1

GO:0006481

C-terminal protein methylation

10600115


check buttonFusion gene breakpoints across API5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LCMT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OQAPI5chr11

43357544

+LCMT1chr16

25172422

+


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Fusion Gene ORF analysis for API5-LCMT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000529334ENST00000399069API5chr11

43357544

+LCMT1chr16

25172422

+
3UTR-3UTRENST00000529334ENST00000572869API5chr11

43357544

+LCMT1chr16

25172422

+
3UTR-intronENST00000529334ENST00000380966API5chr11

43357544

+LCMT1chr16

25172422

+
5CDS-3UTRENST00000378852ENST00000572869API5chr11

43357544

+LCMT1chr16

25172422

+
5CDS-3UTRENST00000420461ENST00000572869API5chr11

43357544

+LCMT1chr16

25172422

+
5CDS-3UTRENST00000455725ENST00000572869API5chr11

43357544

+LCMT1chr16

25172422

+
5CDS-3UTRENST00000531273ENST00000572869API5chr11

43357544

+LCMT1chr16

25172422

+
5CDS-3UTRENST00000534600ENST00000572869API5chr11

43357544

+LCMT1chr16

25172422

+
5CDS-intronENST00000378852ENST00000380966API5chr11

43357544

+LCMT1chr16

25172422

+
5CDS-intronENST00000420461ENST00000380966API5chr11

43357544

+LCMT1chr16

25172422

+
5CDS-intronENST00000455725ENST00000380966API5chr11

43357544

+LCMT1chr16

25172422

+
5CDS-intronENST00000531273ENST00000380966API5chr11

43357544

+LCMT1chr16

25172422

+
5CDS-intronENST00000534600ENST00000380966API5chr11

43357544

+LCMT1chr16

25172422

+
Frame-shiftENST00000534600ENST00000399069API5chr11

43357544

+LCMT1chr16

25172422

+
In-frameENST00000378852ENST00000399069API5chr11

43357544

+LCMT1chr16

25172422

+
In-frameENST00000420461ENST00000399069API5chr11

43357544

+LCMT1chr16

25172422

+
In-frameENST00000455725ENST00000399069API5chr11

43357544

+LCMT1chr16

25172422

+
In-frameENST00000531273ENST00000399069API5chr11

43357544

+LCMT1chr16

25172422

+
intron-3CDSENST00000534695ENST00000399069API5chr11

43357544

+LCMT1chr16

25172422

+
intron-3UTRENST00000534695ENST00000572869API5chr11

43357544

+LCMT1chr16

25172422

+
intron-intronENST00000534695ENST00000380966API5chr11

43357544

+LCMT1chr16

25172422

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000455725API5chr1143357544+ENST00000399069LCMT1chr1625172422+245117042452242665
ENST00000531273API5chr1143357544+ENST00000399069LCMT1chr1625172422+237816311212169682
ENST00000420461API5chr1143357544+ENST00000399069LCMT1chr1625172422+220714601121998628
ENST00000378852API5chr1143357544+ENST00000399069LCMT1chr1625172422+236416171072155682

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000455725ENST00000399069API5chr1143357544+LCMT1chr1625172422+0.003837810.9961622
ENST00000531273ENST00000399069API5chr1143357544+LCMT1chr1625172422+0.0020482790.9979518
ENST00000420461ENST00000399069API5chr1143357544+LCMT1chr1625172422+0.0020470890.99795294
ENST00000378852ENST00000399069API5chr1143357544+LCMT1chr1625172422+0.0020782860.99792176

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Fusion Genomic Features for API5-LCMT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
API5chr1143357544+LCMT1chr1625172422+0.0004413250.9995586
API5chr1143357544+LCMT1chr1625172422+0.0004413250.9995586

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for API5-LCMT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:43357544/chr16:25172422)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPI5chr11:43357544chr16:25172422ENST00000378852+1314454_475497505.0MotifNuclear localization signal
HgeneAPI5chr11:43357544chr16:25172422ENST00000531273+1314454_475497525.0MotifNuclear localization signal
HgeneAPI5chr11:43357544chr16:25172422ENST00000378852+13142_360497505.0RegionNote=ARM-like and Heat-like helical repeats
HgeneAPI5chr11:43357544chr16:25172422ENST00000378852+1314370_391497505.0RegionNote=Leucine-zipper
HgeneAPI5chr11:43357544chr16:25172422ENST00000420461+12132_360443451.0RegionNote=ARM-like and Heat-like helical repeats
HgeneAPI5chr11:43357544chr16:25172422ENST00000420461+1213370_391443451.0RegionNote=Leucine-zipper
HgeneAPI5chr11:43357544chr16:25172422ENST00000531273+13142_360497525.0RegionNote=ARM-like and Heat-like helical repeats
HgeneAPI5chr11:43357544chr16:25172422ENST00000531273+1314370_391497525.0RegionNote=Leucine-zipper
TgeneLCMT1chr11:43357544chr16:25172422ENST0000038096609171_1720280.0RegionS-adenosyl-L-methionine binding
TgeneLCMT1chr11:43357544chr16:25172422ENST00000399069411171_172155335.0RegionS-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPI5chr11:43357544chr16:25172422ENST00000420461+1213454_475443451.0MotifNuclear localization signal


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Fusion Gene Sequence for API5-LCMT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5423_5423_1_API5-LCMT1_API5_chr11_43357544_ENST00000378852_LCMT1_chr16_25172422_ENST00000399069_length(transcript)=2364nt_BP=1617nt
GCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCGCCGGTCAGGACAAG
GATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGCCACGG
AGCAAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTA
TTCCGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTC
GACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAG
ATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCC
AAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAA
AGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATTTGTTCTATTTATGAAGATACTGT
CTGGGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGCCGACCTAGAACAGACCTTCAATC
CCTCGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAAAAATGTCCATTCCACAAGGTTTG
TGACATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGATATACAGTTGGAGGTATTGAAAT
TGTTGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATTTGATAAGTTATTGGAATACATGC
CCCTCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAGTTATGTGGAATGTTTGTTGTACA
GTTTTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAAAGATTTCAAAATCAGGCTGCAGT
ACTTTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGAGGCCTTAAAAACAGAAGAGAACA
AGATTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACATTCCTCCTTCTTATAAGAGCACAG
TAACACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACAACTTCAGGTTCACCACCCAAGAAAT
CTTCAGCAGGACCAAAAAGAGATGCCAGGCAGATTTATAACCCTCCCAGTGGGAAATATAGCAGCAATTTGGGCAACTTTAATTATGATG
GACACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCAGATCTCCGAGACCTGTCTGAACTGGAAGAGAAGCTAAAGAAATGTAACA
TGAATACACAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAG
CCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGA
GACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCAT
CGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGC
TGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAGATAACTTATTAATCTG
TCGAAGGCTTATGCCGAGCCAGAAGCCGAAGCCACTTGCCCTCCTGGAGGAGACCTGCAAGCTCCCTGAGCGGTGGGCGGGCCTCGTCCG
CAGGTCTCATCCCACACTCTTGAGAAGCCTTGGTCACTACAGTGGTCGCACATGTTCCTCTTCCTGTTCCTGTTGACATGTCGTTGTTTA

>5423_5423_1_API5-LCMT1_API5_chr11_43357544_ENST00000378852_LCMT1_chr16_25172422_ENST00000399069_length(amino acids)=682AA_BP=503
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCE
QVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLG
RKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWK
PVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLP
TLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMM

--------------------------------------------------------------
>5423_5423_2_API5-LCMT1_API5_chr11_43357544_ENST00000420461_LCMT1_chr16_25172422_ENST00000399069_length(transcript)=2207nt_BP=1460nt
GACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCGCCGGTCAGG
ACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGC
CACGGAGCAAGTGGGCCAGATTCGACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATAT
ACTAACGCAACTTTTGCAGACAGATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGG
GACTTTAGGTGGGTTGTTCAGCCAAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGAC
TTTACCAGATGAAGTCTTAACAAAGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATT
TGTTCTATTTATGAAGATACTGTCTGGGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGC
CGACCTAGAACAGACCTTCAATCCCTCGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAA
AAATGTCCATTCCACAAGGTTTGTGACATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGA
TATACAGTTGGAGGTATTGAAATTGTTGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATT
TGATAAGTTATTGGAATACATGCCCCTCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAG
TTATGTGGAATGTTTGTTGTACAGTTTTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAA
AGATTTCAAAATCAGGCTGCAGTACTTTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGA
GGCCTTAAAAACAGAAGAGAACAAGATTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACAT
TCCTCCTTCTTATAAGAGCACAGTAACACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACAAC
TTCAGGTTCACCACCCAAGAAATCTTCAGCAGGACCAAAAAGAGATGCCAGGCAGATTTATAACCCTCCCAGTGGGAAATATAGCAGCAA
TTTGGGCAACTTTAATTATGATGGACACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCAGATCTCCGAGACCTGTCTGAACTGGA
AGAGAAGCTAAAGAAATGTAACATGAATACACAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTC
CGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCA
GATCATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCT
GTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACT
TGAATTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCT
GAAGGAGATAACTTATTAATCTGTCGAAGGCTTATGCCGAGCCAGAAGCCGAAGCCACTTGCCCTCCTGGAGGAGACCTGCAAGCTCCCT
GAGCGGTGGGCGGGCCTCGTCCGCAGGTCTCATCCCACACTCTTGAGAAGCCTTGGTCACTACAGTGGTCGCACATGTTCCTCTTCCTGT

>5423_5423_2_API5-LCMT1_API5_chr11_43357544_ENST00000420461_LCMT1_chr16_25172422_ENST00000399069_length(amino acids)=628AA_BP=449
MGLSLTMPTVEELYRNYGILADATEQVGQIRRQAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFS
QILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFN
PSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYM
PLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEEN
KIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYD
GHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLPTLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLR

--------------------------------------------------------------
>5423_5423_3_API5-LCMT1_API5_chr11_43357544_ENST00000455725_LCMT1_chr16_25172422_ENST00000399069_length(transcript)=2451nt_BP=1704nt
GCAGCCGCGCTGTGCGCGGTGACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGG
CGGCGGTGGCGCCGGTCAGGACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAAT
TATGGCATCCTGGCCGATGCCACGGAGCAAGTGGGCCAGACTCATCCATCTCCCCCAACTCAAAAATGAAACAAAGATGGAGGGAGAACG
GAATTGGGAAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTATTC
CGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTCGAC
GTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAGATG
ACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCCAAA
TACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAAAGG
AAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATTTGTTCTATTTATGAAGATACTGTCTG
GGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGCCGACCTAGAACAGACCTTCAATCCCT
CGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAAAAATGTCCATTCCACAAGGTTTGTGA
CATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGATATACAGTTGGAGGTATTGAAATTGT
TGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATTTGATAAGTTATTGGAATACATGCCCC
TCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAGTTATGTGGAATGTTTGTTGTACAGTT
TTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAAAGATTTCAAAATCAGGCTGCAGTACT
TTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGAGGCCTTAAAAACAGAAGAGAACAAGA
TTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACATTCCTCCTTCTTATAAGAGCACAGTAA
CACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACAACTTCAGGTTCACCACCCAAGAAATCTT
CAGCAGGACCAAAAAGAGATGCCAGGCAGATTTATAACCCTCCCAGTGGGAAATATAGCAGCAATTTGGGCAACTTTAATTATGATGGAC
ACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCAGATCTCCGAGACCTGTCTGAACTGGAAGAGAAGCTAAAGAAATGTAACATGA
ATACACAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCA
ACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGAGAC
GCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCGG
CCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGCTGC
TGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAGATAACTTATTAATCTGTCG
AAGGCTTATGCCGAGCCAGAAGCCGAAGCCACTTGCCCTCCTGGAGGAGACCTGCAAGCTCCCTGAGCGGTGGGCGGGCCTCGTCCGCAG
GTCTCATCCCACACTCTTGAGAAGCCTTGGTCACTACAGTGGTCGCACATGTTCCTCTTCCTGTTCCTGTTGACATGTCGTTGTTTAAAT

>5423_5423_3_API5-LCMT1_API5_chr11_43357544_ENST00000455725_LCMT1_chr16_25172422_ENST00000399069_length(amino acids)=665AA_BP=486
MKQRWRENGIGKHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADI
LTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEF
VLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLGTLTTPVEGLD
IQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLK
DFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRASEDTT
SGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLPTLLIAECVLVYMTPEQS
ANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMMELYNRLPRAEVSRIESL

--------------------------------------------------------------
>5423_5423_4_API5-LCMT1_API5_chr11_43357544_ENST00000531273_LCMT1_chr16_25172422_ENST00000399069_length(transcript)=2378nt_BP=1631nt
GTGCGCGGTGACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCG
CCGGTCAGGACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCT
GGCCGATGCCACGGAGCAAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATT
AGCAGCTCAATTTATTCCGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGA
AGATGTATCTATTCGACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCA
ACTTTTGCAGACAGATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGG
TGGGTTGTTCAGCCAAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGA
TGAAGTCTTAACAAAGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATTTGTTCTATT
TATGAAGATACTGTCTGGGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGCCGACCTAGA
ACAGACCTTCAATCCCTCGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAAAAATGTCCA
TTCCACAAGGTTTGTGACATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGATATACAGTT
GGAGGTATTGAAATTGTTGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATTTGATAAGTT
ATTGGAATACATGCCCCTCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAGTTATGTGGA
ATGTTTGTTGTACAGTTTTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAAAGATTTCAA
AATCAGGCTGCAGTACTTTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGAGGCCTTAAA
AACAGAAGAGAACAAGATTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACATTCCTCCTTC
TTATAAGAGCACAGTAACACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACAACTTCAGGTTC
ACCACCCAAGAAATCTTCAGCAGGACCAAAAAGAGATGCCAGGCAGATTTATAACCCTCCCAGTGGGAAATATAGCAGCAATTTGGGCAA
CTTTAATTATGATGGACACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCAGATCTCCGAGACCTGTCTGAACTGGAAGAGAAGCT
AAAGAAATGTAACATGAATACACAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCT
CCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGAT
TGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGG
GTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCT
GGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAGAT
AACTTATTAATCTGTCGAAGGCTTATGCCGAGCCAGAAGCCGAAGCCACTTGCCCTCCTGGAGGAGACCTGCAAGCTCCCTGAGCGGTGG
GCGGGCCTCGTCCGCAGGTCTCATCCCACACTCTTGAGAAGCCTTGGTCACTACAGTGGTCGCACATGTTCCTCTTCCTGTTCCTGTTGA

>5423_5423_4_API5-LCMT1_API5_chr11_43357544_ENST00000531273_LCMT1_chr16_25172422_ENST00000399069_length(amino acids)=682AA_BP=503
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCE
QVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLG
RKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWK
PVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLP
TLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMM

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Fusion Gene PPI Analysis for API5-LCMT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for API5-LCMT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for API5-LCMT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0012684Blastocyst Disintegration1CTD_human
TgeneC0013937Embryo Resorption1CTD_human
TgeneC0752350Embryo Death1CTD_human
TgeneC0752351Embryo Loss1CTD_human
TgeneC1136082Embryo Disintegration1CTD_human