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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AGPS-PHOCN (FusionGDB2 ID:HG8540TG25843)

Fusion Gene Summary for AGPS-PHOCN

check button Fusion gene summary
Fusion gene informationFusion gene name: AGPS-PHOCN
Fusion gene ID: hg8540tg25843
HgeneTgene
Gene symbol

AGPS

PHOCN

Gene ID

8540

25843

Gene namealkylglycerone phosphate synthaseMOB family member 4, phocein
SynonymsADAP-S|ADAS|ADHAPS|ADPS|ALDHPSY|RCDP32C4D|CGI-95|MOB1|MOB3|MOBKL3|PHOCN|PREI3
Cytomap('AGPS','AGPS')('MOB4','PHOCN')

2q31.2

2q33.1

Type of geneprotein-codingprotein-coding
Descriptionalkyldihydroxyacetonephosphate synthase, peroxisomalaging-associated gene 5 proteinaging-associated protein 5alkyl-DHAP synthaseMOB-like protein phoceinMOB1, Mps One Binder kinase activator-like 3Mps One Binder kinase activator-like 3class II mMOB1mob1 homolog 3phocein, Mob-like proteinpreimplantation protein 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264167, ENST00000409888, 
Fusion gene scores* DoF score8 X 8 X 7=4482 X 2 X 2=8
# samples 102
** MAII scorelog2(10/448*10)=-2.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: AGPS [Title/Abstract] AND PHOCN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAGPS(178378636)-MOB4(198404835), # samples:2
AGPS(178378636)-PHOCN(198404835), # samples:1
Anticipated loss of major functional domain due to fusion event.AGPS-MOB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGPS-MOB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGPS-MOB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AGPS-MOB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAGPS

GO:0008610

lipid biosynthetic process

9553082


check buttonFusion gene breakpoints across AGPS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PHOCN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-DQ-7594-01AAGPSchr2

178378636

+MOB4chr2

198404835

+
ChimerDB4HNSCTCGA-DQ-7594AGPSchr2

178378636

+MOB4chr2

198404835

+
ChimerDB4HNSCTCGA-DQ-7594-01AAGPSchr2

178378636

-PHOCNchr2

198404835

+


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Fusion Gene ORF analysis for AGPS-PHOCN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000264167ENST00000409360AGPSchr2

178378636

+MOB4chr2

198404835

+
5CDS-3UTRENST00000264167ENST00000497443AGPSchr2

178378636

+MOB4chr2

198404835

+
5CDS-5UTRENST00000264167ENST00000323303AGPSchr2

178378636

+MOB4chr2

198404835

+
5CDS-5UTRENST00000264167ENST00000409916AGPSchr2

178378636

+MOB4chr2

198404835

+
5CDS-5UTRENST00000264167ENST00000448447AGPSchr2

178378636

+MOB4chr2

198404835

+
In-frameENST00000264167ENST00000233892AGPSchr2

178378636

+MOB4chr2

198404835

+
intron-3CDSENST00000409888ENST00000233892AGPSchr2

178378636

+MOB4chr2

198404835

+
intron-3UTRENST00000409888ENST00000409360AGPSchr2

178378636

+MOB4chr2

198404835

+
intron-3UTRENST00000409888ENST00000497443AGPSchr2

178378636

+MOB4chr2

198404835

+
intron-5UTRENST00000409888ENST00000323303AGPSchr2

178378636

+MOB4chr2

198404835

+
intron-5UTRENST00000409888ENST00000409916AGPSchr2

178378636

+MOB4chr2

198404835

+
intron-5UTRENST00000409888ENST00000448447AGPSchr2

178378636

+MOB4chr2

198404835

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264167AGPSchr2178378636+ENST00000233892MOB4chr2198404835+53501843682296742

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264167ENST00000233892AGPSchr2178378636+MOB4chr2198404835+0.0001290850.9998709

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Fusion Genomic Features for AGPS-PHOCN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AGPSchr2178378636+MOB4chr2198404834+3.53E-070.99999964
AGPSchr2178378636+MOB4chr2198404834+3.53E-070.99999964
AGPSchr2178378636+MOB4chr2198404834+3.53E-070.99999964
AGPSchr2178378636+MOB4chr2198404834+3.53E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AGPS-PHOCN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:178378636/:198404835)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGPSchr2:178378636chr2:198404835ENST00000264167+17202_8565659.0Compositional biasNote=Poly-Ala
HgeneAGPSchr2:178378636chr2:198404835ENST00000264167+1720202_384565659.0DomainFAD-binding PCMH-type
HgeneAGPSchr2:178378636chr2:198404835ENST00000264167+1720234_240565659.0Nucleotide bindingFAD
HgeneAGPSchr2:178378636chr2:198404835ENST00000264167+1720303_309565659.0Nucleotide bindingFAD
HgeneAGPSchr2:178378636chr2:198404835ENST00000264167+1720316_319565659.0Nucleotide bindingFAD
HgeneAGPSchr2:178378636chr2:198404835ENST00000264167+1720368_374565659.0Nucleotide bindingFAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGPSchr2:178378636chr2:198404835ENST00000264167+1720615_617565659.0RegionImportant for enzyme activity
HgeneAGPSchr2:178378636chr2:198404835ENST00000264167+1720654_658565659.0RegionImportant for enzyme activity


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Fusion Gene Sequence for AGPS-PHOCN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2981_2981_1_AGPS-MOB4_AGPS_chr2_178378636_ENST00000264167_MOB4_chr2_198404835_ENST00000233892_length(transcript)=5350nt_BP=1843nt
GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC
TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG
GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT
CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA
CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA
AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA
TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAGCATCCTTAAATCCTAGTGATACACCTCCTTCTGTTGTAAATG
AAGATTTTCTTCATGACCTTAAAGAAACTAATATTTCATATTCACAAGAGGCAGATGATCGAGTATTTAGAGCTCATGGTCATTGTCTTC
ATGAGATATTTTTGCTCAGGGAAGGAATGTTTGAGCGAATTCCTGATATAGTTTTATGGCCAACATGCCATGATGATGTAGTTAAGATTG
TGAATCTAGCTTGCAAATATAATCTTTGTATCATACCAATTGGTGGAGGAACAAGTGTTTCATATGGCCTGATGTGTCCTGCAGATGAGA
CAAGAACAATTATTTCTTTGGACACTTCACAAATGAATCGAATTCTCTGGGTTGATGAGAACAATTTGACAGCTCATGTAGAGGCTGGCA
TAACAGGACAAGAGTTGGAAAGACAGCTTAAAGAAAGTGGTTATTGTACAGGTCATGAACCAGATTCCCTGGAGTTCAGTACTGTAGGAG
GATGGGTATCTACTCGCGCATCAGGCATGAAGAAGAATATCTATGGCAATATCGAGGACCTGGTGGTTCATATAAAAATGGTAACACCTA
GAGGTATAATAGAAAAAAGCTGTCAAGGACCTCGTATGTCAACAGGCCCTGATATCCATCACTTCATCATGGGATCTGAAGGAACTCTTG
GTGTAATAACAGAAGCTACAATAAAAATCAGACCAGTCCCTGAATACCAAAAGTATGGCTCAGTAGCTTTCCCTAATTTTGAACAAGGAG
TAGCCTGTTTAAGAGAAATTGCAAAACAGAGATGTGCTCCGGCATCTATTCGCCTCATGGACAACAAGCAGTTTCAGTTTGGTCATGCTC
TTAAACCTCAGGTTTCCTCTATTTTTACATCATTTTTGGACGGATTAAAAAAGTTTTATATTACAAAGTTTAAAGGATTTGACCCAAATC
AGCTAAGTGTAGCCACATTACTGTTTGAGGGGGATCGTGAGAAGGTTCTTCAACATGAAAAACAAGTGTATGATATTGCTGCAAAATTTG
GTGGGTTGGCAGCTGGAGAAGATAATGGACAGAGAGGTTATTTGCTGACCTATGTTATTGCATACATTCGAGACTTGGCTTTGGAATACT
ATGTATTAGGAGAATCTTTTGAGACTTCTGCTCCTTGGGACAGGGTGGTAGATCTCTGTAGAAATGTAAAAGAAAGAATAACAAGGGAAT
GCAAAGAGAAGGGTGTTCAGTTTGCTCCTTTTTCTACATGCAGGCAGTTCTGCCTTGAGCTAAATGGACTTGCTGTCAAACTTCAGAGTG
AATGCCATCCAGATACTTGCACTCAAATGACAGCAACTGAACAATGGATTTTTCTTTGTGCAGCTCATAAAACTCCAAAAGAGTGTCCTG
CTATAGACTATACTAGACACACACTTGATGGTGCTGCATGTCTTCTGAATAGCAATAAATATTTTCCCAGCAGGGTTAGCATAAAGGAAT
CATCTGTAGCGAAACTAGGATCAGTATGCCGTAGGATTTACAGAATATTTTCACATGCTTATTTTCATCATCGGCAGATATTTGATGAAT
ATGAAAATGAAACATTTTTGTGTCATCGGTTTACTAAGTTTGTGATGAAATACAATTTGATGTCCAAGGATAACCTGATTGTACCAATTT
TAGAAGAGGAAGTACAGAATTCAGTTTCTGGGGAAAGTGAAGCATGAAGGGAATCATAGGAAAAATGTACTGATCATATAATTAACATTA
TGTACTGTATATATCATTTTAGACACATCAATCATGTATCCATATTATAGCTTCTTTGTTTAGTATAGGTTTTTGTATGCTGGGTTTGCC
TTTTAAAATGGGAAATACTTTTTAAGTTATTCATAAGCTGTATATTCACCAGTGTGGCACTCATGGTTTTTAAATAAGATTAGTATTATC
TGTTTATAATGCCTGTTAATAAAAGAATTTACAGTTTGGTAAAATTGCTGCTAAACAATCATTGGATCACAATCCTCATCAGACAAACCC
ATCTGTAAAAAAAATGAGGGAGAGCTTGAGGTTTCACACAAGCCATTTACTAAAGAGGTAGAAATGTTTTCTATTGGTTTTACCTTGAGT
TTAGATATCCTAAAAAATTCTGTAGTACGTAGTTTTGTCTTACCTGTTAACTTTCCCCAATTGAGATAAAAGTGTTTTAAAATTCTGTTT
ATAGTTTTTGATATGCATATATAATTATGTGTATATCTAAATACAAATGCAAATGAAGCATTAGTAATACTTAAATAATTTTACTGTGCT
ACATAAAGTATAACATACTTGGAAAGGATTTACCGTTCTGCAACAACGGACTGGTACATACAGGATGATCACAATGGTAAGGCACATAAA
TTATTTTCCCACTGGAAACCTGCCCTGTCCACCCCTTCTCATTTCCCTTAACCTTATCTTCAAACTACTTTAGCTGAGAAGCTTTTCACC
AGACTGAGTTAGTGGTGGCTTATACCTATTTATATTTGTATTAATTGCTTACAGATTATACCTCATATTAGCAATTACATTACACTACAA
GAAAATGTATTTGCATAGGCTCTTGCTTATCTTTGTTTTGCAAAATTGTTCTACTTAGAAAACAGTCCTTAAAATAGTTTGACTCTTCCT
GTTAGTAATATATTAATCTTTCATTTAACCAGCTAGGCAGCATTAAATAGAATTGAAGAAATACCATAGTATTTATTTTACACCCCCTCT
CCCACGAAGTTTATGTTTGGATTACATGCACGTGTGAGATTATTTGCAATAATTCATAGGTTCCAAGGGTGTTGATGAATAGTCATACAT
TTTTTTGGACTTTGTTATAATTCATTGTGGTAAGAATGATTGAAATGCAGATTTAACAATCTTATAATCTATTGAATGCCATTTTTGATA
AAGCACTGGAGGTCTTATTGCCAAACTGATTGTAATGAGGCAGTAAGGGTGAAAACATTGTACATGTTGTGAAGAAAGTATTTAAATCCA
ACTTTTGAACAGATTTAACAAACATGAGGAACTTTTTTATTTAGAAGGATAATTTTGAAGATGAAAATGTATTCATCTTAATTGTTTTTT
CAAATTTAAGGGAATAATTTATACCATCTTTTCAGACAAGAATGTACAGCAAAAATAAGGGGAACAGTAGTATACTGAGAGTGTGTGTAT
GTATAGTGTATGCCTTTCCAAGCTTGCCAGTCTTTTTGGCTTTGAACACTGCCCATCAGCTACAGTCATTACTGTTCCCCAACCCACAAC
TATCTTTTAAGAAGTCTTAGTTCACAGTGAAAGGAATGATGACTTTGAAATTATGGATTTATATTAATGGCACTATAAACCAATGGTAAT
GGTAATTTTTAAACTTGCTAAATATTGAGAAACTAAACTACTAAGTTAATAAATTATATATAGCAGTGTAGCTGTTCTCTCTAGATGGTG
TCTCACAATGGATTTCTGTTGCTTGACTATTTTCTTAGTGAATATTTATACTAAGGTAGTGACTGAGATTTGGTGATCTGGCTGAGTATT
TTGAAACACATTTTGAATAATATGGCTTAGTGTTAACGGGGACTTAAATATGATTTTTTTTTCTTACTCATTTCACCTTCCCTGTACTGT
ATGTTTGGAATTGATCATAAAACATCTCCAAAAGAAAATAATCAGTTTGTAGTCTTGCTTTTGTATTCATGTTGATAATCTTACTAATTG
TGAAGTTGATTCACTACTATACTAGGTAAGACCTAAGTGAAACAGTTCCTGTTTTTCCTTAATACTGTTTTCAGAATTTTGAAAATGTAC
TTATATATACATAAATACTACTAAAAAATTAATGAGCCTGGCAAACCATTGATTTATAAAAGTAAGTGTTCTAAGAGGGGAACAAGACAG
TTCTGTGTGATAAGGAAGTTAGGCTCCACTTTTTGTTTGAATTACCCTATGTATATCCGAAGGTAAACTTAGGCTTTTCTTTCCAAAAGA
TCGTATAGTCAATTCATTCTTTTTCTCCTATCACATCTGGGAAAGTAGCTAACTTTTAACTATTTATGTTCCCATAAGTAACCCTTCTTT
TGTGTGTATACATTTCCTTTTCTCTGACTTGAGATGTCAAATTTGGATTTCTAGAACAGTTTCTCAGTTAAATTCTTGATGACTTAACAA
CTTTTACTATCAGAATACAATTAGAAATCCTTGGTCAGGCACAGGGGCTCACGCCTGTAATCCCAGCACTTTGGGAAGCCAAGGCAGACA
GATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGT
GCTACTCGTGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGTGGAGGTTGCGGTGAGCTGAGATCGTGCCATTGCACTCCAGCCTG
GGTAACGAGCAAAACTCCGTCTCAAAAACTCCGTCTCAAAAAAAAAAAATCCTTGATTACATTGTTAGTAAGGACTGTGTTACGATTATA
AACACATTTATTGGTTGATGTCAAATTCACTGTAATAGTAGAACTAAGTTTTTTATGTGAGTACTTTGCCCTACTGTCTATATGATGACA
TCTTTTTTGAGCAGCTAAATTTTAAATTGTATATACTTTATTTTGTGAATCCTTGTTGAATGTGCTAAAGGTTTCTTTGTGTAGTTCTTC
CATGCTATGCGAATATTTTAGTAAAAGTAGTTGATTTTTA

>2981_2981_1_AGPS-MOB4_AGPS_chr2_178378636_ENST00000264167_MOB4_chr2_198404835_ENST00000233892_length(amino acids)=742AA_BP=591
MVAPGAALSDLSPAPSGSGRQHKAVAMAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAA
SAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSD
TPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYG
LMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQLKESGYCTGHEPDSLEFSTVGGWVSTRASGMKKNIYGNIEDLVV
HIKMVTPRGIIEKSCQGPRMSTGPDIHHFIMGSEGTLGVITEATIKIRPVPEYQKYGSVAFPNFEQGVACLREIAKQRCAPASIRLMDNK
QFQFGHALKPQVSSIFTSFLDGLKKFYITKFKGFDPNQLSVATLLFEGDREKVLQHEKQVYDIAAKFGGLAAGEDNGQRGYLLTYVIAYI
RDLALEYYVLGESFETSAPWDRVVDLCRNVKERITRECKEKGVQFAPFSTCRQFCLELNGLAVKLQSECHPDTCTQMTATEQWIFLCAAH
KTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYENETFLCHRFTKFVMKYNLMSK
DNLIVPILEEEVQNSVSGESEA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AGPS-PHOCN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AGPS-PHOCN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AGPS-PHOCN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGPSC0282529Chondrodysplasia Punctata, Rhizomelic11CLINGEN
HgeneAGPSC1838612Rhizomelic chondrodysplasia punctata, type 35CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT