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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DISP2-CREBBP (FusionGDB2 ID:HG85455TG1387)

Fusion Gene Summary for DISP2-CREBBP

check button Fusion gene summary
Fusion gene informationFusion gene name: DISP2-CREBBP
Fusion gene ID: hg85455tg1387
HgeneTgene
Gene symbol

DISP2

CREBBP

Gene ID

85455

1387

Gene namedispatched RND transporter family member 2CREB binding protein
SynonymsC15orf36|DISPB|HsT16908|LINC00594CBP|KAT3A|MKHK1|RSTS|RSTS1
Cytomap('DISP2')('CREBBP')

15q15.1

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein dispatched homolog 2dispatched Blong intergenic non-protein coding RNA 594CREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBP
Modification date2020031320200329
UniProtAcc.

Q92793

Ensembl transtripts involved in fusion geneENST00000267889, 
Fusion gene scores* DoF score4 X 4 X 3=4818 X 30 X 8=4320
# samples 428
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/4320*10)=-3.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DISP2 [Title/Abstract] AND CREBBP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDISP2(40657926)-CREBBP(3860780), # samples:1
Anticipated loss of major functional domain due to fusion event.DISP2-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DISP2-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DISP2-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DISP2-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCREBBP

GO:0000122

negative regulation of transcription by RNA polymerase II

21539536

TgeneCREBBP

GO:0006355

regulation of transcription, DNA-templated

12169688

TgeneCREBBP

GO:0006473

protein acetylation

15273251|24207024|24939902|28790157|30540930

TgeneCREBBP

GO:0016573

histone acetylation

11742995

TgeneCREBBP

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

TgeneCREBBP

GO:0034644

cellular response to UV

24939902

TgeneCREBBP

GO:0045893

positive regulation of transcription, DNA-templated

11742995

TgeneCREBBP

GO:1990258

histone glutamine methylation

30540930


check buttonFusion gene breakpoints across DISP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CREBBP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4H5DISP2chr15

40657926

+CREBBPchr16

3860780

-


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Fusion Gene ORF analysis for DISP2-CREBBP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000267889ENST00000262367DISP2chr15

40657926

+CREBBPchr16

3860780

-
In-frameENST00000267889ENST00000382070DISP2chr15

40657926

+CREBBPchr16

3860780

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000267889DISP2chr1540657926+ENST00000262367CREBBPchr163860780-1022710328775622491
ENST00000267889DISP2chr1540657926+ENST00000382070CREBBPchr163860780-762810328774482453

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000267889ENST00000262367DISP2chr1540657926+CREBBPchr163860780-0.0029797930.9970202
ENST00000267889ENST00000382070DISP2chr1540657926+CREBBPchr163860780-0.0101855970.9898144

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Fusion Genomic Features for DISP2-CREBBP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DISP2-CREBBP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:40657926/chr16:3860780)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CREBBP

Q92793

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78170_1903151402.0TransmembraneHelical
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311061_10642662443.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311199_14872662443.0Compositional biasNote=Cys/His-rich
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311555_15622662443.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311943_19482662443.0Compositional biasNote=Poly-Pro
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311967_19702662443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671312081_20852662443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671312199_22162662443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671312245_22482662443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671312297_23002662443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301061_10642662405.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301199_14872662405.0Compositional biasNote=Cys/His-rich
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301555_15622662405.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301943_19482662405.0Compositional biasNote=Poly-Pro
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301967_19702662405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701302081_20852662405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701302199_22162662405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701302245_22482662405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701302297_23002662405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311103_11752662443.0DomainBromo
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311323_17002662443.0DomainCBP/p300-type HAT
TgeneCREBBPchr15:40657926chr16:3860780ENST00000262367131587_6662662443.0DomainKIX
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301103_11752662405.0DomainBromo
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301323_17002662405.0DomainCBP/p300-type HAT
TgeneCREBBPchr15:40657926chr16:3860780ENST00000382070130587_6662662405.0DomainKIX
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311434_14362662443.0RegionAcetyl-CoA binding
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311446_14472662443.0RegionAcetyl-CoA binding
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301434_14362662405.0RegionAcetyl-CoA binding
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301446_14472662405.0RegionAcetyl-CoA binding
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311701_17442662443.0Zinc fingerZZ-type
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311765_18462662443.0Zinc fingerTAZ-type 2
TgeneCREBBPchr15:40657926chr16:3860780ENST00000262367131347_4332662443.0Zinc fingerTAZ-type 1
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301701_17442662405.0Zinc fingerZZ-type
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301765_18462662405.0Zinc fingerTAZ-type 2
TgeneCREBBPchr15:40657926chr16:3860780ENST00000382070130347_4332662405.0Zinc fingerTAZ-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78471_6433151402.0DomainSSD
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+781019_10393151402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+781064_10843151402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+781088_11083151402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78484_5043151402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78510_5303151402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78542_5623151402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78589_6093151402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78617_6373151402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78704_7243151402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78964_9843151402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78990_10103151402.0TransmembraneHelical


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Fusion Gene Sequence for DISP2-CREBBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22945_22945_1_DISP2-CREBBP_DISP2_chr15_40657926_ENST00000267889_CREBBP_chr16_3860780_ENST00000262367_length(transcript)=10227nt_BP=1032nt
CGCCGCCGCTGCCGCCGCCACCGCCGCCGCCGCCGCCGCCGCCGCGGCTTCAGCACCAGCGCCCGGACAGCGGTGCCGCCCACGGGCATG
GACGGTGACAGCAGCAGCAGCAGCGGCGGCAGCGGTCCGGCTCCCGGCCCGGGTCCGGAAGGGGAGCAACGGCCCGAGGGGGAGCCCTTG
GCCCCAGACGGCGGCTCCCCGGACAGCACCCAGACCAAGGCTGTGCCCCCTGAGGCAAGCCCAGAGAGAAGCTGCTCCCTCCACAGCTGC
CCCCTGGAGGACCCTTCCAGCTCTTCAGGACCCCCACCAACAACTTCCACCCTCCAGCCTGTGGGTCCATCCAGCCCCTTGGCCCCTGCC
CACTTCACCTATCCCCGGGCACTGCAGGAATACCAGGGGGGCAGTTCCCTGCCAGGACTTGGGGATCGGGCAGCTCTCTGCTCCCACGGC
TCCAGCCTCAGCCCTTCTCCAGCCCCCTCACAGCGCGATGGGACCTGGAAGCCACCCGCTGTGCAGCACCATGTGGTCAGCGTCAGGCAG
GAACGAGCCTTCCAGATGCCAAAGAGCTATTCCCAGCTGATTGCTGAGTGGCCAGTGGCCGTGCTGATGCTGTGTCTGGCTGTCATCTTC
CTCTGCACCCTGGCTGGACTGTTGGGGGCCCGGCTGCCCGACTTCTCCAAGCCTTTGCTGGGCTTTGAGCCACGGGACACAGACATTGGG
AGCAAGTTAGTGGTCTGGAGAGCACTACAAGCCCTCACAGGCCCCAGGAAGCTGCTTTTCCTTTCCCCAGACCTTGAGCTGAACAGCTCG
AGCTCCCACAACACTCTGAGGCCTGCACCCAGAGGCAGTGCCCAGGAGAGCGCTGTCCGGCCTCGGAGAATGGTGGAGCCCCTGGAGGAC
AGAAGGCAAGAGAACTTCTTCTGTGGCCCCCCTGAGAAGAGCTATGCAAAGCTGGTGTTCATGTCCACCTCCTCGGGCAGCCTATGGAAC
CTGCATGCCATCCATTCCATGTGTCGCATGGAACAGGACCAGATGGGAATAACTGGGAACACAAGTCCATTTGGACAGCCCTTTAGTCAA
GCTGGAGGGCAGCCAATGGGAGCCACTGGAGTGAACCCCCAGTTAGCCAGCAAACAGAGCATGGTCAACAGTTTGCCCACCTTCCCTACA
GATATCAAGAATACTTCAGTCACCAACGTGCCAAATATGTCTCAGATGCAAACATCAGTGGGAATTGTACCCACACAAGCAATTGCAACA
GGCCCCACTGCAGATCCTGAAAAACGCAAACTGATACAGCAGCAGCTGGTTCTACTGCTTCATGCTCATAAGTGTCAGAGACGAGAGCAA
GCAAACGGAGAGGTTCGGGCCTGCTCGCTCCCGCATTGTCGAACCATGAAAAACGTTTTGAATCACATGACGCATTGTCAGGCTGGGAAA
GCCTGCCAAGTTGCCCATTGTGCATCTTCACGACAAATCATCTCTCATTGGAAGAACTGCACACGACATGACTGTCCTGTTTGCCTCCCT
TTGAAAAATGCCAGTGACAAGCGAAACCAACAAACCATCCTGGGGTCTCCAGCTAGTGGAATTCAAAACACAATTGGTTCTGTTGGCACA
GGGCAACAGAATGCCACTTCTTTAAGTAACCCAAATCCCATAGACCCCAGCTCCATGCAGCGAGCCTATGCTGCTCTCGGACTCCCCTAC
ATGAACCAGCCCCAGACGCAGCTGCAGCCTCAGGTTCCTGGCCAGCAACCAGCACAGCCTCAAACCCACCAGCAGATGAGGACTCTCAAC
CCCCTGGGAAATAATCCAATGAACATTCCAGCAGGAGGAATAACAACAGATCAGCAGCCCCCAAACTTGATTTCAGAATCAGCTCTTCCG
ACTTCCCTGGGGGCCACAAACCCACTGATGAACGATGGCTCCAACTCTGGTAACATTGGAACCCTCAGCACTATACCAACAGCAGCTCCT
CCTTCTAGCACCGGTGTAAGGAAAGGCTGGCACGAACATGTCACTCAGGACCTGCGGAGCCATCTAGTGCATAAACTCGTCCAAGCCATC
TTCCCAACACCTGATCCCGCAGCTCTAAAGGATCGCCGCATGGAAAACCTGGTAGCCTATGCTAAGAAAGTGGAAGGGGACATGTACGAG
TCTGCCAACAGCAGGGATGAATATTATCACTTATTAGCAGAGAAAATCTACAAGATACAAAAAGAACTAGAAGAAAAACGGAGGTCGCGT
TTACATAAACAAGGCATCTTGGGGAACCAGCCAGCCTTACCAGCCCCGGGGGCTCAGCCCCCTGTGATTCCACAGGCACAACCTGTGAGA
CCTCCAAATGGACCCCTGTCCCTGCCAGTGAATCGCATGCAAGTTTCTCAAGGGATGAATTCATTTAACCCCATGTCCTTGGGGAACGTC
CAGTTGCCACAAGCACCCATGGGACCTCGTGCAGCCTCCCCAATGAACCACTCTGTCCAGATGAACAGCATGGGCTCAGTGCCAGGGATG
GCCATTTCTCCTTCCCGAATGCCTCAGCCTCCGAACATGATGGGTGCACACACCAACAACATGATGGCCCAGGCGCCCGCTCAGAGCCAG
TTTCTGCCACAGAACCAGTTCCCGTCATCCAGCGGGGCGATGAGTGTGGGCATGGGGCAGCCGCCAGCCCAAACAGGCGTGTCACAGGGA
CAGGTGCCTGGTGCTGCTCTTCCTAACCCTCTCAACATGCTGGGGCCTCAGGCCAGCCAGCTACCTTGCCCTCCAGTGACACAGTCACCA
CTGCACCCAACACCGCCTCCTGCTTCCACGGCTGCTGGCATGCCATCTCTCCAGCACACGACACCACCTGGGATGACTCCTCCCCAGCCA
GCAGCTCCCACTCAGCCATCAACTCCTGTGTCGTCTTCCGGGCAGACTCCCACCCCGACTCCTGGCTCAGTGCCCAGTGCTACCCAAACC
CAGAGCACCCCTACAGTCCAGGCAGCAGCCCAGGCCCAGGTGACCCCGCAGCCTCAAACCCCAGTTCAGCCCCCGTCTGTGGCTACCCCT
CAGTCATCGCAGCAACAGCCGACGCCTGTGCACGCCCAGCCTCCTGGCACACCGCTTTCCCAGGCAGCAGCCAGCATTGATAACAGAGTC
CCTACCCCCTCCTCGGTGGCCAGCGCAGAAACCAATTCCCAGCAGCCAGGACCTGACGTACCTGTGCTGGAAATGAAGACGGAGACCCAA
GCAGAGGACACTGAGCCCGATCCTGGTGAATCCAAAGGGGAGCCCAGGTCTGAGATGATGGAGGAGGATTTGCAAGGAGCTTCCCAAGTT
AAAGAAGAAACAGACATAGCAGAGCAGAAATCAGAACCAATGGAAGTGGATGAAAAGAAACCTGAAGTGAAAGTAGAAGTTAAAGAGGAA
GAAGAGAGTAGCAGTAACGGCACAGCCTCTCAGTCAACATCTCCTTCGCAGCCGCGCAAAAAAATCTTTAAACCAGAGGAGTTACGCCAG
GCCCTCATGCCAACCCTAGAAGCACTGTATCGACAGGACCCAGAGTCATTACCTTTCCGGCAGCCTGTAGATCCCCAGCTCCTCGGAATT
CCAGACTATTTTGACATCGTAAAGAATCCCATGGACCTCTCCACCATCAAGCGGAAGCTGGACACAGGGCAATACCAAGAGCCCTGGCAG
TACGTGGACGACGTCTGGCTCATGTTCAACAATGCCTGGCTCTATAATCGCAAGACATCCCGAGTCTATAAGTTTTGCAGTAAGCTTGCA
GAGGTCTTTGAGCAGGAAATTGACCCTGTCATGCAGTCCCTTGGATATTGCTGTGGACGCAAGTATGAGTTTTCCCCACAGACTTTGTGC
TGCTATGGGAAGCAGCTGTGTACCATTCCTCGCGATGCTGCCTACTACAGCTATCAGAATAGGTATCATTTCTGTGAGAAGTGTTTCACA
GAGATCCAGGGCGAGAATGTGACCCTGGGTGACGACCCTTCACAGCCCCAGACGACAATTTCAAAGGATCAGTTTGAAAAGAAGAAAAAT
GATACCTTAGACCCCGAACCTTTCGTTGATTGCAAGGAGTGTGGCCGGAAGATGCATCAGATTTGCGTTCTGCACTATGACATCATTTGG
CCTTCAGGTTTTGTGTGCGACAACTGCTTGAAGAAAACTGGCAGACCTCGAAAAGAAAACAAATTCAGTGCTAAGAGGCTGCAGACCACA
AGACTGGGAAACCACTTGGAAGACCGAGTGAACAAATTTTTGCGGCGCCAGAATCACCCTGAAGCCGGGGAGGTTTTTGTCCGAGTGGTG
GCCAGCTCAGACAAGACGGTGGAGGTCAAGCCCGGGATGAAGTCACGGTTTGTGGATTCTGGGGAAATGTCTGAATCTTTCCCATATCGA
ACCAAAGCTCTGTTTGCTTTTGAGGAAATTGACGGCGTGGATGTCTGCTTTTTTGGAATGCACGTCCAAGAATACGGCTCTGATTGCCCC
CCTCCAAACACGAGGCGTGTGTACATTTCTTATCTGGATAGTATTCATTTCTTCCGGCCACGTTGCCTCCGCACAGCCGTTTACCATGAG
ATCCTTATTGGATATTTAGAGTATGTGAAGAAATTAGGGTATGTGACAGGGCACATCTGGGCCTGTCCTCCAAGTGAAGGAGATGATTAC
ATCTTCCATTGCCACCCACCTGATCAAAAAATACCCAAGCCAAAACGACTGCAGGAGTGGTACAAAAAGATGCTGGACAAGGCGTTTGCA
GAGCGGATCATCCATGACTACAAGGATATTTTCAAACAAGCAACTGAAGACAGGCTCACCAGTGCCAAGGAACTGCCCTATTTTGAAGGT
GATTTCTGGCCCAATGTGTTAGAAGAGAGCATTAAGGAACTAGAACAAGAAGAAGAGGAGAGGAAAAAGGAAGAGAGCACTGCAGCCAGT
GAAACCACTGAGGGCAGTCAGGGCGACAGCAAGAATGCCAAGAAGAAGAACAACAAGAAAACCAACAAGAACAAAAGCAGCATCAGCCGC
GCCAACAAGAAGAAGCCCAGCATGCCCAACGTGTCCAATGACCTGTCCCAGAAGCTGTATGCCACCATGGAGAAGCACAAGGAGGTCTTC
TTCGTGATCCACCTGCACGCTGGGCCTGTCATCAACACCCTGCCCCCCATCGTCGACCCCGACCCCCTGCTCAGCTGTGACCTCATGGAT
GGGCGCGACGCCTTCCTCACCCTCGCCAGAGACAAGCACTGGGAGTTCTCCTCCTTGCGCCGCTCCAAGTGGTCCACGCTCTGCATGCTG
GTGGAGCTGCACACCCAGGGCCAGGACCGCTTTGTCTACACCTGCAACGAGTGCAAGCACCACGTGGAGACGCGCTGGCACTGCACTGTG
TGCGAGGACTACGACCTCTGCATCAACTGCTATAACACGAAGAGCCATGCCCATAAGATGGTGAAGTGGGGGCTGGGCCTGGATGACGAG
GGCAGCAGCCAGGGCGAGCCACAGTCAAAGAGCCCCCAGGAGTCACGCCGGCTGAGCATCCAGCGCTGCATCCAGTCGCTGGTGCACGCG
TGCCAGTGCCGCAACGCCAACTGCTCGCTGCCATCCTGCCAGAAGATGAAGCGGGTGGTGCAGCACACCAAGGGCTGCAAACGCAAGACC
AACGGGGGCTGCCCGGTGTGCAAGCAGCTCATCGCCCTCTGCTGCTACCACGCCAAGCACTGCCAAGAAAACAAATGCCCCGTGCCCTTC
TGCCTCAACATCAAACACAAGCTCCGCCAGCAGCAGATCCAGCACCGCCTGCAGCAGGCCCAGCTCATGCGCCGGCGGATGGCCACCATG
AACACCCGCAACGTGCCTCAGCAGAGTCTGCCTTCTCCTACCTCAGCACCGCCCGGGACCCCCACACAGCAGCCCAGCACACCCCAGACG
CCGCAGCCCCCTGCCCAGCCCCAACCCTCACCCGTGAGCATGTCACCAGCTGGCTTCCCCAGCGTGGCCCGGACTCAGCCCCCCACCACG
GTGTCCACAGGGAAGCCTACCAGCCAGGTGCCGGCCCCCCCACCCCCGGCCCAGCCCCCTCCTGCAGCGGTGGAAGCGGCTCGGCAGATC
GAGCGTGAGGCCCAGCAGCAGCAGCACCTGTACCGGGTGAACATCAACAACAGCATGCCCCCAGGACGCACGGGCATGGGGACCCCGGGG
AGCCAGATGGCCCCCGTGAGCCTGAATGTGCCCCGACCCAACCAGGTGAGCGGGCCCGTCATGCCCAGCATGCCTCCCGGGCAGTGGCAG
CAGGCGCCCCTTCCCCAGCAGCAGCCCATGCCAGGCTTGCCCAGGCCTGTGATATCCATGCAGGCCCAGGCGGCCGTGGCTGGGCCCCGG
ATGCCCAGCGTGCAGCCACCCAGGAGCATCTCACCCAGCGCTCTGCAAGACCTGCTGCGGACCCTGAAGTCGCCCAGCTCCCCTCAGCAG
CAACAGCAGGTGCTGAACATTCTCAAATCAAACCCGCAGCTAATGGCAGCTTTCATCAAACAGCGCACAGCCAAGTACGTGGCCAATCAG
CCCGGCATGCAGCCCCAGCCTGGCCTCCAGTCCCAGCCCGGCATGCAACCCCAGCCTGGCATGCACCAGCAGCCCAGCCTGCAGAACCTG
AATGCCATGCAGGCTGGCGTGCCGCGGCCCGGTGTGCCTCCACAGCAGCAGGCGATGGGAGGCCTGAACCCCCAGGGCCAGGCCTTGAAC
ATCATGAACCCAGGACACAACCCCAACATGGCGAGTATGAATCCACAGTACCGAGAAATGTTACGGAGGCAGCTGCTGCAGCAGCAGCAG
CAACAGCAGCAGCAACAACAGCAGCAACAGCAGCAGCAGCAAGGGAGTGCCGGCATGGCTGGGGGCATGGCGGGGCACGGCCAGTTCCAG
CAGCCTCAAGGACCCGGAGGCTACCCACCGGCCATGCAGCAGCAGCAGCGCATGCAGCAGCATCTCCCCCTCCAGGGCAGCTCCATGGGC
CAGATGGCGGCTCAGATGGGACAGCTTGGCCAGATGGGGCAGCCGGGGCTGGGGGCAGACAGCACCCCCAACATCCAGCAAGCCCTGCAG
CAGCGGATTCTGCAGCAACAGCAGATGAAGCAGCAGATTGGGTCCCCAGGCCAGCCGAACCCCATGAGCCCCCAGCAACACATGCTCTCA
GGACAGCCACAGGCCTCGCATCTCCCTGGCCAGCAGATCGCCACGTCCCTTAGTAACCAGGTGCGGTCTCCAGCCCCTGTCCAGTCTCCA
CGGCCCCAGTCCCAGCCTCCACATTCCAGCCCGTCACCACGGATACAGCCCCAGCCTTCGCCACACCACGTCTCACCCCAGACTGGTTCC
CCCCACCCCGGACTCGCAGTCACCATGGCCAGCTCCATAGATCAGGGACACTTGGGGAACCCCGAACAGAGTGCAATGCTCCCCCAGCTG
AACACCCCCAGCAGGAGTGCGCTGTCCAGCGAACTGTCCCTGGTCGGGGACACCACGGGGGACACGCTAGAGAAGTTTGTGGAGGGCTTG
TAGCATTGTGAGAGCATCACCTTTTCCCTTTCATGTTCTTGGACCTTTTGTACTGAAAATCCAGGCATCTAGGTTCTTTTTATTCCTAGA
TGGAACTGCGACTTCCGAGCCATGGAAGGGTGGATTGATGTTTAAAGAAACAATACAAAGAATATATTTTTTTGTTAAAAACCAGTTGAT
TTAAATATCTGGTCTCTCTCTTTGGTTTTTTTTTGGCGGGGGGGTGGGGGGGGTTCTTTTTTTTCCGTTTTGTTTTTGTTTGGGGGGAGG
GGGGTTTTGTTTGGATTCTTTTTGTCGTCATTGCTGGTGACTCATGCCTTTTTTTAACGGGAAAAACAAGTTCATTATATTCATATTTTT
TATTTGTATTTTCAAGACTTTAAACATTTATGTTTAAAAGTAAGAAGAAAAATAATATTCAGAACTGATTCCTGAAATAATGCAAGCTTA
TAATGTATCCCGATAACTTTGTGATGTTTCGGGAAGATTTTTTTCTATAGTGAACTCTGTGGGCGTCTCCCAGTATTACCCTGGATGATA
GGAATTGACTCCGGCGTGCACACACGTACACACCCACACACATCTATCTATACATAATGGCTGAAGCCAAACTTGTCTTGCAGATGTAGA
AATTGTTGCTTTGTTTCTCTGATAAAACTGGTTTTAGACAAAAAATAGGGATGATCACTCTTAGACCATGCTAATGTTACTAGAGAAGAA
GCCTTCTTTTCTTTCTTCTATGTGAAACTTGAAATGAGGAAAAGCAATTCTAGTGTAAATCATGCAAGCGCTCTAATTCCTATAAATACG
AAACTCGAGAAGATTCAATCACTGTATAGAATGGTAAAATACCAACTCATTTCTTATATCATATTGTTAAATAAACTGTGTGCAACAGAC
AAAAAGGGTGGTCCTTCTTGAATTCATGTACATGGTATTAACACTTAGTGTTCGGGGTTTTTTGTTATGAAAATGCTGTTTTCAACATTG
TATTTGGACTATGCATGTGTTTTTTCCCCATTGTATATAAAGTACCGCTTAAAATTGATATAAATTACTGAGGTTTTTAACATGTATTCT
GTTCTTTAAGATCCCTGTAAGAATGTTTAAGGTTTTTATTTATTTATATATATTTTTTGAGTCTGTTCTTTGTAAGACATGGTTCTGGTT
GTTCGCTCATAGCGGAGAGGCTGGGGCTGCGGTTGTGGTTGTGGCGGCGTGGGTGGTGGCTGGGAACTGTGGCCCAGGCTTAGCGGCCGC
CCGGAGGCTTTTCTTCCCGGAGACTGAGGTGGGCGACTGAGGTGGGCGGCTCAGCGTTGGCCCCACACATTCGAGGCTCACAGGTGATTG
TCGCTCACACAGTTAGGGTCGTCAGTTGGTCTGAAACTGCATTTGGCCCACTCCTCCATCCTCCCTGTCCGTCGTAGCTGCCACCCCCAG
AGGCGGCGCTTCTTCCCGTGTTCAGGCGGCTCCCCCCCCCCGTACACGACTCCCAGAATCTGAGGCAGAGAGTGCTCCAGGCTCGCGAGG
TGCTTTCTGACTTCCCCCCAAATCCTGCCGCTGCCGCGCAGCATGTCCCGTGTGGCGTTTGAGGAAATGCTGAGGGACAGACACCTTGGA
GCACCAGCTCCGGTCCCTGTTACAGTGAGAAAGGTCCCCCACTTCGGGGGATACTTGCACTTAGCCACATGGTCCTGCCTCCCTTGGAGT
CCAGTTCCAGGCTCCCTTACTGAGTGGGTGAGACAAGTTCACAAAAACCGTAAAACTGAGAGGAGGACCATGGGCAGGGGAGCTGAAGTT
CATCCCCTAAGTCTACCACCCCCAGCACCCAGAGAACCCACTTTATCCCTAGTCCCCCAACAAAGGCTGGTCTAGGTGGGGGTGATGGTA
ATTTTAGAAATCACGCCCCAAATAGCTTCCGTTTGGGCCCTTACATTCACAGATAGGTTTTAAATAGCTGAATACTTGGTTTGGGAATCT
GAATTCGAGGAACCTTTCTAAGAAGTTGGAAAGGTCCGATCTAGTTTTAGCACAGAGCTTTGAACCTTGAGTTATAAAATGCAGAATAAT
TCAAGTAAAAATAAGACCACCATCTGGCACCCCTGACCAGCCCCCATTCACCCCATCCCAGGAGGGGAAGCACAGGCCGGGCCTCCGGTG
GAGATTGCTGCCACTGCTCGGCCTGCTGGGTTCTTAACCTCCAGTGTCCTCTTCATCTTTTCCACCCGTAGGGAAACCTTGAGCCATGTG
TTCAAACAAGAAGTGGGGCTAGAGCCCGAGAGCAGCAGCTCTAAGCCCACACTCAGAAAGTGGCGCCCTCCTGGTTGTGCAGCCTTTTAA
TGTGGGCAGTGGAGGGGCCTCTGTTTCAGGTTATCCTGGAATTCAAAACGTTATGTACCAACCTCATCCTCTTTGGAGTCTGCATCCTGT
GCAACCGTCTTGGGCAATCCAGATGTCGAAGGATGTGACCGAGAGCATGGTCTGTGGATGCTAACCCTAAGTTTGTCGTAAGGAAATTTC
TGTAAGAAACCTGGAAAGCCCCAACGCTGTGTCTCATGCTGTATACTTAAGAGGAGAAGAAAAAGTCCTATATTTGTGATCAAAAAGAGG

>22945_22945_1_DISP2-CREBBP_DISP2_chr15_40657926_ENST00000267889_CREBBP_chr16_3860780_ENST00000262367_length(amino acids)=2491AA_BP=314
MDGDSSSSSGGSGPAPGPGPEGEQRPEGEPLAPDGGSPDSTQTKAVPPEASPERSCSLHSCPLEDPSSSSGPPPTTSTLQPVGPSSPLAP
AHFTYPRALQEYQGGSSLPGLGDRAALCSHGSSLSPSPAPSQRDGTWKPPAVQHHVVSVRQERAFQMPKSYSQLIAEWPVAVLMLCLAVI
FLCTLAGLLGARLPDFSKPLLGFEPRDTDIGSKLVVWRALQALTGPRKLLFLSPDLELNSSSSHNTLRPAPRGSAQESAVRPRRMVEPLE
DRRQENFFCGPPEKSYAKLVFMSTSSGSLWNLHAIHSMCRMEQDQMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFP
TDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAG
KACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLP
YMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAA
PPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRS
RLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPG
MAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQS
PLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVAT
PQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQ
VKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLG
IPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTL
CCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDII
WPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPY
RTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDD
YIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAA
SETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLM
DGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDD
EGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVP
FCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPT
TVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQW
QQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVAN
QPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQ
QQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQAL
QQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTG

--------------------------------------------------------------
>22945_22945_2_DISP2-CREBBP_DISP2_chr15_40657926_ENST00000267889_CREBBP_chr16_3860780_ENST00000382070_length(transcript)=7628nt_BP=1032nt
CGCCGCCGCTGCCGCCGCCACCGCCGCCGCCGCCGCCGCCGCCGCGGCTTCAGCACCAGCGCCCGGACAGCGGTGCCGCCCACGGGCATG
GACGGTGACAGCAGCAGCAGCAGCGGCGGCAGCGGTCCGGCTCCCGGCCCGGGTCCGGAAGGGGAGCAACGGCCCGAGGGGGAGCCCTTG
GCCCCAGACGGCGGCTCCCCGGACAGCACCCAGACCAAGGCTGTGCCCCCTGAGGCAAGCCCAGAGAGAAGCTGCTCCCTCCACAGCTGC
CCCCTGGAGGACCCTTCCAGCTCTTCAGGACCCCCACCAACAACTTCCACCCTCCAGCCTGTGGGTCCATCCAGCCCCTTGGCCCCTGCC
CACTTCACCTATCCCCGGGCACTGCAGGAATACCAGGGGGGCAGTTCCCTGCCAGGACTTGGGGATCGGGCAGCTCTCTGCTCCCACGGC
TCCAGCCTCAGCCCTTCTCCAGCCCCCTCACAGCGCGATGGGACCTGGAAGCCACCCGCTGTGCAGCACCATGTGGTCAGCGTCAGGCAG
GAACGAGCCTTCCAGATGCCAAAGAGCTATTCCCAGCTGATTGCTGAGTGGCCAGTGGCCGTGCTGATGCTGTGTCTGGCTGTCATCTTC
CTCTGCACCCTGGCTGGACTGTTGGGGGCCCGGCTGCCCGACTTCTCCAAGCCTTTGCTGGGCTTTGAGCCACGGGACACAGACATTGGG
AGCAAGTTAGTGGTCTGGAGAGCACTACAAGCCCTCACAGGCCCCAGGAAGCTGCTTTTCCTTTCCCCAGACCTTGAGCTGAACAGCTCG
AGCTCCCACAACACTCTGAGGCCTGCACCCAGAGGCAGTGCCCAGGAGAGCGCTGTCCGGCCTCGGAGAATGGTGGAGCCCCTGGAGGAC
AGAAGGCAAGAGAACTTCTTCTGTGGCCCCCCTGAGAAGAGCTATGCAAAGCTGGTGTTCATGTCCACCTCCTCGGGCAGCCTATGGAAC
CTGCATGCCATCCATTCCATGTGTCGCATGGAACAGGACCAGATGGGAATAACTGGGAACACAAGTCCATTTGGACAGCCCTTTAGTCAA
GCTGGAGGGCAGCCAATGGGAGCCACTGGAGTGAACCCCCAGTTAGCCAGCAAACAGAGCATGGTCAACAGTTTGCCCACCTTCCCTACA
GATATCAAGAATACTTCAGTCACCAACGTGCCAAATATGTCTCAGATGCAAACATCAGTGGGAATTGTACCCACACAAGCAATTGCAACA
GGCCCCACTGCAGATCCTGAAAAACGCAAACTGATACAGCAGCAGCTGGTTCTACTGCTTCATGCTCATAAGTGTCAGAGACGAGAGCAA
GCAAACGGAGAGGTTCGGGCCTGCTCGCTCCCGCATTGTCGAACCATGAAAAACGTTTTGAATCACATGACGCATTGTCAGGCTGGGAAA
GCCTGCCAAGCCATCCTGGGGTCTCCAGCTAGTGGAATTCAAAACACAATTGGTTCTGTTGGCACAGGGCAACAGAATGCCACTTCTTTA
AGTAACCCAAATCCCATAGACCCCAGCTCCATGCAGCGAGCCTATGCTGCTCTCGGACTCCCCTACATGAACCAGCCCCAGACGCAGCTG
CAGCCTCAGGTTCCTGGCCAGCAACCAGCACAGCCTCAAACCCACCAGCAGATGAGGACTCTCAACCCCCTGGGAAATAATCCAATGAAC
ATTCCAGCAGGAGGAATAACAACAGATCAGCAGCCCCCAAACTTGATTTCAGAATCAGCTCTTCCGACTTCCCTGGGGGCCACAAACCCA
CTGATGAACGATGGCTCCAACTCTGGTAACATTGGAACCCTCAGCACTATACCAACAGCAGCTCCTCCTTCTAGCACCGGTGTAAGGAAA
GGCTGGCACGAACATGTCACTCAGGACCTGCGGAGCCATCTAGTGCATAAACTCGTCCAAGCCATCTTCCCAACACCTGATCCCGCAGCT
CTAAAGGATCGCCGCATGGAAAACCTGGTAGCCTATGCTAAGAAAGTGGAAGGGGACATGTACGAGTCTGCCAACAGCAGGGATGAATAT
TATCACTTATTAGCAGAGAAAATCTACAAGATACAAAAAGAACTAGAAGAAAAACGGAGGTCGCGTTTACATAAACAAGGCATCTTGGGG
AACCAGCCAGCCTTACCAGCCCCGGGGGCTCAGCCCCCTGTGATTCCACAGGCACAACCTGTGAGACCTCCAAATGGACCCCTGTCCCTG
CCAGTGAATCGCATGCAAGTTTCTCAAGGGATGAATTCATTTAACCCCATGTCCTTGGGGAACGTCCAGTTGCCACAAGCACCCATGGGA
CCTCGTGCAGCCTCCCCAATGAACCACTCTGTCCAGATGAACAGCATGGGCTCAGTGCCAGGGATGGCCATTTCTCCTTCCCGAATGCCT
CAGCCTCCGAACATGATGGGTGCACACACCAACAACATGATGGCCCAGGCGCCCGCTCAGAGCCAGTTTCTGCCACAGAACCAGTTCCCG
TCATCCAGCGGGGCGATGAGTGTGGGCATGGGGCAGCCGCCAGCCCAAACAGGCGTGTCACAGGGACAGGTGCCTGGTGCTGCTCTTCCT
AACCCTCTCAACATGCTGGGGCCTCAGGCCAGCCAGCTACCTTGCCCTCCAGTGACACAGTCACCACTGCACCCAACACCGCCTCCTGCT
TCCACGGCTGCTGGCATGCCATCTCTCCAGCACACGACACCACCTGGGATGACTCCTCCCCAGCCAGCAGCTCCCACTCAGCCATCAACT
CCTGTGTCGTCTTCCGGGCAGACTCCCACCCCGACTCCTGGCTCAGTGCCCAGTGCTACCCAAACCCAGAGCACCCCTACAGTCCAGGCA
GCAGCCCAGGCCCAGGTGACCCCGCAGCCTCAAACCCCAGTTCAGCCCCCGTCTGTGGCTACCCCTCAGTCATCGCAGCAACAGCCGACG
CCTGTGCACGCCCAGCCTCCTGGCACACCGCTTTCCCAGGCAGCAGCCAGCATTGATAACAGAGTCCCTACCCCCTCCTCGGTGGCCAGC
GCAGAAACCAATTCCCAGCAGCCAGGACCTGACGTACCTGTGCTGGAAATGAAGACGGAGACCCAAGCAGAGGACACTGAGCCCGATCCT
GGTGAATCCAAAGGGGAGCCCAGGTCTGAGATGATGGAGGAGGATTTGCAAGGAGCTTCCCAAGTTAAAGAAGAAACAGACATAGCAGAG
CAGAAATCAGAACCAATGGAAGTGGATGAAAAGAAACCTGAAGTGAAAGTAGAAGTTAAAGAGGAAGAAGAGAGTAGCAGTAACGGCACA
GCCTCTCAGTCAACATCTCCTTCGCAGCCGCGCAAAAAAATCTTTAAACCAGAGGAGTTACGCCAGGCCCTCATGCCAACCCTAGAAGCA
CTGTATCGACAGGACCCAGAGTCATTACCTTTCCGGCAGCCTGTAGATCCCCAGCTCCTCGGAATTCCAGACTATTTTGACATCGTAAAG
AATCCCATGGACCTCTCCACCATCAAGCGGAAGCTGGACACAGGGCAATACCAAGAGCCCTGGCAGTACGTGGACGACGTCTGGCTCATG
TTCAACAATGCCTGGCTCTATAATCGCAAGACATCCCGAGTCTATAAGTTTTGCAGTAAGCTTGCAGAGGTCTTTGAGCAGGAAATTGAC
CCTGTCATGCAGTCCCTTGGATATTGCTGTGGACGCAAGTATGAGTTTTCCCCACAGACTTTGTGCTGCTATGGGAAGCAGCTGTGTACC
ATTCCTCGCGATGCTGCCTACTACAGCTATCAGAATAGGTATCATTTCTGTGAGAAGTGTTTCACAGAGATCCAGGGCGAGAATGTGACC
CTGGGTGACGACCCTTCACAGCCCCAGACGACAATTTCAAAGGATCAGTTTGAAAAGAAGAAAAATGATACCTTAGACCCCGAACCTTTC
GTTGATTGCAAGGAGTGTGGCCGGAAGATGCATCAGATTTGCGTTCTGCACTATGACATCATTTGGCCTTCAGGTTTTGTGTGCGACAAC
TGCTTGAAGAAAACTGGCAGACCTCGAAAAGAAAACAAATTCAGTGCTAAGAGGCTGCAGACCACAAGACTGGGAAACCACTTGGAAGAC
CGAGTGAACAAATTTTTGCGGCGCCAGAATCACCCTGAAGCCGGGGAGGTTTTTGTCCGAGTGGTGGCCAGCTCAGACAAGACGGTGGAG
GTCAAGCCCGGGATGAAGTCACGGTTTGTGGATTCTGGGGAAATGTCTGAATCTTTCCCATATCGAACCAAAGCTCTGTTTGCTTTTGAG
GAAATTGACGGCGTGGATGTCTGCTTTTTTGGAATGCACGTCCAAGAATACGGCTCTGATTGCCCCCCTCCAAACACGAGGCGTGTGTAC
ATTTCTTATCTGGATAGTATTCATTTCTTCCGGCCACGTTGCCTCCGCACAGCCGTTTACCATGAGATCCTTATTGGATATTTAGAGTAT
GTGAAGAAATTAGGGTATGTGACAGGGCACATCTGGGCCTGTCCTCCAAGTGAAGGAGATGATTACATCTTCCATTGCCACCCACCTGAT
CAAAAAATACCCAAGCCAAAACGACTGCAGGAGTGGTACAAAAAGATGCTGGACAAGGCGTTTGCAGAGCGGATCATCCATGACTACAAG
GATATTTTCAAACAAGCAACTGAAGACAGGCTCACCAGTGCCAAGGAACTGCCCTATTTTGAAGGTGATTTCTGGCCCAATGTGTTAGAA
GAGAGCATTAAGGAACTAGAACAAGAAGAAGAGGAGAGGAAAAAGGAAGAGAGCACTGCAGCCAGTGAAACCACTGAGGGCAGTCAGGGC
GACAGCAAGAATGCCAAGAAGAAGAACAACAAGAAAACCAACAAGAACAAAAGCAGCATCAGCCGCGCCAACAAGAAGAAGCCCAGCATG
CCCAACGTGTCCAATGACCTGTCCCAGAAGCTGTATGCCACCATGGAGAAGCACAAGGAGGTCTTCTTCGTGATCCACCTGCACGCTGGG
CCTGTCATCAACACCCTGCCCCCCATCGTCGACCCCGACCCCCTGCTCAGCTGTGACCTCATGGATGGGCGCGACGCCTTCCTCACCCTC
GCCAGAGACAAGCACTGGGAGTTCTCCTCCTTGCGCCGCTCCAAGTGGTCCACGCTCTGCATGCTGGTGGAGCTGCACACCCAGGGCCAG
GACCGCTTTGTCTACACCTGCAACGAGTGCAAGCACCACGTGGAGACGCGCTGGCACTGCACTGTGTGCGAGGACTACGACCTCTGCATC
AACTGCTATAACACGAAGAGCCATGCCCATAAGATGGTGAAGTGGGGGCTGGGCCTGGATGACGAGGGCAGCAGCCAGGGCGAGCCACAG
TCAAAGAGCCCCCAGGAGTCACGCCGGCTGAGCATCCAGCGCTGCATCCAGTCGCTGGTGCACGCGTGCCAGTGCCGCAACGCCAACTGC
TCGCTGCCATCCTGCCAGAAGATGAAGCGGGTGGTGCAGCACACCAAGGGCTGCAAACGCAAGACCAACGGGGGCTGCCCGGTGTGCAAG
CAGCTCATCGCCCTCTGCTGCTACCACGCCAAGCACTGCCAAGAAAACAAATGCCCCGTGCCCTTCTGCCTCAACATCAAACACAAGCTC
CGCCAGCAGCAGATCCAGCACCGCCTGCAGCAGGCCCAGCTCATGCGCCGGCGGATGGCCACCATGAACACCCGCAACGTGCCTCAGCAG
AGTCTGCCTTCTCCTACCTCAGCACCGCCCGGGACCCCCACACAGCAGCCCAGCACACCCCAGACGCCGCAGCCCCCTGCCCAGCCCCAA
CCCTCACCCGTGAGCATGTCACCAGCTGGCTTCCCCAGCGTGGCCCGGACTCAGCCCCCCACCACGGTGTCCACAGGGAAGCCTACCAGC
CAGGTGCCGGCCCCCCCACCCCCGGCCCAGCCCCCTCCTGCAGCGGTGGAAGCGGCTCGGCAGATCGAGCGTGAGGCCCAGCAGCAGCAG
CACCTGTACCGGGTGAACATCAACAACAGCATGCCCCCAGGACGCACGGGCATGGGGACCCCGGGGAGCCAGATGGCCCCCGTGAGCCTG
AATGTGCCCCGACCCAACCAGGTGAGCGGGCCCGTCATGCCCAGCATGCCTCCCGGGCAGTGGCAGCAGGCGCCCCTTCCCCAGCAGCAG
CCCATGCCAGGCTTGCCCAGGCCTGTGATATCCATGCAGGCCCAGGCGGCCGTGGCTGGGCCCCGGATGCCCAGCGTGCAGCCACCCAGG
AGCATCTCACCCAGCGCTCTGCAAGACCTGCTGCGGACCCTGAAGTCGCCCAGCTCCCCTCAGCAGCAACAGCAGGTGCTGAACATTCTC
AAATCAAACCCGCAGCTAATGGCAGCTTTCATCAAACAGCGCACAGCCAAGTACGTGGCCAATCAGCCCGGCATGCAGCCCCAGCCTGGC
CTCCAGTCCCAGCCCGGCATGCAACCCCAGCCTGGCATGCACCAGCAGCCCAGCCTGCAGAACCTGAATGCCATGCAGGCTGGCGTGCCG
CGGCCCGGTGTGCCTCCACAGCAGCAGGCGATGGGAGGCCTGAACCCCCAGGGCCAGGCCTTGAACATCATGAACCCAGGACACAACCCC
AACATGGCGAGTATGAATCCACAGTACCGAGAAATGTTACGGAGGCAGCTGCTGCAGCAGCAGCAGCAACAGCAGCAGCAACAACAGCAG
CAACAGCAGCAGCAGCAAGGGAGTGCCGGCATGGCTGGGGGCATGGCGGGGCACGGCCAGTTCCAGCAGCCTCAAGGACCCGGAGGCTAC
CCACCGGCCATGCAGCAGCAGCAGCGCATGCAGCAGCATCTCCCCCTCCAGGGCAGCTCCATGGGCCAGATGGCGGCTCAGATGGGACAG
CTTGGCCAGATGGGGCAGCCGGGGCTGGGGGCAGACAGCACCCCCAACATCCAGCAAGCCCTGCAGCAGCGGATTCTGCAGCAACAGCAG
ATGAAGCAGCAGATTGGGTCCCCAGGCCAGCCGAACCCCATGAGCCCCCAGCAACACATGCTCTCAGGACAGCCACAGGCCTCGCATCTC
CCTGGCCAGCAGATCGCCACGTCCCTTAGTAACCAGGTGCGGTCTCCAGCCCCTGTCCAGTCTCCACGGCCCCAGTCCCAGCCTCCACAT
TCCAGCCCGTCACCACGGATACAGCCCCAGCCTTCGCCACACCACGTCTCACCCCAGACTGGTTCCCCCCACCCCGGACTCGCAGTCACC
ATGGCCAGCTCCATAGATCAGGGACACTTGGGGAACCCCGAACAGAGTGCAATGCTCCCCCAGCTGAACACCCCCAGCAGGAGTGCGCTG
TCCAGCGAACTGTCCCTGGTCGGGGACACCACGGGGGACACGCTAGAGAAGTTTGTGGAGGGCTTGTAGCATTGTGAGAGCATCACCTTT
TCCCTTTCATGTTCTTGGACCTTTTGTACTGAAAATCCAGGCATCTAGGTTCTTTTTATTCCTAGATGGAACTGCGACTTCCGAGCCATG

>22945_22945_2_DISP2-CREBBP_DISP2_chr15_40657926_ENST00000267889_CREBBP_chr16_3860780_ENST00000382070_length(amino acids)=2453AA_BP=314
MDGDSSSSSGGSGPAPGPGPEGEQRPEGEPLAPDGGSPDSTQTKAVPPEASPERSCSLHSCPLEDPSSSSGPPPTTSTLQPVGPSSPLAP
AHFTYPRALQEYQGGSSLPGLGDRAALCSHGSSLSPSPAPSQRDGTWKPPAVQHHVVSVRQERAFQMPKSYSQLIAEWPVAVLMLCLAVI
FLCTLAGLLGARLPDFSKPLLGFEPRDTDIGSKLVVWRALQALTGPRKLLFLSPDLELNSSSSHNTLRPAPRGSAQESAVRPRRMVEPLE
DRRQENFFCGPPEKSYAKLVFMSTSSGSLWNLHAIHSMCRMEQDQMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFP
TDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAG
KACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPM
NIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPA
ALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLS
LPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQF
PSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPS
TPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVA
SAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNG
TASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWL
MFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENV
TLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLE
DRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRV
YISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDY
KDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPS
MPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQG
QDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNAN
CSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQ
QSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQ
QHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPP
RSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGV
PRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGG
YPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASH
LPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSA

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Fusion Gene PPI Analysis for DISP2-CREBBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311162_1180266.02443.0ASF1A
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301162_1180266.02405.0ASF1A
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311433_1435266.02443.0histone
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301433_1435266.02405.0histone
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311124_1170266.02443.0histone
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301124_1170266.02405.0histone
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311460_1891266.02443.0TRERF1
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301460_1891266.02405.0TRERF1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCREBBPchr15:40657926chr16:3860780ENST00000262367131227_410266.02443.0SRCAP
TgeneCREBBPchr15:40657926chr16:3860780ENST00000382070130227_410266.02405.0SRCAP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DISP2-CREBBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DISP2-CREBBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4551859RUBINSTEIN-TAYBI SYNDROME 112CLINGEN;GENOMICS_ENGLAND;UNIPROT
TgeneC0035934Rubinstein-Taybi Syndrome6CLINGEN;CTD_human
TgeneC0033578Prostatic Neoplasms2CTD_human
TgeneC0376358Malignant neoplasm of prostate2CTD_human
TgeneC4511003Acute myeloid leukemia with t(8;16)(p11;p13) translocation2ORPHANET
TgeneC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneC0005695Bladder Neoplasm1CTD_human
TgeneC0007137Squamous cell carcinoma1CTD_human
TgeneC0007138Carcinoma, Transitional Cell1CTD_human
TgeneC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneC0011573Endogenous depression1PSYGENET
TgeneC0024301Lymphoma, Follicular1CTD_human
TgeneC0036920Sezary Syndrome1CTD_human
TgeneC0079745Lymphoma, Large-Cell, Follicular1CTD_human
TgeneC0079758Lymphoma, Mixed-Cell, Follicular1CTD_human
TgeneC0079765Lymphoma, Small Cleaved-Cell, Follicular1CTD_human
TgeneC0149925Small cell carcinoma of lung1CTD_human
TgeneC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneC1956130Lymphoma, Follicular, Grade 11CTD_human
TgeneC1956131Lymphoma, Follicular, Grade 31CTD_human
TgeneC1956132Lymphoma, Follicular, Grade 21CTD_human
TgeneC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human