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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DIXDC1-ARCN1 (FusionGDB2 ID:HG85458TG372)

Fusion Gene Summary for DIXDC1-ARCN1

check button Fusion gene summary
Fusion gene informationFusion gene name: DIXDC1-ARCN1
Fusion gene ID: hg85458tg372
HgeneTgene
Gene symbol

DIXDC1

ARCN1

Gene ID

85458

372

Gene nameDIX domain containing 1archain 1
SynonymsCCD1COPD|SRMMD
Cytomap('DIXDC1')('ARCN1')

11q23.1

11q23.3

Type of geneprotein-codingprotein-coding
Descriptiondixincoiled-coil protein DIX1coatomer subunit deltaCOPI coat complex subunit deltaarchain vesicle transport protein 1coatomer delta subunitcoatomer protein complex, subunit deltacoatomer protein delta-COPdelta-COPdelta-coat protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000389821, ENST00000440460, 
ENST00000531396, ENST00000315253, 
ENST00000529225, 
Fusion gene scores* DoF score7 X 6 X 4=16810 X 10 X 5=500
# samples 911
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/500*10)=-2.18442457113743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DIXDC1 [Title/Abstract] AND ARCN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDIXDC1(111808283)-ARCN1(118463424), # samples:2
Anticipated loss of major functional domain due to fusion event.DIXDC1-ARCN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DIXDC1-ARCN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DIXDC1-ARCN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DIXDC1-ARCN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDIXDC1

GO:0060070

canonical Wnt signaling pathway

21189423


check buttonFusion gene breakpoints across DIXDC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ARCN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-2084-01ADIXDC1chr11

111808283

+ARCN1chr11

118463424

+


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Fusion Gene ORF analysis for DIXDC1-ARCN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000389821ENST00000359415DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
3UTR-3CDSENST00000389821ENST00000392859DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
3UTR-intronENST00000389821ENST00000264028DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
3UTR-intronENST00000389821ENST00000534182DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
5CDS-intronENST00000440460ENST00000264028DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
5CDS-intronENST00000440460ENST00000534182DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
5CDS-intronENST00000531396ENST00000264028DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
5CDS-intronENST00000531396ENST00000534182DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
In-frameENST00000440460ENST00000359415DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
In-frameENST00000440460ENST00000392859DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
In-frameENST00000531396ENST00000359415DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
In-frameENST00000531396ENST00000392859DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
intron-3CDSENST00000315253ENST00000359415DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
intron-3CDSENST00000315253ENST00000392859DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
intron-3CDSENST00000529225ENST00000359415DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
intron-3CDSENST00000529225ENST00000392859DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
intron-intronENST00000315253ENST00000264028DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
intron-intronENST00000315253ENST00000534182DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
intron-intronENST00000529225ENST00000264028DIXDC1chr11

111808283

+ARCN1chr11

118463424

+
intron-intronENST00000529225ENST00000534182DIXDC1chr11

111808283

+ARCN1chr11

118463424

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000440460DIXDC1chr11111808283+ENST00000392859ARCN1chr11118463424+118835776047237
ENST00000440460DIXDC1chr11111808283+ENST00000359415ARCN1chr11118463424+312335776047237
ENST00000531396DIXDC1chr11111808283+ENST00000392859ARCN1chr11118463424+96413337684215
ENST00000531396DIXDC1chr11111808283+ENST00000359415ARCN1chr11118463424+289913337684215

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000440460ENST00000392859DIXDC1chr11111808283+ARCN1chr11118463424+0.0071419570.99285805
ENST00000440460ENST00000359415DIXDC1chr11111808283+ARCN1chr11118463424+0.0015360220.998464
ENST00000531396ENST00000392859DIXDC1chr11111808283+ARCN1chr11118463424+0.0057442060.99425584
ENST00000531396ENST00000359415DIXDC1chr11111808283+ARCN1chr11118463424+0.0011790720.99882096

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Fusion Genomic Features for DIXDC1-ARCN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DIXDC1chr11111808283+ARCN1chr11118463423+7.81E-070.99999917
DIXDC1chr11111808283+ARCN1chr11118463423+7.81E-070.99999917

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DIXDC1-ARCN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:111808283/chr11:118463424)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARCN1chr11:111808283chr11:118463424ENST0000039285949271_511240424.0DomainMHD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDIXDC1chr11:111808283chr11:118463424ENST00000531396+15279_45220220.0Coiled coilOntology_term=ECO:0000255
HgeneDIXDC1chr11:111808283chr11:118463424ENST00000531396+1520_12720220.0DomainCalponin-homology (CH)
HgeneDIXDC1chr11:111808283chr11:118463424ENST00000531396+15600_68020220.0DomainDIX
HgeneDIXDC1chr11:111808283chr11:118463424ENST00000531396+15127_30020220.0RegionNote=Actin-binding
TgeneARCN1chr11:111808283chr11:118463424ENST00000264028510271_511328512.0DomainMHD


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Fusion Gene Sequence for DIXDC1-ARCN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22949_22949_1_DIXDC1-ARCN1_DIXDC1_chr11_111808283_ENST00000440460_ARCN1_chr11_118463424_ENST00000359415_length(transcript)=3123nt_BP=357nt
TCCCGCAGGAAAGCGGGGCTGGGGGCAGCCCGGCAGCGCCGCTCAACCTAGTGCGCGCCCAGTTGTTTCCATAGGAACCGCGACCGCGCC
GGGCCCCTCCAGCGGAGGCCCCCGTGCGAGCATGCCCAGTGCAAGCCGCTAGTTTGGCTCCAGTCTAGGTTTCCAGTAAGTGGCATGCGG
GACTCCGGAGGGATCCCAATGAGCTGAGCCGAGAGCCTTTGTGTGCAGAGGGAGGAGGAGGAGGCGGCGGCGGCCGCCGGGCTGGAGACC
CCGCCCGGGGAGCCCCCAGCAGGAACAATGCTAGCCTGCCTGACCCGAGGGAACTTACTGGACGTCCTGCAGGAGGGCTTCAATGAGACC
CATCCAAATGTGGATAAAAAACTTTTCACTGCAGAGTCTCTAATTGGCCTGAAGAATCCAGAGAAGTCATTTCCAGTCAACAGTGACGTA
GGGGTGCTAAAGTGGAGACTACAAACCACAGAGGAATCTTTTATTCCACTGACAATTAATTGCTGGCCCTCGGAGAGTGGAAATGGCTGT
GATGTCAACATAGAATATGAGCTACAAGAAGATAATTTAGAACTGAATGATGTGGTTATCACCATCCCACTCCCGTCTGGTGTCGGCGCG
CCTGTTATCGGTGAGATCGATGGGGAGTATCGACATGACAGTCGACGAAATACCCTGGAGTGGTGCCTGCCTGTGATTGATGCCAAAAAT
AAGAGTGGCAGCCTGGAGTTTAGCATTGCTGGGCAGCCCAATGACTTCTTCCCTGTTCAAGTTTCCTTTGTCTCCAAGAAAAATTACTGT
AACATACAGGTTACCAAAGTGACCCAGGTAGATGGAAACAGCCCCGTCAGGTTTTCCACAGAGACCACTTTCCTAGTGGATAAGTATGAA
ATTCTGTAATACCAAGAAGAGGGAGCTGAAAAGGAAAATTTTCAGATTAATAAAGAAGACGCCAATGATGGCTGAAGAGTTTTTCCCAGA
TTTACAAGCCACTGGAGACCCCTTTTTTCTGATACAATGCACGATTCTCTGCGCGCAAGGACCCTCGACTCACCCCCATGTTTCAGTGTC
ACAGAGACATTCTTTGATAAGGAAATGGCACAAACATAAAGGGAAAGGCTGCTAATTTTCTTTGGCAGATTGTATTGGCCAGCAGGAAAG
CAAGCTCTCCAGAGAATGCCCCCAGTTAAATACCTCCTCTACCTTTACCTAAGTTGCTCCTTTATTTTTATTTTATTATTATTATTATTA
TTATTATTATTTTTTGAGATGGAGTCTCACTTTGTAACCCAGGCTGGAATGCAATGGCATGATCTCAGCTCACTGCAACCTCCGCCTCCT
GGGTTCAAGCAAGTCTCCTGCCTCAGCCTCCGAGTAGCTGGGACTACAGGTGCACGCCACCACGCCTGGCTAATTTTTTGTATTTTAGTA
GAGACGGGGTTTCACCGTGTTGCCCAGGCTGGTCGCGAACTCCTGAGCTCAGGCAATCCGCCCACCTCAGCCTCCCAAAGTGTTGGGATT
ACAGGCATGAGCCACCATGCCCAGCTGCTCCTTTATTTTAATCCCTAAATATAATCCCTAAATATAGTTATATTTCATACTTAGTTTGTT
TTTAAAAAGTTTTCTCTGTAGAAAATTTTAATCATTCATACCCTTTACCTTTAGGTTTTTCTTTCTATACATTCAGTCAGGCACTGGGAT
CATCTGTTTACAGGCATTATATTTATTTGGCACTCCTGGAACAAGTATATCTAACCCATTCTTGATTTTTGGACTATTCAGGTGAACTAT
TTGAGGGGTATGGGGTCTAGAAGTTAAAAGATACGCATGTCTTCTGTTCTTTTCCCGTATCAATTCATTCCTTCATCTCTTTGCCAAGTT
GTTTTCCTTTCAGGGCCTGTCCTTCCAGTTTAGAACAGTACCATGAATCCCACTTGTGTCAATATTAAAGATAGCTGAGAAGCACCTTTC
AAATGGCACAGTCCCTCTTCAAGATGTCTAAAAGAATGGTTATGTCTGTCCAGTTAGGGATTTCACATCCACATGTAATCATGTCTGCTG
CTGTTGCTACCCAAATTTTCATTTCTCCACATTTTGGGTACTTAAGCTAAAACGTAATGGCCACAGTCTGTAATCCATTCACATTCCTCA
GTTTCACCACCTCCCTCTTCCAGACTGCACTCTCTGTCATCAGTCCCCTCCTTTCTAACAGAAATGGGGTTATGATTTTGAAGGCTGTGG
GTTCAGGGAGTCTTTGCCAATCCTGTTGGCCCTAAACTATCAAGGAGGCTCCATTTCACCATTTGATTTTTTGCATTTCAGGAGGCAACT
GATTGTTTCGATATGTACATATTACTCACGTATACCCCATTTCCTTCCAGTCAGCCCAACATTTTCCACCAGTCTGTCCCCATCTCTGAA
ATCCTTCCTTCTCTTTCCCCCTAAGTCTTTTGAGTGTCATCATGTACTGGTGGTTTCTCGGTTCCATCTCATCCATTTCCTTTTCAATGG
AGACTACAGCGTCAGCCAGCTCAGCCTTGGCTTTTAACTCAATATTCCAGTCCATAGGGGTGGTTAAAAGTTGCTGCAAGGCTGCAGGCA
CTGGCAGTGGGAAGAGGCAGACGACTAGATGACTTCTGCACTTTTAGCTGGTTGAAAAGTACCACTCCCACTCTGAACATCTGGCCGTCC
CTGCAAAGAGTGTACTGTGCTTGAAGCAGAGCACTCACACATAAATGGCTGTGTGTGGAATTGCTTGCCAAAGAAGTTTCTAGCCTTTCC
CTTTCCCCTAACTGCATCAGGGAAGAATTCTTATCTCTAGCTTGGTTTCCACATGAGGTTTTTCTGAGAAGGGCTTGGGACAAGAAGTCT
GTCATGTTAGTTAAGCAGGCAAGAAATCCTACTAATCCAGTTTTGTTTGAAAGTTGTTTGTCCGTATGATTTTTTAAAAGTCAAGTTTAA
TTTCAAAAAACCTTTTTTTTCTGAGATTACTTTTGGGGTAATATTTAAAATGAGAGACATTTTGTAACCCTGTAAAATACATAGGGAATA
TAACATTCCAGTGTATACAAAGAAGGCAAATTCTTTAATCAAATAAAGCGCATTATAAAATGA

>22949_22949_1_DIXDC1-ARCN1_DIXDC1_chr11_111808283_ENST00000440460_ARCN1_chr11_118463424_ENST00000359415_length(amino acids)=237AA_BP=1
MGCPAMLNSRLPLLFLASITGRHHSRVFRRLSCRYSPSISPITGAPTPDGSGMVITTSFSSKLSSCSSYSMLTSQPFPLSEGQQLIVSGI
KDSSVVCSLHFSTPTSLLTGNDFSGFFRPIRDSAVKSFLSTFGWVSLKPSCRTSSKFPRVRQASIVPAGGSPGGVSSPAAAAASSSSLCT
QRLSAQLIGIPPESRMPLTGNLDWSQTSGLHWACSHGGLRWRGPARSRFLWKQLGAH

--------------------------------------------------------------
>22949_22949_2_DIXDC1-ARCN1_DIXDC1_chr11_111808283_ENST00000440460_ARCN1_chr11_118463424_ENST00000392859_length(transcript)=1188nt_BP=357nt
TCCCGCAGGAAAGCGGGGCTGGGGGCAGCCCGGCAGCGCCGCTCAACCTAGTGCGCGCCCAGTTGTTTCCATAGGAACCGCGACCGCGCC
GGGCCCCTCCAGCGGAGGCCCCCGTGCGAGCATGCCCAGTGCAAGCCGCTAGTTTGGCTCCAGTCTAGGTTTCCAGTAAGTGGCATGCGG
GACTCCGGAGGGATCCCAATGAGCTGAGCCGAGAGCCTTTGTGTGCAGAGGGAGGAGGAGGAGGCGGCGGCGGCCGCCGGGCTGGAGACC
CCGCCCGGGGAGCCCCCAGCAGGAACAATGCTAGCCTGCCTGACCCGAGGGAACTTACTGGACGTCCTGCAGGAGGGCTTCAATGAGACC
CATCCAAATGTGGATAAAAAACTTTTCACTGCAGAGTCTCTAATTGGCCTGAAGAATCCAGAGAAGTCATTTCCAGTCAACAGTGACGTA
GGGGTGCTAAAGTGGAGACTACAAACCACAGAGGAATCTTTTATTCCACTGACAATTAATTGCTGGCCCTCGGAGAGTGGAAATGGCTGT
GATGTCAACATAGAATATGAGCTACAAGAAGATAATTTAGAACTGAATGATGTGGTTATCACCATCCCACTCCCGTCTGGTGTCGGCGCG
CCTGTTATCGGTGAGATCGATGGGGAGTATCGACATGACAGTCGACGAAATACCCTGGAGTGGTGCCTGCCTGTGATTGATGCCAAAAAT
AAGAGTGGCAGCCTGGAGTTTAGCATTGCTGGGCAGCCCAATGACTTCTTCCCTGTTCAAGTTTCCTTTGTCTCCAAGAAAAATTACTGT
AACATACAGGTTACCAAAGTGACCCAGGTAGATGGAAACAGCCCCGTCAGGTTTTCCACAGAGACCACTTTCCTAGTGGATAAGTATGAA
ATTCTGTAATACCAAGAAGAGGGAGCTGAAAAGGAAAATTTTCAGATTAATAAAGAAGACGCCAATGATGGCTGAAGAGTTTTTCCCAGA
TTTACAAGCCACTGGAGACCCCTTTTTTCTGATACAATGCACGATTCTCTGCGCGCAAGGACCCTCGACTCACCCCCATGTTTCAGTGTC
ACAGAGACATTCTTTGATAAGGAAATGGCACAAACATAAAGGGAAAGGCTGCTAATTTTCTTTGGCAGATTGTATTGGCCAGCAGGAAAG
CAAGCTCTCCAGAGAATG

>22949_22949_2_DIXDC1-ARCN1_DIXDC1_chr11_111808283_ENST00000440460_ARCN1_chr11_118463424_ENST00000392859_length(amino acids)=237AA_BP=1
MGCPAMLNSRLPLLFLASITGRHHSRVFRRLSCRYSPSISPITGAPTPDGSGMVITTSFSSKLSSCSSYSMLTSQPFPLSEGQQLIVSGI
KDSSVVCSLHFSTPTSLLTGNDFSGFFRPIRDSAVKSFLSTFGWVSLKPSCRTSSKFPRVRQASIVPAGGSPGGVSSPAAAAASSSSLCT
QRLSAQLIGIPPESRMPLTGNLDWSQTSGLHWACSHGGLRWRGPARSRFLWKQLGAH

--------------------------------------------------------------
>22949_22949_3_DIXDC1-ARCN1_DIXDC1_chr11_111808283_ENST00000531396_ARCN1_chr11_118463424_ENST00000359415_length(transcript)=2899nt_BP=133nt
GCAGAGGGAGGAGGAGGAGGCGGCGGCGGCCGCCGGGCTGGAGACCCCGCCCGGGGAGCCCCCAGCAGGAACAATGCTAGCCTGCCTGAC
CCGAGGGAACTTACTGGACGTCCTGCAGGAGGGCTTCAATGAGACCCATCCAAATGTGGATAAAAAACTTTTCACTGCAGAGTCTCTAAT
TGGCCTGAAGAATCCAGAGAAGTCATTTCCAGTCAACAGTGACGTAGGGGTGCTAAAGTGGAGACTACAAACCACAGAGGAATCTTTTAT
TCCACTGACAATTAATTGCTGGCCCTCGGAGAGTGGAAATGGCTGTGATGTCAACATAGAATATGAGCTACAAGAAGATAATTTAGAACT
GAATGATGTGGTTATCACCATCCCACTCCCGTCTGGTGTCGGCGCGCCTGTTATCGGTGAGATCGATGGGGAGTATCGACATGACAGTCG
ACGAAATACCCTGGAGTGGTGCCTGCCTGTGATTGATGCCAAAAATAAGAGTGGCAGCCTGGAGTTTAGCATTGCTGGGCAGCCCAATGA
CTTCTTCCCTGTTCAAGTTTCCTTTGTCTCCAAGAAAAATTACTGTAACATACAGGTTACCAAAGTGACCCAGGTAGATGGAAACAGCCC
CGTCAGGTTTTCCACAGAGACCACTTTCCTAGTGGATAAGTATGAAATTCTGTAATACCAAGAAGAGGGAGCTGAAAAGGAAAATTTTCA
GATTAATAAAGAAGACGCCAATGATGGCTGAAGAGTTTTTCCCAGATTTACAAGCCACTGGAGACCCCTTTTTTCTGATACAATGCACGA
TTCTCTGCGCGCAAGGACCCTCGACTCACCCCCATGTTTCAGTGTCACAGAGACATTCTTTGATAAGGAAATGGCACAAACATAAAGGGA
AAGGCTGCTAATTTTCTTTGGCAGATTGTATTGGCCAGCAGGAAAGCAAGCTCTCCAGAGAATGCCCCCAGTTAAATACCTCCTCTACCT
TTACCTAAGTTGCTCCTTTATTTTTATTTTATTATTATTATTATTATTATTATTATTTTTTGAGATGGAGTCTCACTTTGTAACCCAGGC
TGGAATGCAATGGCATGATCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCAAGTCTCCTGCCTCAGCCTCCGAGTAGCTGGGAC
TACAGGTGCACGCCACCACGCCTGGCTAATTTTTTGTATTTTAGTAGAGACGGGGTTTCACCGTGTTGCCCAGGCTGGTCGCGAACTCCT
GAGCTCAGGCAATCCGCCCACCTCAGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACCATGCCCAGCTGCTCCTTTATTTTAATCC
CTAAATATAATCCCTAAATATAGTTATATTTCATACTTAGTTTGTTTTTAAAAAGTTTTCTCTGTAGAAAATTTTAATCATTCATACCCT
TTACCTTTAGGTTTTTCTTTCTATACATTCAGTCAGGCACTGGGATCATCTGTTTACAGGCATTATATTTATTTGGCACTCCTGGAACAA
GTATATCTAACCCATTCTTGATTTTTGGACTATTCAGGTGAACTATTTGAGGGGTATGGGGTCTAGAAGTTAAAAGATACGCATGTCTTC
TGTTCTTTTCCCGTATCAATTCATTCCTTCATCTCTTTGCCAAGTTGTTTTCCTTTCAGGGCCTGTCCTTCCAGTTTAGAACAGTACCAT
GAATCCCACTTGTGTCAATATTAAAGATAGCTGAGAAGCACCTTTCAAATGGCACAGTCCCTCTTCAAGATGTCTAAAAGAATGGTTATG
TCTGTCCAGTTAGGGATTTCACATCCACATGTAATCATGTCTGCTGCTGTTGCTACCCAAATTTTCATTTCTCCACATTTTGGGTACTTA
AGCTAAAACGTAATGGCCACAGTCTGTAATCCATTCACATTCCTCAGTTTCACCACCTCCCTCTTCCAGACTGCACTCTCTGTCATCAGT
CCCCTCCTTTCTAACAGAAATGGGGTTATGATTTTGAAGGCTGTGGGTTCAGGGAGTCTTTGCCAATCCTGTTGGCCCTAAACTATCAAG
GAGGCTCCATTTCACCATTTGATTTTTTGCATTTCAGGAGGCAACTGATTGTTTCGATATGTACATATTACTCACGTATACCCCATTTCC
TTCCAGTCAGCCCAACATTTTCCACCAGTCTGTCCCCATCTCTGAAATCCTTCCTTCTCTTTCCCCCTAAGTCTTTTGAGTGTCATCATG
TACTGGTGGTTTCTCGGTTCCATCTCATCCATTTCCTTTTCAATGGAGACTACAGCGTCAGCCAGCTCAGCCTTGGCTTTTAACTCAATA
TTCCAGTCCATAGGGGTGGTTAAAAGTTGCTGCAAGGCTGCAGGCACTGGCAGTGGGAAGAGGCAGACGACTAGATGACTTCTGCACTTT
TAGCTGGTTGAAAAGTACCACTCCCACTCTGAACATCTGGCCGTCCCTGCAAAGAGTGTACTGTGCTTGAAGCAGAGCACTCACACATAA
ATGGCTGTGTGTGGAATTGCTTGCCAAAGAAGTTTCTAGCCTTTCCCTTTCCCCTAACTGCATCAGGGAAGAATTCTTATCTCTAGCTTG
GTTTCCACATGAGGTTTTTCTGAGAAGGGCTTGGGACAAGAAGTCTGTCATGTTAGTTAAGCAGGCAAGAAATCCTACTAATCCAGTTTT
GTTTGAAAGTTGTTTGTCCGTATGATTTTTTAAAAGTCAAGTTTAATTTCAAAAAACCTTTTTTTTCTGAGATTACTTTTGGGGTAATAT
TTAAAATGAGAGACATTTTGTAACCCTGTAAAATACATAGGGAATATAACATTCCAGTGTATACAAAGAAGGCAAATTCTTTAATCAAAT
AAAGCGCATTATAAAATGA

>22949_22949_3_DIXDC1-ARCN1_DIXDC1_chr11_111808283_ENST00000531396_ARCN1_chr11_118463424_ENST00000359415_length(amino acids)=215AA_BP=32
METPPGEPPAGTMLACLTRGNLLDVLQEGFNETHPNVDKKLFTAESLIGLKNPEKSFPVNSDVGVLKWRLQTTEESFIPLTINCWPSESG
NGCDVNIEYELQEDNLELNDVVITIPLPSGVGAPVIGEIDGEYRHDSRRNTLEWCLPVIDAKNKSGSLEFSIAGQPNDFFPVQVSFVSKK
NYCNIQVTKVTQVDGNSPVRFSTETTFLVDKYEIL

--------------------------------------------------------------
>22949_22949_4_DIXDC1-ARCN1_DIXDC1_chr11_111808283_ENST00000531396_ARCN1_chr11_118463424_ENST00000392859_length(transcript)=964nt_BP=133nt
GCAGAGGGAGGAGGAGGAGGCGGCGGCGGCCGCCGGGCTGGAGACCCCGCCCGGGGAGCCCCCAGCAGGAACAATGCTAGCCTGCCTGAC
CCGAGGGAACTTACTGGACGTCCTGCAGGAGGGCTTCAATGAGACCCATCCAAATGTGGATAAAAAACTTTTCACTGCAGAGTCTCTAAT
TGGCCTGAAGAATCCAGAGAAGTCATTTCCAGTCAACAGTGACGTAGGGGTGCTAAAGTGGAGACTACAAACCACAGAGGAATCTTTTAT
TCCACTGACAATTAATTGCTGGCCCTCGGAGAGTGGAAATGGCTGTGATGTCAACATAGAATATGAGCTACAAGAAGATAATTTAGAACT
GAATGATGTGGTTATCACCATCCCACTCCCGTCTGGTGTCGGCGCGCCTGTTATCGGTGAGATCGATGGGGAGTATCGACATGACAGTCG
ACGAAATACCCTGGAGTGGTGCCTGCCTGTGATTGATGCCAAAAATAAGAGTGGCAGCCTGGAGTTTAGCATTGCTGGGCAGCCCAATGA
CTTCTTCCCTGTTCAAGTTTCCTTTGTCTCCAAGAAAAATTACTGTAACATACAGGTTACCAAAGTGACCCAGGTAGATGGAAACAGCCC
CGTCAGGTTTTCCACAGAGACCACTTTCCTAGTGGATAAGTATGAAATTCTGTAATACCAAGAAGAGGGAGCTGAAAAGGAAAATTTTCA
GATTAATAAAGAAGACGCCAATGATGGCTGAAGAGTTTTTCCCAGATTTACAAGCCACTGGAGACCCCTTTTTTCTGATACAATGCACGA
TTCTCTGCGCGCAAGGACCCTCGACTCACCCCCATGTTTCAGTGTCACAGAGACATTCTTTGATAAGGAAATGGCACAAACATAAAGGGA
AAGGCTGCTAATTTTCTTTGGCAGATTGTATTGGCCAGCAGGAAAGCAAGCTCTCCAGAGAATG

>22949_22949_4_DIXDC1-ARCN1_DIXDC1_chr11_111808283_ENST00000531396_ARCN1_chr11_118463424_ENST00000392859_length(amino acids)=215AA_BP=32
METPPGEPPAGTMLACLTRGNLLDVLQEGFNETHPNVDKKLFTAESLIGLKNPEKSFPVNSDVGVLKWRLQTTEESFIPLTINCWPSESG
NGCDVNIEYELQEDNLELNDVVITIPLPSGVGAPVIGEIDGEYRHDSRRNTLEWCLPVIDAKNKSGSLEFSIAGQPNDFFPVQVSFVSKK
NYCNIQVTKVTQVDGNSPVRFSTETTFLVDKYEIL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DIXDC1-ARCN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DIXDC1-ARCN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DIXDC1-ARCN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDIXDC1C0003469Anxiety Disorders1CTD_human
HgeneDIXDC1C0004352Autistic Disorder1CTD_human
HgeneDIXDC1C0005586Bipolar Disorder1CTD_human
HgeneDIXDC1C0005587Depression, Bipolar1CTD_human
HgeneDIXDC1C0011573Endogenous depression1CTD_human
HgeneDIXDC1C0011581Depressive disorder1CTD_human
HgeneDIXDC1C0024713Manic Disorder1CTD_human
HgeneDIXDC1C0025193Melancholia1CTD_human
HgeneDIXDC1C0036341Schizophrenia1CTD_human
HgeneDIXDC1C0041696Unipolar Depression1CTD_human
HgeneDIXDC1C0086133Depressive Syndrome1CTD_human
HgeneDIXDC1C0282126Depression, Neurotic1CTD_human
HgeneDIXDC1C0338831Manic1CTD_human
HgeneDIXDC1C0376280Anxiety States, Neurotic1CTD_human
HgeneDIXDC1C1279420Anxiety neurosis (finding)1CTD_human
TgeneC0004134Ataxia1CTD_human
TgeneC0240991Ataxia, Sensory1CTD_human
TgeneC0278161Ataxia, Motor1CTD_human
TgeneC0427190Ataxia, Truncal1CTD_human
TgeneC0520966Abnormal coordination1CTD_human
TgeneC0750937Ataxia, Appendicular1CTD_human
TgeneC0750940Tremor, Rubral1CTD_human
TgeneC4310686SHORT STATURE, RHIZOMELIC, WITH MICROCEPHALY, MICROGNATHIA, AND DEVELOPMENTAL DELAY1GENOMICS_ENGLAND