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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CBFB-PLEKHG4 (FusionGDB2 ID:HG865TG25894) |
Fusion Gene Summary for CBFB-PLEKHG4 |
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Fusion gene information | Fusion gene name: CBFB-PLEKHG4 | Fusion gene ID: hg865tg25894 | Hgene | Tgene | Gene symbol | CBFB | PLEKHG4 | Gene ID | 865 | 25894 |
Gene name | core-binding factor subunit beta | pleckstrin homology and RhoGEF domain containing G4 | |
Synonyms | PEBP2B | ARHGEF44|PRTPHN1|SCA4 | |
Cytomap | ('CBFB')('PLEKHG4') 16q22.1 | 16q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | core-binding factor subunit betaCBF-betaPEA2-betaPEBP2-betaSL3-3 enhancer factor 1 beta subunitSL3-3 enhancer factor 1 subunit betaSL3/AKV core-binding factor beta subunitcore-binding factor beta subunitpolyomavirus enhancer binding protein 2, bet | puratrophin-1PH domain-containing family G member 4Purkinje cell atrophy associated protein 1pleckstrin homology domain containing, family G (with RhoGef domain) member 4 | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | Q13951 | . | |
Ensembl transtripts involved in fusion gene | ENST00000290858, ENST00000412916, ENST00000561924, ENST00000568858, | ||
Fusion gene scores | * DoF score | 17 X 18 X 12=3672 | 2 X 4 X 2=16 |
# samples | 33 | 2 | |
** MAII score | log2(33/3672*10)=-3.47602812916799 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/16*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CBFB [Title/Abstract] AND PLEKHG4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CBFB(67116211)-PLEKHG4(67312644), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | CBFB-PLEKHG4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CBFB-PLEKHG4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CBFB-PLEKHG4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. CBFB-PLEKHG4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | OV | TCGA-13-1407-01A | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
ChimerDB4 | OV | TCGA-13-1407-01A | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
ChimerDB4 | OV | TCGA-13-1407-01A | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
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Fusion Gene ORF analysis for CBFB-PLEKHG4 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000290858 | ENST00000360461 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
5CDS-5UTR | ENST00000290858 | ENST00000360461 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
5CDS-5UTR | ENST00000412916 | ENST00000360461 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
5CDS-5UTR | ENST00000412916 | ENST00000360461 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
5CDS-5UTR | ENST00000561924 | ENST00000360461 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
5CDS-5UTR | ENST00000561924 | ENST00000360461 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
5CDS-intron | ENST00000290858 | ENST00000379344 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
5CDS-intron | ENST00000290858 | ENST00000379344 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
5CDS-intron | ENST00000290858 | ENST00000427155 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
5CDS-intron | ENST00000290858 | ENST00000427155 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
5CDS-intron | ENST00000290858 | ENST00000450733 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
5CDS-intron | ENST00000290858 | ENST00000450733 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
5CDS-intron | ENST00000412916 | ENST00000379344 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
5CDS-intron | ENST00000412916 | ENST00000379344 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
5CDS-intron | ENST00000412916 | ENST00000427155 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
5CDS-intron | ENST00000412916 | ENST00000427155 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
5CDS-intron | ENST00000412916 | ENST00000450733 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
5CDS-intron | ENST00000412916 | ENST00000450733 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
5CDS-intron | ENST00000561924 | ENST00000379344 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
5CDS-intron | ENST00000561924 | ENST00000379344 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
5CDS-intron | ENST00000561924 | ENST00000427155 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
5CDS-intron | ENST00000561924 | ENST00000427155 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
5CDS-intron | ENST00000561924 | ENST00000450733 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
5CDS-intron | ENST00000561924 | ENST00000450733 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
Frame-shift | ENST00000290858 | ENST00000360461 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
Frame-shift | ENST00000290858 | ENST00000379344 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
Frame-shift | ENST00000290858 | ENST00000427155 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
Frame-shift | ENST00000290858 | ENST00000450733 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
Frame-shift | ENST00000412916 | ENST00000379344 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
Frame-shift | ENST00000412916 | ENST00000427155 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
Frame-shift | ENST00000561924 | ENST00000360461 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
Frame-shift | ENST00000561924 | ENST00000379344 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
Frame-shift | ENST00000561924 | ENST00000427155 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
Frame-shift | ENST00000561924 | ENST00000450733 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
In-frame | ENST00000412916 | ENST00000360461 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
In-frame | ENST00000412916 | ENST00000450733 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
intron-3CDS | ENST00000568858 | ENST00000360461 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
intron-3CDS | ENST00000568858 | ENST00000379344 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
intron-3CDS | ENST00000568858 | ENST00000427155 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
intron-3CDS | ENST00000568858 | ENST00000450733 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + |
intron-5UTR | ENST00000568858 | ENST00000360461 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
intron-5UTR | ENST00000568858 | ENST00000360461 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
intron-intron | ENST00000568858 | ENST00000379344 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
intron-intron | ENST00000568858 | ENST00000379344 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
intron-intron | ENST00000568858 | ENST00000427155 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
intron-intron | ENST00000568858 | ENST00000427155 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
intron-intron | ENST00000568858 | ENST00000450733 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67311680 | + |
intron-intron | ENST00000568858 | ENST00000450733 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67312644 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000412916 | CBFB | chr16 | 67116211 | + | ENST00000360461 | PLEKHG4 | chr16 | 67314028 | + | 4824 | 658 | 163 | 4152 | 1329 |
ENST00000412916 | CBFB | chr16 | 67116211 | + | ENST00000450733 | PLEKHG4 | chr16 | 67314028 | + | 4601 | 658 | 163 | 3909 | 1248 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000412916 | ENST00000360461 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + | 0.005288378 | 0.99471164 |
ENST00000412916 | ENST00000450733 | CBFB | chr16 | 67116211 | + | PLEKHG4 | chr16 | 67314028 | + | 0.005479475 | 0.99452055 |
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Fusion Genomic Features for CBFB-PLEKHG4 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CBFB-PLEKHG4 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:67116211/chr16:67312644) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CBFB | . |
FUNCTION: Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. {ECO:0000250|UniProtKB:Q08024}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | PLEKHG4 | chr16:67116211 | chr16:67314028 | ENST00000360461 | 0 | 21 | 732_908 | 0 | 1192.0 | Domain | DH | |
Tgene | PLEKHG4 | chr16:67116211 | chr16:67314028 | ENST00000360461 | 0 | 21 | 920_1027 | 0 | 1192.0 | Domain | PH | |
Tgene | PLEKHG4 | chr16:67116211 | chr16:67314028 | ENST00000379344 | 0 | 22 | 732_908 | 0 | 1192.0 | Domain | DH | |
Tgene | PLEKHG4 | chr16:67116211 | chr16:67314028 | ENST00000379344 | 0 | 22 | 920_1027 | 0 | 1192.0 | Domain | PH | |
Tgene | PLEKHG4 | chr16:67116211 | chr16:67314028 | ENST00000427155 | 0 | 22 | 732_908 | 0 | 1192.0 | Domain | DH | |
Tgene | PLEKHG4 | chr16:67116211 | chr16:67314028 | ENST00000427155 | 0 | 22 | 920_1027 | 0 | 1192.0 | Domain | PH | |
Tgene | PLEKHG4 | chr16:67116211 | chr16:67314028 | ENST00000450733 | 0 | 20 | 732_908 | 0 | 1111.0 | Domain | DH | |
Tgene | PLEKHG4 | chr16:67116211 | chr16:67314028 | ENST00000450733 | 0 | 20 | 920_1027 | 0 | 1111.0 | Domain | PH |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CBFB-PLEKHG4 |
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>13376_13376_1_CBFB-PLEKHG4_CBFB_chr16_67116211_ENST00000412916_PLEKHG4_chr16_67314028_ENST00000360461_length(transcript)=4824nt_BP=658nt AGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTCAGTCGGTC AGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGCGTCGTGCC CGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGGGACCGGCC CCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAATCTGTCTCT CCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGCAAGGTATA TTTGAAGGCTCCCATGATTCTGAATGGAGTCTGTGTTATCTGGAAAGGCTGGATTGATCTCCAAAGACTGGATGGTATGGGCTGTCTGGA GTTTGATGAGGAGCGAGCCCAGCAGGAGGATGCATTAGCACAACAGGCCTTTGAAGAGGCTCGGAGAAGGACACGCGAATTTGAAGATAG AGACAGGTCTCATCGGGAGGAAATGGAGTTCAGGGATGCCTGGGAAGAGGAGGAACCTGCTTCCCAGATGCACGTTAAGGACCCAGGTCC TCCAAGACCACCAGCCGGGGCCACCCAGGATGAGGAGCTACAGGGCAGCCCCTTGTCCAGGAAATTCCAGTTACCCCCAGCTGCAGATGA GTCGGGGGATGCCCAGAGGGGCACAGTAGAAAGCTCCTCAGTCCTGTCAGAAGGGCCAGGCCCCTCTGGAGTGGAGAGTCTCCTATGCCC CATGTCCTCCCACCTCAGCTTGGCACAGGGTGAGAGTGACACCCCAGGGGTAGGGTTGGTAGGGGACCCAGGTCCAAGCAGGGCGATGCC ATCTGGCTTGAGCCCTGGGGCATTGGACAGCGACCCTGTGGGCCTTGGAGACCCTTTATCAGAAATATCAAAGCTGCTGGAGGCAGCCCC CAGTGGATCCGGCCTCCCTAAGCCTGCTGACTGCCTCCTGGCCCAAGACCTCTGTTGGGAGCTGCTGGCCAGTGGTATGGCCACCTTGCC AGGGACTCGGGATGTCCAAGGCCGGGCAGTGCTGCTTCTGTGTGCCCACAGCCCAGCCTGGCTTCAGTCTGAGTGCAGCAGCCAGGAACT CATCCGCCTCCTGCTGTACCTGCGAAGCATCCCCAGGCCCGAAGTACAGGCACTGGGACTGACAGTGCTAGTTGATGCCCGAATTTGTGC TCCAAGTTCTTCCCTCTTCTCTGGGCTCAGCCAACTACAAGAAGCAGCCCCAGGGGCCGTGTACCAGGTGCTGCTAGTGGGAAGCACGCT GCTGAAGGAAGTGCCTTCCGGGCTGCAGCTGGAGCAGTTGCCTTCTCAGAGCCTGCTGACCCACATCCCAACGGCGGGGCTGCCCACTTC GCTAGGAGGAGGCCTGCCTTACTGCCACCAGGCCTGGCTGGATTTCCGAAGGCGGCTGGAAGCTCTACTACAGAACTGCCAGGCAGCTTG TGCCCTGCTCCAGGGGGCCATCGAAAGTGTGAAGGCTGTGCCCCAGCCCATGGAGCCTGGGGAGGTCGGTCAGCTGCTACAGCAGACAGA GGTCCTGATGCAGCAGGTGCTAGACTCGCCATGGCTGGCATGGCTACAATGCCAGGGGGGCCGGGAGCTGACATGGCTGAAGCAAGAGGT CCCAGAGGTGACCCTGAGCCCAGACTACAGGACGGCAATGGACAAGGCTGACGAGCTATATGACCGGGTGGATGGATTGCTGCACCAACT GACCCTGCAGAGCAACCAGCGAATACAGGCCCTAGAGTTGGTCCAAACACTGGAGGCCCGGGAAAGCGGACTGCACCAGATTGAAGTGTG GCTGCAGCAGGTGGGCTGGCCAGCACTGGAGGAGGCTGGGGAGCCCTCGCTGGACATGCTGCTCCAGGCCCAAGGCTCTTTTCAGGAGCT GTACCAGGTTGCCCAGGAGCAGGTCAGGCAAGGGGAGAAGTTTCTGCAGCCGCTGACTGGCTGGGAGGCGGCTGAACTGGACCCCCCTGG GGCACGCTTTCTGGCCCTGCGAGCCCAGCTGACTGAATTCTCTAGGGCTTTGGCCCAGCGGTGCCAGCGGCTGGCGGATGCTGAGAGGCT GTTTCAGCTCTTCAGGGAGGCCTTGACGTGGGCTGAGGAGGGGCAGCGAGTGTTGGCAGAGCTGGAGCAGGAACGCCCGGGGGTTGTGTT GCAGCAGCTGCAGCTGCACTGGACCAGGCACCCTGACTTGCCTCCTGCCCACTTCCGAAAGATGTGGGCTCTGGCCACGGGGCTGGGCTC AGAGGCCATCCGCCAGGAGTGCCGCTGGGCCTGGGCGCGGTGCCAGGACACCTGGCTGGCCCTGGACCAAAAGCTTGAGGCTTCACTGAA GCTACCACCGGTGGGCAGCACAGCTAGCCTGTGTGTCAGCCAGGTCCCCGCTGCACCTGCCCACCCTCCCCTGAGGAAGGCCTACAGCTT CGATCGGAATCTGGGGCAGAGTCTCAGTGAACCTGCCTGCCACTGCCACCATGCGGCCACTATTGCTGCCTGCCGCAGACCAGAGGCTGG AGGAGGTGCCCTGCCCCAGGCATCCCCTACTGTGCCTCCACCAGGCAGCTCTGACCCCAGGAGCCTCAACAGGCTACAGCTGGTGCTGGC AGAGATGGTGGCCACGGAGCGGGAGTATGTCCGGGCTCTAGAGTACACTATGGAGAACTATTTCCCCGAGCTGGATCGCCCCGATGTGCC CCAGGGCCTCCGCGGTCAGCGTGCCCACCTCTTTGGCAACCTGGAGAAGCTGCGGGACTTCCACTGCCACTTCTTCCTGCGTGAGCTGGA GGCTTGCACCCGGCACCCACCACGAGTGGCCTATGCCTTCCTGCGCCATAGGGTGCAGTTTGGGATGTACGCGCTCTACAGCAAGAATAA GCCTCGCTCCGATGCCCTGATGTCAAGCTATGGGCACACCTTCTTCAAGGACAAGCAGCAAGCACTGGGGGACCACCTGGACCTGGCCTC CTACCTGCTAAAGCCCATCCAGCGCATGGGCAAGTACGCACTGCTGCTGCAGGAGCTGGCACGGGCCTGCGGGGGCCCCACGCAGGAGCT CAGTGCGCTGCGGGAGGCCCAGAGCCTTGTGCACTTCCAGCTGCGGCACGGAAACGACCTGCTGGCCATGGACGCCATCCAGGGCTGTGA TGTTAACCTCAAGGAACAGGGGCAGCTGGTGCGACAGGATGAGTTTGTGGTGCGCACTGGGCGCCACAAGTCCGTGCGCCGCATCTTCCT TTTTGAGGAGCTGCTGCTCTTCAGCAAGCCTCGCCATGGGCCCACAGGGGTTGACACATTTGCCTACAAGCGCTCCTTCAAGATGGCAGA CCTTGGTCTCACTGAGTGCTGTGGGAACAGCAACCTGCGCTTCGAGATCTGGTTCCGCCGCCGCAAGGCCAGGGACACCTTTGTGCTGCA GGCCTCCAGCCTGGCTATCAAGCAGGCCTGGACAGCTGACATCTCCCACCTGCTTTGGAGGCAGGCCGTCCACAACAAGGAGGTGCGCAT GGCTGAGATGGTGTCCATGGGTGTGGGGAACAAGGCCTTCCGAGACATTGCTCCCAGCGAGGAAGCCATCAACGACCGCACCGTCAACTA TGTCCTGAAGTGCCGAGAAGTTCGCTCTCGGGCGTCCATTGCCGTAGCCCCGTTTGACCATGACAGCCTCTACCTGGGGGCCTCGAACTC CCTTCCTGGAGACCCTGCCTCTTGCTCTGTTCTGGGGTCCCTCAACCTGCACCTGTACAGAGACCCAGCTCTTCTGGGTCTCCGCTGTCC CCTGTATCCCAGCTTCCCAGAGGAAGCAGCACTGGAGGCTGAGGCAGAGCTGGGCGGCCAGCCCTCTTTGACTGCTGAGGACTCAGAGAT CTCGTCCCAATGCCCATCAGCCAGTGGCTCCAGTGGCTCTGACAGCAGCTGTGTGTCAGGGCAGGCCCTGGGTAGGGGCCTGGAGGACTT ACCCTGTGTCTGAGCCCGGGACTGGACGAGCAGTAGATCCAGCAGCCTGCAGCTCCAAGGAACATTGCCTCTCTGGATCTGCTGTGACCA GGGTGTGGCTGACACCTGGGCTACCTCCAACCTACATGTGCAACGCTGTTGACTACCCTTTCTGATGTGTGTGGCCATTGGACTAACTGG CACGGGGCCTCTCTAGGGAAGTCTGGTTGTAGAGCCTGAATAGGCTCCTGGCCCCATGACCCCTTCTCCTGTCCCCAGCTCCCATCCCAG TTGTGGGTTAAGAATAGGCTAGAGCAGACATTGGGTGTTTCCATGCTGTAGGCTGGTGGGGGACCATGTGCCTCTAGGCAGTGACTAGGG TGCCCCCACCCCTCAGGAAGAACACAGGTGGGCTCCTAGCAGCTGATCCCCAATGCCTGGCCTTAAAGCCGAGCTCAGTTACCATAGGGA CAGGTCCACCTCTACTGGGCCCTCATGCTTGCCTTTCCTGGCCCCCAGGCCCAGCCCCTTTTTACTGGGGCAGTTTCGTTATTTTGACTT GATGCCTTTTGAATAACTTTCAATAGAATTGTCTAAAATTATCTTACTGGTTGTTAGGCCTTTGGTGTCTCAGAGAAGGAGTCTAGGTCT >13376_13376_1_CBFB-PLEKHG4_CBFB_chr16_67116211_ENST00000412916_PLEKHG4_chr16_67314028_ENST00000360461_length(amino acids)=1329AA_BP=0 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEFRDAWEEEEPASQMH VKDPGPPRPPAGATQDEELQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGESDTPGVGLVGDPG PSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSE CSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPSQSLLTHIPT AGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELT WLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQ GSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQE RPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCVSQVPAAPAHPPL RKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPEL DRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQALGD HLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKS VRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAVH NKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPAL -------------------------------------------------------------- >13376_13376_2_CBFB-PLEKHG4_CBFB_chr16_67116211_ENST00000412916_PLEKHG4_chr16_67314028_ENST00000450733_length(transcript)=4601nt_BP=658nt AGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTCAGTCGGTC AGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGCGTCGTGCC CGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGGGACCGGCC CCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAATCTGTCTCT CCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGCAAGGTATA TTTGAAGGCTCCCATGATTCTGAATGGAGTCTGTGTTATCTGGAAAGGCTGGATTGATCTCCAAAGACTGGATGGTATGGGCTGTCTGGA GTTTGATGAGGAGCGAGCCCAGCAGGAGGATGCATTAGCACAACAGGCCTTTGAAGAGGCTCGGAGAAGGACACGCGAATTTGAAGATAG AGACAGGTCTCATCGGGAGGAAATGGAGTTCAGGGATGCCTGGGAAGAGGAGGAACCTGCTTCCCAGATGCACGTTAAGGACCCAGGTCC TCCAAGACCACCAGCCGGGGCCACCCAGGATGAGGAGCTACAGGGCAGCCCCTTGTCCAGGAAATTCCAGTTACCCCCAGCTGCAGATGA GTCGGGGGATGCCCAGAGGGGCACAGTAGAAAGCTCCTCAGTCCTGTCAGAAGGGCCAGGCCCCTCTGGAGTGGAGAGTCTCCTATGCCC CATGTCCTCCCACCTCAGCTTGGCACAGGGGACTCGGGATGTCCAAGGCCGGGCAGTGCTGCTTCTGTGTGCCCACAGCCCAGCCTGGCT TCAGTCTGAGTGCAGCAGCCAGGAACTCATCCGCCTCCTGCTGTACCTGCGAAGCATCCCCAGGCCCGAAGTACAGGCACTGGGACTGAC AGTGCTAGTTGATGCCCGAATTTGTGCTCCAAGTTCTTCCCTCTTCTCTGGGCTCAGCCAACTACAAGAAGCAGCCCCAGGGGCCGTGTA CCAGGTGCTGCTAGTGGGAAGCACGCTGCTGAAGGAAGTGCCTTCCGGGCTGCAGCTGGAGCAGTTGCCTTCTCAGAGCCTGCTGACCCA CATCCCAACGGCGGGGCTGCCCACTTCGCTAGGAGGAGGCCTGCCTTACTGCCACCAGGCCTGGCTGGATTTCCGAAGGCGGCTGGAAGC TCTACTACAGAACTGCCAGGCAGCTTGTGCCCTGCTCCAGGGGGCCATCGAAAGTGTGAAGGCTGTGCCCCAGCCCATGGAGCCTGGGGA GGTCGGTCAGCTGCTACAGCAGACAGAGGTCCTGATGCAGCAGGTGCTAGACTCGCCATGGCTGGCATGGCTACAATGCCAGGGGGGCCG GGAGCTGACATGGCTGAAGCAAGAGGTCCCAGAGGTGACCCTGAGCCCAGACTACAGGACGGCAATGGACAAGGCTGACGAGCTATATGA CCGGGTGGATGGATTGCTGCACCAACTGACCCTGCAGAGCAACCAGCGAATACAGGCCCTAGAGTTGGTCCAAACACTGGAGGCCCGGGA AAGCGGACTGCACCAGATTGAAGTGTGGCTGCAGCAGGTGGGCTGGCCAGCACTGGAGGAGGCTGGGGAGCCCTCGCTGGACATGCTGCT CCAGGCCCAAGGCTCTTTTCAGGAGCTGTACCAGGTTGCCCAGGAGCAGGTCAGGCAAGGGGAGAAGTTTCTGCAGCCGCTGACTGGCTG GGAGGCGGCTGAACTGGACCCCCCTGGGGCACGCTTTCTGGCCCTGCGAGCCCAGCTGACTGAATTCTCTAGGGCTTTGGCCCAGCGGTG CCAGCGGCTGGCGGATGCTGAGAGGCTGTTTCAGCTCTTCAGGGAGGCCTTGACGTGGGCTGAGGAGGGGCAGCGAGTGTTGGCAGAGCT GGAGCAGGAACGCCCGGGGGTTGTGTTGCAGCAGCTGCAGCTGCACTGGACCAGGCACCCTGACTTGCCTCCTGCCCACTTCCGAAAGAT GTGGGCTCTGGCCACGGGGCTGGGCTCAGAGGCCATCCGCCAGGAGTGCCGCTGGGCCTGGGCGCGGTGCCAGGACACCTGGCTGGCCCT GGACCAAAAGCTTGAGGCTTCACTGAAGCTACCACCGGTGGGCAGCACAGCTAGCCTGTGTGTCAGCCAGGTCCCCGCTGCACCTGCCCA CCCTCCCCTGAGGAAGGCCTACAGCTTCGATCGGAATCTGGGGCAGAGTCTCAGTGAACCTGCCTGCCACTGCCACCATGCGGCCACTAT TGCTGCCTGCCGCAGACCAGAGGCTGGAGGAGGTGCCCTGCCCCAGGCATCCCCTACTGTGCCTCCACCAGGCAGCTCTGACCCCAGGAG CCTCAACAGGCTACAGCTGGTGCTGGCAGAGATGGTGGCCACGGAGCGGGAGTATGTCCGGGCTCTAGAGTACACTATGGAGAACTATTT CCCCGAGCTGGATCGCCCCGATGTGCCCCAGGGCCTCCGCGGTCAGCGTGCCCACCTCTTTGGCAACCTGGAGAAGCTGCGGGACTTCCA CTGCCACTTCTTCCTGCGTGAGCTGGAGGCTTGCACCCGGCACCCACCACGAGTGGCCTATGCCTTCCTGCGCCATAGGGTGCAGTTTGG GATGTACGCGCTCTACAGCAAGAATAAGCCTCGCTCCGATGCCCTGATGTCAAGCTATGGGCACACCTTCTTCAAGGACAAGCAGCAAGC ACTGGGGGACCACCTGGACCTGGCCTCCTACCTGCTAAAGCCCATCCAGCGCATGGGCAAGTACGCACTGCTGCTGCAGGAGCTGGCACG GGCCTGCGGGGGCCCCACGCAGGAGCTCAGTGCGCTGCGGGAGGCCCAGAGCCTTGTGCACTTCCAGCTGCGGCACGGAAACGACCTGCT GGCCATGGACGCCATCCAGGGCTGTGATGTTAACCTCAAGGAACAGGGGCAGCTGGTGCGACAGGATGAGTTTGTGGTGCGCACTGGGCG CCACAAGTCCGTGCGCCGCATCTTCCTTTTTGAGGAGCTGCTGCTCTTCAGCAAGCCTCGCCATGGGCCCACAGGGGTTGACACATTTGC CTACAAGCGCTCCTTCAAGATGGCAGACCTTGGTCTCACTGAGTGCTGTGGGAACAGCAACCTGCGCTTCGAGATCTGGTTCCGCCGCCG CAAGGCCAGGGACACCTTTGTGCTGCAGGCCTCCAGCCTGGCTATCAAGCAGGCCTGGACAGCTGACATCTCCCACCTGCTTTGGAGGCA GGCCGTCCACAACAAGGAGGTGCGCATGGCTGAGATGGTGTCCATGGGTGTGGGGAACAAGGCCTTCCGAGACATTGCTCCCAGCGAGGA AGCCATCAACGACCGCACCGTCAACTATGTCCTGAAGTGCCGAGAAGTTCGCTCTCGGGCGTCCATTGCCGTAGCCCCGTTTGACCATGA CAGCCTCTACCTGGGGGCCTCGAACTCCCTTCCTGGAGACCCTGCCTCTTGCTCTGTTCTGGGGTCCCTCAACCTGCACCTGTACAGAGA CCCAGCTCTTCTGGGTCTCCGCTGTCCCCTGTATCCCAGCTTCCCAGAGGAAGCAGCACTGGAGGCTGAGGCAGAGCTGGGCGGCCAGCC CTCTTTGACTGCTGAGGACTCAGAGATCTCGTCCCAATGCCCATCAGCCAGTGGCTCCAGTGGCTCTGACAGCAGCTGTGTGTCAGGGCA GGCCCTGGGTAGGGGCCTGGAGGACTTACCCTGTGTCTGAGCCCGGGACTGGACGAGCAGTAGATCCAGCAGCCTGCAGCTCCAAGGAAC ATTGCCTCTCTGGATCTGCTGTGACCAGGGTGTGGCTGACACCTGGGCTACCTCCAACCTACATGTGCAACGCTGTTGACTACCCTTTCT GATGTGTGTGGCCATTGGACTAACTGGCACGGGGCCTCTCTAGGGAAGTCTGGTTGTAGAGCCTGAATAGGCTCCTGGCCCCATGACCCC TTCTCCTGTCCCCAGCTCCCATCCCAGTTGTGGGTTAAGAATAGGCTAGAGCAGACATTGGGTGTTTCCATGCTGTAGGCTGGTGGGGGA CCATGTGCCTCTAGGCAGTGACTAGGGTGCCCCCACCCCTCAGGAAGAACACAGGTGGGCTCCTAGCAGCTGATCCCCAATGCCTGGCCT TAAAGCCGAGCTCAGTTACCATAGGGACAGGTCCACCTCTACTGGGCCCTCATGCTTGCCTTTCCTGGCCCCCAGGCCCAGCCCCTTTTT ACTGGGGCAGTTTCGTTATTTTGACTTGATGCCTTTTGAATAACTTTCAATAGAATTGTCTAAAATTATCTTACTGGTTGTTAGGCCTTT GGTGTCTCAGAGAAGGAGTCTAGGTCTTTGATGTGTGATTTAATCTTTTATTTGTTTATAATAAAAAATAGACTGATATGTACCCTCTGA >13376_13376_2_CBFB-PLEKHG4_CBFB_chr16_67116211_ENST00000412916_PLEKHG4_chr16_67314028_ENST00000450733_length(amino acids)=1248AA_BP=0 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEFRDAWEEEEPASQMH VKDPGPPRPPAGATQDEELQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGTRDVQGRAVLLLCA HSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPS QSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWL QCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEP SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQ RVLAELEQERPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCVSQV PAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEY TMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFF KDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEF VVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADIS HLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSLYLGASNSLPGDPASCSVLGSLN -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CBFB-PLEKHG4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CBFB-PLEKHG4 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CBFB-PLEKHG4 |
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Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CBFB | C0023467 | Leukemia, Myelocytic, Acute | 2 | CTD_human |
Hgene | CBFB | C0023479 | Acute myelomonocytic leukemia | 2 | CTD_human;ORPHANET |
Hgene | CBFB | C0026998 | Acute Myeloid Leukemia, M1 | 2 | CTD_human |
Hgene | CBFB | C1879321 | Acute Myeloid Leukemia (AML-M2) | 2 | CTD_human |
Hgene | CBFB | C0005941 | Bone Diseases, Developmental | 1 | CTD_human |
Hgene | CBFB | C0008925 | Cleft Palate | 1 | CTD_human |
Hgene | CBFB | C0018798 | Congenital Heart Defects | 1 | CTD_human |
Hgene | CBFB | C0029396 | Heterotopic Ossification | 1 | CTD_human |
Hgene | CBFB | C1837218 | Cleft palate, isolated | 1 | CTD_human |
Tgene | C0752122 | Spinocerebellar Ataxia Type 4 | 2 | ORPHANET |