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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:B4GALT4-ACSL5 (FusionGDB2 ID:HG8702TG51703)

Fusion Gene Summary for B4GALT4-ACSL5

check button Fusion gene summary
Fusion gene informationFusion gene name: B4GALT4-ACSL5
Fusion gene ID: hg8702tg51703
HgeneTgene
Gene symbol

B4GALT4

ACSL5

Gene ID

8702

51703

Gene namebeta-1,4-galactosyltransferase 4acyl-CoA synthetase long chain family member 5
SynonymsB4Gal-T4|beta4Gal-T4ACS2|ACS5|FACL5
Cytomap('B4GALT4')('ACSL5')

3q13.32

10q25.2

Type of geneprotein-codingprotein-coding
Descriptionbeta-1,4-galactosyltransferase 4N-acetyllactosamine synthaseUDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 4UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4UDP-galactose:beta-N-long-chain-fatty-acid--CoA ligase 5FACL5 for fatty acid coenzyme A ligase 5LACS 5arachidonate--CoA ligasefatty acid coenzyme A ligase 5fatty-acid-Coenzyme A ligase, long-chain 5long-chain acyl-CoA synthetase 5long-chain fatty acid coenzyme A ligase
Modification date2020031320200313
UniProtAcc.

Q9ULC5

Ensembl transtripts involved in fusion geneENST00000359213, ENST00000393765, 
ENST00000467604, ENST00000483209, 
ENST00000460321, ENST00000471675, 
Fusion gene scores* DoF score4 X 5 X 3=609 X 10 X 7=630
# samples 510
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: B4GALT4 [Title/Abstract] AND ACSL5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointB4GALT4(118945656)-ACSL5(114182083), # samples:3
Anticipated loss of major functional domain due to fusion event.B4GALT4-ACSL5 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
B4GALT4-ACSL5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
B4GALT4-ACSL5 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACSL5

GO:0001676

long-chain fatty acid metabolic process

24269233



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-5897-01AB4GALT4chr3

118945656

-ACSL5chr10

114182083

+
ChimerDB4LUSCTCGA-56-5897B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
ChimerDB4LUSCTCGA-56-5897B4GALT4chr3

118945656

-ACSL5chr10

114182083

+


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Fusion Gene ORF analysis for B4GALT4-ACSL5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000359213ENST00000354273B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000359213ENST00000354273B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000359213ENST00000356116B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000359213ENST00000356116B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000359213ENST00000369410B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000359213ENST00000369410B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000359213ENST00000393081B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000359213ENST00000393081B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000359213ENST00000433418B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000359213ENST00000433418B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000359213ENST00000479936B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000359213ENST00000479936B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000393765ENST00000354273B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000393765ENST00000354273B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000393765ENST00000356116B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000393765ENST00000356116B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000393765ENST00000369410B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000393765ENST00000369410B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000393765ENST00000393081B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000393765ENST00000393081B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000393765ENST00000433418B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000393765ENST00000433418B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000393765ENST00000479936B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000393765ENST00000479936B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000467604ENST00000354273B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000467604ENST00000354273B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000467604ENST00000356116B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000467604ENST00000356116B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000467604ENST00000369410B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000467604ENST00000369410B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000467604ENST00000393081B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000467604ENST00000393081B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000467604ENST00000433418B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000467604ENST00000433418B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000467604ENST00000479936B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000467604ENST00000479936B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000483209ENST00000354273B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000483209ENST00000354273B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000483209ENST00000356116B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000483209ENST00000356116B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000483209ENST00000369410B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000483209ENST00000369410B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000483209ENST00000393081B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000483209ENST00000393081B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000483209ENST00000433418B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000483209ENST00000433418B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5CDS-intronENST00000483209ENST00000479936B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5CDS-intronENST00000483209ENST00000479936B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5UTR-3CDSENST00000460321ENST00000354655B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5UTR-3CDSENST00000460321ENST00000354655B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5UTR-intronENST00000460321ENST00000354273B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5UTR-intronENST00000460321ENST00000354273B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5UTR-intronENST00000460321ENST00000356116B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5UTR-intronENST00000460321ENST00000356116B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5UTR-intronENST00000460321ENST00000369410B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5UTR-intronENST00000460321ENST00000369410B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5UTR-intronENST00000460321ENST00000393081B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5UTR-intronENST00000460321ENST00000393081B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5UTR-intronENST00000460321ENST00000433418B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5UTR-intronENST00000460321ENST00000433418B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
5UTR-intronENST00000460321ENST00000479936B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
5UTR-intronENST00000460321ENST00000479936B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
Frame-shiftENST00000359213ENST00000354655B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
Frame-shiftENST00000359213ENST00000354655B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
Frame-shiftENST00000393765ENST00000354655B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
Frame-shiftENST00000393765ENST00000354655B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
Frame-shiftENST00000467604ENST00000354655B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
Frame-shiftENST00000467604ENST00000354655B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
Frame-shiftENST00000483209ENST00000354655B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
Frame-shiftENST00000483209ENST00000354655B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
intron-3CDSENST00000471675ENST00000354655B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
intron-3CDSENST00000471675ENST00000354655B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
intron-intronENST00000471675ENST00000354273B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
intron-intronENST00000471675ENST00000354273B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
intron-intronENST00000471675ENST00000356116B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
intron-intronENST00000471675ENST00000356116B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
intron-intronENST00000471675ENST00000369410B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
intron-intronENST00000471675ENST00000369410B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
intron-intronENST00000471675ENST00000393081B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
intron-intronENST00000471675ENST00000393081B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
intron-intronENST00000471675ENST00000433418B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
intron-intronENST00000471675ENST00000433418B4GALT4chr3

118945655

-ACSL5chr10

114182082

+
intron-intronENST00000471675ENST00000479936B4GALT4chr3

118945656

-ACSL5chr10

114182083

+
intron-intronENST00000471675ENST00000479936B4GALT4chr3

118945655

-ACSL5chr10

114182082

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for B4GALT4-ACSL5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
B4GALT4chr3118945655-ACSL5chr10114182082+0.0083239540.9916761
B4GALT4chr3118945655-ACSL5chr10114182082+0.0083239540.9916761
B4GALT4chr3118945655-ACSL5chr10114182082+0.0083239540.9916761
B4GALT4chr3118945655-ACSL5chr10114182082+0.0083239540.9916761


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for B4GALT4-ACSL5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:118945656/:114182083)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ACSL5

Q9ULC5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:24269233, PubMed:22633490). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. {ECO:0000250, ECO:0000269|PubMed:17681178, ECO:0000269|PubMed:18806831, ECO:0000269|PubMed:19459852, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for B4GALT4-ACSL5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for B4GALT4-ACSL5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for B4GALT4-ACSL5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for B4GALT4-ACSL5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneB4GALT4C0033578Prostatic Neoplasms1CTD_human
HgeneB4GALT4C0376358Malignant neoplasm of prostate1CTD_human
TgeneC0003865Arthritis, Adjuvant-Induced1CTD_human
TgeneC0971858Arthritis, Collagen-Induced1CTD_human
TgeneC0993582Arthritis, Experimental1CTD_human