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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:ABCC3-TMEM104 (FusionGDB2 ID:HG8714TG54868)

Fusion Gene Summary for ABCC3-TMEM104

Fusion gene summary

Fusion gene information	Fusion gene name: ABCC3-TMEM104
	Fusion gene ID: hg8714tg54868
		Hgene	Tgene
	Gene symbol	ABCC3	TMEM104
	Gene ID	8714	54868
	Gene name	ATP binding cassette subfamily C member 3	transmembrane protein 104
	Synonyms	ABC31\|EST90757\|MLP2\|MOAT-D\|MRP3\|cMOAT2	-
	Cytomap	('ABCC3')('TMEM104') 17q21.33	17q25.1
	Type of gene	protein-coding	protein-coding
	Description	canalicular multispecific organic anion transporter 2ATP-binding cassette sub-family C member 3ATP-binding cassette, sub-family C (CFTR/MRP), member 3canicular multispecific organic anion transportermulti-specific organic anion transporter Dmultidrug	transmembrane protein 104
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000285238, ENST00000427699, ENST00000515707, ENST00000510891,
Fusion gene scores	* DoF score	16 X 12 X 7=1344	8 X 7 X 7=392
	# samples	18	9
	** MAII score	log2(18/1344*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/392*10)=-2.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ABCC3 [Title/Abstract] AND TMEM104 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ABCC3(48712342)-TMEM104(72815889), # samples:1
Anticipated loss of major functional domain due to fusion event.	ABCC3-TMEM104 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABCC3-TMEM104 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABCC3	GO:0042908	xenobiotic transport	18698235\|19334674

Fusion gene breakpoints across ABCC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TMEM104 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8373-01A	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+

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Fusion Gene ORF analysis for ABCC3-TMEM104

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000285238	ENST00000584171	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
5CDS-intron	ENST00000427699	ENST00000584171	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
5CDS-intron	ENST00000515707	ENST00000584171	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
In-frame	ENST00000285238	ENST00000335464	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
In-frame	ENST00000285238	ENST00000417024	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
In-frame	ENST00000285238	ENST00000582330	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
In-frame	ENST00000285238	ENST00000582773	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
In-frame	ENST00000427699	ENST00000335464	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
In-frame	ENST00000427699	ENST00000417024	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
In-frame	ENST00000427699	ENST00000582330	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
In-frame	ENST00000427699	ENST00000582773	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
In-frame	ENST00000515707	ENST00000335464	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
In-frame	ENST00000515707	ENST00000417024	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
In-frame	ENST00000515707	ENST00000582330	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
In-frame	ENST00000515707	ENST00000582773	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
intron-3CDS	ENST00000510891	ENST00000335464	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
intron-3CDS	ENST00000510891	ENST00000417024	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
intron-3CDS	ENST00000510891	ENST00000582330	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
intron-3CDS	ENST00000510891	ENST00000582773	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+
intron-intron	ENST00000510891	ENST00000584171	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000285238	ABCC3	chr17	48712342	+	ENST00000335464	TMEM104	chr17	72815889	+	4072	125	59	979	306
ENST00000285238	ABCC3	chr17	48712342	+	ENST00000417024	TMEM104	chr17	72815889	+	1085	125	340	879	179
ENST00000285238	ABCC3	chr17	48712342	+	ENST00000582773	TMEM104	chr17	72815889	+	1084	125	340	879	179
ENST00000285238	ABCC3	chr17	48712342	+	ENST00000582330	TMEM104	chr17	72815889	+	4046	125	1192	2	397
ENST00000515707	ABCC3	chr17	48712342	+	ENST00000335464	TMEM104	chr17	72815889	+	4041	94	49	948	299
ENST00000515707	ABCC3	chr17	48712342	+	ENST00000417024	TMEM104	chr17	72815889	+	1054	94	309	848	179
ENST00000515707	ABCC3	chr17	48712342	+	ENST00000582773	TMEM104	chr17	72815889	+	1053	94	309	848	179
ENST00000515707	ABCC3	chr17	48712342	+	ENST00000582330	TMEM104	chr17	72815889	+	4015	94	1161	1	387
ENST00000427699	ABCC3	chr17	48712342	+	ENST00000335464	TMEM104	chr17	72815889	+	4072	125	59	979	306
ENST00000427699	ABCC3	chr17	48712342	+	ENST00000417024	TMEM104	chr17	72815889	+	1085	125	340	879	179
ENST00000427699	ABCC3	chr17	48712342	+	ENST00000582773	TMEM104	chr17	72815889	+	1084	125	340	879	179
ENST00000427699	ABCC3	chr17	48712342	+	ENST00000582330	TMEM104	chr17	72815889	+	4046	125	1192	2	397

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000285238	ENST00000335464	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+	0.03251483	0.96748513
ENST00000285238	ENST00000417024	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+	0.32371703	0.676283
ENST00000285238	ENST00000582773	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+	0.3247124	0.6752876
ENST00000285238	ENST00000582330	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+	0.03565446	0.9643456
ENST00000515707	ENST00000335464	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+	0.03232362	0.96767634
ENST00000515707	ENST00000417024	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+	0.39367795	0.6063221
ENST00000515707	ENST00000582773	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+	0.39491972	0.6050803
ENST00000515707	ENST00000582330	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+	0.035478823	0.9645211
ENST00000427699	ENST00000335464	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+	0.03251483	0.96748513
ENST00000427699	ENST00000417024	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+	0.32371703	0.676283
ENST00000427699	ENST00000582773	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+	0.3247124	0.6752876
ENST00000427699	ENST00000582330	ABCC3	chr17	48712342	+	TMEM104	chr17	72815889	+	0.03565446	0.9643456

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Fusion Genomic Features for ABCC3-TMEM104

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ABCC3	chr17	48712342	+	TMEM104	chr17	72815888	+	0.000391601	0.99960846
ABCC3	chr17	48712342	+	TMEM104	chr17	72815888	+	0.000391601	0.99960846

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABCC3-TMEM104

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:48712342/chr17:72815889)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

226_233

212

497.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

255_276

212

497.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

298_306

212

497.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

328_354

212

497.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

376_397

212

497.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

419_421

212

497.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

443_470

212

497.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

492_496

212

497.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

226_233

212

497.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

255_276

212

497.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

298_306

212

497.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

328_354

212

497.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

376_397

212

497.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

419_421

212

497.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

443_470

212

497.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

492_496

212

497.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

226_233

212

315.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

255_276

212

315.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

298_306

212

315.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

328_354

212

315.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

376_397

212

315.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

419_421

212

315.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

443_470

212

315.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

492_496

212

315.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

234_254

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

277_297

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

307_327

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

355_375

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

398_418

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

422_442

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

471_491

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

234_254

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

277_297

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

307_327

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

355_375

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

398_418

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

422_442

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

471_491

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

234_254

212

315.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

277_297

212

315.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

307_327

212

315.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

355_375

212

315.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

398_418

212

315.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

422_442

212

315.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

471_491

212

315.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

1291_1523

1528.0

Domain

ABC transporter 2

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

311_594

1528.0

Domain

ABC transmembrane type-1 1

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

629_851

1528.0

Domain

ABC transporter 1

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

971_1252

1528.0

Domain

ABC transmembrane type-1 2

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

1291_1523

573.0

Domain

ABC transporter 2

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

311_594

573.0

Domain

ABC transmembrane type-1 1

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

629_851

573.0

Domain

ABC transporter 1

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

971_1252

573.0

Domain

ABC transmembrane type-1 2

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

1323_1330

1528.0

Nucleotide binding

ATP 2

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

661_668

1528.0

Nucleotide binding

ATP 1

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

1323_1330

573.0

Nucleotide binding

ATP 2

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

661_668

573.0

Nucleotide binding

ATP 1

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

1043_1085

1528.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

1107_1107

1528.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

1129_1199

1528.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

121_132

1528.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

1221_1222

1528.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

1244_1527

1528.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

154_171

1528.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

193_302

1528.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

1_32

1528.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

324_349

1528.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

371_426

1528.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

448_450

1528.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

472_533

1528.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

54_73

1528.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

555_576

1528.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

598_963

1528.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

95_99

1528.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

985_1021

1528.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

1043_1085

573.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

1107_1107

573.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

1129_1199

573.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

121_132

573.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

1221_1222

573.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

1244_1527

573.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

154_171

573.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

193_302

573.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

1_32

573.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

324_349

573.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

371_426

573.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

448_450

573.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

472_533

573.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

54_73

573.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

555_576

573.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

598_963

573.0

Topological domain

Cytoplasmic

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

95_99

573.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

985_1021

573.0

Topological domain

Extracellular

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

100_120

1528.0

Transmembrane

Helical%3B Name%3D3

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

1022_1042

1528.0

Transmembrane

Helical%3B Name%3D13

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

1086_1106

1528.0

Transmembrane

Helical%3B Name%3D14

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

1108_1128

1528.0

Transmembrane

Helical%3B Name%3D15

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

1200_1220

1528.0

Transmembrane

Helical%3B Name%3D16

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

1223_1243

1528.0

Transmembrane

Helical%3B Name%3D17

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

133_153

1528.0

Transmembrane

Helical%3B Name%3D4

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

172_192

1528.0

Transmembrane

Helical%3B Name%3D5

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

303_323

1528.0

Transmembrane

Helical%3B Name%3D6

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

33_53

1528.0

Transmembrane

Helical%3B Name%3D1

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

350_370

1528.0

Transmembrane

Helical%3B Name%3D7

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

427_447

1528.0

Transmembrane

Helical%3B Name%3D8

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

451_471

1528.0

Transmembrane

Helical%3B Name%3D9

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

534_554

1528.0

Transmembrane

Helical%3B Name%3D10

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

577_597

1528.0

Transmembrane

Helical%3B Name%3D11

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

74_94

1528.0

Transmembrane

Helical%3B Name%3D2

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000285238

964_984

1528.0

Transmembrane

Helical%3B Name%3D12

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

100_120

573.0

Transmembrane

Helical%3B Name%3D3

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

1022_1042

573.0

Transmembrane

Helical%3B Name%3D13

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

1086_1106

573.0

Transmembrane

Helical%3B Name%3D14

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

1108_1128

573.0

Transmembrane

Helical%3B Name%3D15

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

1200_1220

573.0

Transmembrane

Helical%3B Name%3D16

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

1223_1243

573.0

Transmembrane

Helical%3B Name%3D17

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

133_153

573.0

Transmembrane

Helical%3B Name%3D4

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

172_192

573.0

Transmembrane

Helical%3B Name%3D5

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

303_323

573.0

Transmembrane

Helical%3B Name%3D6

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

33_53

573.0

Transmembrane

Helical%3B Name%3D1

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

350_370

573.0

Transmembrane

Helical%3B Name%3D7

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

427_447

573.0

Transmembrane

Helical%3B Name%3D8

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

451_471

573.0

Transmembrane

Helical%3B Name%3D9

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

534_554

573.0

Transmembrane

Helical%3B Name%3D10

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

577_597

573.0

Transmembrane

Helical%3B Name%3D11

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

74_94

573.0

Transmembrane

Helical%3B Name%3D2

Hgene

ABCC3

chr17:48712342

chr17:72815889

ENST00000427699

964_984

573.0

Transmembrane

Helical%3B Name%3D12

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

168_204

212

497.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

1_10

212

497.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

32_36

212

497.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

58_146

212

497.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

168_204

212

497.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

1_10

212

497.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

32_36

212

497.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

58_146

212

497.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

168_204

212

315.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

1_10

212

315.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

32_36

212

315.0

Topological domain

Extracellular

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

58_146

212

315.0

Topological domain

Cytoplasmic

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

11_31

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

147_167

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

205_225

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000335464

37_57

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

11_31

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

147_167

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

205_225

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582330

37_57

212

497.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

11_31

212

315.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

147_167

212

315.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

205_225

212

315.0

Transmembrane

Helical

Tgene

TMEM104

chr17:48712342

chr17:72815889

ENST00000582773

37_57

212

315.0

Transmembrane

Helical

Top

Fusion Gene Sequence for ABCC3-TMEM104

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>263_263_1_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000285238_TMEM104_chr17_72815889_ENST00000335464_length(transcript)=4072nt_BP=125nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGCGATCTTCACTCTCCTCCTCGGACCGTTCACCTTCTTTGACGTCCAGAAGACCA
AGTACCTGCAGATCCTGACCTCTCTGATGAGATGGATCGCTTTCGCCGTCATGATTGTGCTGGCCCTGATCCGCATCGGGCACGGACAAG
GGGAGGGGCACCCGCCCCTGGCTGACTTCTCGGGGGTCCGGAACCTGTTTGGGGTGTGCGTCTACTCCTTCATGTGCCAGCACTCTCTGC
CATCCCTCATTACCCCCGTCTCCTCCAAGCGCCACCTCACAAGGCTGGTGTTCCTGGACTACGTGCTGATCCTGGCCTTCTACGGCCTCC
TCTCCTTCACCGCCATCTTCTGCTTCCGCGGCGACAGCCTCATGGACATGTACACCCTCAACTTCGCGCGCTGTGACGTCGTGGGCCTGG
CCGCTGTGCGCTTTTTCCTGGGCCTCTTCCCCGTCTTCACCATCAGCACCAACTTCCCCATCATTGCCGTGACCCTGCGCAACAACTGGA
AGACACTCTTCCACCGCGAGGGCGGCACGTACCCGTGGGTGGTGGACCGCGTCGTGTTTCCCACCATCACCCTGGTGCCGCCTGTGCTGG
TGGCCTTCTGCACCCACGACCTGGAGTCCCTGGTGGGCATCACAGGGGCCTACGCGGGCACCGGCATCCAGTACGTCATCCCCGCCTTCC
TGGTGTACCACTGCCGCAGGGACACCCAGCTGGCCTTTGGCTGTGGGGTCAGCAACAAGCACAGGTCCCCTTTCCGCCACACCTTCTGGG
TGGGCTTCGTGCTGCTCTGGGCTTTCTCCTGCTTCATTTTCGTCACGGCCAATATCATCCTCAGCGAGACCAAGCTCTGATGGCAGGACA
GGCAGGTCTAGTGACAGGAGGCATAGGGGCCCCAGCCCCACCCCTCGCCCGCAGAGCCCAGATTTAGTTGCTCCCAGGTCTTCATGGGGC
AGGTGGGACTGTGGCTCTAGGGGAAACCCCCTGTCCAGCTGGGGTTGTTCTCCCCACCCACCTTCCACCCAGTCTGCACCTGTCCTCACT
CCCCCGGGCAGCTCTCCCACCAGGTCCTTCTGCCTGGGTGACGCGTGGCTGCTCCCAAGTTCTAAGACTCATTACTGGAATCACACCTCT
CCCACATCTTCCAACACGCTTCACCCCCAACCCTACTTCCAGGGCGGGCTACTCCCTGCACAATGGGAGATGCAGTGCTGGCACTGCCAT
CATTTGTCCCAGACCCATGCCCCTCCCCTCTCCTGCCCCATCCTGCGTCCTTGTCTAAGAAACCTCCACTAGCAGCTGCTGCCTCTTCAG
AGGCGAATCCCAGGCTGGAAGTATCCTAGCCAGGTCTGCCTGTGACGGCAGGGCCCACCCTCCCACCAGGCCTGGGAGGCGGTAGGTGCC
ACCTCAGAGAGGGCCTGGCTGGCCCCATGACAAGAACAAGAAGTGCTAACTGGTACCAGAGTCCCCAGATAGAGCTGCGAGGGCCCTCGC
TGTGGGCGCGAGCTCCGGAGTAGCAGGCTGGATGGAGCATCCCTTCTACAGGGACACAGCCGCCTGCCAGCTGGGCCTAAAGTCTGGAGC
TTGTCTCTGAAAGGGACCGTCTGCTGCCCTCGCTGCCCCACTGGAGCCCTCAGGGCCTCCTACAGTGCAGGTGGTCCTACTAGAGGGAAG
CCATCCCCACCTGGCACCTCAGCGGCTTGGCAGTGACATGGCAGTGGGAGGGCTCTGAGGTTCCCACCCTGACAATGGTCAGGCTGCCCG
TGCTCCCACTCCAACACTAAAAGCGGCTCCCTTAGGGGCTGAGCGTGGGTGCTCAGTGTTCACGCTATATCCCTTGGGCAATGTGGGGTT
GGATGGGGCCCCCACTTCCATTCCCATGGAAGGAGGCCAGGTCCCCAGCCACCTCCCACTCAGCCATGCACGCACTTGCTGGGCTGGCCT
CCTGGGAAACACAGGTGACTCGAATGAACTCTGCATTTTCAACGTGCCTTCTACTGCTTCAGGACCTGGGGGTCCCCCTGACCCTCACTG
GCTTGCCCCCAGCCCTGGGCCTGGCCCCACCTGTCCTGGAGCCCAGAGCCCCTGGCCTGGAGCTACCTCTCTGGGGTGGGTCTCAGGCCC
CACCCCTCCCTCTTTTGAGTTCAGTGCCTTGCTCAGCCCCTCCCCTGTATCTCAGCGTCTTCAGACCTCTGACAGAGCGACGATGTAGGG
TCTCCCGGGGCCCAAGGTGGTCTCAGGGTCAGGGGTGGGATTTGCAGGGAACTCGGGGAGCCCACGGGCTGCGCCACCTCTGCCCTGGCA
GCTGAAGCCTGGGAGAGTCCCTGCGTGGTGTAATTGGCCTCAGCCCGCTTTCTCTGTGCCGTCGCACCTCAGTGTTTCTCATAGCTTGTC
CCCACGTGTCACTTTCCATCCACGGGAAAAACAAATGCCCCTTCTCCATCTATCATTGCGACTTCCTCCCAGGAGGCCTCTCAGGTTGGG
TAGAGCAGGGGCCTGCAGTGGTCAGGCCAAGAGCAAGGAAGACCTGGCTGCCCCACTGTGGCTGAAAACTCAAAACATCTGGAACTACCC
TTCTCCAATTACGTTCCCTCTTGCTTAAAGACAAAGCTAATTAAATCATCCTGCCACCCGAGGCTCCAAACCAAATCTTGGACGCAAATT
CATTAGCTTCATAAAGCCCAGGTTGATTTATGTGACAGTCTGGAACCGCCCAGCCATGGAGTCGGTGGCCGTGTTCCCTGCCCTGGAGGG
AACTGGCCAGCAGTGACCACATCGCTGATGCCAAGTGGGGACCCTCACCACTGCCGTTGTCTAGCTGCTTTGCTCCTCAGTGTCCTCCTG
CTGTAAGTCAGATGAGGTCACCTTCCTCTCCATCGATGCCAGGCTTCTGCCGCTGACGGCCAATGGGGCTTGGGGCCAGGGGCAGAGAAC
CCCAACAGCAAGAGAGCCCCAGGTGATGCTGGCTCTCCACGTGCATCCGGCACGTTTCACTGCAGCCATCATCAACTTGGCAAAGTAGGC
AAGCTCAGCTTGTGGTTTCCATTTTGCAGATGGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAGCCTGGCCCAG
GAGCAGGTGTCGTTGTGGAGGAAAGCTTAAACTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCCCCGGTGCAGG
CCAGGTCAAGGTGGGAGTAAACTTTCTTTGCCTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATGCCAGCAGCTC
CTGGCTGTTCCTCACCTGAGGCTAGAGCAGCAGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGCACTGCTGGGT
GGTGGAGGTGGGCAGTGGCACCATGACGGGCCCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCAACAGGCAAAG
GCCAGAGTCAGAGTGGTGGGGAGGACAGGGGCTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAGTGCCAGGCCT
GGGGGAAGTGGAAGCGTCCTGTCTGGGGGCAGATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGAGAGAGCTTGG
GATCCCTTCCACCTGGGGCCAATGGTGTTGATTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCATGGCATTGGG
TACTTTCTGCATTGGGACCAGGCAGCCGGGCCTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTAAAGTGGGGTA
ACAGCTATGTCACTGGCCAGTTGTGGGGATTAAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCAGTGATACCTG
TTTCCCACATCACTCACCAGCC

>263_263_1_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000285238_TMEM104_chr17_72815889_ENST00000335464_length(amino acids)=306AA_BP=22
MQPRLGPMDALCGSGELGSKFWAIFTLLLGPFTFFDVQKTKYLQILTSLMRWIAFAVMIVLALIRIGHGQGEGHPPLADFSGVRNLFGVC
VYSFMCQHSLPSLITPVSSKRHLTRLVFLDYVLILAFYGLLSFTAIFCFRGDSLMDMYTLNFARCDVVGLAAVRFFLGLFPVFTISTNFP
IIAVTLRNNWKTLFHREGGTYPWVVDRVVFPTITLVPPVLVAFCTHDLESLVGITGAYAGTGIQYVIPAFLVYHCRRDTQLAFGCGVSNK
HRSPFRHTFWVGFVLLWAFSCFIFVTANIILSETKL

--------------------------------------------------------------
>263_263_2_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000285238_TMEM104_chr17_72815889_ENST00000417024_length(transcript)=1085nt_BP=125nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGCGATCTTCACTCTCCTCCTCGGACCGTTCACCTTCTTTGACGTCCAGAAGACCA
AGTACCTGCAGATCCTGACCTCTCTGATGAGATGGATCGATGGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAG
CCTGGCCCAGGAGCAGGTGTCGTTGTGGAGGAAAGCTTAAACTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCC
CCGGTGCAGGCCAGGTCAAGGTGGGAGTAAACTTTCTTTGCCTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATG
CCAGCAGCTCCTGGCTGTTCCTCACCTGAGGCTAGAGCAGCAGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGC
ACTGCTGGGTGGTGGAGGTGGGCAGTGGCACCATGACGGGCCCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCA
ACAGGCAAAGGCCAGAGTCAGAGTGGTGGGGAGGACAGGGGCTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAG
TGCCAGGCCTGGGGGAAGTGGAAGCGTCCTGTCTGGGGGCAGATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGA
GAGAGCTTGGGATCCCTTCCACCTGGGGCCAATGGTGTTGATTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCA
TGGCATTGGGTACTTTCTGCATTGGGACCAGGCAGCCGGGCCTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTA
AAGTGGGGTAACAGCTATGTCACTGGCCAGTTGTGGGGATTAAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCA
GTGAT

>263_263_2_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000285238_TMEM104_chr17_72815889_ENST00000417024_length(amino acids)=179AA_BP=
MHGPRCPRCRPGQGGSKLSLPPSPQKHQTHLSPRASCQQLLAVPHLRLEQQLPAYRWGGWQVIDWEALLGGGGGQWHHDGPLATQLSSLR
GREQPRQQAKARVRVVGRTGAAAPLLESHCRGAVAGSARPGGSGSVLSGGRFPSKGDPWLRATGKLERAWDPFHLGPMVLIADWRGNLR

--------------------------------------------------------------
>263_263_3_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000285238_TMEM104_chr17_72815889_ENST00000582330_length(transcript)=4046nt_BP=125nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGCGATCTTCACTCTCCTCCTCGGACCGTTCACCTTCTTTGACGTCCAGAAGACCA
AGTACCTGCAGATCCTGACCTCTCTGATGAGATGGATCGCTTTCGCCGTCATGATTGTGCTGGCCCTGATCCGCATCGGGCACGGACAAG
GGGAGGGGCACCCGCCCCTGGCTGACTTCTCGGGGGTCCGGAACCTGTTTGGGGTGTGCGTCTACTCCTTCATGTGCCAGCACTCTCTGC
CATCCCTCATTACCCCCGTCTCCTCCAAGCGCCACCTCACAAGGCTGGTGTTCCTGGACTACGTGCTGATCCTGGCCTTCTACGGCCTCC
TCTCCTTCACCGCCATCTTCTGCTTCCGCGGCGACAGCCTCATGGACATGTACACCCTCAACTTCGCGCGCTGTGACGTCGTGGGCCTGG
CCGCTGTGCGCTTTTTCCTGGGCCTCTTCCCCGTCTTCACCATCAGCACCAACTTCCCCATCATTGCCGTGACCCTGCGCAACAACTGGA
AGACACTCTTCCACCGCGAGGGCGGCACGTACCCGTGGGTGGTGGACCGCGTCGTGTTTCCCACCATCACCCTGGTGCCGCCTGTGCTGG
TGGCCTTCTGCACCCACGACCTGGAGTCCCTGGTGGGCATCACAGGGGCCTACGCGGGCACCGGCATCCAGTACGTCATCCCCGCCTTCC
TGGTGTACCACTGCCGCAGGGACACCCAGCTGGCCTTTGGCTGTGGGGTCAGCAACAAGCACAGGTCCCCTTTCCGCCACACCTTCTGGG
TGGGCTTCGTGCTGCTCTGGGCTTTCTCCTGCTTCATTTTCGTCACGGCCAATATCATCCTCAGCGAGACCAAGCTCTGATGGCAGGACA
GGCAGGTCTAGTGACAGGAGGCATAGGGGCCCCAGCCCCACCCCTCGCCCGCAGAGCCCAGATTTAGTTGCTCCCAGGTCTTCATGGGGC
AGGTGGGACTGTGGCTCTAGGGGAAACCCCCTGTCCAGCTGGGGTTGTTCTCCCCACCCACCTTCCACCCAGTCTGCACCTGTCCTCACT
CCCCCGGGCAGCTCTCCCACCAGGTCCTTCTGCCTGGGTGACGCGTGGCTGCTCCCAAGTTCTAAGACTCATTACTGGAATCACACCTCT
CCCACATCTTCCAACACGCTTCACCCCCAACCCTACTTCCAGGGCGGGCTACTCCCTGCACAATGGGAGATGCAGTGCTGGCACTGCCAT
CATTTGTCCCAGACCCATGCCCCTCCCCTCTCCTGCCCCATCCTGCGTCCTTGTCTAAGAAACCTCCACTAGCAGCTGCTGCCTCTTCAG
AGGCGAATCCCAGGCTGGAAGTATCCTAGCCAGGTCTGCCTGTGACGGCAGGGCCCACCCTCCCACCAGGCCTGGGAGGCGGTAGGTGCC
ACCTCAGAGAGGGCCTGGCTGGCCCCATGACAAGAACAAGAAGTGCTAACTGGTACCAGAGTCCCCAGATAGAGCTGCGAGGGCCCTCGC
TGTGGGCGCGAGCTCCGGAGTAGCAGGCTGGATGGAGCATCCCTTCTACAGGGACACAGCCGCCTGCCAGCTGGGCCTAAAGTCTGGAGC
TTGTCTCTGAAAGGGACCGTCTGCTGCCCTCGCTGCCCCACTGGAGCCCTCAGGGCCTCCTACAGTGCAGGTGGTCCTACTAGAGGGAAG
CCATCCCCACCTGGCACCTCAGCGGCTTGGCAGTGACATGGCAGTGGGAGGGCTCTGAGGTTCCCACCCTGACAATGGTCAGGCTGCCCG
TGCTCCCACTCCAACACTAAAAGCGGCTCCCTTAGGGGCTGAGCGTGGGTGCTCAGTGTTCACGCTATATCCCTTGGGCAATGTGGGGTT
GGATGGGGCCCCCACTTCCATTCCCATGGAAGGAGGCCAGGTCCCCAGCCACCTCCCACTCAGCCATGCACGCACTTGCTGGGCTGGCCT
CCTGGGAAACACAGGTGACTCGAATGAACTCTGCATTTTCAACGTGCCTTCTACTGCTTCAGGACCTGGGGGTCCCCCTGACCCTCACTG
GCTTGCCCCCAGCCCTGGGCCTGGCCCCACCTGTCCTGGAGCCCAGAGCCCCTGGCCTGGAGCTACCTCTCTGGGGTGGGTCTCAGGCCC
CACCCCTCCCTCTTTTGAGTTCAGTGCCTTGCTCAGCCCCTCCCCTGTATCTCAGCGTCTTCAGACCTCTGACAGAGCGACGATGTAGGG
TCTCCCGGGGCCCAAGGTGGTCTCAGGGTCAGGGGTGGGATTTGCAGGGAACTCGGGGAGCCCACGGGCTGCGCCACCTCTGCCCTGGCA
GCTGAAGCCTGGGAGAGTCCCTGCGTGGTGTAATTGGCCTCAGCCCGCTTTCTCTGTGCCGTCGCACCTCAGTGTTTCTCATAGCTTGTC
CCCACGTGTCACTTTCCATCCACGGGAAAAACAAATGCCCCTTCTCCATCTATCATTGCGACTTCCTCCCAGGAGGCCTCTCAGGTTGGG
TAGAGCAGGGGCCTGCAGTGGTCAGGCCAAGAGCAAGGAAGACCTGGCTGCCCCACTGTGGCTGAAAACTCAAAACATCTGGAACTACCC
TTCTCCAATTACGTTCCCTCTTGCTTAAAGACAAAGCTAATTAAATCATCCTGCCACCCGAGGCTCCAAACCAAATCTTGGACGCAAATT
CATTAGCTTCATAAAGCCCAGGTTGATTTATGTGACAGTCTGGAACCGCCCAGCCATGGAGTCGGTGGCCGTGTTCCCTGCCCTGGAGGG
AACTGGCCAGCAGTGACCACATCGCTGATGCCAAGTGGGGACCCTCACCACTGCCGTTGTCTAGCTGCTTTGCTCCTCAGTGTCCTCCTG
CTGTAAGTCAGATGAGGTCACCTTCCTCTCCATCGATGCCAGGCTTCTGCCGCTGACGGCCAATGGGGCTTGGGGCCAGGGGCAGAGAAC
CCCAACAGCAAGAGAGCCCCAGGTGATGCTGGCTCTCCACGTGCATCCGGCACGTTTCACTGCAGCCATCATCAACTTGGCAAAGTAGGC
AAGCTCAGCTTGTGGTTTCCATTTTGCAGATGGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAGCCTGGCCCAG
GAGCAGGTGTCGTTGTGGAGGAAAGCTTAAACTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCCCCGGTGCAGG
CCAGGTCAAGGTGGGAGTAAACTTTCTTTGCCTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATGCCAGCAGCTC
CTGGCTGTTCCTCACCTGAGGCTAGAGCAGCAGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGCACTGCTGGGT
GGTGGAGGTGGGCAGTGGCACCATGACGGGCCCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCAACAGGCAAAG
GCCAGAGTCAGAGTGGTGGGGAGGACAGGGGCTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAGTGCCAGGCCT
GGGGGAAGTGGAAGCGTCCTGTCTGGGGGCAGATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGAGAGAGCTTGG
GATCCCTTCCACCTGGGGCCAATGGTGTTGATTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCATGGCATTGGG
TACTTTCTGCATTGGGACCAGGCAGCCGGGCCTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTAAAGTGGGGTA
ACAGCTATGTCACTGGCCAGTTGTGGGGATTAAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCAGTGATA

>263_263_3_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000285238_TMEM104_chr17_72815889_ENST00000582330_length(amino acids)=397AA_BP=1
MVGELPGGVRTGADWVEGGWGEQPQLDRGFPLEPQSHLPHEDLGATKSGLCGRGVGLGPLCLLSLDLPVLPSELGLAEDDIGRDENEAGE
SPEQHEAHPEGVAERGPVLVADPTAKGQLGVPAAVVHQEGGDDVLDAGARVGPCDAHQGLQVVGAEGHQHRRHQGDGGKHDAVHHPRVRA
ALAVEECLPVVAQGHGNDGEVGADGEDGEEAQEKAHSGQAHDVTAREVEGVHVHEAVAAEAEDGGEGEEAVEGQDQHVVQEHQPCEVALG
GDGGNEGWQRVLAHEGVDAHPKQVPDPREVSQGRVPLPLSVPDADQGQHNHDGESDPSHQRGQDLQVLGLLDVKEGERSEEESEDRPELG
AELPGTAQGVHGAEARLQGRRARSDPAAGRAGAGAAS

--------------------------------------------------------------
>263_263_4_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000285238_TMEM104_chr17_72815889_ENST00000582773_length(transcript)=1084nt_BP=125nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGCGATCTTCACTCTCCTCCTCGGACCGTTCACCTTCTTTGACGTCCAGAAGACCA
AGTACCTGCAGATCCTGACCTCTCTGATGAGATGGATCGATGGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAG
CCTGGCCCAGGAGCAGGTGTCGTTGTGGAGGAAAGCTTAAACTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCC
CCGGTGCAGGCCAGGTCAAGGTGGGAGTAAACTTTCTTTGCCTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATG
CCAGCAGCTCCTGGCTGTTCCTCACCTGAGGCTAGAGCAGCAGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGC
ACTGCTGGGTGGTGGAGGTGGGCAGTGGCACCATGACGGGCCCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCA
ACAGGCAAAGGCCAGAGTCAGAGTGGTGGGGAGGACAGGGGCTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAG
TGCCAGGCCTGGGGGAAGTGGAAGCGTCCTGTCTGGGGGCAGATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGA
GAGAGCTTGGGATCCCTTCCACCTGGGGCCAATGGTGTTGATTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCA
TGGCATTGGGTACTTTCTGCATTGGGACCAGGCAGCCGGGCCTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTA
AAGTGGGGTAACAGCTATGTCACTGGCCAGTTGTGGGGATTAAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCA
GTGA

>263_263_4_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000285238_TMEM104_chr17_72815889_ENST00000582773_length(amino acids)=179AA_BP=
MHGPRCPRCRPGQGGSKLSLPPSPQKHQTHLSPRASCQQLLAVPHLRLEQQLPAYRWGGWQVIDWEALLGGGGGQWHHDGPLATQLSSLR
GREQPRQQAKARVRVVGRTGAAAPLLESHCRGAVAGSARPGGSGSVLSGGRFPSKGDPWLRATGKLERAWDPFHLGPMVLIADWRGNLR

--------------------------------------------------------------
>263_263_5_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000427699_TMEM104_chr17_72815889_ENST00000335464_length(transcript)=4072nt_BP=125nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGCGATCTTCACTCTCCTCCTCGGACCGTTCACCTTCTTTGACGTCCAGAAGACCA
AGTACCTGCAGATCCTGACCTCTCTGATGAGATGGATCGCTTTCGCCGTCATGATTGTGCTGGCCCTGATCCGCATCGGGCACGGACAAG
GGGAGGGGCACCCGCCCCTGGCTGACTTCTCGGGGGTCCGGAACCTGTTTGGGGTGTGCGTCTACTCCTTCATGTGCCAGCACTCTCTGC
CATCCCTCATTACCCCCGTCTCCTCCAAGCGCCACCTCACAAGGCTGGTGTTCCTGGACTACGTGCTGATCCTGGCCTTCTACGGCCTCC
TCTCCTTCACCGCCATCTTCTGCTTCCGCGGCGACAGCCTCATGGACATGTACACCCTCAACTTCGCGCGCTGTGACGTCGTGGGCCTGG
CCGCTGTGCGCTTTTTCCTGGGCCTCTTCCCCGTCTTCACCATCAGCACCAACTTCCCCATCATTGCCGTGACCCTGCGCAACAACTGGA
AGACACTCTTCCACCGCGAGGGCGGCACGTACCCGTGGGTGGTGGACCGCGTCGTGTTTCCCACCATCACCCTGGTGCCGCCTGTGCTGG
TGGCCTTCTGCACCCACGACCTGGAGTCCCTGGTGGGCATCACAGGGGCCTACGCGGGCACCGGCATCCAGTACGTCATCCCCGCCTTCC
TGGTGTACCACTGCCGCAGGGACACCCAGCTGGCCTTTGGCTGTGGGGTCAGCAACAAGCACAGGTCCCCTTTCCGCCACACCTTCTGGG
TGGGCTTCGTGCTGCTCTGGGCTTTCTCCTGCTTCATTTTCGTCACGGCCAATATCATCCTCAGCGAGACCAAGCTCTGATGGCAGGACA
GGCAGGTCTAGTGACAGGAGGCATAGGGGCCCCAGCCCCACCCCTCGCCCGCAGAGCCCAGATTTAGTTGCTCCCAGGTCTTCATGGGGC
AGGTGGGACTGTGGCTCTAGGGGAAACCCCCTGTCCAGCTGGGGTTGTTCTCCCCACCCACCTTCCACCCAGTCTGCACCTGTCCTCACT
CCCCCGGGCAGCTCTCCCACCAGGTCCTTCTGCCTGGGTGACGCGTGGCTGCTCCCAAGTTCTAAGACTCATTACTGGAATCACACCTCT
CCCACATCTTCCAACACGCTTCACCCCCAACCCTACTTCCAGGGCGGGCTACTCCCTGCACAATGGGAGATGCAGTGCTGGCACTGCCAT
CATTTGTCCCAGACCCATGCCCCTCCCCTCTCCTGCCCCATCCTGCGTCCTTGTCTAAGAAACCTCCACTAGCAGCTGCTGCCTCTTCAG
AGGCGAATCCCAGGCTGGAAGTATCCTAGCCAGGTCTGCCTGTGACGGCAGGGCCCACCCTCCCACCAGGCCTGGGAGGCGGTAGGTGCC
ACCTCAGAGAGGGCCTGGCTGGCCCCATGACAAGAACAAGAAGTGCTAACTGGTACCAGAGTCCCCAGATAGAGCTGCGAGGGCCCTCGC
TGTGGGCGCGAGCTCCGGAGTAGCAGGCTGGATGGAGCATCCCTTCTACAGGGACACAGCCGCCTGCCAGCTGGGCCTAAAGTCTGGAGC
TTGTCTCTGAAAGGGACCGTCTGCTGCCCTCGCTGCCCCACTGGAGCCCTCAGGGCCTCCTACAGTGCAGGTGGTCCTACTAGAGGGAAG
CCATCCCCACCTGGCACCTCAGCGGCTTGGCAGTGACATGGCAGTGGGAGGGCTCTGAGGTTCCCACCCTGACAATGGTCAGGCTGCCCG
TGCTCCCACTCCAACACTAAAAGCGGCTCCCTTAGGGGCTGAGCGTGGGTGCTCAGTGTTCACGCTATATCCCTTGGGCAATGTGGGGTT
GGATGGGGCCCCCACTTCCATTCCCATGGAAGGAGGCCAGGTCCCCAGCCACCTCCCACTCAGCCATGCACGCACTTGCTGGGCTGGCCT
CCTGGGAAACACAGGTGACTCGAATGAACTCTGCATTTTCAACGTGCCTTCTACTGCTTCAGGACCTGGGGGTCCCCCTGACCCTCACTG
GCTTGCCCCCAGCCCTGGGCCTGGCCCCACCTGTCCTGGAGCCCAGAGCCCCTGGCCTGGAGCTACCTCTCTGGGGTGGGTCTCAGGCCC
CACCCCTCCCTCTTTTGAGTTCAGTGCCTTGCTCAGCCCCTCCCCTGTATCTCAGCGTCTTCAGACCTCTGACAGAGCGACGATGTAGGG
TCTCCCGGGGCCCAAGGTGGTCTCAGGGTCAGGGGTGGGATTTGCAGGGAACTCGGGGAGCCCACGGGCTGCGCCACCTCTGCCCTGGCA
GCTGAAGCCTGGGAGAGTCCCTGCGTGGTGTAATTGGCCTCAGCCCGCTTTCTCTGTGCCGTCGCACCTCAGTGTTTCTCATAGCTTGTC
CCCACGTGTCACTTTCCATCCACGGGAAAAACAAATGCCCCTTCTCCATCTATCATTGCGACTTCCTCCCAGGAGGCCTCTCAGGTTGGG
TAGAGCAGGGGCCTGCAGTGGTCAGGCCAAGAGCAAGGAAGACCTGGCTGCCCCACTGTGGCTGAAAACTCAAAACATCTGGAACTACCC
TTCTCCAATTACGTTCCCTCTTGCTTAAAGACAAAGCTAATTAAATCATCCTGCCACCCGAGGCTCCAAACCAAATCTTGGACGCAAATT
CATTAGCTTCATAAAGCCCAGGTTGATTTATGTGACAGTCTGGAACCGCCCAGCCATGGAGTCGGTGGCCGTGTTCCCTGCCCTGGAGGG
AACTGGCCAGCAGTGACCACATCGCTGATGCCAAGTGGGGACCCTCACCACTGCCGTTGTCTAGCTGCTTTGCTCCTCAGTGTCCTCCTG
CTGTAAGTCAGATGAGGTCACCTTCCTCTCCATCGATGCCAGGCTTCTGCCGCTGACGGCCAATGGGGCTTGGGGCCAGGGGCAGAGAAC
CCCAACAGCAAGAGAGCCCCAGGTGATGCTGGCTCTCCACGTGCATCCGGCACGTTTCACTGCAGCCATCATCAACTTGGCAAAGTAGGC
AAGCTCAGCTTGTGGTTTCCATTTTGCAGATGGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAGCCTGGCCCAG
GAGCAGGTGTCGTTGTGGAGGAAAGCTTAAACTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCCCCGGTGCAGG
CCAGGTCAAGGTGGGAGTAAACTTTCTTTGCCTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATGCCAGCAGCTC
CTGGCTGTTCCTCACCTGAGGCTAGAGCAGCAGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGCACTGCTGGGT
GGTGGAGGTGGGCAGTGGCACCATGACGGGCCCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCAACAGGCAAAG
GCCAGAGTCAGAGTGGTGGGGAGGACAGGGGCTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAGTGCCAGGCCT
GGGGGAAGTGGAAGCGTCCTGTCTGGGGGCAGATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGAGAGAGCTTGG
GATCCCTTCCACCTGGGGCCAATGGTGTTGATTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCATGGCATTGGG
TACTTTCTGCATTGGGACCAGGCAGCCGGGCCTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTAAAGTGGGGTA
ACAGCTATGTCACTGGCCAGTTGTGGGGATTAAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCAGTGATACCTG
TTTCCCACATCACTCACCAGCC

>263_263_5_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000427699_TMEM104_chr17_72815889_ENST00000335464_length(amino acids)=306AA_BP=22
MQPRLGPMDALCGSGELGSKFWAIFTLLLGPFTFFDVQKTKYLQILTSLMRWIAFAVMIVLALIRIGHGQGEGHPPLADFSGVRNLFGVC
VYSFMCQHSLPSLITPVSSKRHLTRLVFLDYVLILAFYGLLSFTAIFCFRGDSLMDMYTLNFARCDVVGLAAVRFFLGLFPVFTISTNFP
IIAVTLRNNWKTLFHREGGTYPWVVDRVVFPTITLVPPVLVAFCTHDLESLVGITGAYAGTGIQYVIPAFLVYHCRRDTQLAFGCGVSNK
HRSPFRHTFWVGFVLLWAFSCFIFVTANIILSETKL

--------------------------------------------------------------
>263_263_6_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000427699_TMEM104_chr17_72815889_ENST00000417024_length(transcript)=1085nt_BP=125nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGCGATCTTCACTCTCCTCCTCGGACCGTTCACCTTCTTTGACGTCCAGAAGACCA
AGTACCTGCAGATCCTGACCTCTCTGATGAGATGGATCGATGGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAG
CCTGGCCCAGGAGCAGGTGTCGTTGTGGAGGAAAGCTTAAACTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCC
CCGGTGCAGGCCAGGTCAAGGTGGGAGTAAACTTTCTTTGCCTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATG
CCAGCAGCTCCTGGCTGTTCCTCACCTGAGGCTAGAGCAGCAGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGC
ACTGCTGGGTGGTGGAGGTGGGCAGTGGCACCATGACGGGCCCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCA
ACAGGCAAAGGCCAGAGTCAGAGTGGTGGGGAGGACAGGGGCTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAG
TGCCAGGCCTGGGGGAAGTGGAAGCGTCCTGTCTGGGGGCAGATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGA
GAGAGCTTGGGATCCCTTCCACCTGGGGCCAATGGTGTTGATTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCA
TGGCATTGGGTACTTTCTGCATTGGGACCAGGCAGCCGGGCCTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTA
AAGTGGGGTAACAGCTATGTCACTGGCCAGTTGTGGGGATTAAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCA
GTGAT

>263_263_6_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000427699_TMEM104_chr17_72815889_ENST00000417024_length(amino acids)=179AA_BP=
MHGPRCPRCRPGQGGSKLSLPPSPQKHQTHLSPRASCQQLLAVPHLRLEQQLPAYRWGGWQVIDWEALLGGGGGQWHHDGPLATQLSSLR
GREQPRQQAKARVRVVGRTGAAAPLLESHCRGAVAGSARPGGSGSVLSGGRFPSKGDPWLRATGKLERAWDPFHLGPMVLIADWRGNLR

--------------------------------------------------------------
>263_263_7_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000427699_TMEM104_chr17_72815889_ENST00000582330_length(transcript)=4046nt_BP=125nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGCGATCTTCACTCTCCTCCTCGGACCGTTCACCTTCTTTGACGTCCAGAAGACCA
AGTACCTGCAGATCCTGACCTCTCTGATGAGATGGATCGCTTTCGCCGTCATGATTGTGCTGGCCCTGATCCGCATCGGGCACGGACAAG
GGGAGGGGCACCCGCCCCTGGCTGACTTCTCGGGGGTCCGGAACCTGTTTGGGGTGTGCGTCTACTCCTTCATGTGCCAGCACTCTCTGC
CATCCCTCATTACCCCCGTCTCCTCCAAGCGCCACCTCACAAGGCTGGTGTTCCTGGACTACGTGCTGATCCTGGCCTTCTACGGCCTCC
TCTCCTTCACCGCCATCTTCTGCTTCCGCGGCGACAGCCTCATGGACATGTACACCCTCAACTTCGCGCGCTGTGACGTCGTGGGCCTGG
CCGCTGTGCGCTTTTTCCTGGGCCTCTTCCCCGTCTTCACCATCAGCACCAACTTCCCCATCATTGCCGTGACCCTGCGCAACAACTGGA
AGACACTCTTCCACCGCGAGGGCGGCACGTACCCGTGGGTGGTGGACCGCGTCGTGTTTCCCACCATCACCCTGGTGCCGCCTGTGCTGG
TGGCCTTCTGCACCCACGACCTGGAGTCCCTGGTGGGCATCACAGGGGCCTACGCGGGCACCGGCATCCAGTACGTCATCCCCGCCTTCC
TGGTGTACCACTGCCGCAGGGACACCCAGCTGGCCTTTGGCTGTGGGGTCAGCAACAAGCACAGGTCCCCTTTCCGCCACACCTTCTGGG
TGGGCTTCGTGCTGCTCTGGGCTTTCTCCTGCTTCATTTTCGTCACGGCCAATATCATCCTCAGCGAGACCAAGCTCTGATGGCAGGACA
GGCAGGTCTAGTGACAGGAGGCATAGGGGCCCCAGCCCCACCCCTCGCCCGCAGAGCCCAGATTTAGTTGCTCCCAGGTCTTCATGGGGC
AGGTGGGACTGTGGCTCTAGGGGAAACCCCCTGTCCAGCTGGGGTTGTTCTCCCCACCCACCTTCCACCCAGTCTGCACCTGTCCTCACT
CCCCCGGGCAGCTCTCCCACCAGGTCCTTCTGCCTGGGTGACGCGTGGCTGCTCCCAAGTTCTAAGACTCATTACTGGAATCACACCTCT
CCCACATCTTCCAACACGCTTCACCCCCAACCCTACTTCCAGGGCGGGCTACTCCCTGCACAATGGGAGATGCAGTGCTGGCACTGCCAT
CATTTGTCCCAGACCCATGCCCCTCCCCTCTCCTGCCCCATCCTGCGTCCTTGTCTAAGAAACCTCCACTAGCAGCTGCTGCCTCTTCAG
AGGCGAATCCCAGGCTGGAAGTATCCTAGCCAGGTCTGCCTGTGACGGCAGGGCCCACCCTCCCACCAGGCCTGGGAGGCGGTAGGTGCC
ACCTCAGAGAGGGCCTGGCTGGCCCCATGACAAGAACAAGAAGTGCTAACTGGTACCAGAGTCCCCAGATAGAGCTGCGAGGGCCCTCGC
TGTGGGCGCGAGCTCCGGAGTAGCAGGCTGGATGGAGCATCCCTTCTACAGGGACACAGCCGCCTGCCAGCTGGGCCTAAAGTCTGGAGC
TTGTCTCTGAAAGGGACCGTCTGCTGCCCTCGCTGCCCCACTGGAGCCCTCAGGGCCTCCTACAGTGCAGGTGGTCCTACTAGAGGGAAG
CCATCCCCACCTGGCACCTCAGCGGCTTGGCAGTGACATGGCAGTGGGAGGGCTCTGAGGTTCCCACCCTGACAATGGTCAGGCTGCCCG
TGCTCCCACTCCAACACTAAAAGCGGCTCCCTTAGGGGCTGAGCGTGGGTGCTCAGTGTTCACGCTATATCCCTTGGGCAATGTGGGGTT
GGATGGGGCCCCCACTTCCATTCCCATGGAAGGAGGCCAGGTCCCCAGCCACCTCCCACTCAGCCATGCACGCACTTGCTGGGCTGGCCT
CCTGGGAAACACAGGTGACTCGAATGAACTCTGCATTTTCAACGTGCCTTCTACTGCTTCAGGACCTGGGGGTCCCCCTGACCCTCACTG
GCTTGCCCCCAGCCCTGGGCCTGGCCCCACCTGTCCTGGAGCCCAGAGCCCCTGGCCTGGAGCTACCTCTCTGGGGTGGGTCTCAGGCCC
CACCCCTCCCTCTTTTGAGTTCAGTGCCTTGCTCAGCCCCTCCCCTGTATCTCAGCGTCTTCAGACCTCTGACAGAGCGACGATGTAGGG
TCTCCCGGGGCCCAAGGTGGTCTCAGGGTCAGGGGTGGGATTTGCAGGGAACTCGGGGAGCCCACGGGCTGCGCCACCTCTGCCCTGGCA
GCTGAAGCCTGGGAGAGTCCCTGCGTGGTGTAATTGGCCTCAGCCCGCTTTCTCTGTGCCGTCGCACCTCAGTGTTTCTCATAGCTTGTC
CCCACGTGTCACTTTCCATCCACGGGAAAAACAAATGCCCCTTCTCCATCTATCATTGCGACTTCCTCCCAGGAGGCCTCTCAGGTTGGG
TAGAGCAGGGGCCTGCAGTGGTCAGGCCAAGAGCAAGGAAGACCTGGCTGCCCCACTGTGGCTGAAAACTCAAAACATCTGGAACTACCC
TTCTCCAATTACGTTCCCTCTTGCTTAAAGACAAAGCTAATTAAATCATCCTGCCACCCGAGGCTCCAAACCAAATCTTGGACGCAAATT
CATTAGCTTCATAAAGCCCAGGTTGATTTATGTGACAGTCTGGAACCGCCCAGCCATGGAGTCGGTGGCCGTGTTCCCTGCCCTGGAGGG
AACTGGCCAGCAGTGACCACATCGCTGATGCCAAGTGGGGACCCTCACCACTGCCGTTGTCTAGCTGCTTTGCTCCTCAGTGTCCTCCTG
CTGTAAGTCAGATGAGGTCACCTTCCTCTCCATCGATGCCAGGCTTCTGCCGCTGACGGCCAATGGGGCTTGGGGCCAGGGGCAGAGAAC
CCCAACAGCAAGAGAGCCCCAGGTGATGCTGGCTCTCCACGTGCATCCGGCACGTTTCACTGCAGCCATCATCAACTTGGCAAAGTAGGC
AAGCTCAGCTTGTGGTTTCCATTTTGCAGATGGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAGCCTGGCCCAG
GAGCAGGTGTCGTTGTGGAGGAAAGCTTAAACTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCCCCGGTGCAGG
CCAGGTCAAGGTGGGAGTAAACTTTCTTTGCCTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATGCCAGCAGCTC
CTGGCTGTTCCTCACCTGAGGCTAGAGCAGCAGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGCACTGCTGGGT
GGTGGAGGTGGGCAGTGGCACCATGACGGGCCCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCAACAGGCAAAG
GCCAGAGTCAGAGTGGTGGGGAGGACAGGGGCTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAGTGCCAGGCCT
GGGGGAAGTGGAAGCGTCCTGTCTGGGGGCAGATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGAGAGAGCTTGG
GATCCCTTCCACCTGGGGCCAATGGTGTTGATTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCATGGCATTGGG
TACTTTCTGCATTGGGACCAGGCAGCCGGGCCTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTAAAGTGGGGTA
ACAGCTATGTCACTGGCCAGTTGTGGGGATTAAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCAGTGATA

>263_263_7_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000427699_TMEM104_chr17_72815889_ENST00000582330_length(amino acids)=397AA_BP=1
MVGELPGGVRTGADWVEGGWGEQPQLDRGFPLEPQSHLPHEDLGATKSGLCGRGVGLGPLCLLSLDLPVLPSELGLAEDDIGRDENEAGE
SPEQHEAHPEGVAERGPVLVADPTAKGQLGVPAAVVHQEGGDDVLDAGARVGPCDAHQGLQVVGAEGHQHRRHQGDGGKHDAVHHPRVRA
ALAVEECLPVVAQGHGNDGEVGADGEDGEEAQEKAHSGQAHDVTAREVEGVHVHEAVAAEAEDGGEGEEAVEGQDQHVVQEHQPCEVALG
GDGGNEGWQRVLAHEGVDAHPKQVPDPREVSQGRVPLPLSVPDADQGQHNHDGESDPSHQRGQDLQVLGLLDVKEGERSEEESEDRPELG
AELPGTAQGVHGAEARLQGRRARSDPAAGRAGAGAAS

--------------------------------------------------------------
>263_263_8_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000427699_TMEM104_chr17_72815889_ENST00000582773_length(transcript)=1084nt_BP=125nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGCGATCTTCACTCTCCTCCTCGGACCGTTCACCTTCTTTGACGTCCAGAAGACCA
AGTACCTGCAGATCCTGACCTCTCTGATGAGATGGATCGATGGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAG
CCTGGCCCAGGAGCAGGTGTCGTTGTGGAGGAAAGCTTAAACTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCC
CCGGTGCAGGCCAGGTCAAGGTGGGAGTAAACTTTCTTTGCCTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATG
CCAGCAGCTCCTGGCTGTTCCTCACCTGAGGCTAGAGCAGCAGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGC
ACTGCTGGGTGGTGGAGGTGGGCAGTGGCACCATGACGGGCCCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCA
ACAGGCAAAGGCCAGAGTCAGAGTGGTGGGGAGGACAGGGGCTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAG
TGCCAGGCCTGGGGGAAGTGGAAGCGTCCTGTCTGGGGGCAGATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGA
GAGAGCTTGGGATCCCTTCCACCTGGGGCCAATGGTGTTGATTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCA
TGGCATTGGGTACTTTCTGCATTGGGACCAGGCAGCCGGGCCTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTA
AAGTGGGGTAACAGCTATGTCACTGGCCAGTTGTGGGGATTAAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCA
GTGA

>263_263_8_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000427699_TMEM104_chr17_72815889_ENST00000582773_length(amino acids)=179AA_BP=
MHGPRCPRCRPGQGGSKLSLPPSPQKHQTHLSPRASCQQLLAVPHLRLEQQLPAYRWGGWQVIDWEALLGGGGGQWHHDGPLATQLSSLR
GREQPRQQAKARVRVVGRTGAAAPLLESHCRGAVAGSARPGGSGSVLSGGRFPSKGDPWLRATGKLERAWDPFHLGPMVLIADWRGNLR

--------------------------------------------------------------
>263_263_9_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000515707_TMEM104_chr17_72815889_ENST00000335464_length(transcript)=4041nt_BP=94nt
CGGGGGCAGGGAGACCGGACCCAGAGGCACTGGGCCGCGCCTCGGCCCCATGGACGCCCTGTGCGGTTCCGGGGAGCTCGGCTCCAAGTT
CTGGGCGATCTTCACTCTCCTCCTCGGACCGTTCACCTTCTTTGACGTCCAGAAGACCAAGTACCTGCAGATCCTGACCTCTCTGATGAG
ATGGATCGCTTTCGCCGTCATGATTGTGCTGGCCCTGATCCGCATCGGGCACGGACAAGGGGAGGGGCACCCGCCCCTGGCTGACTTCTC
GGGGGTCCGGAACCTGTTTGGGGTGTGCGTCTACTCCTTCATGTGCCAGCACTCTCTGCCATCCCTCATTACCCCCGTCTCCTCCAAGCG
CCACCTCACAAGGCTGGTGTTCCTGGACTACGTGCTGATCCTGGCCTTCTACGGCCTCCTCTCCTTCACCGCCATCTTCTGCTTCCGCGG
CGACAGCCTCATGGACATGTACACCCTCAACTTCGCGCGCTGTGACGTCGTGGGCCTGGCCGCTGTGCGCTTTTTCCTGGGCCTCTTCCC
CGTCTTCACCATCAGCACCAACTTCCCCATCATTGCCGTGACCCTGCGCAACAACTGGAAGACACTCTTCCACCGCGAGGGCGGCACGTA
CCCGTGGGTGGTGGACCGCGTCGTGTTTCCCACCATCACCCTGGTGCCGCCTGTGCTGGTGGCCTTCTGCACCCACGACCTGGAGTCCCT
GGTGGGCATCACAGGGGCCTACGCGGGCACCGGCATCCAGTACGTCATCCCCGCCTTCCTGGTGTACCACTGCCGCAGGGACACCCAGCT
GGCCTTTGGCTGTGGGGTCAGCAACAAGCACAGGTCCCCTTTCCGCCACACCTTCTGGGTGGGCTTCGTGCTGCTCTGGGCTTTCTCCTG
CTTCATTTTCGTCACGGCCAATATCATCCTCAGCGAGACCAAGCTCTGATGGCAGGACAGGCAGGTCTAGTGACAGGAGGCATAGGGGCC
CCAGCCCCACCCCTCGCCCGCAGAGCCCAGATTTAGTTGCTCCCAGGTCTTCATGGGGCAGGTGGGACTGTGGCTCTAGGGGAAACCCCC
TGTCCAGCTGGGGTTGTTCTCCCCACCCACCTTCCACCCAGTCTGCACCTGTCCTCACTCCCCCGGGCAGCTCTCCCACCAGGTCCTTCT
GCCTGGGTGACGCGTGGCTGCTCCCAAGTTCTAAGACTCATTACTGGAATCACACCTCTCCCACATCTTCCAACACGCTTCACCCCCAAC
CCTACTTCCAGGGCGGGCTACTCCCTGCACAATGGGAGATGCAGTGCTGGCACTGCCATCATTTGTCCCAGACCCATGCCCCTCCCCTCT
CCTGCCCCATCCTGCGTCCTTGTCTAAGAAACCTCCACTAGCAGCTGCTGCCTCTTCAGAGGCGAATCCCAGGCTGGAAGTATCCTAGCC
AGGTCTGCCTGTGACGGCAGGGCCCACCCTCCCACCAGGCCTGGGAGGCGGTAGGTGCCACCTCAGAGAGGGCCTGGCTGGCCCCATGAC
AAGAACAAGAAGTGCTAACTGGTACCAGAGTCCCCAGATAGAGCTGCGAGGGCCCTCGCTGTGGGCGCGAGCTCCGGAGTAGCAGGCTGG
ATGGAGCATCCCTTCTACAGGGACACAGCCGCCTGCCAGCTGGGCCTAAAGTCTGGAGCTTGTCTCTGAAAGGGACCGTCTGCTGCCCTC
GCTGCCCCACTGGAGCCCTCAGGGCCTCCTACAGTGCAGGTGGTCCTACTAGAGGGAAGCCATCCCCACCTGGCACCTCAGCGGCTTGGC
AGTGACATGGCAGTGGGAGGGCTCTGAGGTTCCCACCCTGACAATGGTCAGGCTGCCCGTGCTCCCACTCCAACACTAAAAGCGGCTCCC
TTAGGGGCTGAGCGTGGGTGCTCAGTGTTCACGCTATATCCCTTGGGCAATGTGGGGTTGGATGGGGCCCCCACTTCCATTCCCATGGAA
GGAGGCCAGGTCCCCAGCCACCTCCCACTCAGCCATGCACGCACTTGCTGGGCTGGCCTCCTGGGAAACACAGGTGACTCGAATGAACTC
TGCATTTTCAACGTGCCTTCTACTGCTTCAGGACCTGGGGGTCCCCCTGACCCTCACTGGCTTGCCCCCAGCCCTGGGCCTGGCCCCACC
TGTCCTGGAGCCCAGAGCCCCTGGCCTGGAGCTACCTCTCTGGGGTGGGTCTCAGGCCCCACCCCTCCCTCTTTTGAGTTCAGTGCCTTG
CTCAGCCCCTCCCCTGTATCTCAGCGTCTTCAGACCTCTGACAGAGCGACGATGTAGGGTCTCCCGGGGCCCAAGGTGGTCTCAGGGTCA
GGGGTGGGATTTGCAGGGAACTCGGGGAGCCCACGGGCTGCGCCACCTCTGCCCTGGCAGCTGAAGCCTGGGAGAGTCCCTGCGTGGTGT
AATTGGCCTCAGCCCGCTTTCTCTGTGCCGTCGCACCTCAGTGTTTCTCATAGCTTGTCCCCACGTGTCACTTTCCATCCACGGGAAAAA
CAAATGCCCCTTCTCCATCTATCATTGCGACTTCCTCCCAGGAGGCCTCTCAGGTTGGGTAGAGCAGGGGCCTGCAGTGGTCAGGCCAAG
AGCAAGGAAGACCTGGCTGCCCCACTGTGGCTGAAAACTCAAAACATCTGGAACTACCCTTCTCCAATTACGTTCCCTCTTGCTTAAAGA
CAAAGCTAATTAAATCATCCTGCCACCCGAGGCTCCAAACCAAATCTTGGACGCAAATTCATTAGCTTCATAAAGCCCAGGTTGATTTAT
GTGACAGTCTGGAACCGCCCAGCCATGGAGTCGGTGGCCGTGTTCCCTGCCCTGGAGGGAACTGGCCAGCAGTGACCACATCGCTGATGC
CAAGTGGGGACCCTCACCACTGCCGTTGTCTAGCTGCTTTGCTCCTCAGTGTCCTCCTGCTGTAAGTCAGATGAGGTCACCTTCCTCTCC
ATCGATGCCAGGCTTCTGCCGCTGACGGCCAATGGGGCTTGGGGCCAGGGGCAGAGAACCCCAACAGCAAGAGAGCCCCAGGTGATGCTG
GCTCTCCACGTGCATCCGGCACGTTTCACTGCAGCCATCATCAACTTGGCAAAGTAGGCAAGCTCAGCTTGTGGTTTCCATTTTGCAGAT
GGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAGCCTGGCCCAGGAGCAGGTGTCGTTGTGGAGGAAAGCTTAAA
CTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCCCCGGTGCAGGCCAGGTCAAGGTGGGAGTAAACTTTCTTTGC
CTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATGCCAGCAGCTCCTGGCTGTTCCTCACCTGAGGCTAGAGCAGC
AGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGCACTGCTGGGTGGTGGAGGTGGGCAGTGGCACCATGACGGGC
CCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCAACAGGCAAAGGCCAGAGTCAGAGTGGTGGGGAGGACAGGGG
CTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAGTGCCAGGCCTGGGGGAAGTGGAAGCGTCCTGTCTGGGGGCA
GATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGAGAGAGCTTGGGATCCCTTCCACCTGGGGCCAATGGTGTTGA
TTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCATGGCATTGGGTACTTTCTGCATTGGGACCAGGCAGCCGGGC
CTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTAAAGTGGGGTAACAGCTATGTCACTGGCCAGTTGTGGGGATT
AAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCAGTGATACCTGTTTCCCACATCACTCACCAGCC

>263_263_9_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000515707_TMEM104_chr17_72815889_ENST00000335464_length(amino acids)=299AA_BP=15
MDALCGSGELGSKFWAIFTLLLGPFTFFDVQKTKYLQILTSLMRWIAFAVMIVLALIRIGHGQGEGHPPLADFSGVRNLFGVCVYSFMCQ
HSLPSLITPVSSKRHLTRLVFLDYVLILAFYGLLSFTAIFCFRGDSLMDMYTLNFARCDVVGLAAVRFFLGLFPVFTISTNFPIIAVTLR
NNWKTLFHREGGTYPWVVDRVVFPTITLVPPVLVAFCTHDLESLVGITGAYAGTGIQYVIPAFLVYHCRRDTQLAFGCGVSNKHRSPFRH
TFWVGFVLLWAFSCFIFVTANIILSETKL

--------------------------------------------------------------
>263_263_10_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000515707_TMEM104_chr17_72815889_ENST00000417024_length(transcript)=1054nt_BP=94nt
CGGGGGCAGGGAGACCGGACCCAGAGGCACTGGGCCGCGCCTCGGCCCCATGGACGCCCTGTGCGGTTCCGGGGAGCTCGGCTCCAAGTT
CTGGGCGATCTTCACTCTCCTCCTCGGACCGTTCACCTTCTTTGACGTCCAGAAGACCAAGTACCTGCAGATCCTGACCTCTCTGATGAG
ATGGATCGATGGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAGCCTGGCCCAGGAGCAGGTGTCGTTGTGGAGG
AAAGCTTAAACTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCCCCGGTGCAGGCCAGGTCAAGGTGGGAGTAAA
CTTTCTTTGCCTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATGCCAGCAGCTCCTGGCTGTTCCTCACCTGAGG
CTAGAGCAGCAGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGCACTGCTGGGTGGTGGAGGTGGGCAGTGGCAC
CATGACGGGCCCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCAACAGGCAAAGGCCAGAGTCAGAGTGGTGGGG
AGGACAGGGGCTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAGTGCCAGGCCTGGGGGAAGTGGAAGCGTCCTG
TCTGGGGGCAGATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGAGAGAGCTTGGGATCCCTTCCACCTGGGGCCA
ATGGTGTTGATTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCATGGCATTGGGTACTTTCTGCATTGGGACCAG
GCAGCCGGGCCTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTAAAGTGGGGTAACAGCTATGTCACTGGCCAGT
TGTGGGGATTAAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCAGTGAT

>263_263_10_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000515707_TMEM104_chr17_72815889_ENST00000417024_length(amino acids)=179AA_BP=
MHGPRCPRCRPGQGGSKLSLPPSPQKHQTHLSPRASCQQLLAVPHLRLEQQLPAYRWGGWQVIDWEALLGGGGGQWHHDGPLATQLSSLR
GREQPRQQAKARVRVVGRTGAAAPLLESHCRGAVAGSARPGGSGSVLSGGRFPSKGDPWLRATGKLERAWDPFHLGPMVLIADWRGNLR

--------------------------------------------------------------
>263_263_11_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000515707_TMEM104_chr17_72815889_ENST00000582330_length(transcript)=4015nt_BP=94nt
CGGGGGCAGGGAGACCGGACCCAGAGGCACTGGGCCGCGCCTCGGCCCCATGGACGCCCTGTGCGGTTCCGGGGAGCTCGGCTCCAAGTT
CTGGGCGATCTTCACTCTCCTCCTCGGACCGTTCACCTTCTTTGACGTCCAGAAGACCAAGTACCTGCAGATCCTGACCTCTCTGATGAG
ATGGATCGCTTTCGCCGTCATGATTGTGCTGGCCCTGATCCGCATCGGGCACGGACAAGGGGAGGGGCACCCGCCCCTGGCTGACTTCTC
GGGGGTCCGGAACCTGTTTGGGGTGTGCGTCTACTCCTTCATGTGCCAGCACTCTCTGCCATCCCTCATTACCCCCGTCTCCTCCAAGCG
CCACCTCACAAGGCTGGTGTTCCTGGACTACGTGCTGATCCTGGCCTTCTACGGCCTCCTCTCCTTCACCGCCATCTTCTGCTTCCGCGG
CGACAGCCTCATGGACATGTACACCCTCAACTTCGCGCGCTGTGACGTCGTGGGCCTGGCCGCTGTGCGCTTTTTCCTGGGCCTCTTCCC
CGTCTTCACCATCAGCACCAACTTCCCCATCATTGCCGTGACCCTGCGCAACAACTGGAAGACACTCTTCCACCGCGAGGGCGGCACGTA
CCCGTGGGTGGTGGACCGCGTCGTGTTTCCCACCATCACCCTGGTGCCGCCTGTGCTGGTGGCCTTCTGCACCCACGACCTGGAGTCCCT
GGTGGGCATCACAGGGGCCTACGCGGGCACCGGCATCCAGTACGTCATCCCCGCCTTCCTGGTGTACCACTGCCGCAGGGACACCCAGCT
GGCCTTTGGCTGTGGGGTCAGCAACAAGCACAGGTCCCCTTTCCGCCACACCTTCTGGGTGGGCTTCGTGCTGCTCTGGGCTTTCTCCTG
CTTCATTTTCGTCACGGCCAATATCATCCTCAGCGAGACCAAGCTCTGATGGCAGGACAGGCAGGTCTAGTGACAGGAGGCATAGGGGCC
CCAGCCCCACCCCTCGCCCGCAGAGCCCAGATTTAGTTGCTCCCAGGTCTTCATGGGGCAGGTGGGACTGTGGCTCTAGGGGAAACCCCC
TGTCCAGCTGGGGTTGTTCTCCCCACCCACCTTCCACCCAGTCTGCACCTGTCCTCACTCCCCCGGGCAGCTCTCCCACCAGGTCCTTCT
GCCTGGGTGACGCGTGGCTGCTCCCAAGTTCTAAGACTCATTACTGGAATCACACCTCTCCCACATCTTCCAACACGCTTCACCCCCAAC
CCTACTTCCAGGGCGGGCTACTCCCTGCACAATGGGAGATGCAGTGCTGGCACTGCCATCATTTGTCCCAGACCCATGCCCCTCCCCTCT
CCTGCCCCATCCTGCGTCCTTGTCTAAGAAACCTCCACTAGCAGCTGCTGCCTCTTCAGAGGCGAATCCCAGGCTGGAAGTATCCTAGCC
AGGTCTGCCTGTGACGGCAGGGCCCACCCTCCCACCAGGCCTGGGAGGCGGTAGGTGCCACCTCAGAGAGGGCCTGGCTGGCCCCATGAC
AAGAACAAGAAGTGCTAACTGGTACCAGAGTCCCCAGATAGAGCTGCGAGGGCCCTCGCTGTGGGCGCGAGCTCCGGAGTAGCAGGCTGG
ATGGAGCATCCCTTCTACAGGGACACAGCCGCCTGCCAGCTGGGCCTAAAGTCTGGAGCTTGTCTCTGAAAGGGACCGTCTGCTGCCCTC
GCTGCCCCACTGGAGCCCTCAGGGCCTCCTACAGTGCAGGTGGTCCTACTAGAGGGAAGCCATCCCCACCTGGCACCTCAGCGGCTTGGC
AGTGACATGGCAGTGGGAGGGCTCTGAGGTTCCCACCCTGACAATGGTCAGGCTGCCCGTGCTCCCACTCCAACACTAAAAGCGGCTCCC
TTAGGGGCTGAGCGTGGGTGCTCAGTGTTCACGCTATATCCCTTGGGCAATGTGGGGTTGGATGGGGCCCCCACTTCCATTCCCATGGAA
GGAGGCCAGGTCCCCAGCCACCTCCCACTCAGCCATGCACGCACTTGCTGGGCTGGCCTCCTGGGAAACACAGGTGACTCGAATGAACTC
TGCATTTTCAACGTGCCTTCTACTGCTTCAGGACCTGGGGGTCCCCCTGACCCTCACTGGCTTGCCCCCAGCCCTGGGCCTGGCCCCACC
TGTCCTGGAGCCCAGAGCCCCTGGCCTGGAGCTACCTCTCTGGGGTGGGTCTCAGGCCCCACCCCTCCCTCTTTTGAGTTCAGTGCCTTG
CTCAGCCCCTCCCCTGTATCTCAGCGTCTTCAGACCTCTGACAGAGCGACGATGTAGGGTCTCCCGGGGCCCAAGGTGGTCTCAGGGTCA
GGGGTGGGATTTGCAGGGAACTCGGGGAGCCCACGGGCTGCGCCACCTCTGCCCTGGCAGCTGAAGCCTGGGAGAGTCCCTGCGTGGTGT
AATTGGCCTCAGCCCGCTTTCTCTGTGCCGTCGCACCTCAGTGTTTCTCATAGCTTGTCCCCACGTGTCACTTTCCATCCACGGGAAAAA
CAAATGCCCCTTCTCCATCTATCATTGCGACTTCCTCCCAGGAGGCCTCTCAGGTTGGGTAGAGCAGGGGCCTGCAGTGGTCAGGCCAAG
AGCAAGGAAGACCTGGCTGCCCCACTGTGGCTGAAAACTCAAAACATCTGGAACTACCCTTCTCCAATTACGTTCCCTCTTGCTTAAAGA
CAAAGCTAATTAAATCATCCTGCCACCCGAGGCTCCAAACCAAATCTTGGACGCAAATTCATTAGCTTCATAAAGCCCAGGTTGATTTAT
GTGACAGTCTGGAACCGCCCAGCCATGGAGTCGGTGGCCGTGTTCCCTGCCCTGGAGGGAACTGGCCAGCAGTGACCACATCGCTGATGC
CAAGTGGGGACCCTCACCACTGCCGTTGTCTAGCTGCTTTGCTCCTCAGTGTCCTCCTGCTGTAAGTCAGATGAGGTCACCTTCCTCTCC
ATCGATGCCAGGCTTCTGCCGCTGACGGCCAATGGGGCTTGGGGCCAGGGGCAGAGAACCCCAACAGCAAGAGAGCCCCAGGTGATGCTG
GCTCTCCACGTGCATCCGGCACGTTTCACTGCAGCCATCATCAACTTGGCAAAGTAGGCAAGCTCAGCTTGTGGTTTCCATTTTGCAGAT
GGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAGCCTGGCCCAGGAGCAGGTGTCGTTGTGGAGGAAAGCTTAAA
CTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCCCCGGTGCAGGCCAGGTCAAGGTGGGAGTAAACTTTCTTTGC
CTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATGCCAGCAGCTCCTGGCTGTTCCTCACCTGAGGCTAGAGCAGC
AGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGCACTGCTGGGTGGTGGAGGTGGGCAGTGGCACCATGACGGGC
CCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCAACAGGCAAAGGCCAGAGTCAGAGTGGTGGGGAGGACAGGGG
CTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAGTGCCAGGCCTGGGGGAAGTGGAAGCGTCCTGTCTGGGGGCA
GATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGAGAGAGCTTGGGATCCCTTCCACCTGGGGCCAATGGTGTTGA
TTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCATGGCATTGGGTACTTTCTGCATTGGGACCAGGCAGCCGGGC
CTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTAAAGTGGGGTAACAGCTATGTCACTGGCCAGTTGTGGGGATT
AAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCAGTGATA

>263_263_11_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000515707_TMEM104_chr17_72815889_ENST00000582330_length(amino acids)=387AA_BP=1
MVGELPGGVRTGADWVEGGWGEQPQLDRGFPLEPQSHLPHEDLGATKSGLCGRGVGLGPLCLLSLDLPVLPSELGLAEDDIGRDENEAGE
SPEQHEAHPEGVAERGPVLVADPTAKGQLGVPAAVVHQEGGDDVLDAGARVGPCDAHQGLQVVGAEGHQHRRHQGDGGKHDAVHHPRVRA
ALAVEECLPVVAQGHGNDGEVGADGEDGEEAQEKAHSGQAHDVTAREVEGVHVHEAVAAEAEDGGEGEEAVEGQDQHVVQEHQPCEVALG
GDGGNEGWQRVLAHEGVDAHPKQVPDPREVSQGRVPLPLSVPDADQGQHNHDGESDPSHQRGQDLQVLGLLDVKEGERSEEESEDRPELG
AELPGTAQGVHGAEARPSASGSGLPAP

--------------------------------------------------------------
>263_263_12_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000515707_TMEM104_chr17_72815889_ENST00000582773_length(transcript)=1053nt_BP=94nt
CGGGGGCAGGGAGACCGGACCCAGAGGCACTGGGCCGCGCCTCGGCCCCATGGACGCCCTGTGCGGTTCCGGGGAGCTCGGCTCCAAGTT
CTGGGCGATCTTCACTCTCCTCCTCGGACCGTTCACCTTCTTTGACGTCCAGAAGACCAAGTACCTGCAGATCCTGACCTCTCTGATGAG
ATGGATCGATGGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAGCCTGGCCCAGGAGCAGGTGTCGTTGTGGAGG
AAAGCTTAAACTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCCCCGGTGCAGGCCAGGTCAAGGTGGGAGTAAA
CTTTCTTTGCCTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATGCCAGCAGCTCCTGGCTGTTCCTCACCTGAGG
CTAGAGCAGCAGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGCACTGCTGGGTGGTGGAGGTGGGCAGTGGCAC
CATGACGGGCCCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCAACAGGCAAAGGCCAGAGTCAGAGTGGTGGGG
AGGACAGGGGCTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAGTGCCAGGCCTGGGGGAAGTGGAAGCGTCCTG
TCTGGGGGCAGATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGAGAGAGCTTGGGATCCCTTCCACCTGGGGCCA
ATGGTGTTGATTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCATGGCATTGGGTACTTTCTGCATTGGGACCAG
GCAGCCGGGCCTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTAAAGTGGGGTAACAGCTATGTCACTGGCCAGT
TGTGGGGATTAAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCAGTGA

>263_263_12_ABCC3-TMEM104_ABCC3_chr17_48712342_ENST00000515707_TMEM104_chr17_72815889_ENST00000582773_length(amino acids)=179AA_BP=
MHGPRCPRCRPGQGGSKLSLPPSPQKHQTHLSPRASCQQLLAVPHLRLEQQLPAYRWGGWQVIDWEALLGGGGGQWHHDGPLATQLSSLR
GREQPRQQAKARVRVVGRTGAAAPLLESHCRGAVAGSARPGGSGSVLSGGRFPSKGDPWLRATGKLERAWDPFHLGPMVLIADWRGNLR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ABCC3-TMEM104

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ABCC3-TMEM104

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ABCC3-TMEM104

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ABCC3	C0003873	Rheumatoid Arthritis	1	CTD_human
Hgene	ABCC3	C0008370	Cholestasis	1	CTD_human
Hgene	ABCC3	C0009402	Colorectal Carcinoma	1	CTD_human
Hgene	ABCC3	C0009404	Colorectal Neoplasms	1	CTD_human
Hgene	ABCC3	C0019209	Hepatomegaly	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ABCC3-TMEM104 (FusionGDB2 ID:HG8714TG54868)

Fusion Gene Summary for ABCC3-TMEM104

Fusion Gene ORF analysis for ABCC3-TMEM104

Fusion Genomic Features for ABCC3-TMEM104

Fusion Protein Features for ABCC3-TMEM104

Fusion Gene Sequence for ABCC3-TMEM104

Fusion Gene PPI Analysis for ABCC3-TMEM104

Related Drugs for ABCC3-TMEM104

Related Diseases for ABCC3-TMEM104

Fusion Gene Studies
in Kim Lab