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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EED-TPCN2 (FusionGDB2 ID:HG8726TG219931)

Fusion Gene Summary for EED-TPCN2

check button Fusion gene summary
Fusion gene informationFusion gene name: EED-TPCN2
Fusion gene ID: hg8726tg219931
HgeneTgene
Gene symbol

EED

TPCN2

Gene ID

8726

219931

Gene nameembryonic ectoderm developmenttwo pore segment channel 2
SynonymsCOGIS|HEED|WAIT1SHEP10|TPC2
Cytomap('EED')('TPCN2')

11q14.2

11q13.3

Type of geneprotein-codingprotein-coding
Descriptionpolycomb protein EEDWD protein associating with integrin cytoplasmic tails 1embryonic ectoderm development proteintwo pore calcium channel protein 2voltage-dependent calcium channel protein TPC2
Modification date2020031320200320
UniProtAcc

O75530

.
Ensembl transtripts involved in fusion geneENST00000263360, ENST00000327320, 
ENST00000351625, ENST00000528180, 
ENST00000527888, 
Fusion gene scores* DoF score5 X 5 X 3=7511 X 9 X 6=594
# samples 512
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/594*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EED [Title/Abstract] AND TPCN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEED(85956385)-TPCN2(68834971), # samples:1
Anticipated loss of major functional domain due to fusion event.EED-TPCN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EED-TPCN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTPCN2

GO:0006874

cellular calcium ion homeostasis

19387438


check buttonFusion gene breakpoints across EED (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TPCN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HI-7171-01AEEDchr11

85956385

+TPCN2chr11

68834971

+


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Fusion Gene ORF analysis for EED-TPCN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000263360ENST00000442692EEDchr11

85956385

+TPCN2chr11

68834971

+
5CDS-3UTRENST00000327320ENST00000442692EEDchr11

85956385

+TPCN2chr11

68834971

+
5CDS-3UTRENST00000351625ENST00000442692EEDchr11

85956385

+TPCN2chr11

68834971

+
5CDS-3UTRENST00000528180ENST00000442692EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000263360ENST00000294309EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000263360ENST00000542467EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000327320ENST00000294309EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000327320ENST00000542467EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000351625ENST00000294309EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000351625ENST00000542467EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000528180ENST00000294309EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000528180ENST00000542467EEDchr11

85956385

+TPCN2chr11

68834971

+
intron-3CDSENST00000527888ENST00000294309EEDchr11

85956385

+TPCN2chr11

68834971

+
intron-3CDSENST00000527888ENST00000542467EEDchr11

85956385

+TPCN2chr11

68834971

+
intron-3UTRENST00000527888ENST00000442692EEDchr11

85956385

+TPCN2chr11

68834971

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263360EEDchr1185956385+ENST00000294309TPCN2chr1168834971+29048003142332672
ENST00000263360EEDchr1185956385+ENST00000542467TPCN2chr1168834971+20378003141786490
ENST00000528180EEDchr1185956385+ENST00000294309TPCN2chr1168834971+26955911052123672
ENST00000528180EEDchr1185956385+ENST00000542467TPCN2chr1168834971+18285911051577490
ENST00000327320EEDchr1185956385+ENST00000294309TPCN2chr1168834971+2308204271736569
ENST00000327320EEDchr1185956385+ENST00000542467TPCN2chr1168834971+1441204271190387
ENST00000351625EEDchr1185956385+ENST00000294309TPCN2chr1168834971+222512171653548
ENST00000351625EEDchr1185956385+ENST00000542467TPCN2chr1168834971+135812171107366

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263360ENST00000294309EEDchr1185956385+TPCN2chr1168834971+0.0049414150.99505866
ENST00000263360ENST00000542467EEDchr1185956385+TPCN2chr1168834971+0.0032550730.9967449
ENST00000528180ENST00000294309EEDchr1185956385+TPCN2chr1168834971+0.0056986260.9943013
ENST00000528180ENST00000542467EEDchr1185956385+TPCN2chr1168834971+0.0038190630.996181
ENST00000327320ENST00000294309EEDchr1185956385+TPCN2chr1168834971+0.0073651270.99263483
ENST00000327320ENST00000542467EEDchr1185956385+TPCN2chr1168834971+0.0048563090.9951438
ENST00000351625ENST00000294309EEDchr1185956385+TPCN2chr1168834971+0.0072522140.99274784
ENST00000351625ENST00000542467EEDchr1185956385+TPCN2chr1168834971+0.0054909180.99450916

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Fusion Genomic Features for EED-TPCN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EEDchr1185956385+TPCN2chr1168834970+7.42E-080.9999999
EEDchr1185956385+TPCN2chr1168834970+7.42E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EED-TPCN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:85956385/chr11:68834971)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EED

O75530

.
FUNCTION: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:9584199}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625255_279242753.0IntramembraneHelical%3B Pore-forming
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625636_658242753.0IntramembraneHelical%3B Pore-forming
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625240_254242753.0Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625280_289242753.0Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625311_436242753.0Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625460_465242753.0Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625487_502242753.0Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625524_554242753.0Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625576_580242753.0Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625602_635242753.0Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625659_673242753.0Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625695_752242753.0Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625290_310242753.0TransmembraneHelical%3B Name%3DS6 of repeat I
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625437_459242753.0TransmembraneHelical%3B Name%3DS1 of repeat II
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625466_486242753.0TransmembraneHelical%3B Name%3DS2 of repeat II
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625503_523242753.0TransmembraneHelical%3B Name%3DS3 of repeat II
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625555_575242753.0TransmembraneHelical%3B Name%3DS4 of repeat II
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625581_601242753.0TransmembraneHelical%3B Name%3DS5 of repeat II
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625674_694242753.0TransmembraneHelical%3B Name%3DS6 of repeat II

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+112142_18538442.0RepeatNote=WD 2
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+112188_22838442.0RepeatNote=WD 3
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+112234_27538442.0RepeatNote=WD 4
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+112304_34138442.0RepeatNote=WD 5
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+112359_39938442.0RepeatNote=WD 6
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+112408_44138442.0RepeatNote=WD 7
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+11291_13438442.0RepeatNote=WD 1
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+111142_18538401.0RepeatNote=WD 2
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+111188_22838401.0RepeatNote=WD 3
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+111234_27538401.0RepeatNote=WD 4
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+111304_34138401.0RepeatNote=WD 5
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+111359_39938401.0RepeatNote=WD 6
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+111408_44138401.0RepeatNote=WD 7
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+11191_13438401.0RepeatNote=WD 1
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+113142_18538467.0RepeatNote=WD 2
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+113188_22838467.0RepeatNote=WD 3
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+113234_27538467.0RepeatNote=WD 4
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+113304_34138467.0RepeatNote=WD 5
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+113359_39938467.0RepeatNote=WD 6
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+113408_44138467.0RepeatNote=WD 7
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+11391_13438467.0RepeatNote=WD 1
TgeneTPCN2chr11:85956385chr11:68834971ENST0000029430962517_20242753.0Compositional biasNote=Poly-Gly
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625106_127242753.0Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625149_155242753.0Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625177_183242753.0Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST000002943096251_84242753.0Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625205_218242753.0Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625128_148242753.0TransmembraneHelical%3B Name%3DS2 of repeat I
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625156_176242753.0TransmembraneHelical%3B Name%3DS3 of repeat I
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625184_204242753.0TransmembraneHelical%3B Name%3DS4 of repeat I
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309625219_239242753.0TransmembraneHelical%3B Name%3DS5 of repeat I
TgeneTPCN2chr11:85956385chr11:68834971ENST0000029430962585_105242753.0TransmembraneHelical%3B Name%3DS1 of repeat I


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Fusion Gene Sequence for EED-TPCN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25019_25019_1_EED-TPCN2_EED_chr11_85956385_ENST00000263360_TPCN2_chr11_68834971_ENST00000294309_length(transcript)=2904nt_BP=800nt
ATTCGCCAGATGGGGGAAGCCAGGGGGAAGCAGGTTACTGTTTTTGCATTTCTATCTTCAAGGAAGAATTAGGTTATGAATAGTTCCGTG
AATAGTCAGGAAGCGCTGTCCTCCAAGTTCAAGATTAAGGAAACGTGGCATGCACAGCTAAAGCAAGAGGTGACGTCTTGTATCTTCCCC
CGTTTCCTGGGACATTGGTGGTGTAGCCCATTCCACAGACTTTCGCTCCCTAGCAGCGGGTCGGAGATCGAAGGAACGGGCCAATTGCGG
CTGAAACGTCTTTGGAAGGAGGAAGGGGGTGAGGGAGCATCCCTTTGAGTTTCGCCTCTTCTCGAGGCGGTGGTGGGAAGGGAGACATAC
TTAATACTGCCCTCTTAATCCAACGGACCTTACATCGTGTAGACTGCCGGGAGGGCGGCGGGAAAAGGGCAAGACGGGAGTTGGGGAAGG
GAAGGAGCCAGGAAGCCGCGCGGGAGGGCGCGCGCGCGCGCCCCTTTTTCAGCAGTGTGGCGGGGTCGCACGCACGCCCGCCTCGGCGGC
TGGGCGCGATTTGCGACAGTGGGGGGGGCGGTGGAGGTGGCGGCGGCAGCGGCAACTTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGG
CGGTGTGGCGGAGGCCCCGCCCCAGGCGGCAGGAACCTGGAGGGAGGCGGAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGG
GAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAATCCAGACCTCTCTGGAGACGAGAATCAGGATGATG
GGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCG
ATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACC
TGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGG
CTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGC
TTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGT
TTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCC
AGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGG
ATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGC
TCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGG
AGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGCCGGAGATGGTGGGCCTGCTGTCGCTGTGGGACATGACCCGCA
TGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCATGAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGG
TGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGTATTTGCCATCATTGGGATCAACTTGTTTAGAGGCGTCATTG
TGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGCCCTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACT
TCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGTGAACAACTGGCAGGTGTTTCTGGATGCATATCGGCGCTACT
CAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGTCTGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGA
ACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGT
TCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGG
GCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGG
CAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGC
TGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTGCTTCAGTGAGAATTCCCTCGTCGACTCCACAGGGACCTTTC
AGACAAAAATGCAAGAAGCAGCGGCCTCCCCTGTCCCCTGCAGCTTCCGTGGTGCCTTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCT
GACCAGGGCCTGCACAGGTTAACCGTCAGACTTCCGGGGCATTCAGGTGGGGATGCTGGTGGTTTGACATGGAGAGAACCTTGACTGTGT
TTTATTATTTCATGGCTTGTATGAGTGTGACTGGGTGTGTTTCTTTAGGGTTCTGATTGCCAGTTATTTTCATCAATAAGTCTTGCAAAG
AATGGGATTGTCATTCTTCACTTC

>25019_25019_1_EED-TPCN2_EED_chr11_85956385_ENST00000263360_TPCN2_chr11_68834971_ENST00000294309_length(amino acids)=672AA_BP=71
MSFASSRGGGGKGDILNTALLIQRTLHRVDCREGGGKRARRELGKGRSQEAAREGARARPFFSSVAGSHARPPRRLGAICDSGGGGGGGG
GSGNFAASSGRACLTAVWRRPRPRRQEPGGRRRNMSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPE
SLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGA
FPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNL
IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW
RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGS
APCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPL
AGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPHLWLCR

--------------------------------------------------------------
>25019_25019_2_EED-TPCN2_EED_chr11_85956385_ENST00000263360_TPCN2_chr11_68834971_ENST00000542467_length(transcript)=2037nt_BP=800nt
ATTCGCCAGATGGGGGAAGCCAGGGGGAAGCAGGTTACTGTTTTTGCATTTCTATCTTCAAGGAAGAATTAGGTTATGAATAGTTCCGTG
AATAGTCAGGAAGCGCTGTCCTCCAAGTTCAAGATTAAGGAAACGTGGCATGCACAGCTAAAGCAAGAGGTGACGTCTTGTATCTTCCCC
CGTTTCCTGGGACATTGGTGGTGTAGCCCATTCCACAGACTTTCGCTCCCTAGCAGCGGGTCGGAGATCGAAGGAACGGGCCAATTGCGG
CTGAAACGTCTTTGGAAGGAGGAAGGGGGTGAGGGAGCATCCCTTTGAGTTTCGCCTCTTCTCGAGGCGGTGGTGGGAAGGGAGACATAC
TTAATACTGCCCTCTTAATCCAACGGACCTTACATCGTGTAGACTGCCGGGAGGGCGGCGGGAAAAGGGCAAGACGGGAGTTGGGGAAGG
GAAGGAGCCAGGAAGCCGCGCGGGAGGGCGCGCGCGCGCGCCCCTTTTTCAGCAGTGTGGCGGGGTCGCACGCACGCCCGCCTCGGCGGC
TGGGCGCGATTTGCGACAGTGGGGGGGGCGGTGGAGGTGGCGGCGGCAGCGGCAACTTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGG
CGGTGTGGCGGAGGCCCCGCCCCAGGCGGCAGGAACCTGGAGGGAGGCGGAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGG
GAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAATCCAGACCTCTCTGGAGACGAGAATCAGGATGATG
GGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCG
ATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACC
TGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGG
CTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGC
TTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGT
TTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCC
AGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGG
ATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGC
TCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGAACTTCC
TTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGG
ATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCC
GTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAA
GAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGG
TGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTGCTTCAGTGAGAATT

>25019_25019_2_EED-TPCN2_EED_chr11_85956385_ENST00000263360_TPCN2_chr11_68834971_ENST00000542467_length(amino acids)=490AA_BP=71
MSFASSRGGGGKGDILNTALLIQRTLHRVDCREGGGKRARRELGKGRSQEAAREGARARPFFSSVAGSHARPPRRLGAICDSGGGGGGGG
GSGNFAASSGRACLTAVWRRPRPRRQEPGGRRRNMSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPE
SLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGA
FPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNL
IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLNFLHKWDPRSHLQPLAG
TPEATYQMTVELLFRDILEEPGEDELTERLSQHPHLWLCR

--------------------------------------------------------------
>25019_25019_3_EED-TPCN2_EED_chr11_85956385_ENST00000327320_TPCN2_chr11_68834971_ENST00000294309_length(transcript)=2308nt_BP=204nt
TTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGGCGGTGTGGCGGAGGCCCCGCCCCAGGCGGCAGGAACCTGGAGGGAGGCGGAGGAAT
ATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAAT
CCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCC
CTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTC
TTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAG
ACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCA
GTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGT
TCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGG
CCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCA
AACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGC
GTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTT
GACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGCCGGAGATG
GTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCATGAAGCTG
ATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGTATTTGCC
ATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGCCCTGTGGG
AGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGTGAACAAC
TGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGTCTGTCATC
TGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCA
GAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAG
CACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCGT
CATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCCT
TTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTGCTTCAGT
GAGAATTCCCTCGTCGACTCCACAGGGACCTTTCAGACAAAAATGCAAGAAGCAGCGGCCTCCCCTGTCCCCTGCAGCTTCCGTGGTGCC
TTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCTGACCAGGGCCTGCACAGGTTAACCGTCAGACTTCCGGGGCATTCAGGTGGGGATGC
TGGTGGTTTGACATGGAGAGAACCTTGACTGTGTTTTATTATTTCATGGCTTGTATGAGTGTGACTGGGTGTGTTTCTTTAGGGTTCTGA
TTGCCAGTTATTTTCATCAATAAGTCTTGCAAAGAATGGGATTGTCATTCTTCACTTC

>25019_25019_3_EED-TPCN2_EED_chr11_85956385_ENST00000327320_TPCN2_chr11_68834971_ENST00000294309_length(amino acids)=569AA_BP=59
MTAVWRRPRPRRQEPGGRRRNMSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPESLTSLLVLLTTAN
NPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL
QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL
VLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM
TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWA
NNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVE
LLFRDILEEPGEDELTERLSQHPHLWLCR

--------------------------------------------------------------
>25019_25019_4_EED-TPCN2_EED_chr11_85956385_ENST00000327320_TPCN2_chr11_68834971_ENST00000542467_length(transcript)=1441nt_BP=204nt
TTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGGCGGTGTGGCGGAGGCCCCGCCCCAGGCGGCAGGAACCTGGAGGGAGGCGGAGGAAT
ATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAAT
CCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCC
CTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTC
TTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAG
ACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCA
GTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGT
TCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGG
CCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCA
AACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGC
GTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTT
GACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCC
ACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCG
CACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCGTCATGGA
AGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCCTTTGCGT
GTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTGCTTCAGTGAGAAT
T

>25019_25019_4_EED-TPCN2_EED_chr11_85956385_ENST00000327320_TPCN2_chr11_68834971_ENST00000542467_length(amino acids)=387AA_BP=59
MTAVWRRPRPRRQEPGGRRRNMSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPESLTSLLVLLTTAN
NPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL
QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL
VLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLNFLHKWDPRSHLQPLAGTPEATYQMTVELL
FRDILEEPGEDELTERLSQHPHLWLCR

--------------------------------------------------------------
>25019_25019_5_EED-TPCN2_EED_chr11_85956385_ENST00000351625_TPCN2_chr11_68834971_ENST00000294309_length(transcript)=2225nt_BP=121nt
GAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAA
CAGCAATCCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCT
GACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTT
CATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATC
TCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCC
TCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAA
GGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCC
GCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGC
CCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCT
CAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAA
CGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGCC
GGAGATGGTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCAT
GAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGT
ATTTGCCATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGCC
CTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGT
GAACAACTGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGTC
TGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGG
GACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCT
GAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGG
TGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACC
AAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTG
CTTCAGTGAGAATTCCCTCGTCGACTCCACAGGGACCTTTCAGACAAAAATGCAAGAAGCAGCGGCCTCCCCTGTCCCCTGCAGCTTCCG
TGGTGCCTTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCTGACCAGGGCCTGCACAGGTTAACCGTCAGACTTCCGGGGCATTCAGGTG
GGGATGCTGGTGGTTTGACATGGAGAGAACCTTGACTGTGTTTTATTATTTCATGGCTTGTATGAGTGTGACTGGGTGTGTTTCTTTAGG
GTTCTGATTGCCAGTTATTTTCATCAATAAGTCTTGCAAAGAATGGGATTGTCATTCTTCACTTC

>25019_25019_5_EED-TPCN2_EED_chr11_85956385_ENST00000351625_TPCN2_chr11_68834971_ENST00000294309_length(amino acids)=548AA_BP=38
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV
FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR
SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC
VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL
MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNN
WQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQ
HPHLWLCR

--------------------------------------------------------------
>25019_25019_6_EED-TPCN2_EED_chr11_85956385_ENST00000351625_TPCN2_chr11_68834971_ENST00000542467_length(transcript)=1358nt_BP=121nt
GAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAA
CAGCAATCCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCT
GACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTT
CATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATC
TCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCC
TCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAA
GGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCC
GCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGC
CCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCT
CAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAA
CGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCC
AGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCA
GCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCG
TCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCC
TTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTGCTTCAG
TGAGAATT

>25019_25019_6_EED-TPCN2_EED_chr11_85956385_ENST00000351625_TPCN2_chr11_68834971_ENST00000542467_length(amino acids)=366AA_BP=38
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV
FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR
SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC
VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLNFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHP
HLWLCR

--------------------------------------------------------------
>25019_25019_7_EED-TPCN2_EED_chr11_85956385_ENST00000528180_TPCN2_chr11_68834971_ENST00000294309_length(transcript)=2695nt_BP=591nt
ATTCCACAGACTTTCGCTCCCTAGCAGCGGGTCGGAGATCGAAGGAACGGGCCAATTGCGGCTGAAACGTCTTTGGAAGGAGGAAGGGGG
TGAGGGAGCATCCCTTTGAGTTTCGCCTCTTCTCGAGGCGGTGGTGGGAAGGGAGACATACTTAATACTGCCCTCTTAATCCAACGGACC
TTACATCGTGTAGACTGCCGGGAGGGCGGCGGGAAAAGGGCAAGACGGGAGTTGGGGAAGGGAAGGAGCCAGGAAGCCGCGCGGGAGGGC
GCGCGCGCGCGCCCCTTTTTCAGCAGTGTGGCGGGGTCGCACGCACGCCCGCCTCGGCGGCTGGGCGCGATTTGCGACAGTGGGGGGGGC
GGTGGAGGTGGCGGCGGCAGCGGCAACTTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGGCGGTGTGGCGGAGGCCCCGCCCCAGGCGG
CAGGAACCTGGAGGGAGGCGGAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAG
AAGCTGAGCAGTGACGAGAACAGCAATCCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTC
CAGAACCTGCCTGAGTCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAAC
CGGGCCTATGCCATCTTCTTCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTC
CGGGGCTACCTGATGAAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTG
GGGGAGGGAGGAGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCAC
AAACAGGCCATGATGGAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGA
AGTGTGGTTAAAGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGAC
TACCTGGGGAACCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGAT
GACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGG
TACCTGTCCTACCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTG
CCACACCCAGGCTGGAGGCCGGAGATGGTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTC
CTGCGTATCATCCCCAGCATGAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATC
CTGGTGGTGGTCTACTACGTATTTGCCATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCC
CCTGCCAATGGCTCGGCGCCCTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACT
CTGTGGAACTTGATGGTGGTGAACAACTGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTA
TTGTGGTGGCTGGTGTCGTCTGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGC
CACCTGCAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAG
GATGAGCTCACAGAGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGA
GAGAGGCTGGCCTACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCA
CTAAGCTGGGGACAGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCC
TCCGCTTTCTTTTATAGCTGCTTCAGTGAGAATTCCCTCGTCGACTCCACAGGGACCTTTCAGACAAAAATGCAAGAAGCAGCGGCCTCC
CCTGTCCCCTGCAGCTTCCGTGGTGCCTTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCTGACCAGGGCCTGCACAGGTTAACCGTCAG
ACTTCCGGGGCATTCAGGTGGGGATGCTGGTGGTTTGACATGGAGAGAACCTTGACTGTGTTTTATTATTTCATGGCTTGTATGAGTGTG
ACTGGGTGTGTTTCTTTAGGGTTCTGATTGCCAGTTATTTTCATCAATAAGTCTTGCAAAGAATGGGATTGTCATTCTTCACTTC

>25019_25019_7_EED-TPCN2_EED_chr11_85956385_ENST00000528180_TPCN2_chr11_68834971_ENST00000294309_length(amino acids)=672AA_BP=71
MSFASSRGGGGKGDILNTALLIQRTLHRVDCREGGGKRARRELGKGRSQEAAREGARARPFFSSVAGSHARPPRRLGAICDSGGGGGGGG
GSGNFAASSGRACLTAVWRRPRPRRQEPGGRRRNMSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPE
SLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGA
FPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNL
IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW
RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGS
APCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPL
AGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPHLWLCR

--------------------------------------------------------------
>25019_25019_8_EED-TPCN2_EED_chr11_85956385_ENST00000528180_TPCN2_chr11_68834971_ENST00000542467_length(transcript)=1828nt_BP=591nt
ATTCCACAGACTTTCGCTCCCTAGCAGCGGGTCGGAGATCGAAGGAACGGGCCAATTGCGGCTGAAACGTCTTTGGAAGGAGGAAGGGGG
TGAGGGAGCATCCCTTTGAGTTTCGCCTCTTCTCGAGGCGGTGGTGGGAAGGGAGACATACTTAATACTGCCCTCTTAATCCAACGGACC
TTACATCGTGTAGACTGCCGGGAGGGCGGCGGGAAAAGGGCAAGACGGGAGTTGGGGAAGGGAAGGAGCCAGGAAGCCGCGCGGGAGGGC
GCGCGCGCGCGCCCCTTTTTCAGCAGTGTGGCGGGGTCGCACGCACGCCCGCCTCGGCGGCTGGGCGCGATTTGCGACAGTGGGGGGGGC
GGTGGAGGTGGCGGCGGCAGCGGCAACTTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGGCGGTGTGGCGGAGGCCCCGCCCCAGGCGG
CAGGAACCTGGAGGGAGGCGGAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAG
AAGCTGAGCAGTGACGAGAACAGCAATCCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTC
CAGAACCTGCCTGAGTCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAAC
CGGGCCTATGCCATCTTCTTCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTC
CGGGGCTACCTGATGAAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTG
GGGGAGGGAGGAGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCAC
AAACAGGCCATGATGGAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGA
AGTGTGGTTAAAGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGAC
TACCTGGGGAACCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGAT
GACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGG
TACCTGTCCTACCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTG
CAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAG
CTCACAGAGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGG
CTGGCCTACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGC
TGGGGACAGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCT
TTCTTTTATAGCTGCTTCAGTGAGAATT

>25019_25019_8_EED-TPCN2_EED_chr11_85956385_ENST00000528180_TPCN2_chr11_68834971_ENST00000542467_length(amino acids)=490AA_BP=71
MSFASSRGGGGKGDILNTALLIQRTLHRVDCREGGGKRARRELGKGRSQEAAREGARARPFFSSVAGSHARPPRRLGAICDSGGGGGGGG
GSGNFAASSGRACLTAVWRRPRPRRQEPGGRRRNMSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPE
SLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGA
FPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNL
IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLNFLHKWDPRSHLQPLAG
TPEATYQMTVELLFRDILEEPGEDELTERLSQHPHLWLCR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EED-TPCN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+11281_44138.0442.0EZH2
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+11181_44138.0401.0EZH2
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+11381_44138.0467.0EZH2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EED-TPCN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EED-TPCN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEEDC4479654COHEN-GIBSON SYNDROME5GENOMICS_ENGLAND;UNIPROT
HgeneEEDC0027809Neurilemmoma1CTD_human
HgeneEEDC0206727Nerve Sheath Tumors1CTD_human
HgeneEEDC0265210Weaver syndrome1ORPHANET
HgeneEEDC0751374Schwannomatosis, Plexiform1CTD_human
HgeneEEDC0751689Peripheral Nerve Sheath Neoplasm1CTD_human
HgeneEEDC0751691Perineurioma1CTD_human