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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAM23-PPAP2A (FusionGDB2 ID:HG8745TG8611)

Fusion Gene Summary for ADAM23-PPAP2A

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM23-PPAP2A
Fusion gene ID: hg8745tg8611
HgeneTgene
Gene symbol

ADAM23

PPAP2A

Gene ID

8745

8611

Gene nameADAM metallopeptidase domain 23phospholipid phosphatase 1
SynonymsMDC-3|MDC3LLP1a|LPP1|PAP-2a|PAP2|PPAP2A
Cytomap('ADAM23')('PPAP2A')

2q33.3

5q11.2

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 23metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3phospholipid phosphatase 1lipid phosphate phosphohydrolase 1aphosphatidate phosphohydrolase type 2aphosphatidic acid phosphatase 2aphosphatidic acid phosphatase type 2Aphosphatidic acid phosphohydrolase type 2atype-2 phosphatidic acid phosphatase al
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264377, ENST00000374415, 
ENST00000374416, 
Fusion gene scores* DoF score4 X 4 X 3=4810 X 5 X 6=300
# samples 510
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAM23 [Title/Abstract] AND PPAP2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAM23(207432046)-PPAP2A(54721162), # samples:1
Anticipated loss of major functional domain due to fusion event.ADAM23-PPAP2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAM23-PPAP2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAM23-PPAP2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAM23-PPAP2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPAP2A

GO:0006644

phospholipid metabolic process

9305923|9705349|15461590

TgenePPAP2A

GO:0006670

sphingosine metabolic process

9705349

TgenePPAP2A

GO:0006672

ceramide metabolic process

9305923|9705349

TgenePPAP2A

GO:0046839

phospholipid dephosphorylation

9305923|9705349|15461590|16464866


check buttonFusion gene breakpoints across ADAM23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PPAP2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CR-7397-01AADAM23chr2

207432046

-PPAP2Achr5

54721162

-


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Fusion Gene ORF analysis for ADAM23-PPAP2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264377ENST00000515132ADAM23chr2

207432046

-PPAP2Achr5

54721162

-
5CDS-intronENST00000374415ENST00000515132ADAM23chr2

207432046

-PPAP2Achr5

54721162

-
5CDS-intronENST00000374416ENST00000515132ADAM23chr2

207432046

-PPAP2Achr5

54721162

-
In-frameENST00000264377ENST00000264775ADAM23chr2

207432046

-PPAP2Achr5

54721162

-
In-frameENST00000264377ENST00000307259ADAM23chr2

207432046

-PPAP2Achr5

54721162

-
In-frameENST00000374415ENST00000264775ADAM23chr2

207432046

-PPAP2Achr5

54721162

-
In-frameENST00000374415ENST00000307259ADAM23chr2

207432046

-PPAP2Achr5

54721162

-
In-frameENST00000374416ENST00000264775ADAM23chr2

207432046

-PPAP2Achr5

54721162

-
In-frameENST00000374416ENST00000307259ADAM23chr2

207432046

-PPAP2Achr5

54721162

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000264377ADAM23chr2207432046-ENST00000264775PPAP2Achr554721162-230318223281950540
ENST00000264377ADAM23chr2207432046-ENST00000307259PPAP2Achr554721162-227218223281950540
ENST00000374416ADAM23chr2207432046-ENST00000264775PPAP2Achr554721162-20271546521674540
ENST00000374416ADAM23chr2207432046-ENST00000307259PPAP2Achr554721162-19961546521674540
ENST00000374415ADAM23chr2207432046-ENST00000264775PPAP2Achr554721162-1975149401622540
ENST00000374415ADAM23chr2207432046-ENST00000307259PPAP2Achr554721162-1944149401622540

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264377ENST00000264775ADAM23chr2207432046-PPAP2Achr554721162-0.011163710.98883635
ENST00000264377ENST00000307259ADAM23chr2207432046-PPAP2Achr554721162-0.012026690.98797333
ENST00000374416ENST00000264775ADAM23chr2207432046-PPAP2Achr554721162-0.0062326060.9937674
ENST00000374416ENST00000307259ADAM23chr2207432046-PPAP2Achr554721162-0.006610480.9933895
ENST00000374415ENST00000264775ADAM23chr2207432046-PPAP2Achr554721162-0.0059839680.99401605
ENST00000374415ENST00000307259ADAM23chr2207432046-PPAP2Achr554721162-0.0063415050.9936585

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Fusion Genomic Features for ADAM23-PPAP2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ADAM23-PPAP2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:207432046/chr5:54721162)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAM23chr2:207432046chr5:54721162ENST00000264377-1526299_496498833.0DomainPeptidase M12B
HgeneADAM23chr2:207432046chr5:54721162ENST00000374416-1525299_496498833.0DomainPeptidase M12B
TgenePPAP2Achr2:207432046chr5:54721162ENST0000026477546251_284243286.0Topological domainCytoplasmic
TgenePPAP2Achr2:207432046chr5:54721162ENST0000030725946251_284242285.0Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAM23chr2:207432046chr5:54721162ENST00000264377-1526589_611498833.0Compositional biasNote=Cys-rich
HgeneADAM23chr2:207432046chr5:54721162ENST00000374416-1525589_611498833.0Compositional biasNote=Cys-rich
HgeneADAM23chr2:207432046chr5:54721162ENST00000264377-1526502_588498833.0DomainDisintegrin
HgeneADAM23chr2:207432046chr5:54721162ENST00000264377-1526732_769498833.0DomainEGF-like
HgeneADAM23chr2:207432046chr5:54721162ENST00000374416-1525502_588498833.0DomainDisintegrin
HgeneADAM23chr2:207432046chr5:54721162ENST00000374416-1525732_769498833.0DomainEGF-like
HgeneADAM23chr2:207432046chr5:54721162ENST00000264377-1526563_568498833.0RegionNote=May bind the integrin receptor
HgeneADAM23chr2:207432046chr5:54721162ENST00000374416-1525563_568498833.0RegionNote=May bind the integrin receptor
HgeneADAM23chr2:207432046chr5:54721162ENST00000264377-1526287_792498833.0Topological domainExtracellular
HgeneADAM23chr2:207432046chr5:54721162ENST00000264377-1526814_832498833.0Topological domainCytoplasmic
HgeneADAM23chr2:207432046chr5:54721162ENST00000374416-1525287_792498833.0Topological domainExtracellular
HgeneADAM23chr2:207432046chr5:54721162ENST00000374416-1525814_832498833.0Topological domainCytoplasmic
HgeneADAM23chr2:207432046chr5:54721162ENST00000264377-1526793_813498833.0TransmembraneHelical
HgeneADAM23chr2:207432046chr5:54721162ENST00000374416-1525793_813498833.0TransmembraneHelical
TgenePPAP2Achr2:207432046chr5:54721162ENST00000264775465_7243286.0MotifPDZ-binding%3B involved in localization to the apical cell membrane
TgenePPAP2Achr2:207432046chr5:54721162ENST00000307259465_7242285.0MotifPDZ-binding%3B involved in localization to the apical cell membrane
TgenePPAP2Achr2:207432046chr5:54721162ENST0000026477546120_128243286.0RegionPhosphatase sequence motif I
TgenePPAP2Achr2:207432046chr5:54721162ENST0000026477546168_171243286.0RegionPhosphatase sequence motif II
TgenePPAP2Achr2:207432046chr5:54721162ENST0000026477546216_227243286.0RegionPhosphatase sequence motif III
TgenePPAP2Achr2:207432046chr5:54721162ENST0000030725946120_128242285.0RegionPhosphatase sequence motif I
TgenePPAP2Achr2:207432046chr5:54721162ENST0000030725946168_171242285.0RegionPhosphatase sequence motif II
TgenePPAP2Achr2:207432046chr5:54721162ENST0000030725946216_227242285.0RegionPhosphatase sequence motif III
TgenePPAP2Achr2:207432046chr5:54721162ENST0000026477546116_164243286.0Topological domainExtracellular
TgenePPAP2Achr2:207432046chr5:54721162ENST0000026477546186_199243286.0Topological domainCytoplasmic
TgenePPAP2Achr2:207432046chr5:54721162ENST00000264775461_6243286.0Topological domainCytoplasmic
TgenePPAP2Achr2:207432046chr5:54721162ENST0000026477546221_229243286.0Topological domainExtracellular
TgenePPAP2Achr2:207432046chr5:54721162ENST000002647754628_53243286.0Topological domainExtracellular
TgenePPAP2Achr2:207432046chr5:54721162ENST000002647754675_94243286.0Topological domainCytoplasmic
TgenePPAP2Achr2:207432046chr5:54721162ENST0000030725946116_164242285.0Topological domainExtracellular
TgenePPAP2Achr2:207432046chr5:54721162ENST0000030725946186_199242285.0Topological domainCytoplasmic
TgenePPAP2Achr2:207432046chr5:54721162ENST00000307259461_6242285.0Topological domainCytoplasmic
TgenePPAP2Achr2:207432046chr5:54721162ENST0000030725946221_229242285.0Topological domainExtracellular
TgenePPAP2Achr2:207432046chr5:54721162ENST000003072594628_53242285.0Topological domainExtracellular
TgenePPAP2Achr2:207432046chr5:54721162ENST000003072594675_94242285.0Topological domainCytoplasmic
TgenePPAP2Achr2:207432046chr5:54721162ENST0000026477546165_185243286.0TransmembraneHelical
TgenePPAP2Achr2:207432046chr5:54721162ENST0000026477546200_220243286.0TransmembraneHelical
TgenePPAP2Achr2:207432046chr5:54721162ENST0000026477546230_250243286.0TransmembraneHelical
TgenePPAP2Achr2:207432046chr5:54721162ENST000002647754654_74243286.0TransmembraneHelical
TgenePPAP2Achr2:207432046chr5:54721162ENST00000264775467_27243286.0TransmembraneHelical
TgenePPAP2Achr2:207432046chr5:54721162ENST000002647754695_115243286.0TransmembraneHelical
TgenePPAP2Achr2:207432046chr5:54721162ENST0000030725946165_185242285.0TransmembraneHelical
TgenePPAP2Achr2:207432046chr5:54721162ENST0000030725946200_220242285.0TransmembraneHelical
TgenePPAP2Achr2:207432046chr5:54721162ENST0000030725946230_250242285.0TransmembraneHelical
TgenePPAP2Achr2:207432046chr5:54721162ENST000003072594654_74242285.0TransmembraneHelical
TgenePPAP2Achr2:207432046chr5:54721162ENST00000307259467_27242285.0TransmembraneHelical
TgenePPAP2Achr2:207432046chr5:54721162ENST000003072594695_115242285.0TransmembraneHelical


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Fusion Gene Sequence for ADAM23-PPAP2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1997_1997_1_ADAM23-PPAP2A_ADAM23_chr2_207432046_ENST00000264377_PPAP2A_chr5_54721162_ENST00000264775_length(transcript)=2303nt_BP=1822nt
GGCCCGGCGGCAGCCCCCGCAGTCGCTGAAGCGGCCGCGCCCGCCGGGGGAGGGAGTAGCCGCTGGGGAGGCTCCAAGTTGGCGGAGCGG
CGAGGACCCCTGGACTCCTCTGCGTCCCGCCCCGGGAGTGGCTGCGAGGCTAGGCGAGCCGGGAAAGGGGGCGCCGCCCAGCCCCGAGCC
CCGCGCCCCGTGCCCCGAGCCCGGAGCCCCCTGCCCGCCGCGGCACCATGCGCGCCGAGCCGGCGTGACCGGCTCCGCCCGCGGCCGCCC
CGCAGCTAGCCCGGCGCTCTCGCCGGCCACACGGAGCGGCGCCCGGGAGCTATGAGCCATGAAGCCGCCCGGCAGCAGCTCGCGGCAGCC
GCCCCTGGCGGGCTGCAGCCTTGCCGGCGCTTCCTGCGGCCCCCAACGCGGCCCCGCCGGCTCGGTGCCTGCCAGCGCCCCGGCCCGCAC
GCCGCCCTGCCGCCTGCTTCTCGTCCTTCTCCTGCTGCCTCCGCTCGCCGCCTCGTCCCGGCCCCGCGCCTGGGGGGCTGCTGCGCCCAG
CGCTCCGCATTGGAATGAAACTGCAGAAAAAAATTTGGGAGTCCTGGCAGATGAAGACAATACATTGCAACAGAATAGCAGCAGTAATAT
CAGTTACAGCAATGCAATGCAGAAAGAAATCACACTGCCTTCAAGACTCATATATTACATCAACCAAGACTCGGAAAGCCCTTATCACGT
TCTTGACACAAAGGCAAGACACCAGCAAAAACATAATAAGGCTGTCCATCTGGCCCAGGCAAGCTTCCAGATTGAAGCCTTCGGCTCCAA
ATTCATTCTTGACCTCATACTGAACAATGGTTTGTTGTCTTCTGATTATGTGGAGATTCACTACGAAAATGGGAAACCACAGTACTCTAA
GGGTGGAGAGCACTGTTACTACCATGGAAGCATCAGAGGCGTCAAAGACTCCAAGGTGGCTCTGTCAACCTGCAATGGACTTCATGGCAT
GTTTGAAGATGATACCTTCGTGTATATGATAGAGCCACTAGAGCTGGTTCATGATGAGAAAAGCACAGGTCGACCACATATAATCCAGAA
AACCTTGGCAGGACAGTATTCTAAGCAAATGAAGAATCTCACTATGGAAAGAGGTGACCAGTGGCCCTTTCTCTCTGAATTACAGTGGTT
GAAAAGAAGGAAGAGAGCAGTGAATCCATCACGTGGTATATTTGAAGAAATGAAATATTTGGAACTTATGATTGTTAATGATCACAAAAC
GTATAAGAAGCATCGCTCTTCTCATGCACATACCAACAACTTTGCAAAGTCCGTGGTCAACCTTGTGGATTCTATTTACAAGGAGCAGCT
CAACACCAGGGTTGTCCTGGTGGCTGTAGAGACCTGGACTGAGAAGGATCAGATTGACATCACCACCAACCCTGTGCAGATGCTCCATGA
GTTCTCAAAATACCGGCAGCGCATTAAGCAGCATGCTGATGCTGTGCACCTCATCTCGCGGGTGACATTTCACTATAAGAGAAGCAGTCT
GAGTTACTTTGGAGGTGTCTGTTCTCGCACAAGAGGAGTTGGTGTGAATGAGTATGGTCTTCCAATGGCAGTGGCACAAGTATTATCGCA
GAGCCTGGCTCAAAACCTTGGAATCCAATGGGAACCTTCTAGCAGAAAGCCAAAATGTGACTGCACAGAATCCTGGGGTGGCTGCATCAT
GGAGGAAACAGGGGTGTCCCATTCTCGAAAATTTTCAAAGTGCAGCATTTTGGAGTATAGAGACTTTTTACAGAGAGGAGGTGGAGCCTG
CCTTTTCAACAGGCCAACAAAGGCTGTATATGTATCGGATTTCTTCAAAGAAAGAACTTCTTTTAAAGAAAGAAAAGAGGAGGACTCTCA
TACAACTCTGCATGAAACACCAACAACTGGGAATCACTATCCGAGCAATCACCAGCCTTGAAAGGCAGCAGGGTGCCCAGGTGAAGCTGG
CCTGTTTTCTAAAGGAAAATGATTGCCACAAGGCAAGAGGATGCATCTTTCTTCCTGGTGTACAAGCCTTTAAAGACTTCTGCTGCTGCT
ATGCCTCTTGGATGCACACTTTGTGTGTACATAGTTACCTTTAACTCAGTGGTTATCTAATAGCTCTAAACTCATTAAAAAAACTCCAAG
CCTTCCACCAAAACAGTGCCCCACCTGTATACATTTTTATTAAAAAAATGTAATGCTTATGTATAAACATGTATGTAATATGCTTTCTAT

>1997_1997_1_ADAM23-PPAP2A_ADAM23_chr2_207432046_ENST00000264377_PPAP2A_chr5_54721162_ENST00000264775_length(amino acids)=540AA_BP=498
MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASSRPRAWGAAAPSAPHWNETAEKNLGVLADED
NTLQQNSSSNISYSNAMQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEI
HYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERGD
QWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQID
ITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKC
DCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGNHYPSNHQP

--------------------------------------------------------------
>1997_1997_2_ADAM23-PPAP2A_ADAM23_chr2_207432046_ENST00000264377_PPAP2A_chr5_54721162_ENST00000307259_length(transcript)=2272nt_BP=1822nt
GGCCCGGCGGCAGCCCCCGCAGTCGCTGAAGCGGCCGCGCCCGCCGGGGGAGGGAGTAGCCGCTGGGGAGGCTCCAAGTTGGCGGAGCGG
CGAGGACCCCTGGACTCCTCTGCGTCCCGCCCCGGGAGTGGCTGCGAGGCTAGGCGAGCCGGGAAAGGGGGCGCCGCCCAGCCCCGAGCC
CCGCGCCCCGTGCCCCGAGCCCGGAGCCCCCTGCCCGCCGCGGCACCATGCGCGCCGAGCCGGCGTGACCGGCTCCGCCCGCGGCCGCCC
CGCAGCTAGCCCGGCGCTCTCGCCGGCCACACGGAGCGGCGCCCGGGAGCTATGAGCCATGAAGCCGCCCGGCAGCAGCTCGCGGCAGCC
GCCCCTGGCGGGCTGCAGCCTTGCCGGCGCTTCCTGCGGCCCCCAACGCGGCCCCGCCGGCTCGGTGCCTGCCAGCGCCCCGGCCCGCAC
GCCGCCCTGCCGCCTGCTTCTCGTCCTTCTCCTGCTGCCTCCGCTCGCCGCCTCGTCCCGGCCCCGCGCCTGGGGGGCTGCTGCGCCCAG
CGCTCCGCATTGGAATGAAACTGCAGAAAAAAATTTGGGAGTCCTGGCAGATGAAGACAATACATTGCAACAGAATAGCAGCAGTAATAT
CAGTTACAGCAATGCAATGCAGAAAGAAATCACACTGCCTTCAAGACTCATATATTACATCAACCAAGACTCGGAAAGCCCTTATCACGT
TCTTGACACAAAGGCAAGACACCAGCAAAAACATAATAAGGCTGTCCATCTGGCCCAGGCAAGCTTCCAGATTGAAGCCTTCGGCTCCAA
ATTCATTCTTGACCTCATACTGAACAATGGTTTGTTGTCTTCTGATTATGTGGAGATTCACTACGAAAATGGGAAACCACAGTACTCTAA
GGGTGGAGAGCACTGTTACTACCATGGAAGCATCAGAGGCGTCAAAGACTCCAAGGTGGCTCTGTCAACCTGCAATGGACTTCATGGCAT
GTTTGAAGATGATACCTTCGTGTATATGATAGAGCCACTAGAGCTGGTTCATGATGAGAAAAGCACAGGTCGACCACATATAATCCAGAA
AACCTTGGCAGGACAGTATTCTAAGCAAATGAAGAATCTCACTATGGAAAGAGGTGACCAGTGGCCCTTTCTCTCTGAATTACAGTGGTT
GAAAAGAAGGAAGAGAGCAGTGAATCCATCACGTGGTATATTTGAAGAAATGAAATATTTGGAACTTATGATTGTTAATGATCACAAAAC
GTATAAGAAGCATCGCTCTTCTCATGCACATACCAACAACTTTGCAAAGTCCGTGGTCAACCTTGTGGATTCTATTTACAAGGAGCAGCT
CAACACCAGGGTTGTCCTGGTGGCTGTAGAGACCTGGACTGAGAAGGATCAGATTGACATCACCACCAACCCTGTGCAGATGCTCCATGA
GTTCTCAAAATACCGGCAGCGCATTAAGCAGCATGCTGATGCTGTGCACCTCATCTCGCGGGTGACATTTCACTATAAGAGAAGCAGTCT
GAGTTACTTTGGAGGTGTCTGTTCTCGCACAAGAGGAGTTGGTGTGAATGAGTATGGTCTTCCAATGGCAGTGGCACAAGTATTATCGCA
GAGCCTGGCTCAAAACCTTGGAATCCAATGGGAACCTTCTAGCAGAAAGCCAAAATGTGACTGCACAGAATCCTGGGGTGGCTGCATCAT
GGAGGAAACAGGGGTGTCCCATTCTCGAAAATTTTCAAAGTGCAGCATTTTGGAGTATAGAGACTTTTTACAGAGAGGAGGTGGAGCCTG
CCTTTTCAACAGGCCAACAAAGGCTGTATATGTATCGGATTTCTTCAAAGAAAGAACTTCTTTTAAAGAAAGAAAAGAGGAGGACTCTCA
TACAACTCTGCATGAAACACCAACAACTGGGAATCACTATCCGAGCAATCACCAGCCTTGAAAGGCAGCAGGGTGCCCAGGTGAAGCTGG
CCTGTTTTCTAAAGGAAAATGATTGCCACAAGGCAAGAGGATGCATCTTTCTTCCTGGTGTACAAGCCTTTAAAGACTTCTGCTGCTGCT
ATGCCTCTTGGATGCACACTTTGTGTGTACATAGTTACCTTTAACTCAGTGGTTATCTAATAGCTCTAAACTCATTAAAAAAACTCCAAG
CCTTCCACCAAAACAGTGCCCCACCTGTATACATTTTTATTAAAAAAATGTAATGCTTATGTATAAACATGTATGTAATATGCTTTCTAT

>1997_1997_2_ADAM23-PPAP2A_ADAM23_chr2_207432046_ENST00000264377_PPAP2A_chr5_54721162_ENST00000307259_length(amino acids)=540AA_BP=498
MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASSRPRAWGAAAPSAPHWNETAEKNLGVLADED
NTLQQNSSSNISYSNAMQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEI
HYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERGD
QWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQID
ITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKC
DCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGNHYPSNHQP

--------------------------------------------------------------
>1997_1997_3_ADAM23-PPAP2A_ADAM23_chr2_207432046_ENST00000374415_PPAP2A_chr5_54721162_ENST00000264775_length(transcript)=1975nt_BP=1494nt
ATGAAGCCGCCCGGCAGCAGCTCGCGGCAGCCGCCCCTGGCGGGCTGCAGCCTTGCCGGCGCTTCCTGCGGCCCCCAACGCGGCCCCGCC
GGCTCGGTGCCTGCCAGCGCCCCGGCCCGCACGCCGCCCTGCCGCCTGCTTCTCGTCCTTCTCCTGCTGCCTCCGCTCGCCGCCTCGTCC
CGGCCCCGCGCCTGGGGGGCTGCTGCGCCCAGCGCTCCGCATTGGAATGAAACTGCAGAAAAAAATTTGGGAGTCCTGGCAGATGAAGAC
AATACATTGCAACAGAATAGCAGCAGTAATATCAGTTACAGCAATGCAATGCAGAAAGAAATCACACTGCCTTCAAGACTCATATATTAC
ATCAACCAAGACTCGGAAAGCCCTTATCACGTTCTTGACACAAAGGCAAGACACCAGCAAAAACATAATAAGGCTGTCCATCTGGCCCAG
GCAAGCTTCCAGATTGAAGCCTTCGGCTCCAAATTCATTCTTGACCTCATACTGAACAATGGTTTGTTGTCTTCTGATTATGTGGAGATT
CACTACGAAAATGGGAAACCACAGTACTCTAAGGGTGGAGAGCACTGTTACTACCATGGAAGCATCAGAGGCGTCAAAGACTCCAAGGTG
GCTCTGTCAACCTGCAATGGACTTCATGGCATGTTTGAAGATGATACCTTCGTGTATATGATAGAGCCACTAGAGCTGGTTCATGATGAG
AAAAGCACAGGTCGACCACATATAATCCAGAAAACCTTGGCAGGACAGTATTCTAAGCAAATGAAGAATCTCACTATGGAAAGAGGTGAC
CAGTGGCCCTTTCTCTCTGAATTACAGTGGTTGAAAAGAAGGAAGAGAGCAGTGAATCCATCACGTGGTATATTTGAAGAAATGAAATAT
TTGGAACTTATGATTGTTAATGATCACAAAACGTATAAGAAGCATCGCTCTTCTCATGCACATACCAACAACTTTGCAAAGTCCGTGGTC
AACCTTGTGGATTCTATTTACAAGGAGCAGCTCAACACCAGGGTTGTCCTGGTGGCTGTAGAGACCTGGACTGAGAAGGATCAGATTGAC
ATCACCACCAACCCTGTGCAGATGCTCCATGAGTTCTCAAAATACCGGCAGCGCATTAAGCAGCATGCTGATGCTGTGCACCTCATCTCG
CGGGTGACATTTCACTATAAGAGAAGCAGTCTGAGTTACTTTGGAGGTGTCTGTTCTCGCACAAGAGGAGTTGGTGTGAATGAGTATGGT
CTTCCAATGGCAGTGGCACAAGTATTATCGCAGAGCCTGGCTCAAAACCTTGGAATCCAATGGGAACCTTCTAGCAGAAAGCCAAAATGT
GACTGCACAGAATCCTGGGGTGGCTGCATCATGGAGGAAACAGGGGTGTCCCATTCTCGAAAATTTTCAAAGTGCAGCATTTTGGAGTAT
AGAGACTTTTTACAGAGAGGAGGTGGAGCCTGCCTTTTCAACAGGCCAACAAAGGCTGTATATGTATCGGATTTCTTCAAAGAAAGAACT
TCTTTTAAAGAAAGAAAAGAGGAGGACTCTCATACAACTCTGCATGAAACACCAACAACTGGGAATCACTATCCGAGCAATCACCAGCCT
TGAAAGGCAGCAGGGTGCCCAGGTGAAGCTGGCCTGTTTTCTAAAGGAAAATGATTGCCACAAGGCAAGAGGATGCATCTTTCTTCCTGG
TGTACAAGCCTTTAAAGACTTCTGCTGCTGCTATGCCTCTTGGATGCACACTTTGTGTGTACATAGTTACCTTTAACTCAGTGGTTATCT
AATAGCTCTAAACTCATTAAAAAAACTCCAAGCCTTCCACCAAAACAGTGCCCCACCTGTATACATTTTTATTAAAAAAATGTAATGCTT

>1997_1997_3_ADAM23-PPAP2A_ADAM23_chr2_207432046_ENST00000374415_PPAP2A_chr5_54721162_ENST00000264775_length(amino acids)=540AA_BP=498
MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASSRPRAWGAAAPSAPHWNETAEKNLGVLADED
NTLQQNSSSNISYSNAMQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEI
HYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERGD
QWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQID
ITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKC
DCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGNHYPSNHQP

--------------------------------------------------------------
>1997_1997_4_ADAM23-PPAP2A_ADAM23_chr2_207432046_ENST00000374415_PPAP2A_chr5_54721162_ENST00000307259_length(transcript)=1944nt_BP=1494nt
ATGAAGCCGCCCGGCAGCAGCTCGCGGCAGCCGCCCCTGGCGGGCTGCAGCCTTGCCGGCGCTTCCTGCGGCCCCCAACGCGGCCCCGCC
GGCTCGGTGCCTGCCAGCGCCCCGGCCCGCACGCCGCCCTGCCGCCTGCTTCTCGTCCTTCTCCTGCTGCCTCCGCTCGCCGCCTCGTCC
CGGCCCCGCGCCTGGGGGGCTGCTGCGCCCAGCGCTCCGCATTGGAATGAAACTGCAGAAAAAAATTTGGGAGTCCTGGCAGATGAAGAC
AATACATTGCAACAGAATAGCAGCAGTAATATCAGTTACAGCAATGCAATGCAGAAAGAAATCACACTGCCTTCAAGACTCATATATTAC
ATCAACCAAGACTCGGAAAGCCCTTATCACGTTCTTGACACAAAGGCAAGACACCAGCAAAAACATAATAAGGCTGTCCATCTGGCCCAG
GCAAGCTTCCAGATTGAAGCCTTCGGCTCCAAATTCATTCTTGACCTCATACTGAACAATGGTTTGTTGTCTTCTGATTATGTGGAGATT
CACTACGAAAATGGGAAACCACAGTACTCTAAGGGTGGAGAGCACTGTTACTACCATGGAAGCATCAGAGGCGTCAAAGACTCCAAGGTG
GCTCTGTCAACCTGCAATGGACTTCATGGCATGTTTGAAGATGATACCTTCGTGTATATGATAGAGCCACTAGAGCTGGTTCATGATGAG
AAAAGCACAGGTCGACCACATATAATCCAGAAAACCTTGGCAGGACAGTATTCTAAGCAAATGAAGAATCTCACTATGGAAAGAGGTGAC
CAGTGGCCCTTTCTCTCTGAATTACAGTGGTTGAAAAGAAGGAAGAGAGCAGTGAATCCATCACGTGGTATATTTGAAGAAATGAAATAT
TTGGAACTTATGATTGTTAATGATCACAAAACGTATAAGAAGCATCGCTCTTCTCATGCACATACCAACAACTTTGCAAAGTCCGTGGTC
AACCTTGTGGATTCTATTTACAAGGAGCAGCTCAACACCAGGGTTGTCCTGGTGGCTGTAGAGACCTGGACTGAGAAGGATCAGATTGAC
ATCACCACCAACCCTGTGCAGATGCTCCATGAGTTCTCAAAATACCGGCAGCGCATTAAGCAGCATGCTGATGCTGTGCACCTCATCTCG
CGGGTGACATTTCACTATAAGAGAAGCAGTCTGAGTTACTTTGGAGGTGTCTGTTCTCGCACAAGAGGAGTTGGTGTGAATGAGTATGGT
CTTCCAATGGCAGTGGCACAAGTATTATCGCAGAGCCTGGCTCAAAACCTTGGAATCCAATGGGAACCTTCTAGCAGAAAGCCAAAATGT
GACTGCACAGAATCCTGGGGTGGCTGCATCATGGAGGAAACAGGGGTGTCCCATTCTCGAAAATTTTCAAAGTGCAGCATTTTGGAGTAT
AGAGACTTTTTACAGAGAGGAGGTGGAGCCTGCCTTTTCAACAGGCCAACAAAGGCTGTATATGTATCGGATTTCTTCAAAGAAAGAACT
TCTTTTAAAGAAAGAAAAGAGGAGGACTCTCATACAACTCTGCATGAAACACCAACAACTGGGAATCACTATCCGAGCAATCACCAGCCT
TGAAAGGCAGCAGGGTGCCCAGGTGAAGCTGGCCTGTTTTCTAAAGGAAAATGATTGCCACAAGGCAAGAGGATGCATCTTTCTTCCTGG
TGTACAAGCCTTTAAAGACTTCTGCTGCTGCTATGCCTCTTGGATGCACACTTTGTGTGTACATAGTTACCTTTAACTCAGTGGTTATCT
AATAGCTCTAAACTCATTAAAAAAACTCCAAGCCTTCCACCAAAACAGTGCCCCACCTGTATACATTTTTATTAAAAAAATGTAATGCTT

>1997_1997_4_ADAM23-PPAP2A_ADAM23_chr2_207432046_ENST00000374415_PPAP2A_chr5_54721162_ENST00000307259_length(amino acids)=540AA_BP=498
MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASSRPRAWGAAAPSAPHWNETAEKNLGVLADED
NTLQQNSSSNISYSNAMQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEI
HYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERGD
QWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQID
ITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKC
DCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGNHYPSNHQP

--------------------------------------------------------------
>1997_1997_5_ADAM23-PPAP2A_ADAM23_chr2_207432046_ENST00000374416_PPAP2A_chr5_54721162_ENST00000264775_length(transcript)=2027nt_BP=1546nt
TAGCCCGGCGCTCTCGCCGGCCACACGGAGCGGCGCCCGGGAGCTATGAGCCATGAAGCCGCCCGGCAGCAGCTCGCGGCAGCCGCCCCT
GGCGGGCTGCAGCCTTGCCGGCGCTTCCTGCGGCCCCCAACGCGGCCCCGCCGGCTCGGTGCCTGCCAGCGCCCCGGCCCGCACGCCGCC
CTGCCGCCTGCTTCTCGTCCTTCTCCTGCTGCCTCCGCTCGCCGCCTCGTCCCGGCCCCGCGCCTGGGGGGCTGCTGCGCCCAGCGCTCC
GCATTGGAATGAAACTGCAGAAAAAAATTTGGGAGTCCTGGCAGATGAAGACAATACATTGCAACAGAATAGCAGCAGTAATATCAGTTA
CAGCAATGCAATGCAGAAAGAAATCACACTGCCTTCAAGACTCATATATTACATCAACCAAGACTCGGAAAGCCCTTATCACGTTCTTGA
CACAAAGGCAAGACACCAGCAAAAACATAATAAGGCTGTCCATCTGGCCCAGGCAAGCTTCCAGATTGAAGCCTTCGGCTCCAAATTCAT
TCTTGACCTCATACTGAACAATGGTTTGTTGTCTTCTGATTATGTGGAGATTCACTACGAAAATGGGAAACCACAGTACTCTAAGGGTGG
AGAGCACTGTTACTACCATGGAAGCATCAGAGGCGTCAAAGACTCCAAGGTGGCTCTGTCAACCTGCAATGGACTTCATGGCATGTTTGA
AGATGATACCTTCGTGTATATGATAGAGCCACTAGAGCTGGTTCATGATGAGAAAAGCACAGGTCGACCACATATAATCCAGAAAACCTT
GGCAGGACAGTATTCTAAGCAAATGAAGAATCTCACTATGGAAAGAGGTGACCAGTGGCCCTTTCTCTCTGAATTACAGTGGTTGAAAAG
AAGGAAGAGAGCAGTGAATCCATCACGTGGTATATTTGAAGAAATGAAATATTTGGAACTTATGATTGTTAATGATCACAAAACGTATAA
GAAGCATCGCTCTTCTCATGCACATACCAACAACTTTGCAAAGTCCGTGGTCAACCTTGTGGATTCTATTTACAAGGAGCAGCTCAACAC
CAGGGTTGTCCTGGTGGCTGTAGAGACCTGGACTGAGAAGGATCAGATTGACATCACCACCAACCCTGTGCAGATGCTCCATGAGTTCTC
AAAATACCGGCAGCGCATTAAGCAGCATGCTGATGCTGTGCACCTCATCTCGCGGGTGACATTTCACTATAAGAGAAGCAGTCTGAGTTA
CTTTGGAGGTGTCTGTTCTCGCACAAGAGGAGTTGGTGTGAATGAGTATGGTCTTCCAATGGCAGTGGCACAAGTATTATCGCAGAGCCT
GGCTCAAAACCTTGGAATCCAATGGGAACCTTCTAGCAGAAAGCCAAAATGTGACTGCACAGAATCCTGGGGTGGCTGCATCATGGAGGA
AACAGGGGTGTCCCATTCTCGAAAATTTTCAAAGTGCAGCATTTTGGAGTATAGAGACTTTTTACAGAGAGGAGGTGGAGCCTGCCTTTT
CAACAGGCCAACAAAGGCTGTATATGTATCGGATTTCTTCAAAGAAAGAACTTCTTTTAAAGAAAGAAAAGAGGAGGACTCTCATACAAC
TCTGCATGAAACACCAACAACTGGGAATCACTATCCGAGCAATCACCAGCCTTGAAAGGCAGCAGGGTGCCCAGGTGAAGCTGGCCTGTT
TTCTAAAGGAAAATGATTGCCACAAGGCAAGAGGATGCATCTTTCTTCCTGGTGTACAAGCCTTTAAAGACTTCTGCTGCTGCTATGCCT
CTTGGATGCACACTTTGTGTGTACATAGTTACCTTTAACTCAGTGGTTATCTAATAGCTCTAAACTCATTAAAAAAACTCCAAGCCTTCC
ACCAAAACAGTGCCCCACCTGTATACATTTTTATTAAAAAAATGTAATGCTTATGTATAAACATGTATGTAATATGCTTTCTATGAATGA

>1997_1997_5_ADAM23-PPAP2A_ADAM23_chr2_207432046_ENST00000374416_PPAP2A_chr5_54721162_ENST00000264775_length(amino acids)=540AA_BP=498
MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASSRPRAWGAAAPSAPHWNETAEKNLGVLADED
NTLQQNSSSNISYSNAMQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEI
HYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERGD
QWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQID
ITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKC
DCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGNHYPSNHQP

--------------------------------------------------------------
>1997_1997_6_ADAM23-PPAP2A_ADAM23_chr2_207432046_ENST00000374416_PPAP2A_chr5_54721162_ENST00000307259_length(transcript)=1996nt_BP=1546nt
TAGCCCGGCGCTCTCGCCGGCCACACGGAGCGGCGCCCGGGAGCTATGAGCCATGAAGCCGCCCGGCAGCAGCTCGCGGCAGCCGCCCCT
GGCGGGCTGCAGCCTTGCCGGCGCTTCCTGCGGCCCCCAACGCGGCCCCGCCGGCTCGGTGCCTGCCAGCGCCCCGGCCCGCACGCCGCC
CTGCCGCCTGCTTCTCGTCCTTCTCCTGCTGCCTCCGCTCGCCGCCTCGTCCCGGCCCCGCGCCTGGGGGGCTGCTGCGCCCAGCGCTCC
GCATTGGAATGAAACTGCAGAAAAAAATTTGGGAGTCCTGGCAGATGAAGACAATACATTGCAACAGAATAGCAGCAGTAATATCAGTTA
CAGCAATGCAATGCAGAAAGAAATCACACTGCCTTCAAGACTCATATATTACATCAACCAAGACTCGGAAAGCCCTTATCACGTTCTTGA
CACAAAGGCAAGACACCAGCAAAAACATAATAAGGCTGTCCATCTGGCCCAGGCAAGCTTCCAGATTGAAGCCTTCGGCTCCAAATTCAT
TCTTGACCTCATACTGAACAATGGTTTGTTGTCTTCTGATTATGTGGAGATTCACTACGAAAATGGGAAACCACAGTACTCTAAGGGTGG
AGAGCACTGTTACTACCATGGAAGCATCAGAGGCGTCAAAGACTCCAAGGTGGCTCTGTCAACCTGCAATGGACTTCATGGCATGTTTGA
AGATGATACCTTCGTGTATATGATAGAGCCACTAGAGCTGGTTCATGATGAGAAAAGCACAGGTCGACCACATATAATCCAGAAAACCTT
GGCAGGACAGTATTCTAAGCAAATGAAGAATCTCACTATGGAAAGAGGTGACCAGTGGCCCTTTCTCTCTGAATTACAGTGGTTGAAAAG
AAGGAAGAGAGCAGTGAATCCATCACGTGGTATATTTGAAGAAATGAAATATTTGGAACTTATGATTGTTAATGATCACAAAACGTATAA
GAAGCATCGCTCTTCTCATGCACATACCAACAACTTTGCAAAGTCCGTGGTCAACCTTGTGGATTCTATTTACAAGGAGCAGCTCAACAC
CAGGGTTGTCCTGGTGGCTGTAGAGACCTGGACTGAGAAGGATCAGATTGACATCACCACCAACCCTGTGCAGATGCTCCATGAGTTCTC
AAAATACCGGCAGCGCATTAAGCAGCATGCTGATGCTGTGCACCTCATCTCGCGGGTGACATTTCACTATAAGAGAAGCAGTCTGAGTTA
CTTTGGAGGTGTCTGTTCTCGCACAAGAGGAGTTGGTGTGAATGAGTATGGTCTTCCAATGGCAGTGGCACAAGTATTATCGCAGAGCCT
GGCTCAAAACCTTGGAATCCAATGGGAACCTTCTAGCAGAAAGCCAAAATGTGACTGCACAGAATCCTGGGGTGGCTGCATCATGGAGGA
AACAGGGGTGTCCCATTCTCGAAAATTTTCAAAGTGCAGCATTTTGGAGTATAGAGACTTTTTACAGAGAGGAGGTGGAGCCTGCCTTTT
CAACAGGCCAACAAAGGCTGTATATGTATCGGATTTCTTCAAAGAAAGAACTTCTTTTAAAGAAAGAAAAGAGGAGGACTCTCATACAAC
TCTGCATGAAACACCAACAACTGGGAATCACTATCCGAGCAATCACCAGCCTTGAAAGGCAGCAGGGTGCCCAGGTGAAGCTGGCCTGTT
TTCTAAAGGAAAATGATTGCCACAAGGCAAGAGGATGCATCTTTCTTCCTGGTGTACAAGCCTTTAAAGACTTCTGCTGCTGCTATGCCT
CTTGGATGCACACTTTGTGTGTACATAGTTACCTTTAACTCAGTGGTTATCTAATAGCTCTAAACTCATTAAAAAAACTCCAAGCCTTCC
ACCAAAACAGTGCCCCACCTGTATACATTTTTATTAAAAAAATGTAATGCTTATGTATAAACATGTATGTAATATGCTTTCTATGAATGA

>1997_1997_6_ADAM23-PPAP2A_ADAM23_chr2_207432046_ENST00000374416_PPAP2A_chr5_54721162_ENST00000307259_length(amino acids)=540AA_BP=498
MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASSRPRAWGAAAPSAPHWNETAEKNLGVLADED
NTLQQNSSSNISYSNAMQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEI
HYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERGD
QWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQID
ITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKC
DCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGNHYPSNHQP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADAM23-PPAP2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAM23-PPAP2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADAM23-PPAP2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource