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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACTN1-PHACTR4 (FusionGDB2 ID:HG87TG65979)

Fusion Gene Summary for ACTN1-PHACTR4

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTN1-PHACTR4
Fusion gene ID: hg87tg65979
HgeneTgene
Gene symbol

ACTN1

PHACTR4

Gene ID

87

65979

Gene nameactinin alpha 1phosphatase and actin regulator 4
SynonymsBDPLT15PPP1R124
Cytomap('ACTN1')('PHACTR4')

14q24.1|14q22-q24

1p35.3

Type of geneprotein-codingprotein-coding
Descriptionalpha-actinin-1F-actin cross-linking proteinactinin 1 smooth musclealpha-actinin cytoskeletal isoformepididymis secretory sperm binding proteinnon-muscle alpha-actinin-1phosphatase and actin regulator 4protein phosphatase 1, regulatory subunit 124
Modification date2020032720200313
UniProtAcc

P12814

.
Ensembl transtripts involved in fusion geneENST00000193403, ENST00000376839, 
ENST00000394419, ENST00000438964, 
ENST00000538545, ENST00000554508, 
Fusion gene scores* DoF score14 X 14 X 4=7847 X 7 X 5=245
# samples 178
** MAII scorelog2(17/784*10)=-2.20531890797751
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACTN1 [Title/Abstract] AND PHACTR4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACTN1(69387723)-PHACTR4(28800066), # samples:1
Anticipated loss of major functional domain due to fusion event.ACTN1-PHACTR4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN1-PHACTR4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN1-PHACTR4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN1-PHACTR4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ACTN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PHACTR4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8365-01AACTN1chr14

69387723

-PHACTR4chr1

28800066

+


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Fusion Gene ORF analysis for ACTN1-PHACTR4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000193403ENST00000373836ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
5CDS-3UTRENST00000193403ENST00000493669ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
5CDS-3UTRENST00000376839ENST00000373836ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
5CDS-3UTRENST00000376839ENST00000493669ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
5CDS-3UTRENST00000394419ENST00000373836ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
5CDS-3UTRENST00000394419ENST00000493669ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
5CDS-3UTRENST00000438964ENST00000373836ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
5CDS-3UTRENST00000438964ENST00000493669ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
5CDS-3UTRENST00000538545ENST00000373836ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
5CDS-3UTRENST00000538545ENST00000493669ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
5UTR-3CDSENST00000554508ENST00000373839ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
5UTR-3UTRENST00000554508ENST00000373836ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
5UTR-3UTRENST00000554508ENST00000493669ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
In-frameENST00000193403ENST00000373839ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
In-frameENST00000376839ENST00000373839ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
In-frameENST00000394419ENST00000373839ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
In-frameENST00000438964ENST00000373839ACTN1chr14

69387723

-PHACTR4chr1

28800066

+
In-frameENST00000538545ENST00000373839ACTN1chr14

69387723

-PHACTR4chr1

28800066

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000193403ACTN1chr1469387723-ENST00000373839PHACTR4chr128800066+58307243842009541
ENST00000394419ACTN1chr1469387723-ENST00000373839PHACTR4chr128800066+56295231831808541
ENST00000438964ACTN1chr1469387723-ENST00000373839PHACTR4chr128800066+56525462061831541
ENST00000376839ACTN1chr1469387723-ENST00000373839PHACTR4chr128800066+55304242701709479
ENST00000538545ACTN1chr1469387723-ENST00000373839PHACTR4chr128800066+5466360201645541

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000193403ENST00000373839ACTN1chr1469387723-PHACTR4chr128800066+0.0025916970.99740833
ENST00000394419ENST00000373839ACTN1chr1469387723-PHACTR4chr128800066+0.0023595710.9976405
ENST00000438964ENST00000373839ACTN1chr1469387723-PHACTR4chr128800066+0.002434240.99756575
ENST00000376839ENST00000373839ACTN1chr1469387723-PHACTR4chr128800066+0.0009315610.99906844
ENST00000538545ENST00000373839ACTN1chr1469387723-PHACTR4chr128800066+0.0020028990.9979971

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Fusion Genomic Features for ACTN1-PHACTR4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACTN1chr1469387722-PHACTR4chr128800065+9.37E-080.9999999
ACTN1chr1469387722-PHACTR4chr128800065+9.37E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACTN1-PHACTR4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:69387723/chr1:28800066)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTN1

P12814

.
FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePHACTR4chr14:69387723chr1:28800066ENST00000373836413478_482284713.0Compositional biasNote=Poly-Glu
TgenePHACTR4chr14:69387723chr1:28800066ENST00000373836413508_513284713.0Compositional biasNote=Poly-Glu
TgenePHACTR4chr14:69387723chr1:28800066ENST00000373839514478_482274703.0Compositional biasNote=Poly-Glu
TgenePHACTR4chr14:69387723chr1:28800066ENST00000373839514508_513274703.0Compositional biasNote=Poly-Glu
TgenePHACTR4chr14:69387723chr1:28800066ENST00000373836413583_608284713.0RepeatNote=RPEL 2
TgenePHACTR4chr14:69387723chr1:28800066ENST00000373836413621_646284713.0RepeatNote=RPEL 3
TgenePHACTR4chr14:69387723chr1:28800066ENST00000373839514583_608274703.0RepeatNote=RPEL 2
TgenePHACTR4chr14:69387723chr1:28800066ENST00000373839514621_646274703.0RepeatNote=RPEL 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN1chr14:69387723chr1:28800066ENST00000193403-321759_770113893.0Calcium bindingOntology_term=ECO:0000255
HgeneACTN1chr14:69387723chr1:28800066ENST00000193403-321800_811113893.0Calcium bindingOntology_term=ECO:0000255
HgeneACTN1chr14:69387723chr1:28800066ENST00000394419-322759_770113915.0Calcium bindingOntology_term=ECO:0000255
HgeneACTN1chr14:69387723chr1:28800066ENST00000394419-322800_811113915.0Calcium bindingOntology_term=ECO:0000255
HgeneACTN1chr14:69387723chr1:28800066ENST00000438964-321759_770113888.0Calcium bindingOntology_term=ECO:0000255
HgeneACTN1chr14:69387723chr1:28800066ENST00000438964-321800_811113888.0Calcium bindingOntology_term=ECO:0000255
HgeneACTN1chr14:69387723chr1:28800066ENST00000538545-321759_770113931.0Calcium bindingOntology_term=ECO:0000255
HgeneACTN1chr14:69387723chr1:28800066ENST00000538545-321800_811113931.0Calcium bindingOntology_term=ECO:0000255
HgeneACTN1chr14:69387723chr1:28800066ENST00000193403-321144_250113893.0DomainCalponin-homology (CH) 2
HgeneACTN1chr14:69387723chr1:28800066ENST00000193403-32131_135113893.0DomainCalponin-homology (CH) 1
HgeneACTN1chr14:69387723chr1:28800066ENST00000193403-321746_781113893.0DomainEF-hand 1
HgeneACTN1chr14:69387723chr1:28800066ENST00000193403-321787_822113893.0DomainEF-hand 2
HgeneACTN1chr14:69387723chr1:28800066ENST00000394419-322144_250113915.0DomainCalponin-homology (CH) 2
HgeneACTN1chr14:69387723chr1:28800066ENST00000394419-32231_135113915.0DomainCalponin-homology (CH) 1
HgeneACTN1chr14:69387723chr1:28800066ENST00000394419-322746_781113915.0DomainEF-hand 1
HgeneACTN1chr14:69387723chr1:28800066ENST00000394419-322787_822113915.0DomainEF-hand 2
HgeneACTN1chr14:69387723chr1:28800066ENST00000438964-321144_250113888.0DomainCalponin-homology (CH) 2
HgeneACTN1chr14:69387723chr1:28800066ENST00000438964-32131_135113888.0DomainCalponin-homology (CH) 1
HgeneACTN1chr14:69387723chr1:28800066ENST00000438964-321746_781113888.0DomainEF-hand 1
HgeneACTN1chr14:69387723chr1:28800066ENST00000438964-321787_822113888.0DomainEF-hand 2
HgeneACTN1chr14:69387723chr1:28800066ENST00000538545-321144_250113931.0DomainCalponin-homology (CH) 2
HgeneACTN1chr14:69387723chr1:28800066ENST00000538545-32131_135113931.0DomainCalponin-homology (CH) 1
HgeneACTN1chr14:69387723chr1:28800066ENST00000538545-321746_781113931.0DomainEF-hand 1
HgeneACTN1chr14:69387723chr1:28800066ENST00000538545-321787_822113931.0DomainEF-hand 2
HgeneACTN1chr14:69387723chr1:28800066ENST00000193403-3211_247113893.0RegionNote=Actin-binding
HgeneACTN1chr14:69387723chr1:28800066ENST00000394419-3221_247113915.0RegionNote=Actin-binding
HgeneACTN1chr14:69387723chr1:28800066ENST00000438964-3211_247113888.0RegionNote=Actin-binding
HgeneACTN1chr14:69387723chr1:28800066ENST00000538545-3211_247113931.0RegionNote=Actin-binding
HgeneACTN1chr14:69387723chr1:28800066ENST00000193403-321274_384113893.0RepeatNote=Spectrin 1
HgeneACTN1chr14:69387723chr1:28800066ENST00000193403-321394_499113893.0RepeatNote=Spectrin 2
HgeneACTN1chr14:69387723chr1:28800066ENST00000193403-321509_620113893.0RepeatNote=Spectrin 3
HgeneACTN1chr14:69387723chr1:28800066ENST00000193403-321630_733113893.0RepeatNote=Spectrin 4
HgeneACTN1chr14:69387723chr1:28800066ENST00000394419-322274_384113915.0RepeatNote=Spectrin 1
HgeneACTN1chr14:69387723chr1:28800066ENST00000394419-322394_499113915.0RepeatNote=Spectrin 2
HgeneACTN1chr14:69387723chr1:28800066ENST00000394419-322509_620113915.0RepeatNote=Spectrin 3
HgeneACTN1chr14:69387723chr1:28800066ENST00000394419-322630_733113915.0RepeatNote=Spectrin 4
HgeneACTN1chr14:69387723chr1:28800066ENST00000438964-321274_384113888.0RepeatNote=Spectrin 1
HgeneACTN1chr14:69387723chr1:28800066ENST00000438964-321394_499113888.0RepeatNote=Spectrin 2
HgeneACTN1chr14:69387723chr1:28800066ENST00000438964-321509_620113888.0RepeatNote=Spectrin 3
HgeneACTN1chr14:69387723chr1:28800066ENST00000438964-321630_733113888.0RepeatNote=Spectrin 4
HgeneACTN1chr14:69387723chr1:28800066ENST00000538545-321274_384113931.0RepeatNote=Spectrin 1
HgeneACTN1chr14:69387723chr1:28800066ENST00000538545-321394_499113931.0RepeatNote=Spectrin 2
HgeneACTN1chr14:69387723chr1:28800066ENST00000538545-321509_620113931.0RepeatNote=Spectrin 3
HgeneACTN1chr14:69387723chr1:28800066ENST00000538545-321630_733113931.0RepeatNote=Spectrin 4
TgenePHACTR4chr14:69387723chr1:28800066ENST00000373836413227_433284713.0Compositional biasNote=Pro-rich
TgenePHACTR4chr14:69387723chr1:28800066ENST00000373839514227_433274703.0Compositional biasNote=Pro-rich
TgenePHACTR4chr14:69387723chr1:28800066ENST0000037383641363_88284713.0RepeatNote=RPEL 1
TgenePHACTR4chr14:69387723chr1:28800066ENST0000037383951463_88274703.0RepeatNote=RPEL 1


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Fusion Gene Sequence for ACTN1-PHACTR4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1747_1747_1_ACTN1-PHACTR4_ACTN1_chr14_69387723_ENST00000193403_PHACTR4_chr1_28800066_ENST00000373839_length(transcript)=5830nt_BP=724nt
AGGAATTCCCAATGAGAGGCGATGGGGGGAAGTTTGGGCAACTCGGCCTGGCCAATGGAGAGCCTCGGGAGGGCTCTGCCCCTTCCCCCC
GCCCCCGCCCGCCTCGGCTCCCGCAGCGCTAGTGTGTCCGCCTAGTTCAGTGTGCGTGGAGATTAGGTCCAAGCGCCCGCCCAGAGGCAG
GCAGTCCGCGAGCCCAGCCGCCGCTGTCGCCGCCAGTAGCAGCCTTCGCCAGCAGCGCCGCGGCGGAACCGGGCGCAGGGGAGCGAGCCC
GGCCCCGCCAGCCCAGCCCAGCCCAGCCCTACTCCCTCCCCACGCCAGGGCAGCAGCCGTTGCTCAGAGAGAAGGTGGAGGAAGAAATCC
AGACCCTAGCACGCGCGCACCATCATGGACCATTATGATTCTCAGCAAACCAACGATTACATGCAGCCAGAAGAGGACTGGGACCGGGAC
CTGCTCCTGGACCCGGCCTGGGAGAAGCAGCAGAGAAAGACATTCACGGCATGGTGTAACTCCCACCTCCGGAAGGCGGGGACACAGATC
GAGAACATCGAAGAGGACTTCCGGGATGGCCTGAAGCTCATGCTGCTGCTGGAGGTCATCTCAGGTGAACGCTTGGCCAAGCCAGAGCGA
GGCAAGATGAGAGTGCACAAGATCTCCAACGTCAACAAGGCCCTGGATTTCATAGCCAGCAAAGGCGTCAAACTGGTGTCCATCGGAGCC
GAAGCTGAACTGTCCCAAGCAATAAACAGTGGTACATTGTTATCAAAACCGTCCCCACCCTTACCACCTAAGAGAGGCATTCCATCAACC
TCAGTACCCACCTTGGAGTCTGCTGCTGCCATCACCACAAAAACACCAAGTGATGAAAGAGAGAAGAGCACGTGTTCTATGGGCTCGGAA
CTACTACCAATGATCTCACCTCGCTCTCCGTCCCCCCCACTGCCTACTCATATACCTCCAGAGCCTCCACGCACCCCTCCATTCCCTGCT
AAGACTTTTCAAGTTGTGCCAGAAATTGAGTTTCCACCATCCTTAGATCTACACCAGGAGATTCCCCAGCAGGAAGATCAGAAAAAGGAA
GTCCCCAAGAGGATACTGGACCAGAACTTTGGGGAGCCCCATATACCCTCTAGGCTGCCTCCACTCCCACTGCATATTCGAATCCAGCAG
GCCCTCACCAGCCCACTTCCCATGACTCCTATTCTGGAGGGTTCTCACAGAGCTCATTCGTTGCTTTTTGAAAACAGTGACAGCTTTTCT
GAGGACAGCAGTACGCTGGGTCGGACCAGGTCTCTTCCCATCACTATTGAAATGCTAAAAGTTCCAGACGATGAAGAAGAAGAGGAGCAA
ACCTGTCCATCCACATTCAGTGAAGAAATGACACCTACCTCAGTCATTCCTAAATTACCACAGTGTCTACGGGAGGAAGAAGAGAAGGAG
AGCGACTCTGATTCAGAAGGTCCCATTCAGTACCGAGATGAAGAAGATGAAGATGAAAGCTATCAGAGTGCTCTCGCCAACAAAGTGAAG
AGGAAAGACACACTGGCAATGAAGTTGAACCACAGACCCAGTGAACCAGAGTTGAACCTGAATTCTTGGCCTTGTAAAAGCAAGGAGGAG
TGGAATGAAATACGGCACCAGATTGGAAACACACTGATCCGGCGACTGAGTCAAAGACCAACACCAGAAGAACTAGAACAACGCAATATA
TTGCAACCTAAAAATGAAGCTGATCGTCAGGCAGAAAAACGAGAAATTAAACGTCGGCTCACTAGAAAGCTCAGTCAAAGGCCAACTGTC
GCTGAACTCCTTGCCAGGAAGATTCTGAGGTTTAATGAATATGTAGAGGTAACAGATGCTCAAGATTATGACCGGCGAGCCGACAAACCT
TGGACCAAACTGACCCCTGCTGACAAGGCTGCCATAAGAAAAGAATTAAATGAATTTAAAAGCTCCGAGATGGAGGTTCATGAAGAGAGC
AAACATTTTACACGCTACCATCGTCCATGATGCCAAAGGTTGAGAGAGGAATCAACATGGCTGCTTTGCTGCTTCCTTCTCCAAAGTGAC
ATATGGAGGGAACTTTAGCACTTCCCAGCACAGCCAGAATTGCATCCTCTGGGATCTTCTGAGGTGGACAGCACTTTGAATGTAGCATTT
CACTGGAACAGAGTCTTATGTGCTGCACCGGGGGCAAAACAACACTTTGTCAGTGCTTTTGAACCTTTCAATATTGTAGCATGCTTGAGG
AGTTTTTCCCTTACTGGCCACCAAAGTTCTGAACCACTTGCAGGTTCCAGGTTTTACTGGCTGCACCACACCCCTTCCCCTAGATGACTG
CCTGTGCAGAGACACAGTTTGCACCATTAGCCTTACCTGCCCTGCCCTGATTGTGAGACCCAAATGTGTAGGCTCTAAATTCCAGCCATC
AAATCCAATTCCTGGTGGGGAAAACCTTCTGGAGACCCCCAACCTTCTGATAAAAGAGTCTCTACCTCCAGGGAAAGCCTTCTTACCACA
CTGGCATATCAGATGAAAGCATTGCACTGTACCTCTCGTAACACAGCAATACAGTCCTCTTGAGGCACTCAAGCCTGAGAGGAAGCTCAG
GATCTGACATGTTCTTCCTTTTCCTCACAAGTCATCATGATTTTTTATTTTAAAATAATCTGGAAGTAATGGGAACTTAGTTTTTCCTGA
ACTCCAACCAGAATCCAAATTGGTTAGATGAGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGG
ATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTG
GCGCCTGGTTGAGGCATGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCTACTGCACTCCAGCCTGGGCA
ACAAAGTGGGACTCTGTCTTAAAAAAAAAAAAAAAAAAAAAATCGGTTAGATGAGAAAGCATGTATATTTTCTATATACAAAAACAAGAA
AGGCGTTTTGAGCCCCTGTGCTCAGGCCCACTCCCACACTGTGGAGTGTACTTTCATTTTCAATAAATCCCCTTATTCCTTCCTTGCAAA
AAAAAAAAAAAAAAAAGCCTTAGCCAGATTCAGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAG
TTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAAGTAAAAAAAATTAGCCGGGCATGGTGGCTTGTGC
CTTGTAGTCCCAGCCACTGGGGAGGCTGAGGCGGGAGAATTGCTTGAACCTGGGAGGTGGAGATTGCAGTGAGCCGAGATCGCGCCACTG
CACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAGCCTTAATATTAATGCTAACGTGGCAGAAAACTAGCAGG
TTACATTTTATAGGCTATTGTAGTTTTATTTACCAAATGATATTCTCTAAATCACTTCGACCAATAAATGTATTCTCCTCCTTAAAGCAG
AGTTGTATCAACTCTGTGGGAGCATTTATGAGCTGTCAGTCCCCACACTTCTAGCCAGAATCACAATAAGGTCTGGCTGGGTGTGGGGTG
CTGCATAGGAAAGGGTCTCTGGAGAAGCAAGAAGGGCACAATCATGGCCCACTGCTCCCCTCTTCTTCTCAGTGCTCTTTGCCCTCTCCT
GCTGCGTGCTTCCTCTTCACTCCAGTGCTGATCCTCCTGCTCTCTCTGGCAGCTTCCACCTCACCCGCCCCTCTTCCACACTATAACCAG
TATGGTTGGTGCTGGGGCATTGACTCAGCCCCCCTGCTTTCTGCATTTGTAATAGATATTAATATGATTTCCTAAAACAGAAGATTTTGT
TGCTTTCTTTGAACTTGTATTGAAAACCATACAGTCTCACTGTTTTGCTTTAATTCCTATCCACACTATAAATGGAAGAAAAAAATTAAT
AGCTTCTGTTTAATCTGATGAATGTGGCTTTTTTTCCCTTCACTTTAATGTTCAAGAAGTTGTGGCTATTTCATAGATTTCTTCTGATTT
ATTCTGTGGGTCCCTGTTATCTGTTCTTTATGTAATCTTTCAGTAGATTTTCATCCTTTCATATCCACATTCTTATGTGGACTTGCTGAA
GAAACAGAATATCAGTTCAAAACAAAACCTAGGCCAGGCATGGTGGTTCACGCCTATAATCTCAGCACTTTGGGAAGCCAAGGCGGTCAG
GAGTTTGAGACCAGCCTGACCAACATGATGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCTGGCGTGGTGGCACGCATCTGTAAT
CCCAACTACTCAGGACGCTGAGGCAGGAGAGTCGCTTGAACCCAGGAGGCGGAGATTGCAGTGAGCCAAGATTGCACCACTGCACTCCAG
CCTGGGCAACAGAGCGAGACTCCATCAAAAAAAAAAAAAAAAAAGAAGGAAGGAAGGAAAGCAAGCCCTGAATCCACATCTCCTTGAAGT
TTTTTTTGTTTTATTTTGTTTTTGAGACAGAATTTTGCTCTTGTTGCCCAGGCCGGAGTGCAATGGTGCAATCTCAGCTCACTGCAACCT
CCGCCTCCCGGGTTGAGGCGATTCTCCTACCTCAGCCTCCCAAGTAGCTAGGATTACAGGCATGAGCCACCACGCCTGGCTAATTTTATA
TTTCTAGTAGAGATGAGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCCGACCTCAGGTGATCCACCCACCTCAGCCTCCCAAAGT
GGTGGGATTACAGGCATGAGCCACCGTGCCGAGCCTTCCTTGAAGTTTTTTGTTTGGTTTTGATTTGTTTTGTTTTGTTTTGTTTTGTTT
TGTTTTTGGAGATAGGGTCTCACTCTGTTACCCATGCTGGAGTGCAGTGGCACAATCTTGGCTCAGAGCAACCTCTGCCTCCCAGGCTCA
AGCAATCCTCCCACTTCAGTCTAAGTAGCTGGGACTACAGGCACGTGCCACCAGGCCCAGCTAATTTTTGTGTTTTGTTAGAGATGAGGT
TTTGCCATATTGCCCAGGCTCGTCTTGAACACCGGGGCTCAAGGAATCTGCCCATCTTCGCCTCCCAAAGTTCTGAGATAGCAGGTGTGA
GTCATCATGCCCAGCCTCCTTGAAGTTTACTAACAATTGGGATAACTGAGGGAAGAGAAGTGACAATTCCACTCAGTCTATTAGAGGTCT
GGATATAAGGTAGCCACACAATAACTCTAACTTGACTTCTAACCATTCTATCTTATTGATTTGGAGGCTGTCTTCTGCCAGATTTTTTGT
GGCTTGAGATGATATTTTCGAACCCTTCTTTCACTACCTTTCTTACCCTTAATGTGCCAAGCTTGAAACAGGATTTGATTTCCTGAGCTA
CTTGTTCGCCTTCTGTGCGTCACCAAGTAATCTGGTTCATCTTTCGTCTCATTCATGTTATTTTCAAGTGAAACAAGACATTTTGGGGGT
CAAGTCTCTTTGGGTGTTTTGTTTTTATGTATATAAAAATGGATTTTGTGTTCCCTTTCCATGTAAGTACCAACTTATATGGAAACTCAC
AATCATAATGTAAAGAAGAAATGAAAGCCTGGTGTATTGTACTTCAAGATGCCTCCCTGATGTATAGAATCTCCTTGTAAAATAAATAAT

>1747_1747_1_ACTN1-PHACTR4_ACTN1_chr14_69387723_ENST00000193403_PHACTR4_chr1_28800066_ENST00000373839_length(amino acids)=541AA_BP=113
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKI
SNVNKALDFIASKGVKLVSIGAEAELSQAINSGTLLSKPSPPLPPKRGIPSTSVPTLESAAAITTKTPSDEREKSTCSMGSELLPMISPR
SPSPPLPTHIPPEPPRTPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPLPM
TPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPSTFSEEMTPTSVIPKLPQCLREEEEKESDSDSEGP
IQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELNLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEAD
RQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHR

--------------------------------------------------------------
>1747_1747_2_ACTN1-PHACTR4_ACTN1_chr14_69387723_ENST00000376839_PHACTR4_chr1_28800066_ENST00000373839_length(transcript)=5530nt_BP=424nt
AAAACACACACAATGGGCTTCCTCAAAGCAGGATGACCTGGGCCGCGGTGCCCAAGGCCTATGCAGGGCTGGGCCCTATACAGCGACATC
GGTCATCTACATCGGACATGGGAAGGTCCCCTGACTTCGAACTGACTTCTTTGTAATGTGCCAGTTGCTTAAACTCCCCCTCTTCCTGTC
ATCTTCCTAACATTCACGGCATGGTGTAACTCCCACCTCCGGAAGGCGGGGACACAGATCGAGAACATCGAAGAGGACTTCCGGGATGGC
CTGAAGCTCATGCTGCTGCTGGAGGTCATCTCAGGTGAACGCTTGGCCAAGCCAGAGCGAGGCAAGATGAGAGTGCACAAGATCTCCAAC
GTCAACAAGGCCCTGGATTTCATAGCCAGCAAAGGCGTCAAACTGGTGTCCATCGGAGCCGAAGCTGAACTGTCCCAAGCAATAAACAGT
GGTACATTGTTATCAAAACCGTCCCCACCCTTACCACCTAAGAGAGGCATTCCATCAACCTCAGTACCCACCTTGGAGTCTGCTGCTGCC
ATCACCACAAAAACACCAAGTGATGAAAGAGAGAAGAGCACGTGTTCTATGGGCTCGGAACTACTACCAATGATCTCACCTCGCTCTCCG
TCCCCCCCACTGCCTACTCATATACCTCCAGAGCCTCCACGCACCCCTCCATTCCCTGCTAAGACTTTTCAAGTTGTGCCAGAAATTGAG
TTTCCACCATCCTTAGATCTACACCAGGAGATTCCCCAGCAGGAAGATCAGAAAAAGGAAGTCCCCAAGAGGATACTGGACCAGAACTTT
GGGGAGCCCCATATACCCTCTAGGCTGCCTCCACTCCCACTGCATATTCGAATCCAGCAGGCCCTCACCAGCCCACTTCCCATGACTCCT
ATTCTGGAGGGTTCTCACAGAGCTCATTCGTTGCTTTTTGAAAACAGTGACAGCTTTTCTGAGGACAGCAGTACGCTGGGTCGGACCAGG
TCTCTTCCCATCACTATTGAAATGCTAAAAGTTCCAGACGATGAAGAAGAAGAGGAGCAAACCTGTCCATCCACATTCAGTGAAGAAATG
ACACCTACCTCAGTCATTCCTAAATTACCACAGTGTCTACGGGAGGAAGAAGAGAAGGAGAGCGACTCTGATTCAGAAGGTCCCATTCAG
TACCGAGATGAAGAAGATGAAGATGAAAGCTATCAGAGTGCTCTCGCCAACAAAGTGAAGAGGAAAGACACACTGGCAATGAAGTTGAAC
CACAGACCCAGTGAACCAGAGTTGAACCTGAATTCTTGGCCTTGTAAAAGCAAGGAGGAGTGGAATGAAATACGGCACCAGATTGGAAAC
ACACTGATCCGGCGACTGAGTCAAAGACCAACACCAGAAGAACTAGAACAACGCAATATATTGCAACCTAAAAATGAAGCTGATCGTCAG
GCAGAAAAACGAGAAATTAAACGTCGGCTCACTAGAAAGCTCAGTCAAAGGCCAACTGTCGCTGAACTCCTTGCCAGGAAGATTCTGAGG
TTTAATGAATATGTAGAGGTAACAGATGCTCAAGATTATGACCGGCGAGCCGACAAACCTTGGACCAAACTGACCCCTGCTGACAAGGCT
GCCATAAGAAAAGAATTAAATGAATTTAAAAGCTCCGAGATGGAGGTTCATGAAGAGAGCAAACATTTTACACGCTACCATCGTCCATGA
TGCCAAAGGTTGAGAGAGGAATCAACATGGCTGCTTTGCTGCTTCCTTCTCCAAAGTGACATATGGAGGGAACTTTAGCACTTCCCAGCA
CAGCCAGAATTGCATCCTCTGGGATCTTCTGAGGTGGACAGCACTTTGAATGTAGCATTTCACTGGAACAGAGTCTTATGTGCTGCACCG
GGGGCAAAACAACACTTTGTCAGTGCTTTTGAACCTTTCAATATTGTAGCATGCTTGAGGAGTTTTTCCCTTACTGGCCACCAAAGTTCT
GAACCACTTGCAGGTTCCAGGTTTTACTGGCTGCACCACACCCCTTCCCCTAGATGACTGCCTGTGCAGAGACACAGTTTGCACCATTAG
CCTTACCTGCCCTGCCCTGATTGTGAGACCCAAATGTGTAGGCTCTAAATTCCAGCCATCAAATCCAATTCCTGGTGGGGAAAACCTTCT
GGAGACCCCCAACCTTCTGATAAAAGAGTCTCTACCTCCAGGGAAAGCCTTCTTACCACACTGGCATATCAGATGAAAGCATTGCACTGT
ACCTCTCGTAACACAGCAATACAGTCCTCTTGAGGCACTCAAGCCTGAGAGGAAGCTCAGGATCTGACATGTTCTTCCTTTTCCTCACAA
GTCATCATGATTTTTTATTTTAAAATAATCTGGAAGTAATGGGAACTTAGTTTTTCCTGAACTCCAACCAGAATCCAAATTGGTTAGATG
AGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGC
CTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCGCCTGGTTGAGGCATGAGAATCGCTTGA
ACCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCTACTGCACTCCAGCCTGGGCAACAAAGTGGGACTCTGTCTTAAAAAAAAAA
AAAAAAAAAAAATCGGTTAGATGAGAAAGCATGTATATTTTCTATATACAAAAACAAGAAAGGCGTTTTGAGCCCCTGTGCTCAGGCCCA
CTCCCACACTGTGGAGTGTACTTTCATTTTCAATAAATCCCCTTATTCCTTCCTTGCAAAAAAAAAAAAAAAAAAAGCCTTAGCCAGATT
CAGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGTTCAGGAGTTCAAGACCAGCCTGGCCAACA
TGGCAAAACCCTGTCTCTACTAAAAAGTAAAAAAAATTAGCCGGGCATGGTGGCTTGTGCCTTGTAGTCCCAGCCACTGGGGAGGCTGAG
GCGGGAGAATTGCTTGAACCTGGGAGGTGGAGATTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTC
CGTCTCAAAAAAAAAAAAAAAGCCTTAATATTAATGCTAACGTGGCAGAAAACTAGCAGGTTACATTTTATAGGCTATTGTAGTTTTATT
TACCAAATGATATTCTCTAAATCACTTCGACCAATAAATGTATTCTCCTCCTTAAAGCAGAGTTGTATCAACTCTGTGGGAGCATTTATG
AGCTGTCAGTCCCCACACTTCTAGCCAGAATCACAATAAGGTCTGGCTGGGTGTGGGGTGCTGCATAGGAAAGGGTCTCTGGAGAAGCAA
GAAGGGCACAATCATGGCCCACTGCTCCCCTCTTCTTCTCAGTGCTCTTTGCCCTCTCCTGCTGCGTGCTTCCTCTTCACTCCAGTGCTG
ATCCTCCTGCTCTCTCTGGCAGCTTCCACCTCACCCGCCCCTCTTCCACACTATAACCAGTATGGTTGGTGCTGGGGCATTGACTCAGCC
CCCCTGCTTTCTGCATTTGTAATAGATATTAATATGATTTCCTAAAACAGAAGATTTTGTTGCTTTCTTTGAACTTGTATTGAAAACCAT
ACAGTCTCACTGTTTTGCTTTAATTCCTATCCACACTATAAATGGAAGAAAAAAATTAATAGCTTCTGTTTAATCTGATGAATGTGGCTT
TTTTTCCCTTCACTTTAATGTTCAAGAAGTTGTGGCTATTTCATAGATTTCTTCTGATTTATTCTGTGGGTCCCTGTTATCTGTTCTTTA
TGTAATCTTTCAGTAGATTTTCATCCTTTCATATCCACATTCTTATGTGGACTTGCTGAAGAAACAGAATATCAGTTCAAAACAAAACCT
AGGCCAGGCATGGTGGTTCACGCCTATAATCTCAGCACTTTGGGAAGCCAAGGCGGTCAGGAGTTTGAGACCAGCCTGACCAACATGATG
AAACCCTGTCTCTACTAAAAATACAAAAATTAGCCTGGCGTGGTGGCACGCATCTGTAATCCCAACTACTCAGGACGCTGAGGCAGGAGA
GTCGCTTGAACCCAGGAGGCGGAGATTGCAGTGAGCCAAGATTGCACCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCATCAAAA
AAAAAAAAAAAAAAGAAGGAAGGAAGGAAAGCAAGCCCTGAATCCACATCTCCTTGAAGTTTTTTTTGTTTTATTTTGTTTTTGAGACAG
AATTTTGCTCTTGTTGCCCAGGCCGGAGTGCAATGGTGCAATCTCAGCTCACTGCAACCTCCGCCTCCCGGGTTGAGGCGATTCTCCTAC
CTCAGCCTCCCAAGTAGCTAGGATTACAGGCATGAGCCACCACGCCTGGCTAATTTTATATTTCTAGTAGAGATGAGGTTTCTCCATGTT
GGTCAGGCTGGTCTCAAACTCCCGACCTCAGGTGATCCACCCACCTCAGCCTCCCAAAGTGGTGGGATTACAGGCATGAGCCACCGTGCC
GAGCCTTCCTTGAAGTTTTTTGTTTGGTTTTGATTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTTGGAGATAGGGTCTCACTCTGTTA
CCCATGCTGGAGTGCAGTGGCACAATCTTGGCTCAGAGCAACCTCTGCCTCCCAGGCTCAAGCAATCCTCCCACTTCAGTCTAAGTAGCT
GGGACTACAGGCACGTGCCACCAGGCCCAGCTAATTTTTGTGTTTTGTTAGAGATGAGGTTTTGCCATATTGCCCAGGCTCGTCTTGAAC
ACCGGGGCTCAAGGAATCTGCCCATCTTCGCCTCCCAAAGTTCTGAGATAGCAGGTGTGAGTCATCATGCCCAGCCTCCTTGAAGTTTAC
TAACAATTGGGATAACTGAGGGAAGAGAAGTGACAATTCCACTCAGTCTATTAGAGGTCTGGATATAAGGTAGCCACACAATAACTCTAA
CTTGACTTCTAACCATTCTATCTTATTGATTTGGAGGCTGTCTTCTGCCAGATTTTTTGTGGCTTGAGATGATATTTTCGAACCCTTCTT
TCACTACCTTTCTTACCCTTAATGTGCCAAGCTTGAAACAGGATTTGATTTCCTGAGCTACTTGTTCGCCTTCTGTGCGTCACCAAGTAA
TCTGGTTCATCTTTCGTCTCATTCATGTTATTTTCAAGTGAAACAAGACATTTTGGGGGTCAAGTCTCTTTGGGTGTTTTGTTTTTATGT
ATATAAAAATGGATTTTGTGTTCCCTTTCCATGTAAGTACCAACTTATATGGAAACTCACAATCATAATGTAAAGAAGAAATGAAAGCCT
GGTGTATTGTACTTCAAGATGCCTCCCTGATGTATAGAATCTCCTTGTAAAATAAATAATTGCATTGTATATCAGTCTTCCCATCAATAT

>1747_1747_2_ACTN1-PHACTR4_ACTN1_chr14_69387723_ENST00000376839_PHACTR4_chr1_28800066_ENST00000373839_length(amino acids)=479AA_BP=51
MKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEAELSQAINSGTLLSKPSPPLPPKRGIPSTSVPTLESAAA
ITTKTPSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNF
GEPHIPSRLPPLPLHIRIQQALTSPLPMTPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPSTFSEEM
TPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELNLNSWPCKSKEEWNEIRHQIGN
TLIRRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKA

--------------------------------------------------------------
>1747_1747_3_ACTN1-PHACTR4_ACTN1_chr14_69387723_ENST00000394419_PHACTR4_chr1_28800066_ENST00000373839_length(transcript)=5629nt_BP=523nt
CGCTGTCGCCGCCAGTAGCAGCCTTCGCCAGCAGCGCCGCGGCGGAACCGGGCGCAGGGGAGCGAGCCCGGCCCCGCCAGCCCAGCCCAG
CCCAGCCCTACTCCCTCCCCACGCCAGGGCAGCAGCCGTTGCTCAGAGAGAAGGTGGAGGAAGAAATCCAGACCCTAGCACGCGCGCACC
ATCATGGACCATTATGATTCTCAGCAAACCAACGATTACATGCAGCCAGAAGAGGACTGGGACCGGGACCTGCTCCTGGACCCGGCCTGG
GAGAAGCAGCAGAGAAAGACATTCACGGCATGGTGTAACTCCCACCTCCGGAAGGCGGGGACACAGATCGAGAACATCGAAGAGGACTTC
CGGGATGGCCTGAAGCTCATGCTGCTGCTGGAGGTCATCTCAGGTGAACGCTTGGCCAAGCCAGAGCGAGGCAAGATGAGAGTGCACAAG
ATCTCCAACGTCAACAAGGCCCTGGATTTCATAGCCAGCAAAGGCGTCAAACTGGTGTCCATCGGAGCCGAAGCTGAACTGTCCCAAGCA
ATAAACAGTGGTACATTGTTATCAAAACCGTCCCCACCCTTACCACCTAAGAGAGGCATTCCATCAACCTCAGTACCCACCTTGGAGTCT
GCTGCTGCCATCACCACAAAAACACCAAGTGATGAAAGAGAGAAGAGCACGTGTTCTATGGGCTCGGAACTACTACCAATGATCTCACCT
CGCTCTCCGTCCCCCCCACTGCCTACTCATATACCTCCAGAGCCTCCACGCACCCCTCCATTCCCTGCTAAGACTTTTCAAGTTGTGCCA
GAAATTGAGTTTCCACCATCCTTAGATCTACACCAGGAGATTCCCCAGCAGGAAGATCAGAAAAAGGAAGTCCCCAAGAGGATACTGGAC
CAGAACTTTGGGGAGCCCCATATACCCTCTAGGCTGCCTCCACTCCCACTGCATATTCGAATCCAGCAGGCCCTCACCAGCCCACTTCCC
ATGACTCCTATTCTGGAGGGTTCTCACAGAGCTCATTCGTTGCTTTTTGAAAACAGTGACAGCTTTTCTGAGGACAGCAGTACGCTGGGT
CGGACCAGGTCTCTTCCCATCACTATTGAAATGCTAAAAGTTCCAGACGATGAAGAAGAAGAGGAGCAAACCTGTCCATCCACATTCAGT
GAAGAAATGACACCTACCTCAGTCATTCCTAAATTACCACAGTGTCTACGGGAGGAAGAAGAGAAGGAGAGCGACTCTGATTCAGAAGGT
CCCATTCAGTACCGAGATGAAGAAGATGAAGATGAAAGCTATCAGAGTGCTCTCGCCAACAAAGTGAAGAGGAAAGACACACTGGCAATG
AAGTTGAACCACAGACCCAGTGAACCAGAGTTGAACCTGAATTCTTGGCCTTGTAAAAGCAAGGAGGAGTGGAATGAAATACGGCACCAG
ATTGGAAACACACTGATCCGGCGACTGAGTCAAAGACCAACACCAGAAGAACTAGAACAACGCAATATATTGCAACCTAAAAATGAAGCT
GATCGTCAGGCAGAAAAACGAGAAATTAAACGTCGGCTCACTAGAAAGCTCAGTCAAAGGCCAACTGTCGCTGAACTCCTTGCCAGGAAG
ATTCTGAGGTTTAATGAATATGTAGAGGTAACAGATGCTCAAGATTATGACCGGCGAGCCGACAAACCTTGGACCAAACTGACCCCTGCT
GACAAGGCTGCCATAAGAAAAGAATTAAATGAATTTAAAAGCTCCGAGATGGAGGTTCATGAAGAGAGCAAACATTTTACACGCTACCAT
CGTCCATGATGCCAAAGGTTGAGAGAGGAATCAACATGGCTGCTTTGCTGCTTCCTTCTCCAAAGTGACATATGGAGGGAACTTTAGCAC
TTCCCAGCACAGCCAGAATTGCATCCTCTGGGATCTTCTGAGGTGGACAGCACTTTGAATGTAGCATTTCACTGGAACAGAGTCTTATGT
GCTGCACCGGGGGCAAAACAACACTTTGTCAGTGCTTTTGAACCTTTCAATATTGTAGCATGCTTGAGGAGTTTTTCCCTTACTGGCCAC
CAAAGTTCTGAACCACTTGCAGGTTCCAGGTTTTACTGGCTGCACCACACCCCTTCCCCTAGATGACTGCCTGTGCAGAGACACAGTTTG
CACCATTAGCCTTACCTGCCCTGCCCTGATTGTGAGACCCAAATGTGTAGGCTCTAAATTCCAGCCATCAAATCCAATTCCTGGTGGGGA
AAACCTTCTGGAGACCCCCAACCTTCTGATAAAAGAGTCTCTACCTCCAGGGAAAGCCTTCTTACCACACTGGCATATCAGATGAAAGCA
TTGCACTGTACCTCTCGTAACACAGCAATACAGTCCTCTTGAGGCACTCAAGCCTGAGAGGAAGCTCAGGATCTGACATGTTCTTCCTTT
TCCTCACAAGTCATCATGATTTTTTATTTTAAAATAATCTGGAAGTAATGGGAACTTAGTTTTTCCTGAACTCCAACCAGAATCCAAATT
GGTTAGATGAGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTC
AAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCGCCTGGTTGAGGCATGAGA
ATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCTACTGCACTCCAGCCTGGGCAACAAAGTGGGACTCTGTCTTA
AAAAAAAAAAAAAAAAAAAAATCGGTTAGATGAGAAAGCATGTATATTTTCTATATACAAAAACAAGAAAGGCGTTTTGAGCCCCTGTGC
TCAGGCCCACTCCCACACTGTGGAGTGTACTTTCATTTTCAATAAATCCCCTTATTCCTTCCTTGCAAAAAAAAAAAAAAAAAAAGCCTT
AGCCAGATTCAGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGTTCAGGAGTTCAAGACCAGCC
TGGCCAACATGGCAAAACCCTGTCTCTACTAAAAAGTAAAAAAAATTAGCCGGGCATGGTGGCTTGTGCCTTGTAGTCCCAGCCACTGGG
GAGGCTGAGGCGGGAGAATTGCTTGAACCTGGGAGGTGGAGATTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGTGACAGA
GCGAGACTCCGTCTCAAAAAAAAAAAAAAAGCCTTAATATTAATGCTAACGTGGCAGAAAACTAGCAGGTTACATTTTATAGGCTATTGT
AGTTTTATTTACCAAATGATATTCTCTAAATCACTTCGACCAATAAATGTATTCTCCTCCTTAAAGCAGAGTTGTATCAACTCTGTGGGA
GCATTTATGAGCTGTCAGTCCCCACACTTCTAGCCAGAATCACAATAAGGTCTGGCTGGGTGTGGGGTGCTGCATAGGAAAGGGTCTCTG
GAGAAGCAAGAAGGGCACAATCATGGCCCACTGCTCCCCTCTTCTTCTCAGTGCTCTTTGCCCTCTCCTGCTGCGTGCTTCCTCTTCACT
CCAGTGCTGATCCTCCTGCTCTCTCTGGCAGCTTCCACCTCACCCGCCCCTCTTCCACACTATAACCAGTATGGTTGGTGCTGGGGCATT
GACTCAGCCCCCCTGCTTTCTGCATTTGTAATAGATATTAATATGATTTCCTAAAACAGAAGATTTTGTTGCTTTCTTTGAACTTGTATT
GAAAACCATACAGTCTCACTGTTTTGCTTTAATTCCTATCCACACTATAAATGGAAGAAAAAAATTAATAGCTTCTGTTTAATCTGATGA
ATGTGGCTTTTTTTCCCTTCACTTTAATGTTCAAGAAGTTGTGGCTATTTCATAGATTTCTTCTGATTTATTCTGTGGGTCCCTGTTATC
TGTTCTTTATGTAATCTTTCAGTAGATTTTCATCCTTTCATATCCACATTCTTATGTGGACTTGCTGAAGAAACAGAATATCAGTTCAAA
ACAAAACCTAGGCCAGGCATGGTGGTTCACGCCTATAATCTCAGCACTTTGGGAAGCCAAGGCGGTCAGGAGTTTGAGACCAGCCTGACC
AACATGATGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCTGGCGTGGTGGCACGCATCTGTAATCCCAACTACTCAGGACGCTGA
GGCAGGAGAGTCGCTTGAACCCAGGAGGCGGAGATTGCAGTGAGCCAAGATTGCACCACTGCACTCCAGCCTGGGCAACAGAGCGAGACT
CCATCAAAAAAAAAAAAAAAAAAGAAGGAAGGAAGGAAAGCAAGCCCTGAATCCACATCTCCTTGAAGTTTTTTTTGTTTTATTTTGTTT
TTGAGACAGAATTTTGCTCTTGTTGCCCAGGCCGGAGTGCAATGGTGCAATCTCAGCTCACTGCAACCTCCGCCTCCCGGGTTGAGGCGA
TTCTCCTACCTCAGCCTCCCAAGTAGCTAGGATTACAGGCATGAGCCACCACGCCTGGCTAATTTTATATTTCTAGTAGAGATGAGGTTT
CTCCATGTTGGTCAGGCTGGTCTCAAACTCCCGACCTCAGGTGATCCACCCACCTCAGCCTCCCAAAGTGGTGGGATTACAGGCATGAGC
CACCGTGCCGAGCCTTCCTTGAAGTTTTTTGTTTGGTTTTGATTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTTGGAGATAGGGTCTC
ACTCTGTTACCCATGCTGGAGTGCAGTGGCACAATCTTGGCTCAGAGCAACCTCTGCCTCCCAGGCTCAAGCAATCCTCCCACTTCAGTC
TAAGTAGCTGGGACTACAGGCACGTGCCACCAGGCCCAGCTAATTTTTGTGTTTTGTTAGAGATGAGGTTTTGCCATATTGCCCAGGCTC
GTCTTGAACACCGGGGCTCAAGGAATCTGCCCATCTTCGCCTCCCAAAGTTCTGAGATAGCAGGTGTGAGTCATCATGCCCAGCCTCCTT
GAAGTTTACTAACAATTGGGATAACTGAGGGAAGAGAAGTGACAATTCCACTCAGTCTATTAGAGGTCTGGATATAAGGTAGCCACACAA
TAACTCTAACTTGACTTCTAACCATTCTATCTTATTGATTTGGAGGCTGTCTTCTGCCAGATTTTTTGTGGCTTGAGATGATATTTTCGA
ACCCTTCTTTCACTACCTTTCTTACCCTTAATGTGCCAAGCTTGAAACAGGATTTGATTTCCTGAGCTACTTGTTCGCCTTCTGTGCGTC
ACCAAGTAATCTGGTTCATCTTTCGTCTCATTCATGTTATTTTCAAGTGAAACAAGACATTTTGGGGGTCAAGTCTCTTTGGGTGTTTTG
TTTTTATGTATATAAAAATGGATTTTGTGTTCCCTTTCCATGTAAGTACCAACTTATATGGAAACTCACAATCATAATGTAAAGAAGAAA
TGAAAGCCTGGTGTATTGTACTTCAAGATGCCTCCCTGATGTATAGAATCTCCTTGTAAAATAAATAATTGCATTGTATATCAGTCTTCC

>1747_1747_3_ACTN1-PHACTR4_ACTN1_chr14_69387723_ENST00000394419_PHACTR4_chr1_28800066_ENST00000373839_length(amino acids)=541AA_BP=113
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKI
SNVNKALDFIASKGVKLVSIGAEAELSQAINSGTLLSKPSPPLPPKRGIPSTSVPTLESAAAITTKTPSDEREKSTCSMGSELLPMISPR
SPSPPLPTHIPPEPPRTPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPLPM
TPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPSTFSEEMTPTSVIPKLPQCLREEEEKESDSDSEGP
IQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELNLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEAD
RQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHR

--------------------------------------------------------------
>1747_1747_4_ACTN1-PHACTR4_ACTN1_chr14_69387723_ENST00000438964_PHACTR4_chr1_28800066_ENST00000373839_length(transcript)=5652nt_BP=546nt
AGGCAGTCCGCGAGCCCAGCCGCCGCTGTCGCCGCCAGTAGCAGCCTTCGCCAGCAGCGCCGCGGCGGAACCGGGCGCAGGGGAGCGAGC
CCGGCCCCGCCAGCCCAGCCCAGCCCAGCCCTACTCCCTCCCCACGCCAGGGCAGCAGCCGTTGCTCAGAGAGAAGGTGGAGGAAGAAAT
CCAGACCCTAGCACGCGCGCACCATCATGGACCATTATGATTCTCAGCAAACCAACGATTACATGCAGCCAGAAGAGGACTGGGACCGGG
ACCTGCTCCTGGACCCGGCCTGGGAGAAGCAGCAGAGAAAGACATTCACGGCATGGTGTAACTCCCACCTCCGGAAGGCGGGGACACAGA
TCGAGAACATCGAAGAGGACTTCCGGGATGGCCTGAAGCTCATGCTGCTGCTGGAGGTCATCTCAGGTGAACGCTTGGCCAAGCCAGAGC
GAGGCAAGATGAGAGTGCACAAGATCTCCAACGTCAACAAGGCCCTGGATTTCATAGCCAGCAAAGGCGTCAAACTGGTGTCCATCGGAG
CCGAAGCTGAACTGTCCCAAGCAATAAACAGTGGTACATTGTTATCAAAACCGTCCCCACCCTTACCACCTAAGAGAGGCATTCCATCAA
CCTCAGTACCCACCTTGGAGTCTGCTGCTGCCATCACCACAAAAACACCAAGTGATGAAAGAGAGAAGAGCACGTGTTCTATGGGCTCGG
AACTACTACCAATGATCTCACCTCGCTCTCCGTCCCCCCCACTGCCTACTCATATACCTCCAGAGCCTCCACGCACCCCTCCATTCCCTG
CTAAGACTTTTCAAGTTGTGCCAGAAATTGAGTTTCCACCATCCTTAGATCTACACCAGGAGATTCCCCAGCAGGAAGATCAGAAAAAGG
AAGTCCCCAAGAGGATACTGGACCAGAACTTTGGGGAGCCCCATATACCCTCTAGGCTGCCTCCACTCCCACTGCATATTCGAATCCAGC
AGGCCCTCACCAGCCCACTTCCCATGACTCCTATTCTGGAGGGTTCTCACAGAGCTCATTCGTTGCTTTTTGAAAACAGTGACAGCTTTT
CTGAGGACAGCAGTACGCTGGGTCGGACCAGGTCTCTTCCCATCACTATTGAAATGCTAAAAGTTCCAGACGATGAAGAAGAAGAGGAGC
AAACCTGTCCATCCACATTCAGTGAAGAAATGACACCTACCTCAGTCATTCCTAAATTACCACAGTGTCTACGGGAGGAAGAAGAGAAGG
AGAGCGACTCTGATTCAGAAGGTCCCATTCAGTACCGAGATGAAGAAGATGAAGATGAAAGCTATCAGAGTGCTCTCGCCAACAAAGTGA
AGAGGAAAGACACACTGGCAATGAAGTTGAACCACAGACCCAGTGAACCAGAGTTGAACCTGAATTCTTGGCCTTGTAAAAGCAAGGAGG
AGTGGAATGAAATACGGCACCAGATTGGAAACACACTGATCCGGCGACTGAGTCAAAGACCAACACCAGAAGAACTAGAACAACGCAATA
TATTGCAACCTAAAAATGAAGCTGATCGTCAGGCAGAAAAACGAGAAATTAAACGTCGGCTCACTAGAAAGCTCAGTCAAAGGCCAACTG
TCGCTGAACTCCTTGCCAGGAAGATTCTGAGGTTTAATGAATATGTAGAGGTAACAGATGCTCAAGATTATGACCGGCGAGCCGACAAAC
CTTGGACCAAACTGACCCCTGCTGACAAGGCTGCCATAAGAAAAGAATTAAATGAATTTAAAAGCTCCGAGATGGAGGTTCATGAAGAGA
GCAAACATTTTACACGCTACCATCGTCCATGATGCCAAAGGTTGAGAGAGGAATCAACATGGCTGCTTTGCTGCTTCCTTCTCCAAAGTG
ACATATGGAGGGAACTTTAGCACTTCCCAGCACAGCCAGAATTGCATCCTCTGGGATCTTCTGAGGTGGACAGCACTTTGAATGTAGCAT
TTCACTGGAACAGAGTCTTATGTGCTGCACCGGGGGCAAAACAACACTTTGTCAGTGCTTTTGAACCTTTCAATATTGTAGCATGCTTGA
GGAGTTTTTCCCTTACTGGCCACCAAAGTTCTGAACCACTTGCAGGTTCCAGGTTTTACTGGCTGCACCACACCCCTTCCCCTAGATGAC
TGCCTGTGCAGAGACACAGTTTGCACCATTAGCCTTACCTGCCCTGCCCTGATTGTGAGACCCAAATGTGTAGGCTCTAAATTCCAGCCA
TCAAATCCAATTCCTGGTGGGGAAAACCTTCTGGAGACCCCCAACCTTCTGATAAAAGAGTCTCTACCTCCAGGGAAAGCCTTCTTACCA
CACTGGCATATCAGATGAAAGCATTGCACTGTACCTCTCGTAACACAGCAATACAGTCCTCTTGAGGCACTCAAGCCTGAGAGGAAGCTC
AGGATCTGACATGTTCTTCCTTTTCCTCACAAGTCATCATGATTTTTTATTTTAAAATAATCTGGAAGTAATGGGAACTTAGTTTTTCCT
GAACTCCAACCAGAATCCAAATTGGTTAGATGAGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGT
GGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTGG
TGGCGCCTGGTTGAGGCATGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCTACTGCACTCCAGCCTGGG
CAACAAAGTGGGACTCTGTCTTAAAAAAAAAAAAAAAAAAAAAATCGGTTAGATGAGAAAGCATGTATATTTTCTATATACAAAAACAAG
AAAGGCGTTTTGAGCCCCTGTGCTCAGGCCCACTCCCACACTGTGGAGTGTACTTTCATTTTCAATAAATCCCCTTATTCCTTCCTTGCA
AAAAAAAAAAAAAAAAAAGCCTTAGCCAGATTCAGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCGGGTGGATCACCTG
AGTTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAAGTAAAAAAAATTAGCCGGGCATGGTGGCTTGT
GCCTTGTAGTCCCAGCCACTGGGGAGGCTGAGGCGGGAGAATTGCTTGAACCTGGGAGGTGGAGATTGCAGTGAGCCGAGATCGCGCCAC
TGCACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAGCCTTAATATTAATGCTAACGTGGCAGAAAACTAGCA
GGTTACATTTTATAGGCTATTGTAGTTTTATTTACCAAATGATATTCTCTAAATCACTTCGACCAATAAATGTATTCTCCTCCTTAAAGC
AGAGTTGTATCAACTCTGTGGGAGCATTTATGAGCTGTCAGTCCCCACACTTCTAGCCAGAATCACAATAAGGTCTGGCTGGGTGTGGGG
TGCTGCATAGGAAAGGGTCTCTGGAGAAGCAAGAAGGGCACAATCATGGCCCACTGCTCCCCTCTTCTTCTCAGTGCTCTTTGCCCTCTC
CTGCTGCGTGCTTCCTCTTCACTCCAGTGCTGATCCTCCTGCTCTCTCTGGCAGCTTCCACCTCACCCGCCCCTCTTCCACACTATAACC
AGTATGGTTGGTGCTGGGGCATTGACTCAGCCCCCCTGCTTTCTGCATTTGTAATAGATATTAATATGATTTCCTAAAACAGAAGATTTT
GTTGCTTTCTTTGAACTTGTATTGAAAACCATACAGTCTCACTGTTTTGCTTTAATTCCTATCCACACTATAAATGGAAGAAAAAAATTA
ATAGCTTCTGTTTAATCTGATGAATGTGGCTTTTTTTCCCTTCACTTTAATGTTCAAGAAGTTGTGGCTATTTCATAGATTTCTTCTGAT
TTATTCTGTGGGTCCCTGTTATCTGTTCTTTATGTAATCTTTCAGTAGATTTTCATCCTTTCATATCCACATTCTTATGTGGACTTGCTG
AAGAAACAGAATATCAGTTCAAAACAAAACCTAGGCCAGGCATGGTGGTTCACGCCTATAATCTCAGCACTTTGGGAAGCCAAGGCGGTC
AGGAGTTTGAGACCAGCCTGACCAACATGATGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCTGGCGTGGTGGCACGCATCTGTA
ATCCCAACTACTCAGGACGCTGAGGCAGGAGAGTCGCTTGAACCCAGGAGGCGGAGATTGCAGTGAGCCAAGATTGCACCACTGCACTCC
AGCCTGGGCAACAGAGCGAGACTCCATCAAAAAAAAAAAAAAAAAAGAAGGAAGGAAGGAAAGCAAGCCCTGAATCCACATCTCCTTGAA
GTTTTTTTTGTTTTATTTTGTTTTTGAGACAGAATTTTGCTCTTGTTGCCCAGGCCGGAGTGCAATGGTGCAATCTCAGCTCACTGCAAC
CTCCGCCTCCCGGGTTGAGGCGATTCTCCTACCTCAGCCTCCCAAGTAGCTAGGATTACAGGCATGAGCCACCACGCCTGGCTAATTTTA
TATTTCTAGTAGAGATGAGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCCGACCTCAGGTGATCCACCCACCTCAGCCTCCCAAA
GTGGTGGGATTACAGGCATGAGCCACCGTGCCGAGCCTTCCTTGAAGTTTTTTGTTTGGTTTTGATTTGTTTTGTTTTGTTTTGTTTTGT
TTTGTTTTTGGAGATAGGGTCTCACTCTGTTACCCATGCTGGAGTGCAGTGGCACAATCTTGGCTCAGAGCAACCTCTGCCTCCCAGGCT
CAAGCAATCCTCCCACTTCAGTCTAAGTAGCTGGGACTACAGGCACGTGCCACCAGGCCCAGCTAATTTTTGTGTTTTGTTAGAGATGAG
GTTTTGCCATATTGCCCAGGCTCGTCTTGAACACCGGGGCTCAAGGAATCTGCCCATCTTCGCCTCCCAAAGTTCTGAGATAGCAGGTGT
GAGTCATCATGCCCAGCCTCCTTGAAGTTTACTAACAATTGGGATAACTGAGGGAAGAGAAGTGACAATTCCACTCAGTCTATTAGAGGT
CTGGATATAAGGTAGCCACACAATAACTCTAACTTGACTTCTAACCATTCTATCTTATTGATTTGGAGGCTGTCTTCTGCCAGATTTTTT
GTGGCTTGAGATGATATTTTCGAACCCTTCTTTCACTACCTTTCTTACCCTTAATGTGCCAAGCTTGAAACAGGATTTGATTTCCTGAGC
TACTTGTTCGCCTTCTGTGCGTCACCAAGTAATCTGGTTCATCTTTCGTCTCATTCATGTTATTTTCAAGTGAAACAAGACATTTTGGGG
GTCAAGTCTCTTTGGGTGTTTTGTTTTTATGTATATAAAAATGGATTTTGTGTTCCCTTTCCATGTAAGTACCAACTTATATGGAAACTC
ACAATCATAATGTAAAGAAGAAATGAAAGCCTGGTGTATTGTACTTCAAGATGCCTCCCTGATGTATAGAATCTCCTTGTAAAATAAATA

>1747_1747_4_ACTN1-PHACTR4_ACTN1_chr14_69387723_ENST00000438964_PHACTR4_chr1_28800066_ENST00000373839_length(amino acids)=541AA_BP=113
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKI
SNVNKALDFIASKGVKLVSIGAEAELSQAINSGTLLSKPSPPLPPKRGIPSTSVPTLESAAAITTKTPSDEREKSTCSMGSELLPMISPR
SPSPPLPTHIPPEPPRTPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPLPM
TPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPSTFSEEMTPTSVIPKLPQCLREEEEKESDSDSEGP
IQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELNLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEAD
RQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHR

--------------------------------------------------------------
>1747_1747_5_ACTN1-PHACTR4_ACTN1_chr14_69387723_ENST00000538545_PHACTR4_chr1_28800066_ENST00000373839_length(transcript)=5466nt_BP=360nt
CCTAGCACGCGCGCACCATCATGGACCATTATGATTCTCAGCAAACCAACGATTACATGCAGCCAGAAGAGGACTGGGACCGGGACCTGC
TCCTGGACCCGGCCTGGGAGAAGCAGCAGAGAAAGACATTCACGGCATGGTGTAACTCCCACCTCCGGAAGGCGGGGACACAGATCGAGA
ACATCGAAGAGGACTTCCGGGATGGCCTGAAGCTCATGCTGCTGCTGGAGGTCATCTCAGGTGAACGCTTGGCCAAGCCAGAGCGAGGCA
AGATGAGAGTGCACAAGATCTCCAACGTCAACAAGGCCCTGGATTTCATAGCCAGCAAAGGCGTCAAACTGGTGTCCATCGGAGCCGAAG
CTGAACTGTCCCAAGCAATAAACAGTGGTACATTGTTATCAAAACCGTCCCCACCCTTACCACCTAAGAGAGGCATTCCATCAACCTCAG
TACCCACCTTGGAGTCTGCTGCTGCCATCACCACAAAAACACCAAGTGATGAAAGAGAGAAGAGCACGTGTTCTATGGGCTCGGAACTAC
TACCAATGATCTCACCTCGCTCTCCGTCCCCCCCACTGCCTACTCATATACCTCCAGAGCCTCCACGCACCCCTCCATTCCCTGCTAAGA
CTTTTCAAGTTGTGCCAGAAATTGAGTTTCCACCATCCTTAGATCTACACCAGGAGATTCCCCAGCAGGAAGATCAGAAAAAGGAAGTCC
CCAAGAGGATACTGGACCAGAACTTTGGGGAGCCCCATATACCCTCTAGGCTGCCTCCACTCCCACTGCATATTCGAATCCAGCAGGCCC
TCACCAGCCCACTTCCCATGACTCCTATTCTGGAGGGTTCTCACAGAGCTCATTCGTTGCTTTTTGAAAACAGTGACAGCTTTTCTGAGG
ACAGCAGTACGCTGGGTCGGACCAGGTCTCTTCCCATCACTATTGAAATGCTAAAAGTTCCAGACGATGAAGAAGAAGAGGAGCAAACCT
GTCCATCCACATTCAGTGAAGAAATGACACCTACCTCAGTCATTCCTAAATTACCACAGTGTCTACGGGAGGAAGAAGAGAAGGAGAGCG
ACTCTGATTCAGAAGGTCCCATTCAGTACCGAGATGAAGAAGATGAAGATGAAAGCTATCAGAGTGCTCTCGCCAACAAAGTGAAGAGGA
AAGACACACTGGCAATGAAGTTGAACCACAGACCCAGTGAACCAGAGTTGAACCTGAATTCTTGGCCTTGTAAAAGCAAGGAGGAGTGGA
ATGAAATACGGCACCAGATTGGAAACACACTGATCCGGCGACTGAGTCAAAGACCAACACCAGAAGAACTAGAACAACGCAATATATTGC
AACCTAAAAATGAAGCTGATCGTCAGGCAGAAAAACGAGAAATTAAACGTCGGCTCACTAGAAAGCTCAGTCAAAGGCCAACTGTCGCTG
AACTCCTTGCCAGGAAGATTCTGAGGTTTAATGAATATGTAGAGGTAACAGATGCTCAAGATTATGACCGGCGAGCCGACAAACCTTGGA
CCAAACTGACCCCTGCTGACAAGGCTGCCATAAGAAAAGAATTAAATGAATTTAAAAGCTCCGAGATGGAGGTTCATGAAGAGAGCAAAC
ATTTTACACGCTACCATCGTCCATGATGCCAAAGGTTGAGAGAGGAATCAACATGGCTGCTTTGCTGCTTCCTTCTCCAAAGTGACATAT
GGAGGGAACTTTAGCACTTCCCAGCACAGCCAGAATTGCATCCTCTGGGATCTTCTGAGGTGGACAGCACTTTGAATGTAGCATTTCACT
GGAACAGAGTCTTATGTGCTGCACCGGGGGCAAAACAACACTTTGTCAGTGCTTTTGAACCTTTCAATATTGTAGCATGCTTGAGGAGTT
TTTCCCTTACTGGCCACCAAAGTTCTGAACCACTTGCAGGTTCCAGGTTTTACTGGCTGCACCACACCCCTTCCCCTAGATGACTGCCTG
TGCAGAGACACAGTTTGCACCATTAGCCTTACCTGCCCTGCCCTGATTGTGAGACCCAAATGTGTAGGCTCTAAATTCCAGCCATCAAAT
CCAATTCCTGGTGGGGAAAACCTTCTGGAGACCCCCAACCTTCTGATAAAAGAGTCTCTACCTCCAGGGAAAGCCTTCTTACCACACTGG
CATATCAGATGAAAGCATTGCACTGTACCTCTCGTAACACAGCAATACAGTCCTCTTGAGGCACTCAAGCCTGAGAGGAAGCTCAGGATC
TGACATGTTCTTCCTTTTCCTCACAAGTCATCATGATTTTTTATTTTAAAATAATCTGGAAGTAATGGGAACTTAGTTTTTCCTGAACTC
CAACCAGAATCCAAATTGGTTAGATGAGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCA
CCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCGC
CTGGTTGAGGCATGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCTACTGCACTCCAGCCTGGGCAACAA
AGTGGGACTCTGTCTTAAAAAAAAAAAAAAAAAAAAAATCGGTTAGATGAGAAAGCATGTATATTTTCTATATACAAAAACAAGAAAGGC
GTTTTGAGCCCCTGTGCTCAGGCCCACTCCCACACTGTGGAGTGTACTTTCATTTTCAATAAATCCCCTTATTCCTTCCTTGCAAAAAAA
AAAAAAAAAAAAGCCTTAGCCAGATTCAGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGTTCA
GGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAAGTAAAAAAAATTAGCCGGGCATGGTGGCTTGTGCCTTG
TAGTCCCAGCCACTGGGGAGGCTGAGGCGGGAGAATTGCTTGAACCTGGGAGGTGGAGATTGCAGTGAGCCGAGATCGCGCCACTGCACT
CCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAGCCTTAATATTAATGCTAACGTGGCAGAAAACTAGCAGGTTAC
ATTTTATAGGCTATTGTAGTTTTATTTACCAAATGATATTCTCTAAATCACTTCGACCAATAAATGTATTCTCCTCCTTAAAGCAGAGTT
GTATCAACTCTGTGGGAGCATTTATGAGCTGTCAGTCCCCACACTTCTAGCCAGAATCACAATAAGGTCTGGCTGGGTGTGGGGTGCTGC
ATAGGAAAGGGTCTCTGGAGAAGCAAGAAGGGCACAATCATGGCCCACTGCTCCCCTCTTCTTCTCAGTGCTCTTTGCCCTCTCCTGCTG
CGTGCTTCCTCTTCACTCCAGTGCTGATCCTCCTGCTCTCTCTGGCAGCTTCCACCTCACCCGCCCCTCTTCCACACTATAACCAGTATG
GTTGGTGCTGGGGCATTGACTCAGCCCCCCTGCTTTCTGCATTTGTAATAGATATTAATATGATTTCCTAAAACAGAAGATTTTGTTGCT
TTCTTTGAACTTGTATTGAAAACCATACAGTCTCACTGTTTTGCTTTAATTCCTATCCACACTATAAATGGAAGAAAAAAATTAATAGCT
TCTGTTTAATCTGATGAATGTGGCTTTTTTTCCCTTCACTTTAATGTTCAAGAAGTTGTGGCTATTTCATAGATTTCTTCTGATTTATTC
TGTGGGTCCCTGTTATCTGTTCTTTATGTAATCTTTCAGTAGATTTTCATCCTTTCATATCCACATTCTTATGTGGACTTGCTGAAGAAA
CAGAATATCAGTTCAAAACAAAACCTAGGCCAGGCATGGTGGTTCACGCCTATAATCTCAGCACTTTGGGAAGCCAAGGCGGTCAGGAGT
TTGAGACCAGCCTGACCAACATGATGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCTGGCGTGGTGGCACGCATCTGTAATCCCA
ACTACTCAGGACGCTGAGGCAGGAGAGTCGCTTGAACCCAGGAGGCGGAGATTGCAGTGAGCCAAGATTGCACCACTGCACTCCAGCCTG
GGCAACAGAGCGAGACTCCATCAAAAAAAAAAAAAAAAAAGAAGGAAGGAAGGAAAGCAAGCCCTGAATCCACATCTCCTTGAAGTTTTT
TTTGTTTTATTTTGTTTTTGAGACAGAATTTTGCTCTTGTTGCCCAGGCCGGAGTGCAATGGTGCAATCTCAGCTCACTGCAACCTCCGC
CTCCCGGGTTGAGGCGATTCTCCTACCTCAGCCTCCCAAGTAGCTAGGATTACAGGCATGAGCCACCACGCCTGGCTAATTTTATATTTC
TAGTAGAGATGAGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCCGACCTCAGGTGATCCACCCACCTCAGCCTCCCAAAGTGGTG
GGATTACAGGCATGAGCCACCGTGCCGAGCCTTCCTTGAAGTTTTTTGTTTGGTTTTGATTTGTTTTGTTTTGTTTTGTTTTGTTTTGTT
TTTGGAGATAGGGTCTCACTCTGTTACCCATGCTGGAGTGCAGTGGCACAATCTTGGCTCAGAGCAACCTCTGCCTCCCAGGCTCAAGCA
ATCCTCCCACTTCAGTCTAAGTAGCTGGGACTACAGGCACGTGCCACCAGGCCCAGCTAATTTTTGTGTTTTGTTAGAGATGAGGTTTTG
CCATATTGCCCAGGCTCGTCTTGAACACCGGGGCTCAAGGAATCTGCCCATCTTCGCCTCCCAAAGTTCTGAGATAGCAGGTGTGAGTCA
TCATGCCCAGCCTCCTTGAAGTTTACTAACAATTGGGATAACTGAGGGAAGAGAAGTGACAATTCCACTCAGTCTATTAGAGGTCTGGAT
ATAAGGTAGCCACACAATAACTCTAACTTGACTTCTAACCATTCTATCTTATTGATTTGGAGGCTGTCTTCTGCCAGATTTTTTGTGGCT
TGAGATGATATTTTCGAACCCTTCTTTCACTACCTTTCTTACCCTTAATGTGCCAAGCTTGAAACAGGATTTGATTTCCTGAGCTACTTG
TTCGCCTTCTGTGCGTCACCAAGTAATCTGGTTCATCTTTCGTCTCATTCATGTTATTTTCAAGTGAAACAAGACATTTTGGGGGTCAAG
TCTCTTTGGGTGTTTTGTTTTTATGTATATAAAAATGGATTTTGTGTTCCCTTTCCATGTAAGTACCAACTTATATGGAAACTCACAATC
ATAATGTAAAGAAGAAATGAAAGCCTGGTGTATTGTACTTCAAGATGCCTCCCTGATGTATAGAATCTCCTTGTAAAATAAATAATTGCA

>1747_1747_5_ACTN1-PHACTR4_ACTN1_chr14_69387723_ENST00000538545_PHACTR4_chr1_28800066_ENST00000373839_length(amino acids)=541AA_BP=113
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKI
SNVNKALDFIASKGVKLVSIGAEAELSQAINSGTLLSKPSPPLPPKRGIPSTSVPTLESAAAITTKTPSDEREKSTCSMGSELLPMISPR
SPSPPLPTHIPPEPPRTPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPLPM
TPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPSTFSEEMTPTSVIPKLPQCLREEEEKESDSDSEGP
IQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELNLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEAD
RQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACTN1-PHACTR4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneACTN1chr14:69387723chr1:28800066ENST00000193403-321274_733113.33333333333333893.0DDN
HgeneACTN1chr14:69387723chr1:28800066ENST00000394419-322274_733113.33333333333333915.0DDN
HgeneACTN1chr14:69387723chr1:28800066ENST00000438964-321274_733113.33333333333333888.0DDN
HgeneACTN1chr14:69387723chr1:28800066ENST00000538545-321274_733113.33333333333333931.0DDN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACTN1-PHACTR4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneACTN1P12814DB06773Human calcitoninIncorporation into and destabilizationBiotechApproved|Investigational
HgeneACTN1P12814DB09130CopperSmall moleculeApproved|Investigational

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Related Diseases for ACTN1-PHACTR4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACTN1C3554663BLEEDING DISORDER, PLATELET-TYPE, 153CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneACTN1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneACTN1C4304021Autosomal dominant macrothrombocytopenia1ORPHANET