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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:DLEU2-HMGB1 (FusionGDB2 ID:HG8847TG3146) |
Fusion Gene Summary for DLEU2-HMGB1 |
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Fusion gene information | Fusion gene name: DLEU2-HMGB1 | Fusion gene ID: hg8847tg3146 | Hgene | Tgene | Gene symbol | DLEU2 | HMGB1 | Gene ID | 8847 | 3146 |
Gene name | deleted in lymphocytic leukemia 2 | high mobility group box 1 | |
Synonyms | ALT1|BCMSUN|DLB2|LEU2|LINC00022|MIR15AHG|NCRNA00022|RFP2|RFP2OS|TRIM13OS | HMG-1|HMG1|HMG3|SBP-1 | |
Cytomap | ('DLEU2')('HMGB1') 13q14.2 | 13q12.3 | |
Type of gene | ncRNA | protein-coding | |
Description | deleted in lymphocytic leukemia 2 (non-protein coding)leukemia associated gene 2long intergenic non-protein coding RNA 22mir-15a-16-1 cluster host gene (non-protein coding)ret finger protein 2 opposite strand | high mobility group protein B1AmphoterinSulfoglucuronyl carbohydrate binding proteinhigh-mobility group (nonhistone chromosomal) protein 1 | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000607334, | ||
Fusion gene scores | * DoF score | 19 X 11 X 9=1881 | 28 X 10 X 6=1680 |
# samples | 20 | 21 | |
** MAII score | log2(20/1881*10)=-3.23342794374847 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(21/1680*10)=-3 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DLEU2 [Title/Abstract] AND HMGB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DLEU2(50699438)-HMGB1(31037831), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | HMGB1 | GO:0002218 | activation of innate immune response | 24971542 |
Tgene | HMGB1 | GO:0002643 | regulation of tolerance induction | 18631454 |
Tgene | HMGB1 | GO:0006357 | regulation of transcription by RNA polymerase II | 11748232 |
Tgene | HMGB1 | GO:0006954 | inflammatory response | 23146691 |
Tgene | HMGB1 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 22370717 |
Tgene | HMGB1 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly | 8006019 |
Tgene | HMGB1 | GO:0032072 | regulation of restriction endodeoxyribonuclease activity | 17803946 |
Tgene | HMGB1 | GO:0032425 | positive regulation of mismatch repair | 15014079 |
Tgene | HMGB1 | GO:0032689 | negative regulation of interferon-gamma production | 22473704 |
Tgene | HMGB1 | GO:0032733 | positive regulation of interleukin-10 production | 22473704 |
Tgene | HMGB1 | GO:0032755 | positive regulation of interleukin-6 production | 26961863 |
Tgene | HMGB1 | GO:0032757 | positive regulation of interleukin-8 production | 26961863 |
Tgene | HMGB1 | GO:0033151 | V(D)J recombination | 9166431 |
Tgene | HMGB1 | GO:0035711 | T-helper 1 cell activation | 22473704 |
Tgene | HMGB1 | GO:0043065 | positive regulation of apoptotic process | 19800306 |
Tgene | HMGB1 | GO:0043277 | apoptotic cell clearance | 18768881 |
Tgene | HMGB1 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 19800306 |
Tgene | HMGB1 | GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation | 22473704 |
Tgene | HMGB1 | GO:0043388 | positive regulation of DNA binding | 11748232|19223331 |
Tgene | HMGB1 | GO:0043410 | positive regulation of MAPK cascade | 12765338 |
Tgene | HMGB1 | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 23148224 |
Tgene | HMGB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19223331 |
Tgene | HMGB1 | GO:0046330 | positive regulation of JNK cascade | 12765338 |
Tgene | HMGB1 | GO:0050716 | positive regulation of interleukin-1 secretion | 12765338 |
Tgene | HMGB1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22370717 |
Tgene | HMGB1 | GO:0090026 | positive regulation of monocyte chemotaxis | 22370717 |
Tgene | HMGB1 | GO:0097350 | neutrophil clearance | 18768881 |
Tgene | HMGB1 | GO:1990774 | tumor necrosis factor secretion | 12765338 |
Tgene | HMGB1 | GO:2000343 | positive regulation of chemokine (C-X-C motif) ligand 2 production | 26961863 |
Tgene | HMGB1 | GO:2000426 | negative regulation of apoptotic cell clearance | 20826760 |
Tgene | HMGB1 | GO:2000778 | positive regulation of interleukin-6 secretion | 12765338 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | ERR315333 | DLEU2 | chr13 | 50699438 | - | HMGB1 | chr13 | 31037831 | - |
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Fusion Gene ORF analysis for DLEU2-HMGB1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000607334 | ENST00000326004 | DLEU2 | chr13 | 50699438 | - | HMGB1 | chr13 | 31037831 | - |
intron-5UTR | ENST00000607334 | ENST00000339872 | DLEU2 | chr13 | 50699438 | - | HMGB1 | chr13 | 31037831 | - |
intron-5UTR | ENST00000607334 | ENST00000341423 | DLEU2 | chr13 | 50699438 | - | HMGB1 | chr13 | 31037831 | - |
intron-5UTR | ENST00000607334 | ENST00000399489 | DLEU2 | chr13 | 50699438 | - | HMGB1 | chr13 | 31037831 | - |
intron-5UTR | ENST00000607334 | ENST00000399494 | DLEU2 | chr13 | 50699438 | - | HMGB1 | chr13 | 31037831 | - |
intron-5UTR | ENST00000607334 | ENST00000405805 | DLEU2 | chr13 | 50699438 | - | HMGB1 | chr13 | 31037831 | - |
intron-5UTR | ENST00000607334 | ENST00000468384 | DLEU2 | chr13 | 50699438 | - | HMGB1 | chr13 | 31037831 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DLEU2-HMGB1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for DLEU2-HMGB1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:50699438/:31037831) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DLEU2-HMGB1 |
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Fusion Gene PPI Analysis for DLEU2-HMGB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DLEU2-HMGB1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DLEU2-HMGB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DLEU2 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | DLEU2 | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human |
Hgene | DLEU2 | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human |
Tgene | C0021368 | Inflammation | 5 | CTD_human | |
Tgene | C0027540 | Necrosis | 2 | CTD_human | |
Tgene | C0034189 | Pyemia | 2 | CTD_human | |
Tgene | C0036690 | Septicemia | 2 | CTD_human | |
Tgene | C0243026 | Sepsis | 2 | CTD_human | |
Tgene | C1719672 | Severe Sepsis | 2 | CTD_human | |
Tgene | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET | |
Tgene | C0005398 | Cholestasis, Extrahepatic | 1 | CTD_human | |
Tgene | C0013221 | Drug toxicity | 1 | CTD_human | |
Tgene | C0015967 | Fever | 1 | CTD_human | |
Tgene | C0019193 | Hepatitis, Toxic | 1 | CTD_human | |
Tgene | C0020429 | Hyperalgesia | 1 | CTD_human | |
Tgene | C0026766 | Multiple Organ Failure | 1 | CTD_human | |
Tgene | C0027051 | Myocardial Infarction | 1 | CTD_human | |
Tgene | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human | |
Tgene | C0027796 | Neuralgia | 1 | CTD_human | |
Tgene | C0034069 | Pulmonary Fibrosis | 1 | CTD_human | |
Tgene | C0038870 | Neuralgia, Supraorbital | 1 | CTD_human | |
Tgene | C0041755 | Adverse reaction to drug | 1 | CTD_human | |
Tgene | C0042656 | Neuralgia, Vidian | 1 | CTD_human | |
Tgene | C0151744 | Myocardial Ischemia | 1 | CTD_human | |
Tgene | C0234247 | Neuralgia, Atypical | 1 | CTD_human | |
Tgene | C0234249 | Neuralgia, Stump | 1 | CTD_human | |
Tgene | C0264939 | Systemic Vasculitis | 1 | CTD_human | |
Tgene | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human | |
Tgene | C0282548 | Leukostasis | 1 | CTD_human | |
Tgene | C0423711 | Neuralgia, Perineal | 1 | CTD_human | |
Tgene | C0423712 | Neuralgia, Iliohypogastric Nerve | 1 | CTD_human | |
Tgene | C0458247 | Allodynia | 1 | CTD_human | |
Tgene | C0751211 | Hyperalgesia, Primary | 1 | CTD_human | |
Tgene | C0751212 | Hyperalgesia, Secondary | 1 | CTD_human | |
Tgene | C0751213 | Tactile Allodynia | 1 | CTD_human | |
Tgene | C0751214 | Hyperalgesia, Thermal | 1 | CTD_human | |
Tgene | C0751371 | Neuralgia, Ilioinguinal | 1 | CTD_human | |
Tgene | C0751372 | Nerve Pain | 1 | CTD_human | |
Tgene | C0751373 | Paroxysmal Nerve Pain | 1 | CTD_human | |
Tgene | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human | |
Tgene | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human | |
Tgene | C1850383 | Neuropathy, Painful | 1 | CTD_human | |
Tgene | C2936719 | Mechanical Allodynia | 1 | CTD_human | |
Tgene | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human | |
Tgene | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human | |
Tgene | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human | |
Tgene | C4721507 | Alveolitis, Fibrosing | 1 | CTD_human |