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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KAT2B-KANSL1 (FusionGDB2 ID:HG8850TG284058)

Fusion Gene Summary for KAT2B-KANSL1

check button Fusion gene summary
Fusion gene informationFusion gene name: KAT2B-KANSL1
Fusion gene ID: hg8850tg284058
HgeneTgene
Gene symbol

KAT2B

KANSL1

Gene ID

8850

284058

Gene namelysine acetyltransferase 2BKAT8 regulatory NSL complex subunit 1
SynonymsCAF|P/CAF|PCAFCENP-36|KDVS|KIAA1267|MSL1v1|NSL1|hMSL1v1
Cytomap('KAT2B')('KANSL1')

3p24.3

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT2BCREBBP-associated factorK(lysine) acetyltransferase 2Bhistone acetylase PCAFhistone acetyltransferase PCAFp300/CBP-associated factorspermidine acetyltransferase KAT2BKAT8 regulatory NSL complex subunit 1MLL1/MLL complex subunit KANSL1MSL1 homolog 1NSL complex protein NSL1centromere protein 36male-specific lethal 1 homolognon-specific lethal 1 homolog
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000426228, ENST00000263754, 
Fusion gene scores* DoF score4 X 4 X 2=3217 X 18 X 11=3366
# samples 428
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(28/3366*10)=-3.58753644438498
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KAT2B [Title/Abstract] AND KANSL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKAT2B(20136900)-KANSL1(44145033), # samples:1
Anticipated loss of major functional domain due to fusion event.KAT2B-KANSL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT2B-KANSL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT2B-KANSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT2B-KANSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT2B

GO:0006338

chromatin remodeling

17707232

HgeneKAT2B

GO:0006473

protein acetylation

15273251|26867678

HgeneKAT2B

GO:0008285

negative regulation of cell proliferation

8684459

HgeneKAT2B

GO:0010835

regulation of protein ADP-ribosylation

19470756

HgeneKAT2B

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

HgeneKAT2B

GO:0018393

internal peptidyl-lysine acetylation

23932781|27796307|29174768

HgeneKAT2B

GO:0018394

peptidyl-lysine acetylation

19303849|19470756

HgeneKAT2B

GO:0032869

cellular response to insulin stimulus

19303849

HgeneKAT2B

GO:0043966

histone H3 acetylation

18838386

HgeneKAT2B

GO:0045944

positive regulation of transcription by RNA polymerase II

19470756

HgeneKAT2B

GO:0046600

negative regulation of centriole replication

27796307

HgeneKAT2B

GO:2000233

negative regulation of rRNA processing

26867678

TgeneKANSL1

GO:0043981

histone H4-K5 acetylation

20018852

TgeneKANSL1

GO:0043982

histone H4-K8 acetylation

20018852

TgeneKANSL1

GO:0043984

histone H4-K16 acetylation

20018852


check buttonFusion gene breakpoints across KAT2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KANSL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315398KAT2Bchr3

20136900

+KANSL1chr17

44145033

-


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Fusion Gene ORF analysis for KAT2B-KANSL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000426228ENST00000262419KAT2Bchr3

20136900

+KANSL1chr17

44145033

-
3UTR-3CDSENST00000426228ENST00000432791KAT2Bchr3

20136900

+KANSL1chr17

44145033

-
3UTR-3CDSENST00000426228ENST00000572904KAT2Bchr3

20136900

+KANSL1chr17

44145033

-
3UTR-3CDSENST00000426228ENST00000574590KAT2Bchr3

20136900

+KANSL1chr17

44145033

-
3UTR-3CDSENST00000426228ENST00000575318KAT2Bchr3

20136900

+KANSL1chr17

44145033

-
3UTR-5UTRENST00000426228ENST00000393476KAT2Bchr3

20136900

+KANSL1chr17

44145033

-
3UTR-intronENST00000426228ENST00000576248KAT2Bchr3

20136900

+KANSL1chr17

44145033

-
5CDS-5UTRENST00000263754ENST00000393476KAT2Bchr3

20136900

+KANSL1chr17

44145033

-
5CDS-intronENST00000263754ENST00000576248KAT2Bchr3

20136900

+KANSL1chr17

44145033

-
In-frameENST00000263754ENST00000262419KAT2Bchr3

20136900

+KANSL1chr17

44145033

-
In-frameENST00000263754ENST00000432791KAT2Bchr3

20136900

+KANSL1chr17

44145033

-
In-frameENST00000263754ENST00000572904KAT2Bchr3

20136900

+KANSL1chr17

44145033

-
In-frameENST00000263754ENST00000574590KAT2Bchr3

20136900

+KANSL1chr17

44145033

-
In-frameENST00000263754ENST00000575318KAT2Bchr3

20136900

+KANSL1chr17

44145033

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263754KAT2Bchr320136900+ENST00000574590KANSL1chr1744145033-437610314552815786
ENST00000263754KAT2Bchr320136900+ENST00000575318KANSL1chr1744145033-417510314552623722
ENST00000263754KAT2Bchr320136900+ENST00000572904KANSL1chr1744145033-433910314552815786
ENST00000263754KAT2Bchr320136900+ENST00000262419KANSL1chr1744145033-433610314552815786
ENST00000263754KAT2Bchr320136900+ENST00000432791KANSL1chr1744145033-432410314552815786

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263754ENST00000574590KAT2Bchr320136900+KANSL1chr1744145033-0.0071104660.9928895
ENST00000263754ENST00000575318KAT2Bchr320136900+KANSL1chr1744145033-0.0108965750.98910344
ENST00000263754ENST00000572904KAT2Bchr320136900+KANSL1chr1744145033-0.0078920.9921079
ENST00000263754ENST00000262419KAT2Bchr320136900+KANSL1chr1744145033-0.0078599410.9921401
ENST00000263754ENST00000432791KAT2Bchr320136900+KANSL1chr1744145033-0.0084442780.99155575

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Fusion Genomic Features for KAT2B-KANSL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for KAT2B-KANSL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:20136900/chr17:44145033)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKANSL1chr3:20136900chr17:44145033ENST00000262419315850_8825111106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
TgeneKANSL1chr3:20136900chr17:44145033ENST00000432791214850_8825111106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
TgeneKANSL1chr3:20136900chr17:44145033ENST00000572904315850_8825111106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
TgeneKANSL1chr3:20136900chr17:44145033ENST00000574590315850_8825111106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT2Bchr3:20136900chr17:44145033ENST00000263754+318503_651192833.0DomainN-acetyltransferase
HgeneKAT2Bchr3:20136900chr17:44145033ENST00000263754+318740_810192833.0DomainBromo
HgeneKAT2Bchr3:20136900chr17:44145033ENST00000263754+318574_576192833.0RegionAcetyl-CoA binding
HgeneKAT2Bchr3:20136900chr17:44145033ENST00000263754+318581_587192833.0RegionAcetyl-CoA binding
HgeneKAT2Bchr3:20136900chr17:44145033ENST00000263754+318612_615192833.0RegionAcetyl-CoA binding
TgeneKANSL1chr3:20136900chr17:44145033ENST00000262419315283_3145111106.0Coiled coilOntology_term=ECO:0000255
TgeneKANSL1chr3:20136900chr17:44145033ENST00000432791214283_3145111106.0Coiled coilOntology_term=ECO:0000255
TgeneKANSL1chr3:20136900chr17:44145033ENST00000572904315283_3145111106.0Coiled coilOntology_term=ECO:0000255
TgeneKANSL1chr3:20136900chr17:44145033ENST00000574590315283_3145111106.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for KAT2B-KANSL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41186_41186_1_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000262419_length(transcript)=4336nt_BP=1031nt
CCGCGGGCAGCGGAAAAGAGGCCGTGGGGGGCCTCCCAGCGCTGGCAGACACCGTGAGGCTGGCAGCCGCCGGCACGCACACCTAGTCCG
CAGTCCCGAGGAACATGTCCGCAGCCAGGGCGCGGAGCAGAGTCCCGGGCAGGAGAACCAAGGGAGGGCGTGTGCTGTGGCGGCGGCGGC
AGCGGCAGCGGAGCCGCTAGTCCCCTCCCTCCTGGGGGAGCAGCTGCCGCCGCTGCCGCCGCCGCCACCACCATCAGCGCGCGGGGCCCG
GCCAGAGCGAGCCGGGCGAGCGGCGCGCTAGGGGGAGGGCGGGGGCGGGGAGGGGGGTGGGCGAAGGGGGCGGGAGGGCGTGGGGGGAGG
GTCTCGCTCTCCCGACTACCAGAGCCCGAGAGGGAGACCCTGGCGGCGGCGGCGGCGCCTGACACTCGGCGCCTCCTGCCGTGCTCCGGG
GCGGCATGTCCGAGGCTGGCGGGGCCGGGCCGGGCGGCTGCGGGGCAGGAGCCGGGGCAGGGGCCGGGCCCGGGGCGCTGCCCCCGCAGC
CTGCGGCGCTTCCGCCCGCGCCCCCGCAGGGCTCCCCCTGCGCCGCTGCCGCCGGGGGCTCGGGCGCCTGCGGTCCGGCGACGGCAGTGG
CTGCAGCGGGCACGGCCGAAGGACCGGGAGGCGGTGGCTCGGCCCGAATCGCCGTGAAGAAAGCGCAACTACGCTCCGCTCCGCGGGCCA
AGAAACTGGAGAAACTCGGAGTGTACTCCGCCTGCAAGGCCGAGGAGTCTTGTAAATGTAATGGCTGGAAAAACCCTAACCCCTCACCCA
CTCCCCCCAGAGCCGACCTGCAGCAAATAATTGTCAGTCTAACAGAATCCTGTCGGAGTTGTAGCCATGCCCTAGCTGCTCATGTTTCCC
ACCTGGAGAATGTGTCAGAGGAAGAAATGAACAGACTCCTGGGAATAGTATTGGATGTGGAATATCTCTTTACCTGTGTCCACAAGGAAG
AAGATGCAGATACCAAACAAGTTTATTTCTATCTATTTAAGATTGAGTCTGTTTCTCAGCCATTGGAAAACCATGGTGCCCGTATTATTG
GTCATATTTCAGAGTCACTGTCTACCAAATCATGTGGAGCACTCAGACCTGTCAATGGAGTTATTAACACTCTTCAGCCTGTCTTGGCAG
ACCACATTCCAGGTGACAGCTCTGATGCTGAGGAACAATTACATAAGAAGCAACGACTGAATCTCGTCTCTTCATCATCTGATGGCACCT
GTGTGGCAGCCCGGACACGTCCTGTACTGAGCTGTAAGAAGCGGAGGCTTGTTCGACCCAACAGCATCGTTCCTCTTTCCAAGAAGGTTC
ACCGGAACAGCACAATCCGCCCTGGCTGTGATGTGAATCCCTCCTGCGCACTGTGTGGTTCAGGCAGCATCAACACCATGCCTCCCGAAA
TTCACTATGAAGCCCCTCTGTTGGAACGTCTTTCCCAGTTGGACTCTTGTGTTCATCCTGTTCTAGCATTTCCAGATGATGTTCCCACAA
GCCTGCATTTCCAGAGCATGCTGAAATCTCAGTGGCAGAACAAGCCTTTTGACAAAATCAAACCTCCCAAAAAGTTATCGCTTAAGCACA
GAGCACCCATGCCGGGCAGTCTGCCAGATTCAGCTCGTAAGGACAGGCACAAATTGGTCAGCTCCTTCCTAACAACAGCCAAGCTGTCCC
ATCACCAAACCCGGCCTGACAGGACCCACAGGCAGCACTTAGACGATGTGGGGGCCGTGCCCATGGTGGAGCGAGTGACAGCGCCAAAAG
CAGAGCGCTTGCTCAACCCACCACCACCCGTGCATGACCCAAACCACAGCAAAATGAGATTGCGAGACCATTCATCTGAGAGAAGTGAAG
TGTTGAAGCATCACACAGACATGAGCAGTTCGAGCTACTTGGCAGCCACCCACCATCCTCCACACAGTCCCTTGGTGCGACAGCTCTCCA
CCTCCTCAGATTCCCCTGCACCCGCCAGCTCTAGCTCACAGGTTACAGCCAGCACATCGCAGCAGCCAGTAAGGAGGAGAAGGGGAGAGA
GCTCATTTGATATTAACAACATTGTCATCCCAATGTCTGTTGCTGCAACAACTCGCGTAGAGAAACTGCAATACAAGGAAATCCTTACGC
CCAGCTGGCGGGAGGTTGATCTTCAGTCTCTGAAGGGGAGTCCTGATGAGGAGAATGAAGAGATTGAGGACCTATCCGACGCAGCCTTCG
CCGCCCTGCATGCCAAATGTGAGGAGATGGAGAGGGCACGGTGGCTGTGGACCACGAGTGTGCCACCCCAGCGGCGGGGCAGCAGGTCCT
ACAGGTCATCAGACGGCCGGACAACCCCCCAGCTGGGCAGTGCCAACCCCTCCACCCCCCAGCCTGCCTCCCCTGATGTCAGCAGTAGCC
ACTCTTTGTCAGAATACTCCCATGGTCAGTCCCCTAGGAGCCCCATTAGCCCGGAACTGCACTCAGCACCCCTCACCCCTGTGGCTCGGG
ACACTCCGCGACACTTAGCCAGTGAGGATACCCGTTGTTCCACACCAGAGCTGGGGCTGGATGAACAGTCTGTCCAGCCCTGGGAGCGGC
GGACCTTCCCCCTGGCGCACAGTCCCCAGGCGGAGTGTGAGGACCAGCTGGATGCACAGGAGCGAGCAGCCCGCTGCACTCGACGCACCT
CAGGCAGCAAGACTGGCCGGGAGACAGAGGCAGCGCCCACCTCGCCTCCCATTGTCCCCCTCAAGAGTCGGCATCTGGTGGCAGCAGCCA
CAGCTCAGCGCCCGACTCACAGATGAGCGGGAGACAGCCATCTAAACAGACTCACTAACTATTGGCATTAAAGCTTCAGAAATCTCTGCG
TTTGATATTCAAACATCATATGCCGGAAATTTTCACAGTTTTTAGTGAACTTAAGGAATTTAGATCCTACTTTGGTATTTTTTTTTCTTG
TTTTAATTTTTGTTTTGTTTTTGTTTCCATGTTTTCTTGTCACACACCTGAGCACTTCCTCCCGTTGGCAAACAGAAGTTCAGGATGAGA
CCCTGCTGGCCTGGTCCTGGCACATCCTCTGCACTGTTGAATCACTGGACTTACTGATCTTAGATGACCACCCCCTCCCTCACACCTGTG
GGCAGGGCAGAACAGCCTGGCGGGCTACAGTTTAGCATGGCCTTCTTGAGCTAGGGTGGAATGGGGCAGGGTGCTCTGGACTCTTACCCC
CTCCCCTCCCATCTGTGGCTTGGCTCTGCTGTGGCCCTCCTGGCTGGGTCCCCTTGGTTTTTCGTGCTGGAACATCCCCACCAGAGCCTC
TCTGCCATAACTGCCAGCTGCTCTCCCCGAGTGCTCAGCTGGCAGAACACCTTTCCTTTCTCACCCAGAACTTAAGAGACTGATTTTTTG
TTTCATCTGCATTTGGTCTTCTCTGTTTTGACTCTTTCACTGCAGTAACCTGGCTGTGGCTGCTCAGGTTCCCCTCCTCATGCCCCTTGG
TACCCTTCCCTGTCTGCTCTCCCATGCCATGTACACACCCACAACCCGTCCTTCCACTTGGAATATTTTTACCACCTATCCTGATCTTTG
AAGGTAGGGTTAGGACTACTTAACCTCTATTCCCACTCCCCTGCAAACTGGGGGTTGTGGGAAGTGAGCAGCCATCTCCCTGTGTGATTT
TTTTTTTTTTTCCCTCTGATTCACTTTGCCATGTTTCCTTCACATCCAGATCCCTGTCGGTGTTAGTTCCACTCTTGGTCTTTCACGCTC
CCCTTGCCTGTGGAACATTGTCTGGTCCTAGCTGTGGTTCCCATTGTTCCCCCTTCACCCTTCTCTGTTAACCTTGTGCCTGTCTCCTGT
ATGATCACATCACCAAAAAGGGGGAGGGGGGAGAAGACTCTTTTTTTTTGGCCATTTTGTAATCGTATAAAAATAGTAGACAACTGCTTA
ATGGTTGGGGTTTTTTCACAATTTTCAACATTAGTGATTTTTTTTTCTGTTTGCAAGTTAAAGGGTTTGTCATTGTTTCTTTAAAAAAAA
ATACAATAATGCACCATATCCCTATGCATAAAGTGCTTCTTCTATTTATAAGGTTGAAAATTCTGAATAACCCTTTTAGCATTGAAAAAA
AAAACAAAAACAAAAAATGGAAAAAAAAAACCTTGTATTTTGTAAATATTTTCTTTTCCTGCTTTGGAGCTGTGTAATGGCAGCGAAACA
TGTAGCTGTCTTTGTTCTATAGAAATGCTTTTCTTCAGAGAAGCTGATCTTTGTTAATGTCTTGATTCTGTTCGCAAAGCACAGACTAGT
GCTTAAAAAAAAAAAA

>41186_41186_1_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000262419_length(amino acids)=786AA_BP=192
MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKK
LEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKIESVSQPLENHGARIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCV
AARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSL
HFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAKLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAE
RLLNPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDSPAPASSSSQVTASTSQQPVRRRRGESS
FDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYR
SSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHLASEDTRCSTPELGLDEQSVQPWERRT
FPLAHSPQAECEDQLDAQERAARCTRRTSGSKTGRETEAAPTSPPIVPLKSRHLVAAATAQRPTHR

--------------------------------------------------------------
>41186_41186_2_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000432791_length(transcript)=4324nt_BP=1031nt
CCGCGGGCAGCGGAAAAGAGGCCGTGGGGGGCCTCCCAGCGCTGGCAGACACCGTGAGGCTGGCAGCCGCCGGCACGCACACCTAGTCCG
CAGTCCCGAGGAACATGTCCGCAGCCAGGGCGCGGAGCAGAGTCCCGGGCAGGAGAACCAAGGGAGGGCGTGTGCTGTGGCGGCGGCGGC
AGCGGCAGCGGAGCCGCTAGTCCCCTCCCTCCTGGGGGAGCAGCTGCCGCCGCTGCCGCCGCCGCCACCACCATCAGCGCGCGGGGCCCG
GCCAGAGCGAGCCGGGCGAGCGGCGCGCTAGGGGGAGGGCGGGGGCGGGGAGGGGGGTGGGCGAAGGGGGCGGGAGGGCGTGGGGGGAGG
GTCTCGCTCTCCCGACTACCAGAGCCCGAGAGGGAGACCCTGGCGGCGGCGGCGGCGCCTGACACTCGGCGCCTCCTGCCGTGCTCCGGG
GCGGCATGTCCGAGGCTGGCGGGGCCGGGCCGGGCGGCTGCGGGGCAGGAGCCGGGGCAGGGGCCGGGCCCGGGGCGCTGCCCCCGCAGC
CTGCGGCGCTTCCGCCCGCGCCCCCGCAGGGCTCCCCCTGCGCCGCTGCCGCCGGGGGCTCGGGCGCCTGCGGTCCGGCGACGGCAGTGG
CTGCAGCGGGCACGGCCGAAGGACCGGGAGGCGGTGGCTCGGCCCGAATCGCCGTGAAGAAAGCGCAACTACGCTCCGCTCCGCGGGCCA
AGAAACTGGAGAAACTCGGAGTGTACTCCGCCTGCAAGGCCGAGGAGTCTTGTAAATGTAATGGCTGGAAAAACCCTAACCCCTCACCCA
CTCCCCCCAGAGCCGACCTGCAGCAAATAATTGTCAGTCTAACAGAATCCTGTCGGAGTTGTAGCCATGCCCTAGCTGCTCATGTTTCCC
ACCTGGAGAATGTGTCAGAGGAAGAAATGAACAGACTCCTGGGAATAGTATTGGATGTGGAATATCTCTTTACCTGTGTCCACAAGGAAG
AAGATGCAGATACCAAACAAGTTTATTTCTATCTATTTAAGATTGAGTCTGTTTCTCAGCCATTGGAAAACCATGGTGCCCGTATTATTG
GTCATATTTCAGAGTCACTGTCTACCAAATCATGTGGAGCACTCAGACCTGTCAATGGAGTTATTAACACTCTTCAGCCTGTCTTGGCAG
ACCACATTCCAGGTGACAGCTCTGATGCTGAGGAACAATTACATAAGAAGCAACGACTGAATCTCGTCTCTTCATCATCTGATGGCACCT
GTGTGGCAGCCCGGACACGTCCTGTACTGAGCTGTAAGAAGCGGAGGCTTGTTCGACCCAACAGCATCGTTCCTCTTTCCAAGAAGGTTC
ACCGGAACAGCACAATCCGCCCTGGCTGTGATGTGAATCCCTCCTGCGCACTGTGTGGTTCAGGCAGCATCAACACCATGCCTCCCGAAA
TTCACTATGAAGCCCCTCTGTTGGAACGTCTTTCCCAGTTGGACTCTTGTGTTCATCCTGTTCTAGCATTTCCAGATGATGTTCCCACAA
GCCTGCATTTCCAGAGCATGCTGAAATCTCAGTGGCAGAACAAGCCTTTTGACAAAATCAAACCTCCCAAAAAGTTATCGCTTAAGCACA
GAGCACCCATGCCGGGCAGTCTGCCAGATTCAGCTCGTAAGGACAGGCACAAATTGGTCAGCTCCTTCCTAACAACAGCCAAGCTGTCCC
ATCACCAAACCCGGCCTGACAGGACCCACAGGCAGCACTTAGACGATGTGGGGGCCGTGCCCATGGTGGAGCGAGTGACAGCGCCAAAAG
CAGAGCGCTTGCTCAACCCACCACCACCCGTGCATGACCCAAACCACAGCAAAATGAGATTGCGAGACCATTCATCTGAGAGAAGTGAAG
TGTTGAAGCATCACACAGACATGAGCAGTTCGAGCTACTTGGCAGCCACCCACCATCCTCCACACAGTCCCTTGGTGCGACAGCTCTCCA
CCTCCTCAGATTCCCCTGCACCCGCCAGCTCTAGCTCACAGGTTACAGCCAGCACATCGCAGCAGCCAGTAAGGAGGAGAAGGGGAGAGA
GCTCATTTGATATTAACAACATTGTCATCCCAATGTCTGTTGCTGCAACAACTCGCGTAGAGAAACTGCAATACAAGGAAATCCTTACGC
CCAGCTGGCGGGAGGTTGATCTTCAGTCTCTGAAGGGGAGTCCTGATGAGGAGAATGAAGAGATTGAGGACCTATCCGACGCAGCCTTCG
CCGCCCTGCATGCCAAATGTGAGGAGATGGAGAGGGCACGGTGGCTGTGGACCACGAGTGTGCCACCCCAGCGGCGGGGCAGCAGGTCCT
ACAGGTCATCAGACGGCCGGACAACCCCCCAGCTGGGCAGTGCCAACCCCTCCACCCCCCAGCCTGCCTCCCCTGATGTCAGCAGTAGCC
ACTCTTTGTCAGAATACTCCCATGGTCAGTCCCCTAGGAGCCCCATTAGCCCGGAACTGCACTCAGCACCCCTCACCCCTGTGGCTCGGG
ACACTCCGCGACACTTAGCCAGTGAGGATACCCGTTGTTCCACACCAGAGCTGGGGCTGGATGAACAGTCTGTCCAGCCCTGGGAGCGGC
GGACCTTCCCCCTGGCGCACAGTCCCCAGGCGGAGTGTGAGGACCAGCTGGATGCACAGGAGCGAGCAGCCCGCTGCACTCGACGCACCT
CAGGCAGCAAGACTGGCCGGGAGACAGAGGCAGCGCCCACCTCGCCTCCCATTGTCCCCCTCAAGAGTCGGCATCTGGTGGCAGCAGCCA
CAGCTCAGCGCCCGACTCACAGATGAGCGGGAGACAGCCATCTAAACAGACTCACTAACTATTGGCATTAAAGCTTCAGAAATCTCTGCG
TTTGATATTCAAACATCATATGCCGGAAATTTTCACAGTTTTTAGTGAACTTAAGGAATTTAGATCCTACTTTGGTATTTTTTTTTCTTG
TTTTAATTTTTGTTTTGTTTTTGTTTCCATGTTTTCTTGTCACACACCTGAGCACTTCCTCCCGTTGGCAAACAGAAGTTCAGGATGAGA
CCCTGCTGGCCTGGTCCTGGCACATCCTCTGCACTGTTGAATCACTGGACTTACTGATCTTAGATGACCACCCCCTCCCTCACACCTGTG
GGCAGGGCAGAACAGCCTGGCGGGCTACAGTTTAGCATGGCCTTCTTGAGCTAGGGTGGAATGGGGCAGGGTGCTCTGGACTCTTACCCC
CTCCCCTCCCATCTGTGGCTTGGCTCTGCTGTGGCCCTCCTGGCTGGGTCCCCTTGGTTTTTCGTGCTGGAACATCCCCACCAGAGCCTC
TCTGCCATAACTGCCAGCTGCTCTCCCCGAGTGCTCAGCTGGCAGAACACCTTTCCTTTCTCACCCAGAACTTAAGAGACTGATTTTTTG
TTTCATCTGCATTTGGTCTTCTCTGTTTTGACTCTTTCACTGCAGTAACCTGGCTGTGGCTGCTCAGGTTCCCCTCCTCATGCCCCTTGG
TACCCTTCCCTGTCTGCTCTCCCATGCCATGTACACACCCACAACCCGTCCTTCCACTTGGAATATTTTTACCACCTATCCTGATCTTTG
AAGGTAGGGTTAGGACTACTTAACCTCTATTCCCACTCCCCTGCAAACTGGGGGTTGTGGGAAGTGAGCAGCCATCTCCCTGTGTGATTT
TTTTTTTTTTTCCCTCTGATTCACTTTGCCATGTTTCCTTCACATCCAGATCCCTGTCGGTGTTAGTTCCACTCTTGGTCTTTCACGCTC
CCCTTGCCTGTGGAACATTGTCTGGTCCTAGCTGTGGTTCCCATTGTTCCCCCTTCACCCTTCTCTGTTAACCTTGTGCCTGTCTCCTGT
ATGATCACATCACCAAAAAGGGGGAGGGGGGAGAAGACTCTTTTTTTTTGGCCATTTTGTAATCGTATAAAAATAGTAGACAACTGCTTA
ATGGTTGGGGTTTTTTCACAATTTTCAACATTAGTGATTTTTTTTTCTGTTTGCAAGTTAAAGGGTTTGTCATTGTTTCTTTAAAAAAAA
ATACAATAATGCACCATATCCCTATGCATAAAGTGCTTCTTCTATTTATAAGGTTGAAAATTCTGAATAACCCTTTTAGCATTGAAAAAA
AAAACAAAAACAAAAAATGGAAAAAAAAAACCTTGTATTTTGTAAATATTTTCTTTTCCTGCTTTGGAGCTGTGTAATGGCAGCGAAACA
TGTAGCTGTCTTTGTTCTATAGAAATGCTTTTCTTCAGAGAAGCTGATCTTTGTTAATGTCTTGATTCTGTTCGCAAAGCACAGACTAGT
GCTT

>41186_41186_2_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000432791_length(amino acids)=786AA_BP=192
MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKK
LEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKIESVSQPLENHGARIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCV
AARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSL
HFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAKLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAE
RLLNPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDSPAPASSSSQVTASTSQQPVRRRRGESS
FDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYR
SSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHLASEDTRCSTPELGLDEQSVQPWERRT
FPLAHSPQAECEDQLDAQERAARCTRRTSGSKTGRETEAAPTSPPIVPLKSRHLVAAATAQRPTHR

--------------------------------------------------------------
>41186_41186_3_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000572904_length(transcript)=4339nt_BP=1031nt
CCGCGGGCAGCGGAAAAGAGGCCGTGGGGGGCCTCCCAGCGCTGGCAGACACCGTGAGGCTGGCAGCCGCCGGCACGCACACCTAGTCCG
CAGTCCCGAGGAACATGTCCGCAGCCAGGGCGCGGAGCAGAGTCCCGGGCAGGAGAACCAAGGGAGGGCGTGTGCTGTGGCGGCGGCGGC
AGCGGCAGCGGAGCCGCTAGTCCCCTCCCTCCTGGGGGAGCAGCTGCCGCCGCTGCCGCCGCCGCCACCACCATCAGCGCGCGGGGCCCG
GCCAGAGCGAGCCGGGCGAGCGGCGCGCTAGGGGGAGGGCGGGGGCGGGGAGGGGGGTGGGCGAAGGGGGCGGGAGGGCGTGGGGGGAGG
GTCTCGCTCTCCCGACTACCAGAGCCCGAGAGGGAGACCCTGGCGGCGGCGGCGGCGCCTGACACTCGGCGCCTCCTGCCGTGCTCCGGG
GCGGCATGTCCGAGGCTGGCGGGGCCGGGCCGGGCGGCTGCGGGGCAGGAGCCGGGGCAGGGGCCGGGCCCGGGGCGCTGCCCCCGCAGC
CTGCGGCGCTTCCGCCCGCGCCCCCGCAGGGCTCCCCCTGCGCCGCTGCCGCCGGGGGCTCGGGCGCCTGCGGTCCGGCGACGGCAGTGG
CTGCAGCGGGCACGGCCGAAGGACCGGGAGGCGGTGGCTCGGCCCGAATCGCCGTGAAGAAAGCGCAACTACGCTCCGCTCCGCGGGCCA
AGAAACTGGAGAAACTCGGAGTGTACTCCGCCTGCAAGGCCGAGGAGTCTTGTAAATGTAATGGCTGGAAAAACCCTAACCCCTCACCCA
CTCCCCCCAGAGCCGACCTGCAGCAAATAATTGTCAGTCTAACAGAATCCTGTCGGAGTTGTAGCCATGCCCTAGCTGCTCATGTTTCCC
ACCTGGAGAATGTGTCAGAGGAAGAAATGAACAGACTCCTGGGAATAGTATTGGATGTGGAATATCTCTTTACCTGTGTCCACAAGGAAG
AAGATGCAGATACCAAACAAGTTTATTTCTATCTATTTAAGATTGAGTCTGTTTCTCAGCCATTGGAAAACCATGGTGCCCGTATTATTG
GTCATATTTCAGAGTCACTGTCTACCAAATCATGTGGAGCACTCAGACCTGTCAATGGAGTTATTAACACTCTTCAGCCTGTCTTGGCAG
ACCACATTCCAGGTGACAGCTCTGATGCTGAGGAACAATTACATAAGAAGCAACGACTGAATCTCGTCTCTTCATCATCTGATGGCACCT
GTGTGGCAGCCCGGACACGTCCTGTACTGAGCTGTAAGAAGCGGAGGCTTGTTCGACCCAACAGCATCGTTCCTCTTTCCAAGAAGGTTC
ACCGGAACAGCACAATCCGCCCTGGCTGTGATGTGAATCCCTCCTGCGCACTGTGTGGTTCAGGCAGCATCAACACCATGCCTCCCGAAA
TTCACTATGAAGCCCCTCTGTTGGAACGTCTTTCCCAGTTGGACTCTTGTGTTCATCCTGTTCTAGCATTTCCAGATGATGTTCCCACAA
GCCTGCATTTCCAGAGCATGCTGAAATCTCAGTGGCAGAACAAGCCTTTTGACAAAATCAAACCTCCCAAAAAGTTATCGCTTAAGCACA
GAGCACCCATGCCGGGCAGTCTGCCAGATTCAGCTCGTAAGGACAGGCACAAATTGGTCAGCTCCTTCCTAACAACAGCCAAGCTGTCCC
ATCACCAAACCCGGCCTGACAGGACCCACAGGCAGCACTTAGACGATGTGGGGGCCGTGCCCATGGTGGAGCGAGTGACAGCGCCAAAAG
CAGAGCGCTTGCTCAACCCACCACCACCCGTGCATGACCCAAACCACAGCAAAATGAGATTGCGAGACCATTCATCTGAGAGAAGTGAAG
TGTTGAAGCATCACACAGACATGAGCAGTTCGAGCTACTTGGCAGCCACCCACCATCCTCCACACAGTCCCTTGGTGCGACAGCTCTCCA
CCTCCTCAGATTCCCCTGCACCCGCCAGCTCTAGCTCACAGGTTACAGCCAGCACATCGCAGCAGCCAGTAAGGAGGAGAAGGGGAGAGA
GCTCATTTGATATTAACAACATTGTCATCCCAATGTCTGTTGCTGCAACAACTCGCGTAGAGAAACTGCAATACAAGGAAATCCTTACGC
CCAGCTGGCGGGAGGTTGATCTTCAGTCTCTGAAGGGGAGTCCTGATGAGGAGAATGAAGAGATTGAGGACCTATCCGACGCAGCCTTCG
CCGCCCTGCATGCCAAATGTGAGGAGATGGAGAGGGCACGGTGGCTGTGGACCACGAGTGTGCCACCCCAGCGGCGGGGCAGCAGGTCCT
ACAGGTCATCAGACGGCCGGACAACCCCCCAGCTGGGCAGTGCCAACCCCTCCACCCCCCAGCCTGCCTCCCCTGATGTCAGCAGTAGCC
ACTCTTTGTCAGAATACTCCCATGGTCAGTCCCCTAGGAGCCCCATTAGCCCGGAACTGCACTCAGCACCCCTCACCCCTGTGGCTCGGG
ACACTCCGCGACACTTAGCCAGTGAGGATACCCGTTGTTCCACACCAGAGCTGGGGCTGGATGAACAGTCTGTCCAGCCCTGGGAGCGGC
GGACCTTCCCCCTGGCGCACAGTCCCCAGGCGGAGTGTGAGGACCAGCTGGATGCACAGGAGCGAGCAGCCCGCTGCACTCGACGCACCT
CAGGCAGCAAGACTGGCCGGGAGACAGAGGCAGCGCCCACCTCGCCTCCCATTGTCCCCCTCAAGAGTCGGCATCTGGTGGCAGCAGCCA
CAGCTCAGCGCCCGACTCACAGATGAGCGGGAGACAGCCATCTAAACAGACTCACTAACTATTGGCATTAAAGCTTCAGAAATCTCTGCG
TTTGATATTCAAACATCATATGCCGGAAATTTTCACAGTTTTTAGTGAACTTAAGGAATTTAGATCCTACTTTGGTATTTTTTTTTCTTG
TTTTAATTTTTGTTTTGTTTTTGTTTCCATGTTTTCTTGTCACACACCTGAGCACTTCCTCCCGTTGGCAAACAGAAGTTCAGGATGAGA
CCCTGCTGGCCTGGTCCTGGCACATCCTCTGCACTGTTGAATCACTGGACTTACTGATCTTAGATGACCACCCCCTCCCTCACACCTGTG
GGCAGGGCAGAACAGCCTGGCGGGCTACAGTTTAGCATGGCCTTCTTGAGCTAGGGTGGAATGGGGCAGGGTGCTCTGGACTCTTACCCC
CTCCCCTCCCATCTGTGGCTTGGCTCTGCTGTGGCCCTCCTGGCTGGGTCCCCTTGGTTTTTCGTGCTGGAACATCCCCACCAGAGCCTC
TCTGCCATAACTGCCAGCTGCTCTCCCCGAGTGCTCAGCTGGCAGAACACCTTTCCTTTCTCACCCAGAACTTAAGAGACTGATTTTTTG
TTTCATCTGCATTTGGTCTTCTCTGTTTTGACTCTTTCACTGCAGTAACCTGGCTGTGGCTGCTCAGGTTCCCCTCCTCATGCCCCTTGG
TACCCTTCCCTGTCTGCTCTCCCATGCCATGTACACACCCACAACCCGTCCTTCCACTTGGAATATTTTTACCACCTATCCTGATCTTTG
AAGGTAGGGTTAGGACTACTTAACCTCTATTCCCACTCCCCTGCAAACTGGGGGTTGTGGGAAGTGAGCAGCCATCTCCCTGTGTGATTT
TTTTTTTTTTTCCCTCTGATTCACTTTGCCATGTTTCCTTCACATCCAGATCCCTGTCGGTGTTAGTTCCACTCTTGGTCTTTCACGCTC
CCCTTGCCTGTGGAACATTGTCTGGTCCTAGCTGTGGTTCCCATTGTTCCCCCTTCACCCTTCTCTGTTAACCTTGTGCCTGTCTCCTGT
ATGATCACATCACCAAAAAGGGGGAGGGGGGAGAAGACTCTTTTTTTTTGGCCATTTTGTAATCGTATAAAAATAGTAGACAACTGCTTA
ATGGTTGGGGTTTTTTCACAATTTTCAACATTAGTGATTTTTTTTTCTGTTTGCAAGTTAAAGGGTTTGTCATTGTTTCTTTAAAAAAAA
ATACAATAATGCACCATATCCCTATGCATAAAGTGCTTCTTCTATTTATAAGGTTGAAAATTCTGAATAACCCTTTTAGCATTGAAAAAA
AAAACAAAAACAAAAAATGGAAAAAAAAAACCTTGTATTTTGTAAATATTTTCTTTTCCTGCTTTGGAGCTGTGTAATGGCAGCGAAACA
TGTAGCTGTCTTTGTTCTATAGAAATGCTTTTCTTCAGAGAAGCTGATCTTTGTTAATGTCTTGATTCTGTTCGCAAAGCACAGACTAGT
GCTTAAAAAAAAAAAAGAA

>41186_41186_3_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000572904_length(amino acids)=786AA_BP=192
MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKK
LEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKIESVSQPLENHGARIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCV
AARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSL
HFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAKLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAE
RLLNPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDSPAPASSSSQVTASTSQQPVRRRRGESS
FDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYR
SSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHLASEDTRCSTPELGLDEQSVQPWERRT
FPLAHSPQAECEDQLDAQERAARCTRRTSGSKTGRETEAAPTSPPIVPLKSRHLVAAATAQRPTHR

--------------------------------------------------------------
>41186_41186_4_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000574590_length(transcript)=4376nt_BP=1031nt
CCGCGGGCAGCGGAAAAGAGGCCGTGGGGGGCCTCCCAGCGCTGGCAGACACCGTGAGGCTGGCAGCCGCCGGCACGCACACCTAGTCCG
CAGTCCCGAGGAACATGTCCGCAGCCAGGGCGCGGAGCAGAGTCCCGGGCAGGAGAACCAAGGGAGGGCGTGTGCTGTGGCGGCGGCGGC
AGCGGCAGCGGAGCCGCTAGTCCCCTCCCTCCTGGGGGAGCAGCTGCCGCCGCTGCCGCCGCCGCCACCACCATCAGCGCGCGGGGCCCG
GCCAGAGCGAGCCGGGCGAGCGGCGCGCTAGGGGGAGGGCGGGGGCGGGGAGGGGGGTGGGCGAAGGGGGCGGGAGGGCGTGGGGGGAGG
GTCTCGCTCTCCCGACTACCAGAGCCCGAGAGGGAGACCCTGGCGGCGGCGGCGGCGCCTGACACTCGGCGCCTCCTGCCGTGCTCCGGG
GCGGCATGTCCGAGGCTGGCGGGGCCGGGCCGGGCGGCTGCGGGGCAGGAGCCGGGGCAGGGGCCGGGCCCGGGGCGCTGCCCCCGCAGC
CTGCGGCGCTTCCGCCCGCGCCCCCGCAGGGCTCCCCCTGCGCCGCTGCCGCCGGGGGCTCGGGCGCCTGCGGTCCGGCGACGGCAGTGG
CTGCAGCGGGCACGGCCGAAGGACCGGGAGGCGGTGGCTCGGCCCGAATCGCCGTGAAGAAAGCGCAACTACGCTCCGCTCCGCGGGCCA
AGAAACTGGAGAAACTCGGAGTGTACTCCGCCTGCAAGGCCGAGGAGTCTTGTAAATGTAATGGCTGGAAAAACCCTAACCCCTCACCCA
CTCCCCCCAGAGCCGACCTGCAGCAAATAATTGTCAGTCTAACAGAATCCTGTCGGAGTTGTAGCCATGCCCTAGCTGCTCATGTTTCCC
ACCTGGAGAATGTGTCAGAGGAAGAAATGAACAGACTCCTGGGAATAGTATTGGATGTGGAATATCTCTTTACCTGTGTCCACAAGGAAG
AAGATGCAGATACCAAACAAGTTTATTTCTATCTATTTAAGATTGAGTCTGTTTCTCAGCCATTGGAAAACCATGGTGCCCGTATTATTG
GTCATATTTCAGAGTCACTGTCTACCAAATCATGTGGAGCACTCAGACCTGTCAATGGAGTTATTAACACTCTTCAGCCTGTCTTGGCAG
ACCACATTCCAGGTGACAGCTCTGATGCTGAGGAACAATTACATAAGAAGCAACGACTGAATCTCGTCTCTTCATCATCTGATGGCACCT
GTGTGGCAGCCCGGACACGTCCTGTACTGAGCTGTAAGAAGCGGAGGCTTGTTCGACCCAACAGCATCGTTCCTCTTTCCAAGAAGGTTC
ACCGGAACAGCACAATCCGCCCTGGCTGTGATGTGAATCCCTCCTGCGCACTGTGTGGTTCAGGCAGCATCAACACCATGCCTCCCGAAA
TTCACTATGAAGCCCCTCTGTTGGAACGTCTTTCCCAGTTGGACTCTTGTGTTCATCCTGTTCTAGCATTTCCAGATGATGTTCCCACAA
GCCTGCATTTCCAGAGCATGCTGAAATCTCAGTGGCAGAACAAGCCTTTTGACAAAATCAAACCTCCCAAAAAGTTATCGCTTAAGCACA
GAGCACCCATGCCGGGCAGTCTGCCAGATTCAGCTCGTAAGGACAGGCACAAATTGGTCAGCTCCTTCCTAACAACAGCCAAGCTGTCCC
ATCACCAAACCCGGCCTGACAGGACCCACAGGCAGCACTTAGACGATGTGGGGGCCGTGCCCATGGTGGAGCGAGTGACAGCGCCAAAAG
CAGAGCGCTTGCTCAACCCACCACCACCCGTGCATGACCCAAACCACAGCAAAATGAGATTGCGAGACCATTCATCTGAGAGAAGTGAAG
TGTTGAAGCATCACACAGACATGAGCAGTTCGAGCTACTTGGCAGCCACCCACCATCCTCCACACAGTCCCTTGGTGCGACAGCTCTCCA
CCTCCTCAGATTCCCCTGCACCCGCCAGCTCTAGCTCACAGGTTACAGCCAGCACATCGCAGCAGCCAGTAAGGAGGAGAAGGGGAGAGA
GCTCATTTGATATTAACAACATTGTCATCCCAATGTCTGTTGCTGCAACAACTCGCGTAGAGAAACTGCAATACAAGGAAATCCTTACGC
CCAGCTGGCGGGAGGTTGATCTTCAGTCTCTGAAGGGGAGTCCTGATGAGGAGAATGAAGAGATTGAGGACCTATCCGACGCAGCCTTCG
CCGCCCTGCATGCCAAATGTGAGGAGATGGAGAGGGCACGGTGGCTGTGGACCACGAGTGTGCCACCCCAGCGGCGGGGCAGCAGGTCCT
ACAGGTCATCAGACGGCCGGACAACCCCCCAGCTGGGCAGTGCCAACCCCTCCACCCCCCAGCCTGCCTCCCCTGATGTCAGCAGTAGCC
ACTCTTTGTCAGAATACTCCCATGGTCAGTCCCCTAGGAGCCCCATTAGCCCGGAACTGCACTCAGCACCCCTCACCCCTGTGGCTCGGG
ACACTCCGCGACACTTAGCCAGTGAGGATACCCGTTGTTCCACACCAGAGCTGGGGCTGGATGAACAGTCTGTCCAGCCCTGGGAGCGGC
GGACCTTCCCCCTGGCGCACAGTCCCCAGGCGGAGTGTGAGGACCAGCTGGATGCACAGGAGCGAGCAGCCCGCTGCACTCGACGCACCT
CAGGCAGCAAGACTGGCCGGGAGACAGAGGCAGCGCCCACCTCGCCTCCCATTGTCCCCCTCAAGAGTCGGCATCTGGTGGCAGCAGCCA
CAGCTCAGCGCCCGACTCACAGATGAGCGGGAGACAGCCATCTAAACAGACTCACTAACTATTGGCATTAAAGCTTCAGAAATCTCTGCG
TTTGATATTCAAACATCATATGCCGGAAATTTTCACAGTTTTTAGTGAACTTAAGGAATTTAGATCCTACTTTGGTATTTTTTTTTCTTG
TTTTAATTTTTGTTTTGTTTTTGTTTCCATGTTTTCTTGTCACACACCTGAGCACTTCCTCCCGTTGGCAAACAGAAGTTCAGGATGAGA
CCCTGCTGGCCTGGTCCTGGCACATCCTCTGCACTGTTGAATCACTGGACTTACTGATCTTAGATGACCACCCCCTCCCTCACACCTGTG
GGCAGGGCAGAACAGCCTGGCGGGCTACAGTTTAGCATGGCCTTCTTGAGCTAGGGTGGAATGGGGCAGGGTGCTCTGGACTCTTACCCC
CTCCCCTCCCATCTGTGGCTTGGCTCTGCTGTGGCCCTCCTGGCTGGGTCCCCTTGGTTTTTCGTGCTGGAACATCCCCACCAGAGCCTC
TCTGCCATAACTGCCAGCTGCTCTCCCCGAGTGCTCAGCTGGCAGAACACCTTTCCTTTCTCACCCAGAACTTAAGAGACTGATTTTTTG
TTTCATCTGCATTTGGTCTTCTCTGTTTTGACTCTTTCACTGCAGTAACCTGGCTGTGGCTGCTCAGGTTCCCCTCCTCATGCCCCTTGG
TACCCTTCCCTGTCTGCTCTCCCATGCCATGTACACACCCACAACCCGTCCTTCCACTTGGAATATTTTTACCACCTATCCTGATCTTTG
AAGGTAGGGTTAGGACTACTTAACCTCTATTCCCACTCCCCTGCAAACTGGGGGTTGTGGGAAGTGAGCAGCCATCTCCCTGTGTGATTT
TTTTTTTTTTTCCCTCTGATTCACTTTGCCATGTTTCCTTCACATCCAGATCCCTGTCGGTGTTAGTTCCACTCTTGGTCTTTCACGCTC
CCCTTGCCTGTGGAACATTGTCTGGTCCTAGCTGTGGTTCCCATTGTTCCCCCTTCACCCTTCTCTGTTAACCTTGTGCCTGTCTCCTGT
ATGATCACATCACCAAAAAGGGGGAGGGGGGAGAAGACTCTTTTTTTTTGGCCATTTTGTAATCGTATAAAAATAGTAGACAACTGCTTA
ATGGTTGGGGTTTTTTCACAATTTTCAACATTAGTGATTTTTTTTTCTGTTTGCAAGTTAAAGGGTTTGTCATTGTTTCTTTAAAAAAAA
ATACAATAATGCACCATATCCCTATGCATAAAGTGCTTCTTCTATTTATAAGGTTGAAAATTCTGAATAACCCTTTTAGCATTGAAAAAA
AAAACAAAAACAAAAAATGGAAAAAAAAAACCTTGTATTTTGTAAATATTTTCTTTTCCTGCTTTGGAGCTGTGTAATGGCAGCGAAACA
TGTAGCTGTCTTTGTTCTATAGAAATGCTTTTCTTCAGAGAAGCTGATCTTTGTTAATGTCTTGATTCTGTTCGCAAAGCACAGACTAGT
GCTTAAAAAAAAAAAAGAAGGAAAAATTGAAAAAAATAAAAAAAAAAGTTACAGAA

>41186_41186_4_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000574590_length(amino acids)=786AA_BP=192
MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKK
LEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKIESVSQPLENHGARIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCV
AARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSL
HFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAKLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAE
RLLNPPPPVHDPNHSKMRLRDHSSERSEVLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDSPAPASSSSQVTASTSQQPVRRRRGESS
FDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYR
SSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHLASEDTRCSTPELGLDEQSVQPWERRT
FPLAHSPQAECEDQLDAQERAARCTRRTSGSKTGRETEAAPTSPPIVPLKSRHLVAAATAQRPTHR

--------------------------------------------------------------
>41186_41186_5_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000575318_length(transcript)=4175nt_BP=1031nt
CCGCGGGCAGCGGAAAAGAGGCCGTGGGGGGCCTCCCAGCGCTGGCAGACACCGTGAGGCTGGCAGCCGCCGGCACGCACACCTAGTCCG
CAGTCCCGAGGAACATGTCCGCAGCCAGGGCGCGGAGCAGAGTCCCGGGCAGGAGAACCAAGGGAGGGCGTGTGCTGTGGCGGCGGCGGC
AGCGGCAGCGGAGCCGCTAGTCCCCTCCCTCCTGGGGGAGCAGCTGCCGCCGCTGCCGCCGCCGCCACCACCATCAGCGCGCGGGGCCCG
GCCAGAGCGAGCCGGGCGAGCGGCGCGCTAGGGGGAGGGCGGGGGCGGGGAGGGGGGTGGGCGAAGGGGGCGGGAGGGCGTGGGGGGAGG
GTCTCGCTCTCCCGACTACCAGAGCCCGAGAGGGAGACCCTGGCGGCGGCGGCGGCGCCTGACACTCGGCGCCTCCTGCCGTGCTCCGGG
GCGGCATGTCCGAGGCTGGCGGGGCCGGGCCGGGCGGCTGCGGGGCAGGAGCCGGGGCAGGGGCCGGGCCCGGGGCGCTGCCCCCGCAGC
CTGCGGCGCTTCCGCCCGCGCCCCCGCAGGGCTCCCCCTGCGCCGCTGCCGCCGGGGGCTCGGGCGCCTGCGGTCCGGCGACGGCAGTGG
CTGCAGCGGGCACGGCCGAAGGACCGGGAGGCGGTGGCTCGGCCCGAATCGCCGTGAAGAAAGCGCAACTACGCTCCGCTCCGCGGGCCA
AGAAACTGGAGAAACTCGGAGTGTACTCCGCCTGCAAGGCCGAGGAGTCTTGTAAATGTAATGGCTGGAAAAACCCTAACCCCTCACCCA
CTCCCCCCAGAGCCGACCTGCAGCAAATAATTGTCAGTCTAACAGAATCCTGTCGGAGTTGTAGCCATGCCCTAGCTGCTCATGTTTCCC
ACCTGGAGAATGTGTCAGAGGAAGAAATGAACAGACTCCTGGGAATAGTATTGGATGTGGAATATCTCTTTACCTGTGTCCACAAGGAAG
AAGATGCAGATACCAAACAAGTTTATTTCTATCTATTTAAGATTGAGTCTGTTTCTCAGCCATTGGAAAACCATGGTGCCCGTATTATTG
GTCATATTTCAGAGTCACTGTCTACCAAATCATGTGGAGCACTCAGACCTGTCAATGGAGTTATTAACACTCTTCAGCCTGTCTTGGCAG
ACCACATTCCAGGTGACAGCTCTGATGCTGAGGAACAATTACATAAGAAGCAACGACTGAATCTCGTCTCTTCATCATCTGATGGCACCT
GTGTGGCAGCCCGGACACGTCCTGTACTGAGCTGTAAGAAGCGGAGGCTTGTTCGACCCAACAGCATCGTTCCTCTTTCCAAGAAGGTTC
ACCGGAACAGCACAATCCGCCCTGGCTGTGATGTGAATCCCTCCTGCGCACTGTGTGGTTCAGGCAGCATCAACACCATGCCTCCCGAAA
TTCACTATGAAGCCCCTCTGTTGGAACGTCTTTCCCAGTTGGACTCTTGTGTTCATCCTGTTCTAGCATTTCCAGATGATGTTCCCACAA
GCCTGCATTTCCAGAGCATGCTGAAATCTCAGTGGCAGAACAAGCCTTTTGACAAAATCAAACCTCCCAAAAAGTTATCGCTTAAGCACA
GAGCACCCATGCCGGGCAGTCTGCCAGATTCAGCTCGTAAGGACAGGCACAAATTGGTCAGCTCCTTCCTAACAACAGCCATGTTGAAGC
ATCACACAGACATGAGCAGTTCGAGCTACTTGGCAGCCACCCACCATCCTCCACACAGTCCCTTGGTGCGACAGCTCTCCACCTCCTCAG
ATTCCCCTGCACCCGCCAGCTCTAGCTCACAGGTTACAGCCAGCACATCGCAGCCAGTAAGGAGGAGAAGGGGAGAGAGCTCATTTGATA
TTAACAACATTGTCATCCCAATGTCTGTTGCTGCAACAACTCGCGTAGAGAAACTGCAATACAAGGAAATCCTTACGCCCAGCTGGCGGG
AGGTTGATCTTCAGTCTCTGAAGGGGAGTCCTGATGAGGAGAATGAAGAGATTGAGGACCTATCCGACGCAGCCTTCGCCGCCCTGCATG
CCAAATGTGAGGAGATGGAGAGGGCACGGTGGCTGTGGACCACGAGTGTGCCACCCCAGCGGCGGGGCAGCAGGTCCTACAGGTCATCAG
ACGGCCGGACAACCCCCCAGCTGGGCAGTGCCAACCCCTCCACCCCCCAGCCTGCCTCCCCTGATGTCAGCAGTAGCCACTCTTTGTCAG
AATACTCCCATGGTCAGTCCCCTAGGAGCCCCATTAGCCCGGAACTGCACTCAGCACCCCTCACCCCTGTGGCTCGGGACACTCCGCGAC
ACTTAGCCAGTGAGGATACCCGTTGTTCCACACCAGAGCTGGGGCTGGATGAACAGTCTGTCCAGCCCTGGGAGCGGCGGACCTTCCCCC
TGGCGCACAGTCCCCAGGCGGAGTGTGAGGACCAGCTGGATGCACAGGAGCGAGCAGCCCGCTGCACTCGACGCACCTCAGGCAGCAAGA
CTGGCCGGGAGACAGAGGCAGCGCCCACCTCGCCTCCCATTGTCCCCCTCAAGAGTCGGCATCTGGTGGCAGCAGCCACAGCTCAGCGCC
CGACTCACAGATGAGCGGGAGACAGCCATCTAAACAGACTCACTAACTATTGGCATTAAAGCTTCAGAAATCTCTGCGTTTGATATTCAA
ACATCATATGCCGGAAATTTTCACAGTTTTTAGTGAACTTAAGGAATTTAGATCCTACTTTGGTATTTTTTTTTCTTGTTTTAATTTTTG
TTTTGTTTTTGTTTCCATGTTTTCTTGTCACACACCTGAGCACTTCCTCCCGTTGGCAAACAGAAGTTCAGGATGAGACCCTGCTGGCCT
GGTCCTGGCACATCCTCTGCACTGTTGAATCACTGGACTTACTGATCTTAGATGACCACCCCCTCCCTCACACCTGTGGGCAGGGCAGAA
CAGCCTGGCGGGCTACAGTTTAGCATGGCCTTCTTGAGCTAGGGTGGAATGGGGCAGGGTGCTCTGGACTCTTACCCCCTCCCCTCCCAT
CTGTGGCTTGGCTCTGCTGTGGCCCTCCTGGCTGGGTCCCCTTGGTTTTTCGTGCTGGAACATCCCCACCAGAGCCTCTCTGCCATAACT
GCCAGCTGCTCTCCCCGAGTGCTCAGCTGGCAGAACACCTTTCCTTTCTCACCCAGAACTTAAGAGACTGATTTTTTGTTTCATCTGCAT
TTGGTCTTCTCTGTTTTGACTCTTTCACTGCAGTAACCTGGCTGTGGCTGCTCAGGTTCCCCTCCTCATGCCCCTTGGTACCCTTCCCTG
TCTGCTCTCCCATGCCATGTACACACCCACAACCCGTCCTTCCACTTGGAATATTTTTACCACCTATCCTGATCTTTGAAGGTAGGGTTA
GGACTACTTAACCTCTATTCCCACTCCCCTGCAAACTGGGGGTTGTGGGAAGTGAGCAGCCATCTCCCTGTGTGATTTTTTTTTTTTTTC
CCTCTGATTCACTTTGCCATGTTTCCTTCACATCCAGATCCCTGTCGGTGTTAGTTCCACTCTTGGTCTTTCACGCTCCCCTTGCCTGTG
GAACATTGTCTGGTCCTAGCTGTGGTTCCCATTGTTCCCCCTTCACCCTTCTCTGTTAACCTTGTGCCTGTCTCCTGTATGATCACATCA
CCAAAAAGGGGGAGGGGGGAGAAGACTCTTTTTTTTTGGCCATTTTGTAATCGTATAAAAATAGTAGACAACTGCTTAATGGTTGGGGTT
TTTTCACAATTTTCAACATTAGTGATTTTTTTTTCTGTTTGCAAGTTAAAGGGTTTGTCATTGTTTCTTTAAAAAAAAATACAATAATGC
ACCATATCCCTATGCATAAAGTGCTTCTTCTATTTATAAGGTTGAAAATTCTGAATAACCCTTTTAGCATTGAAAAAAAAAACAAAAACA
AAAAATGGAAAAAAAAAACCTTGTATTTTGTAAATATTTTCTTTTCCTGCTTTGGAGCTGTGTAATGGCAGCGAAACATGTAGCTGTCTT
TGTTCTATAGAAATGCTTTTCTTCAGAGAAGCTGATCTTTGTTAATGTCTTGATTCTGTTCGCAAAGCACAGACTAGTGCTTAAAAAAAA
AAAAGAAGGAAAAATTGAAAAAAATAAAAAAAAAA

>41186_41186_5_KAT2B-KANSL1_KAT2B_chr3_20136900_ENST00000263754_KANSL1_chr17_44145033_ENST00000575318_length(amino acids)=722AA_BP=192
MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKK
LEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKIESVSQPLENHGARIIGHISESLSTKSCGALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCV
AARTRPVLSCKKRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSL
HFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSARKDRHKLVSSFLTTAMLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDS
PAPASSSSQVTASTSQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKGSPDEENEEIEDLSDAAFAALHAK
CEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHL
ASEDTRCSTPELGLDEQSVQPWERRTFPLAHSPQAECEDQLDAQERAARCTRRTSGSKTGRETEAAPTSPPIVPLKSRHLVAAATAQRPT
HR

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Fusion Gene PPI Analysis for KAT2B-KANSL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KAT2B-KANSL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KAT2B-KANSL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKAT2BC0525045Mood Disorders1PSYGENET
TgeneC0020796Profound Mental Retardation2CTD_human
TgeneC0025363Mental Retardation, Psychosocial2CTD_human
TgeneC0026825Flaccid Muscle Tone2CTD_human
TgeneC0026827Muscle hypotonia2CTD_human
TgeneC0376634Craniofacial Abnormalities2CTD_human
TgeneC0427201Floppy Muscles2CTD_human
TgeneC0427202Muscle Tone Atonic2CTD_human
TgeneC0751330Unilateral Hypotonia2CTD_human
TgeneC0917816Mental deficiency2CTD_human
TgeneC1864871Chromosome 17q21.31 Deletion Syndrome2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC2267233Neonatal Hypotonia2CTD_human
TgeneC2931713Chromosome 17 deletion2CTD_human
TgeneC3683846Chromosome 17p Deletion Syndrome2CTD_human
TgeneC3714756Intellectual Disability2CTD_human
TgeneC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneC0919267ovarian neoplasm1CTD_human
TgeneC1140680Malignant neoplasm of ovary1CTD_human
TgeneC1860789Leukemia, Megakaryoblastic, of Down Syndrome1CTD_human