Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARHGEF7-ING1 (FusionGDB2 ID:HG8874TG3621)

Fusion Gene Summary for ARHGEF7-ING1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF7-ING1
Fusion gene ID: hg8874tg3621
HgeneTgene
Gene symbol

ARHGEF7

ING1

Gene ID

8874

3621

Gene nameRho guanine nucleotide exchange factor 7inhibitor of growth family member 1
SynonymsBETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXBp24ING1c|p33|p33ING1|p33ING1b|p47|p47ING1a
Cytomap('ARHGEF7')('ING1')

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich proteininhibitor of growth protein 1growth inhibitor ING1growth inhibitory protein ING1tumor suppressor ING1
Modification date2020032720200313
UniProtAcc.

Q9UK53

Ensembl transtripts involved in fusion geneENST00000317133, ENST00000370623, 
ENST00000375741, ENST00000218789, 
ENST00000375736, ENST00000544132, 
ENST00000375723, ENST00000375737, 
ENST00000375739, ENST00000426073, 
ENST00000478679, ENST00000483189, 
Fusion gene scores* DoF score25 X 17 X 12=51007 X 5 X 4=140
# samples 267
** MAII scorelog2(26/5100*10)=-4.29391371871777
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF7 [Title/Abstract] AND ING1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF7(111806338)-ING1(111371576), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGEF7-ING1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF7-ING1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF7-ING1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF7-ING1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF7-ING1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARHGEF7-ING1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ARHGEF7-ING1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF7

GO:0043547

positive regulation of GTPase activity

21048939


check buttonFusion gene breakpoints across ARHGEF7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ING1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-A01K-01AARHGEF7chr13

111806338

+ING1chr13

111371576

+


Top

Fusion Gene ORF analysis for ARHGEF7-ING1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000317133ENST00000464141ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5CDS-3UTRENST00000370623ENST00000464141ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5CDS-3UTRENST00000375741ENST00000464141ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5CDS-5UTRENST00000317133ENST00000375774ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5CDS-5UTRENST00000317133ENST00000375775ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5CDS-5UTRENST00000370623ENST00000375774ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5CDS-5UTRENST00000370623ENST00000375775ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5CDS-5UTRENST00000375741ENST00000375774ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5CDS-5UTRENST00000375741ENST00000375775ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-3CDSENST00000218789ENST00000333219ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-3CDSENST00000218789ENST00000338450ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-3CDSENST00000375736ENST00000333219ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-3CDSENST00000375736ENST00000338450ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-3CDSENST00000544132ENST00000333219ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-3CDSENST00000544132ENST00000338450ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-3UTRENST00000218789ENST00000464141ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-3UTRENST00000375736ENST00000464141ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-3UTRENST00000544132ENST00000464141ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-5UTRENST00000218789ENST00000375774ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-5UTRENST00000218789ENST00000375775ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-5UTRENST00000375736ENST00000375774ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-5UTRENST00000375736ENST00000375775ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-5UTRENST00000544132ENST00000375774ARHGEF7chr13

111806338

+ING1chr13

111371576

+
5UTR-5UTRENST00000544132ENST00000375775ARHGEF7chr13

111806338

+ING1chr13

111371576

+
Frame-shiftENST00000317133ENST00000333219ARHGEF7chr13

111806338

+ING1chr13

111371576

+
Frame-shiftENST00000370623ENST00000333219ARHGEF7chr13

111806338

+ING1chr13

111371576

+
Frame-shiftENST00000375741ENST00000333219ARHGEF7chr13

111806338

+ING1chr13

111371576

+
In-frameENST00000317133ENST00000338450ARHGEF7chr13

111806338

+ING1chr13

111371576

+
In-frameENST00000370623ENST00000338450ARHGEF7chr13

111806338

+ING1chr13

111371576

+
In-frameENST00000375741ENST00000338450ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3CDSENST00000375723ENST00000333219ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3CDSENST00000375723ENST00000338450ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3CDSENST00000375737ENST00000333219ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3CDSENST00000375737ENST00000338450ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3CDSENST00000375739ENST00000333219ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3CDSENST00000375739ENST00000338450ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3CDSENST00000426073ENST00000333219ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3CDSENST00000426073ENST00000338450ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3CDSENST00000478679ENST00000333219ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3CDSENST00000478679ENST00000338450ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3CDSENST00000483189ENST00000333219ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3CDSENST00000483189ENST00000338450ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3UTRENST00000375723ENST00000464141ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3UTRENST00000375737ENST00000464141ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3UTRENST00000375739ENST00000464141ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3UTRENST00000426073ENST00000464141ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3UTRENST00000478679ENST00000464141ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-3UTRENST00000483189ENST00000464141ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-5UTRENST00000375723ENST00000375774ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-5UTRENST00000375723ENST00000375775ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-5UTRENST00000375737ENST00000375774ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-5UTRENST00000375737ENST00000375775ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-5UTRENST00000375739ENST00000375774ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-5UTRENST00000375739ENST00000375775ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-5UTRENST00000426073ENST00000375774ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-5UTRENST00000426073ENST00000375775ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-5UTRENST00000478679ENST00000375774ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-5UTRENST00000478679ENST00000375775ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-5UTRENST00000483189ENST00000375774ARHGEF7chr13

111806338

+ING1chr13

111371576

+
intron-5UTRENST00000483189ENST00000375775ARHGEF7chr13

111806338

+ING1chr13

111371576

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000317133ARHGEF7chr13111806338+ENST00000338450ING1chr13111371576+2107116010301863277
ENST00000375741ARHGEF7chr13111806338+ENST00000338450ING1chr13111371576+14495023721205277
ENST00000370623ARHGEF7chr13111806338+ENST00000338450ING1chr13111371576+1199252122955277

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317133ENST00000338450ARHGEF7chr13111806338+ING1chr13111371576+0.0110984340.9889016
ENST00000375741ENST00000338450ARHGEF7chr13111806338+ING1chr13111371576+0.0117363860.9882636
ENST00000370623ENST00000338450ARHGEF7chr13111806338+ING1chr13111371576+0.0240032780.97599673

Top

Fusion Genomic Features for ARHGEF7-ING1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGEF7chr13111806338+ING1chr13111371575+3.63E-101
ARHGEF7chr13111806338+ING1chr13111371575+3.63E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ARHGEF7-ING1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:111806338/chr13:111371576)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ING1

Q9UK53

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:9440695}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneING1chr13:111806338chr13:111371576ENST0000033321902405_42245280.0RegionPBR
TgeneING1chr13:111806338chr13:111371576ENST0000033845002405_4221236.0RegionPBR
TgeneING1chr13:111806338chr13:111371576ENST0000037577402405_422188423.0RegionPBR
TgeneING1chr13:111806338chr13:111371576ENST0000037577502405_4220211.0RegionPBR
TgeneING1chr13:111806338chr13:111371576ENST0000033321902353_40245280.0Zinc fingerPHD-type
TgeneING1chr13:111806338chr13:111371576ENST0000033845002353_4021236.0Zinc fingerPHD-type
TgeneING1chr13:111806338chr13:111371576ENST0000037577402353_402188423.0Zinc fingerPHD-type
TgeneING1chr13:111806338chr13:111371576ENST0000037577502353_4020211.0Zinc fingerPHD-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000317133+219184_24384783.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000317133+2191_13384783.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000317133+219271_45184783.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000317133+219473_57884783.0DomainPH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000370623+219184_24384732.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000370623+2191_13384732.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000370623+219271_45184732.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000370623+219473_57884732.0DomainPH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375723+117184_2430626.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375723+1171_1330626.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375723+117271_4510626.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375723+117473_5780626.0DomainPH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375736+120184_2430647.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375736+1201_1330647.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375736+120271_4510647.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375736+120473_5780647.0DomainPH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375739+118184_2430754.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375739+1181_1330754.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375739+118271_4510754.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375739+118473_5780754.0DomainPH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375741+220184_24384804.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375741+2201_13384804.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375741+220271_45184804.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375741+220473_57884804.0DomainPH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000426073+120184_2430647.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000426073+1201_1330647.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000426073+120271_4510647.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000426073+120473_5780647.0DomainPH


Top

Fusion Gene Sequence for ARHGEF7-ING1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6347_6347_1_ARHGEF7-ING1_ARHGEF7_chr13_111806338_ENST00000317133_ING1_chr13_111371576_ENST00000338450_length(transcript)=2107nt_BP=1160nt
CCCCGAGACGCAGCCAGGCGCCCGGCCCGGCCCGGCCCGGCCCTCTGCACAGCCCCACTTCAGGCCACGCCGTTTCCTTGACCTTCCCCC
GGCAGGGTCTGAAGCGTCACCGTCCGTCTAGAGCAGAGTCGCGCAGGCCCCTGCCCTGCCGGTGAGGTCGGCGCCGCGCTCCGGAGAGTC
GGTTCCTCCCGATTCAGACCCATATGGCTTCAGATGGAACCATCATTTCTGTTCCGTCATGACCGGCTTGCAAGGTAGCAAAGCGAAACA
AACGTCTCGTTTTCAGCCTGTCCCCGCCACCTTGAAATAAAACCGGCAAAAATAAAAAGAGCATTCTGGGAAGTACTTCATCATTTCAAC
GCTCACGAATTCAAAACATAAACAAAGGCTTCCGAGTGCCCCGGCCAGGGGCGCGGGGCGCACGGCGGGCCCGGGGCAGGTAAGCGCAGG
TGCGCGCCCGCCCCCACCCCCGGCTCCCTCCCCATCCGCTCCCCGCTCCCCTTCCCCTTTCCCTTCCCCGCCCGCTCCCAGCCGCCGCCG
CCGCCCCGCGCACGGCCTGGAGCGGAGGCTGCGCAGGGCGCGGGGCGGCGCGGGCCGGGCGCGGGCCGGGCGGACGGCCGCGTCTTTCTT
CTCCTGGCGGTGATGTCATTGGGCGACGGCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGC
GCCTGACAGCGGGCCGGGGCGCACGGAGAAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGAT
GGGCGAGGCGGCGGCGGCGGCGGCGGGGGCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGG
CCGCAGCGATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGG
AGGGCTTTCTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACC
CCGAGCCCCGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGAGATCCTGAA
GGAGCTAGACGAGTGCTACGAGCGCTTCAGTCGCGAGACAGACGGGGCGCAGAAGCGGCGGATGCTGCACTGTGTGCAGCGCGCGCTGAT
CCGCAGCCAGGAGCTGGGCGACGAGAAGATCCAGATCGTGAGCCAGATGGTGGAGCTGGTGGAGAACCGCACGCGGCAGGTGGACAGCCA
CGTGGAGCTGTTCGAGGCGCAGCAGGAGCTGGGCGACACAGCGGGCAACAGCGGCAAGGCTGGCGCGGACAGGCCCAAAGGCGAGGCGGC
AGCGCAGGCTGACAAGCCCAACAGCAAGCGCTCACGGCGGCAGCGCAACAACGAGAACCGTGAGAACGCGTCCAGCAACCACGACCACGA
CGACGGCGCCTCGGGCACACCCAAGGAGAAGAAGGCCAAGACCTCCAAGAAGAAGAAGCGCTCCAAGGCCAAGGCGGAGCGAGAGGCGTC
CCCTGCCGACCTCCCCATCGACCCCAACGAACCCACGTACTGTCTGTGCAACCAGGTCTCCTATGGGGAGATGATCGGCTGCGACAACGA
CGAGTGCCCCATCGAGTGGTTCCACTTCTCGTGCGTGGGGCTCAATCATAAACCCAAGGGCAAGTGGTACTGTCCCAAGTGCCGGGGGGA
GAACGAGAAGACCATGGACAAAGCCCTGGAGAAATCCAAAAAAGAGAGGGCTTACAACAGGTAGTTTGTGGACAGGCGCCTGGTGTGAGG
AGGACAAAATAAACCGTGTATTTATTACATTGCTGCCTTTGTTGAGGTGCAAGGAGTGTAAAATGTATATTTTTAAAGAATGTTAGTAAA
GGAACCATTCCTTTCATAGGGATGGCAGTGATTCTGTTTGCCTTTTGTTTTCATTGGTACACGTGTAACAAGAAAGTGGTCTGTGGATCA
GCATTTTAGAAACTACAAATATAGGTTTGATTCAACA

>6347_6347_1_ARHGEF7-ING1_ARHGEF7_chr13_111806338_ENST00000317133_ING1_chr13_111371576_ENST00000338450_length(amino acids)=277AA_BP=43
MQAAGAPAPRDHRESLPRAPERERVPEQHPRVPARLRGFPAAGEILKELDECYERFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIV
SQMVELVENRTRQVDSHVELFEAQQELGDTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDHDDGASGTPKEKKAK
TSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSK
KERAYNR

--------------------------------------------------------------
>6347_6347_2_ARHGEF7-ING1_ARHGEF7_chr13_111806338_ENST00000370623_ING1_chr13_111371576_ENST00000338450_length(transcript)=1199nt_BP=252nt
ATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTT
CTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACCCCGAGCCC
CGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGAGATCCTGAAGGAGCTAG
ACGAGTGCTACGAGCGCTTCAGTCGCGAGACAGACGGGGCGCAGAAGCGGCGGATGCTGCACTGTGTGCAGCGCGCGCTGATCCGCAGCC
AGGAGCTGGGCGACGAGAAGATCCAGATCGTGAGCCAGATGGTGGAGCTGGTGGAGAACCGCACGCGGCAGGTGGACAGCCACGTGGAGC
TGTTCGAGGCGCAGCAGGAGCTGGGCGACACAGCGGGCAACAGCGGCAAGGCTGGCGCGGACAGGCCCAAAGGCGAGGCGGCAGCGCAGG
CTGACAAGCCCAACAGCAAGCGCTCACGGCGGCAGCGCAACAACGAGAACCGTGAGAACGCGTCCAGCAACCACGACCACGACGACGGCG
CCTCGGGCACACCCAAGGAGAAGAAGGCCAAGACCTCCAAGAAGAAGAAGCGCTCCAAGGCCAAGGCGGAGCGAGAGGCGTCCCCTGCCG
ACCTCCCCATCGACCCCAACGAACCCACGTACTGTCTGTGCAACCAGGTCTCCTATGGGGAGATGATCGGCTGCGACAACGACGAGTGCC
CCATCGAGTGGTTCCACTTCTCGTGCGTGGGGCTCAATCATAAACCCAAGGGCAAGTGGTACTGTCCCAAGTGCCGGGGGGAGAACGAGA
AGACCATGGACAAAGCCCTGGAGAAATCCAAAAAAGAGAGGGCTTACAACAGGTAGTTTGTGGACAGGCGCCTGGTGTGAGGAGGACAAA
ATAAACCGTGTATTTATTACATTGCTGCCTTTGTTGAGGTGCAAGGAGTGTAAAATGTATATTTTTAAAGAATGTTAGTAAAGGAACCAT
TCCTTTCATAGGGATGGCAGTGATTCTGTTTGCCTTTTGTTTTCATTGGTACACGTGTAACAAGAAAGTGGTCTGTGGATCAGCATTTTA
GAAACTACAAATATAGGTTTGATTCAACA

>6347_6347_2_ARHGEF7-ING1_ARHGEF7_chr13_111806338_ENST00000370623_ING1_chr13_111371576_ENST00000338450_length(amino acids)=277AA_BP=43
MQAAGAPAPRDHRESLPRAPERERVPEQHPRVPARLRGFPAAGEILKELDECYERFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIV
SQMVELVENRTRQVDSHVELFEAQQELGDTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDHDDGASGTPKEKKAK
TSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSK
KERAYNR

--------------------------------------------------------------
>6347_6347_3_ARHGEF7-ING1_ARHGEF7_chr13_111806338_ENST00000375741_ING1_chr13_111371576_ENST00000338450_length(transcript)=1449nt_BP=502nt
GCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGCGCCTGACAGCGGGCCGGGGCGCACGGAG
AAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGATGGGCGAGGCGGCGGCGGCGGCGGCGGGG
GCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGGCCGCAGCGATGAATTCCGCCGAGCAAAC
CGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTTCTGCAGGCGTCGCTGAAGGA
TGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACCCCGAGCCCCGGAGCGAGAGCGAGTGCCT
GAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGAGATCCTGAAGGAGCTAGACGAGTGCTACGAGCGCTTC
AGTCGCGAGACAGACGGGGCGCAGAAGCGGCGGATGCTGCACTGTGTGCAGCGCGCGCTGATCCGCAGCCAGGAGCTGGGCGACGAGAAG
ATCCAGATCGTGAGCCAGATGGTGGAGCTGGTGGAGAACCGCACGCGGCAGGTGGACAGCCACGTGGAGCTGTTCGAGGCGCAGCAGGAG
CTGGGCGACACAGCGGGCAACAGCGGCAAGGCTGGCGCGGACAGGCCCAAAGGCGAGGCGGCAGCGCAGGCTGACAAGCCCAACAGCAAG
CGCTCACGGCGGCAGCGCAACAACGAGAACCGTGAGAACGCGTCCAGCAACCACGACCACGACGACGGCGCCTCGGGCACACCCAAGGAG
AAGAAGGCCAAGACCTCCAAGAAGAAGAAGCGCTCCAAGGCCAAGGCGGAGCGAGAGGCGTCCCCTGCCGACCTCCCCATCGACCCCAAC
GAACCCACGTACTGTCTGTGCAACCAGGTCTCCTATGGGGAGATGATCGGCTGCGACAACGACGAGTGCCCCATCGAGTGGTTCCACTTC
TCGTGCGTGGGGCTCAATCATAAACCCAAGGGCAAGTGGTACTGTCCCAAGTGCCGGGGGGAGAACGAGAAGACCATGGACAAAGCCCTG
GAGAAATCCAAAAAAGAGAGGGCTTACAACAGGTAGTTTGTGGACAGGCGCCTGGTGTGAGGAGGACAAAATAAACCGTGTATTTATTAC
ATTGCTGCCTTTGTTGAGGTGCAAGGAGTGTAAAATGTATATTTTTAAAGAATGTTAGTAAAGGAACCATTCCTTTCATAGGGATGGCAG
TGATTCTGTTTGCCTTTTGTTTTCATTGGTACACGTGTAACAAGAAAGTGGTCTGTGGATCAGCATTTTAGAAACTACAAATATAGGTTT
GATTCAACA

>6347_6347_3_ARHGEF7-ING1_ARHGEF7_chr13_111806338_ENST00000375741_ING1_chr13_111371576_ENST00000338450_length(amino acids)=277AA_BP=43
MQAAGAPAPRDHRESLPRAPERERVPEQHPRVPARLRGFPAAGEILKELDECYERFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIV
SQMVELVENRTRQVDSHVELFEAQQELGDTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDHDDGASGTPKEKKAK
TSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSK
KERAYNR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARHGEF7-ING1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARHGEF7-ING1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARHGEF7-ING1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0011616Contact Dermatitis1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0162351Contact hypersensitivity1CTD_human
TgeneC0235874Disease Exacerbation1CTD_human
TgeneC0280302Squamous cell carcinoma of lip1ORPHANET
TgeneC0280313Squamous cell carcinoma of oropharynx1ORPHANET
TgeneC0280321Squamous cell carcinoma of the hypopharynx1ORPHANET
TgeneC0280324Laryngeal Squamous Cell Carcinoma1ORPHANET
TgeneC0585362Squamous cell carcinoma of mouth1ORPHANET
TgeneC1168401Squamous cell carcinoma of the head and neck1CGI;CTD_human;UNIPROT
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human