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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CCNC-GATA3 (FusionGDB2 ID:HG892TG2625) |
Fusion Gene Summary for CCNC-GATA3 |
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Fusion gene information | Fusion gene name: CCNC-GATA3 | Fusion gene ID: hg892tg2625 | Hgene | Tgene | Gene symbol | CCNC | GATA3 | Gene ID | 892 | 2625 |
Gene name | cyclin C | GATA binding protein 3 | |
Synonyms | CycC|SRB11|hSRB11 | HDR|HDRS | |
Cytomap | ('CCNC')('GATA3') 6q16.2 | 10p14 | |
Type of gene | protein-coding | protein-coding | |
Description | cyclin-CSRB11 homolog | trans-acting T-cell-specific transcription factor GATA-3GATA-binding factor 3 | |
Modification date | 20200313 | 20200322 | |
UniProtAcc | P24863 | P23771 | |
Ensembl transtripts involved in fusion gene | ENST00000369220, ENST00000482541, ENST00000518714, ENST00000520371, ENST00000520429, ENST00000521017, ENST00000523799, ENST00000523985, | ||
Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 3 X 3 X 2=18 |
# samples | 5 | 3 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CCNC [Title/Abstract] AND GATA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CCNC(99997162)-GATA3(8116847), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GATA3 | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation | 19483726 |
Tgene | GATA3 | GO:0045893 | positive regulation of transcription, DNA-templated | 19723756|19805038 |
Tgene | GATA3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19232384|20189993|20484083 |
Tgene | GATA3 | GO:0060231 | mesenchymal to epithelial transition | 20189993 |
Tgene | GATA3 | GO:0072676 | lymphocyte migration | 19805038 |
Tgene | GATA3 | GO:2000664 | positive regulation of interleukin-5 secretion | 20554961 |
Tgene | GATA3 | GO:2000667 | positive regulation of interleukin-13 secretion | 20554961 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for CCNC-GATA3 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CCNC-GATA3 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CCNC-GATA3 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:99997162/:8116847) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CCNC | GATA3 |
FUNCTION: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. {ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:8700522}. | FUNCTION: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. {ECO:0000269|PubMed:23824597}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CCNC-GATA3 |
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Fusion Gene PPI Analysis for CCNC-GATA3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CCNC-GATA3 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CCNC-GATA3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C1840333 | Barakat syndrome | 16 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0006413 | Burkitt Lymphoma | 3 | ORPHANET | |
Tgene | C1292769 | Precursor B-cell lymphoblastic leukemia | 3 | ORPHANET | |
Tgene | C0003873 | Rheumatoid Arthritis | 1 | CTD_human | |
Tgene | C0007097 | Carcinoma | 1 | CTD_human | |
Tgene | C0014457 | Eosinophilia | 1 | CTD_human | |
Tgene | C0014458 | Eosinophilia, Tropical | 1 | CTD_human | |
Tgene | C0019829 | Hodgkin Disease | 1 | CTD_human | |
Tgene | C0021368 | Inflammation | 1 | CTD_human | |
Tgene | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human | |
Tgene | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human | |
Tgene | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human | |
Tgene | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human | |
Tgene | C0025568 | Metaplasia | 1 | CTD_human | |
Tgene | C0027819 | Neuroblastoma | 1 | CTD_human | |
Tgene | C0152266 | Mixed Cellularity Hodgkin Lymphoma | 1 | CTD_human | |
Tgene | C0152267 | Hodgkin lymphoma, lymphocyte depletion | 1 | CTD_human | |
Tgene | C0205696 | Anaplastic carcinoma | 1 | CTD_human | |
Tgene | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human | |
Tgene | C0205698 | Undifferentiated carcinoma | 1 | CTD_human | |
Tgene | C0205699 | Carcinomatosis | 1 | CTD_human | |
Tgene | C0220597 | Adult Hodgkin Lymphoma | 1 | CTD_human | |
Tgene | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human | |
Tgene | C1266194 | Lymphocyte Rich Classical Hodgkin Lymphoma | 1 | CTD_human | |
Tgene | C1334968 | Nodular Lymphocyte Predominant Hodgkin Lymphoma | 1 | CTD_human | |
Tgene | C2930967 | Gastro-enteropancreatic neuroendocrine tumor | 1 | CTD_human |